Publications by authors named "Guoliang Chen"

125 Publications

Multicenter phase II study of apatinib single or combination therapy in HER2-negative breast cancer involving chest wall metastasis.

Chin J Cancer Res 2021 Apr;33(2):243-255

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Breast Oncology, Peking University Cancer Hospital & Institute, Beijing 100142, China.

Objective: Breast cancer (BC) with chest wall metastasis (CWM) usually shows rich neovascularization. This trial explored the clinical effect of apatinib on human epidermal growth factor receptor 2 (HER2)-negative advanced BC involving CWM.

Methods: This trial involved four centers in China and was conducted from September 2016 to March 2020. Patients received apatinib 500 mg/d [either alone or with endocrine therapy if hormone receptor-positive (HR+)] until disease progression or unacceptable toxicity. Progression-free survival (PFS) was the primary endpoint.

Results: We evaluated 26 patients for efficacy. The median PFS (mPFS) and median overall survival (mOS) were 4.9 [range: 2.0-28.5; 95% confidence interval (95% CI): 2.1-8.3] months and 18 (range: 3-55; 95% CI: 12.9-23.1) months, respectively. The objective response rate (ORR) was 42.3% (11/26), and the disease-control rate was 76.9% (20/26). In the subgroup analysis, HR+ patients compared with HR-negative patients had significantly improved mPFS of 7.0 (95% CI: 2.2-11.8) months 2.3 (95% CI: 1.2-3.4) months, respectively (P=0.001); and mPFS in patients without or with chest wall radiotherapy was 6.4 (95% CI: 1.6-19.5) months 3.0 (95% CI: 1.3-4.6) months, respectively (P=0.041). In the multivariate analysis, HR+ status was the only independent predictive factor for favorable PFS (P=0.014).

Conclusions: Apatinib was highly effective for BC patients with CWM, especially when combined with endocrine therapy. PFS improved significantly in patients with HR+ status who did not receive chest wall radiotherapy. However, adverse events were serious and should be carefully monitored from the beginning of apatinib treatment.
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http://dx.doi.org/10.21147/j.issn.1000-9604.2021.02.11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8181870PMC
April 2021

Transcriptome Analysis and Autophagy Investigation of LoVo Cells Stimulated with Exosomes Derived from Adult Worms.

Microorganisms 2021 May 5;9(5). Epub 2021 May 5.

State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, CAAS, Lanzhou 730046, China.

is a zoonotic parasite found in the human intestine and pig liver that evolved various strategies to survive the host's defenses. Exosomes are membranous vesicles released by cells and are an important vehicle in parasite-host interactions. However, no literature exists on the specific infection mechanisms of against the host defense response, and further research is required to understand the parasite-host interaction. In this study, we investigated the host's differentially expressed genes (DEGs) while stimulating them with exosomes derived from the adult worm (Tas-exo) on LoVo by RNA-seq analysis. Our results identified 348 genes as being significantly differentially expressed for the Tas-exo group when comparing with that of the NC group. Some of these genes are related to modulation of cell proliferation and cell autophagy. Surprisingly, autophagy and cell proliferation have crucial roles in the defense against parasites; accordingly, we detected cell proliferation and autophagy in LoVo cells by CCK8, immunofluorescence, and Western blotting, demonstrating that Tas-exo could inhibit LoVo cell proliferation and autophagy via AMPK pathway. When P62 and p-mTOR/mTOR expression were significantly increased, BeclinI and pAMPK/AMPK were significantly decreased. These results expand our understanding of parasite-host interactions mediated by exosomes.
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http://dx.doi.org/10.3390/microorganisms9050994DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8147967PMC
May 2021

Developmental neurotoxicity of antimony (Sb) in the early life stages of zebrafish.

Ecotoxicol Environ Saf 2021 May 8;218:112308. Epub 2021 May 8.

Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing 400030, China. Electronic address:

Accumulating studies have revealed the toxicity of antimony (Sb) to soil-dwelling and aquatic organisms at the individual level. However, little is known about the neurotoxic effects of antimony and its underlying mechanisms. To assess this issue, we investigated the neurotoxicity of antimony (0, 200, 400, 600 and 800 mg/L) in zebrafish embryos. After exposure, zebrafish embryos showed abnormal phenotypes such as a shortened body length, morphological malformations, and weakened heart function. Behavioral experiments indicated that antimony caused neurotoxicity in zebrafish embryos, manifested in a decreased spontaneous movement frequency, delayed response to touch, and reduced movement distance. We also showed that antimony caused a decrease in acetylcholinesterase (AChE) levels in zebrafish embryos, along with decreased expression of neurofunctional markers such as gfap, nestin, mbp, and shha. Additionally, antimony significantly increased reactive oxygen species levels and significantly reduced glutathione (GSH) and superoxide dismutase (SOD) activity. In summary, our findings indicated that antimony can induce developmental toxicity and neurotoxicity in zebrafish embryos by affecting neurotransmitter systems and oxidative stress, thus altering behavior. These outcomes will advance our understanding of antimony-induced neurotoxicity, environmental problems, and health hazards.
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http://dx.doi.org/10.1016/j.ecoenv.2021.112308DOI Listing
May 2021

Inadequate spinal cord expansion in intraoperative ultrasound after decompression may predict neurological recovery of degenerative cervical myelopathy.

Eur Radiol 2021 Apr 30. Epub 2021 Apr 30.

Guangdong Provincial Biomedical Innovation Platform of Regeneration and Repair of Spinal Cord and Nerve Injury, Department of Orthopedic Surgery, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, People's Republic of China.

Objective: To compare the neurological recovery between patients with adequate and inadequate immediate spinal cord expansion after sufficient decompression in degenerative cervical myelopathy (DCM).

Methods: Twenty-seven patients subjected to French-door laminoplasty underwent the guidance of intraoperative ultrasound (IOUS) and were prospectively included. The modified Japanese Orthopedic Association (mJOA) score was evaluated before surgery and at 12 months postoperatively. The maximum spinal cord compression (MSCC) after sufficient decompression was calculated on the IOUS image; patients were divided into adequate (MSCC ≥ 0.95) and inadequate (MSCC < 0.95) expansion groups according to the MSCC. The mJOA score, spinal cord hyperechogenicity, age at surgery, symptom duration, occupational rate of the spinal canal, and the minimum anteroposterior diameter of the spinal cord between the two groups were compared.

