Publications by authors named "Erhan Ayhan"

30 Publications

  • Page 1 of 1

The effect of secukinumab treatment on inflammatory parameters in patients with psoriasis: A multicentre restrospective study.

Int J Clin Pract 2021 Feb 24:e14114. Epub 2021 Feb 24.

Department of Dermatology, Van Training and Research Hospital, Van, Turkey.

Aim: Psoriasis is a common chronic inflammatory disease of the skin with remission and relapses. The aim of this study was to investigate the change in inflammatory parameters such as neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and mean platelet volume (MPV) in patients receiving secukinumab treatment for psoriasis vulgaris (PV).

Materials And Methods: In this retrospective study, we evaluated the laboratory results of 40 patients who were followed up with a diagnosis of PV and received secukinumab treatment in three different dermatology clinics between July 2018 and September 2019.

Results: Neutrophil count and leukocyte count were significantly decreased after secukinumab treatment. (P < .001) There was no statistically significant difference between lymphocyte count, platelet count, MPV, NLR and PLR values before treatment and at the 4th month of treatment (P values .230, .065, .110, .915 and .365, respectively).

Conclusion: In conclusion, it can be concluded that parameters such as NLR, PLR and MPV are not suitable parameters for monitoring the effects of secukinumab treatment on inflammation.
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http://dx.doi.org/10.1111/ijcp.14114DOI Listing
February 2021

Premature or nevoid sebaceous hyperplasia? Two case reports of a rare disease.

J Cosmet Dermatol 2021 Mar 23;20(3):835-837. Epub 2020 Dec 23.

Department of Pathology, University of Health Sciences Gazi Yaşargil Training and Research Hospital, Diyarbakır, Turkey.

Early or familial cases of sebaceous hyperplasia (SH) with multiple lesions, thought to be associated with genetic predisposition, have been reported in young individuals. Rarely reported variants include the giant, diffuse, zosteriform, and/or linear (nevoid) form. However, premature SH, defined as benign proliferation of sebaceous glands that occurs during or after puberty, is histologically similar to SH. Whether the definitions of nevoid SH or premature SH are the same remains unclear. We report two sporadic cases of premature SH.
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http://dx.doi.org/10.1111/jocd.13906DOI Listing
March 2021

COVID-19 infection under omalizumab therapy for chronic spontaneous urticaria: three cases.

Int J Dermatol 2021 Feb 17;60(2):253-254. Epub 2020 Dec 17.

Department of Infectious Diseases and Clinical Microbiology, Bismil State Hospital, Diyarbakır, Turkey.

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http://dx.doi.org/10.1111/ijd.15379DOI Listing
February 2021

Evaluation of inflammatory parameters in patients with cutaneous leishmaniasis.

Dermatol Ther 2021 Jan 7;34(1):e14603. Epub 2020 Dec 7.

Department of Microbiology, Harran University Medical Faculty, Sanlıurfa, Turkey.

Cutaneous leishmaniasis (CL) is a vector-borne parasitic disease characterized by various skin lesions that can cause deformities when healed. Our aim in this study is to show the utility of parameters such as neutrophil/lymphocyte ratio (NLR), thrombocyte/lymphocyte ratio (TLR), and mean thrombocyte volume (MTV) as auxiliary laboratory methods in CL patients. About 107 patients who were admitted to our dermatological and venereal diseases outpatient clinic between January 2018 and January 2019 and were diagnosed with CL by microscopic examination and 74 healthy individuals were included in the study. There were no significant differences between the patient and control group in terms of neutrophil counts, leukocyte counts, platelet counts, and NLR values (P values: .271, .053, .263, and .459, respectively). When the TLR and MTV values of patients with CL and those of the healthy controls were compared, it was found that TLR and MTV values were statistically higher in patients with CL (P values of .010 and .044, respectively). Based on these data, NLR was not considered to be a suitable parameter for demonstrating inflammation in CL patients, but TLR and MTV were held to be an appropriate parameter for demonstrating inflammation in CL patients. In addition, we think that the increase in MTV and TLR, can be used as an auxiliary laboratory test in the diagnosis of CL disease.
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http://dx.doi.org/10.1111/dth.14603DOI Listing
January 2021

Atypical and unusual morphological variants of cutaneous leishmaniasis.

