Prof. Guido Iaccarino, MD, PhD - Federico II University of Naples - Full Professor of Applied Medical Science and Technology

Prof. Guido Iaccarino

MD, PhD

Federico II University of Naples

Full Professor of Applied Medical Science and Technology

Napoli, Campania | Italy

Main Specialties: Internal Medicine

Additional Specialties: Cardiology

ORCID logohttps://orcid.org/0000-0002-8997-835X


Top Author

Prof. Guido Iaccarino, MD, PhD - Federico II University of Naples - Full Professor of Applied Medical Science and Technology

Prof. Guido Iaccarino

MD, PhD

Introduction

Guido IACCARINO, MD, PhD, FESC;
Full Professor of Applied Medical Sciences and Technologies
ORCID 0000-0002-8997-835X

Professional Address: Dept of Advanced Biomedical Sciences, Via Pansini 5 Building 2, room 27

Curriculum Studiorum:
7-11-1991 Medical Degree at the "Federico II" University, Napoli, (Summa cum
Laudae)
1991-1995 Residency in Cardiology at the Department of Cardiology and
Cardiovascular Surgery, Federico II University of Naples
24-10-1995 Resident, School of Cardiology, Federico II University, Napoli (Summa
cum Laudae)
5-1996 to 8/1999 Assistant Researcher; Laboratory of Robert J. Lefkowitz, Dept. of Medicine,
Duke University Medical Center in collaboration with Walter J. Koch, Dept.
of Surgery, Duke University Medical Center Major: I studied the regulation of the cardiac
?AR signaling in models of cardiac dysfunction. The focus of the researches was on
the role of G protein coupled receptor kinases in the determinism of cardiac
contractility. Second major: mechanisms of G protein coupled receptor regulation of
vascular smooth muscle cells proliferation in vitro and in vivo.
9-1999/8-2001 Telethon Fellow at the Dipartimento di Medicina Clinica e Scienze
Cardiovascolari ed Immunologiche, Università
14 –3-2001 PhD in Cardiovascular Physiology and Pathology, Tor Vergata University
of Rome, Italy
1-11-2002 Assistant Professor of Internal Medicine,
Department of Medicina Clinica Scienze Cardiovascolari ed Immunologiche,
Federico II University of Naples
1-10-2007 Awarded tenure by the Italian Ministry of University
2-9-2010 Board for Associate Professorship
1-11-2011 Associate Professor of Internal Medicine, University of Salerno
15-12-2013 Board for Full Professor: Major in Cardiology
27-12-2013 Board for Full Professor: Major in Internal Medicine
27/03/2018 Board for Full Professor: Major in Translational Medicine
1.12.2018 Full Professor of Applied Medical Science and Technologies, University Federico II of Naples, Italy


Fellowships and Awards
1996 Abroad Adjournment Fellowship from the Federico II University, Naples,
Italy
1996 Salvatore Campus Fellowship Award of the Italian Society of Hypertension
for researches on high blood pressure.
1997 Joint Fellowship from the Italian National Council of Research and NATO
1998 Fellowship from Italian National Council of Research
1997-1999 American Heart Association, North Carolina Associate Fellowship
1999-2001 Telethon Researcher Fellowship
2000 Federico II University Young Investigator Award
2001 Italian Society of Hypertension Young Investigator Award
2002 “Pfizer Doxazosin Award 2001”
2004 “Pfizer Doxazosin Award 2003”
2010 Fellow of the European Society of Cardiology
2013-2015: EHTel Board of Directors

Grants
Ministero della Salute, 2007,(€ 70.000)
Ministero dell’Università e Ricerca Scientifica, PRIN 2016 (€70.000)
Ministero dell’Università e Ricerca Scientifica, PRIN 2013 (€60.000)
Ministero dell’Università e Ricerca Scientifica, PRIN 2009 (€279.000)
Ministero dell’Università e Ricerca Scientifica, PRIN 2007 (€120.000)
Ministero dell’Università e Ricerca; PRIN 2004 (€ 75,000)
Regione Campania, 2006 (€30000)
Società Italiana Ipertensione Arteriosa 2004 (€ 5,000), 2006 (€5,000)
Pfizer, Doxazosin International Award 2002 (€13000)
Pfizer, Doxazosin International Award 2004 (€13000)
Regione Campania, LR 5 annualità 2003 (€19000), 2005 (€20000)
Regione Campania, ADD Protection: 100.000€
FP7-CIP-ICT Pilot Beyond Silos (306.000€)
Horizon2020 “Proempower” (25000€)
Ministero Salute, Progetto di Rete “Easydom” 1.300.000€
Horizon 202 “Vigour” (100.000€)

Reviewer for the following Journals
American Heart Journal; Atherosclerosis; Circulation; Hypertension; Circulation Research; European
Journal of Heart Failure; British Journal of Pharmacology; Journal of Cardiovascular Pharmacology;
Proceedings of the National Academy of Science, USA; Acta Sinica Pharmacologica, Heart, Nutrition,
Metabolism and Cardiovascular Disease; Journal of Cardiovascular Medicine; Journal of Cardiovascular
Medicine, Naunyn-Scmeiderberg Archives of Pharmacology

Editorial Board
Journal of Cardiovascular Medicine; European Journal of Heart Failure; Frontiers in Cardiovascular Physiology; Translational Medicine @ UNISA

Grant Revision for the following agencies:
Ministero Italiano della Istruzione, Università e Ricerca
Ministero Italiano della Salute della Repubblica Italiana
Società Italiana Ipertensione Arteriosa
United States-Israel Binational Foundation (BSF)
Austrian National Science Foundation
Agencie Nationel de la Recherche, France
European Comission COST Action External Expert

Member of the following societies:
American Heart Association; American Society of Pharmacology and Experimental Therapeutics, European
Society of Cardiology; Heart Failure Association of the European Society of Cardiology; Italian Society of
Cardiology; Società Italiana dell’Ipertensione Arteriosa; Società Italiana di Ecografia Cardiaca;

Board of Scientific Societies
Nucleus member of the Working Group on Myocardial Function of the European Society of Cardiology
Translational Group of the Heart Failure Association

Selected list of Publications, as main Author, out of a total of over 160 papers (H factor: 44)

Journal articles
Patents
20090053696 Biomarker For Heart Failure
20090305994Compounds Modulating Vegf Receptor and Uses Thereof
PCT/IB2009/054660 A fusion protein having antitumor activity

Primary Affiliation: Federico II University of Naples - Napoli, Campania , Italy

Specialties:

Additional Specialties:

Research Interests:


View Prof. Guido Iaccarino’s Resume / CV

Education

Mar 2002
Università degli Studi di Roma Tor Vergata Facoltà di Medicina e Chirurgia
PhD
Mar 2001
Torvergata University
PhD in Cardiology
Nov 1991 - Nov 1995
Università degli Studi di Napoli Federico II
Cardiologist
Medicina Clinica Scienze Cardiovascolari ed Immunologiche
Jul 1991
Federico II University
MD
Medicina Clinica, Scienze Cardiovascolari ed Immunologiche
Jul 1991
Federico II University
MD
Medicina Clinica, Scienze Cardiovascolari ed Immunologiche

Experience

Nov 2002 - Feb 2011
Università degli Studi di Napoli Federico II
Assistant Researcher
Medicina Clinica, Sc. Cardiovascolari ed Immunologhe
Aug 1999
dr Lefkowitz lab, Duke Univ. Durham NC, USA
PostDoc
May 1996 - Jul 1999
Duke University
Research Fellow
Dept of Medicine
Dec 2018
Federico II University
Full Professor
Advanced Biomedical Sciences
Feb 2011
University of Salerno
Associate Professor of Medicine
Medicine, Surgery and ondotoiatrics - Scuola Medica Salernitana

Publications

272Publications

2152Reads

919Profile Views

2105PubMed Central Citations

The Italian version of the quick mild cognitive impairment (Qmci-I) screen: normative study on 307 healthy subjects.

