Publications by authors named "Enzo Agostinelli"

76Publications

Nanotechnology-Based Strategies to Develop New Anticancer Therapies.

Biomolecules 2020 May 8;10(5). Epub 2020 May 8.

Department of Comparative Biomedicine and Food Science, University of Padua, Viale dell'Università 16, 35020 Legnaro (PD), Italy.

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http://dx.doi.org/10.3390/biom10050735DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278173PMC
May 2020

Biochemical and pathophysiological properties of polyamines.

Authors:
Enzo Agostinelli

Amino Acids 2020 Feb 18;52(2):111-117. Epub 2020 Feb 18.

Department of Biochemical Sciences, A. Rossi Fanelli', Sapienza University of Rome, Piazzale Aldo Moro 5, 00185, Rome, Italy.

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http://dx.doi.org/10.1007/s00726-020-02821-8DOI Listing
February 2020

Phenformin Inhibits Hedgehog-Dependent Tumor Growth through a Complex I-Independent Redox/Corepressor Module.

Cell Rep 2020 02;30(6):1735-1752.e7

Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy; Istituto Pasteur, Fondazione Cenci-Bolognetti, Sapienza University of Rome, 00161 Rome, Italy; International Polyamines Foundation-ONLUS, 00159 Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2020.01.024DOI Listing
February 2020

Polyamines: The possible missing link between mental disorders and epilepsy (Review).

Int J Mol Med 2020 01 11;45(1):3-9. Epub 2019 Nov 11.

Department of Science, University of Rome 'Roma Tre', I‑00146 Rome, Italy.

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http://dx.doi.org/10.3892/ijmm.2019.4401DOI Listing
January 2020

Involvement of the biogenic active amine agmatine in mitochondrial membrane permeabilization and release of pro-apoptotic factors.

Amino Acids 2020 Feb 25;52(2):161-169. Epub 2019 Oct 25.

Department of Biochemical Sciences, "A. Rossi-Fanelli", Sapienza University of Rome, 00135, Rome, Italy.

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http://link.springer.com/10.1007/s00726-019-02791-6
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http://dx.doi.org/10.1007/s00726-019-02791-6DOI Listing
February 2020

Link between spermine oxidase and apoptosis antagonizing transcription factor: A new pathway in neuroblastoma.

Int J Oncol 2019 Nov 13;55(5):1149-1156. Epub 2019 Sep 13.

International Polyamines Foundation - ONLUS, I-00159 Rome, Italy.

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http://dx.doi.org/10.3892/ijo.2019.4878DOI Listing
November 2019

The investigation of structure-activity relationship of polyamine-targeted synthetic compounds from different chemical groups.

Amino Acids 2020 Feb 13;52(2):199-211. Epub 2019 Sep 13.

Department of Biochemical Sciences, SAPIENZA University of Rome, Piazzale Aldo Moro 5, 00185, Rome, Italy.

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http://dx.doi.org/10.1007/s00726-019-02778-3DOI Listing
February 2020

A novel comprehensive paradigm for the etiopathogenesis of multiple sclerosis: therapeutic approaches and future perspectives on its treatment.

Amino Acids 2019 May 18;51(5):745-759. Epub 2019 Mar 18.

Department of Biochemical Sciences "A. Rossi Fanelli", Sapienza University of Rome, Piazzale Aldo Moro, 5, 00185, Rome, Italy.

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http://dx.doi.org/10.1007/s00726-019-02718-1DOI Listing
May 2019

Enzyme self-assembly on naked iron oxide nanoparticles for aminoaldehyde biosensing.

Amino Acids 2019 Apr 6;51(4):679-690. Epub 2019 Feb 6.

Department of Comparative Biomedicine and Food Science, University of Padua, Agripolis-Viale dell'Università 16, 35020, Legnaro, PD, Italy.

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http://dx.doi.org/10.1007/s00726-019-02704-7DOI Listing
April 2019

Endogenous and food-derived polyamines: determination by electrochemical sensing.

Amino Acids 2018 Sep 21;50(9):1187-1203. Epub 2018 Jul 21.

Department of Comparative Biomedicine and Food Science, University of Padua, Legnaro, PD, Italy.

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http://dx.doi.org/10.1007/s00726-018-2617-4DOI Listing
September 2018

The antioxidant, aged garlic extract, exerts cytotoxic effects on wild-type and multidrug-resistant human cancer cells by altering mitochondrial permeability.

Int J Oncol 2018 Sep 22;53(3):1257-1268. Epub 2018 Jun 22.

Department of Biochemical Sciences 'A. Rossi Fanelli', Sapienza University of Rome, I-00185 Rome, Italy.

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http://dx.doi.org/10.3892/ijo.2018.4452DOI Listing
September 2018

Spectroscopic and calorimetric characterization of spermine oxidase and its association forms.

Biochem J 2017 Dec 14;474(24):4253-4268. Epub 2017 Dec 14.

Department of Sciences, Roma Tre University, Viale Guglielmo Marconi 446, Rome I-00146, Italy

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http://dx.doi.org/10.1042/BCJ20170744DOI Listing
December 2017

Trophic and neurotrophic factors in human pituitary adenomas (Review).

Int J Oncol 2017 Oct 5;51(4):1014-1024. Epub 2017 Sep 5.

Department of Systems' Medicine, Division of Neurosurgery, University of Rome 'Tor Vergata', Rome, Italy.

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http://dx.doi.org/10.3892/ijo.2017.4120DOI Listing
October 2017

Radiolabeling of VEGF165 with 99mTc to evaluate VEGFR expression in tumor angiogenesis.

Int J Oncol 2017 Jun 8;50(6):2171-2179. Epub 2017 May 8.

Nuclear Medicine Unit, Department of Medical-Surgical Sciences and of Translational Medicine, Faculty of Medicine and Psychology, 'Sapienza' University of Rome, Rome, Italy.

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http://dx.doi.org/10.3892/ijo.2017.3989DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6903896PMC
June 2017

Management of anterior chamber dislocation of a dexamethasone intravitreal implant: a case report.

J Med Case Rep 2016 Oct 13;10(1):282. Epub 2016 Oct 13.

Department of Sense Organs, Faculty of Medicine and Dentistry, Sapienza University of Rome, Viale del Policlinico, 00161, Rome, Italy.

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http://dx.doi.org/10.1186/s13256-016-1077-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062904PMC
October 2016

Polyamines and transglutaminases: future perspectives.

Authors:
Enzo Agostinelli

Amino Acids 2016 10;48(10):2273-81

Department of Biochemical Sciences "A. Rossi Fanelli", SAPIENZA University of Rome, Piazzale Aldo Moro 5, 00185, Rome, Italy.

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http://dx.doi.org/10.1007/s00726-016-2326-9DOI Listing
October 2016

Milestones and recent discoveries on cell death mediated by mitochondria and their interactions with biologically active amines.

Amino Acids 2016 10 12;48(10):2313-26. Epub 2016 Sep 12.

Department of Biochemical Sciences, University of Rome "La Sapienza", Piazzale Aldo Moro 5, 00185, Rome, Italy.

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http://dx.doi.org/10.1007/s00726-016-2323-zDOI Listing
October 2016

Ser/Thr kinases and polyamines in the regulation of non-canonical functions of elongation factor 1A.

Amino Acids 2016 10 27;48(10):2339-52. Epub 2016 Aug 27.

Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Via S. Pansini 5, 8031, Naples, Italy.

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http://dx.doi.org/10.1007/s00726-016-2311-3DOI Listing
October 2016

Stability of spermine oxidase to thermal and chemical denaturation: comparison with bovine serum amine oxidase.

Amino Acids 2016 10 13;48(10):2283-91. Epub 2016 Jun 13.

Department of Biochemical Sciences "A. Rossi Fanelli", SAPIENZA University of Rome, Piazzale Aldo Moro 5, 00185, Rome, Italy.

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http://dx.doi.org/10.1007/s00726-016-2273-5DOI Listing
October 2016

VEGF in nuclear medicine: Clinical application in cancer and future perspectives (Review).

Int J Oncol 2016 Aug 1;49(2):437-47. Epub 2016 Jun 1.

Department of Sensory Organs, 'Sapienza' University, Rome, Italy.

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http://dx.doi.org/10.3892/ijo.2016.3553DOI Listing
August 2016

Spermine cycling in mitochondria is mediated by adenine nucleotide translocase activity: mechanism and pathophysiological implications.

Amino Acids 2016 10 2;48(10):2327-37. Epub 2016 Jun 2.

Department of Biochemical Sciences, SAPIENZA University of Rome, Piazzale Aldo Moro 5, 00185, Rome, Italy.

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http://dx.doi.org/10.1007/s00726-016-2264-6DOI Listing
October 2016

New trans dichloro (triphenylphosphine)platinum(II) complexes containing N-(butyl),N-(arylmethyl)amino ligands: Synthesis, cytotoxicity and mechanism of action.

Bioorg Med Chem 2016 07 2;24(13):2929-2937. Epub 2016 May 2.

Dipartimento di Chimica e Chimica Industriale, Università di Pisa, Via G. Moruzzi 13, 56124 Pisa, Italy.

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http://dx.doi.org/10.1016/j.bmc.2016.04.067DOI Listing
July 2016

Pathophysiological implications of mitochondrial oxidative stress mediated by mitochondriotropic agents and polyamines: the role of tyrosine phosphorylation.

Amino Acids 2015 May 20;47(5):869-83. Epub 2015 Mar 20.

Department of Biomedical Sciences, University of Padova, Viale U. Bassi 58B, 35131, Padua, Italy.

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http://dx.doi.org/10.1007/s00726-015-1964-7DOI Listing
May 2015

A novel enzyme with spermine oxidase properties in bovine liver mitochondria: identification and kinetic characterization.

Free Radic Biol Med 2015 Apr 13;81:88-99. Epub 2015 Jan 13.

Department of Molecular Medicine, University of Padova, Via G. Colombo 3, 35131 Padova, Italy; Consorzio Interuniversitario "Istituto Nazionale Biostrutture e Biosistemi," Viale delle medaglie d'Oro 305, 00136 Roma, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2015.01.001DOI Listing
April 2015

Nanoparticle strategies for cancer therapeutics: Nucleic acids, polyamines, bovine serum amine oxidase and iron oxide nanoparticles (Review).

Int J Oncol 2015 Jan 14;46(1):5-16. Epub 2014 Oct 14.

Department of Medicine, Rutgers Robert Wood Johnson Medical School, Rutgers the State University of New Jersey, New Brunswick, NJ 08901, USA.

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http://dx.doi.org/10.3892/ijo.2014.2706DOI Listing
January 2015

Polyamines and transglutaminases: biological, clinical, and biotechnological perspectives.

Authors:
Enzo Agostinelli

Amino Acids 2014 Mar 20;46(3):475-85. Epub 2014 Feb 20.

Istituto Pasteur-Fondazione Cenci Bolognetti, Department of Biochemical Sciences, SAPIENZA University of Rome, Piazzale Aldo Moro 5, 00185, Rome, Italy,

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http://dx.doi.org/10.1007/s00726-014-1688-0DOI Listing
March 2014

Novel polyamine analogues: from substrates towards potential inhibitors of monoamine oxidases.

Eur J Med Chem 2013 1;70:88-101. Epub 2013 Oct 1.

Department of Molecular Medicine, University of Padova, Via G. Colombo 3, 35131 Padova, Italy.

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http://dx.doi.org/10.1016/j.ejmech.2013.07.005DOI Listing
September 2014

Bidirectional fluxes of spermine across the mitochondrial membrane.

Amino Acids 2014 Mar 17;46(3):671-9. Epub 2013 Sep 17.

Department of Biomedical Sciences, University of Padua, Viale U. Bassi 58 B, 35131, Padua, Italy.

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http://dx.doi.org/10.1007/s00726-013-1591-0DOI Listing
March 2014

Activation of polyamine catabolic enzymes involved in diverse responses against epibrassinolide-induced apoptosis in LNCaP and DU145 prostate cancer cell lines.

Amino Acids 2014 Mar 21;46(3):553-64. Epub 2013 Aug 21.

Department of Molecular Biology and Genetics, Istanbul Kultur University, Atakoy Campus, Bakirkoy, 34156, Istanbul, Turkey.

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http://dx.doi.org/10.1007/s00726-013-1574-1DOI Listing
March 2014

Innovative approaches to the use of polyamines for DNA nanoparticle preparation for gene therapy.

Amino Acids 2014 Mar 17;46(3):499-509. Epub 2013 Jul 17.

Departments of Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, 08901, USA.

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http://dx.doi.org/10.1007/s00726-013-1549-2DOI Listing
March 2014

Hyaluronic acid nanohydrogels as a useful tool for BSAO immobilization in the treatment of melanoma cancer cells.

Macromol Biosci 2013 Sep 8;13(9):1185-94. Epub 2013 Jul 8.

Department of Drug Chemistry and Technologies, "Sapienza" University of Rome, P. le Aldo Moro 5, 00185, Rome, Italy.

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http://dx.doi.org/10.1002/mabi.201300114DOI Listing
September 2013

CDK inhibitors induce mitochondria-mediated apoptosis through the activation of polyamine catabolic pathway in LNCaP, DU145 and PC3 prostate cancer cells.

Curr Pharm Des 2014 ;20(2):180-8

Istanbul Kultur University, Faculty of Science and Letters, Department of Molecular Biology and Genetics, Istanbul, Turkey.

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http://dx.doi.org/10.2174/13816128113199990029DOI Listing
October 2014

Iron nanoparticles from animal blood for cellular imaging and targeted delivery for cancer treatment.

Biochim Biophys Acta 2013 Apr 10;1830(4):3005-10. Epub 2013 Jan 10.

St. Joseph's College of Engg, Sholinganallur, Chennai-600 119, India.

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http://dx.doi.org/10.1016/j.bbagen.2012.12.031DOI Listing
April 2013

Novel reversible monoamine oxidase A inhibitors: highly potent and selective 3-(1H-pyrrol-3-yl)-2-oxazolidinones.

J Med Chem 2011 Dec 7;54(23):8228-32. Epub 2011 Nov 7.

Dipartimento di Chimica e Tecnologie del Farmaco, Istituto Pasteur, Fondazione Cenci Bolognetti, Sapienza Università di Roma, Piazzale Aldo Moro 5, 00185 Roma, Italy.

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http://pubs.acs.org/doi/abs/10.1021/jm201011x
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http://dx.doi.org/10.1021/jm201011xDOI Listing
December 2011

Do mammalian amine oxidases and the mitochondrial polyamine transporter have similar protein structures?

Amino Acids 2012 Feb 2;42(2-3):725-31. Epub 2011 Aug 2.

Istituto Pasteur-Fondazione Cenci Bolognetti, Department of Biochemical Sciences, CNR, Institute Biology and Molecular Pathology, SAPIENZA University of Rome, Piazzale Aldo Moro 5, 00185, Rome, Italy.

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http://link.springer.com/10.1007/s00726-011-0988-x
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http://dx.doi.org/10.1007/s00726-011-0988-xDOI Listing
February 2012

Effect of peroxides on spermine transport in rat brain and liver mitochondria.

Amino Acids 2012 Feb 2;42(2-3):741-9. Epub 2011 Aug 2.

Department of Biological Chemistry, University of Padua, Viale G. Colombo 3, 35121, Padua, Italy.

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http://dx.doi.org/10.1007/s00726-011-0990-3DOI Listing
February 2012

Mitochondrial oxidative stress induced by Ca2+ and monoamines: different behaviour of liver and brain mitochondria in undergoing permeability transition.

Amino Acids 2012 Feb 30;42(2-3):751-9. Epub 2011 Jul 30.

Department of Biological Chemistry, University of Padua, Viale G. Colombo 3, 35131, Padua, Italy.

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http://dx.doi.org/10.1007/s00726-011-0991-2DOI Listing
February 2012

Further characterization of agmatine binding to mitochondrial membranes: involvement of imidazoline I2 receptor.

Amino Acids 2012 Feb 29;42(2-3):761-8. Epub 2011 Jul 29.

Department of Biological Chemistry, University of Padua, Viale G. Colombo 3, 35121, Padua, Italy.

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http://dx.doi.org/10.1007/s00726-011-0992-1DOI Listing
February 2012

Platinum(II) chloride indenyl complexes: electrochemical and biological evaluation.

J Biol Inorg Chem 2011 Jun 29;16(5):695-713. Epub 2011 Mar 29.

Department of Pharmaceutical Sciences, University of Padova, Padua, Italy.

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http://link.springer.com/10.1007/s00775-011-0771-1
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http://dx.doi.org/10.1007/s00775-011-0771-1DOI Listing
June 2011

A rapid and robust assay for the determination of the amino acid hypusine as a possible biomarker for a high-throughput screening of antimalarials and for the diagnosis and therapy of different diseases.

Amino Acids 2012 May 1;42(5):1651-9. Epub 2011 Mar 1.

Institut für Technische Chemie und Pharmazeutische Chemie, University of Applied Sciences, Cologne, Betzdorfer Str.2, 50679, Cologne, Germany.

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http://dx.doi.org/10.1007/s00726-011-0859-5DOI Listing
May 2012

Preliminary kinetic characterization of a copper amine oxidase from rat liver mitochondria matrix.

Amino Acids 2011 Feb 5;40(2):713-20. Epub 2010 Aug 5.

Department of Physical Chemistry, University of Venice Ca' Foscari, Dorsoduro 2137, 30123, Venice, Italy.

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http://dx.doi.org/10.1007/s00726-010-0708-yDOI Listing
February 2011

Polyamines in biological systems.

Authors:
Enzo Agostinelli

Amino Acids 2010 Feb;38(2):351-2

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http://dx.doi.org/10.1007/s00726-009-0395-8DOI Listing
February 2010

Cytotoxicity of spermine oxidation products to multidrug resistant melanoma M14 ADR2 cells: sensitization by the MDL 72527 lysosomotropic compound.

Int J Oncol 2009 Sep;35(3):485-98

Department of Biochemical Sciences A. Rossi Fanelli, Sapienza University of Rome, Piazzale Aldo Moro 5, Rome, Italy.

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http://dx.doi.org/10.3892/ijo_00000360DOI Listing
September 2009

Synthesis, structure-activity relationships and molecular modeling studies of new indole inhibitors of monoamine oxidases A and B.

Bioorg Med Chem 2008 Nov 2;16(22):9729-40. Epub 2008 Oct 2.

Istituto Pasteur - Fondazione Cenci Bolognetti, Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza Università di Roma, Piazzale Aldo Moro 5, I-00185 Roma, Italy.

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http://linkinghub.elsevier.com/retrieve/pii/S096808960800937
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http://dx.doi.org/10.1016/j.bmc.2008.09.072DOI Listing
November 2008

Src-Tyrosine kinases are major agents in mitochondrial tyrosine phosphorylation.

J Cell Biochem 2008 Jun;104(3):840-9

Dipartimento di Chimica Biologica, Universita' di Padova, Istituto di Neuroscienze del C.N.R., Via G. Colombo 3, 35121 Padova, Italy.

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http://dx.doi.org/10.1002/jcb.21670DOI Listing
June 2008

Mechanism of cell death induced by spermine and amine oxidase in mouse melanoma cells.

Int J Oncol 2008 Jan;32(1):79-88

Département des Sciences Biologiques, Université du Québec à Montréal, Montréal, Québec, H3C 3P8, Canada.

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January 2008

Lysosomotropic compounds and spermine enzymatic oxidation products in cancer therapy (review).

Int J Oncol 2007 Sep;31(3):473-84

Department of Biochemical Sciences A Rossi Fanelli, University of Rome La Sapienza, Rome, Italy.

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September 2007

New pyrrole inhibitors of monoamine oxidase: synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity.

J Med Chem 2007 Mar 26;50(5):922-31. Epub 2007 Jan 26.

Dipartimento di Studi Farmaceutici, Università di Roma La Sapienza, Piazzale Aldo Moro 5, I-00185 Roma, Italy.

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http://dx.doi.org/10.1021/jm060882yDOI Listing
March 2007

Sensitization of human colon adenocarcinoma cells (LoVo) to reactive oxygen species by a lysosomotropic compound.

Int J Oncol 2006 Oct;29(4):947-55

Department of Biochemical Sciences 'A. Rossi Fanelli', University of Rome 'La Sapienza', I-00185 Rome, Italy.

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October 2006

Toxicity of enzymatic oxidation products of spermine to human melanoma cells (M14): sensitization by heat and MDL 72527.

Biochim Biophys Acta 2006 Oct 31;1763(10):1040-50. Epub 2006 Jul 31.

Department of Biochemical Sciences A. Rossi Fanelli, University of Rome La Sapienza and CNR, Biology and Molecular Pathology Institutes, