Prof. Guido Iaccarino, MD, PhD - Federico II University of Naples - Full Professor of Applied Medical Science and Technology

Parathyroid Hormone Causes Endothelial Dysfunction by Inducing Mitochondrial ROS and Specific Oxidative Signal Transduction Modifications.

Authors:

Jessica Gambardella Matteo De Rosa Daniela Sorriento Nella Prevete Antonella Fiordelisi Michele Ciccarelli Bruno Trimarco Nicola De Luca Guido Iaccarino

Oxid Med Cell Longev 2018 19;2018:9582319. Epub 2018 Dec 19.

Dept. of Advanced Biomedical Sciences, Federico II University, Napoli, Italy.

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http://dx.doi.org/10.1155/2018/9582319	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313989	PMC

January 2019

21 Reads

A Novel Small Peptide Inhibitor of NFB, RH10, Blocks Oxidative Stress-Dependent Phenotypes in Cancer.

Authors:

Jessica Gambardella Michele Ciccarelli Carmine Del Giudice Antonella Fiordelisi Matteo De Rosa Marina Sala Roberto Pacelli Pietro Campiglia Bruno Trimarco Guido Iaccarino Daniela Sorriento

Oxid Med Cell Longev 2018 4;2018:5801807. Epub 2018 Nov 4.

Department of Advanced Biomedical Sciences, Federico II University, Via Pansini 5, 80131 Naples, Italy.

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http://dx.doi.org/10.1155/2018/5801807	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247396	PMC

January 2019

1 Read

Heart failure and diabetes: metabolic alterations and therapeutic interventions: a state-of-the-art review from the Translational Research Committee of the Heart Failure Association-European Society of Cardiology.

Eur Heart J 2018 Dec;39(48):4243-4254

Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, The Netherlands.

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https://academic.oup.com/eurheartj/advance-article/doi/10.10	Publisher Site
http://dx.doi.org/10.1093/eurheartj/ehy596	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302261	PMC

December 2018

52 Reads

15.203 Impact Factor

GRK2 moderates the acute mitochondrial damage to ionizing radiation exposure by promoting mitochondrial fission/fusion.

Authors:

Antonietta Franco Daniela Sorriento Jessica Gambardella Roberto Pacelli Nella Prevete Claudio Procaccini Giuseppe Matarese Bruno Trimarco Guido Iaccarino Michele Ciccarelli

Cell Death Discov 2018 Dec 14;4:25. Epub 2018 Feb 14.

3Department of Medicine, Surgery and Dentistry, University of Salerno, Baronissi, Italy.

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http://dx.doi.org/10.1038/s41420-018-0028-7	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841414	PMC

December 2018

4 Reads

2 Citations

Rivaroxaban in Patients with Heart Failure, Sinus Rhythm, and Coronary Disease.

Authors:

Faiez Zannad Stefan D Anker William M Byra John G F Cleland Min Fu Mihai Gheorghiade Carolyn S P Lam Mandeep R Mehra James D Neaton Christopher C Nessel Theodore E Spiro Dirk J van Veldhuisen Barry Greenberg

N Engl J Med 2018 10 27;379(14):1332-1342. Epub 2018 Aug 27.

From the Université de Lorraine, INSERM Unité 1116 and Clinical Investigation Center 1433, French Clinical Research Infrastructure Network, Investigation Network Initiative-Cardiovascular and Renal Clinical Trialists, Centre Hospitalier Régional et Universitaire de Nancy, Vandoeuvre lès Nancy, France (F.Z.); the Department of Cardiology and Berlin-Brandenburg Center for Regenerative Therapies, German Center for Cardiovascular Research partner site Berlin, Charité Universitätsmedizin Berlin, Berlin (S.D.A.); Janssen Research and Development, Raritan (W.M.B., C.C.N.), and Bayer U.S., Research and Development, Pharmaceuticals, Thrombosis and Hematology Therapeutic Area, Whippany (T.E.S.) - both in New Jersey; Robertson Centre for Biostatistics and Clinical Trials, University of Glasgow, Glasgow, and the National Heart and Lung Institute, Imperial College London, London - both in the United Kingdom (J.G.F.C.); Janssen Research and Development, Spring House, PA (M.F.); Northwestern University, Chicago (M.G.); National Heart Centre Singapore and Duke-National University of Singapore, Singapore (C.S.P.L.); the Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (C.S.P.L., D.J.V.); Brigham and Women's Hospital and Harvard Medical School, Boston (M.R.M.); the Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis (J.D.N.); and the Department of Medicine, Cardiology Division, University of California, San Diego, San Diego (B.G.).

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http://www.nejm.org/doi/10.1056/NEJMoa1808848	Publisher Site
http://dx.doi.org/10.1056/NEJMoa1808848	DOI Listing

October 2018

28 Reads

55.873 Impact Factor

New Insights in Cardiac Calcium Handling and Excitation-Contraction Coupling.

Authors:

Jessica Gambardella Bruno Trimarco Guido Iaccarino Gaetano Santulli

Adv Exp Med Biol 2018 ;1067:373-385

Department of Advanced Biomedical Sciences, "Federico II" University, Naples, Italy.

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http://dx.doi.org/10.1007/5584_2017_106	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5889357	PMC

October 2018

6 Reads

8 Citations

Tackling frailty and functional decline: Background of the action group A3 of the European innovation partnership for active and healthy ageing.

Maturitas 2018 Sep 20;115:69-73. Epub 2018 Jun 20.

Regional Government Piemonte, Turin, Italy. Electronic address:

Ageing populations represent a challenge to the sustainability of current healthcare systems. The need to balance these demographic changes with gains in healthy life years and quality of life (QoL) constitutes an additional challenge. Aware of this, the European Commission (EC) launched the European Innovation Partnership on Active and Healthy Ageing (EIPonAHA) in 2012. The EIPonAHA is an interdisciplinary and cross-sector initiative involving more than 3000 partners with two specific objectives: to increase the healthy life expectancy of Europeans by two years by 2020, while increasing their QoL. The initiatives of the EIPonAHA have been organized according to six thematic action groups (AGs), with the A3 group targeting areas relating to the prevention of functional decline and frailty. In addition to the good practices of partners, there are several on-going collaborative works. The involvement of the EC includes support through an elaborated research programme in which the Consumers, Health, Agriculture and Food Executive Agency (CHAFEA) and the Directorate-General for Communications Networks, Content and Technology (DG CONNECT) are the main funding bodies. Screening approaches and preventive interventions constitute most of the initiatives within the A3 AG. Partners are distributed across five sub-groups according to good practices: i) cognitive decline, ii) food and nutrition, iii) physical activity, iv) caregivers, and v) frailty and functional decline. Regular updates of the progression of both good practices and collaborative works are presented in A3 AG meetings. The 2017 meeting in Valencia, Spain, showcased in this paper, provides an up-to-date overview of the current status of A3 activities.

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http://dx.doi.org/10.1016/j.maturitas.2018.06.009	DOI Listing

September 2018

16 Reads

2.942 Impact Factor

Difficult-to-control hypertension: identification of clinical predictors and use of ICT-based integrated care to facilitate blood pressure control.