Int J Clin Pract 2020 Oct 26:e13730. Epub 2020 Oct 26.

Department of Pathology, Harran University Medical Faculty, Sanliurfa, Turkey.

Objective: Cutaneous leishmaniasis (CL) is a skin disease characterised by prolonged nodulo-ulcerative lesions of the skin that heals with atrophic scar. Clinical features of CL vary depending on the type of parasite and host immune resistance. The aim of this study was to investigate the clinical features of atypical and unusual morphological variants of CL patients diagnosed in our clinic.

Materials And Methods: In this prospective study, 27 CL patients with atypical clinical features among 486 patients admitted to our clinic between July 2018 and September 2019 and diagnosed as CL by slit-skin smear examination or histopathological examination were included.

Results: Of 27 patients, 15 (55.5%) were male and 12 (44.5%) were female. The mean age of the patients was 25.8 ± 7.62 years. Seven (25.9%) patients had lupoid lesions, five (18.6%) patients had eczematoid lesions, four (14.8%) patients had lip lesions, three (11.1%) patients had erysipelas-like lesions, two (7.4%) patients had eyelid lesions, two (7.4%) patients had sporotrichoid lesions, two (7.4%) patients had verrucous lesions, one (3.7%) patient had psoriasiform lesion and one (3.7%) patient had paronychial lesion.

Conclusion: In conclusion, rare clinical forms of CL are presented in this study. It should be kept in mind that CL may have very different clinical features and should be considered in the differential diagnosis of eczema, psoriasis, erysipelas, sporotrichosis, paronychia and verrucous lesions.
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http://dx.doi.org/10.1111/ijcp.13730DOI Listing
October 2020

Isotretinoin does not alter VEGF-A and VEGF-C levels: do retinoids behave differently in dose-dependent and/or conditions?

Cutan Ocul Toxicol 2020 Dec 9;39(4):328-331. Epub 2020 Aug 9.

Department of Biochemistry, University of Health Sciences Gazi Yaşargil Trainning and Research Hospital, Diyarbakır, Turkey.

Background: It is seen that various forms of retinoids have different results on VEGF-A and VEGF-C levels when tested at different dosages, in different diseases and under different conditions such as or

Objective: To evaluate the effects of isotretinoin on VEGF-A and VEGF-C levels in humans.

Methods: Blood samples at the third month of the patient group and blood samples of the control group were compared in terms of VEGF-A and VEGF-C concentrations.

Results: No statistically significant difference was observed between the patient group and the control group in terms of VEGF-A and VEGF-C levels.

Limitations: Most of the patients discontinued treatment and could not reach the required number, the study was converted to case-control.

Conclusions: We think that 0.5 mg/kg/day isotretinoin has no effect on blood concentrations of VEGF-A and VEGF-C in humans. Therefore, there is a need for studies using isotretinoin in different doses and durations in humans in order to better evaluate its effects.
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http://dx.doi.org/10.1080/15569527.2020.1802743DOI Listing
December 2020

H syndrome: A rare genodermatosis.

J Cosmet Dermatol 2020 Sep 12;19(9):2449-2450. Epub 2020 Jul 12.

Department of Pathology, Dicle University Medical Faculty, Diyarbakır, Turkey.

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http://dx.doi.org/10.1111/jocd.13572DOI Listing
September 2020

Retinal nerve fiber layer, retinal pigment epithelium, and choroidal thickness in vitiligo patients.

J Cosmet Dermatol 2020 Nov 9;19(11):3032-3037. Epub 2020 Jun 9.

