Ilse Smolders

Ilse Smolders

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Ilse Smolders

Publications by authors named "Ilse Smolders"

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100Publications

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Sensitive targeted methods for brain metabolomic studies in microdialysis samples.

J Pharm Biomed Anal 2018 Nov 23;161:192-205. Epub 2018 Aug 23.

Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information (FASC), Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, 1090 Brussels, Belgium. Electronic address:

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November 2018

Genetic deletion of xCT attenuates peripheral and central inflammation and mitigates LPS-induced sickness and depressive-like behavior in mice.

Glia 2018 09 25;66(9):1845-1861. Epub 2018 Apr 25.

Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information, Center for Neurosciences (C4N), Vrije Universiteit Brussel, Brussels, 1090, Belgium.

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September 2018

GABAergic Signaling Mediates Central Cardiovascular Angiotensin II Type 2 Receptor Effects.

Trends Endocrinol Metab 2018 Sep 5;29(9):605-606. Epub 2018 May 5.

Laboratory of Pharmaceutical Chemistry, Drug Analysis and Drug Information (FASC), Research Group Experimental Pharmacology (EFAR), Center for Neurosciences (C4N), Vrije Universiteit Brussel, Belgium; Research Group Clinical Pharmacology and Clinical Pharmacy, Vrije Universiteit Brussel, Belgium; Department of Clinical Pharmacology, Universitair Ziekenhuis Brussel, Belgium.

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September 2018

The Barnes Maze Task Reveals Specific Impairment of Spatial Learning Strategy in the Intrahippocampal Kainic Acid Model for Temporal Lobe Epilepsy.

Neurochem Res 2018 Aug 10. Epub 2018 Aug 10.

Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information, Research Group Experimental Pharmacology, Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, 1090, Brussels, Belgium.

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August 2018

Erratum to "Selective Changes in Locomotor Activity in Mice Due to Low-intensity Microwaves Amplitude Modulated in the EEG Spectral Domain" [Neuroscience 359 (2017) 40-48].

Neuroscience 2018 Jul 13. Epub 2018 Jul 13.

Department of Electronics and Informatics (ETRO), Laboratory for Micro- and Photon Electronics (LAMI), Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium. Electronic address:

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July 2018

Synthesis and Evaluation of Stabilized and Selective Neuromedin U-1 Receptor Agonists.

ACS Med Chem Lett 2018 May 23;9(5):496-501. Epub 2018 Apr 23.

Research Group of Organic Chemistry, Departments of Chemistry and Bioengineering Sciences, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium.

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May 2018

Inhibition of astroglial connexin43 hemichannels with TAT-Gap19 exerts anticonvulsant effects in rodents.

Glia 2018 Apr 23. Epub 2018 Apr 23.

Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information, Research group Experimental Pharmacology (EFAR), Center for Neurosciences (C4N), Vrije Universiteit Brussel, Laarbeeklaan 103, Brussels, 1090, Belgium.

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April 2018

6 Hz corneal kindling in mice triggers neurobehavioral comorbidities accompanied by relevant changes in c-Fos immunoreactivity throughout the brain.

Epilepsia 2018 01 20;59(1):67-78. Epub 2017 Nov 20.

Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information, Center for Neurosciences, Vrije Universiteit Brussel, Brussels, Belgium.

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January 2018

Development of potent and proteolytically stable human neuromedin U receptor agonists.

Eur J Med Chem 2018 Jan 14;144:887-897. Epub 2017 Dec 14.

Research Group of Organic Chemistry, Departments of Chemistry and Bioengineering Sciences, Vrije Universiteit Brussel, Pleinlaan 2, 1050, Brussels, Belgium. Electronic address:

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January 2018

Selective changes in locomotor activity in mice due to low-intensity microwaves amplitude modulated in the EEG spectral domain.

Neuroscience 2017 09 5;359:40-48. Epub 2017 Jul 5.

Department of Electronics and Informatics (ETRO), Laboratory for micro- and photon electronics (LAMI), Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium. Electronic address:

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September 2017

Slc7a11 (xCT) protein expression is not altered in the depressed brain and system xc- deficiency does not affect depression-associated behaviour in the corticosterone mouse model.

