Publications by authors named "Farida Benhadou"

22 Publications

  • Page 1 of 1

Metabolic syndrome and hidradenitis suppurativa: epidemiological, molecular, and therapeutic aspects.

Int J Dermatol 2021 Sep 16. Epub 2021 Sep 16.

Department of Dermatology, Liverpool Hospital, University of New South Wales, Sydney, NSW, Australia.

Hidradenitis suppurativa (HS) is a chronic, suppurative condition of the pilosebaceous unit. Patients suffering from HS demonstrate a molecular profile in keeping with a state of systemic inflammation and are often found to fit the criteria for a diagnosis of metabolic syndrome (MetS). In this paper, we review the literature with regards to established data on the prevalence of MetS in HS patients and revise the odds ratio of comorbid disease. Furthermore, we attempt to draw parallels between inflammatory pathways in HS and MetS and evaluate how convergences may explain the risk of comorbid disease, necessitating the need for multidisciplinary care.
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http://dx.doi.org/10.1111/ijd.15910DOI Listing
September 2021

Unilateral Nevoid Telangiectasia in a Healthy Man.

Case Rep Dermatol 2021 May-Aug;13(2):330-335. Epub 2021 Jun 23.

Department of Dermatology, Hôpital Erasme, Université libre de Bruxelles, Brussels, Belgium.

We report the case of a healthy 26-year-old man presenting telangiectatic macules on the left thorax and arm since childhood. The main diagnostic hypothesis were unilateral nevoid telangiectasia (UNT), hereditary benign telangiectasia, atrial myxoma, segmental serpiginous angioma, circumscribed neviform angiokeratoma, and nevus vascularis mixtus. The diagnosis retained was UNT characterized by congenital or acquired telangiectasia distributed asymmetrically along the upper extremities, or the third or fourth cervical dermatomes. The congenital form is extremely rare, predominant in men, and persists in adulthood. The acquired form is most frequent, affects preferentially women, usually appears at puberty or during pregnancy and tends to disappear. Estrogen excess triggers the formation of telangiectasia. UNT is rarely associated with liver or thyroid disorder. Pulsed-dye lasers and normalization of estrogen are proposed as therapeutic options. We report a rare diagnosis of UNT in a young man with no other underlying condition. We would like to highlight that in the presence of unilateral telangiectasia, a complete clinical examination must be performed to rule out signs of hyperestrogenism in man, ocular or neurological abnormalities, a blood test to exclude pregnancy, hepatic and thyroid dysfunctions, and ultrasonography in case of suspicion of atrial myxoma.
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http://dx.doi.org/10.1159/000514941DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8299370PMC
June 2021

Tuberculosis Risk Stratification of Psoriatic Patients Before Anti-TNF-α Treatment.

Front Immunol 2021 3;12:672894. Epub 2021 Jun 3.

Laboratory of Vaccinology and Mucosal Immunity, Université Libre de Bruxelles (U.L.B.), Brussels, Belgium.

Psoriasis is a skin inflammatory condition for which significant progress has been made in its management by the use of targeted biological drugs. Detection of latent infection (LTBI) is mandatory before starting biotherapy that is associated with reactivation risk. Together with evaluation of TB risk factors and chest radiographs, tuberculin skin tests (TST) and/or blood interferon-γ-release assays (IGRA), like the QuantiFERON (QFT), are usually performed to diagnose infection. Using this approach, 14/49 psoriatic patients prospectively included in this study were identified as LTBI (14 TST, induration size ≥ 10mm, 8 QFT), and 7/14 received prophylactic anti-TB treatment, the other 7 reporting past-treatment. As the specificity and sensitivity of these tests were challenged, we evaluated the added value of an IGRA in response to a mycobacterial antigen associated with latency, the heparin-binding haemagglutinin (HBHA). All but one TST patient had a positive HBHA-IGRA, indicating higher sensitivity than the QFT. The HBHA-IGRA was also positive for 12/35 TSTQFT patients. Measurement for 15 psoriatic patients (12 with HBHA-IGRA) of 8 chemokines in addition to IFN-γ revealed a broad array of HBHA-induced chemokines for TSTQFT and TSTQFT patients, compared to a more restricted pattern for TSTQFT patients. This allowed us to define subgroups within psoriatic patients characterized by different immune responses to antigens that may be associated to different risk levels of reactivation of the infection. This approach may help in prioritizing patients who should receive prophylactic anti-TB treatment before starting biotherapies in order to reduce their number.
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http://dx.doi.org/10.3389/fimmu.2021.672894DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8209474PMC
June 2021

Factors Determining Affected Sites in Hidradenitis Suppurativa.