Department of Dermatology, University of Health Sciences Gazi Yaşargil Education Research Hospital, Diyarbakir, Turkey.

Background: Vitiligo is one of the common pigmentary disorders affecting the ocular structures.

Aim: To determine the retinal nerve fiber layer (RNFL), retinal pigment epithelium (RPE), and choroidal thickness (CT) in vitiligo patients and to evaluate the relationship between choroidal thickness and vitiligo subtypes.

Methods: The right eyes of 106 participants (51 vitiligo, 55 nonvitiligo) were included in the study. All of the participants underwent detailed eye examinations and spectral-domain optical coherence tomography (SD-OCT) examinations. CT was measured manually with enhanced depth imaging optical coherence tomography (Edi-OCT) (subfoveal [SubF], nasal n500 µm [N1], n1500 µm [N2]), and temporal (t500 µm [T1], t1500 µm [T2]).

Results: In vitiligo patients, CT values were significantly lower in the SubF, N1, N2, T1, and T2 areas compared to the control group (P = .001, P = .011, P = .002, P = .005, P ˂ .001, respectively). Periorbital involvement did not affect CT (P = .355, P = .746, P = .443, P = .633, P = .558, respectively). However, in patients with periorbital region involvement, the CT was significantly reduced if the lesion had a universal character (P ˂ .001, P = .001, P = .011, P ˂ .001, P = .002, respectively). It was observed that RPE thickness decreased in vitiligo, but this difference was not statistically significant (P = .140). RNFL thickness was unaffected in all quadrants. A positive correlation (r = .286, r = .280, respectively) was observed between the Vitiligo Area Severity Index (VASI) and age and disease duration. A negative correlation (r = -.360, r = -.316, r = -.315, r = -.313, respectively) was found in the CT of the SubF, N1, N2, T1, and T2 areas.

Conclusion: Vitiligo patients should be closely monitored for possible posterior ocular segment disorders.
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http://dx.doi.org/10.1111/jocd.13367DOI Listing
November 2020

Potential role of anti-interleukin-17 in COVID-19 treatment.

Dermatol Ther 2020 Jul 20;33(4):e13715. Epub 2020 Jun 20.

Department of Internal Medicine, University of Health Sciences Gazi Yaşargil Trainning and Research Hospital, Diyarbakır, Turkey.

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http://dx.doi.org/10.1111/dth.13715DOI Listing
July 2020

Spontaneous resolution of human papillomavirus infection in a patient with psoriasis given secukinumab.

Int J Dermatol 2020 Jul 2;59(7):e256-e257. Epub 2020 May 2.

Department of Dermatology, Şanlıurfa Education and Research Hospital, Şanlıurfa, Turkey.

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http://dx.doi.org/10.1111/ijd.14910DOI Listing
July 2020

Systemic isotretinoin therapy in the era of COVID-19.

Dermatol Ther 2020 Jul 20;33(4):e13482. Epub 2020 May 20.

Department of Dermatology, University of Rome G. Marconi, Rome, Italy.

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http://dx.doi.org/10.1111/dth.13482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261989PMC
July 2020

First clinical picture of a very rare disease: Primary cutaneous adenomyoepithelioma.

J Cosmet Dermatol 2020 Sep 12;19(9):2444-2446. Epub 2020 Apr 12.

Department of Dermatology, Van Training and Research Hospital, University of Health Sciences, Van, Turkey.

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http://dx.doi.org/10.1111/jocd.13408DOI Listing
September 2020

Effect of isotretinoin (13-cis-retinoic acid) on levels of soluble VEGF receptors (sVEGFR1, sVEGFR2, sVEGFR3) in patients with acne vulgaris.

J Dermatolog Treat 2020 Feb 20:1-5. Epub 2020 Feb 20.

Department of Internal Medicine, University of Health Sciences Gazi Yaşargil Trainning and Research Hospital, Diyarbakır, Turkey.