Authors:

Valeria Visco Rosa Finelli Antonietta Valeria Pascale Pietro Mazzeo Nicola Ragosa Valentina Trimarco Maddalena Illario Michele Ciccarelli Guido Iaccarino

J Hum Hypertens 2018 Jul 1;32(7):467-476. Epub 2018 May 1.

Department of Medicine, Surgery and Dentistry, University of Salerno, Salerno, Italy.

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http://dx.doi.org/10.1038/s41371-018-0063-0	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057905	PMC

July 2018

4 Reads

2.700 Impact Factor

Cardiac Nonmyocyte Cell Functions and Crosstalks in Response to Cardiotoxic Drugs.

Authors:

Jessica Gambardella Bruno Trimarco Guido Iaccarino Daniela Sorriento

Oxid Med Cell Longev 2017 22;2017:1089359. Epub 2017 Oct 22.

Dipartimento di Scienze Biomediche Avanzate, Università Federico II di Napoli, via Pansini 5, 80131 Napoli, Italy.

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http://dx.doi.org/10.1155/2017/1089359	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5671742	PMC

July 2018

2 Reads

Exploration into Uric and Cardiovascular Disease: Uric Acid Right for heArt Health (URRAH) Project, A Study Protocol for a Retrospective Observational Study.

Authors:

Giovambattista Desideri Agostino Virdis Edoardo Casiglia Claudio Borghi

High Blood Press Cardiovasc Prev 2018 Jun 9;25(2):197-202. Epub 2018 Feb 9.

Department of Medical and Surgical Science, Alma Mater Studiorum University of Bologna, Bologna, Italy.

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http://dx.doi.org/10.1007/s40292-018-0250-7	DOI Listing

June 2018

1 Read

The Italian version of the quick mild cognitive impairment (Qmci-I) screen: normative study on 307 healthy subjects.

Aging Clin Exp Res 2018 Jun 8. Epub 2018 Jun 8.

Health's Innovation Unit, Campania Region, Naples, Italy.

Objective: To devise an Italian version of the quick mild cognitive impairment screen (Qmci) and to obtain normative data.

Methods: An Italian version of the Qmci screen (Qmci-I) was administered to 307 subjects free from cognitive impairment. The normative sample was divided into three age levels (50-59; 60-69 and 70-80 years) and four education levels (3-5; 6-8; 9-13; >13 years of school attendance). Multiple regression analyses were used to evaluate the effect of age, sex and schooling on Qmci-I scores (overall and by domains) and to calculate cut-off values, with reference to the confidence interval on the fifth centile.

Results: The mean Qmci-I score was 64/100 (SD?=?11). The age variable showed a significant negative effect on the overall Qmci-I score, with older people performing worse than younger ones. Conversely, education was associated with higher scores. Significant effects of age and education affected logical memory alone. For the other domains, the following effects were found: (1) higher age associated with lower scores on delayed recall; (2) higher education levels associated with higher scores on immediate recall, clock drawing and word fluency. The adjusted cut-off score for the Qmci-I screen in this sample was 49.4. Qmci-I scores were weakly correlated with those of MMSE (rho?=?0.20).

Conclusions: The Qmci-I is a rapid and multi-domain short cognitive screening instrument useful for evaluating cognitive functions. However, like other screening tools, it is significantly influenced by age and education, requiring normative data and correction of values when used in the clinical practice.

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http://dx.doi.org/10.1007/s40520-018-0981-2	DOI Listing

June 2018

21 Reads

1.138 Impact Factor

Cardiac eccentric remodeling in patients with rheumatoid arthritis.

Authors:

Valeria Pascale Rosa Finelli Rocco Giannotti Enrico Coscioni Raffaele Izzo Francesco Rozza Dario Caputo Paolo Moscato Guido Iaccarino Michele Ciccarelli

Sci Rep 2018 Apr 12;8(1):5867. Epub 2018 Apr 12.

Department of Medicine, Surgery and Dentistry, University of Salerno, Salerno, Italy.

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http://dx.doi.org/10.1038/s41598-018-24323-0	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5897374	PMC

April 2018

5 Reads

5.080 Impact Factor

The Antioxidant Therapy: New Insights in the Treatment of Hypertension.

Authors:

Daniela Sorriento Nicola De Luca Bruno Trimarco Guido Iaccarino

Front Physiol 2018 21;9:258. Epub 2018 Mar 21.

Dipartimento di Medicina, Chirurgia e Odontoiatria, Università degli Studi di Salerno, Baronissi, Italy.

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http://dx.doi.org/10.3389/fphys.2018.00258	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871811	PMC

March 2018

1 Read

Thyroid function predicts increased cardiovascular risk.

Authors:

Guido Iaccarino Matteo De Rosa Bruno Trimarco

Int J Cardiol 2018 03 28;254:338-339. Epub 2018 Jan 28.

Dept of Advanced Biomedical Sciences, Federico II University of Naples, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2017.11.096	DOI Listing

March 2018

4 Reads

4.040 Impact Factor

The Amino-Terminal Domain of GRK5 Inhibits Cardiac Hypertrophy through the Regulation of Calcium-Calmodulin Dependent Transcription Factors.

Authors:

Daniela Sorriento Gaetano Santulli Michele Ciccarelli Angela Serena Maione Maddalena Illario Bruno Trimarco Guido Iaccarino

Int J Mol Sci 2018 Mar 15;19(3). Epub 2018 Mar 15.

Dipartimento di Medicina, Chirurgia e Odontoiatria "Scuola Medica Salernitana"/DIPMED, Università degli Studi di Salerno, Via S. Allende, 84081 Baronissi (SA), Italy.

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http://dx.doi.org/10.3390/ijms19030861	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877722	PMC

March 2018

8 Reads

1 Citation

2.862 Impact Factor

Diazoxide Improves Mitochondrial Connexin 43 Expression in a Mouse Model of Doxorubicin-Induced Cardiotoxicity.

Authors:

Michela Pecoraro Michele Ciccarelli Antonella Fiordelisi Guido Iaccarino Aldo Pinto Ada Popolo

Int J Mol Sci 2018 Mar 7;19(3). Epub 2018 Mar 7.

Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 84084 Fisciano, Italy.

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http://dx.doi.org/10.3390/ijms19030757	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877618	PMC

March 2018

7 Reads

1 Citation

2.862 Impact Factor

Vitamin D, parathyroid hormone and cardiovascular risk: the good, the bad and the ugly.

Authors:

Antonietta V Pascale Rosa Finelli Rocco Giannotti Valeria Visco Davide Fabbricatore Ida Matula Pietro Mazzeo Nicola Ragosa Angelo Massari Raffaele Izzo Enrico Coscioni Maddalena Illario Michele Ciccarelli Bruno Trimarco Guido Iaccarino

J Cardiovasc Med (Hagerstown) 2018 Feb;19(2):62-66

Department of Medicine, Surgery and Dentistry, University of Salerno, Baronissi.

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http://dx.doi.org/10.2459/JCM.0000000000000614	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5757656	PMC

February 2018

3 Reads

1 Citation

1.410 Impact Factor

The Italian reference sites of the European innovation partnership on active and healthy ageing: Progetto Mattone Internazionale as an enabling factor.