Aging Clin Exp Res 2019 Mar 8;31(3):353-360. Epub 2018 Jun 8.

Health's Innovation Unit, Campania Region, Naples, Italy.

Objective: To devise an Italian version of the quick mild cognitive impairment screen (Qmci) and to obtain normative data.

Methods: An Italian version of the Qmci screen (Qmci-I) was administered to 307 subjects free from cognitive impairment. The normative sample was divided into three age levels (50-59; 60-69 and 70-80 years) and four education levels (3-5; 6-8; 9-13; >13 years of school attendance). Multiple regression analyses were used to evaluate the effect of age, sex and schooling on Qmci-I scores (overall and by domains) and to calculate cut-off values, with reference to the confidence interval on the fifth centile.

Results: The mean Qmci-I score was 64/100 (SD?=?11). The age variable showed a significant negative effect on the overall Qmci-I score, with older people performing worse than younger ones. Conversely, education was associated with higher scores. Significant effects of age and education affected logical memory alone. For the other domains, the following effects were found: (1) higher age associated with lower scores on delayed recall; (2) higher education levels associated with higher scores on immediate recall, clock drawing and word fluency. The adjusted cut-off score for the Qmci-I screen in this sample was 49.4. Qmci-I scores were weakly correlated with those of MMSE (rho?=?0.20).

Conclusions: The Qmci-I is a rapid and multi-domain short cognitive screening instrument useful for evaluating cognitive functions. However, like other screening tools, it is significantly influenced by age and education, requiring normative data and correction of values when used in the clinical practice.

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http://dx.doi.org/10.1007/s40520-018-0981-2DOI Listing
March 2019
37 Reads
1.138 Impact Factor

Rivaroxaban in Patients with Heart Failure, Sinus Rhythm, and Coronary Disease.

N Engl J Med 2018 10 27;379(14):1332-1342. Epub 2018 Aug 27.

From the Université de Lorraine, INSERM Unité 1116 and Clinical Investigation Center 1433, French Clinical Research Infrastructure Network, Investigation Network Initiative-Cardiovascular and Renal Clinical Trialists, Centre Hospitalier Régional et Universitaire de Nancy, Vandoeuvre lès Nancy, France (F.Z.); the Department of Cardiology and Berlin-Brandenburg Center for Regenerative Therapies, German Center for Cardiovascular Research partner site Berlin, Charité Universitätsmedizin Berlin, Berlin (S.D.A.); Janssen Research and Development, Raritan (W.M.B., C.C.N.), and Bayer U.S., Research and Development, Pharmaceuticals, Thrombosis and Hematology Therapeutic Area, Whippany (T.E.S.) - both in New Jersey; Robertson Centre for Biostatistics and Clinical Trials, University of Glasgow, Glasgow, and the National Heart and Lung Institute, Imperial College London, London - both in the United Kingdom (J.G.F.C.); Janssen Research and Development, Spring House, PA (M.F.); Northwestern University, Chicago (M.G.); National Heart Centre Singapore and Duke-National University of Singapore, Singapore (C.S.P.L.); the Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (C.S.P.L., D.J.V.); Brigham and Women's Hospital and Harvard Medical School, Boston (M.R.M.); the Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis (J.D.N.); and the Department of Medicine, Cardiology Division, University of California, San Diego, San Diego (B.G.).

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http://www.nejm.org/doi/10.1056/NEJMoa1808848
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http://dx.doi.org/10.1056/NEJMoa1808848DOI Listing
October 2018
38 Reads
55.873 Impact Factor

New Insights in Cardiac Calcium Handling and Excitation-Contraction Coupling.

Adv Exp Med Biol 2018 ;1067:373-385

Department of Advanced Biomedical Sciences, "Federico II" University, Naples, Italy.

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http://dx.doi.org/10.1007/5584_2017_106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5889357PMC
October 2018
10 Reads
8 Citations

Tackling frailty and functional decline: Background of the action group A3 of the European innovation partnership for active and healthy ageing.

Maturitas 2018 Sep 20;115:69-73. Epub 2018 Jun 20.

Regional Government Piemonte, Turin, Italy. Electronic address:

Ageing populations represent a challenge to the sustainability of current healthcare systems. The need to balance these demographic changes with gains in healthy life years and quality of life (QoL) constitutes an additional challenge. Aware of this, the European Commission (EC) launched the European Innovation Partnership on Active and Healthy Ageing (EIPonAHA) in 2012. The EIPonAHA is an interdisciplinary and cross-sector initiative involving more than 3000 partners with two specific objectives: to increase the healthy life expectancy of Europeans by two years by 2020, while increasing their QoL. The initiatives of the EIPonAHA have been organized according to six thematic action groups (AGs), with the A3 group targeting areas relating to the prevention of functional decline and frailty. In addition to the good practices of partners, there are several on-going collaborative works. The involvement of the EC includes support through an elaborated research programme in which the Consumers, Health, Agriculture and Food Executive Agency (CHAFEA) and the Directorate-General for Communications Networks, Content and Technology (DG CONNECT) are the main funding bodies. Screening approaches and preventive interventions constitute most of the initiatives within the A3 AG. Partners are distributed across five sub-groups according to good practices: i) cognitive decline, ii) food and nutrition, iii) physical activity, iv) caregivers, and v) frailty and functional decline. Regular updates of the progression of both good practices and collaborative works are presented in A3 AG meetings. The 2017 meeting in Valencia, Spain, showcased in this paper, provides an up-to-date overview of the current status of A3 activities.

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http://dx.doi.org/10.1016/j.maturitas.2018.06.009DOI Listing
September 2018
19 Reads
2.942 Impact Factor

Cardiac Nonmyocyte Cell Functions and Crosstalks in Response to Cardiotoxic Drugs.

Oxid Med Cell Longev 2017 22;2017:1089359. Epub 2017 Oct 22.

Dipartimento di Scienze Biomediche Avanzate, Università Federico II di Napoli, via Pansini 5, 80131 Napoli, Italy.

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http://dx.doi.org/10.1155/2017/1089359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5671742PMC
July 2018
5 Reads

Exploration into Uric and Cardiovascular Disease: Uric Acid Right for heArt Health (URRAH) Project, A Study Protocol for a Retrospective Observational Study.

High Blood Press Cardiovasc Prev 2018 Jun 9;25(2):197-202. Epub 2018 Feb 9.

Department of Medical and Surgical Science, Alma Mater Studiorum University of Bologna, Bologna, Italy.

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http://dx.doi.org/10.1007/s40292-018-0250-7DOI Listing
June 2018
5 Reads

Cardiac eccentric remodeling in patients with rheumatoid arthritis.

Sci Rep 2018 Apr 12;8(1):5867. Epub 2018 Apr 12.

Department of Medicine, Surgery and Dentistry, University of Salerno, Salerno, Italy.

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http://dx.doi.org/10.1038/s41598-018-24323-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5897374PMC
April 2018
13 Reads
5.080 Impact Factor

The Antioxidant Therapy: New Insights in the Treatment of Hypertension.

Front Physiol 2018 21;9:258. Epub 2018 Mar 21.

Dipartimento di Medicina, Chirurgia e Odontoiatria, Università degli Studi di Salerno, Baronissi, Italy.

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http://dx.doi.org/10.3389/fphys.2018.00258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871811PMC
March 2018
7 Reads

Diazoxide Improves Mitochondrial Connexin 43 Expression in a Mouse Model of Doxorubicin-Induced Cardiotoxicity.

Int J Mol Sci 2018 Mar 7;19(3). Epub 2018 Mar 7.

Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 84084 Fisciano, Italy.

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http://dx.doi.org/10.3390/ijms19030757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877618PMC
March 2018
13 Reads
1 Citation
2.862 Impact Factor

The Amino-Terminal Domain of GRK5 Inhibits Cardiac Hypertrophy through the Regulation of Calcium-Calmodulin Dependent Transcription Factors.