The effect of isotretinoin on soluble VEGFRs has not been previously investigated. This study evaluate the effects of isotretinoin (13-cis-retinoic acid) on soluble VEGFR1 (sVEGFR1), soluble VEGFR2 (sVEGFR2) and soluble VEGFR3 (sVEGFR3). The study included 38 patients (28 females, 10 males) receiving systemic isotretinoin treatment and 38 healthy individuals (28 females, 10 males) with similar age and gender characteristics. The blood samples of the patient group at third months and blood samples of the control group were compared in terms of sVEGFR1, sVEGFR2 and sVEGFR3 concentrations. It was significant that sVEGFR1 was low and sVEGFR3 was high in patients receiving isotretinoin (: .038, : .021, respectively). There was no significant change in sVEGFR2 levels between the groups (: .519). We think that the effect of isotretinoin on sVEGFR1, sVEGFR2 and sVEGFR3 may be secondary to its effects on the VEGF family. However, after clarifying the effect of isotretinoin on the VEGF family, we think that it can be used in some tumors and vascular diseases.
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http://dx.doi.org/10.1080/09546634.2020.1729331DOI Listing
February 2020

Low dose of isotretinoin: A comprehensive review.

Dermatol Ther 2020 03 20;33(2):e13251. Epub 2020 Feb 20.

Treatwell Skin Centre, Jammu, India.

Isotretinoin is a first-generation retinoid initially approved for the treatment of severe cases of acne vulgaris (nodulocystic acne). Because of its broad anti-inflammatory and immunomodulatory properties, it has been used beyond its initial approval in a myriad of other indications. Adverse effects of isotretinoin vary from xerosis to teratogenicity. Herein, we reviewed the literature, through date-unlimited PubMed search, from inception till December 2019, using the following search terms: "low-dose isotretinoin" and "dermatology," "isotretinoin and safety," "isotretinoin, off-label uses," "isotretinoin and male fertility," "isotretinoin, iPLEDGE system," aiming to deliver a therapeutic update relevant to clinical practice. All English-language articles were considered with no limitation based on the articles' type. Low-dose isotretinoin is not limited to old and novel dermatological conditions, but also showed promising results in the field of infertility and safety in the field of gastroenterology. We also highlight on the safety profile of the drug and experts' recommendations to enhance safety measures to decrease fetal risk while on isotretinoin.
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http://dx.doi.org/10.1111/dth.13251DOI Listing
March 2020

Dermoscopy of oral mucocele: three types of extravasation mucoceles

Turk J Med Sci 2020 02 13;50(1):96-102. Epub 2020 Feb 13.

Department of Pathology, Selahaddin Eyyubi State Hospital, Diyarbakır, Turkey

Background/aim: Dermoscopy is a diagnostic tool that assists in imaging the epidermis and dermis. Although it has also started to be used to diagnose nonmelanocytic lesions recently, it has not been tested much on oral mucosal masses, such as oral mucoceles. This study aimed to investigate whether dermoscopy is a valuable tool in diagnosing oral mucoceles.

Materials And Methods: In this study, the clinical and dermoscopic features of 21 oral mucocele lesions of 21 patients (11 females, 10 males) aged between 6 and 38 years who were confirmed histopathologically were evaluated.

Results: Of the lesions studied, 95.2% (20) were extravasation and 4.8% (1) were retention mucoceles. The nonvascular structures were determined as white areas (61.9%, 13), erythema (57.1%, 12), purplish-gray background (52.3%, 11), ulcer (30%, 8), yellowish- orange areas (23.8%, 5), crust (14.2%, 3), starburst pattern (0.95%, 2), and bleeding (0.47%, 1). Dermoscopically, 40% of extravasation mucoceles were classified as type 1 (8 patients), 25% as type 2 (5 patients), and 35% as type 3 (7 patients).

