Prof. Hermis Iatrou, PhD - University of Athens - Professor

Prof. Hermis Iatrou

PhD

University of Athens

Professor

Athens | Greece

Main Specialties: Chemistry, Pharmacology

Additional Specialties: Drug Delivery, Gene Delivery, Synthesis of Polypeptides

ORCID logohttps://orcid.org/0000-0001-9358-0769


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Prof. Hermis Iatrou, PhD - University of Athens - Professor

Prof. Hermis Iatrou

PhD

Introduction

http://users.uoa.gr/~iatrou/index.html/web/

Primary Affiliation: University of Athens - Athens , Greece

Specialties:

Additional Specialties:

Research Interests:


View Prof. Hermis Iatrou’s Resume / CV

Education

Feb 1997
University of Alabama at Birmingham, USA
POST-DOC FELOW
Jul 1995
Forschungszentrum Juelich, Germany
POST-DOC FELOW
Dec 1993
National and Kapodistrian University of Athens, Greece
PhD in Polymer Chemistry
Sep 1989
National and Kapodistrian University of Athens, Greece
Bachelor in Chemistry
Aug 1997
University of Alabama at Birmingham
Feb 1994
Forschungszentrum Jülich

Experience

Apr 2002
National and Kapodistrian University of Athens
PROFESSOR
CHEMISTRY

Publications

18Publications

365Reads

1Profile Views

45PubMed Central Citations

Self-Healing pH- and Enzyme Stimuli-Responsive Hydrogels for Targeted Delivery of Gemcitabine To Treat Pancreatic Cancer.

Biomacromolecules 2018 09 27;19(9):3840-3852. Epub 2018 Aug 27.

Department of Chemistry , University of Athens , Panepistimiopolis , Zografou , Athens 15771 , Greece.

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http://pubs.acs.org/doi/10.1021/acs.biomac.8b00959
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http://dx.doi.org/10.1021/acs.biomac.8b00959DOI Listing
September 2018
107 Reads
5.750 Impact Factor

Smart polymersomes and hydrogels from polypeptide-based polymersystems through -amino acid N-carboxyanhydride ring-openingpolymerization. From chemistry to biomedical applications

Progress in Polymer Science 83 (2018) 28–78

Progress in Polymer Science

The synthesis of smart stimuli-responsive polymeric materials for nanomedicine applications hasattracted the interest of a large number of scientists that focuses on the effective encapsulation of pharma-ceutical compounds and control of their biodistribution. The development of multifunctional polymericmaterials is mainly guided by the goal of achieving active compounds which selectively target the pathological sites, therefore minimizing systemic side effects. These materials are divided in two cate-gories based on their mode of administration: the first is based on systemic administration, while thesecond relies on localized mode of action. Polymersomes are nanocarriers that are delivered through theblood compartment and are the best systems to carry both hydrophilic drugs in their interior hollowspace or/and hydrophobic drugs encapsulated in their hydrophobic layer. Polymeric hydrogels on theother hand are systems for localized drug delivery of both kinds of pharmaceuticals, depending on theirsolubility. Even though a large number of polymeric materials that form either nanocarrier or hydrogeldelivery systems has been investigated, a surprisingly small subset of these technologies has demon-strated potentially curative preclinical results, and fewer have progressed towards commercialization.One of the most promising classes of polymeric materials for drug delivery applications is polypeptides,which combine the properties of the conventional polymers with the 3D structure of natural proteinssuch as -helices and ˇ-sheets. In this article, the synthetic pathways followed to develop well-definedstimuli-responsive polymer delivery systems based on polypeptides that have been prepared throughring-opening polymerization (ROP) of N-carboxyanhydrides are reviewed, including a discussion of theirin vivo and in vitro efficacy. This review is limited to systems presented over the last eighteen years.

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May 2018
48 Reads

Self-Assembly of Telechelic Tyrosine End-Capped PEO and Poly(alanine) Polymers in Aqueous Solution.

Biomacromolecules 2016 Mar 25;17(3):1186-97. Epub 2016 Feb 25.

University of Athens , Department of Chemistry, Panepistimiopolis Zografou, 157 71 Athens, Greece.

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http://dx.doi.org/10.1021/acs.biomac.6b00023DOI Listing
March 2016
25 Reads
5.750 Impact Factor

Complexation-Driven Mutarotation in Poly(L-proline) Block Copolypeptides.

Biomacromolecules 2015 Nov 20;16(11):3686-93. Epub 2015 Oct 20.

Molecular Materials, Department of Applied Physics, Aalto University School of Science and Technology (previously Helsinki University of Technology), FIN-00076 Aalto, Espoo, Finland.

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http://dx.doi.org/10.1021/acs.biomac.5b01198DOI Listing
November 2015
14 Reads
1 Citation
5.750 Impact Factor

Extended self-assembled long periodicity and Zig-Zag domains from helix-helix diblock copolymer Poly(γ-benzyl-l-glutamate)-block-poly(O-benzyl-l-hydroxyproline).

Biomacromolecules 2014 Nov 7;15(11):3923-30. Epub 2014 Oct 7.

University of Athens , Department of Chemistry, Panepistimiopolis, Zografou, 15771 Athens, Greece.

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http://dx.doi.org/10.1021/bm5009734DOI Listing
November 2014
19 Reads
1 Citation
5.750 Impact Factor

Polymersomes from polypeptide containing triblock Co- and terpolymers for drug delivery against pancreatic cancer: asymmetry of the external hydrophilic blocks.