Results: Initially, 2 cases showed residual compression on IOUS; after further decompression, all patients acquired sufficient decompression. All patients achieved improvements in mJOA scores with an average recovery rate of 68.6 ± 20.3%. The recovery rate of the mJOA score of the inadequate expansion group was significantly inferior to that of the adequate expansion group (59.2 ± 21.7% versus 76.2 ± 16.2%, p = 0.028). The spinal cord hyperechogenicity was more common in the inadequate expansion group, while the spinal cord anteroposterior diameter of the inadequate expansion group was significantly smaller than that of the adequate expansion group.

Conclusions: The application of IOUS in French-door laminoplasty could help to confirm sufficient decompression for the treatment of DCM. Inadequate spinal cord expansion after sufficient decompression had the high possibility of predicting less satisfactory neurological recovery of DCM.

Key Points: • The intraoperative ultrasound revealed that not all degenerative cervical myelopathy patients acquired adequate spinal cord expansion after sufficient decompression. • Patients who failed to acquire adequate spinal cord expansion commonly combined with spinal cord hyperechogenicity and trended to achieve less satisfactory neurological recovery after surgical decompression. • Inadequate spinal cord expansion after sufficient decompression had the high possibility of predicting less satisfactory neurological recovery of patients with degenerative cervical myelopathy.
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http://dx.doi.org/10.1007/s00330-021-08000-xDOI Listing
April 2021

Biologically Inspired Scalable-Manufactured Dual-layer Coating with a Hierarchical Micropattern for Highly Efficient Passive Radiative Cooling and Robust Superhydrophobicity.

ACS Appl Mater Interfaces 2021 May 28;13(18):21888-21897. Epub 2021 Apr 28.

Institute for Advanced Ceramics, Harbin Institute of Technology, Harbin 150080, China.

Bioinspired materials for temperature regulation have proven to be promising for passive radiation cooling, and super water repellency is also a main feature of biological evolution. However, the scalable production of artificial passive radiative cooling materials with self-adjusting structures, high-efficiency, strong applicability, and low cost, along with achieving superhydrophobicity simultaneously remains a challenge. Here, a biologically inspired passive radiative cooling dual-layer coating (Bio-PRC) is synthesized by a facile but efficient strategy, after the discovery of long-horned beetles' thermoregulatory behavior with multiscale fluffs, where an adjustable polymer-like layer with a hierarchical micropattern is constructed in various ceramic bottom skeletons, integrating multifunctional components with interlaced "ridge-like" architectures. The Bio-PRC coating reflects above 88% of solar irradiance and demonstrates an infrared emissivity >0.92, which makes the temperature drop by up to 3.6 °C under direct sunlight. Moreover, the hierarchical micro-/nanostructures also endow it with a superhydrophobic surface that has enticing damage resistance, thermal stability, and weatherability. Notably, we demonstrate that the Bio-PRC coatings can be potentially applied in the insulated gate bipolar transistor radiator, for effective temperature conditioning. Meanwhile, the coverage of the dense, super water-repellent top polymer-like layer can prevent the transport of corrosive liquids, ions, and electron transition, illustrating the excellent interdisciplinary applicability of our coatings. This work paves a new way to design next-generation thermal regulation coatings with great potential for applications.
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http://dx.doi.org/10.1021/acsami.1c05651DOI Listing
May 2021

Development and validation of a nomogram predicting the risk of recurrent lumbar disk herniation within 6 months after percutaneous endoscopic lumbar discectomy.

J Orthop Surg Res 2021 Apr 21;16(1):274. Epub 2021 Apr 21.

Department of Orthopedics (Spine Surgery), The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.

Objective: To develop and validate a nomogram useful in predicting recurrent lumbar disk herniation (rLDH) within 6 months after percutaneous endoscopic lumbar discectomy (PELD).

Methods: Information on patients' lumbar disk herniation (LDH) between January 2018 and May 2019 in addition to 26 other features was collected from the authors' hospital. The least absolute shrinkage and selection operator (LASSO) method was used to select the most important risk factors. Moreover, a nomogram was used to build a prediction model using the risk factors selected from LASSO regression. The concordance index (C-index), the receiver operating characteristic (ROC) curve, and calibration curve were used to assess the performance of the model. Finally, clinical usefulness of the nomogram was analyzed using the decision curve and bootstrapping used for internal validation.

Results: Totally, 352 LDH patients were included into this study. Thirty-two patients had recurrence within 6 months while 320 showed no recurrence. Four potential factors, the course of disease, Pfirrmann grade, Modic change, and migration grade, were selected according to the LASSO regression model. Additionally, the C-index of the prediction nomogram was 0.813 (95% CI, 0.726-0.900) and the area under receiver operating characteristic curve (AUC) value was 0.798 while the interval bootstrapping validation C-index was 0.743. Hence, the nomogram might be a good predictive model.

Conclusion: Each variable, the course of disease, Pfirrmann grade, Modic change, and migration grade in the nomogram had a quantitatively corresponding risk score, which can be used in predicting the overall recurrence rate of rLDH within 6 months.
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http://dx.doi.org/10.1186/s13018-021-02425-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8059294PMC
April 2021

Observer-Based Event-Triggered Adaptive Fuzzy Control for Unmeasured Stochastic Nonlinear Systems With Unknown Control Directions.

IEEE Trans Cybern 2021 Apr 20;PP. Epub 2021 Apr 20.

The issue of adaptive output-feedback stabilization is investigated for a category of stochastic nonstrict-feedback nonlinear systems subject to unmeasured state and unknown control directions. By combining the event-triggered mechanism and backstepping technology, an adaptive fuzzy output-feedback controller is devised. In order to make the controller design feasible, a linear state transformation is introduced into the initial system. At the same time, the Nussbaum function technology is used to overcome the difficulties caused by unknown control directions, and the state observer solves the problem of the unmeasured state. Based on the fuzzy-logic system and its structural characteristics, the issue of unknown nonlinear function with nonstrict-feedback structure in the system is tackled. The designed controller could not only guarantee all signals of closed-loop systems are bounded in probability but also save communication resources effectively. Finally, numerical simulation and ship dynamics example are given to confirm the effectiveness of the proposed method.
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http://dx.doi.org/10.1109/TCYB.2021.3069853DOI Listing
April 2021

Robust Sampled-Data Control for Switched Complex Dynamical Networks With Actuators Saturation.

IEEE Trans Cybern 2021 Apr 20;PP. Epub 2021 Apr 20.

