Gilda Tachedjian

Gilda Tachedjian

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Gilda Tachedjian

Publications by authors named "Gilda Tachedjian"

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Short Communication: Effect of Seminal Plasma on Functions of Monocytes and Granulocytes.

AIDS Res Hum Retroviruses 2019 Jun;35(6):553-556

1 Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Australia.

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http://dx.doi.org/10.1089/AID.2018.0219DOI Listing
June 2019

A 30 kDa polyethylene glycol-enfuvirtide complex enhances the exposure of enfuvirtide in lymphatic viral reservoirs in rats.

Eur J Pharm Biopharm 2019 Apr 6;137:218-226. Epub 2019 Mar 6.

Department of Biochemistry and Molecular Biology, Bio21 Institute, University of Melbourne, 30 Flemington Road, Parkville 3052, Australia.

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http://dx.doi.org/10.1016/j.ejpb.2019.03.008DOI Listing
April 2019

Molecular dissection of an inhibitor targeting the HIV integrase dependent preintegration complex nuclear import.

Cell Microbiol 2019 01 27;21(1):e12953. Epub 2018 Sep 27.

Infection and Immunity Program, Monash Biomedicine Discovery Institute, and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia.

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http://dx.doi.org/10.1111/cmi.12953DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6585680PMC
January 2019

Host and Viral Proteins Modulating Ebola and Marburg Virus Egress.

Viruses 2019 01 3;11(1). Epub 2019 Jan 3.

Health Security Program, Life Sciences Discipline, Burnet Institute, Melbourne, VIC 3004, Australia.

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http://www.mdpi.com/1999-4915/11/1/25
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http://dx.doi.org/10.3390/v11010025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357148PMC
January 2019

The role of lactic acid production by probiotic Lactobacillus species in vaginal health.

Res Microbiol 2017 Nov - Dec;168(9-10):782-792. Epub 2017 Apr 20.

Department of Biophysics, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.resmic.2017.04.001DOI Listing
July 2018

Anti-HIV-1 Activity of Lactic Acid in Human Cervicovaginal Fluid.

mSphere 2018 07 5;3(4). Epub 2018 Jul 5.

Disease Elimination Program, Life Sciences Discipline, Burnet Institute, Melbourne, Victoria, Australia

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http://dx.doi.org/10.1128/mSphere.00055-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034077PMC
July 2018

The implausible "in vivo" role of hydrogen peroxide as an antimicrobial factor produced by vaginal microbiota.

Microbiome 2018 02 6;6(1):29. Epub 2018 Feb 6.

Institute for Genome Sciences, University of Maryland School of Medicine, 801 West Baltimore Street, Baltimore, MD, 21201, USA.

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http://dx.doi.org/10.1186/s40168-018-0418-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801833PMC
February 2018

Nonnucleoside Reverse Transcriptase Inhibitors Reduce HIV-1 Production from Latently Infected Resting CD4 T Cells following Latency Reversal.

Antimicrob Agents Chemother 2017 03 23;61(3). Epub 2017 Feb 23.

Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

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http://aac.asm.org/lookup/doi/10.1128/AAC.01736-16
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http://dx.doi.org/10.1128/AAC.01736-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5328526PMC
March 2017

Fragment Based Strategies for Discovery of Novel HIV-1 Reverse Transcriptase and Integrase Inhibitors.

Curr Top Med Chem 2016 ;16(10):1135-53

Centre for Biomedical Research, Burnet Institute, 85 Commercial Rd, Melbourne, VIC, 3004, Australia.

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http://dx.doi.org/10.2174/1568026615666150901114329DOI Listing
November 2016

Current and Emerging Drug Targets for Human Immunodeficiency Virus.

Curr Top Med Chem 2016 ;16(10):1072-3

Centre for Biomedical Research Burnet Institute, 85 Commercial Rd., Melbourne, VIC, 3004 Australia.

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http://dx.doi.org/10.2174/1568026616999150918145541DOI Listing
November 2016

Why Do We Need New Drug Classes for HIV Treatment and Prevention?

Curr Top Med Chem 2016 ;16(12):1343-9

Retroviral Biology and Antivirals Laboratory, Centre for Biomedical Research, Burnet Institute, GPO Box: 2284, Melbourne, Australia.

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http://dx.doi.org/10.2174/1568026616999151013124606DOI Listing
November 2016

Increasing prevalence of K65K and K66K in HIV-1 subtype B reverse transcriptase.