Dermatology 2021 Feb 1:1-3. Epub 2021 Feb 1.

ResoVerneuil, Paris, France,

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http://dx.doi.org/10.1159/000513866DOI Listing
February 2021

Do collagen-related diseases represent a risk factor for hidradenitis suppurativa?

Exp Dermatol 2021 Jun 5;30(6):872-873. Epub 2021 Feb 5.

ResoVerneuil, Paris, France.

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http://dx.doi.org/10.1111/exd.14290DOI Listing
June 2021

The efficacy and tolerability of tetracyclines and clindamycin plus rifampicin for the treatment of hidradenitis suppurativa: Results of a prospective European cohort study.

J Am Acad Dermatol 2021 08 20;85(2):369-378. Epub 2021 Jan 20.

Erasmus MC, University Medical Center Rotterdam, Department of Dermatology, Rotterdam, the Netherlands. Electronic address:

Background: Tetracyclines and clindamycin plus rifampicin combination therapy are both considered first-line therapy in current hidradenitis suppurativa guidelines. However, evidence for their efficacy is drawn from small studies, often without validated outcomes.

Objective: To assess the 12-week efficacy of oral tetracyclines and a combination of clindamycin and rifampicin.

Methods: A prospective, international cohort study performed between October 2018 and August 2019.

Results: In total, 63.6% of the included 283 patients received oral tetracyclines, and 36.4% were treated with clindamycin and rifampicin. Both groups showed a significant decrease in International Hidradenitis Suppurativa Severity Score System from baseline (both P < .001). The Hidradenitis Suppurativa Clinical Response (HiSCR) was achieved in 40.1% and 48.2% of patients, respectively (P = .26). Patient characteristics or disease severity were not associated with the attainment of HiSCR or the minimal clinically important differences for the Dermatology Life Quality Index and pain.

Limitations: Cohort study. Respectively, 23.9% and 19.4% of patients had to be excluded from the HiSCR analysis for the tetracycline and combination therapy group because of a low abscess and nodule count at baseline.

Conclusion: This study shows significant efficacy of both tetracycline treatment and clindamycin and rifampicin combination therapy after 12 weeks in patients with hidradenitis suppurativa. No significant differences in efficacy were observed between the 2 treatments, regardless of disease severity.
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http://dx.doi.org/10.1016/j.jaad.2020.12.089DOI Listing
August 2021

What causes hidradenitis suppurativa ?-15 years after.

Exp Dermatol 2020 12;29(12):1154-1170

European Hidradenitis Suppurativa Foundation e.V., Dessau, Germany.

The 14 authors of the first review article on hidradenitis suppurativa (HS) pathogenesis published 2008 in EXPERIMENTAL DERMATOLOGY cumulating from the 1st International Hidradenitis Suppurativa Research Symposium held March 30-April 2, 2006 in Dessau, Germany with 33 participants were prophetic when they wrote "Hopefully, this heralds a welcome new tradition: to get to the molecular heart of HS pathogenesis, which can only be achieved by a renaissance of solid basic HS research, as the key to developing more effective HS therapy." (Kurzen et al. What causes hidradenitis suppurativa? Exp Dermatol 2008;17:455). Fifteen years later, there is no doubt that the desired renaissance of solid basic HS research is progressing with rapid steps and that HS has developed deep roots among inflammatory diseases in Dermatology and beyond, recognized as "the only inflammatory skin disease than can be healed". This anniversary article of 43 research-performing authors from all around the globe in the official journal of the European Hidradenitis Suppurativa Foundation e.V. (EHSF e.V.) and the Hidradenitis Suppurativa Foundation, Inc (HSF USA) summarizes the evidence of the intense HS clinical and experimental research during the last 15 years in all aspects of the disease and provides information of the developments to come in the near future.
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http://dx.doi.org/10.1111/exd.14214DOI Listing
December 2020

Proposed Definitions of Typical Lesions in Hidradenitis Suppurativa.

Dermatology 2020 9;236(5):431-438. Epub 2020 Jun 9.

Private practice, Paris, France.

Background: Although not rare, hidradenitis suppurativa (HS) is often under-recognized by physicians. The diagnosis of HS is clinical via the recognition of lesions typical of the disease, but universally accepted definitions of these latter are currently lacking, which means that certain severity scores employed for HS classification/management are used differently by different physicians. Our aim was to develop a set of descriptive definitions and associated images of HS lesions, in order to enable doctors to better recognize and evaluate the disease.