Authors:

Maddalena Illario Vincenzo De Luca Giovanni Tramontano Enrica Menditto Guido Iaccarino Lorenzo Bertorello Ernesto Palummeri Valeria Romano Giuliana Moda Marcello Maggio Mirca Barbolini Lisa Leonardini Antonio Addis

Ann Ist Super Sanita 2017 Jan-Mar;53(1):60-69

Dipartimento di Epidemiologia del Servizio Sanitario Regionale, Regione Lazio, Rome, Italy.

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http://dx.doi.org/10.4415/ANN_17_01_12	DOI Listing

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http://dx.doi.org/10.1038/s41598-017-15283-y	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5696524	PMC

November 2017

11 Reads

4 Citations

5.080 Impact Factor

Impaired mitochondrial calcium uptake caused by tacrolimus underlies beta-cell failure.

Authors:

Angela Lombardi Bruno Trimarco Guido Iaccarino Gaetano Santulli

Cell Commun Signal 2017 Nov 13;15(1):47. Epub 2017 Nov 13.

Department of Medicine, Albert Einstein College of Medicine, New York, NY, USA.

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http://dx.doi.org/10.1186/s12964-017-0203-0	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684747	PMC

November 2017

10 Reads

3 Citations

3.380 Impact Factor

Cardiotoxic Effects of Short-Term Doxorubicin Administration: Involvement of Connexin 43 in Calcium Impairment.

Authors:

Michela Pecoraro Antonio Rodríguez-Sinovas Stefania Marzocco Michele Ciccarelli Guido Iaccarino Aldo Pinto Ada Popolo

Int J Mol Sci 2017 Oct 11;18(10). Epub 2017 Oct 11.

Department of Pharmacy, University of Salerno, Fisciano (SA) 84084, Italy.

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http://dx.doi.org/10.3390/ijms18102121	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666803	PMC

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http://dx.doi.org/10.1007/s11154-017-9417-0	DOI Listing

June 2017

31 Reads

8 Citations

4.892 Impact Factor

The mechanisms of air pollution and particulate matter in cardiovascular diseases.

Authors:

Antonella Fiordelisi Prisco Piscitelli Bruno Trimarco Enrico Coscioni Guido Iaccarino Daniela Sorriento

Heart Fail Rev 2017 05;22(3):337-347

Department of Advanced Biomedical Sciences, University Federico II of Naples, Via Pansini 5, 80131, Naples, Italy.

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http://dx.doi.org/10.1007/s10741-017-9606-7	DOI Listing

May 2017

7 Reads

7 Citations

3.790 Impact Factor

Larger Blood Pressure Reduction by Fixed-Dose Compared to Free Dose Combination Therapy of ACE Inhibitor and Calcium Antagonist in Hypertensive Patients.

Authors:

Valeria Visco Rosa Finelli Antonietta Valeria Pascale Rocco Giannotti Davide Fabbricatore Nicola Ragosa Michele Ciccarelli Guido Iaccarino

Transl Med UniSa 2017 Jan 1;16:17-23. Epub 2017 Jul 1.

Department of Medicine, Surgery and Dentistry, University of Salerno, Italy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536158	PMC

January 2017

3 Reads

1 Citation

Cellular subtype expression and activation of CaMKII regulate the fate of atherosclerotic plaque.

Authors:

Angela Serena Maione Ersilia Cipolletta Daniela Sorriento Francesco Borriello Maria Soprano Maria Rosaria Rusciano Vittoria D'Esposito Abdul Karim Markabaoui Giovanni Domenico De Palma Giovanni Martino Lucio Maresca Giuseppe Nobile Pietro Campiglia Pietro Formisano Michele Ciccarelli Gianni Marone Bruno Trimarco Guido Iaccarino Maddalena Illario

Atherosclerosis 2017 01 5;256:53-61. Epub 2016 Nov 5.

Department of Translational Medical Science, Federico II University, Naples, Italy; Federico II University and Hospital, Naples, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2016.11.006	DOI Listing

January 2017

7 Reads

1 Citation

3.994 Impact Factor

"Freeze, Don't Move": How to Arrest a Suspect in Heart Failure - A Review on Available GRK2 Inhibitors.

Authors:

Daniela Sorriento Michele Ciccarelli Ersilia Cipolletta Bruno Trimarco Guido Iaccarino

Front Cardiovasc Med 2016 6;3:48. Epub 2016 Dec 6.

Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno , Baronissi, SA , Italy.

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http://dx.doi.org/10.3389/fcvm.2016.00048	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5138235	PMC

December 2016

3 Reads

4 Citations

Adrenergic signaling in heart failure and cardiovascular aging.

Authors:

Gaetano Santulli Guido Iaccarino

Maturitas 2016 Nov 26;93:65-72. Epub 2016 Mar 26.

Division of Internal Medicine, Department of Medicine and Surgery, University of Salerno, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.maturitas.2016.03.022	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036981	PMC

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0130477	PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4481531	PMC

March 2016

24 Reads

9 Citations

3.234 Impact Factor

Inflammatory mediators in a short-time mouse model of doxorubicin-induced cardiotoxicity.

Authors:

Michela Pecoraro Mariagiovanna Del Pizzo Stefania Marzocco Rosalinda Sorrentino Michele Ciccarelli Guido Iaccarino Aldo Pinto Ada Popolo

Toxicol Appl Pharmacol 2016 Feb 11;293:44-52. Epub 2016 Jan 11.

Department of Pharmacy, University of Salerno, Fisciano, SA, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.taap.2016.01.006	DOI Listing

February 2016

9 Reads

14 Citations

3.705 Impact Factor

Targeting the CaMKII/ERK interaction in the heart prevents cardiac hypertrophy

PLoS ONE

http://www.scopus.com/inward/record.url?eid=2-s2.0-84938632136&partnerID=MN8TOARS

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2015

1 Read

Active and healthy ageing and independent living

Journal of Aging Research

http://www.scopus.com/inward/record.url?eid=2-s2.0-84939626374&partnerID=MN8TOARS

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2015

1 Read

A novel crosstalk between calcium/calmodulin kinases II and IV regulates cell proliferation in myeloid leukemia cells

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http://dx.doi.org/10.1016/j.jamda.2015.09.004	DOI Listing

December 2015

10 Reads

3 Citations

4.940 Impact Factor

Integrating GRK2 and NFkappaB in the Pathophysiology of Cardiac Hypertrophy

Journal of Cardiovascular Translational Research

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December 2015

1 Read

Prescription Patterns of Antidiabetic Treatment in the Elderly. Results from Southern Italy.

Authors:

V Valentina Orlando F Francesca Guerriero D Putignano Daria V Valeria Marina Monetti M Michele Giuseppe Tari G Giuseppina Farina M Maddalena Illario G Guido Iaccarino E Menditto

Value Health 2015 Nov 20;18(7):A599-600. Epub 2015 Oct 20.

University of Naples Federico II, Naples, Italy.

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http://dx.doi.org/10.1016/j.jval.2015.09.2055	DOI Listing

November 2015

5 Reads

3.280 Impact Factor

Integrating GRK2 and NFkappaB in the Pathophysiology of Cardiac Hypertrophy.

Authors:

Daniela Sorriento Gaetano Santulli Antonietta Franco Ersilia Cipolletta Luigi Napolitano Jessica Gambardella Isabel Gomez-Monterrey Pietro Campiglia Bruno Trimarco Guido Iaccarino Michele Ciccarelli

J Cardiovasc Transl Res 2015 Nov 30;8(8):493-502. Epub 2015 Jul 30.