World J Biol Psychiatry 2017 Sep 27:1-12. Epub 2017 Sep 27.

a Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information , Center for Neurosciences (C4N), Vrije Universiteit Brussel , Brussels , Belgium.

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September 2017

Running Opposes the Effects of Social Isolation on Synaptic Plasticity and Transmission in a Rat Model of Depression.

PLoS One 2016 20;11(10):e0165071. Epub 2016 Oct 20.

Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.

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June 2017

Hypotensive Response to Angiotensin II Type 2 Receptor Stimulation in the Rostral Ventrolateral Medulla Requires Functional GABA-A Receptors.

Front Neurosci 2017 19;11:346. Epub 2017 Jun 19.

Laboratory of Pharmaceutical Chemistry, Drug Analysis and Drug Information (FASC), Research Group Experimental Pharmacology (EFAR), Center for Neurosciences (C4N), Vrije Universiteit BrusselBrussels, Belgium.

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June 2017

Glutamate released in the preoptic area during sexual behavior controls local estrogen synthesis in male quail.

Psychoneuroendocrinology 2017 May 8;79:49-58. Epub 2017 Feb 8.

GIGA Neurosciences, Research Group in Behavioral Neuroendocrinology, Neuroendocrinology unit, University of Liège, 15 Avenue Hippocrate (B36), 4000 Liège, Belgium.

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May 2017

Zonisamide attenuates lactacystin-induced parkinsonism in mice without affecting system x.

Exp Neurol 2017 04 24;290:15-28. Epub 2016 Dec 24.

Department of Pharmaceutical Biotechnology and Molecular Biology, Center for Neurosciences, Vrije Universiteit Brussel, Brussels, Belgium. Electronic address:

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April 2017

LC-method development for the quantification of neuromedin-like peptides. Emphasis on column choice and mobile phase composition.

J Pharm Biomed Anal 2017 Apr 11;137:104-112. Epub 2017 Jan 11.

Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information (FASC), Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, 1090 Brussels, Belgium. Electronic address:

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April 2017

Accelerated high-frequency repetitive transcranial magnetic stimulation enhances motor activity in rats.

Neuroscience 2017 04 9;347:103-110. Epub 2017 Feb 9.

Molecular Imaging Center Antwerp (MICA), Universiteitsplein 1, 2610 Wilrijk, University of Antwerp, Antwerp, Belgium. Electronic address:

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April 2017

Pharmacological Analysis of the Anti-epileptic Mechanisms of Fenfluramine in Mutant Zebrafish.

Front Pharmacol 2017 6;8:191. Epub 2017 Apr 6.

Department of Development and Regeneration, Section Pediatric Neurology, University Hospital KU LeuvenLeuven, Belgium.

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April 2017

In-vitro and in-vivo evaluation of the modulatory effects of the multitarget compound ASS234 on the monoaminergic system.

J Pharm Pharmacol 2017 Mar 30;69(3):314-324. Epub 2017 Jan 30.

Departament de Bioquímica i Biologia Molecular, Facultat de Medicina, Institute of Neurosciences, Universitat Autònoma de Barcelona, Bellaterra (Cerdanyola del Vallès), Spain.

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March 2017

Caloric Restriction Protects against Lactacystin-Induced Degeneration of Dopamine Neurons Independent of the Ghrelin Receptor.

Int J Mol Sci 2017 Mar 4;18(3). Epub 2017 Mar 4.

Research Group Experimental Pharmacology (EFAR/FASC), Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, 1090 Brussel, Belgium.

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March 2017

Inhibition of Connexin43 Hemichannels Impairs Spatial Short-Term Memory without Affecting Spatial Working Memory.

Front Cell Neurosci 2016 20;10:288. Epub 2016 Dec 20.

Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information, Center for Neurosciences, Vrije Universiteit Brussel Brussels, Belgium.

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December 2016

Monoaminergic Mechanisms in Epilepsy May Offer Innovative Therapeutic Opportunity for Monoaminergic Multi-Target Drugs.

Front Neurosci 2016 10;10:492. Epub 2016 Nov 10.

Laboratory of Neurophysiology, Department of Physiology and Biochemistry, University of Malta Msida, Malta.

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November 2016

Monoaminergic and Histaminergic Strategies and Treatments in Brain Diseases.

Front Neurosci 2016 24;10:541. Epub 2016 Nov 24.

