Eric P Brass

Eric P Brass

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Eric P Brass

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Ensuring Sustainability of Needed Antibiotics: Aiming for the DART Board.

Ann Intern Med 2019 Oct 8. Epub 2019 Oct 8.

David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, California (E.P.B.).

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http://dx.doi.org/10.7326/M19-1893DOI Listing
October 2019

Sustainable Discovery and Development of Antibiotics - Is a Nonprofit Approach the Future?

N Engl J Med 2019 Aug 19;381(6):503-505. Epub 2019 Jun 19.

From the Stritch School of Medicine and the Parkinson School of Health Sciences and Public Health, Loyola University Chicago, Maywood, IL (T.B.N.); the David Geffen School of Medicine at the University of California, Los Angeles (E.P.B.) and the Los Angeles County and University of Southern California Medical Center (B.S.) - both in Los Angeles; the Providence Portland Medical Center and University of Oregon Health Sciences School of Medicine, Portland (D.N.G.); and the Johns Hopkins University School of Medicine, Baltimore (J.G.B.).

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http://dx.doi.org/10.1056/NEJMp1905589DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6697094PMC
August 2019

Poison center exposures due to therapeutic misuse of nonprescription acetaminophen-containing combination products in the United States 2007-2016.

Clin Toxicol (Phila) 2019 May 11;57(5):350-355. Epub 2018 Oct 11.

b Rocky Mountain Poison and Drug Center , Denver Health and Hospital Authority , Denver , CO , USA.

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https://www.tandfonline.com/doi/full/10.1080/15563650.2018.1
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http://dx.doi.org/10.1080/15563650.2018.1517879DOI Listing
May 2019

The Effectiveness of Nonprescription Drug Labels in the United States: Insights from Recent Research and Opportunities for the Future.

Pharmacy (Basel) 2018 Oct 26;6(4). Epub 2018 Oct 26.

Department of Medicine, University of California, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.3390/pharmacy6040119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306891PMC
October 2018

Medication Errors With Pediatric Liquid Acetaminophen After Standardization of Concentration and Packaging Improvements.

Acad Pediatr 2018 07 6;18(5):563-568. Epub 2018 Mar 6.

Rocky Mountain Poison and Drug Center, Denver Health and Hospital Authority, Denver, Colo.

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http://dx.doi.org/10.1016/j.acap.2018.03.001DOI Listing
July 2018

Frequency of Poison Center Exposures for Pediatric Accidental Unsupervised Ingestions of Acetaminophen after the Introduction of Flow Restrictors.

J Pediatr 2018 07 2;198:254-259.e1. Epub 2018 Apr 2.

Rocky Mountain Poison and Drug Center, Denver Health and Hospital Authority, Denver, CO.

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http://dx.doi.org/10.1016/j.jpeds.2018.02.033DOI Listing
July 2018

Response by Brass and Hiatt to Letter Regarding Article, "Aspirin Monotherapy Should Not Be Recommended for Cardioprotection in Patients With Symptomatic Peripheral Artery Disease".

Circulation 2018 03;137(12):1304

Department of Medicine, Division of Cardiology, University of Colorado School of Medicine and CPC Clinical Research, Aurora (W.R.H.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.117.032707DOI Listing
March 2018

Aspirin Monotherapy Should Not Be Recommended for Cardioprotection in Patients With Symptomatic Peripheral Artery Disease.

Circulation 2017 08;136(9):785-786

From Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA (E.P.B.); and Department of Medicine, Division of Cardiology, University of Colorado School of Medicine and CPC Clinical Research, Aurora (W.R.H.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.117.028888DOI Listing
August 2017

Time Trends in Physician Visits for Gastroesophageal Reflux Disease Before and After the Rx-to-OTC Switch of Proton Pump Inhibitors.

J Clin Pharmacol 2017 04 6;57(4):452-458. Epub 2016 Oct 6.

Department of Medicine, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, USA.

