Ernest Nadal

Ernest Nadal

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Ernest Nadal

Ernest Nadal

Publications by authors named "Ernest Nadal"

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Exploiting metabolic vulnerabilities of Non small cell lung carcinoma.

Semin Cell Dev Biol 2020 Feb 2;98:54-62. Epub 2019 Jul 2.

Cell Death Regulation Group, Oncobell Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.semcdb.2019.06.004DOI Listing
February 2020

Impact of baseline steroids on efficacy of programmed cell death-1 (PD-1) and programmed death-ligand 1 (PD-L1) blockade in patients with advanced non-small cell lung cancer.

Transl Lung Cancer Res 2019 Dec;8(Suppl 4):S364-S368

Department of Medical Oncology, Catalan Institute of Oncology, L'Hospitalet (Barcelona), Spain.

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http://dx.doi.org/10.21037/tlcr.2019.06.06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6987359PMC
December 2019

Mutations in the Antioxidant KEAP1/NRF2 Pathway Define an Aggressive Subset of NSCLC Resistant to Conventional Treatments.

J Thorac Oncol 2019 Nov;14(11):1881-1883

Cell Death Regulation Group, Oncobell Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet, Barcelona, Spain.

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http://dx.doi.org/10.1016/j.jtho.2019.08.005DOI Listing
November 2019

Comment on an external validation of the 8th edition of the TNM classification for lung cancer staging in patients treated with chemoradiation.

Ann Transl Med 2019 Jul;7(Suppl 3):S101

Department of Medical Oncology, Catalan Institute of Oncology, L'Hospitalet, Barcelona, Spain.

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http://dx.doi.org/10.21037/atm.2019.04.81DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685844PMC
July 2019

Thyroid dysfunction induced by nivolumab: searching for disease patterns and outcomes.

Endocrine 2019 06 25;64(3):605-613. Epub 2019 Feb 25.

Department of Endocrinology, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain.

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http://link.springer.com/10.1007/s12020-019-01871-7
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http://dx.doi.org/10.1007/s12020-019-01871-7DOI Listing
June 2019

Multidisciplinary expert opinion on the treatment consensus for patients with EGFR mutated NSCLC with brain metastases.

Crit Rev Oncol Hematol 2019 Jun 3;138:190-206. Epub 2019 Apr 3.

Clinical Research in Solid Tumors (CReST) and Neuro-Oncology Group. Oncobell, IDIBELL, Avda Gran Via 199-203, 08907, L'Hospitalet de Llobregat, Barcelona, Spain; Thoracic Oncology Unit, Department of Medical Oncology, Catalan Institute of Oncology. Avda Gran Via 199-203, 08907, L'Hospitalet de Llobregat, Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.critrevonc.2019.03.017DOI Listing
June 2019

Immunotherapy with checkpoint inhibitors in non-small cell lung cancer: insights from long-term survivors.

Cancer Immunol Immunother 2019 Mar 6;68(3):341-352. Epub 2019 Feb 6.

Lung Cancer Unit, Hospital Universitari Vall d'Hebron and Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.

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http://link.springer.com/10.1007/s00262-019-02310-2
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http://dx.doi.org/10.1007/s00262-019-02310-2DOI Listing
March 2019

Preoperative nutritional status assessment predicts postoperative outcomes in patients with surgically resected non-small cell lung cancer.

Eur J Surg Oncol 2018 09 11;44(9):1419-1424. Epub 2018 Apr 11.

Department of Thoracic Surgery, Hospital Universitari de Bellvitge, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.

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http://dx.doi.org/10.1016/j.ejso.2018.03.026DOI Listing
September 2018

-Oncogenic and -Inactivating Alterations Are Independent Factors That Affect Regulation of PD-L1 Expression in Lung Cancer.

Clin Cancer Res 2018 09 13;24(18):4579-4587. Epub 2018 Jun 13.

