Publications by authors named "Janani Sankar"

33 Publications

Seroprevalence to SARS-CoV-2 Among Healthcare Workers in an Exclusive Pediatric Hospital.

Indian Pediatr 2021 03;58(3):279-280

Department of Pediatrics, Kanchi Kamakoti CHILDS Trust Hospital, Chennai, Tamil Nadu, India.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8005282PMC
March 2021

Prehospital Management of Children with Dengue Fever Admitted in a Tertiary-Care Center.

Indian Pediatr 2021 Feb;58(2):192

Kanchi Kamakoti Childs Trust Hospital, Chennai, India.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7926065PMC
February 2021

Use of Proper Personal Protective Measures among Parents of Children Attending Outpatient Department - An Observational Study.

Indian J Pediatr 2021 Jan 20. Epub 2021 Jan 20.

Department of Pediatrics, Kanchi Kamakoti CHILDS Trust Hospital, 12a Nageshwara Road, Nungambakkam, Chennai, Tamil Nadu, 34, India.

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http://dx.doi.org/10.1007/s12098-020-03624-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7815969PMC
January 2021

Acalypha indica-Induced Hemolysis and Methemoglobinemia in a Child With G6PD Deficiency.

Indian Pediatr 2021 Jan;58(1):92-93

Department of Pediatrics, Kanchi Kamakoti CHILDS Trust Hospital and CHILDS Trust Medical Research Foundation, Nungambakkam, Chennai, India.

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January 2021

Moyamoya Disease 6 with Achalasia Due to GUCY1A3 Mutation in a Child.

Neurol India 2020 Sep-Oct;68(5):1253-1254

Department of Pediatrics, CHILDS Trust Medical Research Foundation, Kanchi Kamakoti CHILDS Trust Hospital, Chennai, Tamil Nadu, India.

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http://dx.doi.org/10.4103/0028-3886.299171DOI Listing
October 2020

Updated Pediatric Tuberculosis Guidelines.

Indian Pediatr 2019 08;56(8):692

Department of Pediatric Medicine and Infectious Diseases, Kanchi Kamakoti CHILDS Trust Hospital, Chennai, Tamil Nadu, India.

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August 2019

Empyema Due to Thoracic Migrating Appendicolith.

Indian Pediatr 2018 07;55(7):603-604

Department of Paediatrics, CHILDS Trust Medical Research Foundation, Kanchi Kamakoti CHILDS Trust Hospital, Chennai, India.

Background: Retained appendicolith following appendicectomy, and can cause recurrent abscess in the abdomen and retroperitoneum.

Case Characteristics: 11-yr-old boy who presented with subpulmonic abscess and pneumonia following appendicectomy for perforated appendicitis.

Observation: Thoracotomy revealed a thick walled subpulmonic abscess surrounding an appendicolith along with a rent in the posterolateral aspect of the diaphragm.

Message: In children presenting with pus collections and a history of recent appendicectomy, the possibility of a migrating appendicolith should be considered.
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July 2018

Autoimmune Encephalitis Following Herpes Simplex Virus Encephalitis in an Infant.

Indian Pediatr 2018 03;55(3):260

Department of Pediatrics, CHILDS Trust Medical Research Foundation, Kanchi Kamakoti CHILDS Trust Hospital, Chennai, India.

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March 2018

Demographic profile of healthy children with nasopharyngeal colonisation of : A research paper.

Indian J Med Microbiol 2017 Oct-Dec;35(4):607-609

Department of Microbiology and Laboratory Services, Sundaram Medical Foundation, Chennai, Tamil Nadu, India.

Background: Pneumonia is a preventable cause of mortality in children. Streptococcus pneumoniae colonising the nasopharynx of healthy children can cause invasive diseases and the serotype distribution of colonisation isolates should be an indicator of invasive disease, antibiotic resistance profiles, and potential vaccine coverage. Identifying factors influencing nasopharyngeal colonisation, the serotypes and antimicrobial resistance pattern can improve rational preventive strategies.

Objectives: Identify risk factors associated with nasopharyngeal colonisation of S.pneumoniae in healthy children between 6 months to 5 years of age. Determine the serotype and antibiotic sensitivity of S. pneumoniae isolated from nasopharynx of healthy children.

Methods: This prospective observational included 500 healthy children, 6months to 5 years of age. Demographic features of the study population, the serotypes and antimicrobial sensitivity pattern of S.Pneumoniae isolated from cultures of nasopharyngeal swabs were subjected to statistical analysis.

Results: S. pneumoniae was isolated in 9% of 450 children. Increased nasopharyngeal carriage rate was associated with overcrowding 48.8% and poor ventilation 35.5%. 6B (n=16) was the most common serotype isolated. 69% were serogroups known to cause invasive disease All S. pneumoniae isolates were susceptible to vancomycin and linezolid. Antimicrobial susceptibility of PCV 7 serotypes were greater than non PCV 7 serotypes for almost all antimicrobials tested. Penicillin resistance was 11 % and MDR 51.
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http://dx.doi.org/10.4103/ijmm.IJMM_15_347DOI Listing
August 2018

Non-Typhoidal Salmonella Bacteremia.