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http://dx.doi.org/10.1002/jcph.825DOI Listing
April 2017

Noninferiority Doesn't Mean Not Inferior.

Clin Infect Dis 2016 Feb 20;62(4):525-6. Epub 2015 Oct 20.

Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California.

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http://dx.doi.org/10.1093/cid/civ895DOI Listing
February 2016

Pathogenesis of the limb manifestations and exercise limitations in peripheral artery disease.

Circ Res 2015 Apr;116(9):1527-39

From the Division of Cardiology, Department of Medicine (W.R.H., E.J.A.), CPC Clinical Research (W.R.H.), University of Colorado School of Medicine, Aurora; Cardiovascular & Metabolic Diseases Drug Discovery Unit, Takeda Pharmaceuticals, San Diego, CA (C.J.L.); and Department of Medicine, Harbor-UCLA Center for Clinical Pharmacology, Torrance, CA (E.P.B.).

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http://dx.doi.org/10.1161/CIRCRESAHA.116.303566DOI Listing
April 2015

Resident's morning report: an opportunity to reinforce principles of biomedical science in a clinical context.

Authors:
Eric P Brass

Biochem Mol Biol Educ 2013 Sep-Oct;41(5):315-8. Epub 2013 Sep 10.

Department of Medicine, Harbor-UCLA Medical Center, Torrance, California.

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http://dx.doi.org/10.1002/bmb.20714DOI Listing
December 2014

Patient and hospital-level characteristics associated with the use of do-not-resuscitate orders in patients hospitalized for sepsis.

J Gen Intern Med 2014 Sep 14;29(9):1256-62. Epub 2014 Jun 14.

Division of Respiratory and Critical Care Physiology and Medicine, Los Angeles Biomed Research Institute, Harbor-University of California Los Angeles Medical Center, Torrance, CA, USA,

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http://link.springer.com/content/pdf/10.1007/s11606-014-2906
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http://escholarship.org/uc/item/83223909.pdf
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http://link.springer.com/10.1007/s11606-014-2906-x
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http://dx.doi.org/10.1007/s11606-014-2906-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139525PMC
September 2014

The treadmill is a better functional test than the 6-minute walk test in therapeutic trials of patients with peripheral artery disease.

Circulation 2014 Jul;130(1):69-78

From the University of Colorado School of Medicine, Department of Medicine, Division of Cardiology and CPC Clinical Research, Aurora (W.R.H., R.K.R.); and Harbor-UCLA Centers for Clinical Pharmacology, Torrance, CA (E.P.B.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.113.007003DOI Listing
July 2014

Response to McDermott.

Circulation 2014 Jul;130(1):68

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July 2014

Association of clinical attributes and treadmill walking performance in patients with claudication due to peripheral artery disease.

J Vasc Surg 2013 Aug 16;58(2):396-403. Epub 2013 May 16.

Harbor-University of California Los Angeles (UCLA) Center for Clinical Pharmacology, Torrance, CA, USA.

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http://dx.doi.org/10.1016/j.jvs.2012.12.077DOI Listing
August 2013

Assessing the benefit-risk for new drugs: are the FDA's Endocrinologic and Metabolic Drugs Advisory Committee and the Division of Metabolism and Endocrinology Products in sync?

Authors:
Eric P Brass

Diabetes Care 2013 Jul 21;36(7):1823-6. Epub 2013 May 21.

Department of Medicine, Harbor-UCLA Medical Center, Torrance, California, USA.

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http://dx.doi.org/10.2337/dc13-0891DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3687289PMC
July 2013

Intermittent claudication: new targets for drug development.

Authors:
Eric P Brass

Drugs 2013 Jul;73(10):999-1014

Department of Medicine, Center for Clinical Pharmacology, Harbor-UCLA Medical Center, 1124 W Carson Street, Torrance, CA 90502, USA.

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http://dx.doi.org/10.1007/s40265-013-0078-3DOI Listing
July 2013

A decision-analysis tool for benefit-risk assessment of nonprescription drugs.