AIDS 2016 11;30(18):2787-2793

aRetroviral Biology and Antivirals Laboratory, Centre for Biomedical Research, Burnet Institute, Melbourne bDepartment of Microbiology, Monash University, Clayton, Victoria, Australia cBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada dDepartment of Infectious Diseases, Monash University eDepartment of Microbiology and Immunology at the Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia fDepartment of Medicine, Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA gUniversity of British Columbia, British Columbia, Canada hSchool of Science, College of Science, Engineering and Health, RMIT University, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1097/QAD.0000000000001272DOI Listing
November 2016

High fidelity simian immunodeficiency virus reverse transcriptase mutants have impaired replication in vitro and in vivo.

Virology 2016 May 19;492:1-10. Epub 2016 Feb 19.

Department of Microbiology and Immunology, The University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Victoria 3010, Australia; Melbourne Sexual Health Centre and Department of Infectious Diseases, Alfred Health, Central Clinical School, Monash University, Melbourne, Australia; ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, University of Melbourne, Parkville, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.virol.2016.02.008DOI Listing
May 2016

Contraction of the type I IFN locus and unusual constitutive expression of IFN-α in bats.

Proc Natl Acad Sci U S A 2016 Mar 22;113(10):2696-701. Epub 2016 Feb 22.

Australian Animal Health Laboratory, Health and Biosecurity Business Unit, Commonwealth Scientific and Industrial Research Organisation, Geelong, Victoria 3220, Australia;

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http://dx.doi.org/10.1073/pnas.1518240113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4790985PMC
March 2016

Critical Review: Mechanisms of HIV Transmission in Depo-Provera Users: The Likely Role of Hypoestrogenism.

J Acquir Immune Defic Syndr 2016 Jan;71(1):1-7

*Department of Obstetrics and Gynaecology, The University of Melbourne, Parkville, Victoria, Australia and the Royal Women's Hospital, Victoria, Australia;†Centre for Biomedical Research, Burnet Institute, Melbourne, Victoria, Australia;‡Department of Microbiology, Monash University, Clayton, Victoria, Australia;§Department of Infectious Diseases, Monash University, Melbourne, Victoria, Australia; and‖Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1097/QAI.0000000000000805DOI Listing
January 2016

Bats and Rodents Shape Mammalian Retroviral Phylogeny.

Sci Rep 2015 Nov 9;5:16561. Epub 2015 Nov 9.

Program in Emerging Infectious Diseases, Duke-NUS Graduate Medical School, Singapore, Singapore.

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http://www.nature.com/articles/srep16561
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http://dx.doi.org/10.1038/srep16561DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637884PMC
November 2015

Identification of mechanistically distinct inhibitors of HIV-1 reverse transcriptase through fragment screening.

Proc Natl Acad Sci U S A 2015 Jun 18;112(22):6979-84. Epub 2015 May 18.

Retroviral Biology and Antivirals Laboratory, Centre for Biomedical Research, Burnet Institute, Melbourne, VIC 3004, Australia; Department of Microbiology, Monash University, Clayton, VIC 3168, Australia; Department of Infectious Diseases, Monash University, Melbourne, 3004, Australia; Department of Microbiology and Immunology, University of Melbourne, Parkville, VIC 3010, Australia

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http://dx.doi.org/10.1073/pnas.1423900112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4460473PMC
June 2015

Antimicrobial and immune modulatory effects of lactic acid and short chain fatty acids produced by vaginal microbiota associated with eubiosis and bacterial vaginosis.

Front Physiol 2015 2;6:164. Epub 2015 Jun 2.

Centre for Biomedical Research, Burnet Institute Melbourne, VIC, Australia ; Department of Microbiology, Nursing and Health, Faculty of Medicine, Monash University Clayton, VIC, Australia ; Department of Infectious Disease, Monash University Melbourne, VIC, Australia ; Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity Parkville, VIC, Australia.

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http://dx.doi.org/10.3389/fphys.2015.00164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451362PMC
June 2015

Silent mutations at codons 65 and 66 in reverse transcriptase alleviate indel formation and restore fitness in subtype B HIV-1 containing D67N and K70R drug resistance mutations.

Nucleic Acids Res 2015 Mar 12;43(6):3256-71. Epub 2015 Mar 12.

Centre for Biomedical Research, Burnet Institute, Melbourne, Victoria 3004, Australia Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia Department of Infectious Diseases, Monash University, Melbourne, Victoria 3004, Australia Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3010, Australia

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http://nar.oxfordjournals.org/content/early/2015/03/12/nar.g
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http://nar.oxfordjournals.org/lookup/doi/10.1093/nar/gkv128
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http://dx.doi.org/10.1093/nar/gkv128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381058PMC
March 2015

Vaginal concentrations of lactic acid potently inactivate HIV.

J Antimicrob Chemother 2013 Sep 8;68(9):2015-25. Epub 2013 May 8.

Centre for Virology, Burnet Institute, Melbourne, Victoria 3004, Australia.

