Publications by authors named "Eric H Raabe"

44Publications

Response to letter to the editor: "All models are wrong; some models are useful".

Neuro Oncol 2020 09;22(9):1406-1407

Department of Pathology, Division of Neuropathology, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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September 2020

MEK Inhibition Suppresses Growth of Atypical Teratoid/Rhabdoid Tumors.

J Neuropathol Exp Neurol 2020 07;79(7):746-753

Division of Pediatric Oncology, Department of Oncology.

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July 2020

Non-adhesive and highly stable biodegradable nanoparticles that provide widespread and safe transgene expression in orthotopic brain tumors.

Drug Deliv Transl Res 2020 06;10(3):572-581

Center for Nanomedicine at the Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.

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June 2020

Synergistic activity of mTORC1/2 kinase and MEK inhibitors suppresses pediatric low-grade glioma tumorigenicity and vascularity.

Neuro Oncol 2020 04;22(4):563-574

Johns Hopkins School of Medicine, Department of Pathology, Division of Neuropathology, Baltimore, Maryland.

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April 2020

PD-L1 Expression in Pediatric Low-Grade Gliomas Is Independent of BRAF V600E Mutational Status.

J Neuropathol Exp Neurol 2020 01;79(1):74-85

Division of Pediatric Oncology, Johns Hopkins School of Medicine, Sidney Kimmel Cancer Center, Baltimore, Maryland (AMM, EHR); Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, Minnesota (WRB); Department of Pathology, Division of Neuropathology, Johns Hopkins School of Medicine, Baltimore, Maryland (MY, BP, AA, LA, EHR, CGE); Department of Molecular and Cell Biology, The Johns Hopkins University, Krieger School of Arts and Sciences, Baltimore, Maryland (LH); Department of Oncology, Bloomberg-Kimmel Institute for Cancer Immunotherapy (ELE); and Department of Neurosurgery, Division of Neurosurgical Oncology (ML), Johns Hopkins School of Medicine, Baltimore, Maryland.

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January 2020

Orally bioavailable glutamine antagonist prodrug JHU-083 penetrates mouse brain and suppresses the growth of MYC-driven medulloblastoma.

Transl Oncol 2019 Oct 21;12(10):1314-1322. Epub 2019 Jul 21.

Division of Pediatric Oncology, Johns Hopkins University School of Medicine, Baltimore, MD; Department of Pathology, Johns Hopkins University, School of Medicine, Baltimore, MD 21287; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, School of Medicine, Baltimore, MD 21287. Electronic address:

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October 2019

An immunocompetent mouse model of human glioblastoma.

Oncotarget 2017 Sep 15;8(37):61072-61082. Epub 2017 May 15.

Russel H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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September 2017

The TORC1/2 inhibitor TAK228 sensitizes atypical teratoid rhabdoid tumors to cisplatin-induced cytotoxicity.

Neuro Oncol 2017 Oct;19(10):1361-1371

Division of Neuropathology and Sidney Kimmel Comprehensive Cancer Center and Division of Pediatric Oncology and Bloomberg Children's Hospital, Johns Hopkins Hospital, Baltimore, Maryland; St Jude Children's Research Hospital, Memphis, Tennessee.

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October 2017

The dual mTOR kinase inhibitor TAK228 inhibits tumorigenicity and enhances radiosensitization in diffuse intrinsic pontine glioma.

Cancer Lett 2017 08 25;400:110-116. Epub 2017 Apr 25.

Department of Pathology, Division of Neuropathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Division of Pediatric Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address:

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August 2017

The transcription factor Olig2 is important for the biology of diffuse intrinsic pontine gliomas.

Neuro Oncol 2017 08;19(8):1068-1078

Division of Oncology (J.L.A., R.M., N.O., A.L., S.S., R.D., M.F., L.M.C., L.H., M.D., B.D.), Experimental Hematology and Cancer Biology (R.R.W., J.W.), Pathology (L.M.), Developmental Biology, Center for Autoimmune Genomics and Etiology and Biomedical Informatics, Cincinnati Childrens Hospital Medical Center (CCHMC), Cincinnati, Ohio (M.L.W.); Division of Pediatric Oncology, Johns Hopkins University, Baltimore, Maryland (E.H.R.), Nemours Children’s Hospital, Orlando, Florida (L.M.)

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August 2017

The transcriptional modulator HMGA2 promotes stemness and tumorigenicity in glioblastoma.

Cancer Lett 2016 07 18;377(1):55-64. Epub 2016 Apr 18.

Division of Neuropathology and Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD 21287, USA; Division of Pediatric Oncology, Johns Hopkins University, Bloomberg Children's Hospital, Room 11379, 1800 Orleans St, Baltimore, MD 21287, USA. Electronic address:

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July 2016

Pediatric Brain Tumors: Current Knowledge and Therapeutic Opportunities.

