Haiyun Gan

Haiyun Gan

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Haiyun Gan

Haiyun Gan

Publications by authors named "Haiyun Gan"

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A Cancer-Specific Ubiquitin Ligase Drives mRNA Alternative Polyadenylation by Ubiquitinating the mRNA 3' End Processing Complex.

Mol Cell 2020 Mar 21;77(6):1206-1221.e7. Epub 2020 Jan 21.

Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2019.12.022DOI Listing
March 2020

Pak2 kinase promotes cellular senescence and organismal aging.

Proc Natl Acad Sci U S A 2019 07 17;116(27):13311-13319. Epub 2019 Jun 17.

Institute for Cancer Genetics, Columbia University Irving Medical Center, New York, NY 10032;

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http://dx.doi.org/10.1073/pnas.1903847116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613284PMC
July 2019

The Mcm2-Ctf4-Polα Axis Facilitates Parental Histone H3-H4 Transfer to Lagging Strands.

Mol Cell 2018 10 20;72(1):140-151.e3. Epub 2018 Sep 20.

Institute for Cancer Genetics, Department of Pediatrics and Genetics and Development, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2018.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193272PMC
October 2018

A mechanism for preventing asymmetric histone segregation onto replicating DNA strands.

Science 2018 09 16;361(6409):1386-1389. Epub 2018 Aug 16.

Institute for Cancer Genetics, Department of Pediatrics and Genetics and Development, Columbia University, New York, NY 10032, USA.

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http://dx.doi.org/10.1126/science.aat8849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597248PMC
September 2018

Asf1a resolves bivalent chromatin domains for the induction of lineage-specific genes during mouse embryonic stem cell differentiation.

Proc Natl Acad Sci U S A 2018 07 18;115(27):E6162-E6171. Epub 2018 Jun 18.

Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN 55905;

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http://dx.doi.org/10.1073/pnas.1801909115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142193PMC
July 2018

A novel enhancer regulates MGMT expression and promotes temozolomide resistance in glioblastoma.

Nat Commun 2018 07 27;9(1):2949. Epub 2018 Jul 27.

Institute for Cancer Genetics, Department of Pediatrics and Department of Genetics and Development, Irving Cancer Research Center, Columbia University, 1130 St. Nicholas Avenue, New York, NY, 10032, USA.

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http://dx.doi.org/10.1038/s41467-018-05373-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063898PMC
July 2018

Strand-Specific Analysis of DNA Synthesis and Proteins Association with DNA Replication Forks in Budding Yeast.

Methods Mol Biol 2018 ;1672:227-238

Institute for Cancer Genetics, Columbia University, 1130 St. Nicholas Avenue, New York, NY, USA.

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http://dx.doi.org/10.1007/978-1-4939-7306-4_17DOI Listing
June 2018

H3.3K27M mutant proteins reprogram epigenome by sequestering the PRC2 complex to poised enhancers.

Elife 2018 06 22;7. Epub 2018 Jun 22.

Department of Pediatrics and Department of Genetics and Development, Institute for Cancer Genetics, Irving Cancer Research Center, Columbia University, New York, United States.

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http://dx.doi.org/10.7554/eLife.36696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033537PMC
June 2018

Both DNA Polymerases δ and ε Contact Active and Stalled Replication Forks Differently.

Mol Cell Biol 2017 Nov 13;37(21). Epub 2017 Oct 13.

Institute for Cancer Genetics, Department of Pediatrics, and Department of Genetics and Development, Columbia University, Irving Cancer Research Center, New York, New York, USA

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http://dx.doi.org/10.1128/MCB.00190-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640813PMC
November 2017

Probe the function of histone lysine 36 methylation using histone H3 lysine 36 to methionine mutant transgene in mammalian cells.

Cell Cycle 2017 Oct 27;16(19):1781-1789. Epub 2017 Jan 27.

a Department of Pediatrics and Department of Genetics and Development , Institute for Cancer Genetics, Irving Cancer Research Center, Columbia University , New York , NY , USA.

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http://dx.doi.org/10.1080/15384101.2017.1281483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628648PMC
October 2017

Checkpoint Kinase Rad53 Couples Leading- and Lagging-Strand DNA Synthesis under Replication Stress.

Mol Cell 2017 Oct 12;68(2):446-455.e3. Epub 2017 Oct 12.

