Georges Lacaud

Georges Lacaud

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Georges Lacaud

Georges Lacaud

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RUNX1 Dosage in Development and Cancer.

Authors:
Michael Lie-A-Ling Renaud Mevel Rahima Patel Karen Blyth Esther Baena Valerie Kouskoff Georges Lacaud

Mol Cells 2020 Feb;43(2):126-138

Cancer Research UK Stem Cell Biology Group, Cancer Research UK Manchester Institute, The University of Manchester, Macclesfield, SK10 4TG, UK.

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http://dx.doi.org/10.14348/molcells.2019.0301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057845PMC
February 2020

Transcriptional control of blood cell emergence.

Authors:
Sara Menegatti Marcel de Kruijf Eva Garcia-Alegria Georges Lacaud Valerie Kouskoff

FEBS Lett 2019 Dec 31;593(23):3304-3315. Epub 2019 Aug 31.

Developmental Haematopoiesis Group, Faculty of Biology, Medicine and Health, the University of Manchester, UK.

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http://dx.doi.org/10.1002/1873-3468.13585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6916194PMC
December 2019

Identification of gene specific cis-regulatory elements during differentiation of mouse embryonic stem cells: An integrative approach using high-throughput datasets.

Authors:
M S Vijayabaskar Debbie K Goode Nadine Obier Monika Lichtinger Amber M L Emmett Fatin N Zainul Abidin Nisar Shar Rebecca Hannah Salam A Assi Michael Lie-A-Ling Berthold Gottgens Georges Lacaud Valerie Kouskoff Constanze Bonifer David R Westhead

PLoS Comput Biol 2019 11 4;15(11):e1007337. Epub 2019 Nov 4.

School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom.

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http://dx.doi.org/10.1371/journal.pcbi.1007337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6855567PMC
November 2019

RUNX transcription factors: orchestrators of development.

Authors:
Renaud Mevel Julia E Draper Michael Lie-A-Ling Valerie Kouskoff Georges Lacaud

Development 2019 Sep 5;146(17). Epub 2019 Sep 5.

Cancer Research UK Stem Cell Biology Group, Cancer Research UK Manchester Institute, The University of Manchester, Alderley Park, Alderley Edge, Macclesfield SK10 4TG, UK

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http://dx.doi.org/10.1242/dev.148296DOI Listing
September 2019

The Oncogenic Transcription Factor RUNX1/ETO Corrupts Cell Cycle Regulation to Drive Leukemic Transformation.

Authors:
Natalia Martinez-Soria Lynsey McKenzie Julia Draper Anetta Ptasinska Hasan Issa Sandeep Potluri Helen J Blair Anna Pickin Asmida Isa Paulynn Suyin Chin Ricky Tirtakusuma Daniel Coleman Sirintra Nakjang Salam Assi Victoria Forster Mojgan Reza Ed Law Philip Berry Dorothee Mueller Cameron Osborne Alex Elder Simon N Bomken Deepali Pal James M Allan Gareth J Veal Peter N Cockerill Christian Wichmann Josef Vormoor Georges Lacaud Constanze Bonifer Olaf Heidenreich

Cancer Cell 2019 Apr;35(4):705

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http://dx.doi.org/10.1016/j.ccell.2019.03.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472942PMC
April 2019

Author Correction: Runx/Cbfβ complexes protect group 2 innate lymphoid cells from exhausted-like hyporesponsiveness during allergic airway inflammation.

Authors:
Chizuko Miyamoto Satoshi Kojo Motoi Yamashita Kazuyo Moro Georges Lacaud Katsuyuki Shiroguchi Ichiro Taniuchi Takashi Ebihara

Nat Commun 2019 03 1;10(1):1075. Epub 2019 Mar 1.

Laboratory for Transcriptional Regulation, RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, 230-0045, Japan.

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http://dx.doi.org/10.1038/s41467-019-08932-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397247PMC
March 2019

Runx/Cbfβ complexes protect group 2 innate lymphoid cells from exhausted-like hyporesponsiveness during allergic airway inflammation.

Authors:
Chizuko Miyamoto Satoshi Kojo Motoi Yamashita Kazuyo Moro Georges Lacaud Katsuyuki Shiroguchi Ichiro Taniuchi Takashi Ebihara

Nat Commun 2019 01 25;10(1):447. Epub 2019 Jan 25.

Laboratory for Transcriptional Regulation, RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, 230-0045, Japan.

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http://dx.doi.org/10.1038/s41467-019-08365-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347616PMC
January 2019

Early Human Hemogenic Endothelium Generates Primitive and Definitive Hematopoiesis In Vitro.

Authors:
Eva Garcia-Alegria Sara Menegatti Muhammad Z H Fadlullah Pablo Menendez Georges Lacaud Valerie Kouskoff

Stem Cell Reports 2018 11 25;11(5):1061-1074. Epub 2018 Oct 25.

Developmental Haematopoiesis Group, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester M13 9PT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2018.09.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234921PMC
November 2018

The Oncogenic Transcription Factor RUNX1/ETO Corrupts Cell Cycle Regulation to Drive Leukemic Transformation.