Int J Mol Sci 2018 Mar 15;19(3). Epub 2018 Mar 15.

Dipartimento di Medicina, Chirurgia e Odontoiatria "Scuola Medica Salernitana"/DIPMED, Università degli Studi di Salerno, Via S. Allende, 84081 Baronissi (SA), Italy.

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http://dx.doi.org/10.3390/ijms19030861DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877722PMC
March 2018
10 Reads
1 Citation
2.862 Impact Factor

Thyroid function predicts increased cardiovascular risk.

Int J Cardiol 2018 03 28;254:338-339. Epub 2018 Jan 28.

Dept of Advanced Biomedical Sciences, Federico II University of Naples, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2017.11.096DOI Listing
March 2018
8 Reads
4.040 Impact Factor

Association Study Between Coronary Artery Disease and rs1333049 Polymorphism at 9p21.3 Locus in Italian Population.

J Cardiovasc Transl Res 2017 Dec 21;10(5-6):455-458. Epub 2017 Jun 21.

Department of Molecular Medicine and Medical Biotechnology, Federico II University, Via G. Salvatore 486, 80145, Naples, Italy.

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http://dx.doi.org/10.1007/s12265-017-9758-9DOI Listing
December 2017
9 Reads
2.691 Impact Factor

Erratum to: Association Study between Coronary Artery Disease and rs1333049 Polymorphism at 9p21.3 Locus in Italian Population.

J Cardiovasc Transl Res 2017 12;10(5-6):459

Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Naples, Italy.

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http://dx.doi.org/10.1007/s12265-017-9762-0DOI Listing
December 2017
11 Reads
2.691 Impact Factor

Impaired mitochondrial calcium uptake caused by tacrolimus underlies beta-cell failure.

Cell Commun Signal 2017 Nov 13;15(1):47. Epub 2017 Nov 13.

Department of Medicine, Albert Einstein College of Medicine, New York, NY, USA.

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http://dx.doi.org/10.1186/s12964-017-0203-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684747PMC
November 2017
14 Reads
3 Citations
3.380 Impact Factor

Sirolimus induces depletion of intracellular calcium stores and mitochondrial dysfunction in pancreatic beta cells.

Sci Rep 2017 Nov 20;7(1):15823. Epub 2017 Nov 20.

Department of Medicine, Albert Einstein College of Medicine, New York, NY, USA.

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http://dx.doi.org/10.1038/s41598-017-15283-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5696524PMC
November 2017
15 Reads
4 Citations
5.080 Impact Factor

Cardiotoxic Effects of Short-Term Doxorubicin Administration: Involvement of Connexin 43 in Calcium Impairment.

Int J Mol Sci 2017 Oct 11;18(10). Epub 2017 Oct 11.

Department of Pharmacy, University of Salerno, Fisciano (SA) 84084, Italy.

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http://dx.doi.org/10.3390/ijms18102121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666803PMC
October 2017
19 Reads
2 Citations
2.862 Impact Factor

Functional Role of Mitochondria in Arrhythmogenesis.

Adv Exp Med Biol 2017 ;982:191-202

Dept. of Biomedical Advanced Sciences, Federico II University, Naples, Italy.

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http://dx.doi.org/10.1007/978-3-319-55330-6_10DOI Listing
September 2017
29 Reads
3 Citations

Vitamin-D concentrations, cardiovascular risk and events - a review of epidemiological evidence.

Rev Endocr Metab Disord 2017 06;18(2):259-272

Department of Medicine, Surgery Odontoiatrics-Scuola Medica Salernitana, University of Salerno, Salerno, Italy.

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http://dx.doi.org/10.1007/s11154-017-9417-0DOI Listing
June 2017
39 Reads
8 Citations
4.892 Impact Factor

The mechanisms of air pollution and particulate matter in cardiovascular diseases.

Heart Fail Rev 2017 05;22(3):337-347

Department of Advanced Biomedical Sciences, University Federico II of Naples, Via Pansini 5, 80131, Naples, Italy.

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http://dx.doi.org/10.1007/s10741-017-9606-7DOI Listing
May 2017
12 Reads
7 Citations
3.790 Impact Factor

Cellular subtype expression and activation of CaMKII regulate the fate of atherosclerotic plaque.

Atherosclerosis 2017 01 5;256:53-61. Epub 2016 Nov 5.

Department of Translational Medical Science, Federico II University, Naples, Italy; Federico II University and Hospital, Naples, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2016.11.006DOI Listing
January 2017
12 Reads
1 Citation
3.994 Impact Factor

"Freeze, Don't Move": How to Arrest a Suspect in Heart Failure - A Review on Available GRK2 Inhibitors.

Front Cardiovasc Med 2016 6;3:48. Epub 2016 Dec 6.

Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno , Baronissi, SA , Italy.

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http://dx.doi.org/10.3389/fcvm.2016.00048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5138235PMC
December 2016
7 Reads
4 Citations

Adrenergic signaling in heart failure and cardiovascular aging.

Maturitas 2016 Nov 26;93:65-72. Epub 2016 Mar 26.

Division of Internal Medicine, Department of Medicine and Surgery, University of Salerno, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.maturitas.2016.03.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036981PMC
November 2016
8 Reads
15 Citations
2.942 Impact Factor

Active and Healthy Ageing and Independent Living 2016.

J Aging Res 2016 12;2016:8062079. Epub 2016 Oct 12.

Department of Computing Science, Umeå University, Umea, Sweden.

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http://dx.doi.org/10.1155/2016/8062079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5080497PMC
October 2016
7 Reads
6 Citations

Prescription Patterns of Antidiabetic Treatment in the Elderly. Results from Southern Italy.

Curr Diabetes Rev 2015 ;12(2):100-6

CIRFF, Center of Pharmacoeconomics, University of Naples Federico II, Via Domenico Montesano 49, 80131 Naples, Italy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384339PMC
September 2016
8 Reads
8 Citations

Good at Heart: Preserving Cardiac Metabolism during aging.

Curr Diabetes Rev 2015 ;12(2):90-9

Department of Medicine and Surgery, University of Salerno, Italy.

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September 2016
9 Reads
1 Citation

Inflammatory mediators in a short-time mouse model of doxorubicin-induced cardiotoxicity.

Toxicol Appl Pharmacol 2016 Feb 11;293:44-52. Epub 2016 Jan 11.

Department of Pharmacy, University of Salerno, Fisciano, SA, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.taap.2016.01.006DOI Listing
February 2016
14 Reads
14 Citations
3.705 Impact Factor

Operational Definition of Active and Healthy Aging (AHA): The European Innovation Partnership (EIP) on AHA Reference Site Questionnaire: Montpellier October 20-21, 2014, Lisbon July 2, 2015.

J Am Med Dir Assoc 2015 Dec 20;16(12):1020-6. Epub 2015 Oct 20.

Department of Health, Social Services and Public Safety, Belfast, Ireland.

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http://dx.doi.org/10.1016/j.jamda.2015.09.004DOI Listing
December 2015
17 Reads
3 Citations
4.940 Impact Factor

Prescription Patterns of Antidiabetic Treatment in the Elderly. Results from Southern Italy.

Value Health 2015 Nov 20;18(7):A599-600. Epub 2015 Oct 20.

University of Naples Federico II, Naples, Italy.

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http://dx.doi.org/10.1016/j.jval.2015.09.2055DOI Listing
November 2015
10 Reads
3.280 Impact Factor

Integrating GRK2 and NFkappaB in the Pathophysiology of Cardiac Hypertrophy.

J Cardiovasc Transl Res 2015 Nov 30;8(8):493-502. Epub 2015 Jul 30.

Department of Medicine and Surgery, University of Salerno, Via Salvador Allende, 84081, Baronissi, SA, Italy.

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http://dx.doi.org/10.1007/s12265-015-9646-0DOI Listing
November 2015
16 Reads
10 Citations
2.691 Impact Factor

Novel therapeutic targets in metabolic disorders: from the bench to the bedside.

ScientificWorldJournal 2014 13;2014:365974. Epub 2014 May 13.

Department of Translational Medical Sciences, University of Naples Federico II, 80131 Naples, Italy.

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http://dx.doi.org/10.1155/2014/365974DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053085PMC
February 2015
12 Reads
1.220 Impact Factor

A novel crosstalk between calcium/calmodulin kinases II and IV regulates cell proliferation in myeloid leukemia cells.

Cell Signal 2015 Feb 15;27(2):204-14. Epub 2014 Nov 15.

Dipartimento di Scienze Mediche Traslazionali, Federico II University, Naples, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.cellsig.2014.11.007DOI Listing
February 2015
22 Reads
4 Citations
4.320 Impact Factor

Targeting mitochondria as therapeutic strategy for metabolic disorders.

ScientificWorldJournal 2014 13;2014:604685. Epub 2014 Mar 13.

Dipartimento di Medicina e Chirurgia, Università degli Studi di Salerno, Via Salvador Allende, 84081 Baronissi, Italy ; IRCCS Multimedica, Via Fantoli 16/15, 20138 Milano, Italy.

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http://dx.doi.org/10.1155/2014/604685DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976884PMC
January 2015
14 Reads
13 Citations
1.220 Impact Factor

CaMKII protects MKP-1 from proteasome degradation in endothelial cells.

Cell Signal 2014 Oct 5;26(10):2167-74. Epub 2014 Jul 5.

Department of Translational Science, "Federico II" University of Naples, Italy.

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http://dx.doi.org/10.1016/j.cellsig.2014.06.009DOI Listing
October 2014
16 Reads
1 Citation
4.320 Impact Factor

Trafficking GRK2: Cellular and Metabolic consequences of GRK2 subcellular localization.

Transl Med UniSa 2014 Sep 8;10:3-7. Epub 2014 Apr 8.

Department of Medicine and Surgery, University of Salerno, Baronissi (SA), Italy; ; IRCCS Multimedica, Milano, Italy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140422PMC
September 2014
10 Reads
7 Citations

Atrial fibrillation and microRNAs.

Front Physiol 2014 24;5:15. Epub 2014 Jan 24.

Humanitas Clinical and Research Center Rozzano (Milan), Italy ; University of Milan Milan, Italy.

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http://dx.doi.org/10.3389/fphys.2014.00015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900852PMC
June 2014
32 Reads
45 Citations

ESC Working Group on Myocardial Function Position Paper: how to study the right ventricle in experimental models.

Eur J Heart Fail 2014 May 23;16(5):509-18. Epub 2014 Feb 23.

Department of Physiology and Cardiothoracic Surgery, Faculty of Medicine, University of Porto, Al. Prof. Hernani Monteiro, 4200 319, Porto, Portugal.

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http://dx.doi.org/10.1002/ejhf.66DOI Listing
May 2014
34 Reads
3 Citations
6.530 Impact Factor

Redesigning service delivery for hypertensive patients: a methodological guideline to improve the management of chronic diseases.

Transl Med UniSa 2014 Apr 24;9:7-17. Epub 2014 Apr 24.

Research and Development Board, Federico II University Hospital ; ITALY ; Translational Medical Sciences, Federico II University ; ITALY.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012379PMC
April 2014
16 Reads

Enhanced expression of β3-adrenoceptors in cardiac myocytes attenuates neurohormone-induced hypertrophic remodeling through nitric oxide synthase.

Circulation 2014 Jan 4;129(4):451-62. Epub 2013 Nov 4.

Institut de Recherche Expérimentale et Clinique (IREC), Pole of Pharmacology and Therapeutics (FATH), Université Catholique de Louvain, Brussels, Belgium (C.B., J. Hammond, E.D.-D., B.M., J. Hamelet, A.M., H.E., K.J., I.L., C.D., J.-L.B.); Pole of Cardiovascular Pathology and Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Brussels, Belgium (C.B., A.-C.P., L.B.); the Division of Cardiology and Pneumology, University of Goettingen, Goettingen, Germany (K.R.G., V.O.N.); the Department of Cardiovascular Sciences, Katholieke Universiteit Leuven, Belgium (A.V., P.H.); the Department of Medicine and Surgery, University of Salerno and RCCS "Multimedica," Milano, Italy (G.I.); Molecular Cardiology, Medizinische Hochschule Hannover, Germany (D.H.-K.); and Université Paul Sabatier, Inserm UMR 1048 - I2MC, Hôpitaux de Toulouse, France (G.T., D.L.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.113.004940DOI Listing
January 2014
46 Reads
26 Citations
14.430 Impact Factor

Design, synthesis and efficacy of novel G protein-coupled receptor kinase 2 inhibitors.

Eur J Med Chem 2013 Nov 13;69:384-92. Epub 2013 Sep 13.

Dipartimento di Farmacia, "Federico II" University of Naples, Italy.

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http://dx.doi.org/10.1016/j.ejmech.2013.08.039DOI Listing
November 2013
11 Reads
7 Citations
3.450 Impact Factor

Endothelial G protein-coupled receptor kinase 2 regulates vascular homeostasis through the control of free radical oxygen species.

Arterioscler Thromb Vasc Biol 2013 Oct 15;33(10):2415-24. Epub 2013 Aug 15.

From the Department of Medicine and Surgery, University of Salerno, Salerno, Italy (M.C., E.C., G.l.); Department of Pharmacology, Center for Translational Medicine, Temple University, Philadelphia, PA (M.C.); Department of Biomedical Sciences, University of Naples Federico II, Naples, Italy (D.S., A.F., C.D.G., R.A., M.G.M., B.T.); Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO (G.W.D.); and IRCCS Multimedica, Milan, Italy (G.I.).

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http://dx.doi.org/10.1161/ATVBAHA.113.302262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4262246PMC
October 2013
26 Reads
11 Citations
6.000 Impact Factor

Adrenergic receptors and metabolism: role in development of cardiovascular disease.

Front Physiol 2013 Oct 3;4:265. Epub 2013 Oct 3.

Department of Medicine and Surgery, University of Salerno Salerno, Italy ; Center for Translational Medicine, Department of Pharmacology, Temple University of Philadelphia PA, USA.

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http://dx.doi.org/10.3389/fphys.2013.00265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789271PMC
October 2013
10 Reads
7 Citations

Physical activity ameliorates cardiovascular health in elderly subjects: the functional role of the β adrenergic system.

Front Physiol 2013 12;4:209. Epub 2013 Aug 12.

Department of Translational Medical Sciences, "Federico II" University Naples, Italy ; Department of Advanced Biomedical Sciences, "Federico II" University Naples, Italy ; College of Physicians and Surgeons, New York Presbyterian Hospital, Columbia University in the City of New York Manhattan, New York, NY, USA.

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http://dx.doi.org/10.3389/fphys.2013.00209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3740240PMC
August 2013
12 Reads
21 Citations

Characterization of a selective CaMKII peptide inhibitor.

Eur J Med Chem 2013 Apr 22;62:425-34. Epub 2013 Jan 22.

Depart. of Pharmaceutical and Toxicological Chemistry, University of Naples Federico II, Naples, Italy.

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http://dx.doi.org/10.1016/j.ejmech.2012.12.053DOI Listing
April 2013
10 Reads
4 Citations
3.450 Impact Factor

G-protein-coupled receptor kinase 2 and hypertension: molecular insights and pathophysiological mechanisms.

High Blood Press Cardiovasc Prev 2013 Mar 27;20(1):5-12. Epub 2013 Mar 27.

Department of Advanced Biomedical Sciences, Federico II University of Naples, 80131, Naples, Italy.

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http://dx.doi.org/10.1007/s40292-013-0001-8DOI Listing
March 2013
10 Reads
46 Citations

β2-Adrenergic receptor stimulation improves endothelial progenitor cell-mediated ischemic neoangiogenesis.

