Publications

Brief Report: Late Efavirenz-Induced Ataxia and Encephalopathy: A Case Series.
J Acquir Immune Defic Syndr 2017 Aug;75(5):577-579
*North West Department of Health, Klerksdorp Tshepong Hospital Complex, Matlosana, South Africa; †Department of Internal Medicine, University of Witwatersrand, Johannesburg, South Africa; ‡Perinatal HIV Research Unit (PHRU), SA MRC Soweto Matlosana Collaborating Centre for HIV/AIDS and TB, University of the Witwatersrand, Johannesburg, South Africa; §Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa; ‖Department of Neurosciences, University of the Witwatersrand, Johannesburg, South Africa; and ¶Center for TB Research, Johns Hopkins University, Baltimore, MD.

Compatibility of next-generation first-line antiretrovirals with rifampicin-based antituberculosis therapy in resource limited settings.
Curr Opin HIV AIDS 2017 Jul;12(4):355-358
aDivision of Clinical Pharmacology, Department of Medicine, University of Cape Town, South Africa bSt Stephen's AIDS Trust and Imperial College, Chelsea and Westminster Hospital, London, UK cDivisions of Clinical Pharmacology and Infectious Diseases, Departments of Medicine, Pharmacology and Molecular Sciences, and International Health, Johns Hopkins University, Baltimore, Maryland, USA.

Changes in estimated glomerular filtration rate over time in South African HIV-1-infected patients receiving tenofovir: a retrospective cohort study.
J Int AIDS Soc 2017 Apr;20(1):1-8
Centre for Infectious Disease Epidemiology and Research, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa.

The Cape Town Clinical Decision Rule for Streptococcal Pharyngitis in Children.
Pediatr Infect Dis J 2017 Mar;36(3):250-255
From the *Department of Medicine, Groote Schuur Hospital and University of Cape Town; and †Division of Clinical Pharmacology, Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa; ‡Division of Medical Microbiology, Department of Pathology, Faculty of Medicine & Health Sciences, Stellenbosch University & NHLS Tygerberg, Tygerberg, South Africa; §College of Public Health & Health Informatics, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia; and ¶Division of Infectious Diseases, Department of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee.


Mortality in Severe HIV-TB Associates with Innate Immune Activation and Dysfunction of Monocytes.
Clin Infect Dis 2017 Mar 24. Epub 2017 Mar 24.
Clinical Infectious Diseases Research Initiative, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Anzio Road, 7925, Cape Town, South Africa.



Effect of Lopinavir and Nevirapine Concentrations on Viral Outcomes in Protease Inhibitor-experienced HIV-infected Children.
Pediatr Infect Dis J 2016 Dec;35(12):e378-e383
From the *Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa; †Centre for Infectious Diseases Epidemiology and Research, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa; ‡Gertrude H Sergievsky Center, College of Physicians and Surgeons, and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY; §Empilweni Services and Research Unit, Rahima Moosa Mother and Child Hospital, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa; ¶ICAP, Mailman School of Public Health, and College of Physicians & Surgeons, Columbia University, New York, NY; and ‖Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa.

Moderate to severe HIV-associated neurocognitive impairment: A randomized placebo-controlled trial of lithium.
Medicine (Baltimore) 2016 Nov;95(46):e5401
aDivision of Clinical Pharmacology, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University bDivision of Neuropsychiatry, Department of Psychiatry and Mental Health, Faculty of Health Sciences cDivision of Epidemiology and Biostatistics, School of Public Health and Family Medicine dDivision of Clinical Pharmacology, Department of Medicine, Faculty of Health Sciences, University of Cape Town, South Africa eDepartment of Psychiatry, University of Oxford, United Kingdom fInstitute of Virology and Immunobiology, University of Würzburg, Germany gDepartment of Medicine, Faculty of Health Sciences, University of Cape Town, South Africa.

Prolonged tuberculosis-associated immune reconstitution inflammatory syndrome: characteristics and risk factors.
BMC Infect Dis 2016 Sep 27;16(1):518. Epub 2016 Sep 27.
Division of Infectious Diseases and HIV Medicine, Department of Medicine, University of Cape Town, Observatory, 7925, South Africa.