Institute for Cancer Genetics and Department of Pediatrics and Genetics and Development, Columbia University, New York, NY 10032. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10972765173066
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http://dx.doi.org/10.1016/j.molcel.2017.09.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802358PMC
October 2017

MicroRNA-202 maintains spermatogonial stem cells by inhibiting cell cycle regulators and RNA binding proteins.

Nucleic Acids Res 2017 04;45(7):4142-4157

State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.

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http://dx.doi.org/10.1093/nar/gkw1287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5397178PMC
April 2017

H3K9me3 demethylase Kdm4d facilitates the formation of pre-initiative complex and regulates DNA replication.

Nucleic Acids Res 2017 01 26;45(1):169-180. Epub 2016 Sep 26.

Institute for Cancer Genetics, Department of Pediatric and Department of Genetics and Development, Columbia University, New York, NY 10032, USA

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http://dx.doi.org/10.1093/nar/gkw848DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224507PMC
January 2017

RPA Interacts with HIRA and Regulates H3.3 Deposition at Gene Regulatory Elements in Mammalian Cells.

Mol Cell 2017 Jan;65(2):272-284

Departments of Pediatrics and Genetics and Development, Institute for Cancer Genetics, Irving Cancer Research Center, College of Surgeons and Physicians, Columbia University, 1130 St. Nicholas Avenue, New York, NY 10032, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2016.11.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460635PMC
January 2017

BMP4 Cooperates with Retinoic Acid to Induce the Expression of Differentiation Markers in Cultured Mouse Spermatogonia.

Stem Cells Int 2016 4;2016:9536192. Epub 2016 Oct 4.

State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, China.

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http://dx.doi.org/10.1155/2016/9536192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5067322PMC
October 2016

Noncoding Transcription Is a Driving Force for Nucleosome Instability in spt16 Mutant Cells.

Mol Cell Biol 2016 07 15;36(13):1856-67. Epub 2016 Jun 15.

State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences and Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China

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http://dx.doi.org/10.1128/MCB.00152-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911744PMC
July 2016

The histone H3.3K36M mutation reprograms the epigenome of chondroblastomas.

Science 2016 Jun 26;352(6291):1344-8. Epub 2016 May 26.

Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA. Epigenomics Program, Center of Individualized Medicine, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1126/science.aae0065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460624PMC
June 2016

Strand-specific analysis shows protein binding at replication forks and PCNA unloading from lagging strands when forks stall.

Mol Cell 2014 Nov 23;56(4):551-63. Epub 2014 Oct 23.

Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA; Center for Individualized Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2014.09.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4362665PMC
November 2014

Dynamics of 5-hydroxymethylcytosine during mouse spermatogenesis.

Nat Commun 2013 ;4:1995

State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, China.

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http://dx.doi.org/10.1038/ncomms2995DOI Listing
December 2013

A lesson learned from the H3.3K27M mutation found in pediatric glioma: a new approach to the study of the function of histone modifications in vivo?

Cell Cycle 2013 Aug 10;12(16):2546-52. Epub 2013 Jul 10.

Department of Biochemistry and Molecular Biology, Epigenomic Developmental Program, Center of Individualized Medicine, Mayo Clinic, Rochester, MN, USA.

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http://dx.doi.org/10.4161/cc.25625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3865043PMC
August 2013

Integrative proteomic and transcriptomic analyses reveal multiple post-transcriptional regulatory mechanisms of mouse spermatogenesis.

Mol Cell Proteomics 2013 May 16;12(5):1144-57. Epub 2013 Jan 16.

State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, PR China.

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http://dx.doi.org/10.1074/mcp.M112.020123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650327PMC
May 2013

The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression.

Genes Dev 2013 May 19;27(9):985-90. Epub 2013 Apr 19.

Department of Biochemistry and Molecular Biology, University of California at San Francisco, San Francisco, California 94143, USA.

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http://dx.doi.org/10.1101/gad.217778.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656328PMC
May 2013

Mining and characterization of ubiquitin E3 ligases expressed in the mouse testis.

BMC Genomics 2012 Sep 19;13:495. Epub 2012 Sep 19.

State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.

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http://dx.doi.org/10.1186/1471-2164-13-495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460789PMC
September 2012

piRNA profiling during specific stages of mouse spermatogenesis.

RNA 2011 Jul 20;17(7):1191-203. Epub 2011 May 20.

State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, China.

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http://dx.doi.org/10.1261/rna.2648411DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3138557PMC
July 2011