Conclusion: We concluded that there are 3 types of extravasation mucoceles dermoscopically and clinically, and these types may be stages of transition between each other.
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http://dx.doi.org/10.3906/sag-1907-56DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080353PMC
February 2020

Dermoscopy of oral mucocele: three types of extravasation mucoceles

Turk J Med Sci 2020 02 13;50(1):96-102. Epub 2020 Feb 13.

Department of Pathology, Selahaddin Eyyubi State Hospital, Diyarbakır, Turkey

Background/aim: Dermoscopy is a diagnostic tool that assists in imaging the epidermis and dermis. Although it has also started to be used to diagnose nonmelanocytic lesions recently, it has not been tested much on oral mucosal masses, such as oral mucoceles. This study aimed to investigate whether dermoscopy is a valuable tool in diagnosing oral mucoceles.

Materials And Methods: In this study, the clinical and dermoscopic features of 21 oral mucocele lesions of 21 patients (11 females, 10 males) aged between 6 and 38 years who were confirmed histopathologically were evaluated.

Results: Of the lesions studied, 95.2% (20) were extravasation and 4.8% (1) were retention mucoceles. The nonvascular structures were determined as white areas (61.9%, 13), erythema (57.1%, 12), purplish-gray background (52.3%, 11), ulcer (30%, 8), yellowish- orange areas (23.8%, 5), crust (14.2%, 3), starburst pattern (0.95%, 2), and bleeding (0.47%, 1). Dermoscopically, 40% of extravasation mucoceles were classified as type 1 (8 patients), 25% as type 2 (5 patients), and 35% as type 3 (7 patients).

Conclusion: We concluded that there are 3 types of extravasation mucoceles dermoscopically and clinically, and these types may be stages of transition between each other.
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http://dx.doi.org/10.3906/sag-1907-56DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080353PMC
February 2020

Clarifying the dermoscopic features of irritation fibroma by mobile photograph editor application.

Skin Res Technol 2019 Sep 17;25(5):768-769. Epub 2019 May 17.

Department of Otorhinolaryngology, University of Health Sciences Haydarpaşa Numune Education and Research Hospital, İstanbul, Turkey.

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http://dx.doi.org/10.1111/srt.12715DOI Listing
September 2019

Enhancing the appearance of vessels in dermoscopic images via a mobile photo editor application.

J Am Acad Dermatol 2020 Jan 10;82(1):e11-e12. Epub 2019 May 10.

Department of Otorhinolaryngology, University of Health Sciences Gazi Yaşargil Training and Research Hospital, Diyarbakır, Turkey.

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http://dx.doi.org/10.1016/j.jaad.2019.05.008DOI Listing
January 2020

Dermoscopic features and types of orf and milker's nodule.

Postepy Dermatol Alergol 2017 Aug 2;34(4):357-362. Epub 2017 Aug 2.

Department of Dermatology, Diyarbakır Ergani State Hospital, Diyarbakır, Turkey.

Introduction: Orf and milker's nodule are zoonotic cutaneous diseases generated by parapoxviruses. Contribution of dermoscopy to the diagnosis of these diseases has not been studied in the medical literature as to our knowledge.

Aim: To investigate whether dermoscopy is a valuable diagnostic tool in orf and milker's nodule diagnosis or not.

Material And Methods: In this study, macroscopic and dermoscopic features have been evaluated by including 46 lesions of 32 patients who have orf and milker's nodule.

Results: 56.5% (26) of lesions were orf, while 43.5% (20) of lesions were milker's nodule (MN). Non-vascular dermoscopic structures have been determined as follows: blue-gray area (23.1% of orf, 35% of MN), orange-yellow streaks (19.2% of orf, 19.2% of MN), grayish-whitish streaks (26.9% of orf, 55% of MN), central yellow-white area (26.9% of orf, 35% of MN), crust (46.2% of orf, 40% of MN), erosion-ulceration (69.2% of orf, 55% of MN), yellow-white globule (11.5% of orf, 15% of MN), and yellow-white ring (57.7% of orf, 35% of MN). Limitations: Lack of PCR analysis, based of patient anamnesis types of orf and milker's nodule.