In this article, an aperiodic sampled-data control problem is investigated for polytopic uncertain switched complex dynamical networks subject to actuator saturation. Due to the constraint on the upper bound of the sampling interval being no greater than the dwell time, the issue concerning the asynchronization between the sampled-data controller mode and the system mode is hence considered to be caused by subsystems that may switch in a sampling interval. By considering the sampling interval without switching and the sampling interval with switching, the parameters-dependent loop-based Lyapunov functionals are constructed, respectively. With the help of the constructed functional, mean-square exponential stability criteria for the error polytopic uncertain switched complex dynamical networks are presented under the definition of average dwell time. Furthermore, based on the stability criteria, the asynchronous aperiodic sampled-data controller is designed for polytopic uncertain switched complex dynamical networks subject to actuator saturation. The polytopic uncertain switched complex dynamical networks can be guaranteed to exponentially synchronize with the target node based on the proposed stability conditions and aperiodic sampled-data controller design method. Finally, by transforming the proposed theoretical conditions into the LMI-based objective optimization problem, the domain of attraction of polytopic uncertain switched complex dynamical networks is estimated. An example based on switched Chua's circuit is applied to verify the effectiveness of the proposed method.
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http://dx.doi.org/10.1109/TCYB.2021.3069813DOI Listing
April 2021

Influence of Rahnella aquatilis on arsenic accumulation by Vallisneria natans (Lour.) Hara for the phytoremediation of arsenic-contaminated water.

Environ Sci Pollut Res Int 2021 Apr 13. Epub 2021 Apr 13.

Hunan Province Key Laboratory of Coal Resources Clean-utilization and Mine Environment Protection, Hunan University of Science and Technology, Xiangtan, 411201, People's Republic of China.

Vallisneria natans (Lour.) Hara is a suitable submerged plant for the phytoremediation of As-contaminated water. Rahnella aquatilis is one of the plant growth-promoting rhizobacteria. Influences of R. aquatilis on the arsenic accumulation and detoxification of V. natans were investigated. The results showed that As accumulation by V. natans could be significantly improved after R. aquatilis inoculated at the lower level of As (< 2 mg/L). At 0.5, 1, and 2 mg/L As levels, the As concentrations of V. natans with R. aquatilis were respectively 100.40%, 57.96%, and 22.62% higher than that of V. natans with no R. aquatilis. The concentration of As in V. natans was increased with the increasing the As concentration up to 1 mg/L, but it was decreased at 2 mg/L As. The correlation analysis showed that the As accumulated in the plant was positive correlated (R = 0.977, p < 0.01) with indole-3-acetic acid (IAA) produced by R. aquatilis under different As levels. IAA may be the major factor affecting the As accumulation of V. natans. The results of malondialdehyde and superoxide dismutase, hydrogen peroxidase, and ascorbate peroxidase indicated that IAA produced by R. aquatilis had alleviated the arsenic stress on V. natans. The synthesis of IAA by R. aquatilis was related to the As levels. When the As was at 2 mg/L, the IAA that produced by R. aquatilis decreased and the promotion of R. aquatilis on As accumulation by V. natans reduced. However, R. aquatilis has a positive influence on the arsenic accumulation by V. natans at the lower As levels (< 2 mg/L), and it may be a potentially useful way to improve the removal of arsenic from contaminated water using submerged plants.
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http://dx.doi.org/10.1007/s11356-021-13868-9DOI Listing
April 2021

Lignin-Based Phenolic Foam Reinforced by Poplar Fiber and Isocyanate-Terminated Polyurethane Prepolymer.

Polymers (Basel) 2021 Mar 28;13(7). Epub 2021 Mar 28.

Key Laboratory of Wood-Based Materials Science and Utilization, Beijing Forestry University, No. 35 Tsinghua East Road, Haidian District, Beijing 100083, China.

Phenolic foams (PFs) are lightweight (<200 kg/m), high-quality, and inexpensive thermal insulation materials whose heat and fire resistance are much better than those of foam plastics such as polyurethane and polystyrene. They are especially suitable for use as insulation in chemical, petroleum, construction, and other fields that are prone to fires. However, PFs have poor mechanical properties, poor abrasion resistance, and easy pulverization. In this paper, a polyurethane prepolymer was treated with an isocyanate, and then the isocyanate-terminated polyurethane prepolymer and poplar powder were used to prepare modified lignin-based phenolic foams (PUPFs), which improved the abrasion resistance and decreased the pulverization of the foam. The foam composites were comprehensively evaluated by characterizing their chemical structures, surface morphologies, mechanical properties, thermal conductivities, and flame-retardant properties. The pulverization ratio was reduced by 43.5%, and the thermal insulation performance and flame-retardancy (LOI) were improved. Compared with other methods to obtain lignin-based phenolic foam composites with anti-pulverization and flame-retardant properties, the hybrid reinforcement of foam composites with an isocyanate-terminated polyurethane prepolymer and poplar powder offers a novel strategy for an environmentally friendly alternative to the use of woody fibers.
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http://dx.doi.org/10.3390/polym13071068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8036971PMC
March 2021

Intensity of Intraoperative Spinal Cord Hyperechogenicity as a Novel Potential Predictive Indicator of Neurological Recovery for Degenerative Cervical Myelopathy.

Korean J Radiol 2021 Mar 9. Epub 2021 Mar 9.

Guangdong Provincial Key Laboratory of Orthopaedics and Traumatology/Orthopaedic Research Institute, Department of Spine Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Objective: To analyze the correlations between intraoperative ultrasound and MRI metrics of the spinal cord in degenerative cervical myelopathy and identify novel potential predictive ultrasonic indicators of neurological recovery for degenerative cervical myelopathy.

Materials And Methods: Twenty-two patients who underwent French-door laminoplasty for multilevel degenerative cervical myelopathy were followed up for 12 months. The Japanese Orthopedic Association (JOA) scores were assessed preoperatively and 12 months postoperatively. Maximum spinal cord compression and compression rates were measured and calculated using both intraoperative ultrasound imaging and preoperative T2-weight (T2W) MRI. Signal change rates of the spinal cord on preoperative T2W MRI and gray value ratios of dorsal and ventral spinal cord hyperechogenicity on intraoperative ultrasound imaging were measured and calculated. Correlations between intraoperative ultrasound metrics, MRI metrics, and the recovery rate JOA scores were analyzed using Spearman correlation analysis.