Centre National de la Recherche Scientifique (Unité Mixte de Recherche 5293), Institut of Neurodegenerative Diseases Bordeaux Cedex, France.

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November 2016

Anticonvulsant effect of a ghrelin receptor agonist in 6Hz corneally kindled mice.

Epilepsia 2016 09 5;57(9):e195-9. Epub 2016 Jul 5.

Center for Neurosciences, VUB Free University Brussels, Brussels, Belgium.

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September 2016

Challenges for the in vivo quantification of brain neuropeptides using microdialysis sampling and LC-MS.

Bioanalysis 2016 Sep 24;8(18):1965-85. Epub 2016 Aug 24.

Department of Pharmaceutical Chemistry, Drug Analysis & Drug Information, Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, 1090 Brussels, Belgium.

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September 2016

An improved microbore UHPLC method with electrochemical detection for the simultaneous determination of low monoamine levels in in vivo brain microdialysis samples.

J Pharm Biomed Anal 2016 Aug 13;127:136-46. Epub 2016 Jan 13.

Department of Pharmaceutical Chemistry and Drug Analysis, Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, 1090 Brussels, Belgium. Electronic address:

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August 2016

Blood-brain barrier transport kinetics of the neuromedin peptides NMU, NMN, NMB and NT.

Neuropharmacology 2016 08 1;107:460-470. Epub 2016 Apr 1.

Drug Quality and Registration (DruQuaR) Group, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium. Electronic address:

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August 2016

Disruption of the HPA-axis through corticosterone-release pellets induces robust depressive-like behavior and reduced BDNF levels in mice.

Neurosci Lett 2016 07 18;626:119-25. Epub 2016 May 18.

Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information (FASC), Center for Neurosciences (C4N), Vrije Universiteit Brussel, Brussels, Belgium. Electronic address:

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July 2016

Serotonergic Modulation as Effective Treatment for Dravet Syndrome in a Zebrafish Mutant Model.

ACS Chem Neurosci 2016 05 17;7(5):588-98. Epub 2016 Feb 17.

Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven , 3000 Leuven, Belgium.

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May 2016

Comparative analysis of antibodies to xCT (Slc7a11): Forewarned is forearmed.

J Comp Neurol 2016 Apr 23;524(5):1015-32. Epub 2015 Oct 23.

Department of Pharmaceutical Biotechnology and Molecular Biology, Center for Neurosciences, Vrije Universiteit Brussel, Brussels, 1090, Belgium.

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April 2016

In-depth behavioral characterization of the corticosterone mouse model and the critical involvement of housing conditions.

Physiol Behav 2016 Mar 18;156:199-207. Epub 2015 Dec 18.

Department of Pharmaceutical Chemistry and Drug Analysis, Center for Neurosciences, Vrije Universiteit Brussel, Brussels, Belgium. Electronic address:

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March 2016

Higher-Density Culture in Human Embryonic Stem Cells Results in DNA Damage and Genome Instability.

Stem Cell Reports 2016 Mar 25;6(3):330-41. Epub 2016 Feb 25.

Research Group Reproduction and Genetics, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, 1090 Brussels, Belgium. Electronic address:

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March 2016

An ultrasensitive nano UHPLC-ESI-MS/MS method for the quantification of three neuromedin-like peptides in microdialysates.

Bioanalysis 2015 ;7(5):605-19

Department of Pharmaceutical Chemistry & Drug Analysis, Center for Neurosciences (C4N), Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium.

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December 2015

Alterations in the motor cortical and striatal glutamatergic system and D-serine levels in the bilateral 6-hydroxydopamine rat model for Parkinson's disease.

Neurochem Int 2015 Sep 11;88:88-96. Epub 2015 Jul 11.

Department of Pharmaceutical Biotechnology and Molecular Biology, Center for Neurosciences, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090 Brussels, Belgium. Electronic address:

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September 2015

Validation of the 6 Hz refractory seizure mouse model for intracerebroventricularly administered compounds.

Epilepsy Res 2015 Sep 6;115:67-72. Epub 2015 Jun 6.

Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information, Center for Neurosciences, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium. Electronic address:

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September 2015

Neuropeptide FF receptors as novel targets for limbic seizure attenuation.

Neuropharmacology 2015 Aug 9;95:415-23. Epub 2015 May 9.

