Iain C Macaulay

Iain C Macaulay

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Iain C Macaulay

Iain C Macaulay

Publications by authors named "Iain C Macaulay"

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36Publications

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Defining Cell Identity with Single-Cell Omics.

Proteomics 2018 09 28;18(18):e1700312. Epub 2018 May 28.

Earlham Institute, Norwich Research Park, Norwich, NR4 7UZ, United Kingdom.

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http://dx.doi.org/10.1002/pmic.201700312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175476PMC
September 2018

Pluripotent state transitions coordinate morphogenesis in mouse and human embryos.

Nature 2017 12 29;552(7684):239-243. Epub 2017 Nov 29.

Mammalian Embryo and Stem Cell Group, University of Cambridge, Department of Physiology, Development and Neuroscience, Downing Street, Cambridge CB2 3EG, UK.

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http://dx.doi.org/10.1038/nature24675DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768241PMC
December 2017

Proliferation Drives Aging-Related Functional Decline in a Subpopulation of the Hematopoietic Stem Cell Compartment.

Cell Rep 2017 05;19(8):1503-1511

Cambridge Institute for Medical Research, University of Cambridge, Cambridge, Cambridgeshire CB2 0XY, UK; Department of Haematology, University of Cambridge, Cambridge, Cambridgeshire CB2 0XY, UK; Stem Cell Institute, University of Cambridge, Cambridge, Cambridgeshire CB2 0XY, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.04.074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457484PMC
May 2017

Power analysis of single-cell RNA-sequencing experiments.

Nat Methods 2017 Apr 6;14(4):381-387. Epub 2017 Mar 6.

European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.

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http://dx.doi.org/10.1038/nmeth.4220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376499PMC
April 2017

Single-Cell Multiomics: Multiple Measurements from Single Cells.

Trends Genet 2017 02 13;33(2):155-168. Epub 2017 Jan 13.

Sanger Institute - EBI Single-Cell Genomics Centre, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK; Department of Human Genetics, University of Leuven, KU Leuven, Leuven, 3000, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.tig.2016.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5303816PMC
February 2017

Separation and parallel sequencing of the genomes and transcriptomes of single cells using G&T-seq.

Nat Protoc 2016 11 29;11(11):2081-103. Epub 2016 Sep 29.

Sanger Institute-EBI Single-Cell Genomics Centre, Wellcome Trust Sanger Institute, Hinxton, UK.

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http://dx.doi.org/10.1038/nprot.2016.138DOI Listing
November 2016

Resolving early mesoderm diversification through single-cell expression profiling.

Nature 2016 07 6;535(7611):289-293. Epub 2016 Jul 6.

Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1038/nature18633DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947525PMC
July 2016

Integrin Based Isolation Enables Purification of Murine Lineage Committed Cardiomyocytes.

PLoS One 2015 31;10(8):e0135880. Epub 2015 Aug 31.

Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Lund, Sweden; Van Andel Research Institute, Grand Rapids, Michigan, United States of America; Spectrum Health Fredrik Meijer Heart and Vascular Institute, Grand Rapids, Michigan, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0135880PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556377PMC
May 2016

Heterogeneity in Oct4 and Sox2 Targets Biases Cell Fate in 4-Cell Mouse Embryos.

Cell 2016 Mar;165(1):61-74

Department of Physiology, Development & Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.01.047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819611PMC
March 2016

Single-Cell RNA-Sequencing Reveals a Continuous Spectrum of Differentiation in Hematopoietic Cells.

Cell Rep 2016 Feb 21;14(4):966-977. Epub 2016 Jan 21.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1HH, UK; Department of Haematology, University of Cambridge, Cambridge CB2 0PT, UK; Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute, Cambridge CB2 1QR, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.12.082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742565PMC
February 2016

G&T-seq: parallel sequencing of single-cell genomes and transcriptomes.

Nat Methods 2015 Jun 27;12(6):519-22. Epub 2015 Apr 27.

1] Sanger Institute-EBI Single-Cell Genomics Centre, Wellcome Trust Sanger Institute, Hinxton, UK. [2] Department of Human Genetics, University of Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1038/nmeth.3370DOI Listing
June 2015

Population and single-cell genomics reveal the Aire dependency, relief from Polycomb silencing, and distribution of self-antigen expression in thymic epithelia.

Genome Res 2014 Dec 15;24(12):1918-31. Epub 2014 Sep 15.

Paediatric Immunology, Department of Biomedicine, University of Basel, and The Basel University Children's Hospital, Basel, 4058, Switzerland; Developmental Immunology, Department of Paediatrics, and the Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, United Kingdom.

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http://dx.doi.org/10.1101/gr.171645.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4248310PMC
December 2014

Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo.

Cancer Cell 2014 Jun 15;25(6):794-808. Epub 2014 May 15.

Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK; Departments of Cell and Molecular Biology, Medicine Huddinge, and Laboratory Medicine, Huddinge, Karolinska Institutet and Center for Hematology and Regenerative Medicine, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.ccr.2014.03.036DOI Listing
June 2014

Single cell genomics: advances and future perspectives.

PLoS Genet 2014 Jan 30;10(1):e1004126. Epub 2014 Jan 30.

Single Cell Genomics Centre, Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom ; Laboratory of Reproductive Genomics, Department of Human Genetics, KU Leuven, Belgium.

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http://dx.doi.org/10.1371/journal.pgen.1004126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907301PMC
January 2014

Characterization of transcriptional networks in blood stem and progenitor cells using high-throughput single-cell gene expression analysis.

Nat Cell Biol 2013 Apr 24;15(4):363-72. Epub 2013 Mar 24.

Department of Haematology, Wellcome Trust and MRC Cambridge Stem Cell Institute and Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK.

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http://dx.doi.org/10.1038/ncb2709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3796878PMC
April 2013

Canonical Wnt signaling negatively regulates platelet function.

Proc Natl Acad Sci U S A 2009 Nov 9;106(47):19836-41. Epub 2009 Nov 9.

Conway Institute, School of Biomolecular and Biomedical Science, University College Dublin, Belfield, Dublin 4, Ireland.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0906268106
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http://dx.doi.org/10.1073/pnas.0906268106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2785253PMC
November 2009

Identification of variation in the platelet transcriptome associated with glycoprotein 6 haplotype.

Platelets 2008 Jun;19(4):258-67

Department of Haematology, University of Cambridge and National Health Service Blood and Transplant, Cambridge, UK.

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http://dx.doi.org/10.1080/09537100801947434DOI Listing
June 2008

The novel inhibitory receptor G6B is expressed on the surface of platelets and attenuates platelet function in vitro.

Blood 2007 Jun 20;109(11):4806-9. Epub 2007 Feb 20.

Department of Medicine, Cambridge Institute for Medical Research, University of Cambridge, Addembrookes Hospital, Hills Road, Cambridge, UK.

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http://dx.doi.org/10.1182/blood-2006-09-047449DOI Listing
June 2007

Platelet genomics and proteomics in human health and disease.

J Clin Invest 2005 Dec;115(12):3370-7

Department of Haematology, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1172/JCI26885DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1297260PMC
December 2005