Heikki Joensuu

Heikki Joensuu

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Heikki Joensuu

Publications by authors named "Heikki Joensuu"

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A Novel Anti-HER2 Antibody-Drug Conjugate XMT-1522 for HER2-Positive Breast and Gastric Cancers Resistant to Trastuzumab Emtansine.

Mol Cancer Ther 2019 Oct 10;18(10):1721-1730. Epub 2019 Jul 10.

Translational Cancer Medicine Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1158/1535-7163.MCT-19-0207DOI Listing
October 2019

Challenges of international oncology trial collaboration-a call to action.

Br J Cancer 2019 Oct 5;121(7):515-521. Epub 2019 Aug 5.

Alfred Health and the School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.

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http://dx.doi.org/10.1038/s41416-019-0532-4DOI Listing
October 2019

Boron neutron capture therapy for locally recurrent head and neck squamous cell carcinoma: An analysis of dose response and survival.

Radiother Oncol 2019 Aug 17;137:153-158. Epub 2019 May 17.

Department of Oncology, Helsinki University Hospital and University of Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.radonc.2019.04.033DOI Listing
August 2019

Radium-223 in combination with paclitaxel in cancer patients with bone metastases: safety results from an open-label, multicenter phase Ib study.

Eur J Nucl Med Mol Imaging 2019 May 13;46(5):1092-1101. Epub 2018 Dec 13.

Oncology Division, Rambam Health Care Campus, 8 Ha'Aliya Hashniya, and Technion - Israel Institute of Technology, 1 Efron Street, Haifa, Israel.

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http://dx.doi.org/10.1007/s00259-018-4234-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451720PMC
May 2019

Trastuzumab Therapy for 9 Weeks vs 1 Year for Human Epidermal Growth Factor 2-Positive Breast Cancer-Reply.

JAMA Oncol 2019 Jan;5(1):118

Department of Oncology, Helsinki University Hospital, Helsinki University, Helsinki, Finland.

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http://dx.doi.org/10.1001/jamaoncol.2018.5739DOI Listing
January 2019

Drug-Sensitivity Screening and Genomic Characterization of 45 HPV-Negative Head and Neck Carcinoma Cell Lines for Novel Biomarkers of Drug Efficacy.

Mol Cancer Ther 2018 09 3;17(9):2060-2071. Epub 2018 Jul 3.

Research Programs Unit, Genome-Scale Biology Program and Medicum, Biochemistry and Developmental Biology, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1158/1535-7163.MCT-17-0733DOI Listing
September 2018

Prognostic value of isolated tumour cells in sentinel lymph nodes in early-stage breast cancer: a prospective study.

Br J Cancer 2018 05 24;118(11):1529-1535. Epub 2018 Apr 24.

Comprehensive Cancer Center, Breast Surgery Unit, Helsinki University Hospital and University of Helsinki, P.O. Box 263, FIN-00029 HUS, Helsinki, Finland.

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http://dx.doi.org/10.1038/s41416-018-0052-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988733PMC
May 2018

Cancer-derived exosomes from HER2-positive cancer cells carry trastuzumab-emtansine into cancer cells leading to growth inhibition and caspase activation.

BMC Cancer 2018 05 2;18(1):504. Epub 2018 May 2.

Department of Oncology, Helsinki University Hospital and University of Helsinki, Haartmaninkatu 4, FIN-00029, Helsinki, Finland.

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http://dx.doi.org/10.1186/s12885-018-4418-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5930687PMC
May 2018

Clinical relevance of integrin alpha 4 in gastrointestinal stromal tumours.

J Cell Mol Med 2018 04 29;22(4):2220-2230. Epub 2018 Jan 29.

Laboratory of Molecular Oncology, Translational Cancer Biology Program, Department of Oncology, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1111/jcmm.13502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867167PMC
April 2018

Tumor PIK3CA Genotype and Prognosis in Early-Stage Breast Cancer: A Pooled Analysis of Individual Patient Data.

J Clin Oncol 2018 04 22;36(10):981-990. Epub 2018 Feb 22.