Department of Medicine and Surgery, University of Salerno, Via Salvador Allende, 84081, Baronissi, SA, Italy.

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http://dx.doi.org/10.1007/s12265-015-9646-0	DOI Listing

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http://dx.doi.org/10.1016/j.cellsig.2014.11.007	DOI Listing

February 2015

15 Reads

4 Citations

4.320 Impact Factor

Human glioblastoma multiforme: p53 reactivation by a novel MDM2 inhibitor.

Authors:

Barbara Costa Sara Bendinelli Pamela Gabelloni Eleonora Da Pozzo Simona Daniele Fabrizio Scatena Renato Vanacore Pietro Campiglia Alessia Bertamino Isabel Gomez-Monterrey Daniela Sorriento Carmine Del Giudice Guido Iaccarino Ettore Novellino Claudia Martini

PLoS One 2013 19;8(8):e72281. Epub 2013 Aug 19.

Department of Pharmacy, University of Pisa, Pisa, Italy.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0072281	PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747081	PMC

January 2015

28 Reads

21 Citations

3.234 Impact Factor

Targeting mitochondria as therapeutic strategy for metabolic disorders.

Authors:

Daniela Sorriento Antonietta Valeria Pascale Rosa Finelli Anna Lisa Carillo Roberto Annunziata Bruno Trimarco Guido Iaccarino

ScientificWorldJournal 2014 13;2014:604685. Epub 2014 Mar 13.

Dipartimento di Medicina e Chirurgia, Università degli Studi di Salerno, Via Salvador Allende, 84081 Baronissi, Italy ; IRCCS Multimedica, Via Fantoli 16/15, 20138 Milano, Italy.

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http://dx.doi.org/10.1155/2014/604685	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976884	PMC

Michele Ciccarelli Maria Rosaria Rusciano Daniela Sorriento Maria Felicia Basilicata Gaetano Santulli Pietro Campiglia Alessia Bertamino Nicola De Luca Bruno Trimarco Guido Iaccarino Maddalena Illario

Cell Signal 2014 Oct 5;26(10):2167-74. Epub 2014 Jul 5.

Department of Translational Science, "Federico II" University of Naples, Italy.

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http://dx.doi.org/10.1016/j.cellsig.2014.06.009	DOI Listing

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http://www.cmcardio.com/upload/092-Tarone-EJHF-2014.pdf	Web Search
http://doi.wiley.com/10.1002/ejhf.62	Publisher Site
http://dx.doi.org/10.1002/ejhf.62	DOI Listing

May 2014

24 Reads

17 Citations

6.530 Impact Factor

ESC Working Group on Myocardial Function Position Paper: how to study the right ventricle in experimental models.

Authors:

Adelino F Leite-Moreira André P Lourenço Jean-Luc Balligand Johann Bauersachs Angela Clerk Leon J De Windt Stephane Heymans Denise Hilfiker-Kleiner Emilio Hirsch Guido Iaccarino Karol A Kaminski Ralph Knöll Manuel Mayr Guido Tarone Thomas Thum Carlo G Tocchetti

Eur J Heart Fail 2014 May 23;16(5):509-18. Epub 2014 Feb 23.

Department of Physiology and Cardiothoracic Surgery, Faculty of Medicine, University of Porto, Al. Prof. Hernani Monteiro, 4200 319, Porto, Portugal.

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http://dx.doi.org/10.1002/ejhf.66	DOI Listing

May 2014

26 Reads

3 Citations

6.530 Impact Factor

Redesigning service delivery for hypertensive patients: a methodological guideline to improve the management of chronic diseases.

Authors:

Adelaide Ippolito Lorella Cannavacciuolo Cristina Ponsiglione Nicola De Luca Guido Iaccarino Maddalena Illario

Transl Med UniSa 2014 Apr 24;9:7-17. Epub 2014 Apr 24.

Research and Development Board, Federico II University Hospital ; ITALY ; Translational Medical Sciences, Federico II University ; ITALY.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012379	PMC

April 2014

8 Reads

SAR study and conformational analysis of a series of novel peptide G protein-coupled receptor kinase 2 inhibitors.

Authors:

Isabel Gomez-Monterrey Alfonso Carotenuto Ersilia Cipolletta Marina Sala Ermelinda Vernieri Antonio Limatola Alessia Bertamino Simona Musella Paolo Grieco Bruno Trimarco Ettore Novellino Guido Iaccarino Pietro Campiglia

Biopolymers 2014 Jan;101(1):121-8

Department of Pharmacy, "Federico II" University of Naples, Naples, Italy.

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http://dx.doi.org/10.1002/bip.22295	DOI Listing

Alfonso Carotenuto Ersilia Cipolletta Isabel Gomez-Monterrey Marina Sala Ermelinda Vernieri Antonio Limatola Alessia Bertamino Simona Musella Daniela Sorriento Paolo Grieco Bruno Trimarco Ettore Novellino Guido Iaccarino Pietro Campiglia

Eur J Med Chem 2013 Nov 13;69:384-92. Epub 2013 Sep 13.

Dipartimento di Farmacia, "Federico II" University of Naples, Italy.

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http://dx.doi.org/10.1016/j.ejmech.2013.08.039	DOI Listing

November 2013

8 Reads

7 Citations

3.450 Impact Factor

Endothelial G protein-coupled receptor kinase 2 regulates vascular homeostasis through the control of free radical oxygen species.

Authors:

Michele Ciccarelli Daniela Sorriento Antonietta Franco Anna Fusco Carmine Del Giudice Roberto Annunziata Ersilia Cipolletta Maria Gaia Monti Gerald W Dorn Bruno Trimarco Guido Iaccarino

Arterioscler Thromb Vasc Biol 2013 Oct 15;33(10):2415-24. Epub 2013 Aug 15.

From the Department of Medicine and Surgery, University of Salerno, Salerno, Italy (M.C., E.C., G.l.); Department of Pharmacology, Center for Translational Medicine, Temple University, Philadelphia, PA (M.C.); Department of Biomedical Sciences, University of Naples Federico II, Naples, Italy (D.S., A.F., C.D.G., R.A., M.G.M., B.T.); Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO (G.W.D.); and IRCCS Multimedica, Milan, Italy (G.I.).

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http://dx.doi.org/10.1161/ATVBAHA.113.302262	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4262246	PMC

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http://dx.doi.org/10.1016/j.ejmech.2012.12.053	DOI Listing

April 2013

7 Reads

4 Citations

3.450 Impact Factor

G-protein-coupled receptor kinase 2 and hypertension: molecular insights and pathophysiological mechanisms.

Authors:

Gaetano Santulli Bruno Trimarco Guido Iaccarino

High Blood Press Cardiovasc Prev 2013 Mar 27;20(1):5-12. Epub 2013 Mar 27.

Department of Advanced Biomedical Sciences, Federico II University of Naples, 80131, Naples, Italy.

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http://dx.doi.org/10.1007/s40292-013-0001-8	DOI Listing

March 2013

5 Reads

46 Citations

Pinpointing beta adrenergic receptor in ageing pathophysiology: victim or executioner? Evidence from crime scenes.

Authors:

Gaetano Santulli Guido Iaccarino

Immun Ageing 2013 Mar 15;10(1):10. Epub 2013 Mar 15.