Circ Res 2013 Mar 15;112(7):1026-34. Epub 2013 Feb 15.

Department of Medicine and Surgery, University of Salerno, San Giovanni di Dio and Ruggi D'Aragona Academic Hospital, Cardiology Tower, Room S1, Largo Città d'Ippocrate, 84131 Salerno, Italy.

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http://dx.doi.org/10.1161/CIRCRESAHA.111.300152DOI Listing
March 2013
13 Reads
15 Citations
11.020 Impact Factor

Pinpointing beta adrenergic receptor in ageing pathophysiology: victim or executioner? Evidence from crime scenes.

Immun Ageing 2013 Mar 15;10(1):10. Epub 2013 Mar 15.

Departments of Translational Medical Sciences and Advanced Biomedical Sciences, "Federico II" University, Naples, Italy.

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http://dx.doi.org/10.1186/1742-4933-10-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763845PMC
March 2013
30 Reads
26 Citations
2.320 Impact Factor

SOCS1 gene transfer accelerates the transition to heart failure through the inhibition of the gp130/JAK/STAT pathway.

Cardiovasc Res 2012 Dec 8;96(3):381-90. Epub 2012 Aug 8.

Department of Clinical Medicine and Cardiovascular and Immunological Sciences, University Federico II, Via Sergio Pansini 5, 80131 Naples, Italy.

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http://dx.doi.org/10.1093/cvr/cvs261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732068PMC
December 2012
48 Reads
6 Citations
5.940 Impact Factor

To NFκB or not to NFκB: The Dilemma on How to Inhibit a Cancer Cell Fate Regulator.

Transl Med UniSa 2012 Sep 11;4:73-85. Epub 2012 Oct 11.

Department of Clinical Medicine, Cardiovascular and Immunological Science, Federico II University of Naples, Italy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3728801PMC
September 2012
14 Reads
9 Citations

CaMK4 Gene Deletion Induces Hypertension.

J Am Heart Assoc 2012 Aug 24;1(4):e001081. Epub 2012 Aug 24.

Department of Clinical Medicine, Cardiovascular and Immunologic Sciences, "Federico II" University of Naples, Naples, Italy (G.S., E.C., D.S., C.D.G., A.A., B.T.).

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http://dx.doi.org/10.1161/JAHA.112.001081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3487344PMC
August 2012
34 Reads
78 Citations
2.882 Impact Factor

Endothelial cells are able to synthesize and release catecholamines both in vitro and in vivo.

Hypertension 2012 Jul 4;60(1):129-36. Epub 2012 Jun 4.

Department of Medicine and Surgery, Università di Salerno, Via Salvador Allende, 84081 Baronissi, Italy.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.111.189605DOI Listing
July 2012
34 Reads
23 Citations
6.480 Impact Factor

GRK2 at the control shaft of cellular metabolism.

Curr Pharm Des 2012 ;18(2):121-7

Department of Clinical Medicine and Cardiovascular Science, "Federico II" University of Naples, Italy.

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June 2012
7 Reads
9 Citations
3.452 Impact Factor

GRK2 levels in umbilical arteries of pregnancies complicated by gestational hypertension and preeclampsia.

Am J Hypertens 2012 Mar;25(3):366-71

Department of Obstetrics and Gynecology, Prenatal Diagnosis and High Risk Pregnancy Unit, University of Naples, Federico II, Naples, Italy.

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http://dx.doi.org/10.1038/ajh.2011.211DOI Listing
March 2012
10 Reads
2 Citations
2.852 Impact Factor

Age-related impairment in insulin release: the essential role of β(2)-adrenergic receptor.

Diabetes 2012 Mar 7;61(3):692-701. Epub 2012 Feb 7.

Department of Clinical Medicine, Cardiovascular & Immunologic Sciences, Federico II University of Naples, Naples, Italy.

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http://dx.doi.org/10.2337/db11-1027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282797PMC
March 2012
22 Reads
38 Citations
8.100 Impact Factor

Mitochondrial localization unveils a novel role for GRK2 in organelle biogenesis.

Cell Signal 2012 Feb 1;24(2):468-75. Epub 2011 Oct 1.

Clinical Medicine, Cardiovascular and Immunological Sciences Federico II University, Naples, Italy.

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http://dx.doi.org/10.1016/j.cellsig.2011.09.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237777PMC
February 2012
12 Reads
32 Citations
4.320 Impact Factor

A Polymorphism within the Promoter of the Dopamine Receptor D1 (DRD1 -48A/G) Associates with Impaired Kidney Function in White Hypertensive Patients.

Transl Med UniSa 2012 Jan 18;2:10-9. Epub 2012 Jan 18.

Department of Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Federico II University, Naples, Italy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3728780PMC
January 2012
7 Reads
1 Citation

Adrenergic mechanism in the control of endothelial function.

Transl Med UniSa 2011 Sep 17;1:213-28. Epub 2011 Oct 17.

Department of Internal Medicine of Federico II University of Naples, Napoli, Italy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3728849PMC
September 2011
10 Reads
5 Citations

Towards a re-definition of 'cardiac hypertrophy' through a rational characterization of left ventricular phenotypes: a position paper of the Working Group 'Myocardial Function' of the ESC.

Eur J Heart Fail 2011 Aug 27;13(8):811-9. Epub 2011 Jun 27.

Myocardial Genetics, British Heart Foundation-Centre for Research Excellence, National Heart & Lung Institute, Imperial College London, Flowers Building, 4th floor, South Kensington Campus, London SW7 2AZ, UK.

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http://dx.doi.org/10.1093/eurjhf/hfr071DOI Listing
August 2011
36 Reads
11 Citations
6.530 Impact Factor

G protein-coupled receptor kinase 2 activity impairs cardiac glucose uptake and promotes insulin resistance after myocardial ischemia.

Circulation 2011 May 25;123(18):1953-62. Epub 2011 Apr 25.

George Zallie and Family Laboratory for Cardiovascular Gene Therapy, Center for Translational Medicine, Thomas Jefferson University, Philadelphia, PA, USA.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.110.988642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3113597PMC
May 2011
22 Reads
45 Citations
14.430 Impact Factor

G protein-coupled receptor kinase 2 in patients with acute myocardial infarction.

Am J Cardiol 2011 Apr 4;107(8):1125-30. Epub 2011 Feb 4.

Division of Internal Medicine, Department of Clinical Medicine and Cardiovascular and Immunologic Sciences, Federico II University, Naples, Italy.

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http://dx.doi.org/10.1016/j.amjcard.2010.12.006DOI Listing
April 2011
10 Reads
28 Citations
3.280 Impact Factor

Evaluation of the anti-angiogenic properties of the new selective αVβ3 integrin antagonist RGDechiHCit.

J Transl Med 2011 Jan 13;9. Epub 2011 Jan 13.

Department of Clinical Medicine, Cardiovascular & Immunologic Sciences, Federico II University of Naples, Italy.

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http://dx.doi.org/10.1186/1479-5876-9-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3027097PMC
January 2011
14 Reads
19 Citations
3.930 Impact Factor

Myocardial expression of FOXO3a-Atrogin-1 pathway in human heart failure.

Eur J Heart Fail 2010 Dec;12(12):1290-6

Department of Clinical Medicine, Cardiovascular and Immunology Sciences, Federico II University School of Medicine, Via S. Pansini, 5, 80131 Naples, Italy.

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http://dx.doi.org/10.1093/eurjhf/hfq102DOI Listing
December 2010
8 Reads
12 Citations
6.530 Impact Factor

Intracardiac injection of AdGRK5-NT reduces left ventricular hypertrophy by inhibiting NF-kappaB-dependent hypertrophic gene expression.

Hypertension 2010 Oct 26;56(4):696-704. Epub 2010 Jul 26.

Department of Clinical Medicine, Cardiovascular and Immunologic Sciences, Federico II University, Naples, Italy.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.110.155960DOI Listing
October 2010
22 Reads
48 Citations
6.480 Impact Factor

The GPIIIA PlA2 polymorphism is associated with an increased risk of cardiovascular adverse events.

