Publications by authors named "G Coulibaly"

61 Publications

[Prevalence and risk factors associated with intradialytic hypotension in Sub-Saharan Africa: The case of Burkina Faso].

Ann Cardiol Angeiol (Paris) 2021 Feb 23. Epub 2021 Feb 23.

Service de néphrologie, centre hospitalier universitaire Yalgado Ouedraogo, Ouagadougou, Burkina Faso.

Aim: The aim of our study was to determine the prevalence and factors associated with intradialytic hypotension in our cohort of chronic hemodialysis patients.

Methods: This was a prospective monocentric study over a six-month period. Intradialytic hypotension was defined as a decrease in systolic blood pressure ≥ 20mmHg or a decrease in mean arterial pressure of 10mmHg associated with clinical events and the need for nursing interventions. The groups were compared using univariate analysis of variance.

Results: We included 48 patients and counted 3014 hemodialysis sessions. The mean age was 44.7±15 years. The prevalence of intradialytic hypotension was 12.4%, with cramps 20 (41.7%) as the main symptom. Factors associated with frequent intradialytic hypotension compared to the groups without intradialytic hypotension and with infrequent intradialytic hypotension were age (61±13 years, p=0.018), diabetes (33.3%, p=0.019), high body mass index (27, 3±7.8kg/m2, p=0.002), interdialytic weight gain ≥ 5% of baseline weight (66.7%, p=0.033), hourly ultrafiltration (800±275ml/h, p=0.037) and perdialytic feeding (33.3%, p=0.016). Low pre-dialysis diastolic blood pressure (72±13mmHg, p=0.012) and high baseline weight (73.9±17.5kg, p=0.028) were associated with frequent versus infrequent intradialytic hypotension.

Conclusion: Intradialytic hypotension is common in our context. Its prevention in at-risk patients is critical to reducing morbidity and mortality and improving quality of life.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ancard.2021.01.002DOI Listing
February 2021

Fluorescein diacetate and rapid molecular testing for the early identification of rifampicin resistance in Mali.

Int J Tuberc Lung Dis 2020 08;24(8):763-769

Unit of Mycobacteriology, Institute of Tropical Medicine Antwerp, Antwerp.

Non-conversion on auramine smear microscopy indicates a lack of treatment response, possibly associated with initial rifampicin-resistant tuberculosis (RR-TB). However, dead bacteria still stain positive and may be detected. Fluorescein diacetate smear microscopy (FDA) shows live mycobacteria only. Therefore, we studied the potential of 2-month (2M) FDA for the identification of initial RR-TB. Between 2015 and 2018, we enrolled new smear-positive pulmonary TB patients from five local centres in Bamako, Mali. After baseline screening, sputum samples were collected at 1M, 2M, 5M and 18M. We used B sequencing to identify initial RR-TB. Of 1359 patients enrolled, 1019 (75%) had B sequencing results. Twenty-six (2.6%, 95%CI: 1.7-3.7) had mutations conferring rifampicin resistance. Most frequent B mutations were located at the codons Asp435Val (42.4%) and Ser450Leu (34.7%). Among patients with initial RR-TB, 72.2% were FDA-negative at 2M ( 0.2). The positive and negative predictive value of 5M FDA for culture-based failure was respectively 20.0% and 94.7%. FDA did not identify the majority of patients with initial RR-TB or culture-based failure. As the full spectrum of mutations identified on sequencing was identified using Xpert, our data support its rapid universal implementation in Mali.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.5588/ijtld.19.0698DOI Listing
August 2020

[Task sharing in family planning in Burkina Faso: quality of services delivered by the delegate].

Pan Afr Med J 2020 5;36:69. Epub 2020 Jun 5.

Secrétariat Général du Ministère de la Santé, Burkina Faso.

Introduction: we conducted a pilot study for transferring skills for intrauterine device (IUD) insertion and implants to primary health care workers (PHCWs) as well as to provide injectable contraceptives to community health workers (CHWs) in 20 Health Centers in the Tougan Health District. This was aimed to increase access to contraceptive methods in Burkina Faso. Moreover, the purpose of this study was to assess the quality of family planning (PF) services offered by these delegated (PHCWs and CHWs).

Methods: we conducted a cross-sectional, descriptive, analytical study. Data collection was based on quantitative and qualitative methods. It included the 20 health centers in the study area and all providers (54) involved in contraceptive product supply (delegators and delegatees). Nineteen (19) recipients including 10 new contraceptive users were interviewed. The method of data collection included the observation of FP services and of the working environment, document review and individual interviews. Data were analyzed using Epi info 7 and Open Epi version 3.01. software. Chi-square test and Student's t-test were used to determine whether there was significant difference between the quality of PF services offered by the delegators and that of the delegatees.

Results: PF service quality score in the study area was 73% for the delegators' vs 69% for the delegates. There was no statistically significant difference between these scores. However, there was a statistically significant difference between the quality score of community health workers (75.8%) and the quality score of counselors (delegators; 87.5%) (P <0.05). It was the same for quality score determining who was eligible for implants. The quality score of PHCWs was higher than that of delegators: 79% for delegators, 64% for delegatees.

Conclusion: this purpose of this study was to improve the geographic coverage for long-acting contraceptive methods. Under certain conditions (skills-building, monitoring, coaching), it is possible to extend the transferring of skills for long-acting contraceptive methods to PHCWs as well as the provision of injectable contraceptives to CHWs, while maintaining a satisfactory level of FP service quality.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.11604/pamj.2020.36.69.18091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7380869PMC
December 2020

Red mud-activated peroxymonosulfate process for the removal of fluoroquinolones in hospital wastewater.

Water Res 2020 Oct 12;184:116171. Epub 2020 Jul 12.

Department of Civil and Environmental Engineering, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea. Electronic address:

In this study, a novel peroxymonosulfate (PMS) activation method, which combines a solid waste (i.e., red mud, RM) and a reducing agent (i.e., hydroxylamine, HA), for the oxidative degradation of fluoroquinolones (FQs; i.e., flumequine (FLU) and ciprofloxacin (CIP)) in hospital wastewater (HW) was developed. The addition of HA into the PMS/RM suspension significantly enhanced FLU removal, owing to its ability to enhance the Fe(III)/Fe(II) cycle on the RM surface. The results of the quenching experiments suggested the predominance of SO over OH in the PMS/RM/HA system. Moreover, owing to the greater reactivity between CIP and SO, CIP removal was more effective than FLU removal. Additionally, the liquid chromatography-mass spectroscopy (LC-MS) analysis revealed that the oxidation of CIP and FLU by PMS/RM/HA occurred via sequential and separate processes, involving ring cleavage, hydroxylation, decarbonylation, and defluorination. Surprisingly, the wastewater components exhibited contrasting effects on FLU removal in HW. Natural organic matter, nitrate and sulfate showed a slight impact on the removal performance of FLU, whereas chloride improved the oxidation extent. However, phosphate significantly inhibited the FLU removal because of its competitive binding at the RM surface and its scavenging effect towards SO. This inhibitory effect was overcome by increasing the PMS concentration and its sequential addition, thus guaranteeing successful mineralization of FLU in HW. These results show that the RM/HA system can be utilized to activate PMS for the removal of antibiotics in wastewater.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.watres.2020.116171DOI Listing
October 2020

Performance of Mali's biosafety level 3 laboratory in the external quality assessment in preparedness of laboratory accreditation and support to clinical trials.

Int J Mycobacteriol 2020 Jan-Mar;9(1):29-33

University Clinical Research Center-SEREFO-Laboratory, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali.

Background: The external quality assessment (EQA) or external quality control is an evaluation conducted by a certified external organization to inquire about the quality of the results provided by a laboratory. The primary role of EQA is to verify the accuracy of laboratory results. This is essential in research because research data should be published in international peer-reviewed journals, and laboratory results must be repeatable. In 2007, the University Clinical Research Center (UCRC's) biosafety level 3 (BSL-3) laboratory joined the EQA program with the College of American Pathologists in acid-fast staining and culture and identification of mycobacteria as per laboratory accreditation preparedness. Thus, after 11 years of participation, the goal of our study was to evaluate the performance of our laboratory during the different interlaboratory surveys.

Methods: We conducted a descriptive retrospective study to evaluate the results of UCRC mycobacteriology laboratory from surveys conducted during 2007 and 2017.

Results: Of the 22 evaluations, the laboratory had satisfactory (100% of concordance results) in 18 (81.8%) and good (80% of concordance results) in 4 (18.2%). Overall, the laboratory was above the commended/accepted limits of 75%.

Conclusion: So far, UCRC's BSL-3 performed well during the first 11 years of survey participation, and efforts should be deployed to maintain this high quality in the preparedness for laboratory accreditation and support to clinical trials.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.4103/ijmy.ijmy_5_20DOI Listing
April 2021

[Hemoglobinuria in children hospitalized in Ouagadougou: short term inpatient care and prognosis].

Pan Afr Med J 2019 26;34:165. Epub 2019 Nov 26.

Service de Pédiatrie Médicale, Centre Hospitalier Universitaire Pédiatrique Charles-de-Gaulle, Ouagadougou, Burkina Faso.

Introduction: The purpose of this study was to analyze the epidemiological, diagnostic, therapeutic and evolutionary features of hemoglobinuria in children hospitalized in the Pediatric University Hospital Charles de Gaulle, Ouagadougou.

Methods: We conducted a cross-sectional descriptive study over the period 01 July-31 December 2014. All children aged 0-15 years hospitalized in the Department of Medical Pediatrics of the Pediatric University Hospital Charles de Gaulle and diagnosed with macroscopic hemoglobinuria during the study period were enrolled.

Results: Thirty-eight patients were included in the study. Hospitalization rate for hemoglobinuria was 1.9%. The average age of patients was 80.8 ± 44.1 months (ranging from 21 to 168). The study involved 23 boys (60.5%) and 15 girls (39.5%). The major clinical signs were: fever (86.8%), dark urines like « coca cola » (86.8%), pallor (63.2%), hepatomegaly (50%). Glomerular filtration flow was less than 80 mL/min/1.73m in 23 patients (69.7%); 21 patients had Glucose-6-phosphate dehydrogenase (G6PD) deficiency. The main suspected causes of hemoglobinuria were: severe malaria, bacterial and viral infections, G6PD deficiency, biliary haemoglobinuric fever. Treatments included: artemisinin derivatives, antibiotics and antipyretics. One patient underwent dialysis.

Conclusion: Hemoglobinuria is a symptom mainly causing diagnostic problems in our context. It is a severe disorder which can result in acute renal failure (ARF).
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.11604/pamj.2019.34.165.14729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046116PMC
March 2020

Clinical, Paraclinical, and Evolutionary Profiles of Kidney Failure in Gold Miners Hospitalized in a Nephrological Service in a Sub-Saharan African Country.

Int J Nephrol 2020 14;2020:4282969. Epub 2020 Feb 14.

Centre Hospitalier Universitaire Sourô SANOU, Service de Néphrologie et Dialyse, Bobo-Dioulasso, Burkina Faso.

. The purpose of this preliminary study is to describe the clinical, paraclinical, and evolutionary profiles of gold miner patients with kidney failure hospitalized in the nephrology and haemodialysis service in the Yalgado Ouédraogo University Hospital of Ouagadougou (CHU-YO). . This was a longitudinal and descriptive study with a retrospective collection of data for the period from February 1, 2013, to March 31, 2018. Included were all gold miner patients who stayed and worked at an artisanal gold mining site for at least three months and who were diagnosed with acute or chronic kidney failure during hospitalization in the nephrology service. We collected sociodemographic, clinical, and paraclinical variables at admission and then three months later.

Results: We included 50 patients; all were male and the average age was 29.4 ± 7.7 years. All patients were exposed to mercury and/or cyanide for an average of 4.5 ± 2.8 years. The average consultation/referral time for patients at the CHU-YO was 25.4 ± 14.9 days. The average of creatininemia was 2338.0 ± 791.4 mol/L. Kidney failure was acute in five cases (10%) and chronic in the remaining 45 cases or 90%. Extrarenal purification was indicated in 43 cases (86%). It was not performed in nine of the 43 cases due to lack of financial resources for patients (six cases) or death prior to the onset of haemodialysis (three cases). Thirty-two of the 50 patients in the study (64% of cases) died.

Conclusion: Chronic kidney failure in gold miners appears to be common and late-managed. A prospective study of kidney disease and its causes at gold mining sites and surrounding areas will assess the extent of the problem in the country and better clarify the prevention of these diseases in our country.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1155/2020/4282969DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042529PMC
February 2020

Use of sodium dodecyl sulfate to improve tuberculosis sputum smear microscopy.

Glob Health Innov 2019 Nov 26;2(2). Epub 2019 Nov 26.

University of Sciences, Techniques and Technologies of Bamako (USTTB), Bamako, Mali.