Departments of Translational Medical Sciences and Advanced Biomedical Sciences, "Federico II" University, Naples, Italy.

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http://dx.doi.org/10.1186/1742-4933-10-10	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763845	PMC

March 2013

20 Reads

26 Citations

2.320 Impact Factor

β2-Adrenergic receptor stimulation improves endothelial progenitor cell-mediated ischemic neoangiogenesis.

Authors:

Gennaro Galasso Roberta De Rosa Michele Ciccarelli Daniela Sorriento Carmine Del Giudice Teresa Strisciuglio Chiara De Biase Rossella Luciano Raffaele Piccolo Adele Pierri Giuseppe Di Gioia Nella Prevete Bruno Trimarco Federico Piscione Guido Iaccarino

Circ Res 2013 Mar 15;112(7):1026-34. Epub 2013 Feb 15.

Department of Medicine and Surgery, University of Salerno, San Giovanni di Dio and Ruggi D'Aragona Academic Hospital, Cardiology Tower, Room S1, Largo Città d'Ippocrate, 84131 Salerno, Italy.

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http://dx.doi.org/10.1161/CIRCRESAHA.111.300152	DOI Listing

March 2013

8 Reads

15 Citations

11.020 Impact Factor

Assessment of the 9p21.3 locus in severity of coronary artery disease in the presence and absence of type 2 diabetes.

BMC Med Genet 2013 Jan 23;14:11. Epub 2013 Jan 23.

IRCCS Multimedica, Via Fantoli 16/15, 20138, Milan, Italy.

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http://dx.doi.org/10.1186/1471-2350-14-11	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3556499	PMC

http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000300800600020&KeyUID=WOS:000300800600020

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2012

1 Read

SOCS1 gene transfer accelerates the transition to heart failure through the inhibition of the gp130/JAK/STAT pathway.

Authors:

Antonio Cittadini Maria Gaia Monti Guido Iaccarino Maria Carmina Castiello Alfonso Baldi Eduardo Bossone Salvatore Longobardi Alberto Maria Marra Valentina Petrillo Lavinia Saldamarco Matthew John During Luigi Saccà Gianluigi Condorelli

Cardiovasc Res 2012 Dec 8;96(3):381-90. Epub 2012 Aug 8.

Department of Clinical Medicine and Cardiovascular and Immunological Sciences, University Federico II, Via Sergio Pansini 5, 80131 Naples, Italy.

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http://dx.doi.org/10.1093/cvr/cvs261	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732068	PMC

December 2012

35 Reads

6 Citations

5.940 Impact Factor

To NFκB or not to NFκB: The Dilemma on How to Inhibit a Cancer Cell Fate Regulator.

Authors:

Daniela Sorriento Maddalena Illario Rosa Finelli Guido Iaccarino

Transl Med UniSa 2012 Sep 11;4:73-85. Epub 2012 Oct 11.

Department of Clinical Medicine, Cardiovascular and Immunological Science, Federico II University of Naples, Italy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3728801	PMC

September 2012

11 Reads

9 Citations

CaMK4 Gene Deletion Induces Hypertension.

Authors:

Gaetano Santulli Ersilia Cipolletta Daniela Sorriento Carmine Del Giudice Antonio Anastasio Sara Monaco Angela Serena Maione Gianluigi Condorelli Annibale Puca Bruno Trimarco Maddalena Illario Guido Iaccarino

J Am Heart Assoc 2012 Aug 24;1(4):e001081. Epub 2012 Aug 24.

Department of Clinical Medicine, Cardiovascular and Immunologic Sciences, "Federico II" University of Naples, Naples, Italy (G.S., E.C., D.S., C.D.G., A.A., B.T.).

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http://dx.doi.org/10.1161/JAHA.112.001081	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3487344	PMC

August 2012

22 Reads

78 Citations

2.882 Impact Factor

Endothelial cells are able to synthesize and release catecholamines both in vitro and in vivo.

Authors:

Daniela Sorriento Gaetano Santulli Carmine Del Giudice Antonio Anastasio Bruno Trimarco Guido Iaccarino

Hypertension 2012 Jul 4;60(1):129-36. Epub 2012 Jun 4.

Department of Medicine and Surgery, Università di Salerno, Via Salvador Allende, 84081 Baronissi, Italy.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.111.189605	DOI Listing

July 2012

26 Reads

23 Citations

6.480 Impact Factor

GRK2 at the control shaft of cellular metabolism.

Authors:

Michele Ciccarelli Ersilia Cipolletta Guido Iaccarino

Curr Pharm Des 2012 ;18(2):121-7

Department of Clinical Medicine and Cardiovascular Science, "Federico II" University of Naples, Italy.

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June 2012

4 Reads

9 Citations

3.452 Impact Factor

Influence of rs5065 atrial natriuretic peptide gene variant on coronary artery disease.

J Am Coll Cardiol 2012 May;59(20):1763-70

Cardiovascular Center Aalst, OLV Clinic, Aalst, Belgium.

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http://dx.doi.org/10.1016/j.jacc.2012.02.017	DOI Listing

May 2012

25 Reads

19 Citations

16.503 Impact Factor

GRK2 levels in umbilical arteries of pregnancies complicated by gestational hypertension and preeclampsia.

Authors:

Raffaele Napolitano Alfonso Campanile Laura Sarno Antonio Anastasio Giuseppe M Maruotti Maddalena Morlando Bruno Trimarco Pasquale Martinelli Guido Iaccarino

Am J Hypertens 2012 Mar;25(3):366-71

Department of Obstetrics and Gynecology, Prenatal Diagnosis and High Risk Pregnancy Unit, University of Naples, Federico II, Naples, Italy.

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http://dx.doi.org/10.1038/ajh.2011.211	DOI Listing

March 2012

6 Reads

2 Citations

2.852 Impact Factor

Age-related impairment in insulin release: the essential role of β(2)-adrenergic receptor.

Authors:

Gaetano Santulli Angela Lombardi Daniela Sorriento Antonio Anastasio Carmine Del Giudice Pietro Formisano Francesco Béguinot Bruno Trimarco Claudia Miele Guido Iaccarino

Diabetes 2012 Mar 7;61(3):692-701. Epub 2012 Feb 7.

Department of Clinical Medicine, Cardiovascular & Immunologic Sciences, Federico II University of Naples, Naples, Italy.

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http://dx.doi.org/10.2337/db11-1027	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282797	PMC

March 2012

16 Reads

38 Citations

8.100 Impact Factor

Mitochondrial localization unveils a novel role for GRK2 in organelle biogenesis.

Authors:

Anna Fusco Gaetano Santulli Daniela Sorriento Ersilia Cipolletta Corrado Garbi Gerald W Dorn Bruno Trimarco Antonio Feliciello Guido Iaccarino

Cell Signal 2012 Feb 1;24(2):468-75. Epub 2011 Oct 1.

Clinical Medicine, Cardiovascular and Immunological Sciences Federico II University, Naples, Italy.

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http://dx.doi.org/10.1016/j.cellsig.2011.09.026	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237777	PMC

February 2012

6 Reads

32 Citations

4.320 Impact Factor

A Polymorphism within the Promoter of the Dopamine Receptor D1 (DRD1 -48A/G) Associates with Impaired Kidney Function in White Hypertensive Patients.