Dimitrios Zardavas and Debora Fumagalli, Breast International Group; Christos Sotiriou, Université Libre de Bruxelles, Brussels, Belgium; Luc te Marvelde and Roger L. Milne, Cancer Council; Roger L. Milne and Sherene Loi, University of Melbourne, Melbourne; Barry Iacopetta, University of Western Australia, Western Australia; Sandra O'Toole and Elena Lopez-Knowles, Garvan Institute of Medical Research, Darlinghurst, Australia; George Fountzilas and Vassiliki Kotoula, Hellenic Foundation for Cancer Research/Aristotle University of Thessaloniki, Thessaloniki; Evangelia Razis, Hygeia Hospital; George Papaxoinis, Hippokration Hospital, Athens, Greece; Heikki Joensuu, Helsinki University Hospital and University of Helsinki, Helsinki, Finland; Mary Ellen Moynahan, Memorial Sloan Kettering Cancer Center, New York, NY; Bryan T. Hennessy, Beaumont Hospital and Royal College of Surgeons, Dublin, Ireland; Ivan Bieche, Curie Institut, Paris; Thomas Bachelot, Centre de Recherche en Cancérologie de Lyon, Lyon; Stefan Michiels, Gustave Roussy and Inserm, Univ. Paris-Sud, Univ. Paris-Saclay, Villejuif, France; Lao H. Saal, Lund University, Lund; Olle Stal, Qing Wang, and Gizeh Perez-Tenorio, Linköping University, Linköping, Sweden; Jeanette Dupont Jensen, University of Southern Denmark, on behalf of the Danish Breast Cancer Cooperative Group, Odense, Denmark; Elena Lopez-Knowles, Royal Marsden NHS Trust and Institute of Cancer Research, London; Daniel W. Rea, University of Birmingham, Birmingham, United Kingdom; Mattia Barbaraeschi, Santa Chiara Hospital, Trento, Italy; Shinzaburo Noguchi, Osaka University, Osaka Japan; Hatem A. Azim Jr, American University of Beirut (AUB), Beirut, Lebanon; Enrique Lerma, Universitat Autònoma de Barcelona, Barcelona, Spain; Cornelis J.H. can de Velde, Leiden University Medical Center, Leiden, the Netherlands; Vicky Sabine, University of Guelph, Guelph; John M.S. Bartlett, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1200/JCO.2017.74.8301DOI Listing
April 2018

Taxane Followed by Anthracycline or Vice Versa: Impact of Sequential Order on Breast Cancer Recurrence?-Reply.

JAMA Oncol 2018 03;4(3):423-424

Uppsala University Hospital, Uppsala, Sweden.

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http://dx.doi.org/10.1001/jamaoncol.2017.3352DOI Listing
March 2018

Gastrointestinal Stromal Tumors.

J Clin Oncol 2018 01 8;36(2):136-143. Epub 2017 Dec 8.

Margaret von Mehren, Fox Chase Cancer Center, Philadelphia, PA; and Heikki Joensuu, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1200/JCO.2017.74.9705DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6553810PMC
January 2018

CD73 Promotes Resistance to HER2/ErbB2 Antibody Therapy.

Cancer Res 2017 10 30;77(20):5652-5663. Epub 2017 Aug 30.

Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Québec, Canada.

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http://dx.doi.org/10.1158/0008-5472.CAN-17-0707DOI Listing
October 2017

Correlation of c-Met Expression and Outcome in Patients With Renal Cell Carcinoma Treated With Sunitinib.

Clin Genitourin Cancer 2017 08 1;15(4):487-494. Epub 2017 Feb 1.

Comprehensive Cancer Center, Helsinki University Hospital, Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.clgc.2017.01.021DOI Listing
August 2017

SLUG transcription factor: a pro-survival and prognostic factor in gastrointestinal stromal tumour.

Br J Cancer 2017 Apr 23;116(9):1195-1202. Epub 2017 Mar 23.

Laboratory of Molecular Oncology, Translational Cancer Biology Research Program, Department of Oncology, University of Helsinki, P.O Box 63, FI-00014 University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1038/bjc.2017.82DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5418455PMC
April 2017

Levonorgestrel-releasing intrauterine system and the risk of breast cancer: A nationwide cohort study.

Acta Oncol 2016 4;55(2):188-92. Epub 2015 Aug 4.

k School of Health Sciences, University of Tampere, University of Tampere , Finland.

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http://dx.doi.org/10.3109/0284186X.2015.1062538DOI Listing
January 2017

Escalating and de-escalating treatment in HER2-positive early breast cancer.

