Francois Lamontagne

Francois Lamontagne

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Francois Lamontagne

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Prognostic Value of Glial Fibrillary Acidic Protein in Patients With Moderate and Severe Traumatic Brain Injury: A Systematic Review and Meta-Analysis.

Crit Care Med 2019 Jun;47(6):e522-e529

CHU de Québec - Université Laval Research Center, Population Health and Optimal Health Practices Research Unit (Trauma - Emergency - Critical Care Medicine), Université Laval, Québec City, QC, Canada.

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http://dx.doi.org/10.1097/CCM.0000000000003728DOI Listing
June 2019

New filovirus disease classification and nomenclature.

Nat Rev Microbiol 2019 May;17(5):261-263

World Health Organization Regional Office for Africa, Brazzaville, Democratic Republic of the Congo.

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http://dx.doi.org/10.1038/s41579-019-0187-4DOI Listing
May 2019

Anti-Ebola therapy for patients with Ebola virus disease: a systematic review.

BMC Infect Dis 2019 May 2;19(1):376. Epub 2019 May 2.

Department of Critical Care Medicine, Sunnybrook Health Sciences Centre and Interdepartmental Division of Critical Care Medicine and Institute for Health Policy, Management, and Evaluation, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1186/s12879-019-3980-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6498552PMC
May 2019

Determinants of Depressive Symptoms at One Year after Intensive Care Unit Discharge in Survivors of ≥7 Days of Mechanical Ventilation: Results from the RECOVER Program - a Secondary Analysis of a Prospective Multi-Centre Cohort Study.

Chest 2019 May 15. Epub 2019 May 15.

Interdepartmental Division of Critical Care, University of Toronto, Toronto, Canada; Department of Medicine, Interdepartmental Division of Critical Care Medicine, Toronto General Research Institute, Institute of Medical Science, University Health Network, University of Toronto, Toronto, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S00123692193104
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http://dx.doi.org/10.1016/j.chest.2019.04.104DOI Listing
May 2019

Vitamin C for the critically ill: Is the evidence strong enough?

Nutrition 2019 Apr 22;60:185-190. Epub 2018 Oct 22.

Department of Intensive Care Medicine, Faculty of Medicine and Health Sciences, Sherbrooke University Hospital, Sherbrooke, Québec, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S08999007183066
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http://dx.doi.org/10.1016/j.nut.2018.10.009DOI Listing
April 2019

Vitamin C Administration to the Critically Ill: A Systematic Review and Meta-Analysis.

JPEN J Parenter Enteral Nutr 2019 Mar 19;43(3):335-346. Epub 2018 Nov 19.

Clinical Evaluation Research Unit, Kingston General Hospital, Kingston, Ontario, Canada and Department of Critical Care, Queen's University, Kingston, Ontario, Canada.

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http://doi.wiley.com/10.1002/jpen.1471
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http://dx.doi.org/10.1002/jpen.1471DOI Listing
March 2019

Evidence-Based Clinical Management of Ebola Virus Disease and Epidemic Viral Hemorrhagic Fevers.

Infect Dis Clin North Am 2019 Mar;33(1):247-264

Interdepartmental Division of Critical Care, University of Toronto, 209 Victoria Street, 4th Floor, Room 411, Toronto, Ontario M5B 1T8, Canada; Department of Medicine, Université de Sherbrooke, 300112e Avenue Nord, Sherbrooke, Québec J1H 5N4, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.idc.2018.10.013DOI Listing
March 2019

Effect of methylprednisolone on acute kidney injury in patients undergoing cardiac surgery with a cardiopulmonary bypass pump: a randomized controlled trial.

CMAJ 2019 Mar;191(9):E247-E256

Division of Nephrology (Garg, Cuerden, Sontrop), Department of Medicine, London Health Sciences Centre, London, Ont.; Department of Anaesthesia and Intensive Care (Chan), The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China; Departments of Health Research Methods, Evidence, and Impact, and Medicine (Devereaux, Walsh), McMaster University, Hamilton, Ont.; Tehran Heart Center (Abbasi), Tehran University of Medical Sciences, Tehran, Iran; Division of Nephrology (Hildebrand), Department of Medicine, University of Alberta, Edmonton, Alta.; Département de médecine (Lamontagne), Faculté de médecine et des sciences de la santé, Université de Sherbrooke, Sherbrooke, Que.; Department of Surgery (Lamy) McMaster University, Hamilton, Ont.; Department of Cardiac Surgery (Noiseux), Université de Montréal, Montréal, Que.; Division of Nephrology, Johns Hopkins School of Medicine (Parikh), Baltimore, Md.; The George Institute for Global Health (Perkovic), Sydney, Australia; Division of Cardiac Surgery (Quantz), London Health Sciences Centre, University Hospital, London, Ont.; Montreal Heart Institute (Rochon), Université de Montréal, Montréal, Que.; Department of Surgery (Royse), University of Melbourne, Melbourne, Australia; Department of Outcomes Research (Sessler), Cleveland Clinic, Cleveland, Ohio; Department of Cardiac Surgery (Shah), Princess Alexandra Hospital, Brisbane, Australia; Department of Cardiovascular and Thoracic Surgery (Tagarakis), Aristotle University of Thessaloniki, Thessaloniki, Greece; Division of Cardiac Surgery (Teoh), Southlake Regional Health Centre, Newmarket, Ont.; Population Health Research Institute (Vincent, Whitlock), Hamilton, Ont.; Department of Cardiothoracic Anesthesiology (Yared), Cleveland Clinic, Cleveland, Ohio; Division of Cardiology (Yusuf), Department of Medicine, McMaster University, Hamilton, Ont.

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http://www.cmaj.ca/lookup/doi/10.1503/cmaj.181644
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http://dx.doi.org/10.1503/cmaj.181644DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400656PMC
March 2019

LOW-VALUE CLINICAL PRACTICES IN INJURY CARE: A SCOPING REVIEW AND EXPERT CONSULTATION SURVEY.

J Trauma Acute Care Surg 2019 Mar 12. Epub 2019 Mar 12.

Population Health and Optimal Health Practices Research Unit, Trauma - Emergency - Critical Care Medicine, Centre de Recherche du CHU de Québec - Université Laval (Hôpital de l'Enfant-Jésus), Université Laval, Québec (Qc), Canada.

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http://dx.doi.org/10.1097/TA.0000000000002246DOI Listing
March 2019

The evolution of supportive care for Ebola virus disease.

Lancet 2019 02 4;393(10172):620-621. Epub 2019 Feb 4.

University of Toronto, Toronto, ON, Canada; Sunnybrook Health Science Center, Toronto, ON, Canada.

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http://dx.doi.org/10.1016/S0140-6736(19)30242-9DOI Listing
February 2019

Canadian Critical Care Society revised process for guideline development and endorsement.

Can J Anaesth 2018 Oct 30;65(10):1163-1164. Epub 2018 Jul 30.

Health Research Methods, Evaluation and Impact, McMaster University, Hamilton, ON, Canada.

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http://dx.doi.org/10.1007/s12630-018-1182-3DOI Listing
October 2018

Incidence and impact of withdrawal of life-sustaining therapies in clinical trials of severe traumatic brain injury: A systematic review.

Clin Trials 2018 08 4;15(4):398-412. Epub 2018 Jun 4.

1 Population Health and Optimal Health Practices Research Unit, Trauma-Emergency-Critical Care Medicine, Centre de recherche du CHU de Québec-Université Laval, Québec, QC, Canada.

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http://dx.doi.org/10.1177/1740774518771233DOI Listing
August 2018

Target blood pressure for septic and vasodilatory shock: what is optimal?

Intensive Care Med 2018 04 12;44(4):548-549. Epub 2018 Mar 12.

University Hospital of Angers, Angers, France.

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http://dx.doi.org/10.1007/s00134-018-5127-7DOI Listing
April 2018

7 versus 14 days of antibiotic treatment for critically ill patients with bloodstream infection: a pilot randomized clinical trial.

Trials 2018 Feb 17;19(1):111. Epub 2018 Feb 17.

Departments of Medicine and Critical Care Medicine, Sunnybrook Health Sciences Center, Adjunct Scientist, Institute for Clinical Evaluative Sciences, Sunnybrook Health Sciences Centre, Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1186/s13063-018-2474-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816399PMC
February 2018

Permissive hypotension during shock resuscitation: equipoise in all patients?

Intensive Care Med 2018 01 27;44(1):87-90. Epub 2017 May 27.

Department of Critical Care Medicine, Sunnybrook Health Sciences Centre and Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Canada.

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http://link.springer.com/10.1007/s00134-017-4849-2
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http://dx.doi.org/10.1007/s00134-017-4849-2DOI Listing
January 2018

Septic shock resuscitation in the first hour.

Curr Opin Crit Care 2017 Dec;23(6):561-566

aIntensive Care Unit, Barwon Health, University Hospital Geelong, Geelong, Victoria, Australia bCentre de Recherche du CHU de Sherbrooke cFaculté de Médecine et des Sciences de la Santé, University of Sherbrooke, Sherbrooke, Québec, Canada dSt Thomas' Hospital, Guy's and St Thomas' NHS Foundation Trust eSchool of Immunology & Microbial Sciences, Kings College London, London, UK.

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http://dx.doi.org/10.1097/MCC.0000000000000460DOI Listing
December 2017

A multi-center prospective cohort study of patient transfers from the intensive care unit to the hospital ward.

Intensive Care Med 2017 Oct 29;43(10):1485-1494. Epub 2017 Aug 29.

Department of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta and Alberta Health Services, Edmonton, Canada.

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http://dx.doi.org/10.1007/s00134-017-4910-1DOI Listing
October 2017

The intensive care medicine research agenda on septic shock.

Intensive Care Med 2017 Sep 12;43(9):1294-1305. Epub 2017 May 12.

Division of Medicine, Bloomsbury Institute of Intensive Care Medicine, University College London, London, United Kingdom.

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http://dx.doi.org/10.1007/s00134-017-4821-1DOI Listing
September 2017

Understanding patient-centredness: contrasting expert versus patient perspectives on vasopressor therapy for shock.

Intensive Care Med 2017 07 13;43(7):1052-1054. Epub 2016 Sep 13.

Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1007/s00134-016-4518-xDOI Listing
July 2017

An environmental scan of quality indicators in critical care.

CMAJ Open 2017 Jun;5(2):E488-E495

Affiliations: University of Ottawa (Valiani, Gheshmy), Ottawa, Ont.; Centre de Recherche du Centre hospitalier de l'Université de Montréal (Rigal), Montréal, Que.; Departments of Critical Care Medicine and Community Health Sciences (Stelfox), University of Calgary, Calgary, Alta.; Department of Medicine (Muscedere), Queen's University, Kingston, Ont.; Lawson Health Research Institute (Martin), London Health Sciences Centre, London, Ont.; Division of Critical Care Medicine and Centre for Health Evaluation & Outcome Sciences (Dodek), St. Paul's Hospital and University of British Columbia, Vancouver, BC; Centre de recherche clinique Étienne-Le Bel (Lamontagne), Université de Sherbrooke, Sherbrooke, Que.; Departments of Medicine and Critical Care Medicine (Fowler), Sunnybrook Hospital, Toronto, Ont.; Departments of Medicine and of Clinical Epidemiology and Biostatistics (Cook), McMaster University, Hamilton, Ont.; Department of Medicine (Forster), University of Ottawa; Clinical Epidemiology Program (Forster), Ottawa Hospital Research Institute, Ottawa, Ont.; Département de Médecine (Hébert), Centre hospitalier de l'Université de Montréal, Hôpital Notre-Dame, Montréal, Que.

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http://dx.doi.org/10.9778/cmajo.20150139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5498320PMC
June 2017

A path to precision in the ICU.

Crit Care 2017 04 3;21(1):79. Epub 2017 Apr 3.

Department of Critical Care Medicine, Queen's University, Kingston, ON, Canada.

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http://dx.doi.org/10.1186/s13054-017-1653-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376689PMC
April 2017

qSOFA for Identifying Sepsis Among Patients With Infection.

JAMA 2017 01;317(3):267-268

Intensive Care National Audit & Research Centre (ICNARC), London, United Kingdom.

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http://dx.doi.org/10.1001/jama.2016.19684DOI Listing
January 2017

Pathogens and antimicrobial susceptibility profiles in critically ill patients with bloodstream infections: a descriptive study.

CMAJ Open 2016 Oct-Dec;4(4):E569-E577. Epub 2016 Oct 13.

Dalla Lana School of Public Health (Savage), University of Toronto; Sunnybrook Health Sciences Centre (Savage, Fowler, Rishu, Daneman), Toronto, Ont.; Division of Critical Care Medicine (Fowler), Department of Medicine; Institute of Health Policy, Management and Evaluation (Fowler, Daneman), University of Toronto, Toronto, Ont.; Division of Critical Care Medicine (Bagshaw), Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alta.; Departments of Medicine and Clinical Epidemiology & Biostatistics (Cook), McMaster University, Hamilton, Ont.; Division of Critical Care Medicine (Dodek, Reynolds), Department of Medicine, University of British Columbia; Center for Health Evaluation and Outcome Sciences (Dodek), St. Paul's Hospital, Vancouver, BC; Department of Critical Care Medicine (Hall), Faculty of Medicine, Dalhousie University; Nova Scotia Health Authority (Hall), Halifax, NS; Section of Critical Care Medicine (Kumar), Department of Medicine; Departments of Medical Microbiology and of Pharmacology and Therapeutics (Kumar), University of Manitoba, Winnipeg, Man.; Centre de recherche du Centre hospitalier universitaire de Sherbrooke (Lamontagne), Sherbrooke, Que.; Service de médecine interne (Lamontagne), Département de médecine, Université de Sherbrooke, Sherbrooke, Que.; Axe Santé des populations et pratiques optimales en santé (Lauzier), Centre de recherche du Centre hospitalier universitaire de Québec-Université Laval, Québec, Que.; Départements de medicine et d'anesthésiologie et de soins intensifs (Lauzier), Université Laval, Québec, Que.; St. Michael's Hospital (Marshall), Toronto, Ont.; Department of Surgery (Marshall), University of Toronto, Toronto, Ont.; Department of Medicine (Martin), Western University; Critical Care Medicine (Martin), Schulich School of Medicine & Dentistry, London Health Sciences Centre, London, Ont.; Division of Critical Care (McIntyre), Department of Medicine, The Ottawa Hospital, Ottawa, Ont.; Department of Medicine (Muscedere), Queen's University, Kingston, Ont.; Department of Critical Care Medicine (Muscedere), Kingston General Hospital, Kingston, Ont.; Department of Critical Care Medicine (Stelfox), University of Calgary, Calgary, Alta.; Division of Infectious Diseases (Daneman), Department of Medicine, University of Toronto; Institute for Clinical Evaluative Sciences (Daneman), Toronto, Ont.

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http://dx.doi.org/10.9778/cmajo.20160074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5173462PMC
October 2016

When to start renal replacement therapy in critically ill patients with acute kidney injury: comment on AKIKI and ELAIN.

Crit Care 2016 08 6;20(1):245. Epub 2016 Aug 6.

Division of Nephrology, St. Michaels Hospital, University of Toronto, 30 Bond St, Toronto, Ontario, M5B 1W8, Canada.

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http://dx.doi.org/10.1186/s13054-016-1424-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975880PMC
August 2016

Early mobilization of critically ill adults: a survey of knowledge, perceptions and practices of Canadian physicians and physiotherapists.

CMAJ Open 2016 Jul-Sep;4(3):E448-E454. Epub 2016 Aug 18.

Department of Medicine (Koo), Western University, London, Ont.; Department of Pediatrics (Choong); Department of Medicine (Choong, Cook, Guyatt, Meade); Department of Clinical Epidemiology and Biostatistics (Choong, Cook, Guyatt, Meade), McMaster University, Hamilton, Ont.; Department of Medicine (Herridge, Burns), University of Toronto; Hamilton General Hospital (Newman, Meade), Hamilton, Ont.; University Health Network (Lo), Toronto General Hospital, Toronto, Ont.; Centre de recherche du Centre hospitalier universitaire de Sherbrooke and Université de Sherbrooke (Lamontagne), Sherbrooke, Que.; Swedish Medical Group (Koo, Priestap, Campbell), Seattle, Wash.

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http://dx.doi.org/10.9778/cmajo.20160021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047804PMC
August 2016

Predictive value of neuron-specific enolase for prognosis in patients with moderate or severe traumatic brain injury: a systematic review and meta-analysis.

CMAJ Open 2016 Jul-Sep;4(3):E371-E382. Epub 2016 Jul 22.

Centre de recherche du CHU de Québec - Université Laval (Mercier, Boutin, Shemilt, Lauzier, Moore, Archambault, Légaré, Turgeon), Population Health and Optimal Health Practices Research Unit; Department of Social and Preventive Medicine (Boutin, Moore); Department of Anesthesiology and Critical Care Medicine (Lauzier, Archambault, Turgeon), Division of Critical Care Medicine; Department of Family Medicine and Emergency Medicine (Archambault, Légaré), Faculty of Medicine (Lauzier); Department of Molecular Biology (Rousseau, Nadeau), Medical Biochemistry and Pathology, Université Laval, Québec City, Que.; Department of Haematology and Medical Oncology (Zarychanski), University of Manitoba, Winnipeg, Man.; Center for Transfusion and Critical Care Research (Fergusson, McIntyre, Turgeon), Clinical Epidemiology Unit, Ottawa Health Research Institute, University of Ottawa; Department of Critical Care Medicine (Fergusson, McIntyre), Ottawa Hospital, University of Ottawa, Ottawa, Ont.; Centre de Recherche Étienne Lebel (Lamontagne), Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Que.; Department of Medicine (Lamontagne), Université de Sherbrooke, Sherbrooke, Que.

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http://dx.doi.org/10.9778/cmajo.20150061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5143026PMC
July 2016

β-Blockers in sepsis: protocol for a systematic review and meta-analysis of randomised control trials.

BMJ Open 2016 06 23;6(6):e012466. Epub 2016 Jun 23.

Department of Medicine, McMaster University, Hamilton, Ontario, Canada Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1136/bmjopen-2016-012466DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932247PMC
June 2016

One-Year Outcomes in Caregivers of Critically Ill Patients.