Center for Neurosciences, Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium. Electronic address:

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August 2015

Reassessment of the antioxidative mixture for the challenging electrochemical determination of dopamine, noradrenaline and serotonin in microdialysis samples.

J Chromatogr B Analyt Technol Biomed Life Sci 2015 Aug 2;998-999:63-71. Epub 2015 Jul 2.

Department of Pharmaceutical Chemistry and Drug Analysis, Center for Neurosciences, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Jette, Belgium. Electronic address:

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August 2015

Hypotensive and sympathoinhibitory responses to selective central AT2 receptor stimulation in spontaneously hypertensive rats.

Clin Sci (Lond) 2015 Jul;129(1):81-92

†Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information (FASC), Centre for Neurosciences C4N, Vrije Universiteit Brussel, Brussels, Belgium.

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July 2015

Absence of system xc- in mice decreases anxiety and depressive-like behavior without affecting sensorimotor function or spatial vision.

Prog Neuropsychopharmacol Biol Psychiatry 2015 Jun 23;59:49-58. Epub 2015 Jan 23.

Department of Pharmaceutical Chemistry and Drug Analysis, Center for Neurosciences, Vrije Universiteit Brussel, Brussels, Belgium. Electronic address:

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June 2015

Des-acyl ghrelin attenuates pilocarpine-induced limbic seizures via the ghrelin receptor and not the orexin pathway.

Neuropeptides 2015 Jun 8;51:1-7. Epub 2015 May 8.

Center for Neurosciences, Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information, Vrije Universiteit Brussel, Laarbeeklaan 103, Brussels 1090, Belgium. Electronic address:

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June 2015

The effect of vagus nerve stimulation on CSF monoamines and the PTZ seizure threshold in dogs.

Brain Stimul 2015 Jan-Feb;8(1):1-6. Epub 2014 Aug 8.

Department of Small Animal Medicine and Clinical Biology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B-9820 Merelbeke, Belgium.

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May 2015

Effects of AT1 receptor antagonism on kainate-induced seizures and concomitant changes in hippocampal extracellular noradrenaline, serotonin, and dopamine levels in Wistar-Kyoto and spontaneously hypertensive rats.

Epilepsy Behav 2015 May 23;46:66-71. Epub 2015 Apr 23.

Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information, Center for Neurosciences (C4N), Vrije Universiteit Brussel, Brussels, Belgium.

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May 2015

Nigral proteasome inhibition in mice leads to motor and non-motor deficits and increased expression of Ser129 phosphorylated α-synuclein.

Front Behav Neurosci 2015 31;9:68. Epub 2015 Mar 31.

Department of Pharmaceutical Biotechnology and Molecular Biology, Center for Neurosciences, Vrije Universiteit Brussel Brussels, Belgium.

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April 2015

Altered vesicular glutamate transporter expression in human temporal lobe epilepsy with hippocampal sclerosis.

Neurosci Lett 2015 Mar 7;590:184-8. Epub 2015 Feb 7.

Department of Pharmaceutical Biotechnology and Molecular Biology, Center for Neurosciences, Vrije Universiteit Brussel, Brussels, Belgium.

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March 2015

Neuropeptide FF and prolactin-releasing peptide decrease cortical excitability through activation of NPFF receptors.

Epilepsia 2015 Mar 12;56(3):489-98. Epub 2015 Feb 12.

Laboratory for Clinical and Experimental Neurophysiology, Neurobiology and Neuropsychology, Department of Neurology, Ghent University Hospital, Ghent University, Ghent, Belgium.

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March 2015

NMDA receptor antagonism potentiates the L-DOPA-induced extracellular dopamine release in the subthalamic nucleus of hemi-parkinson rats.

Neuropharmacology 2014 Oct 24;85:198-205. Epub 2014 May 24.

Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information, Center for Neuroscience, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090 Brussels, Belgium. Electronic address:

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October 2014

Strategies to reduce aspecific adsorption of peptides and proteins in liquid chromatography-mass spectrometry based bioanalyses: an overview.

J Chromatogr A 2014 Sep 30;1358:1-13. Epub 2014 Jun 30.