Methods: MEDLINE-available literature and dermatological textbooks on HS morphology were retrieved (January 1996 to February 2016). A preliminary set of definitions of HS typical lesions was created, including 10 terms. Each term was associated with a pathophysiological classification and an image. This preliminary set was shown during the 5th Conference of the European HS Foundation (EHSF). The physicians attending the event were invited to vote on each term and make comments via a voting sheet.

Results: A total of 81 physicians answered the questionnaire. Their agreement/disagreement rates and comments were used to obtain a revised set of definitions and images. Pathophysiological classifications were dropped.

Conclusion: A user-friendly set of definitions/images of HS typical lesions was proposed and will need to be validated by further studies. This set could ultimately serve as a tool to better recognize, score, and assess treatment efficacy.
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http://dx.doi.org/10.1159/000507348DOI Listing
July 2021

Clinical characteristics of pediatric hidradenitis suppurativa: a cross-sectional multicenter study of 140 patients.

Arch Dermatol Res 2020 Dec 12;312(10):715-724. Epub 2020 Mar 12.

Department of Pediatric Dermatology, University Children's Hospital Zurich, Zurich, Switzerland.

Hidradenitis suppurativa (HS) rarely affects pediatric patients. The literature on pediatric HS patients is scarce. This is a cross-sectional study based on case note review or interviews and clinical examination of 140 pediatric patients undergoing secondary or tertiary level care. Patients were predominantly female (75.5%, n = 105) with a median age of 16. 39% reported 1st-degree relative with HS. Median BMI percentile was 88, and 11% were smokers (n = 15). Median modified Sartorius score was 8.5. Notable comorbidities found were acne (32.8%, n = 45), hirsutism (19.3%, n = 27), and pilonidal cysts (16.4%, n = 23). Resorcinol (n = 27) and clindamycin (n = 25) were the most frequently used topical treatments. Patients were treated with tetracycline (n = 32), or oral clindamycin and rifampicin in combination (n = 29). Surgical excision was performed in 18 patients, deroofing in five and incision in seven patients. Obesity seemed to be prominent in the pediatric population and correlated to parent BMI, suggesting a potential for preventive measures for the family. Disease management appeared to be similar to that of adult HS, bearing in mind that the younger the patient, the milder the disease in majority of cases.
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http://dx.doi.org/10.1007/s00403-020-02053-6DOI Listing
December 2020

Low Prevalence of GSC Gene Mutations in a Large Cohort of Predominantly Caucasian Patients with Hidradenitis Suppurativa.

J Invest Dermatol 2020 10 3;140(10):2085-2088.e14. Epub 2020 Mar 3.

Laboratory of Genetic Skin Diseases, INSERM UMR1163 Imagine Institute, Paris, France; Paris University, Paris, France; European Hidradenitis Suppurativa Foundation e.V., Dessau, Germany; Department of Genetics, Necker-Enfants Malades Hospital, AP-HP, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2019.10.025DOI Listing
October 2020

Hidradenitis Suppurativa and Bipolar Disorders: A Role for Lithium Therapy?

Dermatology 2020;236(4):305-306. Epub 2020 Feb 7.

ResoVerneuil, Paris, France,

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http://dx.doi.org/10.1159/000505912DOI Listing
May 2021

Epidermal autonomous VEGFA/Flt1/Nrp1 functions mediate psoriasis-like disease.

Sci Adv 2020 01 8;6(2):eaax5849. Epub 2020 Jan 8.

Laboratory of Stem Cells and Cancer, Université Libre de Bruxelles, Brussels, Belgium.

Psoriasis is a common chronic skin disorder characterized by keratinocyte hyperproliferation with altered differentiation accompanied by inflammation and increased angiogenesis. It remains unclear whether the first events that initiate psoriasis development occur in keratinocytes or inflammatory cells. Here, using different psoriasis mouse models, we showed that conditional deletion of or in epidermal cells inhibited psoriasis mediated by overexpression or deletion. Administration of anti-Nrp1 antibody reverted the psoriasis phenotype. Using transcriptional and chromatin profiling of epidermal cells following overexpression together with or deletion, we identified the gene regulatory network regulated by // during psoriasis development and uncovered a key role of Fosl1 in regulating the chromatin remodeling mediated by overexpression in keratinocytes. In conclusion, our study identifies an epidermal autonomous function of Vegfa/Nrp1/Flt1 that mediates psoriatic-like disease and demonstrates the clinical relevance of blocking Vegfa/Nrp1/Flt1 axis in psoriasis.
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http://dx.doi.org/10.1126/sciadv.aax5849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949033PMC
January 2020

Which Factors Determine Affected Sites in Hidradenitis Suppurativa?

