Publications by authors named "H G Yan"

10,799 Publications

Chromosome-level and graphic genomes provide insights into metabolism of bioactive metabolites and cold-adaption of Pueraria lobata var. montana.

DNA Res 2022 Aug 12. Epub 2022 Aug 12.

Key Laboratory of Horticultural Plant Biology, Ministry of Education, College of Horticulture and Forestry Sciences, Huazhong Agricultural University, Wuhan, 430070, China.

Pueraria lobata var. montana (P. montana) belongs to the genus Pueraria and originated in Asia. Compared with its sister P. thomsonii, P. montana has stronger growth vigor and cold-adaption, but contains less bioactive metabolites such as puerarin. To promote the investigation of metabolic regulation and genetic improvement of Pueraria, the present study reports a chromosome-level genome of P. montana with length of 978.59 Mb and scaffold N50 of 80.18 Mb. Comparative genomics analysis showed that P. montana possesses smaller genome size than that of P. thomsonii owing to less repeat sequences and duplicated genes. A total of 6,548 and 4,675 variety-specific gene families were identified in P. montana and P. thomsonii, respectively. The identified variety-specific and expanded/contracted gene families related to biosynthesis of bioactive metabolites and microtubules are likely the causes for the different characteristics of metabolism and cold-adaption of P. montana and P. thomsonii. Moreover, a graphic genome was constructed based on 11 P. montana accessions. Total 92 structural variants were identified and most of which are related to stimulus-response. In conclusion, the chromosome-level and graphic genomes of P. montana will not only facilitate the studies of evolution and metabolic regulation, but also promote the breeding of Pueraria.
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http://dx.doi.org/10.1093/dnares/dsac030DOI Listing
August 2022

Experimental Limits on Exotic Spin and Velocity Dependent Interactions Using Rotationally Modulated Source Masses and an Atomic-Magnetometer Array.

Phys Rev Lett 2022 Jul;129(5):051802

Key Laboratory of Neutron Physics, Institute of Nuclear Physics and Chemistry, CAEP, Mianyang, Sichuan 621900, China and Institute of Nuclear Physics and Chemistry, CAEP, Mianyang, Sichuan 621900, China.

Various theories beyond the standard model predict new interactions mediated by new light particles with very weak couplings to ordinary matter. Interactions between polarized electrons and unpolarized nucleons proportional to g_{V}^{N}g_{A}^{e}σ[over →]·v[over →] and g_{A}^{N}g_{A}^{e}σ[over →]·v[over →]×r[over →] are two such examples, where σ[over →] is the spin of the electrons, r[over →] and v[over →] are position and relative velocity between the polarized electrons and nucleons, g_{V}^{N}/g_{A}^{N} is the vector or axial-vector coupling constant of the nucleon, and g_{A}^{e} is the axial-vector coupling constant of the electron. Such interactions involving a vector or axial-vector coupling g_{V}^{N}/g_{A}^{N} at one vertex and an axial-vector coupling g_{A}^{e} at the polarized electron vertex can be induced by the exchange of spin-1 bosons. We report new experimental upper limits on such exotic spin-velocity-dependent interactions of the electron with nucleons from dedicated experiments based on a recently proposed scheme. We rotationally modulated two ∼6  Kg source masses at a frequency of 20 Hz. We used four identical atomic magnetometers in an array form to increase the statistics and cancel the common-mode noise. We applied a data processing method based on high precision numerical integration for the four harmonic frequencies of the signal. We reverse the rotation direction of the source masses to flip the signal due to the new interactions; thus, we can apply the [+1,-3,+3,-1] weighting method to remove possible slow drifting. Our constraint on the product of vector and axial-vector couplings is |g_{V}^{N}g_{A}^{e}|<2.1×10^{-34} and on the product of axial-vector and axial-vector couplings is |g_{A}^{N}g_{A}^{e}|<2.4×10^{-22} for an interaction range of 10 m. The new constraints on vector-axial-vector interaction improved by as much as more than 4 orders of magnitude and on axial-axial interaction by as much as 2 orders of magnitude in the corresponding interaction range, respectively.
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http://dx.doi.org/10.1103/PhysRevLett.129.051802DOI Listing
July 2022

Comparison Of The Gut Microbiota In Different Age Groups In China.

Front Cell Infect Microbiol 2022 25;12:877914. Epub 2022 Jul 25.