J Clin Pharmacol 2013 May 4;53(5):475-82. Epub 2013 Feb 4.

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http://dx.doi.org/10.1002/jcph.22DOI Listing
May 2013

From bad behaviour to bad biology: pitfalls and promises in the management of resistant hypertension.

Can J Cardiol 2013 May;29(5):549-56

Department of Medicine, Schulich School of Medicine and Dentistry, University of Western Ontario, Ontario, Canada.

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http://dx.doi.org/10.1016/j.cjca.2013.02.009DOI Listing
May 2013

A systematic review and meta-analysis of propionyl-L-carnitine effects on exercise performance in patients with claudication.

Vasc Med 2013 Feb 15;18(1):3-12. Epub 2013 Jan 15.

Harbor-UCLA Center for Clinical Pharmacology, Torrance, CA, USA.

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http://dx.doi.org/10.1177/1358863X12467491DOI Listing
February 2013

The influence of need for cognition and principal display panel factors on over-the-counter drug facts label comprehension.

Health Commun 2012 7;27(3):264-72. Epub 2011 Sep 7.

The Paul Merage School of Business, University of California, Irvine, CA 92697-3125, USA.

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http://dx.doi.org/10.1080/10410236.2011.578335DOI Listing
August 2012

Improving the FDA's advisory committee process.

J Clin Pharmacol 2012 Aug 10;52(8):1277-83. Epub 2011 Sep 10.

Harbor-UCLA Center for Clinical Pharmacology, Torrance, CA 90274, USA.

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http://dx.doi.org/10.1177/0091270011412962DOI Listing
August 2012

Risk factors for mortality in patients with mucormycosis.

Med Mycol 2012 Aug 21;50(6):611-8. Epub 2012 Mar 21.

Division of General Internal Medicine, Los Angeles Biomedical Research Institute, Harbor-University of California Los Angeles (UCLA) Medical Center, Los Angeles, CA, USA.

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http://dx.doi.org/10.3109/13693786.2012.669502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951871PMC
August 2012

The Deferasirox-AmBisome Therapy for Mucormycosis (DEFEAT Mucor) study: a randomized, double-blinded, placebo-controlled trial.

J Antimicrob Chemother 2012 Mar 20;67(3):715-22. Epub 2011 Sep 20.

Division of General Internal Medicine, Los Angeles Biomedical Research Institute, Harbor-University of California Los Angeles (UCLA) Medical Center, Torrance, CA, USA.

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http://dx.doi.org/10.1093/jac/dkr375DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383100PMC
March 2012

A phase II dose-ranging study of the phosphodiesterase inhibitor K-134 in patients with peripheral artery disease and claudication.

J Vasc Surg 2012 Feb 25;55(2):381-389.e1. Epub 2011 Nov 25.

Harbor-UCLA Center for Clinical Pharmacology, Torrance, CA 90502, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S074152141102081
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http://dx.doi.org/10.1016/j.jvs.2011.09.004DOI Listing
February 2012

Effect of propionyl-L-carnitine on a background of monitored exercise in patients with claudication secondary to peripheral artery disease.

J Cardiopulm Rehabil Prev 2011 Mar-Apr;31(2):125-32

University of Colorado School of Medicine, Division of Cardiology and CPC Clinical Research, Aurora, Colorado 80045, USA.

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http://dx.doi.org/10.1097/HCR.0b013e3181f1fd65DOI Listing
July 2011

Application of adaptive design and decision making to a phase II trial of a phosphodiesterase inhibitor for the treatment of intermittent claudication.

Trials 2011 May 25;12:134. Epub 2011 May 25.

Department of Emergency Medicine, Harbor-UCLA Medical Center, 1000 West Carson Street, Torrance, California 90509, USA.

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http://dx.doi.org/10.1186/1745-6215-12-134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3126735PMC
May 2011

Considerations in the development of drugs to treat sarcopenia.