Macromol Biosci 2014 Sep 19;14(9):1222-38. Epub 2014 May 19.

University of Athens, Chemistry Department, Panepistimiopolis, Zografou, 15771, Athens, Greece.

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http://dx.doi.org/10.1002/mabi.201400137DOI Listing
September 2014
13 Reads
2 Citations
3.851 Impact Factor

Self-assembly of a model peptide incorporating a hexa-histidine sequence attached to an oligo-alanine sequence, and binding to gold NTA/nickel nanoparticles.

Biomacromolecules 2014 Sep 18;15(9):3412-20. Epub 2014 Aug 18.

Department of Chemistry, University of Reading , Whiteknights, Reading RG6 6AD, United Kingdom.

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http://dx.doi.org/10.1021/bm500950cDOI Listing
September 2014
26 Reads
4 Citations
5.750 Impact Factor

Double smectic self-assembly in block copolypeptide complexes.

Biomacromolecules 2012 Nov 18;13(11):3572-80. Epub 2012 Oct 18.

Molecular Materials, Department of Applied Physics, Aalto University School of Science (formerly Helsinki University of Technology), P.O. Box 15100, FI-02015 Espoo, Finland.

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http://dx.doi.org/10.1021/bm3010275DOI Listing
November 2012
15 Reads
5.750 Impact Factor

Well-defined homopolypeptides, copolypeptides, and hybrids of poly(l-proline).

Biomacromolecules 2011 Jun 25;12(6):2396-406. Epub 2011 May 25.

University of Athens, Chemistry Department, Panepistimiopolis, Zografou, Athens, Greece.

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http://dx.doi.org/10.1021/bm200495nDOI Listing
June 2011
11 Reads
1 Citation
5.750 Impact Factor

Self-assembled polymeric supramolecular frameworks.

Angew Chem Int Ed Engl 2011 Mar 14;50(11):2516-20. Epub 2011 Feb 14.

Department of Applied Physics, Aalto University School of Science and Technology, P.O.Box 15100, 00076 Espoo, Finland.

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http://dx.doi.org/10.1002/anie.201007185DOI Listing
March 2011
19 Reads
3 Citations
11.261 Impact Factor

Solid state nanofibers based on self-assemblies: from cleaving from self-assemblies to multilevel hierarchical constructs.

Faraday Discuss 2009 ;143:95-107; discussion 169-86

Department of Applied Physics, Helsinki University of Technology, FIN-02015 TKK Espoo, Finland.

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May 2010
26 Reads
4.610 Impact Factor

Synthesis of well-defined polypeptide-based materials via the ring-opening polymerization of alpha-amino acid N-carboxyanhydrides.

Chem Rev 2009 Nov;109(11):5528-78

Department of Chemistry, University of Athens, Panepistimiopolis, Zografou 15771, Athens, Greece.

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http://dx.doi.org/10.1021/cr900049tDOI Listing
November 2009
14 Reads
13 Citations
45.661 Impact Factor

Complex macromolecular chimeras.

Biomacromolecules 2008 Jul 12;9(7):2072-80. Epub 2008 Jun 12.

Department of Chemistry, University of Athens, Panepistimiopolis, Zografou, Athens, Greece.

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http://dx.doi.org/10.1021/bm800316wDOI Listing
July 2008
14 Reads
5.750 Impact Factor

Architecturally induced multiresponsive vesicles from well-defined polypeptides: formation of gene vehicles.

Biomacromolecules 2007 Jul 21;8(7):2173-81. Epub 2007 Jun 21.

Chemistry Department, University of Athens, Panepistimiopolis Zografou, Athens, Greece.

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http://dx.doi.org/10.1021/bm070360fDOI Listing
July 2007
14 Reads
3 Citations
5.750 Impact Factor

Hierarchical ionic self-assembly of rod-comb block copolypeptide-surfactant complexes.

Biomacromolecules 2006 Dec;7(12):3379-84

Department of Engineering Physics and Mathematics and Center for New Materials, Helsinki University of Technology, P.O. Box 2200, FIN-02015 HUT, Espoo, Finland.

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http://dx.doi.org/10.1021/bm0606770DOI Listing
December 2006
17 Reads
5.750 Impact Factor

The effect of molecular architecture on the grain growth kinetics of AnBn star block copolymers.

Faraday Discuss 2005 ;128:103-12; Discussion 211-29

Polymer Science and Engineering Department, University of Massachusetts, Amherst, Massachusetts 01003, USA.

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March 2005
9 Reads
1 Citation
4.610 Impact Factor

Micellization in pH-sensitive amphiphilic block copolymers in aqueous media and the formation of metal nanoparticles.

Faraday Discuss 2005 ;128:129-47

Institute of Electronic Structure and Laser, Foundation for Research and Technology-Hellas, Heraklion Crete, Greece.

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March 2005
12 Reads
1 Citation
4.610 Impact Factor

Living polypeptides.

Biomacromolecules 2004 Sep-Oct;5(5):1653-6

Department of Chemistry, University of Athens, Panepistimiopolis, Zografou, 15771, Greece.

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http://dx.doi.org/10.1021/bm0497217DOI Listing
February 2005
10 Reads
15 Citations
5.750 Impact Factor