Publications by authors named "Giorgio Racagni"

133 Publications

Chronic Treatment with a Phytosomal Preparation Containing L. and L. Affects Local Protein Synthesis by Modulating the BDNF-mTOR-S6 Pathway.

Biomedicines 2020 Nov 26;8(12). Epub 2020 Nov 26.

Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, 20133 Milan, Italy.

View Article and Find Full Text PDF
November 2020

Chronic Restraint Stress Inhibits the Response to a Second Hit in Adult Male Rats: A Role for BDNF Signaling.

Int J Mol Sci 2020 Aug 29;21(17). Epub 2020 Aug 29.

Department of Pharmacological and Biomolecular Sciences, Università deglI Studi di Milano, 20133 Milan, Italy.

View Article and Find Full Text PDF
August 2020

Renin-Angiotensin System and Coronavirus Disease 2019: A Narrative Review.

Front Cardiovasc Med 2020 11;7:143. Epub 2020 Aug 11.

Section of Pharmacology "L. Donatelli", Department of Experimental Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.

View Article and Find Full Text PDF
August 2020

Repeated cocaine exposure during adolescence impairs recognition memory in early adulthood: A role for BDNF signaling in the perirhinal cortex.

Dev Cogn Neurosci 2020 06 22;43:100789. Epub 2020 Apr 22.

Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Via Balzaretti 9, 20133 Milano, Italy. Electronic address:

View Article and Find Full Text PDF
June 2020

NSAIDs in patients with viral infections, including Covid-19: Victims or perpetrators?

Pharmacol Res 2020 07 29;157:104849. Epub 2020 Apr 29.

Department of Oncology and Onco-Hematology, University of Milan, Milan, Italy; Clinical Pharmacology Unit, ASST-GOM Niguarda Hospital, Milan, Italy.

View Article and Find Full Text PDF
July 2020

Current pharmacological treatments for COVID-19: What's next?

Br J Pharmacol 2020 11 15;177(21):4813-4824. Epub 2020 May 15.

Department of Experimental Medicine, Università degli studi della Campania "Luigi Vanvitelli", Naples, Italy.

View Article and Find Full Text PDF
November 2020

From Healthy Aging to Frailty: In Search of the Underlying Mechanisms.

Curr Med Chem 2019 ;26(20):3685-3701

Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy.

View Article and Find Full Text PDF
October 2019

Medication-Induced Akathisia with Newly Approved Antipsychotics in Patients with a Severe Mental Illness: A Systematic Review and Meta-Analysis.

CNS Drugs 2019 06;33(6):549-566

Department of Neurosciences, Research Group Psychiatry, KU Leuven, University Psychiatric Centre, 3070, Kortenberg, Belgium.

View Article and Find Full Text PDF
June 2019

The role of dopamine D receptors in the mechanism of action of cariprazine.

CNS Spectr 2020 06 23;25(3):343-351. Epub 2019 Apr 23.

Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan, Italy.

View Article and Find Full Text PDF
June 2020

On the Policy of the Italian Government in the Discovery, Development, and Access to Medicines.

Clin Ther 2018 11 27;40(11):1931-1940. Epub 2018 Oct 27.

Department of Experimental Medicine - Section of Pharmacology "L. Donatelli", University of Campania "Luigi Vanvitelli", Napoli, Italy.

View Article and Find Full Text PDF
November 2018

Pharmacokinetic drug interactions of the non-vitamin K antagonist oral anticoagulants (NOACs).

Pharmacol Res 2018 09 21;135:60-79. Epub 2018 Jul 21.

Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Via G. Balzaretti 9, 20133 Milan, Italy; IRCCS MultiMedica, via G. Fantoli 16, 20138 Milan, Italy. Electronic address:

View Article and Find Full Text PDF
September 2018

Upregulation of neurotrophins by S 47445, a novel positive allosteric modulator of AMPA receptors in aged rats.

Pharmacol Res 2017 Jul 23;121:59-69. Epub 2017 Apr 23.

Department of Pharmacological and Biomolecular Sciences, Universita' degli Studi di Milano, Milan, Italy. Electronic address:

View Article and Find Full Text PDF
July 2017

A new nomenclature for classifying psychotropic drugs.

Br J Clin Pharmacol 2017 08 24;83(8):1614-1616. Epub 2017 May 24.

Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.

View Article and Find Full Text PDF
August 2017

Genome-wide analysis of LPS-induced inflammatory response in the rat ventral hippocampus: Modulatory activity of the antidepressant agomelatine.

World J Biol Psychiatry 2018 08 24;19(5):390-401. Epub 2017 Mar 24.

b Department of Medical Biotechnology and Translational Medicine , University of Milan , Milan , Italy.