Authors:
Natalia Martinez-Soria Lynsey McKenzie Julia Draper Anetta Ptasinska Hasan Issa Sandeep Potluri Helen J Blair Anna Pickin Asmida Isa Paulynn Suyin Chin Ricky Tirtakusuma Daniel Coleman Sirintra Nakjang Salam Assi Victoria Forster Mojgan Reza Ed Law Philip Berry Dorothee Mueller Cameron Osborne Alex Elder Simon N Bomken Deepali Pal James M Allan Gareth J Veal Peter N Cockerill Christian Wichmann Josef Vormoor Georges Lacaud Constanze Bonifer Olaf Heidenreich

Cancer Cell 2018 10;34(4):626-642.e8

Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University, Brewery Lane, Newcastle upon Tyne NE1 7RU, UK; Princess Maxima Center for Pediatric Oncology, Utrecht 3584CS, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.08.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6179967PMC
October 2018

Single-cell transcriptomics reveal the dynamic of haematopoietic stem cell production in the aorta.

Authors:
Chloé S Baron Lennart Kester Anna Klaus Jean-Charles Boisset Roshana Thambyrajah Laurent Yvernogeau Valérie Kouskoff Georges Lacaud Alexander van Oudenaarden Catherine Robin

Nat Commun 2018 06 28;9(1):2517. Epub 2018 Jun 28.

Hubrecht Institute-KNAW, University Medical Center Utrecht, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands.

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http://dx.doi.org/10.1038/s41467-018-04893-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023921PMC
June 2018

HDAC1 and HDAC2 Modulate TGF-β Signaling during Endothelial-to-Hematopoietic Transition.

Authors:
Roshana Thambyrajah Muhammad Z H Fadlullah Martin Proffitt Rahima Patel Shaun M Cowley Valerie Kouskoff Georges Lacaud

Stem Cell Reports 2018 04;10(4):1369-1383

CRUK Stem Cell Biology Group, CRUK Manchester Institute, 555 Wilmslow Road, Manchester M20 4GJ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2018.03.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5998800PMC
April 2018

HOXB4 Promotes Hemogenic Endothelium Formation without Perturbing Endothelial Cell Development.

Authors:
Nadine Teichweyde Lara Kasperidus Sebastian Carotta Valerie Kouskoff Georges Lacaud Peter A Horn Stefan Heinrichs Hannes Klump

Stem Cell Reports 2018 03 15;10(3):875-889. Epub 2018 Feb 15.

Institute for Transfusion Medicine, University Hospital Essen, Virchowstraße 179, 45147 Essen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2018.01.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919293PMC
March 2018

Regulation of RUNX1 dosage is crucial for efficient blood formation from hemogenic endothelium.

Authors:
Michael Lie-A-Ling Elli Marinopoulou Andrew J Lilly Mairi Challinor Rahima Patel Christophe Lancrin Valerie Kouskoff Georges Lacaud

Development 2018 03 12;145(5). Epub 2018 Mar 12.

Stem Cell Biology Group, Cancer Research UK Manchester Institute, The University of Manchester, Wilmslow Road, Manchester M20 4BX, UK

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http://dx.doi.org/10.1242/dev.149419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5868988PMC
March 2018

A novel prospective isolation of murine fetal liver progenitors to study in utero hematopoietic defects.

Authors:
Julia E Draper Patrycja Sroczynska Muhammad Z H Fadlullah Rahima Patel Gillian Newton Wolfgang Breitwieser Valerie Kouskoff Georges Lacaud

PLoS Genet 2018 01 4;14(1):e1007127. Epub 2018 Jan 4.

Cancer Research UK Stem Cell Biology Group, Cancer Research UK Manchester Institute, Manchester Cancer Research Centre, The University of Manchester, Manchester, United Kingdom.

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http://dx.doi.org/10.1371/journal.pgen.1007127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5754050PMC
January 2018

SOX7 promotes the maintenance and proliferation of B cell precursor acute lymphoblastic cells.

Authors:
Sara Cuvertino Genny Filiciotto Ashish Masurekar Vaskar Saha Georges Lacaud Valerie Kouskoff

Oncotarget 2017 Sep 7;8(39):64974-64983. Epub 2016 Jul 7.

Cancer Research UK Manchester Institute, The University of Manchester, Manchester M20 4BX, UK.

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http://www.oncotarget.com/fulltext/10472
Publisher Site
http://dx.doi.org/10.18632/oncotarget.10472DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630305PMC
September 2017

Runx1 Structure and Function in Blood Cell Development.

Authors:
Constanze Bonifer Elena Levantini Valerie Kouskoff Georges Lacaud

Adv Exp Med Biol 2017 ;962:65-81

Cancer Research UK Manchester Institute, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1007/978-981-10-3233-2_5DOI Listing
September 2017

SOX7 expression is critically required in FLK1-expressing cells for vasculogenesis and angiogenesis during mouse embryonic development.

Authors:
Andrew J Lilly Andrzej Mazan Daryl A Scott Georges Lacaud Valerie Kouskoff

Mech Dev 2017 08 31;146:31-41. Epub 2017 May 31.

Cancer Research UK Manchester Institute, The University of Manchester, Wilmslow road, M20 4BX, UK; Division of Developmental Biology and Medicine, The University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.mod.2017.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496588PMC
August 2017

Mouse RUNX1C regulates premegakaryocytic/erythroid output and maintains survival of megakaryocyte progenitors.

Authors:
Julia E Draper Patrycja Sroczynska Hui Sun Leong Muhammad Z H Fadlullah Crispin Miller Valerie Kouskoff Georges Lacaud

Blood 2017 07 10;130(3):271-284. Epub 2017 May 10.

Cancer Research UK Stem Cell Biology Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, United Kingdom.

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http://dx.doi.org/10.1182/blood-2016-06-723635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833261PMC
July 2017

Primitive erythrocytes are generated from hemogenic endothelial cells.

Authors:
Monika Stefanska Kiran Batta Rahima Patel Magdalena Florkowska Valerie Kouskoff Georges Lacaud

Sci Rep 2017 07 25;7(1):6401. Epub 2017 Jul 25.