Department of Pharmaceutical Chemistry and Drug Analysis, Center for Neurosciences (C4N), Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium. Electronic address:

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September 2014

Cortistatin-14 mediates its anticonvulsant effects via sst2 and sst3 but not ghrelin receptors.

CNS Neurosci Ther 2014 Jul 31;20(7):662-70. Epub 2014 Mar 31.

Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information, Research Group Experimental Pharmacology, Center for Neurosciences (C4N), Vrije Universiteit Brussel, Brussels, Belgium.

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July 2014

Role(s) of the 5-HT2C receptor in the development of maximal dentate activation in the hippocampus of anesthetized rats.

CNS Neurosci Ther 2014 Jul;20(7):651-61

Dipartimento di Biomedicina Sperimentale e Neuroscienze Cliniche, Università degli Studi di Palermo, Palermo, Italy; Istituto Euro-Mediterraneo di Scienza e Tecnologia (IEMEST), Palermo, Italy.

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July 2014

Rewarding, reinforcing and incentive salient events involve orexigenic hypothalamic neuropeptides regulating mesolimbic dopaminergic neurotransmission.

Eur J Pharm Sci 2014 Jun 25;57:2-10. Epub 2014 Jan 25.

Center for Neurosciences C4N, Vrije Universiteit Brussel, Faculty of Medicine and Pharmacy, Department FASC, Laarbeeklaan 103, 1090 Brussels, Belgium. Electronic address:

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June 2014

Angiotensin II type 2 receptor-mediated and nitric oxide-dependent renal vasodilator response to compound 21 unmasked by angiotensin-converting enzyme inhibition in spontaneously hypertensive rats in vivo.

Hypertension 2013 Nov 16;62(5):920-6. Epub 2013 Sep 16.

Department of Pharmacology, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090 Brussels, Belgium.

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November 2013

Validation of the zebrafish pentylenetetrazol seizure model: locomotor versus electrographic responses to antiepileptic drugs.

PLoS One 2013 14;8(1):e54166. Epub 2013 Jan 14.

Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, University of Leuven, Leuven, Belgium.

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August 2013

Are vesicular neurotransmitter transporters potential treatment targets for temporal lobe epilepsy?

Front Cell Neurosci 2013 Aug 30;7:139. Epub 2013 Aug 30.

Center for Neurosciences, Vrije Universiteit Brussel Brussels, Belgium.

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August 2013

Antidepressant-like effects of oxytocin in mice are dependent on the presence of insulin-regulated aminopeptidase.

Int J Neuropsychopharmacol 2013 Jun 26;16(5):1153-63. Epub 2012 Nov 26.

Department of Pharmaceutical Chemistry and Drug Analysis, Center for Neurosciences, Vrije Universiteit Brussel, Brussels, Belgium.

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June 2013

L-Theanine intake increases threshold for limbic seizures but decreases threshold for generalized seizures.

Nutr Neurosci 2013 Mar 4;16(2):78-82. Epub 2012 Dec 4.

Department of Pharmaceutical Chemistry and Drug Analysis, Center for Neurosciences, Vrije Universiteit Brussel, Brussels, Belgium.

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March 2013

Inactivation of the constitutively active ghrelin receptor attenuates limbic seizure activity in rodents.

Neurotherapeutics 2012 Jul;9(3):658-72

Center for Neurosciences, Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium.

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July 2012

The antidepressants citalopram and reboxetine reduce seizure frequency in rats with chronic epilepsy.

Epilepsia 2012 May 16;53(5):870-8. Epub 2012 Mar 16.

Center for Neurosciences, Department of Pharmaceutical Chemistry and Drug Analysis, Vrije Universiteit Brussel, Laarbeeklaan 103, Brussels, Belgium.

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May 2012

Ghrelin: an emerging new anticonvulsant neuropeptide.

Epilepsia 2012 Apr 14;53(4):585-95. Epub 2012 Mar 14.

Center for Neurosciences, Department of Pharmaceutical Chemistry & Drug Analysis, Vrije Universiteit Brussel, Brussels, Belgium.

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April 2012

Neuropeptide Y increases in vivo hippocampal extracellular glutamate levels through Y1 receptor activation.

Neurosci Lett 2012 Feb 17;510(2):143-7. Epub 2012 Jan 17.

Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information, Center for Neuroscience, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium.