Authors:
Heikki Joensuu

Cancer Treat Rev 2017 Jan 10;52:1-11. Epub 2016 Nov 10.

Helsinki University Hospital and University of Helsinki, Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.ctrv.2016.11.002DOI Listing
January 2017

Leukocyte trafficking is not affected by multikinase inhibitors sunitinib or sorafenib in mice.

Int J Cancer 2016 11 11;139(10):2270-6. Epub 2016 Aug 11.

Medicity Research Laboratory and Department of Medical Microbiology and Immunology, University of Turku, Turku, Finland.

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http://dx.doi.org/10.1002/ijc.30285DOI Listing
November 2016

Adaptive Randomization of Neratinib in Early Breast Cancer.

Authors:
Heikki Joensuu

N Engl J Med 2016 10;375(16):1592

Helsinki University Hospital, Helsinki, Finland

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http://dx.doi.org/10.1056/NEJMc1609993DOI Listing
October 2016

Association of Angiopoietin-2 and Ki-67 Expression with Vascular Density and Sunitinib Response in Metastatic Renal Cell Carcinoma.

PLoS One 2016 21;11(4):e0153745. Epub 2016 Apr 21.

Translational Cancer Biology Program, Research Programs Unit, and Department of Virology, Haartman Institute, Biomedicum Helsinki, Haartmaninkatu 8, P.O.B. 63, FI-00014, University of Helsinki, Finland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0153745PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839598PMC
September 2016

Boron Neutron Capture Therapy in the Treatment of Recurrent Laryngeal Cancer.

Int J Radiat Oncol Biol Phys 2016 May 10;95(1):404-10. Epub 2015 Nov 10.

Department of Oncology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1016/j.ijrobp.2015.11.010DOI Listing
May 2016

[Triumphal march of cancer therapy goes on].

Authors:
Heikki Joensuu

Duodecim 2015 ;131(22):2163-70

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February 2016

Sunitinib-induced hypertension, neutropaenia and thrombocytopaenia as predictors of good prognosis in patients with metastatic renal cell carcinoma.

BJU Int 2016 Jan 2;117(1):110-7. Epub 2015 Jun 2.

Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1111/bju.12940DOI Listing
January 2016

Adjuvant Imatinib for High-Risk GI Stromal Tumor: Analysis of a Randomized Trial.

J Clin Oncol 2016 Jan 2;34(3):244-50. Epub 2015 Nov 2.

Heikki Joensuu and Petri Bono, Comprehensive Cancer Center Helsinki; Heikki Joensuu, Harri Sihto, and Petri Bono, University of Helsinki, Helsinki; Raija Kallio, Oulu University Hospital, Oulu; Jouni Junnila, 4Pharma, Turku, Finland; Mikael Eriksson and Thor Alvegård, Lund University, Lund; Bengt Nilsson, Sahlgrenska University Hospital, Gothenburg, Sweden; Kirsten Sundby Hall, Oslo University Hospital, Oslo, Norway; Annette Reichardt, Daniel Pink, and Peter Reichardt, Sarkomzentrum Berlin-Brandenburg, HELIOS Klinikum Berlin-Buch, Berlin; Jörg T. Hartmann, Franziskus Hospital, Catholic Hospital Consortium Ostwestfalen, Bielefeld; Giuliano Ramadori, University of Göttingen, Göttingen; Peter Hohenberger, Mannheim University Medical Center, Mannheim; Salah-Eddin Al-Batran, Klinik für Onkologie und Hämatologie am Krankenhaus Nordwest, Frankfurt; Marcus Schlemmer, University Hospital Großhadern, Ludwig Maximilians University, Munich; Sebastian Bauer, Sarcoma Center, West German Cancer Center, Essen; and Eva Wardelmann, Gerhard-Domagk-Institute of Pathology, University Hospital Münster, Münster, Germany.

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http://jco.ascopubs.org/content/early/2015/10/26/JCO.2015.62
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http://jco.ascopubs.org/cgi/doi/10.1200/JCO.2015.62.9170
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http://dx.doi.org/10.1200/JCO.2015.62.9170DOI Listing
January 2016

Improved Treatment of Breast Cancer with Anti-HER2 Therapy Requires Interleukin-21 Signaling in CD8+ T Cells.

