Publications by authors named "Francesco Salvatore"

100Publications

The abundance of the long intergenic non-coding RNA 01087 differentiates between luminal and triple-negative breast cancers and predicts patient outcome.

Pharmacol Res 2020 11 14;161:105249. Epub 2020 Oct 14.

CEINGE-Biotecnologie Avanzate s.c.ar.l, Naples 80145, Italy; Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, Naples 80131, Italy; Inter-University Center for multifactorial and multi genetic chronic human diseases, "Federico II"- Naples, Tor Vergata- Roma II, and Chieti-Pescara Universities, Italy. Electronic address:

View Article and Find Full Text PDF
November 2020

The shift of the paradigm between ageing and diseases.

Clin Chem Lab Med 2020 Sep;58(10):1635-1644

Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, Naples, Italy.

View Article and Find Full Text PDF
September 2020

CHM/REP1 Transcript Expression and Loss of Visual Function in Patients Affected by Choroideremia.

Invest Ophthalmol Vis Sci 2019 04;60(5):1547-1555

Eye Clinic, Multidisciplinary Department of Medical, Surgical and Dental Sciences, University of Campania Luigi Vanvitelli, Naples, Italy.

View Article and Find Full Text PDF
April 2019

A multi-gene panel beyond BRCA1/BRCA2 to identify new breast cancer-predisposing mutations by a picodroplet PCR followed by a next-generation sequencing strategy: a pilot study.

Anal Chim Acta 2019 Jan 18;1046:154-162. Epub 2018 Sep 18.

CEINGE-Biotecnologie Avanzate, via Gaetano Salvatore 486, 80145, Naples, Italy; Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, via Sergio Pansini 5, 80131, Naples, Italy. Electronic address:

View Article and Find Full Text PDF
January 2019

Stability of cannabinoids in cannabis FM1 flowering tops and oil preparation evaluated by ultra-high performance liquid chromatography tandem mass spectrometry.

Clin Chem Lab Med 2019 06;57(7):e165-e168

National Centre on Addiction and Doping, Istituto Superiore di Sanità, V.le Regina Elena 299, 00161 Rome, Italy, Phone: +390649906545, Fax: +390649902016.

View Article and Find Full Text PDF
June 2019

Iron (II) Citrate Complex as a Food Supplement: Synthesis, Characterization and Complex Stability.

Nutrients 2018 Nov 3;10(11). Epub 2018 Nov 3.

Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, via Pansini, 5, 80131 Naples, Italy.

View Article and Find Full Text PDF
November 2018

Unraveling unusual X-chromosome patterns during fragile-X syndrome genetic testing.

Clin Chim Acta 2018 Jan 21;476:167-172. Epub 2017 Nov 21.

Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università di Napoli Federico II, Naples, Italy; CEINGE-Biotecnologie Avanzate, Naples, Italy. Electronic address:

View Article and Find Full Text PDF
January 2018

A rare case of sterol-C4-methyl oxidase deficiency in a young Italian male: Biochemical and molecular characterization.

Mol Genet Metab 2017 08 27;121(4):329-335. Epub 2017 Jun 27.

Dipartimento di Medicina Clinica e Sperimentale, Università degli Studi di Foggia, Viale L. Pinto 1, 71122 Foggia, Italy. Electronic address:

View Article and Find Full Text PDF
August 2017

Unveiling the in Vivo Protein Corona of Circulating Leukocyte-like Carriers.

ACS Nano 2017 03 10;11(3):3262-3273. Epub 2017 Mar 10.

Department of Orthopedics and Sports Medicine, Houston Methodist Hospital , 6565 Fannin Street, Houston, Texas 77030, United States.

View Article and Find Full Text PDF
March 2017

Host defense peptide-derived privileged scaffolds for anti-infective drug discovery.

J Pept Sci 2017 Apr 12;23(4):303-310. Epub 2017 Jan 12.

CEINGE-Biotecnologie Avanzate, Via Gaetano Salvatore 486, 80145, Naples, Italy.

View Article and Find Full Text PDF
April 2017

Biomarker discovery by proteomics-based approaches for early detection and personalized medicine in colorectal cancer.

Proteomics Clin Appl 2017 05 17;11(5-6). Epub 2017 Jan 17.

CEINGE, Advanced Biotechnology s.c.a.r.l., Via G. Salvatore 486, Naples, Italy.

View Article and Find Full Text PDF
May 2017

A novel fully human anti-NCL immunoRNase for triple-negative breast cancer therapy.

Oncotarget 2016 Dec;7(52):87016-87030

Department of Molecular Medicine and Medical Biotechnology, University of Naples "Federico II", 80131 Naples, Italy.

