Publications by authors named "Hao Chen"

4,269 Publications

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Potassium Sodium Niobate-Based Lead-Free High-Frequency Ultrasonic Transducers for Multifunctional Acoustic Tweezers.

ACS Appl Mater Interfaces 2022 Jun 29. Epub 2022 Jun 29.

College of Materials Science and Engineering, Sichuan University, Chengdu 610064 , China.

Ultrasonic transducers may need to operate in direct contact with the human body, especially with the skin or closer to blood vessels. Eco-friendly lead-free materials and devices are therefore being vigorously developed for biosafety considerations. This work presents high-performance potassium sodium niobate [(K,Na)NbO, KNN]-based lead-free ceramics with composition-driven multiphase coexistence and their application on high-frequency ultrasonic transducers for multifunctional acoustic tweezers. A high piezoelectric constant value of 332 pC/N, a good Curie temperature value of 348 °C, and improved in situ temperature stability were obtained in the piezoceramics via the construction multiple phases near room temperature and domain engineering. One to three piezocomposites were further fabricated based on the synthesized ceramics for higher electromechanical coupling properties. Lead-free high-frequency transducers as multifunctional acoustic tweezers for precise and selective manipulation of microparticles were designed and manufactured with a high center frequency of 23.4 MHz and a broad -6 dB bandwidth of 75.4%. Additionally, a stable transducer performance was obtained over a test temperature range of 23-60 °C, indicating good thermal stability in environments with fluctuating temperatures. Research on lead-free high-frequency transducers for ultrasound imaging and precise and selective manipulation of microparticles demonstrates their broad potential in fields such as medical therapy and diagnosis.
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http://dx.doi.org/10.1021/acsami.2c05687DOI Listing
June 2022

Time-frequency connectedness between energy and nonenergy commodity markets during COVID-19: Evidence from China.

Resour Policy 2022 Jun 24:102874. Epub 2022 Jun 24.

School of Finance, Hubei University of Economics, Wuhan, 430205, China.

We aim to investigate the static and dynamic time-frequency connectedness between energy and nonenergy commodity markets in China during COVID-19 based on Baruník and Křehlík (2018) method. First, in this paper, we find that the short-term connectedness dominates the long-term one, and the total connectedness increases after the COVID-19 outbreak. Second, the energy commodity is the receiver and is influenced much by the spillovers of non-energy commodity markets (e.g. chemical commodities and non-ferrous metals) in the short run. At the same time, the impact is less at the long-term investment horizons. In addition, chemical commodities and soft commodities are the primary transmitters in this system in the short run. In contrast, chemical commodities and coal steel iron commodities are the main long-run primary transmitters. Third, the spillover role varies with the time-frequency domain during COVID-19. To be more specific, the energy commodity shows a net receiver role in the short and long run before the COVID-19 pandemic, but after it, the role of the net transmitter can be seen in the long run with ease. Finally, we show that COVID can reduce the hedging effectiveness at different investment horizons. The mineral policymakers should note our dynamic empirical results between energy and nonenergy commodity.
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http://dx.doi.org/10.1016/j.resourpol.2022.102874DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9226294PMC
June 2022

Dielectric metalens for miniaturized imaging systems: progress and challenges.

Light Sci Appl 2022 Jun 28;11(1):195. Epub 2022 Jun 28.

College of Mechanical and Vehicle Engineering, Hunan University, Changsha, 410082, China.

Lightweight, miniaturized optical imaging systems are vastly anticipated in these fields of aerospace exploration, industrial vision, consumer electronics, and medical imaging. However, conventional optical techniques are intricate to downscale as refractive lenses mostly rely on phase accumulation. Metalens, composed of subwavelength nanostructures that locally control light waves, offers a disruptive path for small-scale imaging systems. Recent advances in the design and nanofabrication of dielectric metalenses have led to some high-performance practical optical systems. This review outlines the exciting developments in the aforementioned area whilst highlighting the challenges of using dielectric metalenses to replace conventional optics in miniature optical systems. After a brief introduction to the fundamental physics of dielectric metalenses, the progress and challenges in terms of the typical performances are introduced. The supplementary discussion on the common challenges hindering further development is also presented, including the limitations of the conventional design methods, difficulties in scaling up, and device integration. Furthermore, the potential approaches to address the existing challenges are also deliberated.
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http://dx.doi.org/10.1038/s41377-022-00885-7DOI Listing
June 2022

Chitosan-based composite microspheres for treatment of hexavalent chromium and EBBR from aqueous solution.

Chemosphere 2022 Jun 25:135486. Epub 2022 Jun 25.

School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang, Jiangsu, 212013, China. Electronic address:

Hexavalent chromium is widely used in industrial fields, but its pollution has posed a great threat to the environment due to its high toxicity. We created a chitosan-based microsphere biosorbent (CP) by combining polyethyleneimine with chitosan adopting inverse emulsion polymerization method. Under the optimal conditions (pH = 3), the maximum adsorption capacity of composite microspheres can reach 299.89 mg g, which is much higher than that of chitosan microspheres (168.91 mg g). When the amount of CP is 0.25 g L, the removal rate of 50 mg L Cr(VI) and 50 mg L Eriochrome blue-black R (EBBR) can reach 95% and 99%, respectively. The time required for CP to reach adsorption equilibrium (180 min) was significantly shorter than that of chitosan microspheres (540 min), and the adsorption rate was significantly improved. Langmuir isotherm model, pseudo-second-order kinetic model and thermodynamic calculation results penetrated an endothermic spontaneous, monolayer, and chemical adsorption process. Biomass composite microspheres CP has obvious selectivity and the adsorption capacity retention rate of CP was still 71.32% after four adsorption cycles. This work proposed an easily prepared and biomass-based microspheres for the effective removal of Cr(VI) in printing and dyeing wastewater pollution through adsorption.
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http://dx.doi.org/10.1016/j.chemosphere.2022.135486DOI Listing
June 2022

Tissue factor: a neglected role in cancer biology.

J Thromb Thrombolysis 2022 Jun 28. Epub 2022 Jun 28.

The Department of Tumor Surgery, Lanzhou University Second Hospital, Lanzhou, China.