J Pediatr Hematol Oncol 2016 05;38(4):249-60

Departments of †Genetics **Pediatrics ‡Geisel School of Medicine at Dartmouth, Norris Cotton Cancer Center, Hanover, NH *Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda §Division of Neuropathology and Sidney Kimmel Comprehensive Cancer Center ∥Division of Pediatric Oncology, Johns Hopkins School of Medicine, Bloomberg Children's Hospital, Baltimore, MD ¶The Brain Tumor Institute #Division of Hematology-Oncology, Children's National Medical Center, Washington, DC.

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May 2016

Diffusion tensor imaging suggests extrapontine extension of pediatric diffuse intrinsic pontine gliomas.

Eur J Radiol 2016 Apr 4;85(4):700-6. Epub 2016 Feb 4.

Section of Pediatric Neuroradiology, Division of Pediatric Radiology, Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address:

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April 2016

Alterations in cellular metabolome after pharmacological inhibition of Notch in glioblastoma cells.

Int J Cancer 2016 Mar 13;138(5):1246-55. Epub 2015 Oct 13.

Department of Pathology, Division of Neuropathology, Johns Hopkins Hospital, Baltimore, MD.

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March 2016

Disrupting NOTCH Slows Diffuse Intrinsic Pontine Glioma Growth, Enhances Radiation Sensitivity, and Shows Combinatorial Efficacy With Bromodomain Inhibition.

J Neuropathol Exp Neurol 2015 Aug;74(8):778-90

From the Division of Neuropathology and Sidney Kimmel Comprehensive Cancer Center (ICT, MH-C, WB, CGE, EHR) and Division of Pediatric Oncology (ICT, EHR), Johns Hopkins University, Bloomberg Children's Hospital, Baltimore, Maryland; Children's National Medical Center and George Washington University School of Medicine and Health Sciences, Washington, District of Columbia (MK, JN); Department of Neurology and Ophthalmology, Michigan State University, East Lansing (HTC); and Sparrow Health System, Lansing (HTC), Michigan; and Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (KEW).

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August 2015

The chromatin-modifying protein HMGA2 promotes atypical teratoid/rhabdoid cell tumorigenicity.

J Neuropathol Exp Neurol 2015 Feb;74(2):177-85

From the Division of Neuropathology and Sidney Kimmel Comprehensive Cancer Center (HK, MH-C, MFW, CGE, EHR), Division of Pediatric Oncology (EHR), Johns Hopkins University School of Medicine, Bloomberg Children's Hospital, Baltimore, Maryland; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina (YK, BEW); and Division of Hematology, Oncology, and Blood and Bone Marrow Transplant, Children's Hospital Los Angeles (JX, AE-E); and the University of Southern California (AE-E), Los Angeles, California.

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February 2015

ZEB1 Promotes Invasion in Human Fetal Neural Stem Cells and Hypoxic Glioma Neurospheres.

Brain Pathol 2015 Nov 8;25(6):724-32. Epub 2015 Feb 8.

Department of Pathology, Division of Neuropathology, Johns Hopkins Hospital, Baltimore, MD.

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November 2015

mTOR: a new therapeutic target for pediatric low-grade glioma?

CNS Oncol 2014 Mar;3(2):89-91

Division of Neuropathology, Johns Hopkins University, Baltimore, MD, USA.

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March 2014

Activation of mTORC1/mTORC2 signaling in pediatric low-grade glioma and pilocytic astrocytoma reveals mTOR as a therapeutic target.

Neuro Oncol 2013 Dec 6;15(12):1604-14. Epub 2013 Nov 6.

Corresponding Authors: Fausto J. Rodriguez, MD, Division of Neuropathology, Johns Hopkins Hospital, 1800 Orleans Street, Baltimore, MD 21231. Eric H. Raabe, MD, PhD, Division of Neuropathology, Johns Hopkins Hospital, 1800 Orleans Street, Baltimore, MD 21231

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December 2013

Methylome alterations "mark" new therapeutic opportunities in glioblastoma.

Cancer Cell 2012 Oct;22(4):417-8

Division of Pediatric Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

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October 2012

BRAF activation induces transformation and then senescence in human neural stem cells: a pilocytic astrocytoma model.

Clin Cancer Res 2011 Jun;17(11):3590-9

Division of Pediatric Oncology and Departments of Pathology and Pediatrics and Adolescent Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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June 2011

Subtotal splenic embolization is a safe and effective treatment for isolated splenic vascular tumors associated with consumptive coagulopathy.

J Pediatr Hematol Oncol 2011 Jul;33(5):383-6

Division of Pediatric Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

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July 2011

High-risk medulloblastoma: does c-myc amplification overrule histopathology?

Pediatr Blood Cancer 2010 Mar;54(3):344-5

Division of Pediatric Oncology, Johns Hopkins University School of Medicine, Baltimore, MD21287, USA.

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March 2010

Growth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASG.

Genes Dev 2004 May 22;18(9):1035-46. Epub 2004 Apr 22.

Division of Pediatric Oncology, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

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May 2004