Results: The postoperative JOA scores improved significantly, with a mean recovery rate of 65.0 ± 20.3% ( < 0.001). No significant correlations were found between the operative ultrasound metrics and MRI metrics. The gray value ratios of the spinal cord hyperechogenicity was negatively correlated with the recovery rate of JOA scores (ρ = -0.638, = 0.001), while the ventral and dorsal gray value ratios of spinal cord hyperechogenicity were negatively correlated with the recovery rate of JOA-motor scores (ρ = -0.582, = 0.004) and JOA-sensory scores (ρ = -0.452, = 0.035), respectively. The dorsal gray value ratio was significantly higher than the ventral gray value ratio ( < 0.001), while the recovery rate of JOA-motor scores was better than that of JOA-sensory scores at 12 months post-surgery ( = 0.028).

Conclusion: For degenerative cervical myelopathy, the correlations between intraoperative ultrasound and preoperative T2W MRI metrics were not significant. Gray value ratios of the spinal cord hyperechogenicity and dorsal and ventral spinal cord hyperechogenicity were significantly correlated with neurological recovery at 12 months postoperatively.
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http://dx.doi.org/10.3348/kjr.2020.0755DOI Listing
March 2021

Sampled-Data Synchronization of Stochastic Markovian Jump Neural Networks With Time-Varying Delay.

IEEE Trans Neural Netw Learn Syst 2021 Feb 5;PP. Epub 2021 Feb 5.

In this article, sampled-data synchronization problem for stochastic Markovian jump neural networks (SMJNNs) with time-varying delay under aperiodic sampled-data control is considered. By constructing mode-dependent one-sided loop-based Lyapunov functional and mode-dependent two-sided loop-based Lyapunov functional and using the Itô formula, two different stochastic stability criteria are proposed for error SMJNNs with aperiodic sampled data. The slave system can be guaranteed to synchronize with the master system based on the proposed stochastic stability conditions. Furthermore, two corresponding mode-dependent aperiodic sampled-data controllers design methods are presented for error SMJNNs based on these two different stochastic stability criteria, respectively. Finally, two numerical simulation examples are provided to illustrate that the design method of aperiodic sampled-data controller given in this article can effectively stabilize unstable SMJNNs. It is also shown that the mode-dependent two-sided looped-functional method gives less conservative results than the mode-dependent one-sided looped-functional method.
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http://dx.doi.org/10.1109/TNNLS.2021.3054615DOI Listing
February 2021

Parkinson's Disease Classification and Clinical Score Regression via United Embedding and Sparse Learning From Longitudinal Data.

IEEE Trans Neural Netw Learn Syst 2021 Feb 3;PP. Epub 2021 Feb 3.

Parkinson's disease (PD) is known as an irreversible neurodegenerative disease that mainly affects the patient's motor system. Early classification and regression of PD are essential to slow down this degenerative process from its onset. In this article, a novel adaptive unsupervised feature selection approach is proposed by exploiting manifold learning from longitudinal multimodal data. Classification and clinical score prediction are performed jointly to facilitate early PD diagnosis. Specifically, the proposed approach performs united embedding and sparse regression, which can determine the similarity matrices and discriminative features adaptively. Meanwhile, we constrain the similarity matrix among subjects and exploit the l2,p norm to conduct sparse adaptive control for obtaining the intrinsic information of the multimodal data structure. An effective iterative optimization algorithm is proposed to solve this problem. We perform abundant experiments on the Parkinson's Progression Markers Initiative (PPMI) data set to verify the validity of the proposed approach. The results show that our approach boosts the performance on the classification and clinical score regression of longitudinal data and surpasses the state-of-the-art approaches.
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http://dx.doi.org/10.1109/TNNLS.2021.3052652DOI Listing
February 2021

The Correlation Between Facet Tropism and Intervertebral Disc Herniation in the Subaxial Cervical Spine.

Spine (Phila Pa 1976) 2021 Mar;46(5):E310-E317

Department of Orthopedics (Spine Surgery), the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, P.R. China.

Study Design: A retrospective case-control study.

Objective: Investigating the correlation between the facet tropism (FT) and subaxial cervical disc herniation (CDH).

Summary Of Background Data: Although debatable, it was widely reported that FT was associated with lumbar disc herniation. However, the exact correlation between FT and subaxial CDH is still unclear.

Methods: Two-hundred patients with any disc herniation at C3/4, C4/5, C5/6, or C6/7 and 50 normal participants without CDH (normal control group) were included in this study. For patients, the cervical levels with CDH and the levels without herniation were classified into the "herniation group" and "patient control group," respectively. Bilateral facet joint angles at C3/4, C4/5, C5/6, and C6/7 on sagittal, axial, and coronal planes were measured on computed tomography (CT). The disc degeneration at each level was assessed on magnetic resonance imaging (MRI).

Results: Both the mean difference between left and right facet angles and tropism incidence in herniation group were significantly greater than those in two control groups whenever at C3/4, C4/5, C5/6, or C6/7 level and whenever on sagittal, axial, or coronal plane. The mean differences of angles and tropism incidences in most patient control groups were not significantly greater than those of corresponding normal control groups. The incidence of greater facet angle at the left or right side was not significantly different among the left, central, and right herniation groups. The mean disc degeneration grades in both herniation and patient control groups were significantly higher than those in normal control groups while no difference between herniation and patient control groups.

Conclusion: The FT on the sagittal, axial, and coronal planes are all associated with CDH in the subaxial cervical spine. The greater facet angle at the left or right side does not affect the side of herniation. The severity of cervical disc degeneration is not associated with FT.Level of Evidence: 3.
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http://dx.doi.org/10.1097/BRS.0000000000003788DOI Listing
March 2021

Preparation of magnetic hydrochar derived from iron-rich Phytolacca acinosa Roxb. for Cd removal.

Sci Total Environ 2021 May 14;769:145159. Epub 2021 Jan 14.