Cancer Research UK Stem Cell Biology Group, Cancer Research UK Manchester Institute, The University of Manchester, Wilmslow road, Manchester, M20 4BX, UK.

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http://dx.doi.org/10.1038/s41598-017-06627-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526883PMC
July 2017

Hemangioblast, hemogenic endothelium, and primitive versus definitive hematopoiesis.

Authors:
Georges Lacaud Valerie Kouskoff

Exp Hematol 2017 05 30;49:19-24. Epub 2016 Dec 30.

Division of Developmental Biology and Medicine, The University of Manchester, Manchester, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2016.12.009DOI Listing
May 2017

TIAM1 Antagonizes TAZ/YAP Both in the Destruction Complex in the Cytoplasm and in the Nucleus to Inhibit Invasion of Intestinal Epithelial Cells.

Authors:
Zoi Diamantopoulou Gavin White Muhammad Z H Fadlullah Marcel Dreger Karen Pickering Joe Maltas Garry Ashton Ruth MacLeod George S Baillie Valerie Kouskoff Georges Lacaud Graeme I Murray Owen J Sansom Adam F L Hurlstone Angeliki Malliri

Cancer Cell 2017 05 13;31(5):621-634.e6. Epub 2017 Apr 13.

Cell Signalling Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester M20 4BX, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.03.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425402PMC
May 2017

SOXF transcription factors in cardiovascular development.

Authors:
Andrew J Lilly Georges Lacaud Valerie Kouskoff

Semin Cell Dev Biol 2017 03 25;63:50-57. Epub 2016 Jul 25.

Cancer Research UK, Stem Cell Hematopoiesis, The University of Manchester, Wilmslow road, M20 4BX, UK. Electronic address:

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http://dx.doi.org/10.1016/j.semcdb.2016.07.021DOI Listing
March 2017

Cooperative binding of AP-1 and TEAD4 modulates the balance between vascular smooth muscle and hemogenic cell fate.

Authors:
Nadine Obier Pierre Cauchy Salam A Assi Jane Gilmour Michael Lie-A-Ling Monika Lichtinger Maarten Hoogenkamp Laura Noailles Peter N Cockerill Georges Lacaud Valerie Kouskoff Constanze Bonifer

Development 2016 12 17;143(23):4324-4340. Epub 2016 Oct 17.

Institute of Biomedical Research, College of Medicine and Dentistry, University of Birmingham, Birmingham B15 2TT, UK

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http://dx.doi.org/10.1242/dev.139857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5201045PMC
December 2016

Interplay between SOX7 and RUNX1 regulates hemogenic endothelial fate in the yolk sac.

Authors:
Andrew J Lilly Guilherme Costa Anne Largeot Muhammad Z H Fadlullah Michael Lie-A-Ling Georges Lacaud Valerie Kouskoff

Development 2016 12 17;143(23):4341-4351. Epub 2016 Oct 17.

Stem Cell Hematopoiesis, Cancer Research UK Manchester Institute, The University of Manchester, Manchester M20 4BX, UK

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http://dx.doi.org/10.1242/dev.140970DOI Listing
December 2016

Shedding light on hematopoietic stem cells: formation, regulation, and utilization.

Authors:
Catherine Robin Georges Lacaud Thierry Jaffredo

FEBS Lett 2016 11;590(22):3963-3964

Hubrecht Institute-KNAW & University Medical Center, Utrecht, The Netherlands.

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http://dx.doi.org/10.1002/1873-3468.12481DOI Listing
November 2016

Concise Review: Recent Advances in the In Vitro Derivation of Blood Cell Populations.

Authors:
Kiran Batta Sara Menegatti Eva Garcia-Alegria Magdalena Florkowska Georges Lacaud Valerie Kouskoff

Stem Cells Transl Med 2016 10 7;5(10):1330-1337. Epub 2016 Jul 7.

Cancer Research UK Stem Cell Haematopoiesis Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, United Kingdom

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http://dx.doi.org/10.5966/sctm.2016-0039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031184PMC
October 2016

New insights into the regulation by RUNX1 and GFI1(s) proteins of the endothelial to hematopoietic transition generating primordial hematopoietic cells.

Authors:
Roshana Thambyrajah Rahima Patel Milena Mazan Michael Lie-A-Ling Andrew Lilly Alexia Eliades Sara Menegatti Eva Garcia-Alegria Magdalena Florkowska Kiran Batta Valerie Kouskoff Georges Lacaud

Cell Cycle 2016 Aug 11;15(16):2108-2114. Epub 2016 Jul 11.

a CRUK Stem Cell Biology, Cancer Research UK Manchester Institute , Manchester , UK.

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http://dx.doi.org/10.1080/15384101.2016.1203491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993433PMC
August 2016

Corrigendum: Graphene Oxide promotes embryonic stem cell differentiation to haematopoietic lineage.

Authors:
Eva Garcia-Alegria Maria Iliut Monika Stefanska Claudio Silva Sebastian Heeg Susan J Kimber Valerie Kouskoff Georges Lacaud Aravind Vijayaraghavan Kiran Batta

Sci Rep 2016 07 4;6:28723. Epub 2016 Jul 4.

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http://dx.doi.org/10.1038/srep28723DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931678PMC
July 2016

SOX7-enforced expression promotes the expansion of adult blood progenitors and blocks B-cell development.