N Engl J Med 2016 May;374(19):1831-41

From the Department of Occupational Science and Occupational Therapy (J.I.C., L.C.), Rehabilitation Sciences Institute (J.I.C., S.Mathur, P.R.), Toronto Rehabilitation Institute, University Health Network (J.I.C., J.F., M.B.), Department of Medicine, Toronto General Research Institute, Institute of Medical Science, University Health Network (L.M.C., A.M., G.T., C.T., N.D.F., J.F., M.B., V.L., M.P., D.M., L.F., E.F., M.E.W., P.R., S.B., M.C., L.S., C.C., C.-W.C., S.K., M.S.H.), Interdepartmental Division of Critical Care (J.O.F., S. Mehta, N.D.F., N.K.J.A., J.B., C.S., M.P., C.M.L., R.F., D.C.S., T.S., B.H.C., C.C., C.-W.C., L.B., A.S.S., M.S.H.), Departments of Medicine and Critical Care (J.O.F., J.B., C.S., L.R., L.B., J.C.M.) and Keenan Research Center at the Li Ka Shing Knowledge Institute (L.B., A.S.S., J.C.M.), St. Michael's Hospital, Department of Medicine and Anesthesia, Mount Sinai Hospital (S. Mehta, C.M.L., L.R., L.S.), Department of Critical Care Medicine, Sunnybrook Health Sciences Centre (N.K.J.A., R.F., D.C.S., T.S., B.H.C., L.R.), Interdepartmental Division of Physiatry (J.F., M.B.), Department of Psychiatry, University Health Network (S.E.A., A.T.), and Department of Physical Therapy (S. Mathur), University of Toronto, Toronto, the Departments of General Internal Medicine and Critical Care, St. Joseph's Healthcare (J.C.R.), and the Departments of Pediatrics (K.C.) and Medicine (D.C.), Division of Critical Care and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (F.L., P.H.) and the School of Rehabilitation and Research Centre on Aging, Health and Social Services Centre (M.L.), University of Sherbrooke, Sherbrooke, QC, the Department of Critical Care, University of Ottawa, Ottawa (H.M.), the Department of Medicine Division of Critical Care, Maisonneuve Rosemont Hospital, University of Montreal, Montreal (Y.S.), and the Department of Medicine, St. Paul's H

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http://dx.doi.org/10.1056/NEJMoa1511160DOI Listing
May 2016

Duration of Antimicrobial Treatment for Bacteremia in Canadian Critically Ill Patients.

Crit Care Med 2016 Feb;44(2):256-64

1Division of Infectious Diseases, Department of Medicine and Clinical Epidemiology, Sunnybrook Health Sciences Centre, University of Toronto and Adjunct Scientist, Institute for Clinical Evaluative Sciences, Sunnybrook Health Sciences Centre, Toronto, ON, Canada. 2Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, Toronto, ON, Canada. 3Division of Critical Care Medicine, University of Alberta, Edmonton, AB, Canada. 4Division of Critical Care Medicine and Center for Health Evaluation and Outcome Sciences, St. Paul's Hospital and University of British Columbia, Vancouver, BC, Canada. 5Department of Critical Care Medicine, Dalhousie University and the Capital District, Health Authority, Halifax, NS, Canada. 6Sections of Critical Care Medicine and Infectious Diseases, University of Manitoba, Winnipeg, MB, Canada. 7Department of Medicine, Centre de recherche du CHU de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada. 8Centre de recherche du CHU de Québec, Axe santé des populations et pratiques optimales en santé, Division de soins intensifs adultes, départements de médecine et d'anesthésiologie, Université Laval, Quebec, QC, Canada. 9Departments of Surgery and Critical Care Medicine, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada. 10Department of Medicine, University of Western Ontario, London, ON, Canada. 11Division of Critical Care, Department of Medicine, The Ottawa Hospital, Ottawa, ON, Canada. 12Department of Medicine, Queen's University, Kingston, ON, Canada. 13Department of Medicine, University of British Columbia, Vancouver, BC, Canada. 14Department of Critical Care Medicine, University of Calgary, Calgary, AB, Canada. 15Departments of Medicine, Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada. 16Department of Medicine and Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1097/CCM.0000000000001393DOI Listing
February 2016

Premature Discontinuation of Randomized Trials in Critical and Emergency Care: A Retrospective Cohort Study.

Crit Care Med 2016 Jan;44(1):130-7

1Department of Clinical Research, Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Basel, Switzerland.2Department of Medicine, Academy of Swiss Insurance Medicine, University Hospital Basel, Basel, Switzerland.3Cochrane Switzerland, Institute of Social and Preventive Medicine (IUMSP), Lausanne University Hospital, Lausanne, Switzerland.4Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada.5Department of Medicine, McMaster University, Hamilton, Ontario, Canada.6German Cochrane Centre, Medical Center-University of Freiburg, Freiburg, Germany.7Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland.8Centre de Recherche Clinique du Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, Canada.9Department of Health and Society, Austrian Federal Institute for Health Care, Vienna, Austria.10Departments of Urology and Public Health, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.11Department of Internal Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile.12Evidence-Based Dentistry Unit, Faculty of Dentistry, Universidad de Chile, Santiago, Chile.13Michael G. DeGroote Institute for Infectious Diseases Research, McMaster University, Hamilton, Ontario, Canada.14Department of Internal Medicine, American University of Beirut, Beirut, Lebanon.15Department of Medicine, State University of New York at Buffalo, Buffalo, NY.16Chinese Evidence-Based Medicine Center, West China Hospital, Sichuan University, Chengdu, China.17Department of Neonatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.18Department of Anesthesia, McMaster University, Hamilton, Ontario, Canada.19Michael G. DeGroote Institute for Pain Research and Care, McMaster University, Hamilton, Ontario, Canada.20Epidemiology Unit, Department of Cardiology, Vall d'Hebron Hospital and CIBER de Epidem

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http://repositorio.uchile.cl/bitstream/handle/2250/136563/Pr
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http://dx.doi.org/10.1097/CCM.0000000000001369DOI Listing
January 2016

Competing Risk Analysis for Evaluation of Dalteparin Versus Unfractionated Heparin for Venous Thromboembolism in Medical-Surgical Critically Ill Patients.

Medicine (Baltimore) 2015 Sep;94(36):e1479

From the Department of Clinical Epidemiology and Biostatistics (GL, DC, MAHL, GG, MC, DHA, AH, SDW, LT); Department of Medicine (DC, MAHL, GG, AH); St. Joseph's Healthcare Hamilton, McMaster University, Hamilton, ON (DC, MAHL, MC, AH, LT); Centre de recherche du CHU de Sherbrooke et Université de Sherbrooke, Sherbrooke, QC (FL); Interdepartmental Division of Critical Care Medicine, Departments of Medicine and Physiology, and Institute for Health Policy, Management and Evaluation, University of Toronto (NDF); Department of Medicine, Division of Respirology, University Health Network and Mount Sinai Hospital (NDF); Toronto General Research Institute, Toronto, ON, Canada (NDF); Critical Care and Trauma Division, The George Institute, Sydney, Australia (SF); King Saud bin Abdulaziz University for Health Sciences and King Abdullah International Medical Research Center, Riyadh, Saudi Arabia (YMA); Australian and New Zealand Intensive Care Research Centre (RB, DC); School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia (DC).

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http://dx.doi.org/10.1097/MD.0000000000001479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4616653PMC
September 2015

Completion and Publication Rates of Randomized Controlled Trials in Surgery: An Empirical Study.

Ann Surg 2015 Jul;262(1):68-73

*Department of Surgery, University Hospital Basel, Spitalstrasse, Basel, Switzerland †Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital of Basel, Hebelstrasse, Basel, Switzerland ‡Department of Oncology, Basel University Hospital, Basel, Switzerland §Cochrane Switzerland, Institute of Social and Preventive Medicine (IUMSP), Lausanne University Hospital, Lausanne, Switzerland ¶Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada ‖Department of Medicine, McMaster University, Hamilton, Ontario, Canada **German Cochrane Centre, Department of Medical Biometry and Medical Informatics, University Medical Center Freiburg, Freiburg, Germany ††Institute of Social and Preventive Medicine, University of Zurich, Zurich, Switzerland ‡‡Department of Public Health, University of Helsinki, Helsinki, Finland §§Department of Urology, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland ¶¶Department of Internal Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile ‖‖Evidence-Based Dentistry Unit, Faculty of Dentistry, Universidad de Chile, Santiago, Chile ***Department of Family Medicine, McMaster University, Hamilton, Ontario, Canada †††Michael G. DeGroote Institute for Infectious Diseases Research, McMaster University, Hamilton, Ontario, Canada ‡‡‡Department of Internal Medicine, American University of Beirut, Riad-El-Solh, Beirut, Lebanon §§§Department of Medicine, State University of New York at Buffalo, Buffalo, NY ¶¶¶Center for Pediatric Clinical Studies, Department of Neonatology, University Children's Hospital, Tuebingen, Germany and Division of Neonatology, University Hospital Zurich, Zurich, Switzerland ‖‖‖Department of Anesthesia, McMaster University, Hamilton, Ontario, Canada ****Michael G. DeGroote Institute for Pain Research and Care, McMaster University, Hamilton, Ontario, Canada ††††Epidemiolo

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July 2015

Blood pressure targets for vasopressor therapy: a systematic review.