Dermatology 2020 6;236(1):15-20. Epub 2020 Jan 6.

ResoVerneuil, Paris, France,

Background: The factors that determine whether an area of the body will be affected by hidradenitis suppurativa (HS) are unknown.

Methods: To address these factors, we performed multivariate regression analyses in a cohort of 1,138 patients.

Results: We found that the body sites affected occurred in specific combinations that were influenced by sex and body mass index. We also revealed unexpected correlations between some sites and other comorbidities such as inflammatory diseases, acne conglobata, or dissecting folliculitis of the scalp.

Conclusion: Such correlations are crucial to unravel a disease as variable as HS and identify pathophysiological mechanisms to enable the provision of personalized management.
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http://dx.doi.org/10.1159/000505292DOI Listing
September 2020

Chilblains.

Vasa 2020 Mar 6;49(2):133-140. Epub 2019 Dec 6.

Department of Vascular Diseases, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium.

Idiopathic chilblain is a relatively common yet poorly recognized acrosyndrome. This literature review aims to better understand and draw attention to this disorder. Chilblain is a localized inflammation of the skin that occurs on exposure to cold but non-freezing wet weather. It usually resolves spontaneously. The etiology is uncertain, but vasospasm seems to play a role in this abnormal reaction to cold. Diagnosis is most often based on clinical presentation, but a skin biopsy can be useful in dubious cases. In histology, dermal edema and an inflammatory infiltrate are usually present. A distribution of the infiltrate particularly around the eccrine gland is typical. Systemic symptoms and underlying autoimmune disease should be screened. Avoiding cold and keeping extremities warm is the first recommendation for management, as well as smoking cessation. Calcium channel blockers (in particular nifedipine) seems to be the treatment that has been most evaluated in chilblains. However, their effectiveness is not confirmed by all studies. Topical betamethasone is often used but its effect has not been confirmed by randomized clinical trials. Other treatments, such as pentoxifylline, hydrochloroquine and topical nitroglycerin have shown positive effects only in a reduced number of patients. Acupuncture seems to bring a benefit.
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http://dx.doi.org/10.1024/0301-1526/a000838DOI Listing
March 2020

Psoriasis: Keratinocytes or Immune Cells - Which Is the Trigger?

Dermatology 2019 19;235(2):91-100. Epub 2018 Dec 19.

Dermatology Department, Erasme Hospital, Université Libre de Bruxelles - ULB, Brussels, Belgium.

Background: Psoriasis is a common, chronic inflammatory skin disorder, which can significantly impact quality of life. Despite major breakthroughs in our understanding of the pathogenesis of psoriasis, the chronological order of the underlying mechanisms leading to the development of psoriatic plaques remains to be completely understood.

Summary: Although psoriasis is classically perceived as a T-cell disease, it is now well recognized that T lymphocytes do not function in exclusivity. This theory is supported by evidence from transgenic murine models that develop marked psoriasiform disease. In addition, immune cells and cytokines regulate both early and late events involved in the pathogenesis of psoriasis. Key Messages: Psoriasis is a complex disease - a dynamic interplay between immune cells, keratinocytes, and various other skin-resident cells, such as endothelial and immune cells. The contribution of each cell type is crucial in the initiation and maintenance phases of psoriatic alterations.
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http://dx.doi.org/10.1159/000495291DOI Listing
June 2019

Occurrence of an invasive cervical epidermoid carcinoma in a patient receiving TNF-α blocking therapy for hidradenitis suppurativa.

JAAD Case Rep 2018 Oct 3;4(9):857-859. Epub 2018 Oct 3.

Department of Dermatology, Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium.

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http://dx.doi.org/10.1016/j.jdcr.2018.06.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172443PMC
October 2018

Low Back Pain in Hidradenitis Suppurativa: A Diagnosis Not to Miss!

Case Rep Dermatol 2018 May-Aug;10(2):187-189. Epub 2018 Jul 12.

Dermatology Department, Erasme Hospital, Université Libre de Bruxelles, ULB, Brussels, Belgium.

