Publications

Development of potent and proteolytically stable human neuromedin U receptor agonists.
Eur J Med Chem 2017 Dec 14;144:887-897. Epub 2017 Dec 14.
Research Group of Organic Chemistry, Departments of Chemistry and Bioengineering Sciences, Vrije Universiteit Brussel, Pleinlaan 2, 1050, Brussels, Belgium. Electronic address:

Selective changes in locomotor activity in mice due to low-intensity microwaves amplitude modulated in the EEG spectral domain.
Neuroscience 2017 Sep 5;359:40-48. Epub 2017 Jul 5.
Department of Electronics and Informatics (ETRO), Laboratory for micro- and photon electronics (LAMI), Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium. Electronic address:

Slc7a11 (xCT) protein expression is not altered in the depressed brain and system xc- deficiency does not affect depression-associated behaviour in the corticosterone mouse model.
World J Biol Psychiatry 2017 Sep 27:1-12. Epub 2017 Sep 27.
a Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information , Center for Neurosciences (C4N), Vrije Universiteit Brussel , Brussels , Belgium.

Zonisamide attenuates lactacystin-induced parkinsonism in mice without affecting system xc.
Exp Neurol 2017 Apr 24;290:15-28. Epub 2016 Dec 24.
Department of Pharmaceutical Biotechnology and Molecular Biology, Center for Neurosciences, Vrije Universiteit Brussel, Brussels, Belgium. Electronic address:

LC-method development for the quantification of neuromedin-like peptides. Emphasis on column choice and mobile phase composition.
J Pharm Biomed Anal 2017 Apr 11;137:104-112. Epub 2017 Jan 11.
Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information (FASC), Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, 1090 Brussels, Belgium. Electronic address:

Accelerated high-frequency repetitive transcranial magnetic stimulation enhances motor activity in rats.
Neuroscience 2017 Apr 9;347:103-110. Epub 2017 Feb 9.
Molecular Imaging Center Antwerp (MICA), Universiteitsplein 1, 2610 Wilrijk, University of Antwerp, Antwerp, Belgium. Electronic address:

In-vitro and in-vivo evaluation of the modulatory effects of the multitarget compound ASS234 on the monoaminergic system.
J Pharm Pharmacol 2017 Mar 30;69(3):314-324. Epub 2017 Jan 30.
Departament de Bioquímica i Biologia Molecular, Facultat de Medicina, Institute of Neurosciences, Universitat Autònoma de Barcelona, Bellaterra (Cerdanyola del Vallès), Spain.

Caloric Restriction Protects against Lactacystin-Induced Degeneration of Dopamine Neurons Independent of the Ghrelin Receptor.
Int J Mol Sci 2017 Mar 4;18(3). Epub 2017 Mar 4.
Research Group Experimental Pharmacology (EFAR/FASC), Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, 1090 Brussel, Belgium.

An improved microbore UHPLC method with electrochemical detection for the simultaneous determination of low monoamine levels in in vivo brain microdialysis samples.
J Pharm Biomed Anal 2016 Aug 13;127:136-46. Epub 2016 Jan 13.
Department of Pharmaceutical Chemistry and Drug Analysis, Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, 1090 Brussels, Belgium. Electronic address:

Disruption of the HPA-axis through corticosterone-release pellets induces robust depressive-like behavior and reduced BDNF levels in mice.
Neurosci Lett 2016 Jul 18;626:119-25. Epub 2016 May 18.
Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information (FASC), Center for Neurosciences (C4N), Vrije Universiteit Brussel, Brussels, Belgium. Electronic address:

Comparative analysis of antibodies to xCT (Slc7a11): Forewarned is forearmed.
J Comp Neurol 2016 Apr 23;524(5):1015-32. Epub 2015 Oct 23.
Department of Pharmaceutical Biotechnology and Molecular Biology, Center for Neurosciences, Vrije Universiteit Brussel, Brussels, 1090, Belgium.

In-depth behavioral characterization of the corticosterone mouse model and the critical involvement of housing conditions.
Physiol Behav 2016 Mar 18;156:199-207. Epub 2015 Dec 18.
Department of Pharmaceutical Chemistry and Drug Analysis, Center for Neurosciences, Vrije Universiteit Brussel, Brussels, Belgium. Electronic address:

Higher-Density Culture in Human Embryonic Stem Cells Results in DNA Damage and Genome Instability.
Stem Cell Reports 2016 Mar 25;6(3):330-41. Epub 2016 Feb 25.
Research Group Reproduction and Genetics, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, 1090 Brussels, Belgium. Electronic address:

Alterations in the motor cortical and striatal glutamatergic system and D-serine levels in the bilateral 6-hydroxydopamine rat model for Parkinson's disease.
Neurochem Int 2015 Sep 11;88:88-96. Epub 2015 Jul 11.
Department of Pharmaceutical Biotechnology and Molecular Biology, Center for Neurosciences, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090 Brussels, Belgium. Electronic address:

Validation of the 6 Hz refractory seizure mouse model for intracerebroventricularly administered compounds.
Epilepsy Res 2015 Sep 6;115:67-72. Epub 2015 Jun 6.
Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information, Center for Neurosciences, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium. Electronic address:

Neuropeptide FF receptors as novel targets for limbic seizure attenuation.
Neuropharmacology 2015 Aug 9;95:415-23. Epub 2015 May 9.
Center for Neurosciences, Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium. Electronic address:

Reassessment of the antioxidative mixture for the challenging electrochemical determination of dopamine, noradrenaline and serotonin in microdialysis samples.
J Chromatogr B Analyt Technol Biomed Life Sci 2015 Aug 2;998-999:63-71. Epub 2015 Jul 2.
Department of Pharmaceutical Chemistry and Drug Analysis, Center for Neurosciences, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Jette, Belgium. Electronic address:


Absence of system xc- in mice decreases anxiety and depressive-like behavior without affecting sensorimotor function or spatial vision.
Prog Neuropsychopharmacol Biol Psychiatry 2015 Jun 23;59:49-58. Epub 2015 Jan 23.
Department of Pharmaceutical Chemistry and Drug Analysis, Center for Neurosciences, Vrije Universiteit Brussel, Brussels, Belgium. Electronic address:

Effects of AT1 receptor antagonism on kainate-induced seizures and concomitant changes in hippocampal extracellular noradrenaline, serotonin, and dopamine levels in Wistar-Kyoto and spontaneously hypertensive rats.
Epilepsy Behav 2015 May 23;46:66-71. Epub 2015 Apr 23.
Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information, Center for Neurosciences (C4N), Vrije Universiteit Brussel, Brussels, Belgium.

Neuropeptide FF and prolactin-releasing peptide decrease cortical excitability through activation of NPFF receptors.
Epilepsia 2015 Mar 12;56(3):489-98. Epub 2015 Feb 12.
Laboratory for Clinical and Experimental Neurophysiology, Neurobiology and Neuropsychology, Department of Neurology, Ghent University Hospital, Ghent University, Ghent, Belgium.


NMDA receptor antagonism potentiates the L-DOPA-induced extracellular dopamine release in the subthalamic nucleus of hemi-parkinson rats.
Neuropharmacology 2014 Oct 24;85:198-205. Epub 2014 May 24.
Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information, Center for Neuroscience, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090 Brussels, Belgium. Electronic address:


Cortistatin-14 mediates its anticonvulsant effects via sst2 and sst3 but not ghrelin receptors.
CNS Neurosci Ther 2014 Jul 31;20(7):662-70. Epub 2014 Mar 31.
Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information, Research Group Experimental Pharmacology, Center for Neurosciences (C4N), Vrije Universiteit Brussel, Brussels, Belgium.

Role(s) of the 5-HT2C receptor in the development of maximal dentate activation in the hippocampus of anesthetized rats.
CNS Neurosci Ther 2014 Jul;20(7):651-61
Dipartimento di Biomedicina Sperimentale e Neuroscienze Cliniche, Università degli Studi di Palermo, Palermo, Italy; Istituto Euro-Mediterraneo di Scienza e Tecnologia (IEMEST), Palermo, Italy.


Inactivation of the constitutively active ghrelin receptor attenuates limbic seizure activity in rodents.
Neurotherapeutics 2012 Jul;9(3):658-72
Center for Neurosciences, Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium.

Rat hippocampal somatostatin sst3 and sst4 receptors mediate anticonvulsive effects in vivo: indications of functional interactions with sst2 receptors.
Neuropharmacology 2011 Dec 16;61(8):1327-33. Epub 2011 Aug 16.
Center for Neuroscience, Department of Pharmaceutical Chemistry and Drug Analysis, CePhar, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium.

Assessment of the convulsant liability of antidepressants using zebrafish and mouse seizure models.
Epilepsy Behav 2011 Nov 1;22(3):450-60. Epub 2011 Oct 1.
Department of Pharmaceutical Chemistry and Drug Analysis, Center for Neuroscience, Vrije Universiteit Brussel, Brussels, Belgium.



Dopaminergic neurons of system x(c)⁻-deficient mice are highly protected against 6-hydroxydopamine-induced toxicity.
FASEB J 2011 Apr 29;25(4):1359-69. Epub 2010 Dec 29.
Department of Pharmaceutical Chemistry and Drug Analysis, Research Group Experimental Pharmacology, Vrije Universiteit Brussel, Brussels, Belgium.