Authors:

Ersilia Cipolletta Michele Ciccarelli Raffaele Izzo Rosa Finelli Bruno Trimarco Guido Iaccarino

Transl Med UniSa 2012 Jan 18;2:10-9. Epub 2012 Jan 18.

Department of Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Federico II University, Naples, Italy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3728780	PMC

Transl Med UniSa 2011 Sep 17;1:213-28. Epub 2011 Oct 17.

Department of Internal Medicine of Federico II University of Naples, Napoli, Italy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3728849	PMC

September 2011

6 Reads

5 Citations

Towards a re-definition of 'cardiac hypertrophy' through a rational characterization of left ventricular phenotypes: a position paper of the Working Group 'Myocardial Function' of the ESC.

Authors:

Ralph Knöll Guido Iaccarino Guido Tarone Denise Hilfiker-Kleiner Johann Bauersachs Adelino F Leite-Moreira Peter H Sugden Jean-Luc Balligand

Eur J Heart Fail 2011 Aug 27;13(8):811-9. Epub 2011 Jun 27.

Myocardial Genetics, British Heart Foundation-Centre for Research Excellence, National Heart & Lung Institute, Imperial College London, Flowers Building, 4th floor, South Kensington Campus, London SW7 2AZ, UK.

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http://dx.doi.org/10.1093/eurjhf/hfr071	DOI Listing

August 2011

26 Reads

11 Citations

6.530 Impact Factor

Association study on long-living individuals from Southern Italy identifies rs10491334 in the CAMKIV gene that regulates survival proteins.

Authors:

Alberto Malovini Maddalena Illario Guido Iaccarino Francesco Villa Anna Ferrario Roberta Roncarati Chiara Viviani Anselmi Valeria Novelli Ersilia Cipolletta Eleonora Leggiero Alessandro Orro Maria Rosaria Rusciano Luciano Milanesi Angela Serena Maione Gianluigi Condorelli Riccardo Bellazzi Annibale A Puca

Rejuvenation Res 2011 Jun 25;14(3):283-91. Epub 2011 May 25.

Dipartimento di Informatica e Sistemistica, Università degli Studi di Pavia, Pavia, Italy.

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http://dx.doi.org/10.1089/rej.2010.1114	DOI Listing

June 2011

46 Reads

32 Citations

3.311 Impact Factor

G protein-coupled receptor kinase 2 activity impairs cardiac glucose uptake and promotes insulin resistance after myocardial ischemia.

Authors:

Michele Ciccarelli J Kurt Chuprun Giuseppe Rengo Erhe Gao Zhengyu Wei Raymond J Peroutka Jessica I Gold Anna Gumpert Mai Chen Nicholas J Otis Gerald W Dorn Bruno Trimarco Guido Iaccarino Walter J Koch

Circulation 2011 May 25;123(18):1953-62. Epub 2011 Apr 25.

George Zallie and Family Laboratory for Cardiovascular Gene Therapy, Center for Translational Medicine, Thomas Jefferson University, Philadelphia, PA, USA.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.110.988642	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3113597	PMC

May 2011

16 Reads

45 Citations

14.430 Impact Factor

G protein-coupled receptor kinase 2 in patients with acute myocardial infarction.

Authors:

Gaetano Santulli Alfonso Campanile Letizia Spinelli Emiliano Assante di Panzillo Michele Ciccarelli Bruno Trimarco Guido Iaccarino

Am J Cardiol 2011 Apr 4;107(8):1125-30. Epub 2011 Feb 4.

Division of Internal Medicine, Department of Clinical Medicine and Cardiovascular and Immunologic Sciences, Federico II University, Naples, Italy.

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http://dx.doi.org/10.1016/j.amjcard.2010.12.006	DOI Listing

April 2011

6 Reads

28 Citations

3.280 Impact Factor

Integrating cardiac PIP3 and cAMP signaling through a PKA anchoring function of p110γ.

Mol Cell 2011 Apr;42(1):84-95

Department of Genetics, Biology and Biochemistry, Molecular Biotechnology Center, University of Torino, Torino 10126, Italy.

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http://dx.doi.org/10.1016/j.molcel.2011.01.030	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265115	PMC

April 2011

26 Reads

56 Citations

14.020 Impact Factor

Impaired neoangiogenesis in β₂-adrenoceptor gene-deficient mice: restoration by intravascular human β₂-adrenoceptor gene transfer and role of NFκB and CREB transcription factors.

Authors:

Michele Ciccarelli Daniela Sorriento Ersilia Cipolletta Gaetano Santulli Anna Fusco Rui-Hai Zhou Andrea D Eckhart Karsten Peppel Walter J Koch Bruno Trimarco Guido Iaccarino

Br J Pharmacol 2011 Feb;162(3):712-21

Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Università Federico II, Napoli, Italy.

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http://dx.doi.org/10.1111/j.1476-5381.2010.01078.x	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3041259	PMC

February 2011

14 Reads

19 Citations

4.842 Impact Factor

Evaluation of the anti-angiogenic properties of the new selective αVβ3 integrin antagonist RGDechiHCit.

Authors:

Gaetano Santulli Maria Felicia Basilicata Mariarosaria De Simone Carmine Del Giudice Antonio Anastasio Daniela Sorriento Michele Saviano Annarita Del Gatto Bruno Trimarco Carlo Pedone Laura Zaccaro Guido Iaccarino

J Transl Med 2011 Jan 13;9. Epub 2011 Jan 13.

Department of Clinical Medicine, Cardiovascular & Immunologic Sciences, Federico II University of Naples, Italy.

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http://dx.doi.org/10.1186/1479-5876-9-7	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3027097	PMC

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http://dx.doi.org/10.1093/eurjhf/hfp173	DOI Listing

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http://dx.doi.org/10.2217/bmm.09.50	DOI Listing

October 2009

3 Reads

2.860 Impact Factor

In vivo properties of the proangiogenic peptide QK.

Authors:

Gaetano Santulli Michele Ciccarelli Gianluigi Palumbo Alfonso Campanile Gennaro Galasso Barbara Ziaco Giovanna Giuseppina Altobelli Vincenzo Cimini Federico Piscione Luca Domenico D'Andrea Carlo Pedone Bruno Trimarco Guido Iaccarino

J Transl Med 2009 Jun 8;7:41. Epub 2009 Jun 8.

Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Cattedra di Medicina Interna, Università degli Studi Federico II di Napoli, Italy.

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http://dx.doi.org/10.1186/1479-5876-7-41	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2702279	PMC

June 2009

7 Reads

33 Citations

3.930 Impact Factor

Insufficient control of blood pressure and incident diabetes.

Authors:

Raffaele Izzo Giovanni de Simone Marcello Chinali Guido Iaccarino Valentina Trimarco Francesco Rozza Renata Giudice Bruno Trimarco Nicola De Luca

Diabetes Care 2009 May 17;32(5):845-50. Epub 2009 Feb 17.

Department of Clinical Medicine, Cardiovascular, and Immunological Sciences, Federico II University-Naples, Naples, Italy.

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http://dx.doi.org/10.2337/dc08-1881	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671117	PMC

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http://dx.doi.org/10.1093/cvr/cvm109	DOI Listing

May 2008

16 Reads

29 Citations

5.940 Impact Factor

The PlA1/A2 polymorphism of glycoprotein IIIa and cerebrovascular events in hypertension: Increased risk of ischemic stroke in high-risk patients

Journal of Hypertension

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2007

Prior exercise improves age-dependent vascular endothelial growth factor downregulation and angiogenesis responses to hind-limb ischemia in old rats

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

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2007

Lymphocyte G-protein-coupled receptor kinase-2 is upregulated in patients with Alzheimer's disease

Neuroscience Letters

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2007

Clinical Pharmacology and Therapeutics

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2006

G protein-coupled receptor kinases and hypertension: A review of disease mechanisms

High Blood Pressure and Cardiovascular Prevention

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2006

Adenoviral gene transfer of Akt enhances myocardial contractility and intracellular calcium handling

Gene Therapy

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2006

Beta2-adrenergic receptor polymorphisms and treatment-induced regression of left ventricular hypertrophy in hypertension.

Authors:

Guido Iaccarino Raffaele Izzo Valentina Trimarco Ersilia Cipolletta Francesca Lanni Daniela Sorriento Gianni Luigi Iovino Francesco Rozza Nicola De Luca Ornella Priante Gianfranco Di Renzo Bruno Trimarco

Clin Pharmacol Ther 2006 Dec;80(6):633-45

Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Università Federico II di Napoli, Italy.

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http://dx.doi.org/10.1016/j.clpt.2006.09.006	DOI Listing

Journal of Hypertension

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2004

Authors:

Guido Iaccarino Walter J Koch

Methods Mol Biol 2004 ;237:181-92

Dipartmento di Medicina Clinica, Scienze Cardiovasculari ed Immunologiche, Federico II University, Naples, Italy.

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February 2004

1 Read

2 Citations

Transgenic mice targeting the heart unveil G protein-coupled receptor kinases as therapeutic targets.

Assay and drug development technologies

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2003

Circulation

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2002

Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice

Proceedings of the National Academy of Sciences of the United States of America

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2002

Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice.

Authors:

Gianluigi Condorelli Alessandra Drusco Giorgio Stassi Alfonso Bellacosa Roberta Roncarati Guido Iaccarino Matteo A Russo Yusu Gu Nancy Dalton Clarence Chung Michael V G Latronico Claudio Napoli Junichi Sadoshima Carlo M Croce John Ross

Proc Natl Acad Sci U S A 2002 Sep;99(19):12333-8

Kimmel Cancer Center, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1073/pnas.172376399	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC129445	PMC

September 2002

15 Reads

126 Citations

9.810 Impact Factor

Beta(2)-adrenergic receptor gene delivery to the endothelium corrects impaired adrenergic vasorelaxation in hypertension.

Authors:

Guido Iaccarino Ersilia Cipolletta Antonia Fiorillo Mario Annecchiarico Michele Ciccarelli Vincenzo Cimini Walter J Koch Bruno Trimarco

Circulation 2002 Jul;106(3):349-55

Department of Clinical Medicine, Cardiovascular and Immunological Sciences, Federico II University, Naples, Italy.

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July 2002

2 Reads

21 Citations

14.430 Impact Factor

Role of the sympathetic nervous system in cardiac remodeling in hypertension

Clinical and Experimental Hypertension

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2001

Authors:

G Iaccarino E Barbato E Cipoletta A Fiorillo B Trimarco

Clin Exp Hypertens 2001 Jan-Feb;23(1-2):35-43

Dipartimento di Medicina Clinica e Terapia Cardiovascolare, Università Federico II, Naples, Italy.

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June 2001

1 Citation

1.460 Impact Factor

Alterations in cardiac adrenergic signaling and calcium cycling differentially affect the progression of cardiomyopathy.

Authors:

K Freeman I Lerman E G Kranias T Bohlmeyer M R Bristow R J Lefkowitz G Iaccarino W J Koch L A Leinwand

J Clin Invest 2001 Apr;107(8):967-74

Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309-0347, USA.

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http://dx.doi.org/10.1172/JCI12083	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC199560	PMC

April 2001

1 Read

38 Citations

13.215 Impact Factor

Progression from hypertrophic to dilated cardiomyopathy in mice that express a mutant myosin transgene.

Authors:

K Freeman C Colon-Rivera M C Olsson R L Moore H D Weinberger I L Grupp K L Vikstrom G Iaccarino W J Koch L A Leinwand

Am J Physiol Heart Circ Physiol 2001 Jan;280(1):H151-9

Department of Molecular Cellular and Developmental Biology, University of Colorado, Boulder 80309-0347, Colorado, USA.

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http://dx.doi.org/10.1152/ajpheart.2001.280.1.H151	DOI Listing

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January 1999

8 Citations

6.480 Impact Factor

Targeting the receptor-G(q) interface to inhibit in vivo pressure overload myocardial hypertrophy

Science

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1998

1 Read

Reciprocal in vivo regulation of myocardial G protein-coupled receptor kinase expression by β-adrenergic receptor stimulation and blockade

Circulation

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1998

Myocardial overexpression of GRK3 in transgenic mice: Evidence for in vivo selectivity of GRKs

American Journal of Physiology - Heart and Circulatory Physiology

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1998

Expression of a β-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice

Proceedings of the National Academy of Sciences of the United States of America

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1998

Adenoviral-mediated inhibition of Gβγ signaling limits the hyperplastic response in experimental vein grafts

Surgery

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1998

Myocardial overexpression of GRK3 in transgenic mice: evidence for in vivo selectivity of GRKs.

Authors:

G Iaccarino H A Rockman K F Shotwell E D Tomhave W J Koch

Am J Physiol 1998 Oct;275(4 Pt 2):H1298-306

Department of Surgery, Duke University Medical Center, Durham North Carolina 27704, USA.

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October 1998

3 Reads

15 Citations

Reciprocal in vivo regulation of myocardial G protein-coupled receptor kinase expression by beta-adrenergic receptor stimulation and blockade.

Authors:

G Iaccarino E D Tomhave R J Lefkowitz W J Koch

Circulation 1998 Oct;98(17):1783-9

Departments of Medicine, Surgery and Biochemistry, Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC, USA.

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G Lembo G Iaccarino C Vecchione E Barbato C Morisco F Monti L Parrella B Trimarco

Hypertension 1997 Nov;30(5):1128-34

IRCCS Neuromed, Pozzilli (IS), Italy.

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November 1997

8 Citations

6.480 Impact Factor

Insulin modulation of an endothelial nitric oxide component present in the alpha2- and beta-adrenergic responses in human forearm.

Authors:

G Lembo G Iaccarino C Vecchione E Barbato R Izzo D Fontana B Trimarco

J Clin Invest 1997 Oct;100(8):2007-14

IRCCS "INM NEUROMED," Pozzilli (IS), Italy.

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http://dx.doi.org/10.1172/JCI119732	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC508390	PMC

October 1997

3 Reads

11 Citations

13.215 Impact Factor

The crosstalk between insulin and the sympathetic nervous system: possible implications in the pathogenesis of essential hypertension.

Authors:

G Lembo C Vecchione G Iaccarino B Trimarco

Blood Press Suppl 1996 ;1:38-42

Istituto Neurologico Mediterraneo "Neuromed", Pozzilli, Italy.