Tissue factor (TF), an initiator of extrinsic coagulation pathway, is positively correlated with venous thromboembolism (VTE) of tumor patients. Beyond thrombosis, TF plays a vital role in tumor progression. TF is highly expressed in cancer tissues and circulating tumor cell (CTC), and activates factor VIIa (FVIIa), which increases tumor cells proliferation, angiogenesis, epithelial-mesenchymal transition (EMT) and cancer stem cells(CSCs) activity. Furthermore, TF and TF-positive microvesicles (TFMVs) activate the coagulation system to promote the clots formation with non-tumor cell components (e.g., platelets, leukocytes, fibrin), which makes tumor cells adhere to clots to form CTC clusters. Then, tumor cells utilize clots to cause its reducing fluid shear stress (FSS), anoikis resistance, immune escape, adhesion, extravasation and colonization. Herein, we review in detail that how TF signaling promotes tumor metastasis, and how TF-targeted therapeutic strategies are being in the preclinical and clinical trials.
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http://dx.doi.org/10.1007/s11239-022-02662-0DOI Listing
June 2022

Cold-Starting All-Solid-State Batteries from Room Temperature by Thermally Modulated Current Collector in Sub-Minute.

Adv Mater 2022 Jun 27:e2202848. Epub 2022 Jun 27.

Department of Materials Science and Engineering, Stanford University, Stanford, CA, 94305, USA.

All-solid-state batteries (ASSBs) show great potential as high-energy and high-power energy storage devices but their attainable energy/power density at room temperature is severely reduced because of the sluggish kinetics of lithium-ion transport. Here we first reported a thermally modulated current collector (TMCC), which can rapidly cold-start ASSBs from room temperature to operating temperatures (70∼90 °C) in less than one minute, and simultaneously enhance the transient peak power density by 15-fold compared to one without heating. This TMCC is prepared by integrating a uniform, ultrathin (∼200 nm) nickel layer as a thermal modulator within an ultralight polymer-based current collector. By isolating the thermal modulator from the ion/electron pathway of ASSBs, it can provide fast, stable heat control yet does not interfere with regular battery operation. Moreover, this ultrathin (13.2 μm) TMCC effectively shortens the heat transfer pathway, minimizes heat losses, and mitigates the formation of local hot spots. The simulated heating energy consumption can be as low as ∼3.94% of total battery energy. This TMCC design with good tunability opens new frontiers towards smart energy storage devices in the future from the current collector perspective. This article is protected by copyright. All rights reserved.
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http://dx.doi.org/10.1002/adma.202202848DOI Listing
June 2022

Fixed bed column performance of Al-modified biochar for the removal of sulfamethoxazole and sulfapyridine antibiotics from wastewater.

Chemosphere 2022 Jun 24:135475. Epub 2022 Jun 24.

Department of Agricultural and Biological Engineering, University of Florida, Gainesville, FL, 32611, USA. Electronic address:

In this study, biochar derived from bamboo pretreated with aluminum salt was synthesized for the removal of two sulfonamide antibiotics, sulfamethoxazole (SMX) and sulfapyridine (SPY), from wastewater. Batch sorption experiments showed that Al-modified bamboo biochar (Al-BB-600) removed both sulfonamides effectively with the maximum sorption capacity of 1200-2200 mg/kg. The sorption mechanism was mainly controlled by hydrophobic, π-π, and electrostatic interactions. Fixed bed column experiments with Al-modified biochar packed in different dosages (250, 500 and 1000 mg) and flow rates (1, 2 and 4 mL/min) showed the dosage of 1000 mg and flow rate of 1 mL/min performed the best for the removal of both SMX and SPY from wastewater. Among the breakthrough (BT) models used to evaluate the fixed bed filtration performance of Al-BB-600, the Yan model best described the BT behavior of the two sulfonamides, suggesting that the adsorption process involved multiple rate-liming factors such as mass transfer at the solid surface and diffusion Additionally, the Bed Depth Service Time (BDST) model results indicated that Al-BB-600 can be efficiently used in fixed bed column for the removal of both SMX and SPY in scaled-up continuous wastewater flow operations. Therefore, Al-modified biochar can be considered a reliable sorbent in real-world application for the removal of SMX and SPY from wastewater.
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http://dx.doi.org/10.1016/j.chemosphere.2022.135475DOI Listing
June 2022

Capillaries segmentation of NIR-II images and its application in ischemic stroke.

Comput Biol Med 2022 Jun 16;147:105742. Epub 2022 Jun 16.

Molecular Imaging Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. Electronic address:

Fluorescence imaging in the second near-infrared window (NIR-II) offers μm resolution blood vessel information noninvasively, which is crucial for the diagnosis and surgery treatment of some blood vessel-related diseases. However, only a few blood vessel segmentation algorithms have been done for the NIR-II images so far. Here, we proposed a vessel segmentation algorithm that used multi-scale enhancement and fractional differential to enhance capillaries, and then segmented vessels based on the blood vessels' tubular characteristics. Experimental results showed that this method could effectively suppress the point and lump tissue noise influence during vascular segmentation. The accuracy of vessel identification by other algorithms dropped below 30%, while our algorithm still achieved an accuracy of around 50% in deep vessel segmentation experiments with the 6.5 mm Intralipid. So it had the advantage of accurately detecting deep and dim blood capillaries. Meanwhile, the vascular density quantization algorithm had been successfully applied to the mice's ischemic stroke evaluations for the first time. In addition, this algorithm can provide the quantified vessel features under physiological or pathological conditions, which could be used to accurately evaluate the stroke drugs' therapeutic effect in the future.
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http://dx.doi.org/10.1016/j.compbiomed.2022.105742DOI Listing
June 2022

ALK-fusion-positive secondary ameloblastic carcinoma reached complete response after using alectinib.

Oral Oncol 2022 Jun 24;132:105946. Epub 2022 Jun 24.