Cancer Res 2016 Jan 7;76(2):264-74. Epub 2016 Jan 7.

Immunology in Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia. School of Medicine, University of Queensland, Herston, Queensland, Australia.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-1567DOI Listing
January 2016

Physician Estimations of the Risk of Gastrointestinal Stromal Tumor Recurrence--Not Accurate Enough?: More Education May Be Needed.

Authors:
Heikki Joensuu

JAMA Oncol 2015 Sep;1(6):805-6

Department of Oncology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1001/jamaoncol.2015.2404DOI Listing
September 2015

[Adjuvant drug therapies for breast cancer].

Duodecim 2015 ;131(1):23-8

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September 2015

Efficacy of Adjuvant Trastuzumab for Patients With Human Epidermal Growth Factor Receptor 2-Positive Early Breast Cancer and Tumors ≤ 2 cm: A Meta-Analysis of the Randomized Trastuzumab Trials.

J Clin Oncol 2015 Aug 22;33(24):2600-8. Epub 2015 Jun 22.

Ciara C. O'Sullivan and Jo Anne Zujewski, National Cancer Institute, Bethesda, MD; Ian Bradbury, Christine Campbell, and Eileen Holmes, Frontier Science, Inverness-shire, Scotland; Marc Spielmann and Suzette Delaloge, Institut de Cancérologie Gustave Roussy, Villejuif, France; Edith A. Perez, Mayo Clinic, Jacksonville, FL; Heikki Joensuu, Helsinki University Hospital and University of Helsinki, Helsinki, Finland; Joseph P. Costantino and Priya Rastogi, University of Pittsburgh, Pittsburgh, PA; Dimitrios Zardavas, Breast International Group; Karla V. Ballman, Mayo Clinic, Rochester, MN; Evandro de Azambuja and Martine Piccart-Gebhart, Institut Jules Bordet and L'Université Libre de Bruxelles, Brussels, Belgium; and Richard D. Gelber, Harvard Medical School, Harvard T.H. Chan School of Public Health, Dana-Farber Cancer Institute, and Frontier Science and Technology Research Foundation, Boston, MA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534523PMC
http://dx.doi.org/10.1200/JCO.2015.60.8620DOI Listing
August 2015

Emerging Agents for the Treatment of Advanced, Imatinib-Resistant Gastrointestinal Stromal Tumors: Current Status and Future Directions.

Drugs 2015 Aug;75(12):1323-34

Sarcoma Center, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, Essen, Germany.

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http://dx.doi.org/10.1007/s40265-015-0440-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532715PMC
August 2015

Radiotherapy for GIST progressing during or after tyrosine kinase inhibitor therapy: A prospective study.

Radiother Oncol 2015 Aug 27;116(2):233-8. Epub 2015 Jul 27.

Department of Oncology, University Hospital Lausanne, Switzerland.

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http://dx.doi.org/10.1016/j.radonc.2015.07.025DOI Listing
August 2015

Human breast cancer cells educate macrophages toward the M2 activation status.

Breast Cancer Res 2015 Aug 5;17:101. Epub 2015 Aug 5.

School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Yliopistonranta 1C, P.O. Box 1627, FI-70211, Kuopio, Finland.

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http://dx.doi.org/10.1186/s13058-015-0621-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531540PMC
August 2015

Key Issues in the Clinical Management of Gastrointestinal Stromal Tumors: An Expert Discussion.

Oncologist 2015 Jul 12;20(7):823-30. Epub 2015 Jun 12.

Tisch Cancer Institute, Mount Sinai Medical Center, New York, New York, USA; Department of Medical Oncology, Centre Léon Bérard, Lyon, France; Dana-Farber Cancer Institute, Boston, Massachusetts, USA; Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, USA; Helsinki University Hospital and University of Helsinki, Helsinki, Finland; Servicio de Oncología Médica, Fundación Instituto Valenciano de Oncología, Valencia, Spain; National Cancer Center Hospital East, Department of Surgery, Kashiwa, Japan; HELIOS Klinikum Berlin-Buch, Interdisciplinary Oncology, Berlin, Germany; General Medical Oncology, Leuven Cancer Institute, University Hospital Gasthuisberg, Catholic University Leuven, Leuven, Belgium; University of Miami Sylvester Cancer Center, Sarcoma Medical Oncology Program, Miami, Florida, USA.