Authors:
Sara Cuvertino Georges Lacaud Valerie Kouskoff

Open Biol 2016 07;6(7)

Stem Cell Hematopoiesis Group, Cancer Research UK Manchester Institute, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK

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http://dx.doi.org/10.1098/rsob.160070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967825PMC
July 2016

The Hemogenic Competence of Endothelial Progenitors Is Restricted by Runx1 Silencing during Embryonic Development.

Authors:
Alexia Eliades Sarah Wareing Elli Marinopoulou Muhammad Z H Fadlullah Rahima Patel Joanna B Grabarek Berenika Plusa Georges Lacaud Valerie Kouskoff

Cell Rep 2016 06 26;15(10):2185-2199. Epub 2016 May 26.

Cancer Research UK Stem Cell Hematopoiesis Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester M20 4BX, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4906370PMC
June 2016

Graphene Oxide promotes embryonic stem cell differentiation to haematopoietic lineage.

Authors:
Eva Garcia-Alegria Maria Iliut Monika Stefanska Claudio Silva Sebastian Heeg Susan J Kimber Valerie Kouskoff Georges Lacaud Aravind Vijayaraghavan Kiran Batta

Sci Rep 2016 05 20;6:25917. Epub 2016 May 20.

Cancer Research UK Stem Cell Biology Group, Cancer Research UK Manchester Institute, University of Manchester, Manchester, United Kingdom.

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http://dx.doi.org/10.1038/srep25917DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873758PMC
May 2016

Correction: RUNX1B Expression Is Highly Heterogeneous and Distinguishes Megakaryocytic and Erythroid Lineage Fate in Adult Mouse Hematopoiesis.

Authors:
Julia E Draper Patrycja Sroczynska Olga Tsoulaki Hui Sun Leong Muhammad Z H Fadlullah Crispin Miller Valerie Kouskoff Georges Lacaud

PLoS Genet 2016 May 20;12(5):e1006084. Epub 2016 May 20.

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http://dx.doi.org/10.1371/journal.pgen.1006084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4874548PMC
May 2016

Expression of the MOZ-TIF2 oncoprotein in mice represses senescence.

Authors:
Anne Largeot Flor Maria Perez-Campo Elli Marinopoulou Michael Lie-a-Ling Valerie Kouskoff Georges Lacaud

Exp Hematol 2016 Apr 5;44(4):231-7.e4. Epub 2016 Feb 5.

Cancer Research UK Stem Cell Biology Group, CR-UK Manchester Institute, University of Manchester, Manchester, UK. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2015.12.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819447PMC
April 2016

Dynamic Gene Regulatory Networks Drive Hematopoietic Specification and Differentiation.

Authors:
Debbie K Goode Nadine Obier M S Vijayabaskar Michael Lie-A-Ling Andrew J Lilly Rebecca Hannah Monika Lichtinger Kiran Batta Magdalena Florkowska Rahima Patel Mairi Challinor Kirstie Wallace Jane Gilmour Salam A Assi Pierre Cauchy Maarten Hoogenkamp David R Westhead Georges Lacaud Valerie Kouskoff Berthold Göttgens Constanze Bonifer

Dev Cell 2016 Mar 25;36(5):572-87. Epub 2016 Feb 25.

Institute of Cancer end Genomic Sciences, College of Medicine and Dentistry, University of Birmingham, Birmingham B152TT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2016.01.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780867PMC
March 2016

GFI1 proteins orchestrate the emergence of haematopoietic stem cells through recruitment of LSD1.

Authors:
Roshana Thambyrajah Milena Mazan Rahima Patel Victoria Moignard Monika Stefanska Elli Marinopoulou Yaoyong Li Christophe Lancrin Thomas Clapes Tarik Möröy Catherine Robin Crispin Miller Shaun Cowley Berthold Göttgens Valerie Kouskoff Georges Lacaud

Nat Cell Biol 2016 Jan 30;18(1):21-32. Epub 2015 Nov 30.

CRUK Stem Cell Biology Group, Cancer Research UK Manchester Institute, The University of Manchester, Wilmslow Road, Manchester M20 4BX, UK.

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http://dx.doi.org/10.1038/ncb3276DOI Listing
January 2016

RUNX1B Expression Is Highly Heterogeneous and Distinguishes Megakaryocytic and Erythroid Lineage Fate in Adult Mouse Hematopoiesis.

Authors:
Julia E Draper Patrycja Sroczynska Olga Tsoulaki Hui Sun Leong Muhammad Z H Fadlullah Crispin Miller Valerie Kouskoff Georges Lacaud

PLoS Genet 2016 Jan 25;12(1):e1005814. Epub 2016 Jan 25.

Cancer Research UK Stem Cell Biology Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, United Kingdom.

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http://dx.doi.org/10.1371/journal.pgen.1005814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726605PMC
January 2016

FOXF1 inhibits hematopoietic lineage commitment during early mesoderm specification.

Authors:
Maud Fleury Alexia Eliades Peter Carlsson Georges Lacaud Valerie Kouskoff

Development 2015 Oct 20;142(19):3307-20. Epub 2015 Aug 20.

Cancer Research UK Stem Cell Hematopoiesis Group, Cancer Research UK Manchester Institute, The University of Manchester, Wilmslow Road, Manchester M20 4BX, UK

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http://dx.doi.org/10.1242/dev.124685DOI Listing
October 2015

Quantitative phosphoproteome analysis of embryonic stem cell differentiation toward blood.

Authors:
Manuela Piazzi Andrew Williamson Chia-Fang Lee Stella Pearson Georges Lacaud Valerie Kouskoff James A McCubrey Lucio Cocco Anthony D Whetton

Oncotarget 2015 May;6(13):10924-39

Stem Cell and Leukaemia Proteomics Laboratory, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4484429PMC
http://dx.doi.org/10.18632/oncotarget.3454DOI Listing
May 2015

Endoglin potentiates nitric oxide synthesis to enhance definitive hematopoiesis.

