Garry E Kiefer - Macrocyclics - CEO and Director of Rsearch

Garry E Kiefer

Macrocyclics

CEO and Director of Rsearch

Plano, Texas | United States

Main Specialties: Biotechnology, Chemistry, Nuclear Medicine

Garry E Kiefer - Macrocyclics - CEO and Director of Rsearch

Garry E Kiefer

Introduction

Primary Affiliation: Macrocyclics - Plano, Texas , United States

Specialties:

Publications

34Publications

330Reads

-Profile Views

Crystal structures of two polymorphic forms of DOTAM-mono-acid dihydrate.

Acta Crystallogr C Struct Chem 2018 May 6;74(Pt 5):542-547. Epub 2018 Apr 6.

Department of Chemistry, Louisiana State University, Baton Rouge, LA 70803, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1107/S2053229618004631DOI Listing
May 2018
1 Read

Unexpected Changes in the Population of Coordination Isomers for the Lanthanide Ion Complexes of DOTMA-Tetraglycinate.

Inorg Chem 2016 Sep 7;55(18):9297-305. Epub 2016 Sep 7.

Department of Chemistry, University of Texas at Dallas , Dallas, Texas 75080, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.inorgchem.6b01390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5221692PMC
September 2016
20 Reads
4.762 Impact Factor

Breaking the Barrier to Slow Water Exchange Rates for Optimal Magnetic Resonance Detection of paraCEST Agents.

Inorg Chem 2016 Mar 3;55(6):3007-14. Epub 2016 Mar 3.

Department of Chemistry, University of Texas at Dallas , 800 West Campbell Road, Richardson, Texas 75080, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.inorgchem.5b02850DOI Listing
March 2016
17 Reads
4.762 Impact Factor

CB-TE2A(+)·Cl(-)·3H2O: a short intermolecular hydrogen bond between zwitterionic bicyclo[6.6.2]tetraamine macrocycles.

Acta Crystallogr C Struct Chem 2016 Feb 19;72(Pt 2):139-42. Epub 2016 Jan 19.

Macrocyclics, Inc., 1309 Record Crossing, Dallas TX 75235, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1107/S2053229616000358DOI Listing
February 2016
1 Read

Amplifying the sensitivity of zinc(II) responsive MRI contrast agents by altering water exchange rates.

J Am Chem Soc 2015 Nov 29;137(44):14173-9. Epub 2015 Oct 29.

Department of Chemistry, University of Texas at Dallas , P.O. Box 830668, Richardson, Texas 75083, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jacs.5b09158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796656PMC
November 2015
9 Reads
12.113 Impact Factor

A pH-Responsive MRI Agent that Can Be Activated Beyond the Tissue Magnetization Transfer Window.

Angew Chem Int Ed Engl 2015 Jul 11;54(30):8662-4. Epub 2015 Jun 11.

Department of Chemistry, University of Texas at Dallas, 800 West Campbell Road, Richardson, TX 75080 (USA).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/anie.201502497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657548PMC
July 2015
1 Read
11.261 Impact Factor

A europium(III)-based PARACEST agent for sensing singlet oxygen by MRI.

Dalton Trans 2013 Jun 10;42(22):8066-9. Epub 2013 Apr 10.

Department of Chemistry, University of Texas at Dallas, 800 West Campbell Road, Richardson, TX 75080, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/c3dt50194aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3692361PMC
June 2013
5 Reads
4.197 Impact Factor

(68)Ga small peptide imaging: comparison of NOTA and PCTA.

Bioconjug Chem 2012 Nov 19;23(11):2239-46. Epub 2012 Oct 19.

Nordion, 4004 Wesbrook Mall, Vancouver, British Columbia, Canada, V6T 2A3.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/bc300348dDOI Listing
November 2012
4 Reads
4.513 Impact Factor

Pharmacokinetic modulation of radiolabeled chelates facilitated by phosphonate ester coordinating groups.