We report the case of a patient suffering from hidradenitis suppurativa since puberty and complaining of chronic low back pain associated to altered sensitivity and muscular weakness in the right leg. A diagnosis of lumbosciatica was confirmed. Symptoms were not relieved after the use of nonsteroidal anti-inflammatory drugs and analgesics. A surgical decompression was then indicated but heavily debated. Indeed, extended inflammatory and fibrotic hidradenitis suppurativa lesions were located regarding the skin area eligible for the proposed surgery. A combined therapy with clindamycine/rifampicin was started and the surgery was postponed. A complete remission of the articular symptoms was observed 1 month after the start of the antibiotherapy and the inflammatory skin lesions were greatly improved. With the presentation of this clinical case, we would like to discuss the spectrum of rheumatic disorders associated to hidradenitis suppurativa that needs to be correctly diagnosed and taken into consideration in the therapeutic management of the patient.
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http://dx.doi.org/10.1159/000490880DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6103332PMC
July 2018

Psoriasis and Microbiota: A Systematic Review.

Diseases 2018 Jun 2;6(2). Epub 2018 Jun 2.

Dermatology Department, Erasmus Medical Center, 3000 Rotterdam, The Netherlands.

Background: Recent advances have highlighted the crucial role of microbiota in the pathophysiology of chronic inflammatory diseases as well as its impact on the efficacy of therapeutic agents. Psoriasis is a chronic, multifactorial inflammatory skin disorder, which has a microbiota distinct from healthy, unaffected skin.

Aim: Through an extensive review of the literature, we aim to discuss the skin and gut microbiota and redefine their role in the pathogenesis of psoriasis.

Conclusions: Unfortunately, the direct link between the skin microbiota and the pathogenesis of psoriasis remains to be clearly established. Apart from improving the course of psoriasis, selective modulation of the microbiota may increase the efficacy of medical treatments as well as attenuate their side effects.
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http://dx.doi.org/10.3390/diseases6020047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023392PMC
June 2018

Acute Erythroderma in a Patient Receiving TNF-α-Blocking Therapy for Hidradenitis Suppurativa.

Case Rep Dermatol 2018 Jan-Apr;10(1):7-12. Epub 2018 Jan 31.

Dermatology, Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium.

Tumor necrosis factor-α (TNF-α) normally binds to TNF-α receptors, leading to the inflammatory response of autoimmune diseases. Adalimumab is a TNF-inhibiting, anti-inflammatory, biological medication which binds to TNF-α, thus reducing this inflammatory response. The use of TNF-α-inhibiting medication, such as adalimumab, being the first FDA-approved treatment for hidradenitis suppurativa, has drastically changed the management of dermatological diseases. One rarely reported manifestation that occurs as a side effect associated with the use of TNF-α-blocking agents is erythroderma. This study, for the first time, reports the case of a patient suffering from hidradenitis suppurativa with concomitant psoriasis, who developed a severe and acute erythrodermic rash after the start of adalimumab therapy.
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http://dx.doi.org/10.1159/000485911DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836174PMC
January 2018

Inflammatory bowel disease is associated with hidradenitis suppurativa: Results from a multicenter cross-sectional study.

J Am Acad Dermatol 2017 Jan 25;76(1):49-53. Epub 2016 Oct 25.

Department of Dermatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. Electronic address:

Background: Hidradenitis suppurativa (HS) is often associated with inflammatory bowel disease (IBD; Crohn's disease or ulcerative colitis). However, the prevalence of IBD in HS patients is unknown.

Objective: To determine the prevalence of IBD in HS patients, and determine if patients with HS and IBD have a distinct HS phenotype.

Methods: For this multicenter, cross-sectional study, HS patients were asked during their first consultation if they had IBD. The diagnosis of IBD was checked in the medical files, and clinical characteristics were collected.

Results: IBD had a prevalence of 3.3% (95% CI 2.3-4.4) in 1076 HS patients. The prevalence of Crohn's disease was 2.5% (95% CI 1.6-3.4) and the prevalence of ulcerative colitis was 0.8% (95% CI 0.3-1.4). HS-IBD patients were less frequently obese (13.9% vs 31.2%, P = .04) than HS-only patients, but there were no differences in gender, family history of HS, disease severity, body areas affected by HS, or smoking status.

Limitations: The prevalence might be underestimated since HS patients might still develop IBD.

Conclusion: The prevalence of IBD in HS patients (3.3%) is 4-8 times higher than the prevalence in the general northern European population (0.41%-0.74%), however HS-IBD patients do not have a distinct HS phenotype.
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http://dx.doi.org/10.1016/j.jaad.2016.08.031DOI Listing
January 2017

Transgenic mouse technology in skin biology: generation of knockin mice.

J Invest Dermatol 2014 Dec;134(12):1-3

Department of Dermatology and Venereology, Medical University of Innsbruck, Innsbruck, Austria.

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http://dx.doi.org/10.1038/jid.2014.434DOI Listing
December 2014
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