J Am Geriatr Soc 2011 Mar 1;59(3):530-5. Epub 2011 Mar 1.

Department of Medicine, Harbor-University of California at Los Angeles Medical Center, Torrance, California, USA.

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http://dx.doi.org/10.1111/j.1532-5415.2010.03285.xDOI Listing
March 2011

Design of clinical trials of antibacterial agents for community-acquired bacterial pneumonia.

Clin Investig (Lond) 2011 Jan;1(1):19-32

Division of General Internal Medicine, Los Angeles Biomedical Research Institute (LA BioMed) at Harbor-University of California Los Angeles (UCLA) Medical Center, CA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173946PMC
January 2011

Basic biomedical sciences and the future of medical education: implications for internal medicine.

Authors:
Eric P Brass

J Gen Intern Med 2009 Nov 31;24(11):1251-4. Epub 2009 Oct 31.

Department of Medicine, Harbor-UCLA Medical Center and the David Geffen School of Medicine at UCLA, 1124 W. Carson Street, Torrance, CA 90502, USA.

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http://dx.doi.org/10.1007/s11606-009-0998-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771245PMC
November 2009

Temporal pattern of skeletal muscle gene expression following endurance exercise in Alaskan sled dogs.

J Appl Physiol (1985) 2009 Aug 4;107(2):605-12. Epub 2009 Jun 4.

Department of Medicine, Harbor-University of California Los Angeles Medical Center, 1124 W. Carson St., Torrance, CA 90502, USA.

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http://dx.doi.org/10.1152/japplphysiol.91347.2008DOI Listing
August 2009

Position paper: recommended design features of future clinical trials of antibacterial agents for community-acquired pneumonia.

Clin Infect Dis 2008 Dec;47 Suppl 3:S249-65

Infectious Diseases Society of America Antimicrobial Availability Task Force, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2827629PMC
December 2008

Long-term safety of cilostazol in patients with peripheral artery disease: the CASTLE study (Cilostazol: A Study in Long-term Effects).

J Vasc Surg 2008 Feb 26;47(2):330-336. Epub 2007 Dec 26.

Section of Vascular Medicine, Divisions of Geriatrics and Cardiology, University of Colorado School of Medicine C/O Colorado Prevention Center, Denver, CO 80203, USA.

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http://dx.doi.org/10.1016/j.jvs.2007.10.009DOI Listing
February 2008

American and German students' knowledge, perceptions, and behaviors with respect to over-the-counter pain relievers.

Health Psychol 2007 Nov;26(6):802-6

Department of Health Services, UCLA School of Public Health, University of California-Los Angeles, CA, USA.

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http://dx.doi.org/10.1037/0278-6133.26.6.802DOI Listing
November 2007

Skeletal muscle StO2 kinetics are slowed during low work rate calf exercise in peripheral arterial disease.

Eur J Appl Physiol 2007 May 20;100(2):143-51. Epub 2007 Feb 20.

Department of Medicine, University of Colorado at Denver Health Sciences Center, Box B-179, 4200 East Ninth Avenue, Denver, CO 80262, USA.

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http://dx.doi.org/10.1007/s00421-007-0412-0DOI Listing
May 2007

Adjunctive parenteral therapy with lipo-ecraprost, a prostaglandin E1 analog, in patients with critical limb ischemia undergoing distal revascularization does not improve 6-month outcomes.

J Vasc Surg 2007 May 9;45(5):953-60; discussion 960-1. Epub 2007 Mar 9.

University of Colorado Health Sciences Center and the Colorado Prevention Center, Denver, CO 80262-0302, USA.

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http://dx.doi.org/10.1016/j.jvs.2006.12.057DOI Listing
May 2007

Optimal assessment of baseline treadmill walking performance in claudication clinical trials.

Vasc Med 2007 May;12(2):97-103

Harbor-UCLA Center for Clinical Pharmacology, 1124 W Carson Street, Torrance, CA 90502, USA.