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http://dx.doi.org/10.1634/theoncologist.2014-0471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492234PMC
July 2015

Cancer in young adults with ischemic stroke.

Stroke 2015 Jun 28;46(6):1601-6. Epub 2015 Apr 28.

From the Clinical Neurosciences, Department of Neurology, University of Helsinki and Helsinki University Central Hospital, Finland (K.A., E.H., S.M., M.K., T.T., J.P.); Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland (H.J.); and Institute of Neurosciences and Physiology, Sahlgrenska Academy, University of Gothenburg and Department of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden (T.T.).

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http://dx.doi.org/10.1161/STROKEAHA.115.008694DOI Listing
June 2015

Development and validation of prognostic nomograms for metastatic gastrointestinal stromal tumour treated with imatinib.

Eur J Cancer 2015 May 19;51(7):852-60. Epub 2015 Mar 19.

Department of Soft Tissue/Bone Sarcoma and Melanoma, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2015.02.015DOI Listing
May 2015

Elevated levels of StAR-related lipid transfer protein 3 alter cholesterol balance and adhesiveness of breast cancer cells: potential mechanisms contributing to progression of HER2-positive breast cancers.

Am J Pathol 2015 Apr 12;185(4):987-1000. Epub 2015 Feb 12.

Faculty of Medicine, Department of Anatomy, University of Helsinki, Helsinki, Finland; Minerva Foundation Institute for Medical Research, Biomedicum 2U, Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2014.12.018DOI Listing
April 2015

ERBB4 promoter polymorphism is associated with poor distant disease-free survival in high-risk early breast cancer.

PLoS One 2014 18;9(7):e102388. Epub 2014 Jul 18.

Department of Medical Biochemistry and Genetics and Medicity Research Laboratories, University of Turku, Turku, Finland; Department of Oncology, Turku University Hospital, Turku, Finland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0102388PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103820PMC
March 2015

KIT and PDGFRA mutations and the risk of GI stromal tumor recurrence.

J Clin Oncol 2015 Feb 20;33(6):634-42. Epub 2015 Jan 20.

Heikki Joensuu, Helsinki University Central Hospital, Helsinki, Finland; Piotr Rutkowski, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland; Toshirou Nishida, National Cancer Center Hospital East, Kashiwa, Japan; Sonja E. Steigen, University Hospital of North Norway and Tumor Biology Research Group, UiT The Arctic University of Norway, Tromsø, Norway; Peter Brabec, Institute of Biostatistics and Analyses, Masaryk University, Brno, Czech Republic; Lukas Plank, Jessenius Medical Faculty of Comenius University and University Hospital, Martin; Jozef Sufliarsky, National Cancer Institute, Bratislava, Slovak Republic; Bengt Nilsson, Sahlgrenska University Hospital, Gothenburg, Sweden; Chiara Braconi, Centro Regionale di Genetica Oncologica, Oncologia Medica, Ancona; Massimo Federico, University of Modena and Reggio Emilia, Modena, Italy; Chiara Braconi, The Institute of Cancer Research, Belmont, United Kingdom; Andrea Bordoni, Ticino Cancer Registry, Insitute of Pathology South of Switzerland, Locarno, Switzerland; Magnus K. Magnusson, University of Iceland; Jon G. Jonasson, Landspitali-The National University Hospital of Iceland, Reykjavik, Iceland; Isabelle Hostein, Bergonié Institute, Bordeaux; Pierre-Paul Bringier, E. Herriot Hospital, Lyon; Jean-Francois Emile, Versailles University and Assistance Publique-Hôpitaux de Paris, Ambroise Paré Hospital, Boulogne, France.

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http://dx.doi.org/10.1200/JCO.2014.57.4970DOI Listing
February 2015

Dual targeting of HER2 with lapatinib and trastuzumab.

Authors:
Heikki Joensuu

Lancet Oncol 2014 Sep 14;15(10):1050-2. Epub 2014 Aug 14.

Department of Oncology, Helsinki University Central Hospital & University of Helsinki, Haartmaninkatu 4, FIN-00029 Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/S1470-2045(14)70342-0DOI Listing
September 2014

Gastrointestinal stromal tumor: a method for optimizing the timing of CT scans in the follow-up of cancer patients.