Department of Oral & Maxillofacial-Head & Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; College of Stomatology, Shanghai Jiao Tong University, Shanghai, China; Shanghai Key Laboratory of Stomatology, Shanghai, China; National Clinical Research Center for Oral Diseases, Shanghai, China; Shanghai Key Laboratory of Stomatology, Shanghai, China. Electronic address:

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http://dx.doi.org/10.1016/j.oraloncology.2022.105946DOI Listing
June 2022

Mechanism of Ferroptosis and Its Role in Spinal Cord Injury.

Front Neurol 2022 9;13:926780. Epub 2022 Jun 9.

Department of Orthopedics, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Ferroptosis is a non-necrotic form of regulated cell death (RCD) that is primarily characterized by iron-dependent membrane lipid peroxidation and is regulated by cysteine transport, glutathione synthesis, and glutathione peroxidase 4 function as well as other proteins including ferroptosis suppressor protein 1. It has been found that ferroptosis played an important role in many diseases, such as neurodegenerative diseases and ischemia-reperfusion injury. Spinal cord injury (SCI), especially traumatic SCI, is an urgent problem worldwide due to its high morbidity and mortality, as well as the destruction of functions of the human body. Various RCDs, including ferroptosis, are found in SCI. Different from necrosis, since RCD is a form of cell death regulated by various molecular mechanisms in cells, the study of the role played by RCD in SCI will contribute to a deeper understanding of the pathophysiological process, as well as the treatment and functional recovery. The present review mainly introduces the main mechanism of ferroptosis and its role in SCI, so as to provide a new idea for further exploration.
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http://dx.doi.org/10.3389/fneur.2022.926780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9218271PMC
June 2022

Rashba-Edelstein Effect in the h-BN Van Der Waals Interface for Magnetization Switching.

Adv Mater 2022 Jun 25:e2109449. Epub 2022 Jun 25.

Department of Materials Science and Engineering, National University of Singapore, Singapore, 117575, Singapore.

Van der Waals (vdW) materials are attracting great attention in the field of spintronics due to their novel physical properties. For example, they have been utilized as spin-current generating materials in spin-orbit torque (SOT) devices, which offers an electrical way to control the magnetic state and is promising for future low-power electronics. However, SOTs have mostly been demonstrated in vdW materials with strong spin-orbit coupling (SOC). Here, we report the observation of the current-induced SOT in the h-BN/SrRuO bilayer structure, where the vdW material(h-BN) is an insulator with negligible SOC. Importantly, this SOT is strong enough to induce the switching of the perpendicular magnetization in SrRuO . Our first-principles calculations suggest a giant Rashba effect at the interface between vdW material and SrRuO (110) thin film, which leads to the observed SOT based on a simplified tight-binding model. Furthermore, we demonstrate that the current-induced magnetization switching can be modulated by the electric field. Our study paves the way for exploring the current-induced SOT and magnetization switching by integrating vdW materials with ferromagnets. This article is protected by copyright. All rights reserved.
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http://dx.doi.org/10.1002/adma.202109449DOI Listing
June 2022

Development and validation of a novel nomogram for predicting the occurrence of myopia in schoolchildren: a prospective cohort study.

Am J Ophthalmol 2022 Jun 21. Epub 2022 Jun 21.

Eye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China; National Clinical Research Center for Ocular Diseases, Wenzhou, Zhejiang, China. Electronic address:

Purpose: Myopia is a major public health issue and occurs at young ages. Apart from its high prevalence, myopia results in high costs and irreversible blinding diseases. Accurate prediction of the risk of myopia onset is crucial for its precise prevention. We aimed to develop and validate an effective nomogram for predicting myopia onset in schoolchildren.

Design: School-based prospective cohort study.

Methods: A total of 1073 schoolchildren were enrolled from November 2014 to May 2019 in China, and were divided into the training and validation cohorts. Myopia was defined as a spherical equivalent refraction (SER) ≤ -0.5 diopter. Predictors of myopia were determined through the Least Absolute Shrinkage and Selection Operator regression and multivariable Cox proportional hazard model based on the training cohort. The predictive performance of the nomogram was validated internally through time-dependent receiver operating characteristic (ROC) curves, calibration plot, decision curve analysis, and Kaplan-Meier curves.

Results: Independent predictors at baseline including gender, SER, axial length, corneal refractive power, and positive relative accommodation, were included in the nomogram prediction model. This nomogram demonstrated excellent calibration, clinical net benefit, and discrimination, with all the area under the ROC curves (AUCs) between 0.74 and 0.86 in the training and validation cohorts. The Kaplan-Meier curves showed that three distinct risk groups stratified through X-tile analysis were well discriminated and robust among subgroups. The Harrell's C-index and net reclassification improvement demonstrated that the nomogram substantially improved compared to previous models. An online myopia risk calculator was generated for better individual prediction.

Conclusions: The nomogram provides accurate and individual prediction of myopia onset in schoolchildren. External validation is needed to verify the generalizability of this nomogram.
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http://dx.doi.org/10.1016/j.ajo.2022.05.027DOI Listing
June 2022

SWOLLEN TAPETUM AND STERILITY 1 Is Required for Tapetum Degeneration and Pollen Wall Formation in Rice.

Plant Physiol 2022 Jun 24. Epub 2022 Jun 24.

State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Rice Research Institute, Sichuan Agricultural University, Chengdu 611130, China.

The pollen wall is important for protecting the male gametophyte and for fertilization. The lipid components of the pollen wall are mainly synthesized and transported from the sporophytic tapetum. Although several factors related to lipid biosynthesis have been characterized, the molecular mechanisms underlying lipid biosynthesis during pollen development in rice (Oryza sativa L.) remain elusive. Here, we showed that mutation in the SWOLLEN TAPETUM AND STERILITY 1 (STS1) gene causes delayed tapetum degradation and aborted pollen wall formation in rice. STS1 encodes an endoplasmic reticulum (ER)-localized protein that contains domain of unknown function (DUF) 726 and exhibits lipase activity. Lipidomic and transcriptomic analyses showed that STS1 is involved in anther lipid homeostasis. Moreover, STS1 interacts with Polyketide Synthase 2 (OsPKS2) and Acyl-CoA Synthetase 12 (OsACOS12), two enzymes crucial in lipidic sporopollenin biosynthesis in pollen wall formation, suggesting a potentially lipidic metabolon for sporopollenin biosynthesis in rice. Collectively, our results indicate that STS1 is an important factor for lipid biosynthesis in reproduction, providing a target for the artificial control of male fertility in hybrid rice breeding and insight into the function of DUF726-containing protein in plants.
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http://dx.doi.org/10.1093/plphys/kiac307DOI Listing
June 2022

Privacy-Preserving Outsourcing Algorithms for Multidimensional Data Encryption in Smart Grids.

