Gabriela Plesa

Gabriela Plesa

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Gabriela Plesa

Gabriela Plesa

Publications by authors named "Gabriela Plesa"

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Phase I Study of Lentiviral-Transduced Chimeric Antigen Receptor-Modified T Cells Recognizing Mesothelin in Advanced Solid Cancers.

Mol Ther 2019 Jul 30. Epub 2019 Jul 30.

Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA; Division of Hematology-Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15250016193032
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http://dx.doi.org/10.1016/j.ymthe.2019.07.015DOI Listing
July 2019

CRISPR/Cas9-based genome editing in the era of CAR T cell immunotherapy.

Hum Vaccin Immunother 2019 2;15(5):1126-1132. Epub 2019 Apr 2.

a Center for Cellular Immunotherapies, Abramson Cancer Center , University of Pennsylvania , Philadelphia , PA , USA.

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http://dx.doi.org/10.1080/21645515.2019.1571893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6605860PMC
April 2019

Activity of Mesothelin-Specific Chimeric Antigen Receptor T Cells Against Pancreatic Carcinoma Metastases in a Phase 1 Trial.

Gastroenterology 2018 07 20;155(1):29-32. Epub 2018 Mar 20.

Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1053/j.gastro.2018.03.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6035088PMC
July 2018

Retroviral and Lentiviral Safety Analysis of Gene-Modified T Cell Products and Infused HIV and Oncology Patients.

Mol Ther 2018 01 20;26(1):269-279. Epub 2017 Oct 20.

Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2017.10.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5763152PMC
January 2018

Overcoming barriers of car T-cell therapy in patients with mesothelin-expressing cancers.

Immunotherapy 2017 08 3;9(9):767-780. Epub 2017 Aug 3.

Department of Gynecologic Oncology of the University of Pennsylvania, The University of Pennsylvania Health System, 3400 Spruce street, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.2217/imt-2017-0026DOI Listing
August 2017

Possible Compartmental Cytokine Release Syndrome in a Patient With Recurrent Ovarian Cancer After Treatment With Mesothelin-targeted CAR-T Cells.

J Immunother 2017 04;40(3):104-107

*Department of Obstetrics and Gynecology ‡Department of Pathology and Laboratory Medicine, Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia †Department of Obstetrics and Gynecology, Lancaster General Health/Penn Medicine, Lancaster, PA §Department of Medicine and Cancer Center, Massachusetts General Hospital, Boston, MA.

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http://dx.doi.org/10.1097/CJI.0000000000000160DOI Listing
April 2017

Engineered T cells for cancer therapy.

Cancer Immunol Immunother 2014 Sep 19;63(9):969-75. Epub 2014 Jun 19.

Abramson Cancer Center, University of Pennsylvania, 3400 Civic Center Boulevard, 8th Floor, Philadelphia, PA, 19104-5156, USA,

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http://dx.doi.org/10.1007/s00262-014-1568-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142345PMC
September 2014

Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV.

N Engl J Med 2014 Mar;370(10):901-10

From the Perelman School of Medicine, University of Pennsylvania, Philadelphia (P.T., I.F., M.K., R.G.C., G.B.-S., G.P., W.-T.H., B.L.L., C.H.J.); Albert Einstein College of Medicine, Bronx, NY (D.S.); and Sangamo BioSciences, Richmond, CA (W.W.T., S.Q.W., G.L., S.K.S., R.T.S., M.A.G., G.N., M.C.H., P.D.G., D.G.A.).

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http://www.nejm.org/doi/10.1056/NEJMoa1300662
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http://dx.doi.org/10.1056/NEJMoa1300662DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4084652PMC
March 2014

Mesothelin-specific chimeric antigen receptor mRNA-engineered T cells induce anti-tumor activity in solid malignancies.

Cancer Immunol Res 2014 Feb;2(2):112-20

Abramson Cancer Center; University of Pennsylvania, Philadelphia, PA ; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA ; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

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http://dx.doi.org/10.1158/2326-6066.CIR-13-0170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932715PMC
February 2014

TCR affinity and specificity requirements for human regulatory T-cell function.

Blood 2012 Apr 7;119(15):3420-30. Epub 2012 Feb 7.

Department of Microbiology, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6160, USA.

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http://dx.doi.org/10.1182/blood-2011-09-377051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3325034PMC
April 2012

The inducible costimulator (ICOS) is critical for the development of human T(H)17 cells.

Sci Transl Med 2010 Oct;2(55):55ra78

Abramson Family Cancer Research Institute, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1126/scitranslmed.3000448DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282816PMC
October 2010

Steric shielding of surface epitopes and impaired immune recognition induced by the ebola virus glycoprotein.

PLoS Pathog 2010 Sep 9;6(9):e1001098. Epub 2010 Sep 9.

Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1001098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2936550PMC
September 2010

HIV sequence variation associated with env antisense adoptive T-cell therapy in the hNSG mouse model.

Mol Ther 2010 Apr 26;18(4):803-11. Epub 2010 Jan 26.

Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1038/mt.2009.316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862538PMC
April 2010

Adoptive immunotherapy: good habits instilled at youth have long-term benefits.

Immunol Res 2008 ;42(1-3):182-96

Abramson Family Cancer Research Institute, University of Pennsylvania, BRB II/III, Room 554, 421 Curie Boulevard, Philadelphia, PA, 19104-6160, USA.

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http://dx.doi.org/10.1007/s12026-008-8070-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3809041PMC
March 2009

Derivation and fluidity of acutely induced dysfunctional CD8+ T cells.

J Immunol 2008 Apr;180(8):5300-8

Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.4049/jimmunol.180.8.5300DOI Listing
April 2008

Addition of deoxynucleosides enhances human immunodeficiency virus type 1 integration and 2LTR formation in resting CD4+ T cells.

J Virol 2007 Dec 10;81(24):13938-42. Epub 2007 Oct 10.

Department of Pathology and Laboratory Medicine, Division of Transfusion Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://jvi.asm.org/cgi/doi/10.1128/JVI.01745-07
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http://dx.doi.org/10.1128/JVI.01745-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2168855PMC
December 2007

Immunogenicity of cytopathic and noncytopathic viral vectors.

J Virol 2006 Jul;80(13):6259-66

Thomas Jefferson University, Kimmel Cancer Center, 233 S. 10th Street, BLSB 730, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1128/JVI.00084-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1488949PMC
July 2006