Shock 2015 Jun;43(6):530-9

*Department of Anaesthesia, Division of Critical Care, McMaster University; and †Departments of Medicine, and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario; ‡Centre Hospitalier Universitaire de Québec Research Center, Population Health and Optimal Health Practices, Division of Critical Care Medicine, Department of Anesthesiology, Department of Medicine, Université Laval, Québec, Québec; and §Department of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada; ∥Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Basel, Switzerland; ¶Department of Anesthesiology, University of Ottawa, and **Department of Pharmacy, The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada; ††Département de Réanimation Médicale et de Médecine Hyperbare, Centre Hospitalier Universitaire Angers, Angers, France; ‡‡Centre Hospitalier Universitaire de Québec Research Center, Population Health and Optimal Health Practices, Division of Critical Care Medicine, Department of Anesthesiology, Université Laval, Québec, Québec; §§Department of Medicine, Thrombosis and Atherosclerosis Research Institute, McMaster University, Hamilton; and ∥∥Li Ka Shing Knowledge Institute, St. Michaels Hospital, University of Toronto, Toronto, Ontario; and ¶¶Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Département de médicine, Faculté de médecine et des sciences de la santé, Université de Sherbrooke, Sherbrooke, Québec, Canada.

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June 2015

Nonbeneficial treatment Canada: definitions, causes, and potential solutions from the perspective of healthcare practitioners*.

Crit Care Med 2015 Feb;43(2):270-81

1Divisions of Critical Care and Palliative Care, Department of Medicine, University of Toronto, Toronto, ON, Canada. 2Departments of Medicine and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada. 3Division of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AL. 4Division of Critical Care, Department of Medicine, University of Toronto, Toronto, ON, Canada. 5Centre de Recherche Étienne-Le Bel, Université de Sherbrooke, Sherbrooke, QC, Canada. 6Interdepartmental Division of Critical Care, University of Toronto, and Keenan Research Centre and the Li KaShing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada. 7Department of Emergency Medicine and Critical Care, Lakeridge Health, Oshawa, ON, Canada. 8Departments of Surgery and Critical Care Medicine, Faculty of Medicine and Dentistry, University of Ottawa, Ottawa, ON, Canada. 9Department of Medicine, McMaster University, Hamilton, ON, Canada. 10Division of Critical Care, Department of Anesthesiology, Université Laval, Québec, QC, Canada 11Research Center of the Centre Hospitalier Universitaire (CHU) de Québec, Axe Santé des populations-Pratiques Optimales en Santé, Traumatologie-Urgence-Soins Intensifs, CHU de Québec (Hôpital de l'Enfant-Jésus), Université Laval, Québec City, QC, Canada. 12Division of Critical Care Medicine and Center for Health Evaluation and Outcome Sciences, St. Paul's Hospital and University of British Columbia, Vancouver, BC, Canada. 13Trauma, Emergency Medicine and Critical Care, Sunnybrook Hospital, Toronto, ON, Canada. 14Interdepartmental Division of Critical Care, Department of Medicine, University of Toronto, Toronto, ON, Canada.

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February 2015

Failure of anticoagulant thromboprophylaxis: risk factors in medical-surgical critically ill patients*.

Crit Care Med 2015 Feb;43(2):401-10

1Department of Medicine, McMaster University, Hamilton, ON, Canada. 2Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada. 3Research Center of the CHU de Québec, Population Health and Optimal Health Practices Research Unit, Québec, QC, Canada. 4Division of Critical Care, Department of Medicine, Québec, QC, Canada. 5Section of Critical Care, Department of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada. 6Section of Hematology/Medical Oncology, Department of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada. 7Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada. 8Division of Critical Care, Department of Medicine, Centre de Recherche Clinique Étiene-Le Bel, Université de Sherbrooke, Sherbrooke, QC, Canada. 9Division of Critical Care Medicine and Center for Health Evaluation and Outcome Sciences, St. Paul's Hospital and University of British Columbia, Vancouver, BC, Canada. 10Department of Critical Care, University of Ottawa, Ottawa, ON, Canada. 11Department of Anesthesia, Queen Elizabeth II Health Sciences Centre, 12Department of Critical Care, Queen Elizabeth II Health Sciences Centre, Halifax, NS, Canada. 13Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada. 14Department of Medicine, Queen's University, Kingston, ON, Canada. 15Department of Anesthesiology, Québec, QC, Canada. 16Department of Medicine, University of Toronto, Toronto, ON, Canada. 17Malcolm Fisher Department of Intensive Care Medicine, Royal North Shore Hospital, Sydney, Australia. 18The George Institute for Global Health, University of Sydney, Sydney, Australia. 19Department of Critical Care, University of Alberta, Edmonton, AB, Canada. 20Department of Anesthesia, University of Alberta, Edmonton, AB, Canada. 21Department of Medicine, Research Institute-HCor, Hospital do Coracao, Sao Paolo, Brazil. 22Department of Intensive Care Medicine, Guys

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February 2015

What really matters in end-of-life discussions? Perspectives of patients in hospital with serious illness and their families.