Sensors (Basel) 2022 Jun 9;22(12). Epub 2022 Jun 9.

China Electric Power Research Institute, State Grid, 15 Xiaoying East Road No. 15, Beijing 300072, China.

With the development of the Internet of Things, smart grids have become indispensable in our daily life and can provide people with reliable electricity generation, transmission, distribution and control. Therefore, how to design a privacy-preserving data aggregation protocol has been a research hot-spot in smart grid technology. However, these proposed protocols often contain some complex cryptographic operations, which are not suitable for resource-constrained smart meter devices. In this paper, we combine data aggregation and the outsourcing of computations to design two privacy-preserving outsourcing algorithms for the modular exponentiation operations involved in the multi-dimensional data aggregation, which can allow these smart meter devices to delegate complex computation tasks to nearby servers for computing. By utilizing our proposed outsourcing algorithms, the computational overhead of resource-constrained smart meter devices can be greatly reduced in the process of data encryption and aggregation. In addition, the proposed algorithms can protect the input's privacy of smart meter devices and ensure that the smart meter devices can verify the correctness of results from the server with a very small computational cost. From three aspects, including security, verifiability and efficiency, we give a detailed analysis about our proposed algorithms. Finally, through carrying out some experiments, we prove that our algorithms can improve the efficiency of performing the data encryption and aggregation on the smart meter device side.
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http://dx.doi.org/10.3390/s22124365DOI Listing
June 2022

Reliability of Calculation of Dynamic Modulus for Asphalt Mixtures Using Different Master Curve Models and Shift Factor Equations.

Materials (Basel) 2022 Jun 18;15(12). Epub 2022 Jun 18.

Department of Civil and Environmental Engineering, Norwegian University of Science and Technology, Høgskoleringen 7A, 7491 Trondheim, Norway.

To develop a mechanistic-empirical pavement design system for Norwegian conditions, this paper evaluates the influence of the adoption of different models and shifting techniques on the determination of dynamic modulus master curves of asphalt mixtures. Two asphalt mixture types commonly used in Norway, namely Asphalt Concrete (AC) and Stone Mastic Asphalt (SMA) containing neat bitumen and polymer-modified bitumen, were prepared by the roller compactor, and their dynamic moduli were determined by the cyclic indirect tensile test. The dynamic modulus master curves were constructed using the standard logistic sigmoidal model, a generalized logistic sigmoidal model and the Christensen-Anderson-Marasteanu model. The shifting techniques consisted of log-linear, quadratic polynomial function, Arrhenius, William-Landel-Ferry and Kaelble methods. The absolute error, normalised square error and goodness-of-fit statistics encompassing standard error ratio and coefficient of determination were used to appraise the models and shifting methods. The results showed that the standard logistic sigmoidal model and the Williams-Landel-Ferry equation had the most suitable fits for the specimens tested. The asphalt mixtures containing neat bitumen had a better fit than the ones containing polymer-modified bitumen. The Kaelble equation and log-linear equation led to similar results. These findings provide a relevant recommendation for the mechanistic-empirical pavement design system.
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http://dx.doi.org/10.3390/ma15124325DOI Listing
June 2022

Preparation and Properties of Blended Composite Film Manufactured Using Walnut-Peptide-Chitosan-Sodium Alginate.

Foods 2022 Jun 15;11(12). Epub 2022 Jun 15.

Marine College, Shandong University (Weihai), No. 180 Wenhua West Road, Gao Strict, Weihai 264209, China.

In this study, layer-by-layer assembly was performed to prepare sodium alginate (SA) layer and walnut-peptide-chitosan (CS) bilayer composite films. Genipin was adopted to crosslink CS and walnut peptide. The properties of walnut peptide-CS-SA composite film were determined, and the influence of material ratio on the performance of composite film was explored. According to the results, the mechanical tensile property, oil absorption property, and water vapor barrier property of the composite film were improved with the presence of genipin. Moreover, the proportion of CS and walnut peptide had significant effects on color, transmittance, mechanical properties, barrier properties, and antioxidant properties of the composite films. Among them, the composite film containing 1% (/) CS, 1% (/) walnut peptide, and 0.01% (/) genipin showed the best performance, with a tensile strength of 3.65 MPa, elongation at break of 30.82%, water vapor permeability of 0.60 g·mm·m·h·kPa, oil absorption of 0.85%, and the three-phase electrochemistry of 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging rate of 25.59%. Under this condition, the tensile property, barrier property, and oxidation resistance of the composite film are good, which can provide a good preservation effect for food, and has great application potential.
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http://dx.doi.org/10.3390/foods11121758DOI Listing
June 2022

Population structure of 3907 worldwide pigs and the introgression of Chinese indigenous pigs by European pigs.

Anim Genet 2022 Jun 23. Epub 2022 Jun 23.

College of Life Science, Jiangxi Science and Technology Normal University, Nanchang, China.

With the improvement in sequencing technology and the decrease in sequencing cost, increasing amounts of genomic data for pigs have been uploaded to public databases. However, no researchers have to date integrated all currently available data to uncover the global genetic status of pigs. Meanwhile, little is known about the introgression from European to Chinese pigs and its underlying influences. Therefore, we integrated the effective genotype data of 3907 pigs from 193 populations worldwide using population genetic analysis, gene flow analysis and a sharing-IBD study. These findings illustrate not only the population structure of 59 Chinese native breeds and others but also the amounts of gene flow and introgression that have occurred between Western and Chinese pigs. In addition, we demonstrate the presence of introgressed European haplotypes in Chinese indigenous breeds and identify relevant introgressed regions that contain genes associated with growth and feed efficiency. Moreover, we compare the introgression patterns of Western and Chinese pigs and further discuss possible explanations for why the level of introgression differs between Chinese pig breeds and Western modern breeds. Collectively, this study provides a fine global population structure analysis of pigs and presents evidence of European pigs being interbred with local breeds in China.
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http://dx.doi.org/10.1111/age.13234DOI Listing
June 2022

Combined treatment with Rg1 and adipose-derived stem cells alleviates DSS-induced colitis in a mouse model.

Stem Cell Res Ther 2022 Jun 21;13(1):272. Epub 2022 Jun 21.

Colorectal Disease Center of Nanjing Hospital of Chinese Medicine, Affiliated to Nanjing University of Chinese Medicine, Nanjing, 210022, China.

Background: Inflammatory bowel diseases, consisting of Crohn's disease and ulcerative colitis constitute chronic inflammatory conditions that may compromise the whole gastrointestinal tract as well as the colonic mucosa. Currently, there are no curative interventions for IBD, and all available treatments have side effects that limit their use. Adipose-derived stem cell (ADSC) treatment is a prospective treatment option for IBD. Previous findings indicated that ginsenoside (Rg1) dampened inflammatory diseases like colitis by inhibiting the binding of LPS to TLR4 on macrophages and restoring the Th17/Treg ratio. The purpose of this work was to investigate whether Rg1 can increase the influence of ADSC in a mouse model of colitis triggered by dextran sulfate sodium (DSS).

Methods: ADSC was intravenously inoculated into mice with DSS-triggered colitis, while Rg1 was delivered via oral gavage. Colon inflammation was assessed via body weight, colon length along with H&E staining. Serum cytokine levels were measured using ELISA. Besides, flow cytometry was adopted to determine the percentage, as well as FMI of immune cells in the spleen. The effects of simultaneous Rg1 and ADSC treatment on TLR4-MyD88 signaling were assessed via immunofluorescence.

Results: Rg1 and ADSC effectively alleviated the impacts of colon inflammation, weight loss, and colon length reduction along with histological score. Treatment with Rg1 and ADSC reduced serum levels of the proinflammatory cytokines, IL-1β, TNF-α, IL-6, IL-4, and IL-17A and upregulated the level of immunosuppressive cytokine, IL-10. Compared with ADSC or Rg1 alone, combined treatment with Rg1 and ADSC significantly improved the structure of microbial community. Additionally, treatment with Rg1 plus ADSC selectively elevated the level of splenic regulatory T (Treg) cells and downregulated the proportion of T helper type 17 (Th17) cells, indicating restoration of intestinal homeostasis. Besides, we established that the combination of ADSC + Rg1 restored immunological balance more effectively than either ADSC or Rg1 alone, illustrating that Rg1's modulatory function on the gut microbiota may boost the impact of ADSCs in restoration of the immune balance. ADSC combined with Rg1 might downregulate the expression of TLR4 and MyD88, thereby suppressing TLR4-MyD8 signaling. The immunofluorescence results also suggested that co-therapy with Rg-1 and ADSC may optimize treatment strategies of IBD.

Conclusions: Here, we find that the combination of Rg1 and ADSC alleviates DSS-induced colitis in a mouse model more efficiently than ADSC alone, indicating that Rg1 enhances the effect of ADSC against colitis.
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http://dx.doi.org/10.1186/s13287-022-02940-xDOI Listing
June 2022

Transglutaminase-2 mediates acquisition of neratinib resistance in metastatic breast cancer.

Mol Biomed 2022 Jun 22;3(1):19. Epub 2022 Jun 22.

Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, 47907, USA.

Acquisition of resistance to targeted therapies remains a major clinical obstacle for the HER2 subtype of breast cancer. Using an isogeneic progression series of HER2 breast cancer metastasis we demonstrate that metastatic cells have an increased capacity to acquire resistance to the covalent, pan-ErbB inhibitor, neratinib. RNA sequencing analyses comparing parental and metastatic cells identified upregulation of transglutaminase 2 (TG2). Genetic depletion and overexpression approaches established that TG2 is both necessary and sufficient for acquisition of neratinib resistance. Mechanistically, we describe a pathway in which TG2-mediates activation of NF-κB signaling leading to upregulation of IL-6 in metastatic cells. This autocrine expression of IL-6 functions to maintain enhanced levels of TG2 via JAK:STAT3 signaling. This drug persistence feedback loop can be interrupted through the use of the JAK1/2 inhibitor ruxolitinib. In vivo application of ruxolitinib had no effect on tumor growth under non-treated conditions, but effectively prevented acquisition of resistance, leading to tumor regression upon coadministration with neratinib. Overall, our studies reveal a mechanism in metastatic breast cancer cells that predisposes them to acquisition of resistance to ErbB-targeted therapeutics. Clinically, immediate application of ruxolitinib could prevent acquisition of resistance and improve patient responses to HER2-targeted therapies.
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http://dx.doi.org/10.1186/s43556-022-00079-yDOI Listing
June 2022

Recent Advances in the Catalytic Hydroconversion of 5-Hydroxymethylfurfural to Valuable Diols.

Front Chem 2022 3;10:925603. Epub 2022 Jun 3.

National and Local Joint Engineering Laboratory for New Petro-Chemical Materials and Fine Utilization of Resources, Key Laboratory of the Assembly and Application of Organic Functional Molecules of Hunan Province, Hunan Normal University, Changsha, China.

Biomass, a globally available resource, is a promising alternative feedstock for fossil fuels, especially considering the current energy crisis and pollution. Biomass-derived diols, such as 2,5-bis(hydroxymethyl)furan, 2,5-bis(hydroxymethyl)-tetrahydrofuran, and 1,6-hexanediol, are a significant class of monomers in the polyester industry. Therefore, the catalytic conversion of biomass to valuable diols has received extensive research attention in the field of biomass conversion and is a crucial factor in determining the development of the polyester industry. 5-Hydroxymethylfurfural (HMF) is an important biomass-derived compound with a C6-furanic framework. The hydroconversion of HMF into diols has the advantages of being simple to operate, inexpensive, environmentally friendly, safe, and reliable. Therefore, in the field of diol synthesis, this method is regarded as a promising approach with significant industrialization potential. This review summarizes recent advances in diol formation, discusses the roles of catalysts in the hydroconversion process, highlights the reaction mechanisms associated with the specificities of each active center, and provides an outlook on the challenges and opportunities associated with the research on biomass-derived diol synthesis.
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http://dx.doi.org/10.3389/fchem.2022.925603DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9204135PMC
June 2022

The Effect of Animation-Guided Mindfulness Meditation on the Promotion of Creativity, Flow and Affect.

Front Psychol 2022 26;13:894337. Epub 2022 May 26.

Department of Industrial Engineering and Management, Ming Chi University of Technology, New Taipei, Taiwan.

Creativity is so important for social and technological development that people are eager to find an easy way to enhance it. Previous studies have shown that mindfulness has significant effects on positive affect (PA), working memory capacity, cognitive flexibility and many other aspects, which are the key to promoting creativity. However, there are few studies on the relationship between mindfulness and creativity. The mechanism between mindfulness and creativity is still uncertain. Meditation is an important method of mindfulness training, but for most people who do not have the basic training, it's difficult to master how to get into a state of mindfulness. Animation has been shown by many studies to help improve cognition and is often used as a guiding tool. Using animation as the guiding carrier of meditation is more convenient and easier to accept. Therefore, this study adopted the intervention method of animation-guided meditation, aiming to explore: (1) the effect of animation-guided meditation on enhancing creativity; (2) the role of flow and emotion in the influence of mindfulness on creativity. We advertised recruitment through the internal network of a creative industrial park, and the final 95 eligible participants were divided into two groups: animation ( = 48) and audio ( = 47) guided meditation. The animation group was given an animated meditation intervention, and the audio group was given an audio meditation intervention, both interventions were performed 3 times a week and last for 8 weeks. Results: (1) Animation-guided meditation significantly increased participants' mindfulness and creativity levels; Significantly reduced their cognitive load compared to audio-guided meditation. (2) Mindfulness has a significant direct effect on creativity, and significant indirect effects on creativity; Flow and PA act as the mediating variable. Conclusion: (1) Mindfulness, flow, and PA all helped to improve the subjects' work creativity. In addition to the direct positive impact of mindfulness on creativity, mindfulness can also have an indirect positive impact on creativity through flow and PA. (2) Compared with audio, animation can significantly reduce cognitive load and help improve users' cognitive ability, which is more suitable for the guidance materials of mindfulness meditation to enhance the effect of meditation.
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http://dx.doi.org/10.3389/fpsyg.2022.894337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9204527PMC
May 2022

Recent advances in RNA structurome.

Sci China Life Sci 2022 Jun 14. Epub 2022 Jun 14.

State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, 430072, China.

RNA structures are essential to support RNA functions and regulation in various biological processes. Recently, a range of novel technologies have been developed to decode genome-wide RNA structures and novel modes of functionality across a wide range of species. In this review, we summarize key strategies for probing the RNA structurome and discuss the pros and cons of representative technologies. In particular, these new technologies have been applied to dissect the structural landscape of the SARS-CoV-2 RNA genome. We also summarize the functionalities of RNA structures discovered in different regulatory layers-including RNA processing, transport, localization, and mRNA translation-across viruses, bacteria, animals, and plants. We review many versatile RNA structural elements in the context of different physiological and pathological processes (e.g., cell differentiation, stress response, and viral replication). Finally, we discuss future prospects for RNA structural studies to map the RNA structurome at higher resolution and at the single-molecule and single-cell level, and to decipher novel modes of RNA structures and functions for innovative applications.
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http://dx.doi.org/10.1007/s11427-021-2116-2DOI Listing
June 2022

Are patients with limited English proficiency less likely to undergo parathyroidectomy for primary hyperparathyoidism?

Am J Surg 2022 Jun 8. Epub 2022 Jun 8.

Harvard Medical School, Boston, MA, USA; Department of Surgery, Beth Israel Deaconess Medical Center, Boston, MA, USA. Electronic address:

Background: Despite meeting operative indications for primary hyperparathyroidism (PHPT), many patients never undergo parathyroidectomy. We hypothesized that patients with limited English proficiency (LEP) would be less likely to undergo parathyroidectomy than English-proficient (EP) patients.

Study Design: We retrospectively analyzed patients with PHPT from an institution-wide registry who met operative criteria between 2010 and 2018. The cohort was stratified by English proficiency. Univariate associations between sociodemographic and clinical factors with parathyroidectomy were assessed. A multivariable logistic regression model was created to assess independent predictors of parathyroidectomy.

Results: Among a cohort of 1,104 patients, 262 (24%) underwent parathyroidectomy. LEP patients (n = 135, 12%) were significantly younger (mean age 62 vs. 69, p < 0.001), more likely non-white race and ethnicity (p < 0.001), and less likely to have private insurance (p < 0.001). After adjusting for covariates, non-English and non-Spanish preferred language was an independent negative predictor of undergoing parathyroidectomy (OR 0.46, 95% CI 0.21-0.95, p = 0.037).

Conclusions: Limited English proficiency may be an independent barrier to appropriate surgical management of PHPT. Systems-level and disease-specific interventions are needed to address this disparity faced by patients with LEP.
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http://dx.doi.org/10.1016/j.amjsurg.2022.06.001DOI Listing
June 2022

Down-regulating of MFN2 promotes vascular calcification via regulating RAS-RAF-ERK1/2 pathway.

Int J Cardiol 2022 Jun 15. Epub 2022 Jun 15.

Department of Vascular Surgery, Hainan Affiliated Hospital of Hainan Medical University, Hainan General Hospital, Haikou 570311, Hainan Province, PR China.

Background: Vascular calcification (VC), as a prevalent feature of atherosclerosis (AS), is a life-threatening pathological change. Mitofusin 2 (MFN2) has been reported to be down-regulated and participate in the pathogenesis of AS. Here, we explored the feasible impacts of MFN2 on VC in AS.

Methods: Atherosclerotic lesion was evaluated by Oil Red O staining. The VC was detected by Alizarin Red S staining, ALP staining, and calcium content in vascular smooth muscle cells (VSMCs) or atherosclerotic mice. The chondrocyte differentiation of VSMCs was measured by Alcian blue staining. Western blotting and qRT-PCR were used to determine the protein and mRNA expression of associated molecules. Intermolecular interaction was measured by ChIP and dual luciferase assays.

Results: The expression of MFN2 and E2F1 was reduced in the aorta tissues of AS patients and mice. Silencing of MFN2 drove calcification in VSMCs and aortas of atherosclerotic mice as confirmed by up-regulating RUNX2, OPG levels, and down-regulating SM22α, α-SMA levels. The chondrocyte differentiation of VSMCs was accelerated by MFN2 knockdown through inducing the expression of Aggrecan, Collagen II, and SOX9. In addition, E2F1 promoted the transcription and expression of MFN2 in VSMCs. Overexpression of MFN2 or E2F1 suppressed ox-LDL-induced VSMC calcification. Finally, MFN2 depletion enhanced VSMC calcification via activating RAS-RAF-ERK1/2 pathway.

Conclusion: Our results suggest that silencing of MFN2 drives VC via activating RAS-RAF-ERK1/2 pathway in the progression of AS, thus MFN2 may be a therapeutic target for AS.
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http://dx.doi.org/10.1016/j.ijcard.2022.06.033DOI Listing
June 2022

Identification of a long noncoding RNA Gm17501 as a novel negative regulator of cardiac hypertrophy.

Exp Cell Res 2022 Jun 14:113262. Epub 2022 Jun 14.

Department of Cardiology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, 510080, China; NHC Key Laboratory of Assisted Circulation (Sun Yat-sen University), Guangzhou, Guangdong, 510080, China. Electronic address:

Pathological cardiac hypertrophy is an independent risk factor for the development of heart failure. Long noncoding RNAs (lncRNAs), an emerging class of non-protein-coding transcripts, are involved in regulation of multiple cardiac diseases through diverse molecular mechanism, whereas the role of cytoplasmic lncRNAs in regulating cardiac hypertrophy remains unclear. In this study, we identified a novel and functional long noncoding RNA Gm17501, which was predominantly expressed in the cytoplasm of cardiomyocytes. The expression level of lncRNA Gm17501 was altered in cardiac hypertrophy induced by pressure overload and phenylephrine treatment. Moreover, lncRNA Gm17501 expression was decreased in the heart tissue of patients with heart failure. Silencing lncRNA Gm17501 aggravated cardiac hypertrophy under pathological stress. Inhibition of lncRNA Gm17501 did not alter the expression of nearby genes but decreased mRNA level of calcium handling proteins which were involved in cardiac contraction. Therefore, the cytoplasmic lncRNA Gm17501 might protect cardiomyocytes against hypertrophy, possibly by maintaining calcium signaling pathway.
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http://dx.doi.org/10.1016/j.yexcr.2022.113262DOI Listing
June 2022

probing the dynamic reconstruction of copper-zinc electrocatalysts for CO reduction.

Nanoscale 2022 Jun 17. Epub 2022 Jun 17.

Department of Chemistry, National Taiwan University, Taipei 106, Taiwan.

Unravelling the dynamic characterization of electrocatalysts during the electrochemical CO reduction reaction (CORR) is a critical factor to improve the production efficiency and selectivity, since most pre-electrocatalysts undergo structural reconstruction and surface rearrangement under working conditions. Herein, a series of pre-electrocatalysts including CuO, ZnO and two different ratios of CuO/ZnO were systematically designed by a sputtering process to clarify the correlation of the dynamic characterization of Cu sites in the presence of Zn/ZnO and the product profile. The evidence provided by X-ray absorption spectroscopy (XAS) indicated that appropriate Zn/ZnO levels could induce a variation in the coordination number of Cu sites reversing Ostwald ripening. Specifically, the recrystallized Cu site with a lower coordination number exhibited a preferential production of methane (CH). More importantly, our findings provide a promising approach for the efficient production of CH by reconstructing Cu-based binary electrocatalysts.
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http://dx.doi.org/10.1039/d2nr01478eDOI Listing
June 2022

[Clinical observation on different frequency of auricular bloodletting combined with auricular point sticking for acne vulgaris].

Zhongguo Zhen Jiu 2022 Jun;42(6):629-33

College of Acupuncture-Moxibustion and Tuina, Hebei University of CM, Shijiazhuang 050200, China; International Joint Research Center for Advantageous Diseases of Acupuncture and Moxibustion in Hebei Province, Shijiazhuang 050200.

Objective: To observe the clinical efficacy of different treatment frequency of auricular bloodletting combined with auricular point sticking for acne vulgaris.

Methods: A total of 90 patients with acne vulgaris were randomized into a treatment group 1 (30 cases, 2 cases dropped off), a treatment group 2 (30 cases, 4 cases dropped off) and a treatment group 3 (30 cases, 5 cases dropped off). Combination therapy of auricular bloodletting and auricular point sticking at Fei (CO), Shenmen (TF), Neifenmi (CO) and Shenshangxian (TGp) were given once a week, twice a week and 3 times a week in the treatment group 1, the treatment group 2 and the treatment group 3 respectively, 4 weeks were as one course and totally 3 courses were required in the 3 groups. Before treatment and after 1, 2, 3 courses of treatment, the scores of global acne grading system (GAGS), skin lesion and quality of life-acne (QoL-Acne) were observed, the clinical efficacy was evaluated after 3 courses of treatment and the recurrence rate was evaluated in follow-up of 1 month after treatment in the 3 groups.

Results: Compared before treatment, the scores of GAGS and skin lesion were decreased at each time point in the 3 groups (<0.05), the QoL-Acne scores were increased after 1 course of treatment in the treatment group 3 and after 2, 3 courses of treatment in the 3 groups (<0.05). There were no statistical differences in scores of GAGS, skin lesion and QoL-Acne among the 3 groups (>0.05). There were no statistical differences in effective rate and recurrence rate among the 3 groups (>0.05).