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http://dx.doi.org/10.1177/1358863X07078602DOI Listing
May 2007

The novel phosphodiesterase inhibitor NM-702 improves claudication-limited exercise performance in patients with peripheral arterial disease.

J Am Coll Cardiol 2006 Dec 28;48(12):2539-45. Epub 2006 Nov 28.

Department of Medicine, Harbor-UCLA Medical Center, Torrance, California 90502, USA.

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http://dx.doi.org/10.1016/j.jacc.2006.07.064DOI Listing
December 2006

Review of mortality and cardiovascular event rates in patients enrolled in clinical trials for claudication therapies.

Vasc Med 2006 Nov;11(3):141-5

Harbor-UCLA Center for Clinical Pharmacology, 1124 W. Carson Street, Torrance, CA 90502, USA.

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http://dx.doi.org/10.1177/1358863x06069513DOI Listing
November 2006

Risk assessment in drug development for symptomatic indications: a framework for the prospective exclusion of unacceptable cardiovascular risk.

Clin Pharmacol Ther 2006 Mar;79(3):165-72

Department of Medicine, Section of Vascular Medicine, University of Colorado Health Sciences Center, Colorado Prevention Center, and National Jewish Medical and Research Center, Denver, 80203, USA.

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http://dx.doi.org/10.1016/j.clpt.2005.11.012DOI Listing
March 2006

Potential impact on cardiovascular public health of over-the-counter statin availability.

Am J Cardiol 2006 Mar 30;97(6):851-6. Epub 2006 Jan 30.

Harbor-UCLA Center for Clinical Pharmacology, Torrance, California, USA.

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http://dx.doi.org/10.1016/j.amjcard.2005.10.022DOI Listing
March 2006

Consumer behavior in the setting of over-the-counter statin availability: lessons from the consumer use study of OTC Mevacor.

Authors:
Eric P Brass

Am J Cardiol 2004 Nov;94(9A):22F-29F

Department of Medicine, Center for Clinical Pharmacology, Harbor-UCLA Medical Center, Torrance, California 90502, USA.

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http://dx.doi.org/10.1016/j.amjcard.2004.07.051DOI Listing
November 2004

Carnitine and sports medicine: use or abuse?

Authors:
Eric P Brass

Ann N Y Acad Sci 2004 Nov;1033:67-78

Harbor-UCLA Center for Clinical Pharmacology, 1124 West Carson Street, Building J2, Torrance, CA 90502, USA.

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http://doi.wiley.com/10.1196/annals.1320.006
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http://dx.doi.org/10.1196/annals.1320.006DOI Listing
November 2004

Skeletal muscle metabolic changes in peripheral arterial disease contribute to exercise intolerance: a point-counterpoint discussion.

Vasc Med 2004 Nov;9(4):293-301

Center for Clinical Pharmacology, Department of Medicine, Harbor-UCLA Medical Center, Torrance, CA, USA.

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http://dx.doi.org/10.1191/1358863x04vm572raDOI Listing
November 2004

Impaired muscle oxygen use at onset of exercise in peripheral arterial disease.

J Vasc Surg 2004 Sep;40(3):488-93

University of Colorado Health Sciences Center, Denver 80262, USA.

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http://dx.doi.org/10.1016/j.jvs.2004.06.025DOI Listing
September 2004

Pulmonary VO2 dynamics during treadmill and arm exercise in peripheral arterial disease.

J Appl Physiol (1985) 2004 Aug 16;97(2):627-34. Epub 2004 Apr 16.

Section of Vascular Medicine, University of Colorado Health Sciences Center, Box B-179, 4200 East Ninth Ave., Denver, CO 80262, USA.

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http://dx.doi.org/10.1152/japplphysiol.00612.2003DOI Listing
August 2004

Differential management of cardiovascular disease in ESRD by nephrologists and cardiologists.

Am J Kidney Dis 2004 Aug;44(2):309-21

Division of Nephrology and Hypertension, Harbor-University of California, Los Angeles Research and Education Institute, Torrance, CA, USA.

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http://dx.doi.org/10.1053/j.ajkd.2004.04.036DOI Listing
August 2004

Implications of a switch from prescription to over-the-counter status for allergy drugs.

Authors:
Eric P Brass

Curr Allergy Asthma Rep 2004 May;4(3):245-50

Department of Medicine, Harbor-UCLA Center for Clinical Pharmacology, 1124 W. Carson Street, Tornace, CA 90502, USA.

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May 2004

Trends in antimicrobial drug development: implications for the future.

Clin Infect Dis 2004 May 14;38(9):1279-86. Epub 2004 Apr 14.

Research and Education Institute and Department of Medicine, Harbor-University of California, Los Angeles Medical Center, Torrance, California 90502, USA.

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https://academic.oup.com/cid/article-lookup/doi/10.1086/4209
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http://dx.doi.org/10.1086/420937DOI Listing
May 2004

Exercise capacity as a predictor of survival among ambulatory patients with end-stage renal disease.

Kidney Int 2004 Feb;65(2):719-24

Harbor-UCLA Research and Education Institute, Torrance, CA 90502, USA.

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http://dx.doi.org/10.1111/j.1523-1755.2004.00411.xDOI Listing
February 2004

Label development and the label comprehension study for over-the-counter drugs.

Clin Pharmacol Ther 2003 Nov;74(5):406-12

Department of Medicine, Center for Clinical Pharmacology, Harbor-UCLA Medical Center, Torrance, CA 90502, USA.

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http://dx.doi.org/10.1016/S0009-9236(03)00239-XDOI Listing
November 2003

Premature termination of clinical trials.

Authors:
Eric P Brass

JAMA 2003 Aug;290(5):595

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http://dx.doi.org/10.1001/jama.290.5.595-aDOI Listing
August 2003

Impact on carnitine homeostasis of short-term treatment with the pivalate prodrug cefditoren pivoxil.

Clin Pharmacol Ther 2003 Apr;73(4):338-47

Harbor-UCLA Center for Clinical Pharmacology, Torrance, CA 90502.

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http://dx.doi.org/10.1016/s0009-9236(02)17636-3DOI Listing
April 2003

Peripheral arterial disease is not associated with an increased prevalence of intradialytic cramps in patients on maintenance hemodialysis.

Am J Nephrol 2002 Sep-Dec;22(5-6):491-6

Department of Medicine, Harbor-UCLA Medical Center, Torrance, Calif. 90502, USA.

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http://dx.doi.org/10.1159/000065285DOI Listing
March 2003

Pivalate-generating prodrugs and carnitine homeostasis in man.

Authors:
Eric P Brass

Pharmacol Rev 2002 Dec;54(4):589-98

Department of Medicine, Harbor-University of California Los Angeles Medical Center, Torrance, California 90502, USA.

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December 2002

Synthetic peptides that exert antimicrobial activities in whole blood and blood-derived matrices.

Antimicrob Agents Chemother 2002 Dec;46(12):3883-91

Department of Medicine, Division of Infectious Diseases, Harbor-UCLA Medical Center, Research and Education Institute at Harbor-UCLA, Torrance, California 90502, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC132762PMC
http://dx.doi.org/10.1128/aac.46.12.3883-3891.2002DOI Listing
December 2002

Clinical and demographic predictors of exercise capacity in end-stage renal disease.

Am J Kidney Dis 2002 Jan;39(1):76-85

Department of Medicine, Harbor-UCLA Research and Education Institute, Torrance, CA, USA.

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http://dx.doi.org/10.1053/ajkd.2002.29884DOI Listing
January 2002

Stimulation of Lipogenesis by Interleukin-6 and Misoprostol-Free Acid in Isolated Rat Hepatocytes.

Am J Ther 1995 Sep;2(9):706-710

Departments of Medicine and Pharmacology, Case Western Reserve University, Cleveland, USA.

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September 1995