Sputum smear microscopy (SSM), the most widely available tool for tuberculosis (TB) detection, has limited performance in paucibacillary patients and requires highly experienced technicians. The objective of this study was to determine whether the addition of sodium dodecyl sulfate (SDS), a detergent that thins sputum, at 4% and 10%, improves the detection of acid-fast bacilli (AFB), the clarity of slides, and the biosafety of the technique. Thirty participants with presumptive TB were enrolled. Three independent, blinded technicians examined the slides. Regular sputum concentrated AFB smear and sputum culture were used as standard control methods. Sputum culture was also performed before and after 10% SDS addition for safety analysis. We found that neither SSM with SDS 4% nor SSM with SDS 10% improved the test's performance. However, slides with 4% and 10% SDS, compared with slides prepared without SDS, had significantly better clarity scores. The 10% SDS-prepared sputum samples were all culture negative. While adding SDS detergent does not improve the performance of SSM slides, it does improve the clarity and biosafety. Where experienced technicians are scarce, especially in low resource settings, use of SDS may enhance the ease of slide reading in sputum smear microscopy.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.15641/ghi.v2i2.824DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6919652PMC
November 2019

Diabetes Mellitus among new tuberculosis patients in Bamako, Mali.

J Clin Tuberc Other Mycobact Dis 2019 Dec 1;17:100128. Epub 2019 Nov 1.

University Clinical Research Center (UCRC)-SEREFO-Laboratory, University of Sciences, Techniques and Technologies of Bamako (USTTB), Bamako, Mali.

Introduction: Diabetes Mellitus (DM) increases worldwide, mostly in low- and middle-income countries. In Mali, the prevalence in the adult population is estimated at 1.8%, but tuberculosis (TB) patients are not systematically screened. The goal of our study was to determine the prevalence of DM among newly diagnosed TB patients.

Methods: We conducted a cross sectional study and a pilot prospective cohort study in four health centers in Bamako. All patients underwent fasting capillary-blood glucose (FCBG) test at Day 0, and repeated after one-week of TB treatment. Venous FBG test was performed for discrepancies between the two FCBG results. Thereafter, FCBG was performed for pilot study at month-2 (M2) and M5 of TB treatment.

Results: Two hundred and one patients were enrolled in this study. Impaired fasting blood glucose was identified in 17 (8.5%), of whom 11 (5.5%) had DM (VFBG >7 mmol/L). Among patients with DM, seven (63.6%) had successful TB treatment outcome, versus 142 (74.7%) of those without DM ( = 0.64), and (OR: 1.69, 95%CI 0.47-6.02).

Conclusion: The prevalence of DM among TB patients in Bamako exceeds that of the general population and screening at TB diagnosis suffices to identify those with DM. Systematic screening of both diseases will allow better treatment.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jctube.2019.100128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6879999PMC
December 2019

[Anxiety and depression during chronic renal failure before end stage at the University hospital center Yalgado Ouedraogo of Ouagadougou (Burkina Faso)].

Nephrol Ther 2019 Dec 3;15(7):506-510. Epub 2019 Nov 3.

Service de psychiatrie, CHU de Yalgado Ouédraogo, 03 BP 7022 Ouagadougou, Burkina Faso.

Aim: We wanted to know the prevalence of depression and anxiety, as well as the associated factors in patients with chronic renal failure in Burkina Faso.

Patients And Methods: This was an analytical cross-sectional study conducted from February to May 2016. We included all adult patients with moderate or severe chronic renal failure. The diagnosis of anxiety and depression was made using the Hamilton scales. Identification of factors associated with both conditions required bi- and multivariate analyzes.

Results: The study involved 191 patients, with a mean age of 53.2±14.2 years and a sex ratio of 1.4. The prevalence of anxiety and depression was 42.4% and 66.5%, respectively. In 37.7% of cases, both anxiety and depression were noted. The mean age was 52.2±13.1 years for anxious patients and 53.5±13.3 years for the depressed. After multivariate analysis, female sex (odds ratio 2.2; adjusted P=0.014) was significantly associated with anxiety, and anxiety itself at depression (odds ratio 7.5; adjusted P<0.001).

Conclusion: Anxiety and depression are very common during moderate or severe chronic renal failure in Burkina Faso. In view of their potentially serious consequences, there is a definite interest in their early detection by the nephrologist, especially in the female patient, and for early management.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nephro.2019.07.329DOI Listing
December 2019

[Epidemiology of acute renal failure during dengue fever in the city of Ouagadougou].

Nephrol Ther 2020 Feb 25;16(1):27-32. Epub 2019 Oct 25.

Service de néphrologie et hémodialyse, CHU de Yalgado Ouédraogo, 03 BP 7022 Ouagadougou, Burkina Faso.

Aim: Describe acute renal failure during dengue fever in Ouagadougou, in a context of almost nonexistent african data on the subject.

Patients And Method: The study was cross-sectional and descriptive with a retrospective collection of data in 13 health structures. It concerned a period of 16 months. Included were suspected cases of dengue fever following the guidelines of the ministry of health and for whom an ARF was diagnosed. The acute renal failure and its severity were defined according to KDIGO's recommendations.

Result: Sixty-seven cases (sex ratio 2.7 ; mean age 39.6±16.7 years) of acute renal failure were noted among 316 dengue fever patients, or 21.2%. The mean of serum creatinine on admission was 440.7±504.2 μmol/L. The acute renal failure severity was classified at stage 3 in 29 cases, or 43.3%. The most common etiopathogenic factors were those responsible for renal hypoperfusion in 47 cases, or 70.2%; 14 cases of brown macroscopic hematuria, or 20.9%, were observed. Nine patients, or 13.4%, were taken in conventional acute hemodialysis. Six cases of death, a lethality rate of 9%, were observed.

Conclusion: The acute renal failure in our dengue fever patients population was very common, severe, and highly lethal. The prognosis should improve with early management. It would be even better to promote primary prevention through effective vector control.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nephro.2019.04.002DOI Listing
February 2020

Competitive fitness of .

Int J Mycobacteriol 2019 Jul-Sep;8(3):287-291

University Clinical Research Center, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali.

Background: While, bacteria resistance mutations can affect competitive fitness, given our multidrug-resistant (MDR) prevalence, we conducted this study to determine the impact of MDR on the competitive fitness of Mycobacterium tuberculosis (MTB) complex MDR strains. We conducted a cross-sectional study at the University Clinical Research Center (UCRC) from January to December 2017. New TB patients over aged of 18 were recruited at University teaching hospital and health reference centers of Bamako in USTTB Ethical committee approved protocols.

Methods: MDR and drug-susceptible (wild-type [WT]) MTB strains (T1 and Beijing) and MTB H37Rv were competed on solid media in UCRC's Tuberculosis Laboratory. Competitive and individual cultures were incubated for 14 days at 37°C with 7% CO2. Number of generation, generation time, and relative competitive fitness (W) of the strains were calculated. Data were analyzed with Epi-Info 7.1.5.2 software (CDC). P value was considered significant when it was <0.05. Scientific calculator (CS-82TL) was used for competitive fitness parameters calculations.