Hunan Province Key Laboratory of Coal Resources Clean Utilization and Mine Environment Protection, Hunan University of Science and Technology, Xiangtan, Hunan 411201, China; School of Resource Environment and Safety Engineering, Hunan University of Science and Technology, Xiangtan, Hunan 411201, China. Electronic address:

Considering that hyperaccumulators can accumulate high concentrations of iron salt, they can successfully obtain magnetic hydrochar from iron-rich hyperaccumulators. In this study, iron-rich biomass was obtained by irrigating Phytolacca acinosa Roxb. using iron salt. Magnetic nano-FeO hydrochar was prepared from iron-rich Phytolacca acinosa Roxb. via hydrothermal carbonization to remove Cd. The characterization results showed that the synthesized magnetic nanoparticles had an average size of 2.62 ± 0.56 nm and N elements were doped into magnetic nano-FeO hydrochar with abundant oxygenic groups. Cd adsorption on magnetic nano-FeO hydrochar was better fitted using the Langmuir isotherm and the pseudo-second-order kinetic model. The maximum adsorption capacity was 246.6 mg g of Cd. The research confirmed that Cd adsorption was controlled by multiple mechanisms from the jar test, transmission electron microscopy mapping, scanning electron microscopy-energy dispersive X-ray spectroscopy, X-ray diffraction, Fourier transform infrared spectroscopy, and X-ray photoelectron spectroscopy. CdCO crystals can be formed after adsorption, indicating that surface precipitation played an important role in Cd adsorption. The abundance of O atoms and the doping of N atoms on the hydrochar surface were conducive to Cd adsorption, indicating that the mechanisms were related to surface complexation and electrostatic attraction. In addition, the significant decrease in Na content after Cd adsorption illustrated that ion exchange had a non-negligible effect on Cd adsorption. This study not only provides a strategy for preparing magnetic nano-FeO hydrochar derived from iron-rich plants but also verifies multiple Cd adsorption mechanisms using magnetic nano-FeO hydrochar.
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http://dx.doi.org/10.1016/j.scitotenv.2021.145159DOI Listing
May 2021

SET Protein in Cancer: A Potential Therapeutic Target.

Mini Rev Med Chem 2021 Jan 14. Epub 2021 Jan 14.

Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016. China.

SET protein is a multi-functional oncoprotein that is ubiquitously expressed in most tumor cells. Dysregulation of SET has been associated with many types of cancer. Due to ever-accumulating evidence of its strong correlation with both poor prognosis and drug resistance, the targeting of SET is starting to be explored. SET is currently regarded as a potential target for cancer therapy, and several inhibitors are being developed for clinical trials. In this review, the physiological and pathological functions of SET, as well as its antagonists, will be discussed along with the prospects and challenges involved with translating SET inhibitors into bona fide therapeutic options.
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http://dx.doi.org/10.2174/1389557521666210114163318DOI Listing
January 2021

Sialic Acid Conjugate-Modified Liposomal Dexamethasone Palmitate Targeting Neutrophils for Rheumatoid Arthritis Therapy: Influence of Particle Size.

AAPS PharmSciTech 2021 Jan 3;22(1):16. Epub 2021 Jan 3.

Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, Liaoning, China.

Many anti-inflammatory therapies targeting neutrophils have been developed so far. A sialic acid (SA)-modified liposomal (SAL) formulation, based on the high expression of L-selectin in peripheral blood neutrophils (PBNs) and SA as its targeting ligand, has proved to be an effective neutrophil-mediated drug delivery system targeting rheumatoid arthritis (RA). The objective of this study was to investigate the influence of particle size of drug-carrying SALs transported and delivered by neutrophils on their anti-RA effect. Dexamethasone palmitate-loaded SALs (DP-SALs) of different particle sizes (300.2 ± 5.5 nm, 150.3 ± 4.3 nm, and 75.0 ± 3.9 nm) were prepared with DP as a model drug. Our study indicated that DP-SALs could efficiently target PBNs, with larger liposomes leading to higher drug accumulation in cells. However, a high intake of large DP-SALs by PBNs inhibited their migration ability and capacity to release the payload at the target site. In contrast, small DP-SALs (75.0 ± 3.9 nm) could maintain the drug delivery potential of PBNs, leading to their efficient accumulation at the inflammatory site, where PBNs would be excessively activated to form neutrophil extracellular traps along with efficient payload release (small DP-SALs) and finally to induce excellent anti-RA effect.
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http://dx.doi.org/10.1208/s12249-020-01870-2DOI Listing
January 2021

Comparative Five-Year Surgical Outcomes of Open-Door versus French-Door Laminoplasty in Multilevel Cervical Spondylotic Myelopathy.

Biomed Res Int 2020 7;2020:8853733. Epub 2020 Dec 7.

Department of Orthopedic Surgery, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.

Objective: To compare the five-year surgical outcomes between Open-Door laminoplasty (ODL) and French-Door laminoplasty (FDL) in the management of multilevel cervical spondylotic myelopathy (MCSM).

Methods: Sixty patients with MCSM, who were operated by ODL or FDL, were included in this study and followed up for at least 5 years. The average follow-up period was 69.2 ± 3.2 months. The modified Japanese Orthopaedic Association (mJOA) score and radiological assessments including the Cobb angle and cervical range of motion (ROM) were evaluated and compared before surgery and at the final follow-up. The incidence of postoperative complications and medical costs were also compared.

Results: Both ODL and FDL groups achieved significant improvements of the mJOA score in postoperative 5 years; the average recovery rate (RR) of the mJOA score in the ODL and FDL groups was 72.14 ± 6.97% and 69.53 ± 7.51%, respectively. No statistically significant differences regarding the pre- and postoperative mJOA score, the RR of the mJOA score, the loss and the loss rate of the Cobb angle, and the incidence of postoperative complications existed between ODL and FDL. The mean loss and the loss rate of cervical ROM in the FDL group (18.70 ± 8.91°, 41.08 ± 11.17%) were significantly higher than those of the ODL group (13.81 ± 8.62°, 31.47 ± 12.43%) ( < 0.05). FDL reduced medical costs more greatly than ODL (33014.37 ± 3424.12 China Yuan versus 82096.62 ± 7093.07 China Yuan, < 0.001).

Conclusions: Both ODL and FDL are effective for MCSM. The 5-year neurological results are similar between the two groups. ODL trends to be superior to FDL in postoperative preservation of cervical ROM while FDL reduced medical costs more greatly.
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http://dx.doi.org/10.1155/2020/8853733DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7746444PMC
June 2021

Early Clinical Outcomes of Percutaneous Endoscopic Lumbar Discectomy for L4-5 Highly Down-Migrated Disc Herniation: Interlaminar Approach Versus Transforaminal Approach.

World Neurosurg 2021 02 24;146:e413-e418. Epub 2020 Oct 24.

Department of Orthopaedics (Spine Surgery), the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. Electronic address:

Objective: This study is a retrospective evaluation of patients with L4-5 highly down-migrated lumbar disc herniation (LDH) operated with interlaminar endoscopic lumbar discectomy (IELD) versus transforaminal endoscopic lumbar discectomy (TELD).

Methods: From January 2015 to December 2018, 77 patients with L4-5 highly down-migrated LDH were divided into 2 groups according to different surgical approaches. There were 40 patients who underwent IELD, and 37 patients who underwent TELD. The operation time, hospital stay, Oswestry Disability Index, clinical outcome according with modified MacNab criteria, Visual Analog Scale (VAS) scores, and complications were compared between the IELD and TELD groups.

Results: Seventy-seven patients were included, 40 and 37 patients underwent IELD and TELD, respectively. The IELD and TELD groups both achieved a significant improvement in Oswestry Disability Index, back and leg VAS scores, and clinical outcome postoperation. Mean operating and x-ray times during operation were significantly shorter in the IELD group than in the TELD group (41.8 vs. 50.3, 1.8 vs. 13.7). There were 3 patients who experienced recurrence in the IELD group and 2 in the TELD group. In the TELD group, there were 3 patients who required revision surgery due to incompletely removed disc fragment. All patients in the IELD group were treated successfully. There was no other complication in these cases.

Conclusions: Both IELD and TELD could be a good alternative option for highly down-migrated LDH in L4-L5. IELD may have advantages in operation time and x-ray times during operation compared with TELD.
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http://dx.doi.org/10.1016/j.wneu.2020.10.105DOI Listing
February 2021

Comprehensive insights into the occurrence and toxicological issues of nodularins.

Mar Pollut Bull 2021 Jan 9;162:111884. Epub 2020 Dec 9.

Key Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing 400030, China. Electronic address:

The occurrence of cyanobacterial toxins is being increasingly reported. Nodularins (NODs) are one of the cyanotoxins group mainly produced by Nodularia spumigena throughout the world. NODs may exert adverse effects on animal and human health, and NOD-R variant is the most widely investigated. However, research focused on them is still limited. In order to understand the realistic risk well, the aim of this review is to compile the available information in the scientific literature regarding NODs, including their sources, distribution, structural characteristics, physicochemical properties, biosynthesis and degradation, adverse effects in vitro and vivo, and toxicokinetics. More data is urgently needed to integrate the cumulative or synergistic effects of NODs on different species and various cells to better understand, anticipate and aggressively manage their potential toxicity after both short- and long-term exposure in ecosystem, and to minimize or prevent the adverse effects on human health, environment and the economy.
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http://dx.doi.org/10.1016/j.marpolbul.2020.111884DOI Listing
January 2021

A modified cutting line in the single-door cervical laminoplasty via a computed tomography-based morphological study of the subaxial cervical spine.

Clin Neurol Neurosurg 2021 01 23;200:106384. Epub 2020 Nov 23.

Department of Spine Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China. Electronic address:

Objective: To modify the conventional methods of grooving and direction during the single-door cervical laminoplasty (SDCL) in the subaxial cervical spine.

Methods: The distance between the left and the right lamina-lateral mass junction at the upper, middle, and lower levels of each segment (DLL-U, DLL-M, DLL-L), angle between the posterior edge of the vertebral body and the lamina (AVL) and thickness of lamina (TL) were measured in the transverse plane. The parameters of preoperative computed tomography scans of 200 patients who had undergone SDCL were measured. The patients were divided into male and female groups and developmental canal stenosis (DCS) and non-DCS (NDCS) groups.

Results: DLL-M gradually increased from the cranial to the caudal except for C7, and DLL-L > DLL-M > DLL-U in each vertebra. AVL increased from C3 to C7, TL decreased from C3 to C5 and increased from C5 to C7, with both parameters showing no significant differences between the left and right sides. AVL of the DCS group was less than that of the NDCS group (P < 0.01).

Conclusions: In the SDCL, the ideal surgical trough should be several discontinuous lines sloping from top to bottom, rather than a straight line. The abduction angle during drilling should gradually increase from C3 to C7 in the SDCL averaging 40 degrees. This method mentioned above improves the efficiency of the operation with less blood loss as an extended cut into the lateral mass is avoided.
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http://dx.doi.org/10.1016/j.clineuro.2020.106384DOI Listing
January 2021

Ammonia nitrogen sources and pollution along soil profiles in an in-situ leaching rare earth ore.

Environ Pollut 2020 Dec 2;267:115449. Epub 2020 Sep 2.

Institute of Geographic Sciences and Natural Resources Research, Beijing, China; University of Chinese Academy of Sciences, Beijing, China. Electronic address:

The ammonium sulphate ((NH)SO) in-situ leaching process is the most widely used extraction technology for weathered crust elution-deposited rare earth ores (WCED-REOs). Highly concentrated (NH)SO, a representative leaching agent, is often used in the leaching process of WCED-REOs. However, this in-situ leaching process causes nitrogen pollution in the soil, surrounding surface and ground water due to the high concentrations of (NH)SO solutions used as a long term leaching agent. To date, the mechanism behind the variations in ammonia nitrogen (AN) in deep soil profiles is unclear. We conducted vertical and lateral soil sampling and analyzed the collected samples for soil moisture, pH, ammonia forms, and AN contents in soil profiles deeper than 500 cm in an in-situ leaching mining area of Ganzhou, Jiangxi Province, southern China. The results show that primary chemical pollutants in the soil are derived from residual leaching agents with high acidities and concentrations of AN. Twelve years after the mining process was completed, the mean pH values of the tailings in the mining area were 3.90 and 4.87 in its lower reaches. Due to the presence of chemical residues, the AN concentration was 12-40 times higher than that of the raw ore soil before it was mined. The percentages of different ammonium forms in the rare earth tailing soil were 65%, 30%, and 5% for the water-soluble, exchangeable, and fixed ammonium forms, respectively. The results of this study support effective prevention and remediation treatment of environmental problems caused by AN pollution of the soil in WCED-REOs.
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http://dx.doi.org/10.1016/j.envpol.2020.115449DOI Listing
December 2020

Robust Inorganic Daytime Radiative Cooling Coating Based on a Phosphate Geopolymer.

ACS Appl Mater Interfaces 2020 Dec 23;12(49):54963-54971. Epub 2020 Nov 23.

Institute for Advanced Ceramics, Harbin Institute of Technology, Harbin 150080, China.

