Humam Kadara

Humam Kadara

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Humam Kadara

Humam Kadara

Publications by authors named "Humam Kadara"

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Genomic landscape of allelic imbalance in premalignant atypical adenomatous hyperplasias of the lung.

EBioMedicine 2019 Apr 21;42:296-303. Epub 2019 Mar 21.

Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2019.03.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491940PMC
April 2019

Genome-Wide and Phenotypic Evaluation of Stem Cell Progenitors Derived From -Deficient Murine Lung Adenocarcinoma With Somatic Mutations.

Front Oncol 2019 2;9:207. Epub 2019 Apr 2.

Department of Biochemistry and Molecular Genetics, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.

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http://dx.doi.org/10.3389/fonc.2019.00207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454871PMC
April 2019

Epigenetic Suppression of the T-box Subfamily 2 () in Human Non-Small Cell Lung Cancer.

Int J Mol Sci 2019 Mar 7;20(5). Epub 2019 Mar 7.

Department of Biochemistry and Molecular Genetics, Faculty of Medicine, American University of Beirut, Riad El Solh 1107 2020 Beirut, Lebanon.

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http://dx.doi.org/10.3390/ijms20051159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429281PMC
March 2019

Genomics of adult and pediatric solid tumors.

Am J Cancer Res 2018 1;8(8):1356-1386. Epub 2018 Aug 1.

Department of Pediatrics and Adolescent Medicine, Faculty of Medicine, American University of Beirut Beirut, Lebanon.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6129500PMC
August 2018

Mechanism of action of the atypical retinoid ST1926 in colorectal cancer: DNA damage and DNA polymerase α.

Am J Cancer Res 2018 1;8(1):39-55. Epub 2018 Jan 1.

Department of Biochemistry and Molecular Genetics, American University of BeirutBeirut, Lebanon.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5794720PMC
January 2018

Smoking and Lung Cancer: A Geo-Regional Perspective.

Front Oncol 2017 1;7:194. Epub 2017 Sep 1.

Faculty of Medicine, Department of Biochemistry and Molecular Genetics, American University of Beirut, Beirut, Lebanon.

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http://dx.doi.org/10.3389/fonc.2017.00194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585135PMC
September 2017

subfamily suppression in lung cancer pathogenesis: a high-potential marker for early detection.

Oncotarget 2017 Sep 4;8(40):68230-68241. Epub 2017 Aug 4.

Department of Biochemistry and Molecular Genetics, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.

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http://dx.doi.org/10.18632/oncotarget.19938DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620251PMC
September 2017

Early Events in the Molecular Pathogenesis of Lung Cancer.

Cancer Prev Res (Phila) 2016 Jul 22;9(7):518-27. Epub 2016 Mar 22.

Section of Computational Biomedicine, Boston University School of Medicine, Boston University, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1940-6207.CAPR-15-0400DOI Listing
July 2016

Radiotherapeutic bandage for the treatment of squamous cell carcinoma of the skin.

Nucl Med Biol 2016 06 17;43(6):333-8. Epub 2016 Mar 17.

Department of Chemistry, University of Texas at Dallas, 800 West Campbell Rd., Richardson, TX, 75080. Electronic address:

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http://dx.doi.org/10.1016/j.nucmedbio.2016.02.010DOI Listing
June 2016

LAPTM4B is associated with poor prognosis in NSCLC and promotes the NRF2-mediated stress response pathway in lung cancer cells.

Sci Rep 2015 Sep 7;5:13846. Epub 2015 Sep 7.

Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, U.S.A.

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http://dx.doi.org/10.1038/srep13846DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561374PMC
September 2015

Prediction of survival in resected non-small cell lung cancer using a protein expression-based risk model: implications for personalized chemoprevention and therapy.

Clin Cancer Res 2014 Apr 23;20(7):1946-54. Epub 2013 Dec 23.

Authors' Affiliations: Departments of Thoracic/Head and Neck Medical Oncology, Biostatistics, Pathology, and Thoracic and Cardiovascular Surgery, The University of Texas M.D. Anderson Cancer Center, Houston, Texas; Levine Cancer Center; Philips Digital Pathology; and Department of Pathology, University of San Francisco Xavier de Chuquisaca Sucre-Bolivia, San Francisco, California.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-1959DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018222PMC
April 2014

Transcriptomic architecture of the adjacent airway field cancerization in non-small cell lung cancer.

J Natl Cancer Inst 2014 Mar 22;106(3):dju004. Epub 2014 Feb 22.

Affiliations of authors: Department of Translational Molecular Pathology (HK, JF, TM, MMG, C-WC, ZC, GM, IIW), Department of Thoracic/Head and Neck Medical Oncology (MK, WKH, IIW), Department of Pathology (NK, CM), Department of Bioinformatics (S-YY, LS, JW, KRC), University of Texas MD Anderson Cancer Center, Houston, TX; Section of Computational Medicine, Department of Medicine, Boston University, Boston, MA (ACG, AS).

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http://dx.doi.org/10.1093/jnci/dju004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982778PMC
March 2014

EZH2 protein expression associates with the early pathogenesis, tumor progression, and prognosis of non-small cell lung carcinoma.

Clin Cancer Res 2013 Dec 4;19(23):6556-65. Epub 2013 Oct 4.

Authors' Affiliations: Departments of Thoracic/Head and Neck Medical Oncology, Pathology, Biostatistics, Thoracic Surgery, and Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas; and The University of Ottawa, Ottawa, Canada.