Mol Pharm 2012 Aug 22;9(8):2180-6. Epub 2012 Jun 22.

Nordion, 4004 Wesbrook Mall, Vancouver, British Columbia, Canada V6T 2A3.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/mp300024cDOI Listing
August 2012
14 Reads
4.384 Impact Factor

Nanoparticle-based PARACEST agents: the quenching effect of silica nanoparticles on the CEST signal from surface-conjugated chelates.

Contrast Media Mol Imaging 2012 Jan-Feb;7(1):19-25

Department of Chemistry, University of Texas at Dallas, Richardson, TX 75083, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cmmi.459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400155PMC
June 2012
1 Read
2.923 Impact Factor

Quantification of water exchange kinetics for targeted PARACEST perfluorocarbon nanoparticles.

NMR Biomed 2012 Feb 12;25(2):279-85. Epub 2011 Jul 12.

Cardiovascular Division, Washington University, St. Louis, MO, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/nbm.1746DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3624887PMC
February 2012
4 Reads
3.044 Impact Factor

Evaluation of 64Cu-labeled bifunctional chelate-bombesin conjugates.

Bioconjug Chem 2011 Aug 29;22(8):1729-35. Epub 2011 Jul 29.

Centre d'imagerie moléculaire de Sherbrooke, Department of Nuclear Medicine and Radiobiology, Université de Sherbrooke, 3001, 12th North Avenue Sherbrooke, Qubec, Canada, J1H 5N4.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/bc2002665DOI Listing
August 2011
7 Reads
4.513 Impact Factor

Strategies for labeling proteins with PARACEST agents.

Bioorg Med Chem 2011 Feb 18;19(3):1106-14. Epub 2010 Jun 18.

Department of Chemistry, University of Texas at Dallas, PO Box 830688, Richardson, TX 75083, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmc.2010.06.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3085090PMC
February 2011
2 Reads
2.793 Impact Factor

Comparison of bifunctional chelates for (64)Cu antibody imaging.

Eur J Nucl Med Mol Imaging 2010 Nov 16;37(11):2117-26. Epub 2010 Jun 16.

MDS Nordion, Vancouver, BC, V6T 2A3, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00259-010-1506-1DOI Listing
November 2010
23 Reads
5.383 Impact Factor

A responsive europium(III) chelate that provides a direct readout of pH by MRI.

J Am Chem Soc 2010 Oct;132(40):14002-3

Department of Chemistry, University of Texas at Dallas, P.O. Box 830668, Richardson, Texas 75083, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/ja106018nDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951490PMC
October 2010
2 Reads
12.113 Impact Factor

Multifunctional Polymeric Scaffolds for Enhancement of PARACEST Contrast Sensitivity and Performance: The Effects of Random Copolymer Variations.

Macromolecules 2010 Aug;43(16):6616-6624

Department of Chemistry, University of Texas at Dallas, P.O. Box 830668, Richardson, Texas 75083.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/ma100776dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2936783PMC
August 2010
1 Read
5.800 Impact Factor

Conjugation and radiolabeling of monoclonal antibodies with zirconium-89 for PET imaging using the bifunctional chelate p-isothiocyanatobenzyl-desferrioxamine.

Nat Protoc 2010 Apr 25;5(4):739-43. Epub 2010 Mar 25.

Department of Otolaryngology, VU University Medical Center, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nprot.2010.13DOI Listing
April 2010
4 Reads

Evaluation of bifunctional chelates for the development of gallium-based radiopharmaceuticals.

Bioconjug Chem 2010 Mar 22;21(3):531-6. Epub 2010 Feb 22.

MDS Nordion, 4004 Wesbrook Mall, Vancouver, British Columbia, Canada V6T 2A3, Ottawa Heart Institute, Ottawa, Ontario, Canada, MDS Nordion, Kanata, Ontario, Canada, and Macrocyclics, Dallas, Texas.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/bc900443aDOI Listing
March 2010
13 Reads
4.513 Impact Factor

p-Isothiocyanatobenzyl-desferrioxamine: a new bifunctional chelate for facile radiolabeling of monoclonal antibodies with zirconium-89 for immuno-PET imaging.