BMC Cardiovasc Disord 2010 Sep 16;10:41. Epub 2010 Sep 16.

Department of Clinical Medicine, Cardiovascular and Immunologic Sciences, Federico II University School of Medicine, Naples, Italy.

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http://dx.doi.org/10.1186/1471-2261-10-41DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954874PMC
September 2010
31 Reads
24 Citations
1.500 Impact Factor

L41Q polymorphism of the G protein coupled receptor kinase 5 is associated with left ventricular apical ballooning syndrome.

Eur J Heart Fail 2010 Jan;12(1):13-6

Department of Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Federico II University, Via Pansini 5, Napoli 80131, Italy.

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http://dx.doi.org/10.1093/eurjhf/hfp173DOI Listing
January 2010
10 Reads
19 Citations
6.530 Impact Factor

The G protein coupled receptor kinase 2 plays an essential role in beta-adrenergic receptor-induced insulin resistance.

Cardiovasc Res 2009 Dec 20;84(3):407-15. Epub 2009 Jul 20.

Dipartimento di Medicina Clinica, Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Università Federico II, Via Pansini 5, 80131 Naples, Italy.

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http://dx.doi.org/10.1093/cvr/cvp252DOI Listing
December 2009
9 Reads
32 Citations
5.940 Impact Factor

A new synthetic protein, TAT-RH, inhibits tumor growth through the regulation of NFkappaB activity.

Mol Cancer 2009 Nov 9;8:97. Epub 2009 Nov 9.

Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Università Federico II, Napoli, Italia.

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http://dx.doi.org/10.1186/1476-4598-8-97DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2780391PMC
November 2009
6 Reads
12 Citations
4.260 Impact Factor

G-protein-coupled receptor kinases in cardiovascular conditions: focus on G-protein-coupled receptor kinase 2, a gain in translational medicine.

Biomark Med 2009 Oct;3(5):525-40

Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Federico II University, Via Sergio Pansini 5, Edificio 2, 80131 Napoli, Italy.

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http://dx.doi.org/10.2217/bmm.09.50DOI Listing
October 2009
8 Reads
2.860 Impact Factor

In vivo properties of the proangiogenic peptide QK.

J Transl Med 2009 Jun 8;7:41. Epub 2009 Jun 8.

Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Cattedra di Medicina Interna, Università degli Studi Federico II di Napoli, Italy.

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http://dx.doi.org/10.1186/1479-5876-7-41DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2702279PMC
June 2009
13 Reads
33 Citations
3.930 Impact Factor

Insufficient control of blood pressure and incident diabetes.

Diabetes Care 2009 May 17;32(5):845-50. Epub 2009 Feb 17.

Department of Clinical Medicine, Cardiovascular, and Immunological Sciences, Federico II University-Naples, Naples, Italy.

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http://dx.doi.org/10.2337/dc08-1881DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671117PMC
May 2009
9 Reads
10 Citations
8.420 Impact Factor

Enhanced GRK2 expression and desensitization of betaAR vasodilatation in hypertensive patients.

Clin Transl Sci 2008 Dec;1(3):215-20

Dipartimento di Medicina Clinica Scienze Cardiovascolari ed Immunologiche, Federico II University of Naples, Italy.

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http://dx.doi.org/10.1111/j.1752-8062.2008.00050.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350663PMC
December 2008
13 Reads
22 Citations
2.110 Impact Factor

The G-protein-coupled receptor kinase 5 inhibits NFkappaB transcriptional activity by inducing nuclear accumulation of IkappaB alpha.

Proc Natl Acad Sci U S A 2008 Nov 13;105(46):17818-23. Epub 2008 Nov 13.

Dipartimento di Medicina Clinica, Scienze Cardiovascolari, ed Immunologiche, Università Federico II, 80134 Naples, Italy.

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http://dx.doi.org/10.1073/pnas.0804446105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2584738PMC
November 2008
8 Reads
50 Citations
9.810 Impact Factor

Effects of Ile164 polymorphism of beta2-adrenergic receptor gene on coronary artery disease.

J Am Coll Cardiol 2008 Oct;52(17):1381-8

Department of Clinical Medicine, Cardiovascular and Immunology Sciences, Federico II University School of Medicine, Naples, Italy.

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http://dx.doi.org/10.1016/j.jacc.2008.07.034DOI Listing
October 2008
15 Reads
10 Citations
16.503 Impact Factor

Exercise promotes angiogenesis and improves beta-adrenergic receptor signalling in the post-ischaemic failing rat heart.

Cardiovasc Res 2008 May 18;78(2):385-94. Epub 2007 Dec 18.

Cattedra di Geriatria, Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Università Federico II, Via Pansini 5, 80131 Napoli, Italy.

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http://dx.doi.org/10.1093/cvr/cvm109DOI Listing
May 2008
21 Reads
29 Citations
5.940 Impact Factor

Exercise training and beta-blocker treatment ameliorate age-dependent impairment of beta-adrenergic receptor signaling and enhance cardiac responsiveness to adrenergic stimulation.

Am J Physiol Heart Circ Physiol 2007 Sep 8;293(3):H1596-603. Epub 2007 Jun 8.

Department of Internal Medicine, Cardiovascular Sciences and Immunology, University Federico II, Via Pansini 5, Edificio 2, 80131 Naples, Italy.

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http://dx.doi.org/10.1152/ajpheart.00308.2007DOI Listing
September 2007
76 Reads
17 Citations
3.840 Impact Factor

Endothelial beta2 adrenergic signaling to AKT: role of Gi and SRC.

Cell Signal 2007 Sep 29;19(9):1949-55. Epub 2007 May 29.

Department of Clinical Medicine, Cardiovascular and Immunological Sciences, Federico II University, Naples, Italy.

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http://dx.doi.org/10.1016/j.cellsig.2007.05.007DOI Listing
September 2007
5 Reads
21 Citations
4.320 Impact Factor

Prior exercise improves age-dependent vascular endothelial growth factor downregulation and angiogenesis responses to hind-limb ischemia in old rats.

J Gerontol A Biol Sci Med Sci 2007 May;62(5):471-80

Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Federico II University, Via Pansini 5, Edificio 2, 80131 Naples, Italy.

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May 2007
9 Reads
6 Citations
5.420 Impact Factor

The Pl(A1/A2) polymorphism of glycoprotein IIIa and cerebrovascular events in hypertension: increased risk of ischemic stroke in high-risk patients.

J Hypertens 2007 Mar;25(3):551-6

Department of Clinical Medicine, Cardiovascular & Immunological Sciences, Federico II University, Naples, Italy.

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http://dx.doi.org/10.1097/HJH.0b013e328013cd67DOI Listing
March 2007
16 Reads
33 Citations
4.720 Impact Factor

Lymphocyte G-protein-coupled receptor kinase-2 is upregulated in patients with Alzheimer's disease.

Neurosci Lett 2007 Mar 19;415(3):279-82. Epub 2007 Jan 19.

Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Università Federico II, Via Pansini 5, Edificio 2, 80131 Naples, Italy.

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http://dx.doi.org/10.1016/j.neulet.2007.01.034DOI Listing
March 2007
62 Reads
7 Citations
2.060 Impact Factor

Beta2-adrenergic receptor polymorphisms and treatment-induced regression of left ventricular hypertrophy in hypertension.

Clin Pharmacol Ther 2006 Dec;80(6):633-45

Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Università Federico II di Napoli, Italy.

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http://dx.doi.org/10.1016/j.clpt.2006.09.006DOI Listing
December 2006
7 Reads
12 Citations
7.903 Impact Factor

Targeting angiogenesis: structural characterization and biological properties of a de novo engineered VEGF mimicking peptide.

Proc Natl Acad Sci U S A 2005 Oct 26;102(40):14215-20. Epub 2005 Sep 26.