Authors:
Rabab Nasrallah Kathy Knezevic Thuan Thai Shane R Thomas Berthold Göttgens Georges Lacaud Valerie Kouskoff John E Pimanda

Biol Open 2015 May 15;4(7):819-29. Epub 2015 May 15.

Lowy Cancer Research Centre and the Prince of Wales Clinical School, UNSW Australia, Sydney, NSW 2052, Australia Department of Haematology, Prince of Wales Hospital, Sydney, NSW 2031, Australia

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http://dx.doi.org/10.1242/bio.011494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4571086PMC
May 2015

Developmental-stage-dependent transcriptional response to leukaemic oncogene expression.

Authors:
Kakkad Regha Salam A Assi Olga Tsoulaki Jane Gilmour Georges Lacaud Constanze Bonifer

Nat Commun 2015 May 28;6:7203. Epub 2015 May 28.

School of Cancer Sciences, Institute for Biomedical Research, University of Birmingham at Edgbaston, Birmingham B15 2TT, UK.

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http://dx.doi.org/10.1038/ncomms8203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458875PMC
May 2015

In vivo repopulating activity emerges at the onset of hematopoietic specification during embryonic stem cell differentiation.

Authors:
Stella Pearson Sara Cuvertino Maud Fleury Georges Lacaud Valerie Kouskoff

Stem Cell Reports 2015 Mar 5;4(3):431-44. Epub 2015 Feb 5.

Stem Cell Hematopoiesis Group, Cancer Research UK Manchester Institute, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22136711150002
Publisher Site
http://dx.doi.org/10.1016/j.stemcr.2015.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4375940PMC
March 2015

Direct reprogramming of murine fibroblasts to hematopoietic progenitor cells.

Authors:
Kiran Batta Magdalena Florkowska Valerie Kouskoff Georges Lacaud

Cell Rep 2014 Dec 26;9(5):1871-1884. Epub 2014 Nov 26.

CRUK Stem Cell Biology Group, Cancer Research UK Manchester Institute, The University of Manchester, Wilmslow Road, Manchester M20 4BX, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542300PMC
December 2014

RUNX1 positively regulates a cell adhesion and migration program in murine hemogenic endothelium prior to blood emergence.

Authors:
Michael Lie-A-Ling Elli Marinopoulou Yaoyong Li Rahima Patel Monika Stefanska Constanze Bonifer Crispin Miller Valerie Kouskoff Georges Lacaud

Blood 2014 Sep 31;124(11):e11-20. Epub 2014 Jul 31.

Cancer Research UK Stem Cell Biology Group, and.

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http://dx.doi.org/10.1182/blood-2014-04-572958DOI Listing
September 2014

MOZ-mediated repression of p16(INK) (4) (a) is critical for the self-renewal of neural and hematopoietic stem cells.

Authors:
Flor M Perez-Campo Guilherme Costa Michael Lie-A-Ling Stefano Stifani Valerie Kouskoff Georges Lacaud

Stem Cells 2014 Jun;32(6):1591-601

Cancer Research UK Stem Cell Biology Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, United Kingdom.

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http://dx.doi.org/10.1002/stem.1606DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237135PMC
June 2014

Smooth muscle cells largely develop independently of functional hemogenic endothelium.

Authors:
Monika Stefanska Guilherme Costa Michael Lie-A-Ling Valerie Kouskoff Georges Lacaud

Stem Cell Res 2014 Jan 5;12(1):222-32. Epub 2013 Nov 5.

Cancer Research UK Stem Cell Biology Group, Cancer Research UK Manchester Institute, University of Manchester, Manchester, UK. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2013.10.009DOI Listing
January 2014

The MYSTerious MOZ, a histone acetyltransferase with a key role in haematopoiesis.

Authors:
Flor M Perez-Campo Guilherme Costa Michael Lie-a-Ling Valerie Kouskoff Georges Lacaud

Immunology 2013 Jun;139(2):161-5

Cancer Research UK Stem Cell Biology Group, Paterson Institute for Cancer Research, The University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1111/imm.12072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3647182PMC
June 2013

RUNX1 reshapes the epigenetic landscape at the onset of haematopoiesis.

Authors:
Monika Lichtinger Richard Ingram Rebecca Hannah Dorothee Müller Deborah Clarke Salam A Assi Michael Lie-A-Ling Laura Noailles M S Vijayabaskar Mengchu Wu Daniel G Tenen David R Westhead Valerie Kouskoff Georges Lacaud Berthold Göttgens Constanze Bonifer

EMBO J 2012 Nov 12;31(22):4318-33. Epub 2012 Oct 12.

Section of Experimental Haematology, Leeds Institute of Molecular Medicine, University of Leeds, Leeds, UK.

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http://dx.doi.org/10.1038/emboj.2012.275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501222PMC
November 2012

ETV2 expression marks blood and endothelium precursors, including hemogenic endothelium, at the onset of blood development.

Authors:
Sarah Wareing Alexia Eliades Georges Lacaud Valerie Kouskoff

Dev Dyn 2012 Sep 16;241(9):1454-64. Epub 2012 Jul 16.

Cancer Research UK Stem Cell Hematopoiesis Group, Paterson Institute for Cancer Research, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1002/dvdy.23825DOI Listing
September 2012

The Flk1-Cre-mediated deletion of ETV2 defines its narrow temporal requirement during embryonic hematopoietic development.