View Article and Find Full Text PDF
December 2016

"Classical organic acidurias": diagnosis and pathogenesis.

Clin Exp Med 2017 Aug 9;17(3):305-323. Epub 2016 Sep 9.

Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli "Federico II", Naples, Italy.

View Article and Find Full Text PDF
August 2017

Epigenetic features of FoxP3 in children with cow's milk allergy.

Clin Epigenetics 2016 12;8:86. Epub 2016 Aug 12.

Department of Translational Medical Science, University of Naples "Federico II", Via S. Pansini, 5 80131 Naples, Italy ; CEINGE-Biotecnologie Avanzate s.c.ar.l, Via Gaetano Salvatore 486, 80131 Naples, Italy ; European Laboratory for the Investigation of Food-Induced Diseases, University of Naples "Federico II", Via S. Pansini 5, 80131 Naples, Italy.

View Article and Find Full Text PDF
April 2017

RBM5-AS1 Is Critical for Self-Renewal of Colon Cancer Stem-like Cells.

Cancer Res 2016 10 12;76(19):5615-5627. Epub 2016 Aug 12.

Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York. Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York. Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York.

View Article and Find Full Text PDF
October 2016

Effects of the protein corona on liposome-liposome and liposome-cell interactions.

Int J Nanomedicine 2016 4;11:3049-63. Epub 2016 Jul 4.

Center for Biomimetic Medicine, Houston Methodist Research Institute, Houston, TX, USA; Department of Orthopedics, Houston Methodist Hospital, Houston, TX, USA.

View Article and Find Full Text PDF
March 2017

One-pot synthesis of pH-responsive hybrid nanogel particles for the intracellular delivery of small interfering RNA.

Biomaterials 2016 May 27;87:57-68. Epub 2016 Jan 27.

Department of Regenerative Medicine: Center for Biomimetic Medicine, Houston Methodist Research Institute, Houston, Texas, 77030 United States.

View Article and Find Full Text PDF
May 2016

Clinical and genetic characterization of patients with hypertrophic cardiomyopathy and right atrial enlargement.

J Cardiovasc Med (Hagerstown) 2017 Apr;18(4):249-254

aU.O.C. di Cardiologia, Seconda Università degli Studi di Napoli, A.O. Monadi, Azienda dei Colli bCEINGE-Biotecnologie Avanzate s.c.ar.l. cDipartimento di Biochimica e Biotecnologie Mediche, Università degli Studi di Napoli 'Federico II', Naples dUnità di 'Imaging Cardiovascolare', Ospedale Santa Maria delle Grazie, Pozzuoli eCardiology Division, Heart Department, 'Cava de' Tirreni and Amalfi Coast' Hospital, University of Salerno, Salerno fCardiac Surgery Department, IRCCS Policlinico San Donato, Milan, Italy gInherited Heart Disease Unit, The Heart Hospital, London, UK.

View Article and Find Full Text PDF
April 2017

Cracking the Code of Human Diseases Using Next-Generation Sequencing: Applications, Challenges, and Perspectives.

Biomed Res Int 2015 19;2015:161648. Epub 2015 Nov 19.

CEINGE-Biotecnologie Avanzate, Via G Salvatore 486, 80145 Naples, Italy ; Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, Ed. 19, Via Sergio Pansini 5, 80131 Naples, Italy.

View Article and Find Full Text PDF
September 2016

The impact of nanoparticle protein corona on cytotoxicity, immunotoxicity and target drug delivery.

Nanomedicine (Lond) 2016 Jan 11;11(1):81-100. Epub 2015 Dec 11.

Department of Regenerative Medicine, Houston Methodist Research Institute, 6670 Bertner Avenue, 77030 Houston, TX, USA.

View Article and Find Full Text PDF
January 2016

Late diagnosis of Fabry disease caused by a de novo mutation in a patient with end stage renal disease.

BMC Res Notes 2015 Nov 24;8:711. Epub 2015 Nov 24.

Chair of Nephrology, Department of Public Health, University Federico II of Naples, Naples, Italy.

View Article and Find Full Text PDF
November 2015

Design and activity of a cyclic mini-β-defensin analog: a novel antimicrobial tool.

Int J Nanomedicine 2015 15;10:6523-39. Epub 2015 Oct 15.

Dipartimento di Farmacia, Università di Napoli Federico II, Naples, Italy ; Istituto di Biostrutture e Bioimmagini, CNR, Naples, Italy.

View Article and Find Full Text PDF
August 2016

Towards the identification of the allosteric Phe-binding site in phenylalanine hydroxylase.