Genes and Cancer Group, Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Hospitalet de Llobregat, Barcelona, Spain.

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http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
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http://dx.doi.org/10.1158/1078-0432.CCR-18-0267DOI Listing
September 2018

SHP2 is required for growth of KRAS-mutant non-small-cell lung cancer in vivo.

Nat Med 2018 07 28;24(7):961-967. Epub 2018 May 28.

Division of Molecular Carcinogenesis, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/s41591-018-0023-9DOI Listing
July 2018

Genetic and cellular sensitivity of to the chemotherapeutic agent cisplatin.

Dis Model Mech 2018 06 21;11(6). Epub 2018 Jun 21.

Modeling human diseases in C. elegans. Genes, Diseases and Therapies Program, Bellvitge Biomedical Research Institute - IDIBELL, L'Hospitalet de Llobregat, 08908 Barcelona, Spain

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http://dx.doi.org/10.1242/dmm.033506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031354PMC
June 2018

Successful treatment with brigatinib in a patient with ALK-rearranged lung adenocarcinoma who developed crizotinib-induced interstitial lung disease.

Lung Cancer 2018 05 17;119:99-102. Epub 2018 Mar 17.

Department of Medical Oncology. Catalan Institute of Oncology. Avda Gran via 199-203. L'Hospitalet, Barcelona, Spain; Clinical Research in Solid Tumors Group (CReST), OncoBell Program.Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet, Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.lungcan.2018.03.014DOI Listing
May 2018

Geriatric assessment may help decision-making in elderly patients with inoperable, locally advanced non-small-cell lung cancer.

Br J Cancer 2018 03 30;118(5):639-647. Epub 2018 Jan 30.

Thoracic Oncology Unit, Department of Medical Oncology, Institut Català d'Oncologia, Hospital Duran i Reynals, Avinguda Gran via 199-203. L'Hospitalet, Barcelona 08908, Spain.

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http://dx.doi.org/10.1038/bjc.2017.455DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846066PMC
March 2018

KRAS oncogene in non-small cell lung cancer: clinical perspectives on the treatment of an old target.

Mol Cancer 2018 02 19;17(1):33. Epub 2018 Feb 19.

Department of Oncology, Clínica Universidad de Navarra, 31008, Pamplona, Spain.

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http://dx.doi.org/10.1186/s12943-018-0789-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817724PMC
February 2018

KRAS-driven lung adenocarcinoma: combined DDR1/Notch inhibition as an effective therapy.

ESMO Open 2016 6;1(5):e000076. Epub 2016 Sep 6.

Experimental Oncology, Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO) , Madrid , Spain.

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http://dx.doi.org/10.1136/esmoopen-2016-000076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5070278PMC
September 2016

A Novel Epigenetic Signature for Early Diagnosis in Lung Cancer.

Clin Cancer Res 2016 07 3;22(13):3361-71. Epub 2016 Feb 3.

Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet, Catalonia, Spain.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-2346DOI Listing
July 2016

Elevated levels of the complement activation product C4d in bronchial fluids for the diagnosis of lung cancer.

PLoS One 2015 23;10(3):e0119878. Epub 2015 Mar 23.

Program in Solid Tumors and Biomarkers, Center for Applied Medical Research (CIMA), Pamplona, Spain; Department of Biochemistry and Genetics, School of Sciences, University of Navarra, Pamplona, Spain.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0119878PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4370816PMC
March 2016

The role of Dickkopf-3 overexpression in esophageal adenocarcinoma.

J Thorac Cardiovasc Surg 2015 Aug 8;150(2):377-385.e2. Epub 2015 May 8.

Section of Thoracic Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor, Mich. Electronic address:

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http://dx.doi.org/10.1016/j.jtcvs.2015.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515149PMC
August 2015

A Novel Serum 4-microRNA Signature for Lung Cancer Detection.

Sci Rep 2015 Jul 23;5:12464. Epub 2015 Jul 23.