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http://dx.doi.org/10.1093/jac/dkt156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3743514PMC
September 2013

HIV-1 infection of T cells and macrophages are differentially modulated by virion-associated Hck: a Nef-dependent phenomenon.

Viruses 2013 Sep 18;5(9):2235-52. Epub 2013 Sep 18.

Centre for Biomedical Research, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne 3004, Victoria, Australia.

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http://dx.doi.org/10.3390/v5092235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798898PMC
September 2013

The seventh (and last?) International Microbicides Conference: from discovery to delivery.

Sex Health 2013 Jul;10(3):240-5

The University of New South Wales, Sydney, NSW, Australia.

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http://dx.doi.org/10.1071/SH12211DOI Listing
July 2013

Identification of diverse full-length endogenous betaretroviruses in megabats and microbats.

Retrovirology 2013 Mar 27;10:35. Epub 2013 Mar 27.

Retroviral Biology and Antivirals Laboratory, Centre for Virology, Burnet Institute, Melbourne, VIC 3004, Australia.

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http://dx.doi.org/10.1186/1742-4690-10-35DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3621094PMC
March 2013

No association between XMRV or related gammaretroviruses in Australian prostate cancer patients.

Virol J 2013 Jan 10;10:20. Epub 2013 Jan 10.

Retroviral Biology and Antivirals Laboratory, Centre for Virology, Burnet Institute, 85 Commercial Road, Melbourne, Victoria 3004, Australia.

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http://dx.doi.org/10.1186/1743-422X-10-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560155PMC
January 2013

Host-pathogen interactions of retroviruses.

Mol Biol Int 2012 24;2012:648512. Epub 2012 Oct 24.

Virus-Cell Interaction Section, HIV Drug Resistance Program, National Cancer Institute at Frederick, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1155/2012/648512DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488407PMC
November 2012

N348I in HIV-1 reverse transcriptase counteracts the synergy between zidovudine and nevirapine.

J Acquir Immune Defic Syndr 2012 Oct;61(2):153-7

Retroviral Biology and Antivirals Laboratory, Centre for Virology, Burnet Institute, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1097/QAI.0b013e3182657990DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458157PMC
October 2012

Identification of diverse groups of endogenous gammaretroviruses in mega- and microbats.

J Gen Virol 2012 Sep 13;93(Pt 9):2037-45. Epub 2012 Jun 13.

Center for Infectious Disease Dynamics, Department of Biology, The Pennsylvania State University, University Park, PA 16802, USA.

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http://dx.doi.org/10.1099/vir.0.043760-0DOI Listing
September 2012

Phosphatidylethanolamine binding is a conserved feature of cyclotide-membrane interactions.

J Biol Chem 2012 Sep 1;287(40):33629-43. Epub 2012 Aug 1.

Institute for Molecular Bioscience, The University of Queensland, Brisbane, 4072 Queensland, Australia.

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http://dx.doi.org/10.1074/jbc.M112.372011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460461PMC
September 2012

Discovery of retroviral homologs in bats: implications for the origin of mammalian gammaretroviruses.

J Virol 2012 Apr 8;86(8):4288-93. Epub 2012 Feb 8.

Institute of Molecular Ecology and Evolution, East China Normal University, Shanghai, China.

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http://dx.doi.org/10.1128/JVI.06624-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3318619PMC
April 2012

Targeting human immunodeficiency virus type 1 assembly, maturation and budding.

Drug Target Insights 2007 20;2:159-82. Epub 2007 Jul 20.

Molecular Interactions Group, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, 3004, Australia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155237PMC
October 2011

Maturation of the HIV reverse transcription complex: putting the jigsaw together.

Rev Med Virol 2009 Nov;19(6):324-37

Division of Infectious Diseases, Queensland Institute of Medical Research, Brisbane, Queensland 4006, Australia.

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http://dx.doi.org/10.1002/rmv.627DOI Listing
November 2009

Enhancement of human immunodeficiency virus type 1 replication is not intrinsic to all polyanion-based microbicides.

Antimicrob Agents Chemother 2009 Aug 15;53(8):3565-8. Epub 2009 Jun 15.

Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria 3004, Australia.

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http://dx.doi.org/10.1128/AAC.00102-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715623PMC
August 2009

Mechanisms of inhibition of HIV replication by non-nucleoside reverse transcriptase inhibitors.

Virus Res 2008 Jun 26;134(1-2):147-56. Epub 2008 Mar 26.

Division of Infectious Diseases, University of Pittsburgh School of Medicine, S817 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S016817020800007
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http://dx.doi.org/10.1016/j.virusres.2008.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2745993PMC
June 2008

Impact of residues in the nonnucleoside reverse transcriptase inhibitor binding pocket on HIV-1 reverse transcriptase heterodimer stability.