Pharmacological and neurochemical characterization of the involvement of hippocampal adrenoreceptor subtypes in the modulation of acute limbic seizures.
J Neurochem 2010 Dec 19;115(6):1595-607. Epub 2010 Nov 19.
Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information, Research Group Experimental Pharmacology, Vrije Universiteit Brussel, Brussels, Belgium.

Involvement of the AT1 receptor subtype in the effects of angiotensin IV and LVV-haemorphin 7 on hippocampal neurotransmitter levels and spatial working memory.
J Neurochem 2010 Mar 17;112(5):1223-34. Epub 2009 Dec 17.
Research Group Experimental Pharmacology, Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information, Vrije Universiteit Brussel, Brussels, Belgium.

Prediction of antiepileptic drug efficacy: the use of intracerebral microdialysis to monitor biophase concentrations.
Expert Opin Drug Metab Toxicol 2009 Oct;5(10):1267-77
Vrije Universiteit Brussel (VUB), Pharmaceutical Institute, Research Group Experimental Pharmacology, Department of Pharmaceutical Chemistry and Drug Analysis (labo FASC), Laarbeeklaan 103, Building G, 1090 Brussels, Belgium.

Involvement of insulin-regulated aminopeptidase in the effects of the renin-angiotensin fragment angiotensin IV: a review.
Heart Fail Rev 2008 Sep 8;13(3):321-37. Epub 2007 Nov 8.
Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information, Research Group Experimental Pharmacology, Vrije Universiteit Brussel, Brussels, Belgium.

Critical Evaluation of Acetylcholine Determination in Rat Brain Microdialysates using Ion-Pair Liquid Chromatography with Amperometric Detection.
Sensors (Basel) 2008 Aug 28;8(8):5171-5185. Epub 2008 Aug 28.
Experimental Neuropharmacology Research Group, Department of Pharmaceutical Chemistry and Drug Analysis, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussel, Belgium.

Direct enhancement of hippocampal dopamine or serotonin levels as a pharmacodynamic measure of combined antidepressant-anticonvulsant action.
Neuropharmacology 2008 May 1;54(6):1017-28. Epub 2008 Apr 1.
Department of Pharmaceutical Chemistry, Drug Analysis & Drug Information, Research Group on Experimental Pharmacology, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium.

Involvement of insulin-regulated aminopeptidase and/or aminopeptidase N in the angiotensin IV-induced effect on dopamine release in the striatum of the rat.
Brain Res 2007 Feb 13;1131(1):97-105. Epub 2006 Dec 13.
Research Group Experimental Pharmacology, Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information, Vrije Universiteit Brussel Laarbeeklaan 103 B-1090 Brussels, Belgium.

Capillary and nano-liquid chromatography-tandem mass spectrometry for the quantification of small molecules in microdialysis samples: comparison with microbore dimensions.
J Chromatogr A 2006 Oct 30;1131(1-2):166-75. Epub 2006 Aug 30.
Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information, Research Group Experimental Pharmacology, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium.

Use of a structural analogue versus a stable isotope labeled internal standard for the quantification of angiotensin IV in rat brain dialysates using nano-liquid chromatography/tandem mass spectrometry.
Rapid Commun Mass Spectrom 2007 ;21(7):1187-95
Research Group Experimental Pharmacology, Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information, Vrije Universiteit Brussel, Brussels, Belgium.

Region- and age-specific changes in glutamate transport in the AβPP23 mouse model for Alzheimer's disease.
J Alzheimers Dis 2011 ;24(2):287-300
Research Group Experimental Pharmacology, Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information, Centre of Pharmaceutical Research, Vrije Universiteit Brussel, Brussel, Belgium.

An ultrasensitive nano UHPLC-ESI-MS/MS method for the quantification of three neuromedin-like peptides in microdialysates.
Bioanalysis 2015 ;7(5):605-19
Department of Pharmaceutical Chemistry & Drug Analysis, Center for Neurosciences (C4N), Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium.

Nigral proteasome inhibition in mice leads to motor and non-motor deficits and increased expression of Ser129 phosphorylated α-synuclein.
Front Behav Neurosci 2015 31;9:68. Epub 2015 Mar 31.
Department of Pharmaceutical Biotechnology and Molecular Biology, Center for Neurosciences, Vrije Universiteit Brussel Brussels, Belgium.

Monoaminergic and Histaminergic Strategies and Treatments in Brain Diseases.
Front Neurosci 2016 24;10:541. Epub 2016 Nov 24.
Centre National de la Recherche Scientifique (Unité Mixte de Recherche 5293), Institut of Neurodegenerative Diseases Bordeaux Cedex, France.

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