Conclusions: No significant dermoscopic differences have been determined between orf and milker's nodule patients' lesions. In our opinion, dermoscopy may be a useful tool to develop diagnosis of these diseases.
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http://dx.doi.org/10.5114/ada.2017.69317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560185PMC
August 2017

Lymphangioma Circumscriptum: Good Clinical Response to Isotretinoin Therapy.

Authors:
Erhan Ayhan

Pediatr Dermatol 2016 May 4;33(3):e208-9. Epub 2016 Apr 4.

Department of Dermatology, Tokat Zile State Hospital, Tokat, Turkey.

Lymphangioma circumscriptum (LC) is a superficial form of lymphatic malformation that can be difficult to treat. Therapeutic approaches to LC such as laser therapy, sclerotherapy, and surgical excision give varying results. This is the first description of a case of LC successfully treated with oral isotretinoin. Further studies are needed to confirm whether this is a reproducible treatment option.
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http://dx.doi.org/10.1111/pde.12839DOI Listing
May 2016

Vascular structures in dermoscopy.

An Bras Dermatol 2015 Jul-Aug;90(4):545-53

Faculty of Medicine, Dicle University, Diyarbakır, TR.

Dermoscopy is an aiding method in the visualization of the epidermis and dermis. It is usually used to diagnose melanocytic lesions. In recent years, dermoscopy has increasingly been used to diagnose non-melanocytic lesions. Certain vascular structures, their patterns of arrangement and additional criteria may demonstrate lesion-specific characteristics. In this review, vascular structures and their arrangements are discussed separately in the light of conflicting views and an overview of recent literature.
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http://dx.doi.org/10.1590/abd1806-4841.20153452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560544PMC
March 2016

Epidermal cyst mimicking incision line metastasis.

Turk J Surg 2017 2;33(2):133-134. Epub 2015 Jul 2.

Clinic of General Surgery, Mersin University School of Medicine, Mersin, Turkey.

Epidermal cysts are cystic tumors lined with keratinized squamous layer and filled with keratin debris. Epidermal cysts may develop by implantation of surface epidermal layer into the dermis or subcutaneous tissue after trauma or surgical procedures. Cervix cancer spreads either directly or via the vascular and lymphatic systems. Distant skin metastasis of endometrium or cervix cancer is very rare. In this case report, a patient who had a history of cervix cancer operation 11 years ago and presented with a mass that mimicked incision line metastasis and was histopathologically diagnosed with epidermal cyst is presented.
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http://dx.doi.org/10.5152/UCD.2015.2927DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508240PMC
July 2015

A case of multiple eccrine hidrocystoma successfully treated with oral oxybutynin.

Authors:
Erhan Ayhan

Dermatol Ther 2015 May-Jun;28(3):107-9. Epub 2015 Mar 5.

Department of Dermatology, Tokat Zile State Hospital, Tokat, Turkey.

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http://dx.doi.org/10.1111/dth.12206DOI Listing
March 2016

Clinical and dermoscopic evaluation of cutaneous leishmaniasis.

Int J Dermatol 2015 Feb 10;54(2):193-201. Epub 2014 Sep 10.

Department of Dermatology, Tokat Zile State Hospital, Tokat, Turkey.

Background: Dermoscopy is a method to aid in the visualization of the epidermis and dermis. In recent years, the use of dermoscopy in the diagnosis of non-melanocytic lesions such as those of leishmania cutis has increased.

Objectives: This study was intended to establish whether dermoscopic investigation has any diagnostic value in cutaneous leishmaniasis (CL).

Methods: Fifty-five patients diagnosed with CL at the Department of Dermatology, Faculty of Medicine, Dicle University, between February and October 2012, were included in the study. Collectively, the patients exhibited a total of 127 lesions.