J Biomol Struct Dyn 2016 19;34(3):497-507. Epub 2015 Oct 19.

a CEINGE-Biotecnologie Avanzate , S.c. a r.l., Napoli , Italy.

View Article and Find Full Text PDF
December 2016

Red blood cells affect the margination of microparticles in synthetic microcapillaries and intravital microcirculation as a function of their size and shape.

J Control Release 2015 Nov 15;217:263-72. Epub 2015 Sep 15.

Dipartimento di Ingegneria Chimica, dei Materiali e della Produzione Industriale, Università di Napoli Federico II, Italy; CEINGE Biotecnologie avanzate, Napoli, Italy.

View Article and Find Full Text PDF
November 2015

Novel mitochondrial protein interactors of immunoglobulin light chains causing heart amyloidosis.

FASEB J 2015 Nov 28;29(11):4614-28. Epub 2015 Jul 28.

*Amyloidosis Research and Treatment Center, Department of Molecular Medicine, **Department of Internal Medicine, Department of Cardiothoracic and Vascular Sciences, Laboratory of Experimental Cardiology for Cell and Molecular Therapy, University of Pavia, and Clinical Chemistry Laboratory, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia, Italy; Centro di Ricerca di Ingegneria Genetica (CEINGE)-Biotecnologie Avanzate, Naples, Italy; Department of Movement Sciences, Parthenope University of Naples, Naples, Italy; Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, Naples, Italy; Department of Biology, University of Padua, Padua, Italy; and Department of Medicine, University of Cape Town, Cape Town, South Africa

View Article and Find Full Text PDF
November 2015

The multi-faceted aspects of the complex cardiac Nav1.5 protein in membrane function and pathophysiology.

Biochim Biophys Acta 2015 Oct 21;1854(10 Pt A):1502-9. Epub 2015 Jul 21.

CEINGE-Biotecnologie Avanzate s.c.ar.l., Naples, Italy; IRCCS-Fondazione SDN, Naples, Italy. Electronic address:

View Article and Find Full Text PDF
October 2015

Human anti-nucleolin recombinant immunoagent for cancer therapy.

Proc Natl Acad Sci U S A 2015 Jul 13;112(30):9418-23. Epub 2015 Jul 13.

Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, OH 43210;

View Article and Find Full Text PDF
July 2015

Enabling cytoplasmic delivery and organelle targeting by surface modification of nanocarriers.

Nanomedicine (Lond) 2015 Jul;10(12):1923-40

Department of Nanomedicine, Houston Methodist Research Institute, 6670 Bertner Ave., Houston, TX 77030, USA.

View Article and Find Full Text PDF
July 2015

The molecular analysis of BRCA1 and BRCA2: Next-generation sequencing supersedes conventional approaches.

Clin Chim Acta 2015 Jun 17;446:221-5. Epub 2015 Apr 17.

CEINGE-Biotecnologie Avanzate, via G. Salvatore 486, 80145 Naples, Italy; Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, Via Pansini 5, 80131 Naples, Italy; IRCCS-Fondazione SDN, Naples, Italy. Electronic address:

View Article and Find Full Text PDF
June 2015

Differences in DNA methylation profile of Th1 and Th2 cytokine genes are associated with tolerance acquisition in children with IgE-mediated cow's milk allergy.

Clin Epigenetics 2015 31;7:38. Epub 2015 Mar 31.

Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico I, Via S.Pansini, 5 80131 Naples, Italy ; CEINGE-Biotecnologie Avanzate s.c.ar.l, University of Naples 'Federico II', Via S.Pansini, 5 80131 Naples, Italy.

View Article and Find Full Text PDF
April 2015

Biological role of mannose binding lectin: From newborns to centenarians.

Clin Chim Acta 2015 Dec 14;451(Pt A):78-81. Epub 2015 Mar 14.

CEINGE-Biotecnologie Avanzate scarl, Naples, Italy; Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università di Napoli Federico II, Naples, Italy. Electronic address:

View Article and Find Full Text PDF
December 2015

Membrane protein 4F2/CD98 is a cell surface receptor involved in the internalization and trafficking of human β-Defensin 3 in epithelial cells.

Chem Biol 2015 Feb 29;22(2):217-28. Epub 2015 Jan 29.

CEINGE-Biotecnologie Avanzate S.c.a r.l., Via Gaetano Salvatore 486, 80145 Naples, Italy; IRCCS-Fondazione SDN, Via Emanuele Gianturco 113, 80142 Naples, Italy. Electronic address:

View Article and Find Full Text PDF
February 2015

The role of the gut microbiome in the healthy adult status.

Clin Chim Acta 2015 Dec 10;451(Pt A):97-102. Epub 2015 Jan 10.

CEINGE-Biotecnologie Avanzate, via G. Salvatore 486, 80145 Naples, Italy; Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, via Pansini 5, 80131 Naples, Italy; IRCCS-Fondazione SDN, 80143 Naples, Italy. Electronic address:

View Article and Find Full Text PDF
December 2015

Quality of Life (QoL) assessment in a cohort of patients with phenylketonuria.

BMC Public Health 2014 Dec 4;14:1243. Epub 2014 Dec 4.

Division of Inborn Metabolic Diseases, Department of Pediatrics, Padua University Hospital, Padua, Italy.

View Article and Find Full Text PDF
December 2014

Proteomic Profiling of a Biomimetic Drug Delivery Platform.

Curr Drug Targets 2015 ;16(13):1540-7

Department of Nanomedicine, The Houston Methodist Research Institute, Houston, 6670 Bertner Avenue, Houston Texas 77030, USA.

View Article and Find Full Text PDF
August 2016

Multistage Nanovectors Enhance the Delivery of Free and Encapsulated Drugs.

Curr Drug Targets 2015 ;16(14):1582-90

Houston Methodist Research Institute, 6670 Bertner Avenue MS R7-414, Houston, TX 77030-2602, USA.

View Article and Find Full Text PDF
September 2016

Pearls & oy-sters: familial epileptic encephalopathy due to methylenetetrahydrofolate reductase deficiency.

Neurology 2014 Jul;83(3):e41-4

From the Department of Translational Medicine, Section of Pediatrics (G.C., G.P., E.D.G.), the Department of Molecular Medicine and Medical Biotechnologies (G.F., R.R.), and the Diagnostic Imaging Department, Unit of Neuroradiology (A.D., B.C.), University of Naples Federico II; CEINGE-Biotecnologie Avanzate s.c.ar.l. (C.C., G.F., R.R., F.S.), Naples; and IRCCS-Fondazione SDN (F.S.), Naples, Italy.

View Article and Find Full Text PDF
July 2014

Comparative metagenomic analysis of human gut microbiome composition using two different bioinformatic pipelines.

Biomed Res Int 2014 25;2014:325340. Epub 2014 Feb 25.

CEINGE-Biotecnologie Avanzate, Via G. Salvatore, 80145 Naples, Italy ; Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, Via S. Pansini, 80131 Naples, Italy ; IRCCS-Fondazione SDN, Via Gianturco, 80143 Naples, Italy.

View Article and Find Full Text PDF
December 2014

Child neurology: Recurrent rhabdomyolysis due to a fatty acid oxidation disorder.

Neurology 2014 Jan;82(1):e1-4

From the Departments of Pediatrics (G.T., N.B.-P., G.P., A.R., G.A.) and Molecular Medicine and Medical Biotechnologies (M.R., G.F.), University of Naples Federico II; CEINGE-Biotecnologie Avanzate s.c.ar.l. (M.R., C.C., E.S., F.S., G.F.); and IRCCS-Fondazione SDN (F.S.), Naples, Italy.

View Article and Find Full Text PDF
January 2014

Genetic analysis in a family affected by sick sinus syndrome may reduce the sudden death risk in a young aspiring competitive athlete.

Int J Cardiol 2014 Jan 12;170(3):e63-5. Epub 2013 Nov 12.

CEINGE-Biotecnologie Avanzate s.c.ar.l., Naples, Italy; IRCCS-Fondazione SDN, Naples, Italy. Electronic address:

View Article and Find Full Text PDF
January 2014

Identification of a deletion in the NDUFS4 gene using array-comparative genomic hybridization in a patient with suspected mitochondrial respiratory disease.

Gene 2014 Feb 1;535(2):376-9. Epub 2013 Dec 1.

Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università di Napoli Federico II, Naples, Italy; CEINGE-Biotecnologie Avanzate, Naples, Italy.

View Article and Find Full Text PDF
February 2014

Structural features of the regulatory ACT domain of phenylalanine hydroxylase.

PLoS One 2013 14;8(11):e79482. Epub 2013 Nov 14.

CEINGE-Biotecnologie Avanzate, S.c.a r.l., Napoli, Italy ; Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli studi di Napoli "Federico II", Napoli, Italy ; Randall Division of Cell and Molecular Biophysics, King's College London, London, United Kingdom.

View Article and Find Full Text PDF
November 2014

Serum from humans on long-term calorie restriction enhances stress resistance in cell culture.

Aging (Albany NY) 2013 Aug;5(8):599-606

Division of Geriatrics and Nutritional Science, Washington University School of Medicine, St. Louis, MO 63130, USA.

View Article and Find Full Text PDF
August 2013