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February 2012

Rat hippocampal somatostatin sst3 and sst4 receptors mediate anticonvulsive effects in vivo: indications of functional interactions with sst2 receptors.

Neuropharmacology 2011 Dec 16;61(8):1327-33. Epub 2011 Aug 16.

Center for Neuroscience, Department of Pharmaceutical Chemistry and Drug Analysis, CePhar, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium.

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December 2011

Assessment of the convulsant liability of antidepressants using zebrafish and mouse seizure models.

Epilepsy Behav 2011 Nov 1;22(3):450-60. Epub 2011 Oct 1.

Department of Pharmaceutical Chemistry and Drug Analysis, Center for Neuroscience, Vrije Universiteit Brussel, Brussels, Belgium.

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November 2011

Region- and age-specific changes in glutamate transport in the AβPP23 mouse model for Alzheimer's disease.

J Alzheimers Dis 2011 ;24(2):287-300

Research Group Experimental Pharmacology, Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information, Centre of Pharmaceutical Research, Vrije Universiteit Brussel, Brussel, Belgium.

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August 2011

Blood pressure and renal hemodynamic effects of angiotensin fragments.

Hypertens Res 2011 Jun 17;34(6):674-83. Epub 2011 Mar 17.

Department of Pharmacology, Brussels, Belgium.

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June 2011

The absolute quantification of endogenous levels of brain neuropeptides in vivo using LC-MS/MS.

Bioanalysis 2011 Jun;3(11):1271-85

Vrije Universiteit Brussel, Department of Pharmaceutical Chemistry, Drug Analysis & Drug Information, Center for Neuroscience, Laarbeeklaan 103, B-1090 Brussels, Belgium.

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June 2011

Dopaminergic neurons of system x(c)⁻-deficient mice are highly protected against 6-hydroxydopamine-induced toxicity.

FASEB J 2011 Apr 29;25(4):1359-69. Epub 2010 Dec 29.

Department of Pharmaceutical Chemistry and Drug Analysis, Research Group Experimental Pharmacology, Vrije Universiteit Brussel, Brussels, Belgium.

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April 2011

Pharmacological and neurochemical characterization of the involvement of hippocampal adrenoreceptor subtypes in the modulation of acute limbic seizures.

J Neurochem 2010 Dec 19;115(6):1595-607. Epub 2010 Nov 19.

Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information, Research Group Experimental Pharmacology, Vrije Universiteit Brussel, Brussels, Belgium.

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December 2010

Revisiting the complex influences of cannabinoids on motor functions unravels pharmacodynamic differences between cannabinoid agonists.

Neuropharmacology 2010 Nov 13;59(6):503-10. Epub 2010 Jul 13.

Unité de Chimie Pharmaceutique et de Radiopharmacie, Université Catholique de Louvain, B-1200 Brussels, Belgium.

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November 2010

Astrocytic beta(2)-adrenergic receptors: from physiology to pathology.

Prog Neurobiol 2010 Jul 4;91(3):189-99. Epub 2010 Feb 4.

Department of Pharmaceutical Chemistry and Drug Analysis, Vrije Universiteit Brussel, Belgium.

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July 2010

The control of kainic acid-induced status epilepticus.

Epilepsy Res 2010 Jun;90(1-2):164-6

Department of Pharmaceutical Chemistry and Drug Analysis, Research Group Experimental Pharmacology, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium.

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June 2010

Renal vasoconstrictor and pressor responses to angiotensin IV in mice are AT1a-receptor mediated.

J Hypertens 2010 Mar;28(3):487-94

Department of Pharmacology, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090-Brussels, Belgium.

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March 2010

Involvement of the AT1 receptor subtype in the effects of angiotensin IV and LVV-haemorphin 7 on hippocampal neurotransmitter levels and spatial working memory.

J Neurochem 2010 Mar 17;112(5):1223-34. Epub 2009 Dec 17.

Research Group Experimental Pharmacology, Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information, Vrije Universiteit Brussel, Brussels, Belgium.

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March 2010

Hippocampal sst(1) receptors are autoreceptors and do not affect seizures in rats.

Neuroreport 2010 Mar;21(4):254-8

Department of Pharmaceutical Chemistry, Research Group Experimental Neuropharmacology, Drug Analysis and Drug Information, Vrije Universiteit Brussel, Brussels, Belgium.