Post-treatment effect of isoniazid preventive therapy on tuberculosis incidence in HIV-infected individuals on antiretroviral therapy.
AIDS 2016 May;30(8):1279-86
aDepartment of Infectious Disease Epidemiology, TB Modelling Group, TB Centre, Centre for the Mathematical Modelling of Infectious Diseases, London School of Hygiene and Tropical Medicine bDepartment of Infection and Population Health, Centre for Infectious Disease Epidemiology, University College London, London, UK cDepartment of Medicine, Institute of Infectious Disease and Molecular Medicine, University of Cape Town dDivision of Clinical Pharmacology, University of Cape Town, Cape Town, South Africa eTuberculosis Research Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland, USA fCentre for Infectious Disease Epidemiology and Research, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa gDepartment of Medicine, Imperial College London hThe Francis Crick Institute Mill Hill Laboratory, London, UK iInstitute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa.

Adverse Drug Reactions Causing Admission to Medical Wards: A Cross-Sectional Survey at 4 Hospitals in South Africa.
Medicine (Baltimore) 2016 May;95(19):e3437
From the Department of Medicine, Division of Clinical Pharmacology, University of Cape Town, Cape Town (JPM, CN, NK, AS, UM, MB, MFDS, RDW, GM, KC); Department of Medicine, East London Hospital Complex and Walter Sisulu University, East London (AGP); Department of Medicine, Edendale Hospital, Pietermaritzburg, South Africa (DPKW), US Centers for Disease Control and Prevention, Pretoria (EUI, GA); National Department of Health, Pretoria (MD); and Pharmaceutical Services, School of Health Sciences, University of KwaZulu-Natal, Durban, South Africa (MD).

Tuberculosis.
Lancet 2016 Mar 13;387(10024):1211-26. Epub 2015 Sep 13.
Division of Clinical Pharmacology, University of Cape Town, Cape Town, South Africa; Tuberculosis Research Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.

Risk Factors for Incident Diabetes in a Cohort Taking First-Line Nonnucleoside Reverse Transcriptase Inhibitor-Based Antiretroviral Therapy.
Medicine (Baltimore) 2016 Mar;95(9):e2844
From the Division of Clinical Pharmacology (SK, RL, GM, KC), Division of Endocrinology, Department of Medicine (JAD, NSL), Center for Infectious Disease Epidemiology and Research, School of Public Health and Family Medicine, University of Cape Town (MS), Aid for AIDS Management (Pty) Limited (MH), Health Intelligence Unit, Medscheme (Pty) Limited (LW), Chronic Disease Initiative for Africa, Cape Town (JAD, NSL), South Africa.


Plasma Efavirenz Concentrations Are Associated With Lipid and Glucose Concentrations.
Medicine (Baltimore) 2016 Jan;95(2):e2385
From the Division of Clinical Pharmacology, Department of Medicine, University of Cape Town (PZS, HMM, PJS, GM); Division of Endocrinology and Diabetic Medicine, Department of Medicine, University of Cape Town. Cape Town, South Africa (JAD, NSL); Vanderbilt University School of Medicine, Departments of Medicine, Pharmacology, Pathology, Microbiology & Immunology (DWH); Meharry Medical College, Department of Internal Medicine, Nashville, TN, United States of America (DWH).

A Randomized Controlled Trial of Real-Time Electronic Adherence Monitoring With Text Message Dosing Reminders in People Starting First-Line Antiretroviral Therapy.
J Acquir Immune Defic Syndr 2015 Dec;70(5):495-502
*Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine and Department of Medicine, University of Cape Town, Cape Town, South Africa; †Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa; ‡Department of Statistical Science, University of Cape Town, Cape Town, South Africa; §Harvard Medical School, Boston, MA; ‖Massachusetts General Hospital Center for Global Health, Boston, MA; and ¶Ragon Institute of Massachusetts General Hospital, Boston, MA.


Cytotoxic mediators in paradoxical HIV-tuberculosis immune reconstitution inflammatory syndrome.
J Immunol 2015 Feb 14;194(4):1748-54. Epub 2015 Jan 14.
Clinical Infectious Diseases Research Initiative, University of Cape Town, Cape Town, 7925 South Africa; Department of Medicine, University of Cape Town, Cape Town, 7925 South Africa; Medical Research Council National Institute for Medical Research, London NW7 1AA, United Kingdom; Division of Medicine, Imperial College London, London W2 1PG, United Kingdom;


Isoniazid plus antiretroviral therapy to prevent tuberculosis: a randomised double-blind, placebo-controlled trial.
Lancet 2014 Aug 13;384(9944):682-90. Epub 2014 May 13.
Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.

Matrix metalloproteinases and tissue damage in HIV-tuberculosis immune reconstitution inflammatory syndrome.
Eur J Immunol 2014 Jan 30;44(1):127-36. Epub 2013 Oct 30.
Clinical Infectious Diseases Research Initiative, Institute of Infectious Diseases and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

Mitochondrial genomics and antiretroviral therapy-associated metabolic complications in HIV-infected Black South Africans: a pilot study.
AIDS Res Hum Retroviruses 2013 Jul 15;29(7):1031-9. Epub 2013 Mar 15.
University of Cape Town Medical School, Department of Medicine, University of Cape Town, Cape Town, South Africa.

Role of the interleukin 10 family of cytokines in patients with immune reconstitution inflammatory syndrome associated with HIV infection and tuberculosis.
J Infect Dis 2013 Apr 9;207(7):1148-56. Epub 2013 Jan 9.
Clinical Infectious Diseases Research Initiative, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa.

A time-to-event pharmacodynamic model describing treatment response in patients with pulmonary tuberculosis using days to positivity in automated liquid mycobacterial culture.
Antimicrob Agents Chemother 2013 Feb 26;57(2):789-95. Epub 2012 Nov 26.
Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.

Effect of antiretroviral therapy on the diagnostic accuracy of symptom screening for intensified tuberculosis case finding in a South African HIV clinic.
Clin Infect Dis 2012 Dec 5;55(12):1698-706. Epub 2012 Sep 5.
Centre for Infectious Disease Research and Epidemiology, School of Public Health and Family Medicine, University of Cape Town, South Africa.

Impact of immune reconstitution inflammatory syndrome on antiretroviral therapy adherence.
Patient Prefer Adherence 2012 12;6:887-91. Epub 2012 Dec 12.
University of Cape Town, Department of Medicine, Division of Clinical Pharmacology, Cape Town, South Africa ; Johns Hopkins University, Bloomberg School of Public Health, Departments of International Health and Epidemiology, Baltimore, Maryland, USA ; Johns Hopkins University, Center for Tuberculosis Research, Baltimore, Maryland, USA.

Corticosteroid-modulated immune activation in the tuberculosis immune reconstitution inflammatory syndrome.
Am J Respir Crit Care Med 2012 Aug 14;186(4):369-77. Epub 2012 Jun 14.
Clinical Infectious Diseases Research Initiative, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa.


The SLCO1B1 rs4149032 polymorphism is highly prevalent in South Africans and is associated with reduced rifampin concentrations: dosing implications.
Antimicrob Agents Chemother 2011 Sep 27;55(9):4122-7. Epub 2011 Jun 27.
Department of Medicine, Division of Clinical Pharmacology, University of Cape Town, K-45 Old Main Building, Groote Schuur Hospital, Observatory, 7925 Cape Town, South Africa.

Low lopinavir plasma or hair concentrations explain second-line protease inhibitor failures in a resource-limited setting.
J Acquir Immune Defic Syndr 2011 Apr;56(4):333-9
Division of Medical Virology, Department of Pathology, NHLS Tygerberg and Stellenbosch University, Tygerberg, South Africa.



Lack of association between stavudine exposure and lipoatrophy, dysglycaemia, hyperlactataemia and hypertriglyceridaemia: a prospective cross sectional study.
AIDS Res Ther 2010 Jul 14;7:23. Epub 2010 Jul 14.
Department of Medicine, Division of Clinical Pharmacology, University of Cape Town, K45 Old Main Building, Groote Schuur Hospital, Observatory, 7925, Cape Town, South Africa.

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