Authors:
Sarah Wareing Andrzej Mazan Stella Pearson Berthold Göttgens Georges Lacaud Valerie Kouskoff

Stem Cells 2012 Jul;30(7):1521-31

Cancer Research UK Stem Cell Hematopoiesis Group, Paterson Institute for Cancer Research, University of Manchester, Wilmslow Road, Manchester, United Kingdom.

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http://doi.wiley.com/10.1002/stem.1115
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July 2012

GFI1 and GFI1B control the loss of endothelial identity of hemogenic endothelium during hematopoietic commitment.

Authors:
Christophe Lancrin Milena Mazan Monika Stefanska Rahima Patel Monika Lichtinger Guilherme Costa Ozge Vargel Nicola K Wilson Tarik Möröy Constanze Bonifer Berthold Göttgens Valerie Kouskoff Georges Lacaud

Blood 2012 Jul 5;120(2):314-22. Epub 2012 Jun 5.

Cancer Research UK Stem Cell Biology Group, Paterson Institute for Cancer Research, University of Manchester, Manchester, United Kingdom.

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http://dx.doi.org/10.1182/blood-2011-10-386094DOI Listing
July 2012

Origin of blood cells and HSC production in the embryo.

Authors:
Guilherme Costa Valerie Kouskoff Georges Lacaud

Trends Immunol 2012 May 23;33(5):215-23. Epub 2012 Feb 23.

Cancer Research UK Stem Cell Hematopoiesis Group, Paterson Institute for Cancer Research, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK.

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http://dx.doi.org/10.1016/j.it.2012.01.012DOI Listing
May 2012

SOX7 regulates the expression of VE-cadherin in the haemogenic endothelium at the onset of haematopoietic development.

Authors:
Guilherme Costa Andrzej Mazan Arnaud Gandillet Stella Pearson Georges Lacaud Valerie Kouskoff

Development 2012 May;139(9):1587-98

Cancer Research UK Stem Cell Research Group, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK.

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http://dx.doi.org/10.1242/dev.071282DOI Listing
May 2012

The transcription factor Mxd4 controls the proliferation of the first blood precursors at the onset of hematopoietic development in vitro.

Authors:
Katalin Boros Georges Lacaud Valerie Kouskoff

Exp Hematol 2011 Nov 23;39(11):1090-100. Epub 2011 Jul 23.

Cancer Research UK Stem Cell Hematopoiesis Group, Paterson Institute for Cancer Research, University of Manchester, UK.

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http://dx.doi.org/10.1016/j.exphem.2011.07.007DOI Listing
November 2011

Identification and characterization of a novel transcriptional target of RUNX1/AML1 at the onset of hematopoietic development.

Authors:
Cristina Ferreras Christophe Lancrin Michael Lie-A-Ling Valerie Kouskoff Georges Lacaud

Blood 2011 Jul 15;118(3):594-7. Epub 2011 Apr 15.

Cancer Research UK Stem Cell Biology Group, Paterson Institute for Cancer Research, University of Manchester, Manchester, United Kingdom.

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http://dx.doi.org/10.1182/blood-2010-06-294124DOI Listing
July 2011

Influencing hematopoietic differentiation of mouse embryonic stem cells using soluble heparin and heparan sulfate saccharides.

Authors:
Rebecca J Holley Claire E Pickford Graham Rushton Georges Lacaud John T Gallagher Valerie Kouskoff Catherine L R Merry

J Biol Chem 2011 Feb 10;286(8):6241-52. Epub 2010 Dec 10.

School of Materials, Materials Science Centre, The University of Manchester, Manchester M13 9PL, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M110.178483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057799PMC
February 2011

Embryonic stem cell-derived hemangioblasts remain epigenetically plastic and require PRC1 to prevent neural gene expression.

Authors:
Luca Mazzarella Helle F Jørgensen Jorge Soza-Ried Anna V Terry Stella Pearson Georges Lacaud Valerie Kouskoff Matthias Merkenschlager Amanda G Fisher

Blood 2011 Jan 28;117(1):83-7. Epub 2010 Sep 28.

Lymphocyte Development Group, Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College London, London, United Kingdom.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2010-03-27
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http://dx.doi.org/10.1182/blood-2010-03-273128DOI Listing
January 2011

The sequential expression of CD40 and Icam2 defines progressive steps in the formation of blood precursors from the mesoderm germ layer.

Authors:
Stella Pearson Christophe Lancrin Georges Lacaud Valerie Kouskoff

Stem Cells 2010 Jun;28(6):1089-98

Cancer Research UK Stem Cell Hematopoiesis Group, University of Manchester, Manchester, UK.

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http://doi.wiley.com/10.1002/stem.434
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June 2010

Contrasting effects of Sox17- and Sox18-sustained expression at the onset of blood specification.

Authors:
Alicia G Serrano Arnaud Gandillet Stella Pearson Georges Lacaud Valerie Kouskoff

Blood 2010 May 12;115(19):3895-8. Epub 2010 Mar 12.

Stem Cell Haematopoiesis Group, Cancer Research, UK.

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http://dx.doi.org/10.1182/blood-2009-10-247395DOI Listing
May 2010

Blood cell generation from the hemangioblast.

Authors:
Christophe Lancrin Patrycja Sroczynska Alicia G Serrano Arnaud Gandillet Cristina Ferreras Valerie Kouskoff Georges Lacaud

J Mol Med (Berl) 2010 Feb 25;88(2):167-72. Epub 2009 Oct 25.

Cancer Research UK, Stem Cell Biology Group, Paterson Institute for Cancer Research, University of Manchester, Wilmslow Road, Manchester, M20 4BX, UK.