Health Management Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Aging is now the most profound risk factor for almost all non-communicable diseases. Studies have shown that probiotics play a specific role in fighting aging. We used metagenomic sequencing to study the changes in gut microbes in different age groups and found that aging had the most significant effect on subjects' gut microbe structure. Our study divided the subjects (n=614) into two groups by using 50 years as the age cut-off point for the grouping. Compared with the younger group, several species with altered abundance and specific functional pathways were found in the older group. At the species level, the abundance of , , , , , and were increased in older individuals. They were positively correlated to the pathways responsible for lipopolysaccharide (LPS) biosynthesis and the degradation of short-chain fatty acids (SCFAs). On the contrary, the levels of , , and were decreased in the older group, which negatively correlated with the above pathways (p-value<0.05). Functional prediction revealed 92 metabolic pathways enriched in the older group significantly higher than those in the younger group (p-value<0.05), especially pathways related to LPS biosynthesis and the degradation of SCFAs. Additionally, we established a simple non-invasive model of aging, nine species (, , , , , , , , and ) were selected to construct the model. The area under the receiver operating curve (AUC) of the model implied that supplemented probiotics might influence aging. We discuss the features of the aging microbiota that make it more amenable to pre-and probiotic interventions. We speculate these metabolic pathways of gut microbiota can be associated with the immune status and inflammation of older adults. Health interventions that promote a diverse microbiome could influence the health of older adults.
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http://dx.doi.org/10.3389/fcimb.2022.877914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9359670PMC
July 2022

YOLOv5-AC: Attention Mechanism-Based Lightweight YOLOv5 for Track Pedestrian Detection.

Sensors (Basel) 2022 Aug 7;22(15). Epub 2022 Aug 7.

School of Automation, Chengdu University of Information Technology, Chengdu 610225, China.

In response to the dangerous behavior of pedestrians roaming freely on unsupervised train tracks, the real-time detection of pedestrians is urgently required to ensure the safety of trains and people. Aiming to improve the low accuracy of railway pedestrian detection, the high missed-detection rate of target pedestrians, and the poor retention of non-redundant boxes, YOLOv5 is adopted as the baseline to improve the effectiveness of pedestrian detection. First of all, L1 regularization is deployed before the BN layer, and the layers with smaller influence factors are removed through sparse training to achieve the effect of model pruning. In the next moment, the context extraction module is applied to the feature extraction network, and the input features are fully extracted using receptive fields of different sizes. In addition, both the context attention module CxAM and the content attention module CnAM are added to the FPN part to correct the target position deviation in the process of feature extraction so that the accuracy of detection can be improved. What is more, DIoU_NMS is employed to replace NMS as the prediction frame screening algorithm to improve the problem of detection target loss in the case of high target coincidence. Experimental results show that compared with YOLOv5, the AP of our YOLOv5-AC model for pedestrians is 95.14%, the recall is 94.22%, and the counting frame rate is 63.1 FPS. Among them, AP and recall increased by 3.78% and 3.92%, respectively, while the detection speed increased by 57.8%. The experimental results verify that our YOLOv5-AC is an effective and accurate method for pedestrian detection in railways.
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http://dx.doi.org/10.3390/s22155903DOI Listing
August 2022

Millimeter-Wave Radar Localization Using Indoor Multipath Effect.

Sensors (Basel) 2022 Jul 29;22(15). Epub 2022 Jul 29.

College of Computer Science & Engineering, Northwest Normal University, Lanzhou 730070, China.

The positioning of indoor electronic devices is an essential part of human-computer interaction, and the accuracy of positioning affects the level of user experience. Most existing methods for RF-based device localization choose to ignore or remove the impact of multipath effects. However, exploiting the multipath effect caused by the complex indoor environment helps to improve the model's localization accuracy. In response to this question, this paper proposes a multipath-assisted localization (MAL) model based on millimeter-wave radar to achieve the localization of indoor electronic devices. The model fully considers the help of the multipath effect when describing the characteristics of the reflected signal and precisely locates the target position by using the MAL area formed by the reflected signal. At the same time, for the situation where the radar in the traditional Single-Input Single-Output (SISO) mode cannot obtain the 3D spatial position information of the target, the advantage of the MAL model is that the 3D information of the target can be obtained after the mining process of the multipath effect. Furthermore, based on the original hardware, it can achieve a breakthrough in angular resolution. Experiments show that our proposed MAL model enables the millimeter-wave multipath positioning model to achieve a 3D positioning error within 15 cm.
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http://dx.doi.org/10.3390/s22155671DOI Listing
July 2022
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