Section of Thoracic Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor, Michigan.

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http://dx.doi.org/10.1038/srep12464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378885PMC
July 2015

Intrinsic cancer subtypes--next steps into personalized medicine.

Cell Oncol (Dordr) 2015 Feb 14;38(1):3-16. Epub 2015 Jan 14.

Department of Medical Oncology, Catalan Institute of Oncology (ICO), L'Hospitalet de Llobregat, Av. Gran Via 199-203, 08907, Barcelona, Spain.

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http://dx.doi.org/10.1007/s13402-014-0203-7DOI Listing
February 2015

KRAS-G12C mutation is associated with poor outcome in surgically resected lung adenocarcinoma.

J Thorac Oncol 2015 Feb;10(2):e9-10

Department of Medical Oncology, Catalan Institute of Oncology, Avda Gran Via 199-203, L'Hospitalet, Barcelona, Spain University of Michigan, Comprehensive Cancer Center, Ann Arbor, Michigan.

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http://dx.doi.org/10.1097/JTO.0000000000000438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344375PMC
February 2015

Transcriptome meta-analysis of lung cancer reveals recurrent aberrations in NRG1 and Hippo pathway genes.

Nat Commun 2014 Dec 22;5:5893. Epub 2014 Dec 22.

1] Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA [2] Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA [3] Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA [4] Howard Hughes Medical Institute, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.

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http://dx.doi.org/10.1038/ncomms6893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274748PMC
December 2014

Modeling lung cancer evolution and preclinical response by orthotopic mouse allografts.

Cancer Res 2014 Nov 12;74(21):5978-88. Epub 2014 Sep 12.

Translational Research Laboratory, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain. XenOPAT S.L., Business Bioincubator, Bellvitge Health Science Campus, Barcelona, Spain.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-1606DOI Listing
November 2014

KRAS-G12C mutation is associated with poor outcome in surgically resected lung adenocarcinoma.

J Thorac Oncol 2014 Oct;9(10):1513-22

*Thoracic Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor, Michigan; †Michigan Center for Translational Pathology, Department of Pathology, University of Michigan, Ann Arbor, Michigan; ‡Division of Hematology/Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan; §Department of Biostatistics, University of Michigan, Ann Arbor, Michigan; ‖Veterans Administration Medical Center, Ann Arbor, Michigan; ¶Translational Research Laboratory, Catalan Institute of Oncology, L'Hospitalet de Llobregat, Barcelona, Spain; and #Department of Medical Oncology, Thoracic Oncology Multidisciplinary Unit, Catalan Institute of Oncology, L'Hospitalet de Llobregat, Barcelona, Spain.

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http://dx.doi.org/10.1097/JTO.0000000000000305DOI Listing
October 2014

A MicroRNA cluster at 14q32 drives aggressive lung adenocarcinoma.

Clin Cancer Res 2014 Jun 15;20(12):3107-17. Epub 2014 May 15.

Authors' Affiliations: Section of Thoracic Surgery, Department of Surgery, University of Michigan Medical School; Division of Medical Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan; and Xinjiang Medical University, Xinjiang, China

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http://dx.doi.org/10.1158/1078-0432.CCR-13-3348DOI Listing
June 2014

Linkage of DNA methylation quantitative trait loci to human cancer risk.

Cell Rep 2014 Apr 3;7(2):331-338. Epub 2014 Apr 3.

Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, 08908 Barcelona, Catalonia, Spain; Department of Physiological Sciences II, School of Medicine, University of Barcelona, 08036 Barcelona, Catalonia, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), 08010 Barcelona, Catalonia, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.03.016DOI Listing
April 2014

Epigenetic regulation of vitamin D metabolism in human lung adenocarcinoma.