Results: The mean ± standard deviation age of the patients was 25.7 ± 21.3 years (range: 4-86 years). Twenty-three (41.8%) patients were male, and 32 (58.2%) were female. In dermoscopy, teardrop-like structures were observed in 42.5% of the lesions. Vascular structures were detected in 115 (90.6%) lesions; no vascular structures were observed in 12 (9.4%) lesions. Branching, linear, comma-like, and polymorphic vessels were seen more commonly in lesions on the face; pin-point and hairpin-like vessels were seen more commonly in lesions on the upper extremities.

Conclusions: When the findings obtained in this study were evaluated along with those reported in the literature, it became apparent that follicular plugs, also called "teardrop-like structures", seen on the face and neck may be a dermoscopic feature specific to CL. As hairpin-like vessels seen in an asymmetric radial arrangement were often observed on parts of the body other than the face, further dermoscopic studies comparing the lesions of CL with other ulcerating lesions are necessary.
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http://dx.doi.org/10.1111/ijd.12686DOI Listing
February 2015

Three different dermoscopic view of three new cases with pilomatrixoma.

Int J Trichology 2014 Jan;6(1):21-2

Department of General Surgery, Zile State Hospital, Tokat, Turkey.

Pilomatrixoma is a benign soft tissue neoplasm originated from follicular matrix of hair and is also known as Malherbe's calcified epithelioma. Some lesions are located on the skin and are usually misdiagnosed. A small number of patients had been dermoscopically examined. In this article, three patients of pilomatrixoma who had three different dermoscopic views were evaluated and discussed in concordance with the literature.
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http://dx.doi.org/10.4103/0974-7753.136753DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124689PMC
January 2014

Rapid and easy diagnosis of Netherton syndrome with dermoscopy.

J Cutan Med Surg 2014 Jul-Aug;18(4):280-2

Background: Netherton syndrome is a rare autosomal recessive disease demonstrating ichthyosis linearis circumflexa, atopic findings, and hair shaft anomalies. Trichorrhexis invaginata is the pathognomonic hair shaft anomaly seen in this syndrome.

Objective: In recent years, hair shaft anomalies have been described as "matchstick" and "golf tee" signs. We present a patient with Netherton syndrome diagnosed by the presence of matchstick and golf tee hairs in addition to trichorrhexis invaginata.
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http://dx.doi.org/10.2310/7750.2013.13106DOI Listing
September 2014

Results of patch testing in pediatric patients with plantar dermatitis and literature review.

Turk J Pediatr 2014 Mar-Apr;56(2):160-5

Department of Dermatology, Dicle University Faculty of Medicine, Diyarbakır, Turkey.

We aimed to determine the frequency of positive patch test reactions in pediatric patients with plantar dermatitis. Children diagnosed as inflammatory dermatitis of the plantar foot were included. Demographic and clinical characteristics of the patients were recorded, and patch testing was done using the European standard series antigens. Seventeen patients (9 females, 8 males) were included in the study. Ages of the patients ranged from 4-13 years, and the median age was 7.0. Seven patients had one to three positive reactions, seven had all negative reactions, one showed angry back syndrome, and results of two could not be assessed. Dermatitis of the feet is not rare in pediatric patients, and a significant percentage of these patients will be diagnosed as allergic contact dermatitis (ACD) if detailed and appropriate patch testing is done.
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March 2016

Presentation of three cases with phyto contact dermatitis caused by Ranunculus and Anthemis genera.

J Dermatolog Treat 2014 Dec 5;25(6):467-9. Epub 2013 Nov 5.

Department of Dermatology, Faculty of Medicine, Dicle University , Diyarbakir , Turkey.