Istituto di Biostrutture e Bioimmagini, Consiglio Nazionale delle Ricerche, Via Mezzocannone 16, 80134 Napoli, Italy.

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http://dx.doi.org/10.1073/pnas.0505047102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1242306PMC
October 2005
5 Reads
38 Citations
9.810 Impact Factor

Elevated myocardial and lymphocyte GRK2 expression and activity in human heart failure.

Eur Heart J 2005 Sep 29;26(17):1752-8. Epub 2005 Jul 29.

Department of Medicina Clinica Scienze Cardiovascolari ed Immunologiche, Federico II University, Via Pansini 5, 80131 Naples, Italy.

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http://dx.doi.org/10.1093/eurheartj/ehi429DOI Listing
September 2005
21 Reads
54 Citations
15.203 Impact Factor

The use of a telematic connection for the follow-up of hypertensive patients improves the cardiovascular prognosis.

J Hypertens 2005 Jul;23(7):1417-23

Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche. Università degli studi Federico II, Napoli, Italy.

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July 2005
7 Reads
14 Citations
4.720 Impact Factor

Insulin-induced changes in beta-adrenergic response: an experimental study in the isolated rat papillary muscle.

Am J Hypertens 2005 Mar;18(3):348-53

Department of Health Sciences, University of Molise, Salvatore Maugeri Foundation, IRCCS, Scientific Institute of Telese/Campoli, Via dei Bagni Vecchi, 82037 Telese Terme, Italy.

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http://dx.doi.org/10.1016/j.amjhyper.2004.10.006DOI Listing
March 2005
4 Reads
7 Citations
2.852 Impact Factor

Role of beta2 adrenergic receptors in human atherosclerotic coronary arteries.

Circulation 2005 Jan 10;111(3):288-94. Epub 2005 Jan 10.

Division of Cardiology, Federico II University of Naples, Italy.

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http://dx.doi.org/10.1161/01.CIR.0000153270.25541.72DOI Listing
January 2005
4 Reads
12 Citations
14.430 Impact Factor

The Glu27 allele of the beta2 adrenergic receptor increases the risk of cardiac hypertrophy in hypertension.

J Hypertens 2004 Nov;22(11):2117-22

Department of Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Federico II University, Naples, Italy.

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November 2004
36 Reads
2 Citations
4.720 Impact Factor

AKT participates in endothelial dysfunction in hypertension.

Circulation 2004 Jun 10;109(21):2587-93. Epub 2004 May 10.

Department of Clinical Medicine, University of Naples Federico II, Italy.

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http://dx.doi.org/10.1161/01.CIR.0000129768.35536.FADOI Listing
June 2004
7 Reads
25 Citations
14.430 Impact Factor

In vivo adenoviral-mediated gene transfer of the beta ARKct to study the role of G beta gamma in arterial restenosis.

Methods Mol Biol 2004 ;237:181-92

Dipartmento di Medicina Clinica, Scienze Cardiovasculari ed Immunologiche, Federico II University, Naples, Italy.

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February 2004
3 Reads
2 Citations

Exercise restores beta-adrenergic vasorelaxation in aged rat carotid arteries.

Am J Physiol Heart Circ Physiol 2003 Jul 13;285(1):H369-74. Epub 2003 Mar 13.

Department of Clinic Medicine, University of Naples "Federico II," Via Sergio Pansini 5, 80131 Naples, Italy.

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http://dx.doi.org/10.1152/ajpheart.00019.2003DOI Listing
July 2003
3 Reads
7 Citations
3.840 Impact Factor

Growth hormone prolongs survival in experimental postinfarction heart failure.

J Am Coll Cardiol 2003 Jun;41(12):2154-63

Department of Internal Medicine and Cardiovascular Sciences, University Federico II, Naples, Italy.

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June 2003
4 Reads
8 Citations
16.500 Impact Factor

Transgenic mice targeting the heart unveil G protein-coupled receptor kinases as therapeutic targets.

Assay Drug Dev Technol 2003 Apr;1(2):347-55

Department of Clinical Medicine, Cardiovascular and Immunological Sciences, Federico II University, Napoli, Italy.

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http://dx.doi.org/10.1089/154065803321204484DOI Listing
April 2003
5 Reads
9 Citations
2.080 Impact Factor

Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice.

Proc Natl Acad Sci U S A 2002 Sep;99(19):12333-8

Kimmel Cancer Center, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1073/pnas.172376399DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC129445PMC
September 2002
22 Reads
126 Citations
9.810 Impact Factor

Beta(2)-adrenergic receptor gene delivery to the endothelium corrects impaired adrenergic vasorelaxation in hypertension.

Circulation 2002 Jul;106(3):349-55

Department of Clinical Medicine, Cardiovascular and Immunological Sciences, Federico II University, Naples, Italy.

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July 2002
4 Reads
21 Citations
14.430 Impact Factor

Cardiac betaARK1 upregulation induced by chronic salt deprivation in rats.

Hypertension 2001 Aug;38(2):255-60

Dipartimento di Medicina Clinica e Scienze Cardiovascolari, Federico II University of Naples, Naples, Italy.

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August 2001
2 Reads
7 Citations
6.480 Impact Factor

Regulation of myocardial betaARK1 expression in catecholamine-induced cardiac hypertrophy in transgenic mice overexpressing alpha1B-adrenergic receptors.

J Am Coll Cardiol 2001 Aug;38(2):534-40

Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA.

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August 2001
4 Reads
12 Citations
16.503 Impact Factor

Role of the sympathetic nervous system in cardiac remodeling in hypertension.

Clin Exp Hypertens 2001 Jan-Feb;23(1-2):35-43

Dipartimento di Medicina Clinica e Terapia Cardiovascolare, Università Federico II, Naples, Italy.

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June 2001
2 Reads
1 Citation
1.460 Impact Factor

Alterations in cardiac adrenergic signaling and calcium cycling differentially affect the progression of cardiomyopathy.

J Clin Invest 2001 Apr;107(8):967-74

Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309-0347, USA.

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http://dx.doi.org/10.1172/JCI12083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC199560PMC
April 2001
3 Reads
38 Citations
13.215 Impact Factor

Progression from hypertrophic to dilated cardiomyopathy in mice that express a mutant myosin transgene.

Am J Physiol Heart Circ Physiol 2001 Jan;280(1):H151-9

Department of Molecular Cellular and Developmental Biology, University of Colorado, Boulder 80309-0347, Colorado, USA.

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http://dx.doi.org/10.1152/ajpheart.2001.280.1.H151DOI Listing
January 2001
1 Read
17 Citations
3.840 Impact Factor

Myocardial G protein-coupled receptor kinases: implications for heart failure therapy.

Proc Assoc Am Physicians 1999 Sep-Oct;111(5):399-405

Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.

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November 1999
2 Reads
6 Citations

G beta gamma-mediated signaling: new therapeutic target for proliferative vascular disease.

IUBMB Life 1999 Sep;48(3):257-61

Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1080/713803509DOI Listing
September 1999
1 Read
3.143 Impact Factor

External support modulates G protein expression and receptor coupling in experimental vein grafts.

Surgery 1999 Aug;126(2):127-34

Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA.

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August 1999
4 Reads
3 Citations
3.380 Impact Factor

Targeting Gbeta gamma signaling in arterial vascular smooth muscle proliferation: a novel strategy to limit restenosis.

Proc Natl Acad Sci U S A 1999 Mar;96(7):3945-50

Department of Surgery, Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC22400PMC
March 1999
1 Read
18 Citations
9.810 Impact Factor

Correction of erythrocyte shape abnormalities in familial hypercholesterolemia after LDL-apheresis: does it influence cerebral hemodynamics?

Heart Vessels 1997 ;12(5):234-40

Department of Clinical and Experimental Medicine, Second Medical School, Federico II University, Naples, Italy.

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February 1999
2 Reads
1 Citation
2.110 Impact Factor

Ontogeny of cardiac beta-adrenoceptor desensitization mechanisms: agonist treatment enhances receptor/G-protein transduction rather than eliciting uncoupling.