Results: We performed 24 competitive cultures and 10 individual cultures. In individual cultures, strains' generation number was for Beijing (WT: 4.60 and mutant MR: 4.40), T1 (WT: 2.69 and MR: 2.37), and H37Rv: 2.91. Generation number of WT strains was less than those of MDR strains in both individual and competitive culture. Relative competitive fitness was below 1 (W<1) in 83.3%.

Conclusion: MDR strains were less competitive than WT strains in 83.3% of cases. Resistant mutation impacts bacteria fitness.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.4103/ijmy.ijmy_97_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6918047PMC
January 2020

An Integrated Approach to Control Soil-Transmitted Helminthiasis, Schistosomiasis, Intestinal Protozoa Infection, and Diarrhea: Protocol for a Cluster Randomized Trial.

JMIR Res Protoc 2018 Jun 12;7(6):e145. Epub 2018 Jun 12.

Swiss Tropical and Public Health Institute, Basel, Switzerland.

Background: The global strategy to control helminthiases (schistosomiasis and soil-transmitted helminthiasis) emphasizes preventive chemotherapy. However, in the absence of access to clean water, improved sanitation, and adequate hygiene, reinfection after treatment can occur rapidly. Integrated approaches might be necessary to sustain the benefits of preventive chemotherapy and make progress toward interruption of helminthiases transmission.

Objective: The aim of this study was to assess and quantify the effect of an integrated control package that consists of preventive chemotherapy, community-led total sanitation, and health education on soil-transmitted helminthiasis, schistosomiasis, intestinal protozoa infection, and diarrhea in rural Côte d'Ivoire.

Methods: In a first step, a community health education program was developed that includes an animated cartoon to promote improved hygiene and health targeting school-aged children, coupled with a health education theater for the entire community. In a second step, a cluster randomized trial was implemented in 56 communities of south-central Côte d'Ivoire with 4 intervention arms: (1) preventive chemotherapy; (2) preventive chemotherapy plus community-led total sanitation; (3) preventive chemotherapy plus health education; and (4) all 3 interventions combined. Before implementation of the aforementioned interventions, a baseline parasitologic, anthropometric, and hygiene-related knowledge, attitudes, practices, and beliefs survey was conducted. These surveys were repeated 18 and 39 months after the baseline cross-sectional survey to determine the effect of different interventions on helminth and intestinal protozoa infection, nutritional indicators, and knowledge, attitudes, practices, and beliefs. Monitoring of diarrhea was done over a 24-month period at 2-week intervals, starting right after the baseline survey.

Results: Key results from this cluster randomized trial will shed light on the effect of integrated approaches consisting of preventive chemotherapy, community-led total sanitation, and health education against infections with soil-transmitted helminths, schistosomes, an intestinal protozoa and prevention of diarrhea in a rural part of Côte d'Ivoire.

Conclusions: The research provided new insights into the acceptability, strengths, and limitations of an integrated community-based control package targeting helminthiases, intestinal protozoa infections, and diarrhea in rural communities of Côte d'Ivoire. In the longer term, the study will allow determining the effect of the integrated control approach on infection patterns with parasitic worms and intestinal protozoa, diarrheal incidence, anthropometric measures, and hygiene-related knowledge, attitudes, practices, and beliefs.

Trial Registration: International Standard Randomized Controlled Trial Number (ISRCTN): 53102033; http://www.isrctn.com/ISRCTN53102033 (Archived by WebCite at http://www.webcitation.org/6wpnXEiHo).

Registered Report Identifier: RR1-10.2196/9166.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.2196/resprot.9166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6019843PMC
June 2018

Epidemiology of intestinal parasite infections in three departments of south-central Côte d'Ivoire before the implementation of a cluster-randomised trial.

Parasite Epidemiol Control 2018 May 18;3(2):63-76. Epub 2018 Feb 18.

Unité de Formation et de Recherche Biosciences, Université Félix Houphouët-Boigny, Abidjan, Côte d'Ivoire.

Hundreds of millions of people are infected with helminths and intestinal protozoa, particularly children in low- and middle-income countries. Preventive chemotherapy is the main strategy to control helminthiases. However, rapid re-infection occurs in settings where there is a lack of clean water, sanitation and hygiene. In August and September 2014, we conducted a cross-sectional epidemiological survey in 56 communities of three departments of south-central Côte d'Ivoire. Study participants were invited to provide stool and urine samples. Stool samples were examined for helminth and intestinal protozoa infections using the Kato-Katz technique and a formalin-ether concentration method. Urine samples were subjected to a filtration method for the diagnosis of . Information on sociodemographic characteristics, knowledge, attitude, practices and beliefs with regard to hygiene, sanitation and intestinal parasitic diseases were collected using a questionnaire administered to household heads. Multivariable logistic regression models were employed to analyse associations between parasite infections and risk factors. Overall, 4,305 participants had complete parasitological and questionnaire data. Hookworm was the predominant helminth species (21.2%), while , , and showed prevalences below 10%. Infections with pathogenic intestinal protozoa (e.g. /. and ) were similarly prevalent in the three departments. Hookworm infection was associated with open defecation and participants' age and sex. infection was negatively associated with the use of tap water at home (odds ratio (OR) = 0.66;  = 0.032). Disposal of garbage in close proximity to people's home was positively associated with . (OR = 1.30;  = 0.015). Taken together, helminth and intestinal protozoa infections affected a considerable proportion of rural dwellers in south-central Côte d'Ivoire at the onset of a cluster-randomised intervention trial. Our results will serve as baseline to monitor the effect of a package of interventions, including preventive chemotherapy, sanitation and health education on re-infection with helminths and intestinal protozoa.

Trial Registration: ISRCTN53102033 (date assigned: 26 March 2014).
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.parepi.2018.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952672PMC
May 2018

The most frequent complex families in mali (2006-2016) based on spoligotyping.

Int J Mycobacteriol 2017 Oct-Dec;6(4):379-386

University Clinical Research Center-SEREFO-Laboratory, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali.

Background: To identify strains of Mycobacterium tuberculosis complex (MTBc) circulating in Bamako region during the past 10 years.

Methods: From 2006 to 2016, we conducted a cross-sectional study to identify with spoligotyping, clinical isolates from tuberculosis (TB)-infected patients at different stages of their treatments in Bamako, Mali.

Results: Among the 904 suspected TB patients included in the study and thereafter tested in our BSL-3 laboratory, 492 (54.4%) had MTBc and therefore underwent spoligotyping. Overall, three subspecies, i.e., MTB T1 (31.9%) and MTB LAM10 (15.3%) from lineage 4 and M. africanum 2 (16.8%) from lineage 6 were the leading causes of TB in Bamako region during the past 10 years. Other spoligotypes such as MTB T3, MTB Haarlem 2, MTB EAI3, and MTB family 33 were also commonly seen from 2010 to 2016.

Conclusion: This study showed a high genetic diversity of strains isolated in Bamako region and highlights that M. tuberculosis T1 strain was the most prevalent. Furthermore, the data indicate an increasing proportion of primary drug resistance overtime in Bamako.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.4103/ijmy.ijmy_140_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5759756PMC
September 2018

[Malaria and intestinal parasitosis in pregnant woman at Abobo district (Abidjan, Côte d'Ivoire)].

Bull Soc Pathol Exot 2017 May 1;110(2):85-91. Epub 2017 Mar 1.

UFR Biosciences, Laboratoire de zoologie et biologie animale, URF de parasitologie et d'écologie parasitaire, Université Félix Houphouët-Boigny de Cocody-Abidjan, 22 BP 582, Abidjan 22, Ivory Coast.

A prospective study was carried out from 2010 to 2012 at the Hôpital Général d'Abobo (HGA) in Abidjan, in order to determine the impact of infectious and parasitic diseases on child cognitive development. Blood samples were examined by means of thick drop and blood smear; as for stool by direct examination and concentration by formalin-ether method. We evaluated the prevalence, the parasite load of malaria and gastrointestinal parasites; then we investigated the risk factors for these disorders. Overall, 331 pregnant women in the last trimester of their pregnancy were enrolled. The plasmodic index was 3.9% with infestation specific rates of P. falciparum from 100%. Concerning digestive protozoa, it has been observed 71.3% of nonpathogenic, against 9.7 % of pathogens, either an overall prevalence of 51.4% of digestive parasites. The calculated average parasitic loads revealed 3089.2 tpz/μl of blood (95 % CI: 591.1-5587.3) for malaria, 6.5 eggs per gram of stool (95 % CI: 0.4-13.4) for intestinal helminths and one parasite by microscopic field for protozoa (common infestation). It has been shown that the occurrence of malaria has been linked to the non-use of impregnated mosquito nets (x = 0.012; p = 0.018), not to age. No link could be established between the presence of digestive parasites and the age of pregnant women, or socioeconomic conditions (level of education, profession, type of toilet). Malaria is less common in pregnant women while the rate of digestive parasites remains high.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s13149-017-0552-3DOI Listing
May 2017

Screening new tuberculosis patients in Mali for rifampicin resistance at 2months.

Int J Mycobacteriol 2016 Dec 11;5 Suppl 1:S42-S43. Epub 2016 Nov 11.

Mycobacteriology Unit, Institute of Tropical Medicine Antwerp, Antwerp, Belgium.

Objective/background: The recent call for universal drug susceptibility testing (DST) for all tuberculosis (TB) patients will be difficult to meet in settings where Xpert rollout is limited, such as low prevalence of HIV and Multi-drug Resistant Tuberculosis (MDR) settings. As recommended by World Health Organization (WHO) guidelines, the success of TB treatment is measured by Ziehl-Neelsen (ZN) microscopy or auramine-rhodamine fluorescent microscopy (FM) on sputum, in which conversion to negative smear at 2months (M) is an important predictor of treatment success, defined as a negative smear at 5M. The sputum smear that fails to convert to negative at 5M are screened for rifampicin resistance. We tested in a prospective study whether an early screen for rifampicin resistance, based on FM results at 2M, could detect MDR patients early, rather than screening all patients with GeneXpert MTB/Rif at baseline.

Methods: Between February 2015 and August 2016, we enrolled new TB patients in an IRB-approved prospective cohort study at four health centers in Bamako district. Fresh sputum samples were collected at 2M and 5M to measure FM smear conversion. Patients who failed to show a decline in FM positivity at 2M (moderate or many Acid Fast Bacilli (AFB)) had their sputum tested in GeneXpert to detect rifampicin resistance. Patients who had any AFB seen at 5M were also tested using GeneXpert.

Results: Of the 570 patients who were enrolled in the study, 22 (3.8%) died and 27 (4.7%) were lost to follow-up. The prevalence of HIV and TB coinfection was 12.4%, and 65.6% of the patients were male. At 2M, 32 out of 429 patients still had moderate or many AFBs in FM, and were screened by Xpert, of whom 5 (15.6%) tested rifampicin-resistant and were referred for MDR treatment. Of the 310 patients who completed 5M of treatment, 35 (11.3%) met the definition of failure (few or moderate AFB in FM) and had their sputum tested in Xpert; moreover, four (11.4%) demonstrated rifampicin resistance. In total, 67 (21.6% of 310) patients were screened by Xpert, of whom nine were detected to have MDR (or 13.4% of those screened).

Conclusion: Although we cannot exclude additional MDR patients having been missed by our screening strategy, our screening algorithm at 2M detected five out of nine MDR patients. Detecting patients at 2M allowed for earlier referral, and potentially less acquired drug resistance and lower mortality. This strategy may be advantageous while awaiting further rollout of Xpert machines that will permit universal DST.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijmyco.2016.09.052DOI Listing
December 2016

[Current situation of primary prophylaxis with isoniazid (INH) in children who are contacts of patients with bacillary pulmonary tuberculosis in Abidjan (Cote d'Ivoire)].

Rev Pneumol Clin 2016 Dec 21;72(6):340-345. Epub 2016 Oct 21.

Service de pneumophtisiologie, CHU Treichville, BP V 03 Abidjan, Cote d'Ivoire.

Introduction: The National tuberculosis program (NTP) in Ivory Coast recommends that children under 5 years living in a family environment with contagious tuberculosis patients, should receive Prophylactic treatment with INH (PTI), whatever the result of the tuberculin skin test (positive or negative) and their BCG status (vaccinated or not), at a dose of 5mg/kg/day for 6 months. We conducted this study to check the implementation of this recommendation in three support services of tuberculosis in Abidjan, the economic capital.

Material And Method: We conducted a multicenter, cross-sectional and descriptive study over 3 years (2011-2013), on consented patients, adolescents and adults aged at least 15 years, with a first episode of infectious pulmonary tuberculosis, in order to look for information on the INH prophylaxis in children under 5 years living under the same roof. We made patients interviews during their visit for bacteriological sputum controls at the second month of TB treatment.

Results: Of a total of 412 patients (53% males and 47% females) with a mean age of 34.5 years and with a low level of instruction (66.5%), we noticed 639 children under 5 years living under the same roof with them. Information on the screening of contact children was given to 71% of interviewed patients (291/412). Of the 339 children examined among 639 contacts, 234 (69%) had received only an intradermoreaction (IDR) and PTI was finally administered to 64% of them (217/339).

Conclusion: High proportion of contact children under 5 not examined is a major concern for the NTP and a missed opportunity to prevent additional cases of tuberculosis among children.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pneumo.2016.08.003DOI Listing
December 2016

[Cutaneous manifestations in patients on chronic hemodialysis in a developing country].

Pan Afr Med J 2016 31;24:110. Epub 2016 May 31.

Service de Néphrologie et Hémodialyse, Ouagadougou, Burkina Faso; Université de Ouagadougou, Burkina Faso.

Our study aims to highlight the most common skin disorders in patients on chronic hemodialysis at the University Hospital Yalgado Ouédraogo (CHU-YO) in Ouagadougou. The study, of transverse type descriptive, carried out of September 15 to December 31, 2014, is unrolled with the CHU-YO. This descriptive transversal study was conducted at the CHU-YO from September 15 to December 31, 2014. It involved patients who had been on chronic dialysis for at least 3 months. The frequency of hemodialysis sessions was one every five days. The significance level of statistical tests was defined as the probability p ≤ 0.05. Eighty-five patients (61.1% men and 38.9% women) with an average age of 42.1 years were included in the study. The mean duration of hemodialysis was 31.9 months. The success rate of biological examinations varied from 7,4 to 85,3%. Eighty patients (85,3%) had at least one cutaneous manifestation. Cutaneous xerosis (67.4%), pruritus (45.3%), and hyperpigmentation (23.2%) were the most frequent skin manifestations that may be specific of hemodialysis. Guttate hypomelanosis (11.6%), prurigo (11.6%) and folliculitis (8.4%) were the main non-specific skin manifestations. Skin involvement was frequent but did not seem related to seniority in hemodialysis. In Ouagadougou, bad hemodialysis conditions and a hot, dry environment promote such conditions, especially xerosis and pruritus. A better subvention of health care could help to reduce the prevalence of skin diseases and to improve the quality of life of our patients on chronic hemodialysis.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.11604/pamj.2016.24.110.8639DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5012827PMC
February 2017

[Factors associated with depressive symptoms in chronic hemodialysis patients of centre hospitalier universitaire Yalgado Ouédraogo (Burkina Faso)].

Nephrol Ther 2016 Jul 23;12(4):210-4. Epub 2016 Feb 23.

Service de psychiatrie, CHU Yalgado Ouédraogo, 03 BP 7022, Ouagadougou, Burkina Faso.

Objective: To determine the factors associated with depressive symptoms in chronic hemodialysis patients at centre hospitalier universitaire Yalgado Ouédraogo de Ouagadougou (CHU-YO).

Patients And Methods: The study was cross sectional and descriptive, from June 2nd to July 30th, 2014. We included chronic hemodialysis patients of CHU-YO. The frequency of hemodialysis sessions was of every four to five days. The French version of Hamilton depression psychometric scale was used to assess depressive symptoms. The factors associated with depression were identified after descriptive and explanatory analysis.

Results: Depressive symptoms were identified in 140 of the 162 patients included in the study, or a prevalence of 86.4%. The average age of the 140 patients was 38.9±12.9years. In bivariate analysis, the risk of having depressive symptoms was 1.5 times for women, 1.7 times for patients with severe anemia, 1.5 times for hemodialysis catheter holders, 1.8 both in case of duration in hemodialysis less than six months. In multivariate analysis, gender and duration in hemodialysis were factors associated with the occurrence of depressive symptomatology.

Conclusion: Our study confirms the high frequency of depressive symptoms in patients on hemodialysis. To improve the overall care of hemodialysis patients, we suggest routine screening for depressive symptoms and specific support.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nephro.2015.12.004DOI Listing
July 2016

[Perinatal asphyxia and acute renal insufficiency in Ouagadougou].

Arch Pediatr 2016 Mar 5;23(3):249-54. Epub 2016 Feb 5.

Unité de formation et de recherche en sciences de la santé, Ouagadougou, Burkina Faso; Service de pédiatrie médicale, centre hospitalier universitaire pédiatrique Charles-de-Gaulle, Ouagadougou, Burkina Faso.

Aim: This study aimed to analyze acute renal failure in perinatal asphyxia (PNA) of term newborns in a sub-Saharan urban health center.

Patients And Methods: The study was prospective, conducted from 1st June to 30th November 2013 on term newborns hospitalized at the centre hospitalier universitaire pédiatrique Charles-de-Gaulle for PNA. Renal insufficiency (RI) was defined by a serum creatinine greater than or equal to 90 μmol/L.

Results: Eighty-five PNA cases were included, or 19.8% of newborns hospitalized in the study period. The sex ratio was 2.1. Thirty-eight newborns (44.7%) had RI. Their creatinine averaged 153.8±96.6 μmol/L. Twenty-six of 38 (68.4%) had brain damage in Sarnat stage 2 and 12 (31.6%) stage 3. Twelve newborns with RI (31.6%) had seizures. Transfontanellar echography revealed an abnormality in 30 cases (78.9%) of RI. Of the 38 newborns with renal failure, albuminuria was found in 21 cases (65.2%) and leukocyturia in 28 cases (73.7%). Renal function improved in 86.1% of cases. Newborns with initially normal serum creatinine had no RI during hospitalization. Six newborns (7.1%) died.

Conclusion: This study showed that acute RI is common during PNA most particularly in newborns with severe neurological impairment. In our context, earlier support for women in labor could help prevent PNA and therefore newborn acute RI.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.arcped.2015.12.002DOI Listing
March 2016

[Multidrug resistant tuberculosis among health personnel in Côte d'Ivoire].

Rev Pneumol Clin 2016 Apr 2;72(2):142-6. Epub 2015 Dec 2.

Service de pneumologie, CHU Cocody, Abidjan, Côte d'Ivoire.

Unlabelled: Multidrug resistance tuberculosis (MDR-TB) of health workers raises the question of hospital-borne transmission of infection.

Observations: We report 4 cases of MDR-TB confirmed at the health workers over a period of 8 years (January, 2005 to December 2012), in the 2 services of pulmonology from Abidjan to Côte d'Ivoire). It was about young grown-up patients (aged between 28 and 39 years), all HIV negatives, in a no-win situation of antituberculosis treatment (3 patients/4). The most concerned staffs were the male nurses (2/4). Two agents worked in general hospital and the only one in a pulmonology department at the time of the diagnosis. The tuberculosis was of lung seat with bilateral radiographic hurt (3/4) and multiples excavations (4/4). The case index, when it was identified (2/2), was a family case. Among 3 agents who benefited from a second line treatment, 1 died further to an extensive drug resistance and 2 are declared to be cured. The fourth died before the beginning of the treatment. These cases of cure were in touch with a premature care.