In addition to being used especially in a systematic way, herbal treatments are preferred topically by the elderly population in some rheumatological and dermatological diseases. Although alternative medicine treatments may have beneficial effects, certain plants are known to cause common contact dermatitis. Protoanemonin and sesquiterpene lactones, which are found in such plant types as respectively Ranunculus and Anthemis, often cause contact dermatitis. In this article, three cases of phyto contact dermatitis, which are the result of topical use of plant types of Ranunculus ve Anthemis as an alternative method of treatment due to myalgia or arthralgia, have been presented.
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http://dx.doi.org/10.3109/09546634.2013.849792DOI Listing
December 2014

Vesiculobullous dermatomyositis with sensory motor neuropathy.

Skinmed 2013 May-Jun;11(3):185-7

Department of Dermatology, Dicle University School of Medicine, Diyarbakir, Turkey.

A 74-year-old man presented with muscle weakness in both legs for a duration of 2 months. Physical examination revealed periorbital edema and erythema, erythema on the neck and chest, erythematous papules on the proximal-distal interphalangeal and metocarpophalangeal joints, crusted plaque lesions on the thighs and around the knees, and bullous and ulcerated lesions in the antecubital and popliteal fossae (Figure 1A and 1B). Some bullous lesions were intact and some were ulcerated. There was severe edema especially in the upper extremities. He had a history of 15-kg weight loss for 4 months. Laboratory findings were remarkable for a white blood cell count of 16.0 K/UL (4.60-10.20 K/UL), a C-reactive protein of 6.93 mg/dL (0-0.5 mg/dL), an erythrocyte sedimentation rate of 50 mm/h (8-15 mm/h), an aspartate aminotransferase level of 213 U/L (10-40 U/L), a lactate dehydrogenase of 447 U/L (< 225 U/L), and a creatine kinase level of 1733 U/L (29-200 U/L). Results from antinuclear antibody at 1:320 titers and anti-smooth muscle antibody were positive. Results from anti-SS A/SS B antibodies, anti Jo-1 antibody, U1-snRNP antibody, and anti-ds DNA antibody tests were negative. A skin biopsy specimen obtained from the right antecubital fossa showed minimal orthokeratosis and subepidermal detachments. There was marked edema in the dermis and lymphocyte infiltration around the skin appendages (Figure 2). Direct immunofluorescence studies demonstrated scattered staining for C3 and IgM at the basal membrane zone. Results for IgG, IgA, and fibrin staining were negative. Muscle biopsy from left deltoid muscle was performed and some muscle fibers were demonstrated to be atrophied. There was remarkable difference between muscle fiber diameters. With Masson staining, there was increased connective tissue and no inflammation. Electromyography (EMG) showed a myogenic pattern. Nerve conduction studies showed tibial, median, ulnar, peroneal motor neuropathy, and median, ulnar, and sural sensory neuropathy. Based on these findings, diagnosis of vesiculo-bullous dermatomyositis (DM) was made. Further investigation of esophagogastroduodenoscopy with biopsy revealed ulcerated lesions on antrum and corpus and these were assessed as Helicobacter pylori-negative atrophic chronic gastritis. No pathologic findings were described on chest, abdomen, and pelvic tomography. Levels of tumor markers were within normal ranges. Overall, no sign of malignancy was detected. Methyl prednisolone treatment of 1 mg/kg/d was started; however, new bullous lesions erupted while the original lesions were healing.
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August 2013

Burns due to wet wood ash: three cases.

Cutan Ocul Toxicol 2014 Mar 17;33(1):85-6. Epub 2013 Jul 17.

Department of Dermatology, Tokat Zile State Hospital , Tokat , Turkey and.

Wood ash, a traditional multipurpose agent, is sometimes used under occlusion as a folkloric prescription to ease pain and edema. Adding water or oil to ash forms a mixture with strong alkaline properties. We present three interesting cases who sustained full-thickness burns after application of a poultice of wetted wood ash for the treatment of leg pain.
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http://dx.doi.org/10.3109/15569527.2013.814138DOI Listing
March 2014