Publications by authors named "Hasem Habelhah"

23Publications

TRAF2 Ser-11 Phosphorylation Promotes Cytosolic Translocation of the CD40 Complex To Regulate Downstream Signaling Pathways.

Authors:
Lauren M Workman Laiqun Zhang Yumei Fan Weizhou Zhang Hasem Habelhah

Mol Cell Biol 2020 04 13;40(9). Epub 2020 Apr 13.

Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA

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April 2020

Deferasirox protects against hydrogen peroxide-induced cell apoptosis by inhibiting ubiquitination and degradation of p21.

Authors:
Junhua Miao Mutao Xu Yuhuan Kuang Shuhong Pan Jianyuan Hou Pengxiu Cao Xianglin Duan Yanzhong Chang Habelhah Hasem Nan Zhou Ke Tan Yumei Fan

Biochem Biophys Res Commun 2020 04 5;524(3):736-743. Epub 2020 Feb 5.

Laboratory of Molecular Iron Metabolism, Key Laboratory of Animal Physiology, Biochemistry and Molecular Biology of Hebei Province, Key Laboratory of Molecular and Cellular Biology of Ministry of Education, College of Life Science, Hebei Normal University, Shijiazhuang, 050024, PR China; Department of Pathology, Carver College of Medicine, The University of Iowa, Iowa City, IA, 52242, United States. Electronic address:

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April 2020

Coactivation of NF-κB and Notch signaling is sufficient to induce B-cell transformation and enables B-myeloid conversion.

Authors:
Yan Xiu Qianze Dong Lin Fu Aaron Bossler Xiaobing Tang Brendan Boyce Nicholas Borcherding Mariah Leidinger José Luis Sardina Hai-Hui Xue Qingchang Li Andrew Feldman Iannis Aifantis Francesco Boccalatte Lili Wang Meiling Jin Joseph Khoury Wei Wang Shimin Hu Youzhong Yuan Endi Wang Ji Yuan Siegfried Janz John Colgan Hasem Habelhah Thomas Waldschmidt Markus Müschen Adam Bagg Benjamin Darbro Chen Zhao

Blood 2020 01;135(2):108-120

Department of Pathology, Carver College of Medicine, University of Iowa, Iowa City, IA.

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January 2020

Destabilizing NEK2 overcomes resistance to proteasome inhibition in multiple myeloma.

Authors:
Reinaldo Franqui-Machin Mu Hao Hua Bai Zhimin Gu Xin Zhan Hasem Habelhah Yogesh Jethava Lugui Qiu Ivana Frech Guido Tricot Fenghuang Zhan

J Clin Invest 2018 07 4;128(7):2877-2893. Epub 2018 Jun 4.

Molecular Medicine Program and.

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July 2018

TRAF2 exerts opposing effects on basal and TNFα-induced activation of the classic IKK complex in hematopoietic cells in mice.

Authors:
Laiqun Zhang Ken Blackwell Lauren M Workman Katherine N Gibson-Corley Alicia K Olivier Gail A Bishop Hasem Habelhah

J Cell Sci 2016 Apr 12;129(7):1455-67. Epub 2016 Feb 12.

Department of Pathology, Carver College of Medicine, University of Iowa, and the Iowa City Veterans Affairs Medical Center, Iowa City, IA 52242, USA

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April 2016

RIP1 Cleavage in the Kinase Domain Regulates TRAIL-Induced NF-κB Activation and Lymphoma Survival.

Authors:
Laiqun Zhang Ken Blackwell Lauren M Workman Songhai Chen Marshall R Pope Siegfried Janz Hasem Habelhah

Mol Cell Biol 2015 Oct 20;35(19):3324-38. Epub 2015 Jul 20.

Department of Pathology, Carver College of Medicine, The University of Iowa, Iowa City, Iowa, USA

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October 2015

TRAIL activates JNK and NF-κB through RIP1-dependent and -independent pathways.

Authors:
Laiqun Zhang Martin R Dittmer Ken Blackwell Lauren M Workman Bruce Hostager Hasem Habelhah

Cell Signal 2015 Feb 18;27(2):306-14. Epub 2014 Nov 18.

Department of Pathology, Carver College of Medicine, the University of Iowa, Iowa City, IA 52242, United States. Electronic address:

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February 2015

The PP4R1 subunit of protein phosphatase PP4 targets TRAF2 and TRAF6 to mediate inhibition of NF-κB activation.

Authors:
Paul Hadweh Hasem Habelhah Elliott Kieff George Mosialos Eudoxia Hatzivassiliou

Cell Signal 2014 Dec 16;26(12):2730-7. Epub 2014 Aug 16.

Laboratory of Biological Chemistry, Medical School, Aristotle University of Thessaloniki, 54124 Thessaloniki, Macedonia, Greece. Electronic address:

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December 2014

Fascin regulates chronic inflammation-related human colon carcinogenesis by inhibiting cell anoikis.