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http://dx.doi.org/10.1158/1078-0432.CCR-12-3946DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3890101PMC
December 2013

Field cancerization in non-small cell lung cancer: implications in disease pathogenesis.

Proc Am Thorac Soc 2012 May;9(2):38-42

Department of Thoracic/Head and Neck Medical Oncology , University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 085, Houston, TX 77030, USA.

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http://dx.doi.org/10.1513/pats.201201-004MSDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5821032PMC
May 2012

Pulmonary adenocarcinoma: a renewed entity in 2011.

Respirology 2012 Jan;17(1):50-65

Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

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http://dx.doi.org/10.1111/j.1440-1843.2011.02095.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3911779PMC
January 2012

Reuben Lotan, Ph.D. (1946-2011): in memoriam.

Authors:
Humam Kadara

Cancer Biol Ther 2011 Dec 15;12(12):1015-7. Epub 2011 Dec 15.

The University of Texas MD Anderson Cancer Center, Houston, TX USA.

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http://dx.doi.org/10.4161/cbt.12.12.18841DOI Listing
December 2011

Abnormalities of the TITF-1 lineage-specific oncogene in NSCLC: implications in lung cancer pathogenesis and prognosis.

Clin Cancer Res 2011 Apr 21;17(8):2434-43. Epub 2011 Jan 21.

Departmentsof Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-10-1412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078948PMC
April 2011

A five-gene and corresponding protein signature for stage-I lung adenocarcinoma prognosis.

Clin Cancer Res 2011 Mar 16;17(6):1490-501. Epub 2010 Dec 16.

Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-10-2703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079395PMC
March 2011

Comparative functional genomics analysis of NNK tobacco-carcinogen induced lung adenocarcinoma development in Gprc5a-knockout mice.

PLoS One 2010 Jul 29;5(7):e11847. Epub 2010 Jul 29.

Department of Thoracic/Head and Neck Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0011847PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912294PMC
July 2010

A Gprc5a tumor suppressor loss of expression signature is conserved, prevalent, and associated with survival in human lung adenocarcinomas.

Neoplasia 2010 Jun;12(6):499-505

Department of Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2887090PMC
http://dx.doi.org/10.1593/neo.10390DOI Listing
June 2010

Knockout of the tumor suppressor gene Gprc5a in mice leads to NF-kappaB activation in airway epithelium and promotes lung inflammation and tumorigenesis.

Cancer Prev Res (Phila) 2010 Apr 30;3(4):424-37. Epub 2010 Mar 30.

Department of Thoracic/Head and Neck Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1158/1940-6207.CAPR-10-0032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678967PMC
April 2010

Differential inhibition of protein translation machinery by curcumin in normal, immortalized, and malignant oral epithelial cells.

Cancer Prev Res (Phila) 2010 Mar 9;3(3):331-8. Epub 2010 Feb 9.

Department of Thoracic/Head and Neck Medical Oncology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

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http://dx.doi.org/10.1158/1940-6207.CAPR-09-0076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2833226PMC
March 2010

Expression of interleukin-1 receptor-associated kinase-1 in non-small cell lung carcinoma and preneoplastic lesions.

Clin Cancer Res 2010 Jan 22;16(1):34-44. Epub 2009 Dec 22.

Departmentsof Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030-4009, USA.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-09-0650DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811365PMC
January 2010

Identification of gene signatures and molecular markers for human lung cancer prognosis using an in vitro lung carcinogenesis system.

Cancer Prev Res (Phila) 2009 Aug 28;2(8):702-11. Epub 2009 Jul 28.

Departments of Thoracic/Head and Neck MedicalOncology, M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

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http://dx.doi.org/10.1158/1940-6207.CAPR-09-0084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382104PMC
August 2009

Activation of protein kinase C by phorbol 12-myristate 13-acetate suppresses the growth of lung cancer cells through KLF6 induction.

Cancer Biol Ther 2009 May 17;8(9):801-7. Epub 2009 May 17.

Department of Thoracic/Head and Neck Medical Oncology, University of Texas, M.D. Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.4161/cbt.8.9.8186DOI Listing
May 2009

Involvement of Rac in fenretinide-induced apoptosis.

Cancer Res 2008 Jun;68(11):4416-23

Department of Thoracic/Head and Neck Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-0031DOI Listing
June 2008

Ursolic acid inhibits STAT3 activation pathway leading to suppression of proliferation and chemosensitization of human multiple myeloma cells.

Mol Cancer Res 2007 Sep;5(9):943-55

Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Box 143, Houston, TX 77030, USA.

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http://dx.doi.org/10.1158/1541-7786.MCR-06-0348DOI Listing
September 2007

Induction of endoplasmic reticulum stress by the pro-apoptotic retinoid N-(4-hydroxyphenyl)retinamide via a reactive oxygen species-dependent mechanism in human head and neck cancer cells.

Cancer Biol Ther 2007 May 3;6(5):705-11. Epub 2007 Feb 3.

Department of Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.4161/cbt.6.5.3963DOI Listing
May 2007

Induction of GDF-15/NAG-1/MIC-1 in human lung carcinoma cells by retinoid-related molecules and assessment of its role in apoptosis.

Cancer Biol Ther 2006 May 13;5(5):518-22. Epub 2006 May 13.

Department of Thoracic/Head and Neck Medical Oncology, The University of Texas, MD Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.4161/cbt.5.5.2602DOI Listing
May 2006