J Thorac Oncol 2014 Apr;9(4):473-82

*Division of Medical Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan; †Ann Arbor Veterans Administration Medical Center, Ann Arbor, Michigan; ‡Section of Thoracic Surgery, Department of Surgery, University of Michigan, Ann Arbor, Michigan; §Cancer Epigenetics and Biology Program, Bellvitge Biomedical Research Institute, Barcelona, Spain; ‖Department of Environmental Health Sciences, School of Public Health, Ann Arbor, Michigan; ¶Division of Pulmonary Medicine, Department of Medicine, University of Michigan, Ann Arbor, Michigan; #Department of Physiological Sciences II, School of Medicine, University of Barcelona, Barcelona, Spain; **Institució Catalana de Recerca i Estudis Avançats, Barcelona, Spain; and ††College of Pharmacy and Research Institute of Pharmaceutical Science and Technology, Ajou University, Suwon, Republic of Korea.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994461PMC
http://dx.doi.org/10.1097/JTO.0000000000000114DOI Listing
April 2014

Epigenetic inactivation of microRNA-34b/c predicts poor disease-free survival in early-stage lung adenocarcinoma.

Clin Cancer Res 2013 Dec 15;19(24):6842-52. Epub 2013 Oct 15.

Authors' Affiliations: Thoracic Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor, Michigan; and Translational Research Laboratory and Departments of Pathology, Thoracic Surgery, and Medical Oncology, Thoracic Oncology Multidisciplinary Unit, Catalan Institute of Oncology, L'Hospitalet de Llobregat, Barcelona, Spain.

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http://clincancerres.aacrjournals.org/content/19/24/6842.ful
Web Search
http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
Publisher Site
http://dx.doi.org/10.1158/1078-0432.CCR-13-0736DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161219PMC
December 2013

A prognostic DNA methylation signature for stage I non-small-cell lung cancer.

J Clin Oncol 2013 Nov 30;31(32):4140-7. Epub 2013 Sep 30.

Juan Sandoval, Jesus Mendez-Gonzalez, F. Javier Carmona, Sergi Sayols, Sebastian Moran, Holger Heyn, Miguel Vizoso, Antonio Gomez, Montse Sanchez-Cespedes, and Manel Esteller, Bellvitge Biomedical Research Institute; Josefina Mora, Hospital de la Santa Creu i Sant Pau; Manel Esteller, University of Barcelona and Institucio Catalana de Recerca i Estudis Avançats, Barcelona; Miquel Taron and Rafael Rosell, Catalan Institute of Oncology, Badalona, Catalonia; Marina Pollan, Instituto de Salud Carlos III, Madrid; Maria J. Pajares and Luis M. Montuenga, University of Navarra; Wenceslao Torre, Clínica University de Navarra, Pamplona, Spain; Ernest Nadal, Guoan Chen, and David G. Beer, University of Michigan Medical School, Ann Arbor, MI; Yassen Assenov and Fabian Müller, Max Planck Institute, Saarbrücken, Germany; Christoph Bock, Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria; Lucia A. Muscarella, Istituto Di Ricovero e Cura a Carattere Scientifico (IRCCS) Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy; Triantafillos Liloglou, Michael Davies, and John K. Field, The University of Liverpool Cancer Research Centre, Liverpool, United Kingdom; Elisabeth Brambilla, Centre Hospitalier Universitaire A Michallon, Grenoble, France; Luca Roz, IRCCS Foundation National Cancer Institute, Milan; Marco Lo Iacono and Giorgio V. Scagliotti, University of Torino, Orbassano (Torino), Italy.

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http://dx.doi.org/10.1200/JCO.2012.48.5516DOI Listing
November 2013

Complement factor H is elevated in bronchoalveolar lavage fluid and sputum from patients with lung cancer.

Cancer Epidemiol Biomarkers Prev 2010 Oct 27;19(10):2665-72. Epub 2010 Aug 27.

Division of Oncology, Center for Applied Medical Research, Universidad de Navarra, Pamplona, Spain.

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http://dx.doi.org/10.1158/1055-9965.EPI-10-0467DOI Listing
October 2010