Conclusion: Different frequency of auricular bloodletting combined with auricular point sticking have similar efficacy in treating acne vulgaris, all can improve the skin lesion and quality of life in patients with acne vulgaris, and have a cumulative effect and good long-term curative effect.
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http://dx.doi.org/10.13703/j.0255-2930.20210519-k0006DOI Listing
June 2022

The Curcumin Analog Da0324 Inhibits the Proliferation of Gastric Cancer Cells HOTAIRM1/miR-29b-1-5p/PHLPP1 Axis.

J Cancer 2022 16;13(8):2644-2655. Epub 2022 May 16.

Central Laboratory, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.

Our previous study has shown that Da0324, a curcumin analog, exhibited significantly improved stability and antitumor activity. However, the molecular mechanisms of action of Da0324 remain poorly understood. Long non-coding RNA (lncRNA) has been shown to play a key role in tumor progression. Here, we aim to investigate the molecular mechanisms underlying the anti-cancer activity of Da0324 by regulating the lncRNA HOTAIRM1. Gastric cancer cell lines were treated with Da0324 and/or transfected with lentiviral vector expressing HOTAIRM1 shRNA, and/or miR-29b-1-5p mimics and/or small interference RNA (siRNA) against PHLPP1, or HOTAIRM1 siRNA or lentiviral vector expressing HOTAIRM1, as needed. The expression of HOTAIRM1, miR-29b-1-5p and PHLPP1 in GC cells was determined by Real-Time PCR. Cell growth was examined by CCK-8 assay and colony formation assay . The targeted relationship between HOTAIRM1 and miR-29b-1-5p was verified by luciferase reporter gene assay. PHLPP1 protein expression was examined by Western blotting. Da0324 increased the expression of HOTAIRM1 in GC cells. HOTAIRM1 expression was significantly down-regulated in GC tissues, and the low expression of HOTAIRM1 was associated with the shorter survival rate of GC patients based on the TCGA database. Knockdown of HOTAIRM1 promoted GC cell proliferation whereas overexpression of HOTAIRM1 inhibited GC cell proliferation as demonstrated by CCK-8 and colony formation assays. Moreover, knockdown of HOTAIRM1 reversed the Da0324-mediated growth inhibition of GC cells. Furthermore, HOTAIRM1 acted as a sponge for miR-29b-1-5p and PHLPP1 is regulated by the HOTAIRM1/miR-29b-1-5p axis in GC cells. Overexpression of miR-29b-1-5p or knockdown of PHLPP1 reversed the ability of Da0324 to inhibit the growth of GC cells. Our data suggest that Da0324 exerts antitumor activity by regulating HOTAIRM1/miR-29b-1-5p/PHLPP1 axis in GC cells, and provide new insights into the anti-cancer mechanism of Da0324.
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http://dx.doi.org/10.7150/jca.69970DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9174869PMC
May 2022

Hierarchical marketing mix models with sign constraints.

J Appl Stat 2021 29;48(13-15):2944-2960. Epub 2021 Jun 29.

Research & Development, NielsenIQ, Chicago, IL, USA.

Marketing mix models (MMMs) are statistical models for measuring the effectiveness of various marketing activities such as promotion, media advertisement, etc. In this research, we propose a comprehensive marketing mix model that captures the hierarchical structure and the carryover, shape and scale effects of certain marketing activities, as well as sign restrictions on certain coefficients that are consistent with common business sense. In contrast to commonly adopted approaches in practice, which estimate parameters in a multi-stage process, the proposed approach estimates all the unknown parameters simultaneously using a constrained maximum likelihood approach and a Hamiltonian Monte Carlo algorithm. We present results on real datasets to illustrate the use of the proposed solution algorithms.
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http://dx.doi.org/10.1080/02664763.2021.1946020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9041956PMC
June 2021

Optimization of scan parameters to reduce acquisition time for RESOLVE-based diffusion kurtosis imaging (DKI) in nasopharyngeal carcinoma (NPC).

Br J Radiol 2022 Jun 22:20210641. Epub 2022 Jun 22.

Department of Radiology, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China.

Objective: To shorten acquisition time of readout segmentation of long variable echo trains (RESOLVE)-based diffusion kurtosis imaging (DKI) via Readout Partial Fourier (RPF) and b-value combinations.

Methods: The RESOLVE-based DKI images of 38 patients with nasopharyngeal carcinoma (NPC) were prospectively enrolled. For RESOLVE-based DKI images with 5/8 RPF and without RPF, objective and subjective evaluations of image quality were performed. A total of nine groups with different b-value combinations were simulated, and the influence of different b-value combinations for RESOLVE-RPF-based DKI sequences was assessed using the intraclass correlation coefficient (ICC).

Results: The mean values of signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) in DKI images without RPF were higher than those with 5/8 RPF (252.9 ± 77.7 vs 247.3 ± 85.5 and 5.8 ± 2.8 vs 5.4 ± 2.3, respectively), but not significantly ( = 0.460 and = 0.180, respectively). In comparing the ICCs between nine groups of different b-value combinations in RESOLVE-RPF-based DKI, group (200, 800, 2000 s/mm), group (200, 400, 800, 2000 s/mm) and group (200, 800, 1500, 2000 s/mm) were not significantly different ( > 0.001) and showed excellent agreement (0.81-1.00) with that of group (200, 400, 800, 1500, 2000 s/mm). Using b-value optimization and RPF technology, the group with RPF (200, 400, 800, 2000 s/mm) showed a 56% reduced scanning compared with the group without RPF (200, 400, 800, 1500, 2000 s/mm; 3 min 46 s 8 min 31 s, respectively).

Conclusion: DKI with RPF did not significantly affect image quality, but both RPF and different b-value combinations can affect the scanning time. The combination of RPF and b-value optimization can ensure the stability of DKI parameters and reduce the scanning time by 56%.

Advances In Knowledge: This work is to optimize scan parameters, RPF and b-value combinations, to reduce acquisition time for RESOLVE-based DKI in NPC. To our knowledge, the effect of RESOLVE-RPF and b-value combinations on DKI has not been reported.
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http://dx.doi.org/10.1259/bjr.20210641DOI Listing
June 2022
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