View Article and Find Full Text PDF
August 2018

A single cocaine exposure disrupts actin dynamics in the cortico-accumbal pathway of adolescent rats: modulation by a second cocaine injection.

Psychopharmacology (Berl) 2017 Apr 15;234(8):1217-1222. Epub 2017 Feb 15.

Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Via Balzaretti 9, 20133, Milan, Italy.

View Article and Find Full Text PDF
April 2017

Developmental Exposure to Cocaine Dynamically Dysregulates Cortical Arc/Arg3.1 Modulation in Response to a Challenge.

Neurotox Res 2017 02 10;31(2):289-297. Epub 2016 Nov 10.

Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Via Balzaretti 9, 20133, Milan, Italy.

View Article and Find Full Text PDF
February 2017

Region-specific effects of developmental exposure to cocaine on fibroblast growth factor-2 expression in the rat brain.

Psychopharmacology (Berl) 2016 Jul 30;233(14):2699-704. Epub 2016 Apr 30.

Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Via Balzaretti 9, 20133, Milano, Italy.

View Article and Find Full Text PDF
July 2016

Chronic Mild Stress Modulates Activity-Dependent Transcription of BDNF in Rat Hippocampal Slices.

Neural Plast 2016 31;2016:2592319. Epub 2015 Dec 31.

Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Via Balzaretti 9, 20133 Milano, Italy.

View Article and Find Full Text PDF
December 2016

Stress-induced anhedonia is associated with the activation of the inflammatory system in the rat brain: Restorative effect of pharmacological intervention.

Pharmacol Res 2016 Jan 1;103:1-12. Epub 2015 Nov 1.

Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milan, Italy. Electronic address:

View Article and Find Full Text PDF
January 2016

Short-term withdrawal from developmental exposure to cocaine activates the glucocorticoid receptor and alters spine dynamics.

Eur Neuropsychopharmacol 2015 Oct 13;25(10):1832-41. Epub 2015 May 13.

Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Via Balzaretti 9, 20133 Milano, Italy. Electronic address:

View Article and Find Full Text PDF
October 2015

Functional impairment in patients with major depression in clinical remission: results from the VIVAL-D-Rem, a nationwide, naturalistic, cross-sectional survey.

Int Clin Psychopharmacol 2015 May;30(3):129-41

aDepartment of Clinical and Experimental Sciences, Brescia University School of Medicine bUniversity Psychiatric Unit, Department of Mental Health, Brescia Spedali Civili, Brescia cDepartment of Systems Medicine, University Tor Vergata, Rome dDepartment of Pharmacological and Biomolecular Sciences, University of Milano, Milano, Italy eDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

View Article and Find Full Text PDF
May 2015

Brain-derived neurotrophic factor: a bridge between inflammation and neuroplasticity.

Front Cell Neurosci 2014 22;8:430. Epub 2014 Dec 22.

Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano Milan, Italy.

View Article and Find Full Text PDF
January 2015

The long-term impact of early adversities on psychiatric disorders: focus on neuronal plasticity.

Curr Pharm Des 2015 ;21(11):1388-95

Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Via Balzaretti 9, 20133 Milan, Italy.

View Article and Find Full Text PDF
May 2016

Synaptoproteomic analysis of a rat gene-environment model of depression reveals involvement of energy metabolism and cellular remodeling pathways.

Int J Neuropsychopharmacol 2014 Oct 31;18(3). Epub 2014 Oct 31.

Laboratory of Neuropsychopharmacology and Functional Neurogenomics, Dipartimento di Scienze Farmacologiche e Biomolecolari and Center of Excellence on Neurodegenerative Diseases, University of Milano, Milano, Italy (Drs Mallei, Failler, Corna, Racagni, and Popoli); Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden (Dr Mathé).

View Article and Find Full Text PDF
October 2014

Time-dependent activation of MAPK/Erk1/2 and Akt/GSK3 cascades: modulation by agomelatine.

BMC Neurosci 2014 Oct 21;15:119. Epub 2014 Oct 21.

Laboratory of Neuropsychopharmacology and Functional Neurogenomics, Dipartimento di Scienze Farmacologiche e Biomolecolari and Center of Excellence on Neurodegenerative Diseases (CEND), Università degli Studi di Milano, Via Balzaretti 9, Milano, 20133, Italy.

View Article and Find Full Text PDF
October 2014

A single exposure to cocaine during development elicits regionally-selective changes in basal basic Fibroblast Growth Factor (FGF-2) gene expression and alters the trophic response to a second injection.

Psychopharmacology (Berl) 2015 Feb 16;232(4):713-9. Epub 2014 Aug 16.

Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Via Balzaretti 9, 20133, Milano, Italy.

View Article and Find Full Text PDF
February 2015