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J Clin Invest 1996 Jul;98(2):256-61

Department of Experimental Medicine and Pathology, "La Sapienza" University, Rome, Italy.

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http://dx.doi.org/10.1172/JCI118787	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC507425	PMC

July 1996

4 Citations

13.215 Impact Factor

Macula study with standardized echography.

Authors:

G Cennamo N Rosa G Iaccarino A La Rana A Pasquariello

Acta Ophthalmol Scand 1996 Apr;74(2):178-81

Department of Ophthalmology, University of Naples-Federico II, Italy.

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April 1996

3 Reads

1 Citation

Insulin modulation of beta-adrenergic vasodilator pathway in human forearm.

Authors:

G Lembo G Iaccarino C Vecchione V Rendina L Parrella B Trimarco

Circulation 1996 Apr;93(7):1403-10

Istituto Neurologico Mediterraneo, Neuromed, Pozzilli, Italy.

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April 1996

3 Reads

2 Citations

14.430 Impact Factor

Influence of digitalis on left ventricular functional response to exercise in congestive heart failure.

Authors:

C Morisco A Cuocolo M Romano A Nappi G Iaccarino M Volpe M Salvatore B Trimarco

Am J Cardiol 1996 Mar;77(7):480-5

Department of Internal Medicine, Federico II University, Naples, Italy.

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March 1996

1 Citation

3.280 Impact Factor

Effects of tissue factor induced by oxygen free radicals on coronary flow during reperfusion.

Authors:

P Golino M Ragni P Cirillo V E Avvedimento A Feliciello N Esposito A Scognamiglio B Trimarco G Iaccarino M Condorelli M Chiariello G Ambrosio

Nat Med 1996 Jan;2(1):35-40

Department of Internal Medicine, Second School of Medicine, University of Naples, Italy.

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January 1996

1 Read

14 Citations

27.363 Impact Factor

Insulin modulation of vascular reactivity is already impaired in prehypertensive spontaneously hypertensive rats

Hypertension

http://www.scopus.com/inward/record.url?eid=2-s2.0-0029116806&partnerID=MN8TOARS

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1995

Insulin modulation of vascular reactivity is already impaired in prehypertensive spontaneously hypertensive rats.

Authors:

G Lembo G Iaccarino C Vecchione V Rendina B Trimarco

Hypertension 1995 Aug;26(2):290-3

IRCCS Sanatrix, Pozzilli, Italy.

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August 1995

4 Citations

6.480 Impact Factor

Trandolapril in patients with essential hypertension: Effects on vascular and cardiac structural changes

Journal of Cardiovascular Pharmacology

http://www.scopus.com/inward/record.url?eid=2-s2.0-0028326073&partnerID=MN8TOARS

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1994

Non-hemodynamic mechanisms of cardiovascular risk in the hypertensive patient: insulin resistance | Rischio cardiovascolare nel paziente iperteso, i meccanismi non emodinamici: l'insulino-resistenza.

Cardiologia

http://www.scopus.com/inward/record.url?eid=2-s2.0-0028715887&partnerID=MN8TOARS

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1994

Insulin blunts sympathetic vasoconstriction through the α2-adrenergic pathway in humans

Hypertension

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1994

Acute noradrenergic activation induces insulin resistance in human skeletal muscle

American Journal of Physiology - Endocrinology and Metabolism

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1994

[Non-hemodynamic mechanisms of cardiovascular risk in the hypertensive patient: insulin resistance].

Authors:

V Rendina G Iaccarino G Iovino C Morisco C Vecchione B Trimarco

Cardiologia 1994 Dec;39(12 Suppl 1):295-8

I Clinica Medica, Università degli Studi, Federico II, Napoli.

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December 1994

Insulin blunts sympathetic vasoconstriction through the alpha 2-adrenergic pathway in humans.

Authors:

G Lembo G Iaccarino V Rendina M Volpe B Trimarco

Hypertension 1994 Oct;24(4):429-38

Department of Internal Medicine, School of Medicine, Federico II University, Naples, Italy.

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October 1994

7 Citations

6.480 Impact Factor

Trandolapril in patients with essential hypertension: effects on vascular and cardiac structural changes.

Authors:

V Rendina G Iaccarino R Russo J Enea R Marchegiano G Lembo B Trimarco

J Cardiovasc Pharmacol 1994 ;23 Suppl 1:S20-4

Department of Internal Medicine, School of Medicine, Federico II University, Naples, Italy.

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September 1994

2.135 Impact Factor

Acute noradrenergic activation induces insulin resistance in human skeletal muscle.

Authors:

G Lembo B Capaldo V Rendina G Iaccarino R Napoli R Guida B Trimarco L Saccá

Am J Physiol 1994 Feb;266(2 Pt 1):E242-7

Department of Internal Medicine, School of Medicine, Federico II University, Naples, Italy.

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http://dx.doi.org/10.1152/ajpendo.1994.266.2.E242	DOI Listing

February 1994

21 Citations

Insulin reduces reflex forearm sympathetic vasoconstriction in healthy humans

Hypertension

http://www.scopus.com/inward/record.url?eid=2-s2.0-0027255940&partnerID=MN8TOARS

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1993

Insulin does not modulate reflex forearm sympathetic vasoconstriction in patients with essential hypertension

Journal of Hypertension

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1993

Digitalis restores the forearm sympathetic response to cardiopulmonary receptor unloading in hypertensive patients with left ventricular hypertrophy

Journal of Hypertension

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1993

Insulin does not modulate reflex forearm sympathetic vasoconstriction in patients with essential hypertension.

Authors:

G Lembo V Rendina G Iaccarino F Lamenza G Condorelli G Rosiello B Trimarco

J Hypertens Suppl 1993 Dec;11(5):S272-3

Department of Internal Medicine, Federico II University, Naples, Italy.

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December 1993

Digitalis restores the forearm sympathetic response to cardiopulmonary receptor unloading in hypertensive patients with left ventricular hypertrophy.

Authors:

G Lembo V Rendina G Iaccarino N De Luca B Ricciardelli M Volpe B Trimarco

J Hypertens 1993 Dec;11(12):1395-402

Department of Internal Medicine, School of Medicine, Federico II University, Naples, Italy.

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December 1993

4.720 Impact Factor

Insulin reduces reflex forearm sympathetic vasoconstriction in healthy humans.

Authors:

G Lembo V Rendina G Iaccarino F Lamenza M Volpe B Trimarco

Hypertension 1993 Jun;21(6 Pt 2):1015-9

Institute of Internal Medicine, School of Medicine, Federico II University, Napoli, Italy.

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June 1993

3 Citations

6.480 Impact Factor

Abnormal sympathetic overactivity evoked by insulin in the skeletal muscle of patients with essential hypertension

Journal of Clinical Investigation

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1992

Abnormal sympathetic overactivity evoked by insulin in the skeletal muscle of patients with essential hypertension.

Authors:

G Lembo R Napoli B Capaldo V Rendina G Iaccarino M Volpe B Trimarco L Saccà

J Clin Invest 1992 Jul;90(1):24-9

Department of Internal Medicine, II School of Medicine, Federico II University, Napoli, Italy.

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http://dx.doi.org/10.1172/JCI115842	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC443058	PMC

July 1992

25 Citations

13.215 Impact Factor

Prof. Guido Iaccarino