Authors:
Yusuke Kanda Tokuichi Kawaguchi Yasuhiro Kuramitsu Takao Kitagawa Tokushige Kobayashi Norihiko Takahashi Hiroshi Tazawa Hasem Habelhah Jun-Ichi Hamada Masanobu Kobayashi Mio Hirahata Kunishige Onuma Mitsuhiko Osaki Kazuyuki Nakamura Tomoyuki Kitagawa Masuo Hosokawa Futoshi Okada

Proteomics 2014 May 25;14(9):1031-41. Epub 2014 Mar 25.

Division of Pathological Biochemistry, Tottori University Faculty of Medicine, Yonago, Japan.

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May 2014

TNFR1 signaling kinetics: spatiotemporal control of three phases of IKK activation by posttranslational modification.

Authors:
Lauren M Workman Hasem Habelhah

Cell Signal 2013 Aug 21;25(8):1654-64. Epub 2013 Apr 21.

Interdisciplinary Graduate Program in Molecular and Cellular Biology, University of Iowa, Iowa City, IA 52242, USA.

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August 2013

Two coordinated mechanisms underlie tumor necrosis factor alpha-induced immediate and delayed IκB kinase activation.

Authors:
Ken Blackwell Laiqun Zhang Lauren M Workman Adrian T Ting Kazuhiro Iwai Hasem Habelhah

Mol Cell Biol 2013 May 4;33(10):1901-15. Epub 2013 Mar 4.

Department of Pathology, Carver College of Medicine, USA.

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May 2013

IκB kinase ε phosphorylates TRAF2 to promote mammary epithelial cell transformation.

Authors:
Rhine R Shen Alicia Y Zhou Eejung Kim Elgene Lim Hasem Habelhah William C Hahn

Mol Cell Biol 2012 Dec 24;32(23):4756-68. Epub 2012 Sep 24.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

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December 2012

TRAF2 phosphorylation promotes NF-κB-dependent gene expression and inhibits oxidative stress-induced cell death.

Authors:
Laiqun Zhang Ken Blackwell Aliya Altaeva Zhaohui Shi Hasem Habelhah

Mol Biol Cell 2011 Jan 30;22(1):128-40. Epub 2010 Nov 30.

Department of Pathology, Carver College of Medicine, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA.

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January 2011

Emerging complexity of protein ubiquitination in the NF-κB pathway.

Authors:
Hasem Habelhah

Genes Cancer 2010 Jul;1(7):735-747

Department of Pathology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242.

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July 2010

The RING domain of TRAF2 plays an essential role in the inhibition of TNFalpha-induced cell death but not in the activation of NF-kappaB.

Authors:
Laiqun Zhang Ken Blackwell Zhaohui Shi Hasem Habelhah

J Mol Biol 2010 Feb 11;396(3):528-39. Epub 2010 Jan 11.

Department of Pathology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.

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February 2010

TRAF2 suppresses basal IKK activity in resting cells and TNFalpha can activate IKK in TRAF2 and TRAF5 double knockout cells.

Authors:
Laiqun Zhang Ken Blackwell Gregory S Thomas Shujie Sun Wen-Chen Yeh Hasem Habelhah

J Mol Biol 2009 Jun 3;389(3):495-510. Epub 2009 May 3.

Department of Pathology, Carver College of Medicine, University of Iowa, 200 Hawkins Drive, 1173ML, Iowa City, IA 52242-1087, USA.

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June 2009

Phosphorylation of TRAF2 within its RING domain inhibits stress-induced cell death by promoting IKK and suppressing JNK activation.

Authors:
Gregory S Thomas Laiqun Zhang Ken Blackwell Hasem Habelhah

Cancer Res 2009 Apr 31;69(8):3665-72. Epub 2009 Mar 31.

Pathology Graduate Program and Department of Pathology, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA.

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April 2009

TRAF2 phosphorylation modulates tumor necrosis factor alpha-induced gene expression and cell resistance to apoptosis.

Authors:
Ken Blackwell Laiqun Zhang Gregory S Thomas Shujie Sun Hiroyasu Nakano Hasem Habelhah

Mol Cell Biol 2009 Jan 3;29(2):303-14. Epub 2008 Nov 3.

Department of Pathology, Carver College of Medicine, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA.

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January 2009

RACK1 mediates activation of JNK by protein kinase C [corrected].

Authors:
Pablo López-Bergami Hasem Habelhah Anindita Bhoumik Weizhou Zhang Lu-Hai Wang Ze'ev Ronai

Mol Cell 2005 Aug;19(3):309-20

Department of Oncological Sciences, Mount Sinai School of Medicine, New York, New York 10029, USA.

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August 2005

Regulation of 2-oxoglutarate (alpha-ketoglutarate) dehydrogenase stability by the RING finger ubiquitin ligase Siah.

Authors:
Hasem Habelhah Aaron Laine Hediye Erdjument-Bromage Paul Tempst M Eric Gershwin David D L Bowtell Ze'ev Ronai

J Biol Chem 2004 Dec 5;279(51):53782-8. Epub 2004 Oct 5.

Department of Oncological Sciences, Mount Sinai School of Medicine, 1 Gustave L. Levy Place, New York, NY 10029, USA.

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December 2004