Publications by authors named "Hasem Habelhah"

23Publications

TRAF2 Ser-11 Phosphorylation Promotes Cytosolic Translocation of the CD40 Complex To Regulate Downstream Signaling Pathways.

Mol Cell Biol 2020 04 13;40(9). Epub 2020 Apr 13.

Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA

View Article and Find Full Text PDF
April 2020

Deferasirox protects against hydrogen peroxide-induced cell apoptosis by inhibiting ubiquitination and degradation of p21.

Biochem Biophys Res Commun 2020 04 5;524(3):736-743. Epub 2020 Feb 5.

Laboratory of Molecular Iron Metabolism, Key Laboratory of Animal Physiology, Biochemistry and Molecular Biology of Hebei Province, Key Laboratory of Molecular and Cellular Biology of Ministry of Education, College of Life Science, Hebei Normal University, Shijiazhuang, 050024, PR China; Department of Pathology, Carver College of Medicine, The University of Iowa, Iowa City, IA, 52242, United States. Electronic address:

View Article and Find Full Text PDF
April 2020

TRAF2 exerts opposing effects on basal and TNFα-induced activation of the classic IKK complex in hematopoietic cells in mice.

J Cell Sci 2016 Apr 12;129(7):1455-67. Epub 2016 Feb 12.

Department of Pathology, Carver College of Medicine, University of Iowa, and the Iowa City Veterans Affairs Medical Center, Iowa City, IA 52242, USA

View Article and Find Full Text PDF
April 2016

RIP1 Cleavage in the Kinase Domain Regulates TRAIL-Induced NF-κB Activation and Lymphoma Survival.

Mol Cell Biol 2015 Oct 20;35(19):3324-38. Epub 2015 Jul 20.

Department of Pathology, Carver College of Medicine, The University of Iowa, Iowa City, Iowa, USA

View Article and Find Full Text PDF
October 2015

TRAIL activates JNK and NF-κB through RIP1-dependent and -independent pathways.

Cell Signal 2015 Feb 18;27(2):306-14. Epub 2014 Nov 18.

Department of Pathology, Carver College of Medicine, the University of Iowa, Iowa City, IA 52242, United States. Electronic address:

View Article and Find Full Text PDF
February 2015

The PP4R1 subunit of protein phosphatase PP4 targets TRAF2 and TRAF6 to mediate inhibition of NF-κB activation.

Cell Signal 2014 Dec 16;26(12):2730-7. Epub 2014 Aug 16.

Laboratory of Biological Chemistry, Medical School, Aristotle University of Thessaloniki, 54124 Thessaloniki, Macedonia, Greece. Electronic address:

View Article and Find Full Text PDF
December 2014

TNFR1 signaling kinetics: spatiotemporal control of three phases of IKK activation by posttranslational modification.

Cell Signal 2013 Aug 21;25(8):1654-64. Epub 2013 Apr 21.

Interdisciplinary Graduate Program in Molecular and Cellular Biology, University of Iowa, Iowa City, IA 52242, USA.

View Article and Find Full Text PDF
August 2013

IκB kinase ε phosphorylates TRAF2 to promote mammary epithelial cell transformation.

Mol Cell Biol 2012 Dec 24;32(23):4756-68. Epub 2012 Sep 24.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

View Article and Find Full Text PDF
December 2012

TRAF2 phosphorylation promotes NF-κB-dependent gene expression and inhibits oxidative stress-induced cell death.

Mol Biol Cell 2011 Jan 30;22(1):128-40. Epub 2010 Nov 30.

Department of Pathology, Carver College of Medicine, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA.

View Article and Find Full Text PDF
January 2011

Emerging complexity of protein ubiquitination in the NF-κB pathway.

Authors:
Hasem Habelhah

Genes Cancer 2010 Jul;1(7):735-747

Department of Pathology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242.

View Article and Find Full Text PDF
July 2010

The RING domain of TRAF2 plays an essential role in the inhibition of TNFalpha-induced cell death but not in the activation of NF-kappaB.

J Mol Biol 2010 Feb 11;396(3):528-39. Epub 2010 Jan 11.

Department of Pathology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.

View Article and Find Full Text PDF
February 2010

TRAF2 suppresses basal IKK activity in resting cells and TNFalpha can activate IKK in TRAF2 and TRAF5 double knockout cells.

J Mol Biol 2009 Jun 3;389(3):495-510. Epub 2009 May 3.

Department of Pathology, Carver College of Medicine, University of Iowa, 200 Hawkins Drive, 1173ML, Iowa City, IA 52242-1087, USA.

View Article and Find Full Text PDF
June 2009

Phosphorylation of TRAF2 within its RING domain inhibits stress-induced cell death by promoting IKK and suppressing JNK activation.

Cancer Res 2009 Apr 31;69(8):3665-72. Epub 2009 Mar 31.

Pathology Graduate Program and Department of Pathology, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA.

View Article and Find Full Text PDF
April 2009

TRAF2 phosphorylation modulates tumor necrosis factor alpha-induced gene expression and cell resistance to apoptosis.

Mol Cell Biol 2009 Jan 3;29(2):303-14. Epub 2008 Nov 3.

Department of Pathology, Carver College of Medicine, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA.

View Article and Find Full Text PDF
January 2009

RACK1 mediates activation of JNK by protein kinase C [corrected].

Mol Cell 2005 Aug;19(3):309-20

Department of Oncological Sciences, Mount Sinai School of Medicine, New York, New York 10029, USA.

View Article and Find Full Text PDF
August 2005

Regulation of 2-oxoglutarate (alpha-ketoglutarate) dehydrogenase stability by the RING finger ubiquitin ligase Siah.

J Biol Chem 2004 Dec 5;279(51):53782-8. Epub 2004 Oct 5.

Department of Oncological Sciences, Mount Sinai School of Medicine, 1 Gustave L. Levy Place, New York, NY 10029, USA.

View Article and Find Full Text PDF
December 2004