Conclusion: Multidrug resistant tuberculosis at the health workers could have a negative impact on the antituberculosis fight imposing rigorous measures of infection control and better implication of the occupational medicine.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pneumo.2015.09.006DOI Listing
April 2016

High Prevalence of Opaline Silica in Urinary Stones From Burkina Faso.

Urology 2015 Dec 1;86(6):1090-5. Epub 2015 Oct 1.

APHP, Service des Explorations Fonctionnelles, Hôpital Tenon, Paris, France; INSERM, UMR S 1155, Hôpital Tenon, Paris, France.

Objective: To underline peculiar composition of kidney stones and to propose an epidemiologic study of urinary stones in West African countries, where epidemiologic studies are scarce. Only few data are available regarding stone composition in sub-Saharan countries. Recently, a set of 100 stones consecutively removed by surgery in the Department of Urology of the University Hospital of Ouagadougou in Burkina Faso were collected for physical analysis, which provided the opportunity to obtain an epidemiologic profile of stone composition in this country.

Materials And Methods: A total of 100 stones from 64 men, 22 women, 10 boys, and four girls were analyzed by morphologic examination, infrared spectroscopy, and electron microscopy in our laboratory. The results were considered by sex and separately for adults and children.

Results: Sixty-five percent of the 100 stones contained calcium oxalate as the main component. Interestingly, the second main component was opaline silica (18%). Furthermore, opaline silica was identified in any proportion in 48% of the stones. The prevalence was sex and age dependent. Opaline silica was detected as the main component in 42% of the nuclei, which underlines its role as one of the main components involved in the initiation of calculi in this country.

Conclusion: For the first time, a dramatically high occurrence of a "scarce" urinary stone component, namely opaline silica, was reported in a series of consecutive calculi from a single country. We propose that a regular consumption of clay could be the origin of this phenomenon in these populations.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.urology.2015.06.068DOI Listing
December 2015

[Ivory Coast physician's knowledge and attitudes about smoking in patients with tuberculosis].

Rev Mal Respir 2015 May 30;32(5):513-8. Epub 2014 Aug 30.

Service de pneumo-phtisiologie, CHU de Treichville, BPV 3 Abidjan, Côte d'Ivoire.

Introduction: Smoking promotes, among other health problems, the development of tuberculosis and the discovery of a case of tuberculosis can therefore be an opportunity for tobacco control interventions.

Methods: We conducted a prospective study evaluating the knowledge of 37 Ivorian physicians (32 men and 5 women with 5 active smokers) on the relationship between smoking and tuberculosis and their attitudes to smoking tuberculous patients between February and August 2012 using an anonymous self-administered questionnaire.

Results: The response rate to the questionnaire was 88.1%. Among them, 70.3% of Ivorian physicians knew that smoking increased the incidence of tuberculosis, 75.7% said that forms of tuberculosis were more severe in smokers and about 27% thought that the cure rate of tuberculosis was lower in smokers. No significant difference was observed according to respondents' smoking status, or gender. Patients' smoking status was always assessed by 64.9% of physicians and by 78.4% in patients with tuberculosis, again not differing by physicians' smoking status or gender. The risks of smoking were always explained to patients with active pulmonary tuberculosis by 43.2% and benefits of stopping smoking ware always described in 35.1%. An intervention for smoking cessation was systematically offered to smokers having tuberculosis by 59.4% of physicians and 8.1% offered medication for smoking cessation.

Conclusion: These results strongly support the need to reinforce physician behaviors to address smoking in patients with tuberculosis in Ivory Coast.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.rmr.2014.04.105DOI Listing
May 2015

[Prevalence of albuminuria in children from 5 to 15 years in the town of Kaya (Burkina Faso)].

Mali Med 2014 ;29(4):43-49

Service de Néphrologie et Hémodialyse, CHU Yalgado Ouédraogo, 03 BP 7022 Ouagadougou, Burkina Faso.

Introduction: Albuminuria, an important marker of kidney damage, is still insufficiently studied in sub-Saharan Africa. The aim of this study is to describe the epidemiology of albuminuria in the town of Kaya in Burkina Faso.

Methods: We conducted a cross-sectional study in the town of Kaya. Simple random sampling was done. It concerned all households with children 5-15 years old of urban area of the town of Kaya. Selected children or their parents were interviewed. Anthropometric measurements and urinary samples were performed.

Results: Two hundred six children (113 girls and 93 boys) participated in the study. Albuminuria was found in 18 children whether 8.7% of cases. The mean systolic and diastolic blood pressures of children with albuminuria (107.2 ± 13.6 and 74.7 ± 11.4 mm Hg) were not significantly different from those of children without albuminuria (110.3 ± 14 and 73.1 ± 11.5 mmHg). Sociodemographic factors were not associated with the occurrence of albuminuria in children.

Discussion: The prevalence of albuminuria in the strip involved nearly a tenth of children, which is important.

Conclusion: The results of this study are a first population database of kidney disease in the country. The study should be completed by the identification of cases of persistent albuminuria in this population.
View Article and Find Full Text PDF

Download full-text PDF

Source
January 2014

[Management of end-stage kidney failure: a challenge for the countries of sub-Saharan Africa example of mineral and bone disorders in Burkina Faso].

Med Sante Trop 2013 May;23(2):193-6

Service de néphrologie et hémodialyse, CHU Yalgado Ouédraogo, 03 BP 7022, Ouagadougou, Burkina Faso.

Introduction: Meeting treatment targets for dialysis is a seemingly impossible challenge for most countries of sub-Saharan Africa. To assess this problem, we conducted this study of mineral and bone disorders in subjects undergoing hemodialysis at the Ouagadougou hemodialysis unit, the only such unit in Burkina Faso.

Patients And Methods: This cross-sectional descriptive study was conducted in January 2010. We included patients on hemodialysis for at least three months who had some minimal predialysis laboratory results available. The KDIGO guidelines served as our reference. Dialysis sessions lasted 5 h and took place once every five days. The statistical analysis of the data was performed with PASW statistical software, version 18 for Windows.

Results: The study included 32 of the 53 patients in the unit: 19 men and 13 women with a mean age of 43.5 ± 12.7 years. Their mean serum levels were 2.2 ± 0.2 mmol/L for calcium, 1.4 ± 0.5 mmol/L for phosphorus, 934 ± 887.4 pg/mL for intact parathyroid hormone and 193.4 ± 125.7 IU/L for total alkaline phosphatases. No patient reached the target for all three of the first three indicators. Patients with parathyroid hormone ≥ 800 pg/mL (n = 14) had a serum phosphorus (1.6 ± 0.6 vs 1.2 ± 0.4; p = 0.044) and alkaline phosphatases (287.5 ± 100.5 vs 120.2 ± 90; p < 0.001), significantly higher than those whose parathyroid hormone level was < 800 pg/mL.

Conclusions: The bone and mineral status of our hemodialysis patients is worrisome and is due to suboptimal treatment conditions. The risk of deaths is high. Subsidies sufficient to provide adequate care would reduce these problems, which have, we note, an ethical dimension.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1684/mst.2013.0178DOI Listing
May 2013

[Effects of war on control of tuberculosis in Côte d'Ivoire from 2002 to 2007].

Rev Pneumol Clin 2013 Oct 23;69(5):237-43. Epub 2013 May 23.

Service de pneumo-phtisiologie, CHU de Treichville, BPV 3, Abidjan, Côte d'Ivoire. Electronic address:

Objectives: To specify consequences of armed conflict in Côte d'Ivoire from 2002 to 2007 on treatment outcomes of new cases of smear-positive pulmonary tuberculosis (PTB+) and retreatment cases.

Methodology: Retrospective analysis of treatment outcomes and reprocessing notified to the National Program against Tuberculosis from 2001 to 2008.

Results: Totally, 7,4232 cases of TPM+ and 5094 cases of reprocessing had been declared during the war period in Côte d'Ivoire. The global average rate of therapeutic success was 72% with a lower average rate of success in retreatment in Center, Northern et Western (CNO) zone (54%) than in Southern zone (73%). The average rate of lost sight was higher in CNO zone than in the South with respectively 27% and 11%. The average rate of success in retreatment was 60% on the national level with a lower rate in CNO zone (48%) than in the South zone (62%) and the average rate of lost sight in retreatment was higher in CNO zone than in the South zone (28% versus 16%).

Conclusion: Our results show that there was no early epidemic of tuberculosis during the armed conflict in Côte d'Ivoire which has although severely disrupted activities of tuberculosis management in ex-nongovernmental zone.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pneumo.2013.04.001DOI Listing
October 2013

[Prevalence of proteinuria in children followed-up for HIV infection at Pediatric University Hospital Charles-de-Gaulle (CHUP-CDG) of Ouagadougou].

Bull Soc Pathol Exot 2013 Feb 12;106(1):13-7. Epub 2013 Jan 12.

Service de néphrologie et hémodialyse, CHU Yalgado-Ouédraogo, Ouagadougou, Burkina Faso.

In subjects infected with HIV, proteinuria could represent a marker of HIV associated nephropathy (HIVAN), the most important cause of chronic renal failure in them. To determine the prevalence of proteinuria in children with HIV infection and to improve the screening of renal disease for these children in our country, we conducted a descriptive cross-sectional study over a 3-month period. We included 122 children (0-14 years old) with HIV infection followed at CHUP-CDG. Proteinuria was calculated using the first morning urine sample by dipstick test (significant for a "+" or more). Statistical tests were significant for p < 0.05. The 122 children (121 HIV1 and 1 HIV2) comprised of 64 boys and 58 girls. Eighteen (14.8%) (14 boys and 4 girls) had proteinuria (1 or 2 "+"). The mean age of patients with proteinuria was 10.4 ± 3.3 years. None of the children were hypertensive. All were infected with HIV1. Proteinuria was associated with microscopic hematuria in six cases. The average CD4 count was 21 ± 8% versus 23 ± 10% in 42 patients without proteinuria (p = NS). The mean serum creatinine in patients with proteinuria was 47 ± 29 μmol/l. Three of them had acute renal failure. All patients with proteinuria had antiretroviral treatment (ARV) since 40 ± 24 months versus 36 ± 26 months in 98 patients without proteinuria. No treatment included tenofovir, indinavir, or converting enzyme inhibitor. The prevalence of proteinuria in our sample is lower than that reported by other African writers in untreated subjects. This fact suggests a nephroprotection of ARV in our patients probably treated early and effectively. However, microalbuminuria, a possible early marker of HIVAN, has not been evaluated by our study. Studies of the prevalence of microalbuminuria in children infected with HIVand treated with ARVs in Sub-Saharan African countries should be encouraged. They would help to determine the relevance in these children of research routinely of microalbuminuria and to screen and precociously take care of a possible HIVAN or other chronic glomerulopathy.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s13149-012-0270-9DOI Listing
February 2013

[Simvastatin indused chylothorax].

Rev Pneumol Clin 2012 Feb 26;68(1):50-3. Epub 2011 Aug 26.

Service de pneumo-phtisiologie, CHU de Treichville, Abidjan, Côte d'Ivoire.

Chylothorax is a rare disorder occurring most often in aftermath of a thoracic surgery or during cancer of mediastinum. We report the clinical history of the world's second case of chylothorax which appeared during treatment with simvastatin.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pneumo.2011.06.008DOI Listing
February 2012

[Dent's syndrome. Nephrology follow-up of four patients of the same family].

Nephrol Ther 2012 Apr 28;8(2):92-5. Epub 2011 Sep 28.

Unité de formation et de recherche en sciences de la santé de l'université de Ouagadougou, BP 7021, Ouagadougou, Burkina Faso.

Dent's syndrome is a rare inherited tubulopathy. Factors influencing renal function in this disease are not well known. The aim of our study is to investigate the evolution of the Dent's syndrome in renal plan. The study was retrospective and conducted in 2006, concerning four brothers. The genetic defect was a mutation S244L missense in exon 6 of gene CLCN5. Various parameters were studied. Patients were 8.5 to 21-years-old at the beginning of the follow-up. Two of them had chronic renal insufficiency (CRI) which evolved, at least 7 years of moderate to terminal stage. Tubular signs were made of hypokalemia, hypercalciuria, hypophosphatemia and proteinuria mostly β2 microglobulin. Improvement of these abnormalities was obtained with symptomatic treatment which has not always been well tolerated. A case of beginner nephrocalcinosis was observed. There was size and weight delay at the beginning of patient monitoring. Dent's syndrome may be complicated by CRI. It seems to appear in the second decade of life and hypercalciuria would contribute to it. Our CRI patients had significant bone disease. The hypercalciuria and proteinuria are factors over which we try to act. Clinical trials are needed to evaluate the efficacy of treatment on the reduction of CRI or its progression by reducing these factors in patients with Dent's syndrome.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nephro.2011.07.405DOI Listing
April 2012