J Mol Cell Cardiol 1999 Feb;31(2):413-23

Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1006/jmcc.1998.0875DOI Listing
February 1999
1 Read
11 Citations
4.660 Impact Factor

Bbeta-adrenergic receptor kinase-1 levels in catecholamine-induced myocardial hypertrophy: regulation by beta- but not alpha1-adrenergic stimulation.

Hypertension 1999 Jan;33(1 Pt 2):396-401

Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.

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January 1999
2 Reads
8 Citations
6.480 Impact Factor

Reciprocal in vivo regulation of myocardial G protein-coupled receptor kinase expression by beta-adrenergic receptor stimulation and blockade.

Circulation 1998 Oct;98(17):1783-9

Departments of Medicine, Surgery and Biochemistry, Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC, USA.

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October 1998
3 Reads
53 Citations
14.430 Impact Factor

Myocardial overexpression of GRK3 in transgenic mice: evidence for in vivo selectivity of GRKs.

Am J Physiol 1998 10;275(4):H1298-306

Department of Surgery, Duke University Medical Center, Durham North Carolina 27704, USA.

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http://dx.doi.org/10.1152/ajpheart.1998.275.4.H1298DOI Listing
October 1998
4 Reads
15 Citations

Adenoviral-mediated inhibition of G beta gamma signaling limits the hyperplastic response in experimental vein grafts.

Surgery 1998 Aug;124(2):177-86

Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA.

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August 1998
1 Read
3 Citations
3.380 Impact Factor

Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice.

Proc Natl Acad Sci U S A 1998 Jun;95(12):7000-5

Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC22717PMC
June 1998
2 Reads
103 Citations
9.810 Impact Factor

Targeting the receptor-Gq interface to inhibit in vivo pressure overload myocardial hypertrophy.

Science 1998 Apr;280(5363):574-7

Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA.

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April 1998
2 Reads
89 Citations
31.480 Impact Factor

Insulin enhances endothelial alpha2-adrenergic vasorelaxation by a pertussis toxin mechanism.

Hypertension 1997 Nov;30(5):1128-34

IRCCS Neuromed, Pozzilli (IS), Italy.

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November 1997
2 Reads
8 Citations
6.480 Impact Factor

Insulin modulation of an endothelial nitric oxide component present in the alpha2- and beta-adrenergic responses in human forearm.

J Clin Invest 1997 Oct;100(8):2007-14

IRCCS "INM NEUROMED," Pozzilli (IS), Italy.

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http://dx.doi.org/10.1172/JCI119732DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC508390PMC
October 1997
5 Reads
11 Citations
13.215 Impact Factor

The crosstalk between insulin and the sympathetic nervous system: possible implications in the pathogenesis of essential hypertension.

Blood Press Suppl 1996 ;1:38-42

Istituto Neurologico Mediterraneo "Neuromed", Pozzilli, Italy.

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May 1997
2 Reads
2 Citations

Association and cosegregation of stroke with impaired endothelium-dependent vasorelaxation in stroke prone, spontaneously hypertensive rats.

J Clin Invest 1996 Jul;98(2):256-61

Department of Experimental Medicine and Pathology, "La Sapienza" University, Rome, Italy.

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http://dx.doi.org/10.1172/JCI118787DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC507425PMC
July 1996
2 Reads
4 Citations
13.215 Impact Factor

Macula study with standardized echography.

Acta Ophthalmol Scand 1996 Apr;74(2):178-81

Department of Ophthalmology, University of Naples-Federico II, Italy.

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April 1996
4 Reads
1 Citation

Insulin modulation of beta-adrenergic vasodilator pathway in human forearm.

Circulation 1996 Apr;93(7):1403-10

Istituto Neurologico Mediterraneo, Neuromed, Pozzilli, Italy.

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April 1996
4 Reads
2 Citations
14.430 Impact Factor

Influence of digitalis on left ventricular functional response to exercise in congestive heart failure.

Am J Cardiol 1996 Mar;77(7):480-5

Department of Internal Medicine, Federico II University, Naples, Italy.

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March 1996
1 Read
1 Citation
3.280 Impact Factor

Effects of tissue factor induced by oxygen free radicals on coronary flow during reperfusion.

Nat Med 1996 Jan;2(1):35-40

Department of Internal Medicine, Second School of Medicine, University of Naples, Italy.

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January 1996
3 Reads
14 Citations
27.363 Impact Factor

Insulin modulation of vascular reactivity is already impaired in prehypertensive spontaneously hypertensive rats.

Hypertension 1995 Aug;26(2):290-3

IRCCS Sanatrix, Pozzilli, Italy.

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August 1995
2 Reads
4 Citations
6.480 Impact Factor

[Non-hemodynamic mechanisms of cardiovascular risk in the hypertensive patient: insulin resistance].

Cardiologia 1994 Dec;39(12 Suppl 1):295-8

I Clinica Medica, Università degli Studi, Federico II, Napoli.

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December 1994
2 Reads

Insulin blunts sympathetic vasoconstriction through the alpha 2-adrenergic pathway in humans.

Hypertension 1994 Oct;24(4):429-38

Department of Internal Medicine, School of Medicine, Federico II University, Naples, Italy.

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October 1994
1 Read
7 Citations
6.480 Impact Factor

Trandolapril in patients with essential hypertension: effects on vascular and cardiac structural changes.

J Cardiovasc Pharmacol 1994 ;23 Suppl 1:S20-4

Department of Internal Medicine, School of Medicine, Federico II University, Naples, Italy.

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September 1994
2 Reads
2.135 Impact Factor

Acute noradrenergic activation induces insulin resistance in human skeletal muscle.

Am J Physiol 1994 Feb;266(2 Pt 1):E242-7

Department of Internal Medicine, School of Medicine, Federico II University, Naples, Italy.

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http://dx.doi.org/10.1152/ajpendo.1994.266.2.E242DOI Listing
February 1994
1 Read
21 Citations

Insulin does not modulate reflex forearm sympathetic vasoconstriction in patients with essential hypertension.

J Hypertens Suppl 1993 Dec;11(5):S272-3

Department of Internal Medicine, Federico II University, Naples, Italy.

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December 1993
2 Reads

Digitalis restores the forearm sympathetic response to cardiopulmonary receptor unloading in hypertensive patients with left ventricular hypertrophy.

J Hypertens 1993 Dec;11(12):1395-402

Department of Internal Medicine, School of Medicine, Federico II University, Naples, Italy.

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December 1993
2 Reads
4.720 Impact Factor

Insulin reduces reflex forearm sympathetic vasoconstriction in healthy humans.

Hypertension 1993 Jun;21(6 Pt 2):1015-9

Institute of Internal Medicine, School of Medicine, Federico II University, Napoli, Italy.

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June 1993
2 Reads
3 Citations
6.480 Impact Factor

Abnormal sympathetic overactivity evoked by insulin in the skeletal muscle of patients with essential hypertension.

J Clin Invest 1992 Jul;90(1):24-9

Department of Internal Medicine, II School of Medicine, Federico II University, Napoli, Italy.

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http://dx.doi.org/10.1172/JCI115842DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC443058PMC
July 1992
2 Reads
25 Citations
13.215 Impact Factor

Top co-authors

Bruno Trimarco
Bruno Trimarco

Federico II University

54
Michele Ciccarelli
Michele Ciccarelli

University of Salerno

37
Daniela Sorriento
Daniela Sorriento

Department of Clinical Medicine

35
Gaetano Santulli
Gaetano Santulli

Federico II University of Naples

34
Maddalena Illario
Maddalena Illario

University of Naples Federico II

24
Ersilia Cipolletta
Ersilia Cipolletta

Department of Clinical Medicine

18
Pietro Campiglia
Pietro Campiglia

University of Salerno

13
Alfonso Campanile
Alfonso Campanile

Ospedale Maggiore Policlinico

9