Indian J Pediatr 2018 09 21;85(9):800-802. Epub 2017 Dec 21.

Department of Microbiology, Kanchi Kamakoti CHILDS Trust Hospital & The CHILDS Trust Medical Research Foundation, 12-A, Nageswara Road, Nungambakkam, Chennai, Tamil Nadu, 600034, India.

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http://dx.doi.org/10.1007/s12098-017-2551-6DOI Listing
September 2018

Mixed Malarial Infection with Pancytopenia in a Child with Acute Lymphoblastic Leukemia: An Unusual Presentation.

Indian J Med Paediatr Oncol 2017 Jan-Mar;38(1):92

Department of Pediatrics, CHILDS Trust Medical Research Foundation, Kanchi Kamakoti Childs Trust Hospital, Chennai, Tamil Nadu, India.

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http://dx.doi.org/10.4103/0971-5851.203507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398119PMC
May 2017

Infantile Cortical Hyperostosis of Scapula Presenting as Pseudoparalysis in an Infant.

Indian Pediatr 2017 02;54(2):157-158

Department of Pediatrics, CHILDS Trust Medical Research Foundation, Kanchi Kamakoti CHILDS Trust Hospital, Chennai, India

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http://dx.doi.org/10.1007/s13312-017-1023-4DOI Listing
February 2017

Recurrent Intussusception in an Infant.

Indian Pediatr 2016 Jul;53(7):655

Department of Pediatrics, CHILDS Trust Medical Research Foundation, Kanchi Kamakoti CHILDS Trust Hospital, Chennai, India.

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http://dx.doi.org/10.1007/s13312-016-0906-0DOI Listing
July 2016

Intracerebral Hematoma in an Infant with Herpes Simplex Encephalitis.

Indian Pediatr 2015 Nov;52(11):991

Department of Pediatrics, CHILDS Trust Medical Research Foundation, Kanchi Kamakoti CHILDS Trust Hospital, Chennai, India.

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http://dx.doi.org/10.1007/s13312-015-0762-3DOI Listing
November 2015

Is Antibiotic Exposure Associated With Newly Diagnosed Juvenile Idiopathic Arthritis?

Indian Pediatr 2015 Oct;52(10):883-8

Department of Pediatrics, PGIMER, Chandigarh, India.

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http://dx.doi.org/10.1007/s13312-015-0737-4DOI Listing
October 2015

Aicardi-Goutieres syndrome: A genetic disorder which mimics congenital intrauterine infection.

Neurol India 2013 Jan-Feb;61(1):77-8

Department of Pediatrics, CHILDS Trust Medical Research Foundation, Kanchi Kamakoti CHILDS Trust Hospital, Chennai, India.

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http://dx.doi.org/10.4103/0028-3886.108018DOI Listing
April 2016

Recurrent pneumococcal meningitis in a child with congenital common cavity malformation of the inner ear.

Clin Pediatr (Phila) 2014 Apr 4;53(4):397-8. Epub 2013 Mar 4.

1Department of Pediatrics & Otorhinolaryngology, Kanchi Kamakoti CHILDS Trust Hospital, Chennai, India.

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http://dx.doi.org/10.1177/0009922813479019DOI Listing
April 2014

Testosterone levels and androgen receptor gene polymorphism predict specific symptoms of depression in young men.

Gend Med 2012 Aug 23;9(4):232-43. Epub 2012 Jun 23.

Department of Psychology, University of Western Ontario, 1151 Richmond St, London, ON, Canada.

Background: Testosterone (T) has been hypothesized to modulate the expression of depressive symptoms in men; however, support for this proposition is mixed.

Objective: To investigate bioavailable T, measured from saliva, and androgen receptor gene (AR) polymorphism (the number of glutamine [CAG] repeats in exon 1 of AR) and their relation to discrete symptoms of depression in 150 men aged 17 to 27 years who varied in mood status from depressed to nondepressed.

Methods: Participants completed the Center for Epidemiologic Studies Depression Scale and the Patient Health Questionnaire-9. Principal components analysis of the scales identified 5 factors: Negative Affect, Social/Evaluative, Cognitive, Sleep, and Appetite.

Results: Across the sample as a whole, higher ratings on sleep symptoms of depression were predicted by lower T concentrations and shorter CAG lengths. The association between T, CAG length, and sleep symptoms was confirmed among the subgroup of men who reported moderate to severe depression. In this subgroup, CAG repeats and T concentrations also emerged as significant predictors of negative affect scores, with the number of CAG repeats making the primary contribution.

Conclusions: These findings suggest that androgens may influence specific symptoms of depression in men.
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http://dx.doi.org/10.1016/j.genm.2012.05.001DOI Listing
August 2012

Hand preference in humans is associated with testosterone levels and androgen receptor gene polymorphism.

Neuropsychologia 2012 Jul 9;50(8):2018-25. Epub 2012 May 9.

Department of Psychology, University of Western Ontario, London, ON, Canada N6A 5C2.