Radiology 2014 Apr 18;271(1):96-103. Epub 2013 Nov 18.

From the Department of Oncology, Helsinki University Central Hospital, Haartmaninkatu 4, PO Box 180, FIN-00029 Helsinki, Finland (H.J.); Sarkomzentrum Berlin-Brandenburg, HELIOS Klinikum Berlin-Buch, Berlin, Germany (P.R.); Department of Oncology, Skåne University Hospital, Lund University, Lund, Sweden (M.E.); Department of Oncology, the Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway (K.S.H.); and Department of Biomedical Engineering and Computational Science, Aalto University, Espoo, Finland (A.V.).

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http://dx.doi.org/10.1148/radiol.13131040DOI Listing
April 2014

Novel target for peptide-based imaging and treatment of brain tumors.

Mol Cancer Ther 2014 Apr 3;13(4):996-1007. Epub 2014 Feb 3.

Authors' Affiliations: Research Programs Unit, Translational Cancer Biology and Institute of Biomedicine and Laboratory of Molecular Oncology, Biomedicum Helsinki, University of Helsinki; Department of Oncology, Helsinki University Central Hospital; Finnish Cancer Institute, Helsinki; A.I. Virtanen Institute for Molecular Medicine, University of Eastern Finland, Kuopio, Finland; Department of Neurochemistry, Stockholm University, Stockholm, Sweden; and UCSF Helen Diller Family Cancer Center, San Francisco, California.

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http://dx.doi.org/10.1158/1535-7163.MCT-13-0684DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007056PMC
April 2014

Pazopanib after sunitinib failure in patients with metastatic renal cell carcinoma.

Acta Oncol 2014 Jan 30;53(1):113-8. Epub 2013 May 30.

Department of Oncology, Helsinki University Central Hospital , Helsinki , Finland.

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http://dx.doi.org/10.3109/0284186X.2013.794957DOI Listing
January 2014

Management of small gastrointestinal stromal tumours - Authors' reply.

Lancet 2013 Nov;382(9906):1701-2

Department of Oncology, Helsinki University Central Hospital, 00029 Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/S0140-6736(13)62398-3DOI Listing
November 2013

New fronts in the adjuvant treatment of GIST.

Cancer Chemother Pharmacol 2013 Oct 11;72(4):715-23. Epub 2013 Aug 11.

Department of Hematology, Oncology and Palliative Medicine, HELIOS Klinikum Bad Saarow, Pieskower Strasse 33, 15526, Bad Saarow, Germany,

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http://link.springer.com/content/pdf/10.1007/s00280-013-2248
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http://link.springer.com/10.1007/s00280-013-2248-0
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http://dx.doi.org/10.1007/s00280-013-2248-0DOI Listing
October 2013

Gastrointestinal stromal tumors: risk assessment and adjuvant therapy.

Authors:
Heikki Joensuu

Hematol Oncol Clin North Am 2013 Oct 2;27(5):889-904. Epub 2013 Aug 2.

Department of Oncology, Helsinki University Central Hospital, Helsinki University, Haartmaninkatu 4, Helsinki FIN-00029, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.hoc.2013.07.004DOI Listing
October 2013

A patient-centered methodology that improves the accuracy of prognostic predictions in cancer.

PLoS One 2013 27;8(2):e56435. Epub 2013 Feb 27.

Center for Melanoma Research and Treatment, California Pacific Medical Center and Research Institute, San Francisco, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0056435PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584071PMC
September 2013

Gastrointestinal stromal tumour.

Lancet 2013 Sep 24;382(9896):973-83. Epub 2013 Apr 24.

Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1016/S0140-6736(13)60106-3DOI Listing
September 2013

Duration of adjuvant trastuzumab: shorter beats longer.

Authors:
Heikki Joensuu

Lancet 2013 Sep 18;382(9897):1010-1. Epub 2013 Jul 18.

Department of Oncology, Helsinki University Central Hospital and Helsinki University, Haartmaninkatu 4, FIN-00029 Helsinki, Finland.

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http://dx.doi.org/10.1016/S0140-6736(13)61448-8DOI Listing
September 2013

Stomach cancer risk after treatment for hodgkin lymphoma.

J Clin Oncol 2013 Sep 26;31(27):3369-77. Epub 2013 Aug 26.

Lindsay M. Morton, Graça M. Dores, Rochelle E. Curtis, Ethel S. Gilbert, Ruth A. Kleinerman, and Joseph F. Fraumeni Jr, National Cancer Institute, Bethesda, MD; Graça M. Dores, Department of Veterans Affairs Medical Center, Oklahoma City, OK; Charles F. Lynch, University of Iowa, Iowa City, IA; Marilyn Stovall, Susan A. Smith, and Rita E. Weathers, University of Texas MD Anderson Cancer Center, Houston, TX; Per Hall and Magnus Kaijser, Karolinska Institute, Stockholm, Sweden; David C. Hodgson and Eric J. Holowaty, University of Toronto, Toronto, Ontario, Canada; Hans H. Storm, Danish Cancer Society; Michael Andersson, Copenhagen University Hospital, Copenhagen, Denmark; Tom Børge Johannesen and Frøydis Langmark, Cancer Registry of Norway; Sophie D. Fossa, Oslo University Hospital and University of Oslo, Oslo, Norway; Michael Hauptmann, Alexandra W. Van den Belt-Dusebout, Berthe M. Aleman, and Flora E. van Leeuwen, Netherlands Cancer Institute, Amsterdam, the Netherlands; Heikki Joensuu and Leila Vaalavirta, Helsinki University Central Hospital; Eero Pukkala, Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Helsinki, Finland; Lois B. Travis, University of Rochester Medical Center, Rochester, NY.

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http://dx.doi.org/10.1200/JCO.2013.50.6832DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770865PMC
September 2013

Radiation dose and subsequent risk for stomach cancer in long-term survivors of cervical cancer.

Int J Radiat Oncol Biol Phys 2013 Aug 22;86(5):922-9. Epub 2013 May 22.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Rockville, Maryland, USA.

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http://dx.doi.org/10.1016/j.ijrobp.2013.04.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3831516PMC
August 2013

Somatic mutation profiling and associations with prognosis and trastuzumab benefit in early breast cancer.

J Natl Cancer Inst 2013 Jul 5;105(13):960-7. Epub 2013 Jun 5.

Breast Cancer Translational Research Laboratory, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium.

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http://dx.doi.org/10.1093/jnci/djt121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3699437PMC
July 2013

Proteolytic processing of ErbB4 in breast cancer.

PLoS One 2012 22;7(6):e39413. Epub 2012 Jun 22.

Medicity Research Laboratories, Department of Medical Biochemistry and Genetics, University of Turku, Turku, Finland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0039413PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382207PMC
March 2013

Local recurrence of breast cancer after mastectomy and modern multidisciplinary treatment.

Acta Oncol 2013 Jan 13;52(1):66-72. Epub 2012 Sep 13.

Breast Surgery Unit, Helsinki University Central Hospital, Helsinki, Finland.

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http://www.tandfonline.com/doi/full/10.3109/0284186X.2012.71
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http://dx.doi.org/10.3109/0284186X.2012.718793DOI Listing
January 2013

[Tyrosine kinases as targets of cancer therapy: from disbelief to Lazarus responses].

Authors:
Heikki Joensuu

Duodecim 2012 ;128(21):2261-8

HYKS, syöpätautien klinikka.

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January 2013

Tumor-infiltrating lymphocytes and outcome in Merkel cell carcinoma, a virus-associated cancer.

Oncoimmunology 2012 Nov;1(8):1420-1421

Laboratory of Molecular Oncology and Molecular Cancer Biology Program; University of Helsinki; Helsinki, Finland.

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http://dx.doi.org/10.4161/onci.21120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518523PMC
November 2012

Adjuvant therapy for high-risk gastrointestinal stromal tumour: considerations for optimal management.

Authors:
Heikki Joensuu

Drugs 2012 Oct;72(15):1953-63

Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland.

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http://dx.doi.org/10.2165/11635590-000000000-00000DOI Listing
October 2012

Adjuvant treatment of GIST: patient selection and treatment strategies.

Authors:
Heikki Joensuu

Nat Rev Clin Oncol 2012 Apr 24;9(6):351-8. Epub 2012 Apr 24.

Department of Oncology, Helsinki University Central Hospital, Haartmaninkatu 4, POB 180, FIN-00029 Helsinki, Finland.

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http://dx.doi.org/10.1038/nrclinonc.2012.74DOI Listing
April 2012