Eur J Nucl Med Mol Imaging 2010 Feb 18;37(2):250-9. Epub 2009 Sep 18.

Department of Otolaryngology/Head and Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00259-009-1263-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2816257PMC
February 2010
50 Reads
5.383 Impact Factor

Synthesis and evaluation of lanthanide ion DOTA-tetraamide complexes bearing peripheral hydroxyl groups.

J Biol Inorg Chem 2009 Mar 13;14(3):421-38. Epub 2008 Dec 13.

Department of Chemistry, University of Texas at Dallas, P.O. Box 803066, Richardson, TX 75083, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00775-008-0459-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2796837PMC
March 2009
10 Reads
2.538 Impact Factor

(S)-5-(p-nitrobenzyl)-PCTA, a promising bifunctional ligand with advantageous metal ion complexation kinetics.

Bioconjug Chem 2009 Mar;20(3):565-75

Department of Chemistry, University of Texas at Dallas, Richardson, TX 75080, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/bc8004914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765549PMC
March 2009
1 Read
4.513 Impact Factor

Evaluation of novel bifunctional chelates for the development of Cu-64-based radiopharmaceuticals.

Nucl Med Biol 2008 Nov;35(8):875-82

MDS Nordion, 4004 Wesbrook Mall, Vancouver, BC, Canada V6T 2A3.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nucmedbio.2008.09.001DOI Listing
November 2008
8 Reads
2.412 Impact Factor

Polymeric PARACEST agents for enhancing MRI contrast sensitivity.

J Am Chem Soc 2008 Oct 26;130(42):13854-5. Epub 2008 Sep 26.

Department of Chemistry, University of Texas at Dallas, P.O. Box 830668, Richardson, Texas 75083, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/ja805775uDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2723842PMC
October 2008
6 Reads
12.113 Impact Factor

Spectral properties of a bifunctional PARACEST europium chelate: an intermediate for targeted imaging applications.

Contrast Media Mol Imaging 2007 Jan-Feb;2(1):55-8

Macrocyclics, 2110 Research Row, STE 425, Dallas, TX 75235, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cmmi.125DOI Listing
April 2007
2 Reads
2.923 Impact Factor

A bridge to coordination isomer selection in lanthanide(III) DOTA-tetraamide complexes.

Inorg Chem 2007 Apr 13;46(7):2584-95. Epub 2007 Feb 13.

Department of Chemistry, University of Texas at Dallas, P.O. Box 830660, Richardson, Texas 75083-0688, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/ic062184+DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2556184PMC
April 2007
3 Reads
4.762 Impact Factor

Targeted PARACEST nanoparticle contrast agent for the detection of fibrin.

Magn Reson Med 2006 Dec;56(6):1384-8

Department of Medicine, Cardiovascular Division, Washington University, St. Louis, Missouri 63108, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/mrm.21093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920499PMC
December 2006
5 Reads
3.571 Impact Factor

Novel monoclonal antibodies with specificity for chelated uranium(VI): isolation and binding properties.

Bioconjug Chem 2004 Sep-Oct;15(5):1125-36

Division of Basic Pharmaceutical Sciences, College of Pharmacy, Xavier University of Louisiana, New Orleans, Louisiana, USA.

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/abs/10.1021/bc049889p
Publisher Site
http://dx.doi.org/10.1021/bc049889pDOI Listing
February 2005
3 Reads
4.513 Impact Factor

A new, facile synthesis of 1,4,7,10-tetraazacyclododecane: cyclen.

J Org Chem 2002 Jun;67(12):4081-5

The Dow Chemical Company, 2301 N. Brazosport Blvd., B-1222 Freeport, Texas 77541-3257, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jo016111dDOI Listing
June 2002
1 Read
4.721 Impact Factor