Exposure of the central nervous system to androgens during the early developmental period has been proposed to play a role in the establishment of hand preference in males. Existing data, however, are inconclusive. In the present investigation, handedness was assessed in a large sample of left-, mixed-, and right-handed men (N=180) using a standardized handedness inventory. Saliva sampling was used to assay levels of bioavailable testosterone and DNA genotyping was carried out to quantify AR-CAG repeat length, a genetic marker of the capacity of the androgen receptor to respond to testosterone. Strongly left-handed males were found to have lower levels of bioavailable testosterone than right-handed males, while males with mixed handedness exhibited a weaker androgen receptor, but no significant difference from right-handers in circulating testosterone levels. These findings support the view that testosterone could play a role in the development of hand preference in males. Furthermore, because the AR gene lies on the X chromosome, it provides a potential theoretical bridge to genetic theories of handedness that postulate the existence of an X-linked locus important in the establishment of hand preference.
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http://dx.doi.org/10.1016/j.neuropsychologia.2012.04.027DOI Listing
July 2012

Inflammatory demyelinating disorders of childhood: experience with six children.

Neurol India 2010 May-Jun;58(3):452-6

Department of Pediatrics, Kanchi Kamakoti CHILDS Trust Hospital, Chennai, India.

Demyelinating disorders of the central nervous system (CNS) in children pose diagnostic and prognostic difficulties in clinical practice. In this report, we describe our experience with inflammatory demyelinating disorders of CNS in six children, classified as per the proposed criteria by the Pediatric Multiple Sclersois Study Group. We emphasize the importance of appropriate diagnosis and follow-up to distinguish transient inflammatory demyelinating diseases from chronic inflammatory demyelinating diseases.
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http://dx.doi.org/10.4103/0028-3886.65751DOI Listing
October 2010

Primary intestinal lymphangiectasia.

Indian Pediatr 2009 Oct;46(10):903-6

Departments of Pediatrics and Gastroenterology, Kanchi Kamakoti CHILDS Trust Hospital, Nungambakkam, Chennai, Tamil Nadu, India.

Primary intestinal lymphangiectasia (PIL) is a rare disease of intestinal lymphatics presenting with hypoproteinemia, bilateral lower limb edema, ascites, and protein losing enteropathy. We report a series of 4 children from Chennai, India presenting with anasarca, recurrent diarrhea, hypoproteinemia and confirmatory features of PIL on endoscopy and histopathology.
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October 2009

Hypertension due to angiodysplasia.

Indian J Pediatr 2009 Jul 27;76(7):751-2. Epub 2009 May 27.

Department of Pediatrics, Kanchi Kamakoti CHILDS Trust Hospital, Chennai, India.

Renovascular hypertension is non essential hypertension, wherein anatomically evident arterial occlusive disease and increased blood pressures are related as cause and effect. The hypertension is due to renal ischemia. Angiodysplasia is an uncommon angiopathy associated with heterogeneous histological changes that may affect the carotid circulation and the visceral and peripheral arteries.
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http://dx.doi.org/10.1007/s12098-009-0149-3DOI Listing
July 2009

Gorhams disease: vanishing bone syndrome.

Indian Pediatr 2009 Mar;46(3):255-6

Department of Pediatrics, Kanchi Kamakoti CHILDS Trust Hospital, Nungambakkam, Chennai, India.

Gorhams disease, also known as massive osteolysis or vanishing bone disease is an extremely rare bone disease. It is characterized by angiomatosis with adjacent bone resorption. We report an 8-years old boy with the disease who was managed successfully with alpha 2b interferon therapy.
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March 2009

An unusual cause of acute torticollis.

Clin Pediatr (Phila) 2009 Sep 17;48(7):784-5. Epub 2009 Feb 17.

Department of Pediatrics, Childs Trust Hospital, Chennai, Tamil Nadu, India.

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http://dx.doi.org/10.1177/0009922808330785DOI Listing
September 2009

Facially disfigured children--dedicated approach and rehabilitation.

Dev Neurorehabil 2007 Apr-Jun;10(2):99-104

Department of Plastic Surgery and Burns Unit, K. K. Childs Trust Hospital, Chennai, India.

Facial disfigurement following congenital anomalies or acquired defects due to accidents or scars results in mental trauma and other related consequences. A multidisciplinary team approach with special importance to rehabilitation is required in handling such patients.
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http://dx.doi.org/10.1080/13638490701217362DOI Listing
September 2007

Atypical presentation of atypical organism.

Indian Pediatr 2007 Feb;44(2):151

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February 2007

Role of biological membranes in the management of Stevens Johnson syndrome--Indian experience.

Burns 2007 Feb 13;33(1):109-11. Epub 2006 Nov 13.

Department of Pediatrics/Plastic Surgery/Burns, Kanchi Kamakoti Childs Trust Hospital, 12A, Nageswara Road, Nungambakkam, Chennai 600034, India.

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http://dx.doi.org/10.1016/j.burns.2006.04.029DOI Listing
February 2007