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March 2010

Intrastrain differences in seizure susceptibility, pharmacological response and basal neurochemistry of Wistar rats.

Epilepsy Res 2009 Dec 14;87(2-3):234-46. Epub 2009 Oct 14.

Department of Pharmaceutical Chemistry, Drug Analysis & Drug Information, Vrije Universiteit Brussel, Brussels, Belgium.

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December 2009

Prediction of antiepileptic drug efficacy: the use of intracerebral microdialysis to monitor biophase concentrations.

Expert Opin Drug Metab Toxicol 2009 Oct;5(10):1267-77

Vrije Universiteit Brussel (VUB), Pharmaceutical Institute, Research Group Experimental Pharmacology, Department of Pharmaceutical Chemistry and Drug Analysis (labo FASC), Laarbeeklaan 103, Building G, 1090 Brussels, Belgium.

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October 2009

Validation of bioanalytical LC-MS/MS assays: evaluation of matrix effects.

J Chromatogr B Analyt Technol Biomed Life Sci 2009 Aug 13;877(23):2198-207. Epub 2009 Jan 13.

Vrije Universiteit Brussel, Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information, Laarbeeklaan 103, 1090 Brussels, Belgium.

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August 2009

vGLUT2 heterozygous mice show more susceptibility to clonic seizures induced by pentylenetetrazol.

Neurochem Int 2009 Jul-Aug;55(1-3):41-4. Epub 2009 Jan 8.

Department of Pharmaceutical Chemistry, Research Group Experimental Pharmacology, Vrije Universiteit Brussel, Brussels, Belgium.

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July 2009

Angiotensin IV and LVV-haemorphin 7 enhance spatial working memory in rats: effects on hippocampal glucose levels and blood flow.

Neurobiol Learn Mem 2009 Jul 20;92(1):19-26. Epub 2009 Feb 20.

Research Group Experimental Pharmacology, Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information, Vrije Universiteit Brussel, Brussels, Belgium.

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July 2009

Ang II and Ang IV: unraveling the mechanism of action on synaptic plasticity, memory, and epilepsy.

CNS Neurosci Ther 2008 ;14(4):315-39

Research Group Experimental Pharmacology, Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information, Vrije Universiteit Brussel, Brussels, Belgium.

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February 2009

High-affinity Na+/K+-dependent glutamate transporter EAAT4 is expressed throughout the rat fore- and midbrain.

J Comp Neurol 2008 Nov;511(2):155-72

Department of Pharmaceutical Chemistry and Drug Analysis, Research Group of Experimental Pharmacology, Vrije Universiteit Brussel, Brussels, Belgium.

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November 2008

Time-dependent changes in striatal xCT protein expression in hemi-Parkinson rats.

Neuroreport 2008 Oct;19(16):1589-92

Department of Pharmaceutical Chemistry and Drug Analysis, Research Group Experimental Pharmacology, Vrije Universiteit Brussel, Brussels, Belgium.

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October 2008

Critical Evaluation of Acetylcholine Determination in Rat Brain Microdialysates using Ion-Pair Liquid Chromatography with Amperometric Detection.

Sensors (Basel) 2008 Aug 28;8(8):5171-5185. Epub 2008 Aug 28.

Experimental Neuropharmacology Research Group, Department of Pharmaceutical Chemistry and Drug Analysis, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussel, Belgium.

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August 2008

Direct enhancement of hippocampal dopamine or serotonin levels as a pharmacodynamic measure of combined antidepressant-anticonvulsant action.

Neuropharmacology 2008 May 1;54(6):1017-28. Epub 2008 Apr 1.

Department of Pharmaceutical Chemistry, Drug Analysis & Drug Information, Research Group on Experimental Pharmacology, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium.

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May 2008

Brain and peripheral angiotensin II type 1 receptors mediate renal vasoconstrictor and blood pressure responses to angiotensin IV in the rat.

J Hypertens 2008 May;26(5):998-1007

Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information, Vrije Universiteit Brussel, Brussels, Belgium.

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May 2008

Quantitative liquid chromatography/mass spectrometry for the analysis of microdialysates.

Talanta 2008 Jan 2;74(4):458-69. Epub 2007 Aug 2.

Research Group Experimental Pharmacology, Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium.

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January 2008