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http://dx.doi.org/10.1007/s00109-009-0554-0DOI Listing
February 2010

The differential activities of Runx1 promoters define milestones during embryonic hematopoiesis.

Authors:
Patrycja Sroczynska Christophe Lancrin Valerie Kouskoff Georges Lacaud

Blood 2009 Dec 26;114(26):5279-89. Epub 2009 Oct 26.

Cancer Research UK Stem Cell Biology Group, Paterson Institute for Cancer Research, University of Manchester, Manchester, United Kingdom.

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http://dx.doi.org/10.1182/blood-2009-05-222307DOI Listing
December 2009

Sox7-sustained expression alters the balance between proliferation and differentiation of hematopoietic progenitors at the onset of blood specification.

Authors:
Arnaud Gandillet Alicia G Serrano Stella Pearson Michael Lie-A-Ling Georges Lacaud Valerie Kouskoff

Blood 2009 Nov 2;114(23):4813-22. Epub 2009 Oct 2.

Cancer Research UK, Stem Cell Haematopoiesis Group, Paterson Institute for Cancer Research, University of Manchester, Wilmslow Road, Manchester, United Kingdom.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2009-06-22
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http://dx.doi.org/10.1182/blood-2009-06-226290DOI Listing
November 2009

Early chromatin unfolding by RUNX1: a molecular explanation for differential requirements during specification versus maintenance of the hematopoietic gene expression program.

Authors:
Maarten Hoogenkamp Monika Lichtinger Hanna Krysinska Christophe Lancrin Deborah Clarke Andrew Williamson Luca Mazzarella Richard Ingram Helle Jorgensen Amanda Fisher Daniel G Tenen Valerie Kouskoff Georges Lacaud Constanze Bonifer

Blood 2009 Jul 1;114(2):299-309. Epub 2009 Apr 1.

Leeds Institute for Molecular Medicine, University of Leeds, Leeds, United Kingdom.

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http://dx.doi.org/10.1182/blood-2008-11-191890DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714206PMC
July 2009

Expression of the leukemia oncogene Lmo2 is controlled by an array of tissue-specific elements dispersed over 100 kb and bound by Tal1/Lmo2, Ets, and Gata factors.

Authors:
Josette-Renée Landry Nicolas Bonadies Sarah Kinston Kathy Knezevic Nicola K Wilson S Helen Oram Mary Janes Sandie Piltz Michelle Hammett Jacinta Carter Tina Hamilton Ian J Donaldson Georges Lacaud Jonathan Frampton George Follows Valerie Kouskoff Berthold Göttgens

Blood 2009 Jun 26;113(23):5783-92. Epub 2009 Jan 26.

Department of Haematology, Cambridge Institute for Medical Research, Cambridge University, Cambridge, United Kingdom.

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http://dx.doi.org/10.1182/blood-2008-11-187757DOI Listing
June 2009

The histone acetyl transferase activity of monocytic leukemia zinc finger is critical for the proliferation of hematopoietic precursors.

Authors:
Flor M Perez-Campo Julian Borrow Valerie Kouskoff Georges Lacaud

Blood 2009 May 5;113(20):4866-74. Epub 2009 Mar 5.

Paterson Institute for Cancer Research, University of Manchester, USA.

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http://dx.doi.org/10.1182/blood-2008-04-152017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2686138PMC
May 2009

In vitro differentiation of mouse embryonic stem cells as a model of early hematopoietic development.

Authors:
Patrycja Sroczynska Christophe Lancrin Stella Pearson Valerie Kouskoff Georges Lacaud

Methods Mol Biol 2009 ;538:317-34

Stem Cell Biology and Research, Paterson Institute for Cancer Research, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1007/978-1-59745-418-6_16DOI Listing
May 2009

The haemangioblast generates haematopoietic cells through a haemogenic endothelium stage.

Authors:
Christophe Lancrin Patrycja Sroczynska Catherine Stephenson Terry Allen Valerie Kouskoff Georges Lacaud

Nature 2009 Feb 28;457(7231):892-5. Epub 2009 Jan 28.

Cancer Research UK Stem Cell Biology Group.

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http://www.nature.com/articles/nature07679
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http://dx.doi.org/10.1038/nature07679DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661201PMC
February 2009

A developmentally regulated heparan sulfate epitope defines a subpopulation with increased blood potential during mesodermal differentiation.

Authors:
Rebecca J Baldwin Gerdy B ten Dam Toin H van Kuppevelt Georges Lacaud John T Gallagher Valerie Kouskoff Catherine L R Merry

Stem Cells 2008 Dec 11;26(12):3108-18. Epub 2008 Sep 11.

University of Manchester and Cancer Research UK Department of Medical Oncology, Manchester, United Kingdom.

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http://dx.doi.org/10.1634/stemcells.2008-0311DOI Listing
December 2008

Endoglin expression in blood and endothelium is differentially regulated by modular assembly of the Ets/Gata hemangioblast code.

Authors:
John E Pimanda Wan Y I Chan Nicola K Wilson Aileen M Smith Sarah Kinston Kathy Knezevic Mary E Janes Josette-Renée Landry Anja Kolb-Kokocinski Jonathan Frampton David Tannahill Katrin Ottersbach George A Follows Georges Lacaud Valerie Kouskoff Berthold Göttgens

Blood 2008 Dec 19;112(12):4512-22. Epub 2008 Sep 19.

Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2008-05-15
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http://dx.doi.org/10.1182/blood-2008-05-157560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682356PMC
December 2008

The stepwise specification of embryonic stem cells to hematopoietic fate is driven by sequential exposure to Bmp4, activin A, bFGF and VEGF.