Curr HIV Res 2008 Mar;6(2):130-7

Molecular Interactions Group, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.2174/157016208783885065DOI Listing
March 2008

4th International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention.

Med J Aust 2007 Dec 3-17;187(11-12):610-2

National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, NSW, Australia.

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February 2008

Alteration of the proline at position 7 of the HIV-1 spacer peptide p1 suppresses viral infectivity in a strain dependent manner.

Curr HIV Res 2007 Jan;5(1):69-78

Virology Program, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.2174/157016207779316323DOI Listing
January 2007

Potent nonnucleoside reverse transcriptase inhibitors target HIV-1 Gag-Pol.

PLoS Pathog 2006 Nov;2(11):e119

Molecular Interactions Group, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Australia.

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http://dx.doi.org/10.1371/journal.ppat.0020119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1635531PMC
November 2006

Virological significance, prevalence and genetic basis of hypersusceptibility to nonnucleoside reverse transcriptase inhibitors.

Sex Health 2004 ;1(2):81-9

Molecular Interactions Group, Macfarlane Burnet Institute for Medical Research and Public Health, GPO Box 2284, Melbourne, Vic. 3001, Australia.

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http://dx.doi.org/10.1071/sh03012DOI Listing
January 2006

Antiretroviral compounds: mechanisms underlying failure of HAART to eradicate HIV-1.

Curr Med Chem 2005 ;12(15):1705-19

Center for Molecular Reproduction and Endocrinology, Monash Institute of Reproduction and Development, Monash University, Melbourne, Australia.

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http://dx.doi.org/10.2174/0929867054367211DOI Listing
October 2005

Mutations that abrogate human immunodeficiency virus type 1 reverse transcriptase dimerization affect maturation of the reverse transcriptase heterodimer.

J Virol 2005 Aug;79(16):10247-57

Molecular Interactions Group, Macfarlane Burnet Institute for Medical Research and Public Health, 85 Commercial Road, GPO Box 2284, Melbourne, Victoria 3001, Australia.

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http://dx.doi.org/10.1128/JVI.79.16.10247-10257.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1182633PMC
August 2005

Analysis of the contribution of reverse transcriptase and integrase proteins to retroviral RNA dimer conformation.

J Virol 2005 May;79(10):6338-48

The Macfarlane Burnet Institute for Medical Research and Public Health, Cnr Punt & Commercial Rds, Melbourne, Victoria, Australia 3004.

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http://dx.doi.org/10.1128/JVI.79.10.6338-6348.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1091692PMC
May 2005

Evaluation of a low cost reverse transcriptase assay for plasma HIV-1 viral load monitoring.

Curr HIV Res 2005 Apr;3(2):183-90

Clinical Research Laboratory, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.2174/1570162053506955DOI Listing
April 2005

The packaging and maturation of the HIV-1 Pol proteins.

Curr HIV Res 2005 Jan;3(1):73-85

Virology Program, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.2174/1570162052772942DOI Listing
January 2005

Efavirenz enhances the proteolytic processing of an HIV-1 pol polyprotein precursor and reverse transcriptase homodimer formation.

FEBS Lett 2005 Jan;579(2):379-84

Molecular Interactions Group, Macfarlane Burnet Institute for Medical Research and Public Health, 85 Commercial Road, Melbourne, Vic. 3004, Australia.

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http://doi.wiley.com/10.1016/j.febslet.2004.11.099
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http://dx.doi.org/10.1016/j.febslet.2004.11.099DOI Listing
January 2005

The effect of NNRTIs on HIV reverse transcriptase dimerization.

Curr Opin Investig Drugs 2003 Aug;4(8):966-73

Molecular Interactions Group, Macfarlane Burnet Institute for Medical Research and Public Health, Commercial Road, Melbourne, Victoria 3004, Australia.

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August 2003

Role of residues in the tryptophan repeat motif for HIV-1 reverse transcriptase dimerization.

J Mol Biol 2003 Feb;326(2):381-96

Department of Biochemistry and Molecular Biophysics, Columbia University College of Physicians and Surgeons, 701 West 168th St, New York, NY 10032, USA.

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http://dx.doi.org/10.1016/s0022-2836(02)01433-xDOI Listing
February 2003

Modulation of the oligomeric structures of HIV-1 retroviral enzymes by synthetic peptides and small molecules.

Eur J Biochem 2002 Nov;269(21):5103-11

Department of Medicine, Division of Infectious Diseases, University of Pittsburgh, PA 15261, USA.

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http://dx.doi.org/10.1046/j.1432-1033.2002.03216.xDOI Listing
November 2002