Daytime radiative cooling can spontaneously cool an object by reflecting sunlight and radiating heat in the form of infrared rays. Current daytime radiative cooling designs, including photonic structures and organic polymer-dielectric systems, are prone to age and fail under harsh conditions including high temperature, mechanical wear, and/or space irradiation. Here, an all-inorganic phosphoric acid-based geopolymer (PGEO) paint was developed and showed robust radiative cooling performance. This versatile suspension paint can be applied directly to diverse surfaces through scalable techniques such as spray coating and brushing. This inorganic coating possesses a high average hemispherical infrared emissivity >0.95 and reflects nearly 90% of solar irradiance. We attributed this excellent spectral selectivity of the PGEO coating to its unique inorganic geopolymer network (-Si-O-Al-O-P-O-), which settled the vibration intensity in a suitable range (0.2 < < 1) and enabled multimode vibration. Moreover, this inorganic coating exhibits good comprehensive performance in terms of heat endurance, mechanical strength, and resistance to intense proton radiation, showing its promising applications in spacecraft, buildings, and communication base stations.
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http://dx.doi.org/10.1021/acsami.0c15799DOI Listing
December 2020

Determination of the Time Window of Event-Related Potential Using Multiple-Set Consensus Clustering.

Front Neurosci 2020 21;14:521595. Epub 2020 Oct 21.

School of Biomedical Engineering, Faculty of Electronic Information and Electrical Engineering, Dalian University of Technology, Dalian, China.

Clustering is a promising tool for grouping the sequence of similar time-points aimed to identify the attention blocks in spatiotemporal event-related potentials (ERPs) analysis. It is most likely to elicit the appropriate time window for ERP of interest if a suitable clustering method is applied to spatiotemporal ERP. However, how to reliably estimate a proper time window from entire individual subjects' data is still challenging. In this study, we developed a novel multiset consensus clustering method in which several clustering results of multiple subjects were combined to retrieve the best fitted clustering for all the subjects within a group. Then, the obtained clustering was processed by a newly proposed time-window detection method to determine the most suitable time window for identifying the ERP of interest in each condition/group. Applying the proposed method to the simulated ERP data and real data indicated that the brain responses from the individual subjects can be collected to determine a reliable time window for different conditions/groups. Our results revealed more precise time windows to identify N2 and P3 components in the simulated data compared to the state-of-the-art methods. Additionally, our proposed method achieved more robust performance and outperformed statistical analysis results in the real data for N300 and prospective positivity components. To conclude, the proposed method successfully estimates the time window for ERP of interest by processing the individual data, offering new venues for spatiotemporal ERP processing.
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http://dx.doi.org/10.3389/fnins.2020.521595DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7610058PMC
October 2020

Molecular role of ethylene in fruit r​ipening of Ziziphus jujube Mill.

Plant Signal Behav 2020 12 24;15(12):1834749. Epub 2020 Oct 24.

College of Life Sciences, Yan'an University , Yan'an, China.

The fruit of Chinese jujube () is widely consumed by human beings due to its high proteins, vitamins, and mineral nutrients. The harvest time of Chinese jujube fruit determines its quality, while ethylene plays a pivotal role in fruit ripening. Nevertheless, the relationship between ethylene biosynthesis/signal transduction and fruit ripening of Chinese jujube is still elusive. Here, the Chinese jujube fruit ripening with its fruit peel color change from cyan to dark red at seven different ripening stages (stage I-VII) and expression levels of genes related to ethylene synthesis and signal transduction were determined. Results showed that expression levels of , and were increasingly upregulated, whereas the expression levels of , and were downregulated from green to red fruit ripening stages. Among them, promoters contain ethylene response element. Taken together, Chinese jujube fruit ripening might be affected by the ethylene signaling which was mainly regulated by , a gene involved in ethylene biosynthesis. This research supports theories and techniques for the storage, preservation and molecular breeding of .
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http://dx.doi.org/10.1080/15592324.2020.1834749DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671070PMC
December 2020

Long-term outcomes in Chinese patients with chronic hepatitis B receiving nucleoside/nucleotide analogue therapy in real-world clinical practice: 5-year results from the EVOLVE study.

Antivir Ther 2020 ;25(6):293-304

Bristol-Myers Squibb, Shanghai, China.

Background: In China, the optimal management of individuals living with chronic HBV infection (CHB) remains an unmet need. The EVOLVE Study was a 5-year prospective, longitudinal, observational study that compared the clinical outcomes in treatment-naive CHB patients receiving entecavir (ETV) or lamivudine (LAM)-based therapies.

Methods: Males or females aged ≥18 years, diagnosed with CHB regardless of cirrhosis or hepatitis B e antigen (HBeAg) status were enrolled from tier 2 city hospitals (between 2012-2014). The choice of initial therapy and subsequent treatment modifications was at the discretion of treating physicians. Key outcomes included treatment modifications, virological response (HBV DNA <300 copies/ml) and HBV disease progression.

Results: Of the 3,408 patients enrolled, 1,807 and 628 received ETV and LAM-based therapy, respectively. The mean age was 39.5 years, 74% were male and 22.9% had cirrhosis. The rate of treatment modification was higher in the LAM-based versus ETV group (25.9% versus 13.7%); viral breakthrough was the most common reason in the LAM-based group versus financial reasons in the ETV group. At week 240, the virological response rate was 73% in both treatment groups. Compared with LAM-based therapy, ETV was associated with a significantly lower incidence of viral breakthrough (12.6% versus 2.1%) and genotypic resistance (10.1% versus 1.2%; P<0.0001 for both); significantly lower risk of HBV disease progression (14.0% versus 10.7%; P=0.0113); and lower rates of progression to decompensated cirrhosis (9.6% versus 6.4%) and hepatocellular carcinoma (1.9% versus 0.8%).

Conclusions: This real-world, longitudinal study demonstrated a significantly lower risk of HBV-related disease progression, viral breakthrough and resistance with ETV versus LAM-based therapy. ClinicalTrials.gov NCT01726439.
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http://dx.doi.org/10.3851/IMP3372DOI Listing
January 2020

Nomogram for predicting kyphotic deformity after laminoplasty in cervical spondylotic myelopathy patients without preoperative kyphotic alignment.

Clin Neurol Neurosurg 2020 12 7;199:106284. Epub 2020 Oct 7.

Department of Spine Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. Electronic address:

Background: Kyphotic deformity occurrence after cervical laminoplasty is not rare. Several studies have emphasized the development of postoperative kyphotic deformity (PKD) will impair the functional outcome of cervical laminoplasty. We established and validated a nomogram prediction model for kyphotic deformity after laminoplasty in cervical spondylotic myelopathy patients (CSM) without preoperative kyphotic alignment.

Methods: Preoperative and 1-year postoperative data of 369 patients who underwent single-door cervical laminoplasty (SDCL) at the author's hospital between July 2010 and February 2018 were collected. Using the least absolute shrinkage and selection operator (LASSO) method, significant parameters were selected to develop a nomogram prediction model. The prognostic performance of the model was evaluated using concordance index (C-index) and calibration curve. The discriminatory ability of the prediction model was evaluated by the area under (receiver operating characteristic) curve (AUC).

Results: Of the 369 patients, 31 developed PKD in 1 year after the surgery. Using the LASSO regression, six significant variables composed the final model: age, C2-7 sagittal vertical axis, C7 slope, C2-7 angle, flexion range of motion and operation level were selected. The AUC of the nomogram was 0.771. The C-index for the prediction nomogram was 0.771 (95 % CI: 0.672-0.870). The calibration curve also indicated good consistency.

Conclusion: A nomogram for predicting PKD after SDCL was established and validated. For patients evaluated by this model with predictive high risk of developing postoperative kyphosis, an alternative approach to the subaxial cervical spine such as anterior surgery should be considered.
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http://dx.doi.org/10.1016/j.clineuro.2020.106284DOI Listing
December 2020

Targeted Drug Delivery to Cancer Stem Cells through Nanotechnological Approaches.

Curr Stem Cell Res Ther 2021 ;16(4):367-384

Key Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning Province, China.

Cancer Stem Cells (CSCs) are responsible for tumor development, invasion and metastasis and resistance to chemotherapy and radiotherapy. Therefore, treatment strategies have turned to targeting CSCs, and utilizing nanotechnological approaches to target CSCs has become increasingly fascinating. Functionalized nanoparticles (NPs), such as metallic NPs, liposomes, polymeric NPs, albumin microspheres and nanomicelles, can easily cross the cytoplasmic membrane and accumulate at their targets to continuously release therapeutic agents in response to the characteristics of the tumor microenvironment. Different kinds of NPs possess different characteristics. Inducing immune responses might be the disadvantage they commonly owned through the summary and analysis of these NPs. For natural polymers, they have many attractive properties, but deficiencies also exist such as poor water-solubility, high viscosity, high permeability, etc. The drug-encapsulated NPs launched in the market and those in the clinical trials exhibit a bright prospect in cancer targeted therapy. In addition, the application of nanodiagnostic techniques, such as nanocantilever and DNA microarray technology and early cancer detection has become an indispensable component in clinical practice to improve in vivo detection and enhance targeting efficiency. This review mainly determines the species and usages of NPs in drug delivery and disease diagnosis, the delivery mechanisms of NPs, the main factors that affect nanomedicine efficiency and toxicity and the further trends in the development of targeted therapy. Nevertheless, more and deeper investigations are still needed to avert potential adverse effects and improve the delivery efficiency to achieve better therapeutic effects.
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http://dx.doi.org/10.2174/1574888X15999201001204727DOI Listing
January 2021

Response inhibition alterations in migraine: evidence from event-related potentials and evoked oscillations.

J Headache Pain 2020 Oct 2;21(1):119. Epub 2020 Oct 2.

Medical School of Chinese PLA, Beijing, China.

Background: Migraine is characterized by a hypersensitivity to environmental stimulation which climaxes during headache attacks but persists during attack-free period. Despite ongoing debates about the nature of the mechanisms giving rise to this abnormality, the presence of deficient inhibitory cortical processes has been proposed to be one possible mechanism underlying its pathogenesis. Empirical evidence supporting this claim is mainly based on previous accounts showing functional cortical disexcitability in the sensory domain. Considering that a general inhibitory control process can play an important role across early to later stage of information processing, this may indicate the important role other dimensions of inhibitory control can play in migraine disability. The present study examined the pathophysiological features of inhibitory control that takes place during suppression of prepotent responses in migraineurs.

Methods: Twenty-two patients with migraine without aura (mean age = 30.86 ± 5.69 years; 19 females) during the interictal period and 25 healthy controls (mean age = 30.24 ± 3.52 years; 18 females) were recruited. We used a stop signal task in combination with event-related potentials (ERPs) to examine participants' neural activity supporting response inhibition.

Results: Behaviorally, migraineurs exhibited prolonged stop signal reaction times relative to healthy controls. At the neural level, the amplitude of the stop-N2 over fronto-central, central and centro-parietal scalp regions, a component of the ERPs related to conflict monitoring during early, non-motoric stages of inhibition, was significantly increased in migraineurs. Meanwhile, the amplitude of the stop-P3 over central and centro-parietal scalp regions, a component of the ERPs reflecting late-stage inhibition of the motor system and cognitive evaluation of motor inhibition, was also significantly increased in migraineurs. Ultimately, our time-frequency analysis further revealed increased delta activity in migraineurs.

Conclusions: Consistent with the theory that alterations in cognitive cortical processes are a key signature of migraine, our findings revealed an abnormal state of suppressing prepotent responses in migraineurs, which can be attributed to cortical disexcitability of the pre-frontal executive network and centro-parietal sensorimotor network. These novel findings extend to show the existence of dysfunctional inhibition control that occurs during suppression of prepotent responses in migraneurs.
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http://dx.doi.org/10.1186/s10194-020-01187-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7531083PMC
October 2020

A Fusion Recognition Method Based on Multifeature Hidden Markov Model for Dynamic Hand Gesture.

Comput Intell Neurosci 2020 9;2020:8871605. Epub 2020 Sep 9.

School of Mechanical and Electronic Engineering, Wuhan University of Technology, Wuhan 430070, Hubei, China.

In this paper, a fusion method based on multiple features and hidden Markov model (HMM) is proposed for recognizing dynamic hand gestures corresponding to an operator's instructions in robot teleoperation. In the first place, a valid dynamic hand gesture from continuously obtained data according to the velocity of the moving hand needs to be separated. Secondly, a feature set is introduced for dynamic hand gesture expression, which includes four sorts of features: palm posture, bending angle, the opening angle of the fingers, and gesture trajectory. Finally, HMM classifiers based on these features are built, and a weighted calculation model fusing the probabilities of four sorts of features is presented. The proposed method is evaluated by recognizing dynamic hand gestures acquired by leap motion (LM), and it reaches recognition rates of about 90.63% for LM-Gesture3D dataset created by the paper and 93.3% for Letter-gesture dataset, respectively.
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http://dx.doi.org/10.1155/2020/8871605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7499330PMC
September 2020