Authors:
Stella Pearson Patrycja Sroczynska Georges Lacaud Valerie Kouskoff

Development 2008 Apr 13;135(8):1525-35. Epub 2008 Mar 13.

Cancer Research UK, Paterson Institute for Cancer Research, Manchester University, Wilmslow Road, M20 4BX, Manchester, UK.

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http://dx.doi.org/10.1242/dev.011767DOI Listing
April 2008

Quantitative proteomics analysis demonstrates post-transcriptional regulation of embryonic stem cell differentiation to hematopoiesis.

Authors:
Andrew J K Williamson Duncan L Smith David Blinco Richard D Unwin Stella Pearson Claire Wilson Crispin Miller Lee Lancashire Georges Lacaud Valerie Kouskoff Anthony D Whetton

Mol Cell Proteomics 2008 Mar 27;7(3):459-72. Epub 2007 Nov 27.

Stem Cell and Leukemia Proteomics Laboratory, Faculty of Medical and Human Sciences, University of Manchester, Kinnaird House, Kinnaird Road, Manchester M20 4QL, United Kingdom.

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http://dx.doi.org/10.1074/mcp.M700370-MCP200DOI Listing
March 2008

Gata2, Fli1, and Scl form a recursively wired gene-regulatory circuit during early hematopoietic development.

Authors:
John E Pimanda Katrin Ottersbach Kathy Knezevic Sarah Kinston Wan Y I Chan Nicola K Wilson Josette-Renée Landry Andrew D Wood Anja Kolb-Kokocinski Anthony R Green David Tannahill Georges Lacaud Valerie Kouskoff Berthold Göttgens

Proc Natl Acad Sci U S A 2007 Nov 25;104(45):17692-7. Epub 2007 Oct 25.

Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, United Kingdom.

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http://dx.doi.org/10.1073/pnas.0707045104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2077040PMC
November 2007

Feedback regulation of p38 activity via ATF2 is essential for survival of embryonic liver cells.

Authors:
Wolfgang Breitwieser Steve Lyons Ann Marie Flenniken Garry Ashton Gail Bruder Mark Willington Georges Lacaud Valerie Kouskoff Nic Jones

Genes Dev 2007 Aug;21(16):2069-82

Cell Regulation Department, Paterson Institute for Cancer Research, University of Manchester, Manchester M20 4BX, United Kingdom.

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http://dx.doi.org/10.1101/gad.430207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1948861PMC
August 2007

The paralogous hematopoietic regulators Lyl1 and Scl are coregulated by Ets and GATA factors, but Lyl1 cannot rescue the early Scl-/- phenotype.

Authors:
Wan Y I Chan George A Follows Georges Lacaud John E Pimanda Josette-Renee Landry Sarah Kinston Kathy Knezevic Sandie Piltz Ian J Donaldson Laure Gambardella Fred Sablitzky Anthony R Green Valerie Kouskoff Berthold Göttgens

Blood 2007 Mar 19;109(5):1908-16. Epub 2006 Oct 19.

Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, United Kingdom.

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http://dx.doi.org/10.1182/blood-2006-05-023226DOI Listing
March 2007

Sequential development of hematopoietic and cardiac mesoderm during embryonic stem cell differentiation.

Authors:
Valerie Kouskoff Georges Lacaud Staci Schwantz Hans Jöerg Fehling Gordon Keller

Proc Natl Acad Sci U S A 2005 Sep 2;102(37):13170-5. Epub 2005 Sep 2.

Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0501672102
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http://dx.doi.org/10.1073/pnas.0501672102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1201570PMC
September 2005

Tracking mesoderm formation and specification to the hemangioblast in vitro.

Authors:
Georges Lacaud Gordon Keller Valerie Kouskoff

Trends Cardiovasc Med 2004 Nov;14(8):314-7

Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Wilmslow Road, Manchester, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S105017380400144
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http://dx.doi.org/10.1016/j.tcm.2004.09.004DOI Listing
November 2004

Haploinsufficiency of Runx1 results in the acceleration of mesodermal development and hemangioblast specification upon in vitro differentiation of ES cells.

Authors:
Georges Lacaud Valerie Kouskoff Anne Trumble Staci Schwantz Gordon Keller

Blood 2004 Feb 2;103(3):886-9. Epub 2003 Oct 2.

Carl C. Icahn Center for Gene Therapy and Molecular Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2003-06-21
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http://dx.doi.org/10.1182/blood-2003-06-2149DOI Listing
February 2004

Tracking mesoderm induction and its specification to the hemangioblast during embryonic stem cell differentiation.

Authors:
Hans Jörg Fehling Georges Lacaud Atsushi Kubo Marion Kennedy Scott Robertson Gordon Keller Valerie Kouskoff

Development 2003 Sep;130(17):4217-27

Department of Immunology, Medical Faculty/University Clinics Ulm, Germany.

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http://dx.doi.org/10.1242/dev.00589DOI Listing
September 2003

Runx1 is essential for hematopoietic commitment at the hemangioblast stage of development in vitro.

Authors:
Georges Lacaud Lia Gore Marion Kennedy Valerie Kouskoff Paul Kingsley Christopher Hogan Leif Carlsson Nancy Speck James Palis Gordon Keller

Blood 2002 Jul;100(2):458-66

Carl C. Icahn Institute for Gene Therapy and Molecular Medicine, Mount Sinai School of Medicine, New York, NY, USA.

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http://dx.doi.org/10.1182/blood-2001-12-0321DOI Listing
July 2002