CMAJ 2014 Dec 3;186(18):E679-87. Epub 2014 Nov 3.

Departments of Medicine, Clinical Epidemiology and Biostatistics (You), McMaster University, Hamilton, Ont.; Division of Critical Care Medicine (Dodek), St. Paul's Hospital; Center for Health Evaluation and Outcome Sciences (Dodek), University of British Columbia, Vancouver, BC; Centre de Recherche Clinique Hôpital Universitaire de Sherbrooke (Lamontagne), Université de Sherbrooke, Sherbrooke, Qué.; Divisions of Critical Care and Palliative Care (Downar), Department of Medicine, University of Toronto; Department of Critical Care Medicine and Sunnybrook Research Institute (Sinuff), Sunnybrook Health Sciences Centre; Interdepartmental Division of Critical Care Medicine (Sinuff), University of Toronto, Toronto, Ont.; Clinical Evaluation Research Unit, Department of Medicine (Jiang, Day, Heyland), Kingston General Hospital, Kingston, Ont.; Department of Community Health and Epidemiology (Heyland), Queen's University, Kingston, Ont.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259796PMC
December 2014

Doing today's work superbly well--treating Ebola with current tools.

N Engl J Med 2014 Oct 24;371(17):1565-6. Epub 2014 Sep 24.

From the Centre de Recherche Clinique, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada (F.L.); Réanimation Médicale, Polyclinique Bordeaux Nord Aquitaine, Bordeaux, France (C.C.); Liverpool School of Tropical Medicine, Liverpool, United Kingdom (T.F.); University of Washington, Seattle (S.T.J.); University of North Carolina at Chapel Hill, Chapel Hill (W.A.F.); and University of Toronto, Toronto (R.A.F.).

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October 2014

Clinical outcomes, predictors, and prevalence of anterior pituitary disorders following traumatic brain injury: a systematic review.

Crit Care Med 2014 Mar;42(3):712-21

1Centre de Recherche du CHU de Québec, Santé des Populations et Pratiques Optimales en Santé, Université Laval, Québec, QC, Canada. 2Division of Critical Care, Department of Anesthesiology, Université Laval, Québec, QC, Canada. 3Department of Medicine, Université Laval, Québec, QC, Canada. 4Department of Family Medicine and Emergency Medicine, Université Laval, Québec, QC, Canada. 5Centre de recherche du CSSS Alphonse-Desjardins (CHAU de Lévis), Lévis, QC, Canada. 6Centre de Recherche Clinique Étienne-Le Bel, Université de Sherbrooke, Sherbrooke, QC, Canada. 7Department of Social and Preventive Medicine, Université Laval, Québec, QC, Canada. 8Hôpital du Sacré-Coeur de Montréal Research Center, Department of Medicine, Université de Montréal, Montréal, QC, Canada. 9Hôpital du Sacré-Coeur de Montréal Research Center, Department of Critical Care Medicine, Université de Montréal, Montréal, QC, Canada. 10 Centre de Recherche du CHU de Québec, Endocrinology and Nephrology, Université Laval, Québec, QC, Canada. 11Department of Medicine, McMaster University, Hamilton, ON, Canada. 12 Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada.

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March 2014

Prescribed targets for titration of vasopressors in septic shock: a retrospective cohort study.

CMAJ Open 2013 Oct 22;1(4):E127-33. Epub 2013 Oct 22.

Centre hospitalier universitaire de Sherbrooke, Sherbrooke, Que. ; Centre de recherche Étienne-Le Bel, Université de Sherbrooke, Sherbrooke, Que.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985969PMC
October 2013

Clinical trial design in acute lung injury--issues and controversies.

Semin Respir Crit Care Med 2013 Aug 11;34(4):516-21. Epub 2013 Aug 11.

Department of Clinical Epidemiology and Biostatistics, Faculty of Health Sciences, Health Sciences Centre, 1280 Main Street West, Hamilton, Ontario, Canada.

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August 2013

Publication bias in animal research: a systematic review protocol.

Syst Rev 2013 Apr 27;2:23. Epub 2013 Apr 27.

Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Basel, Switzerland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651300PMC
April 2013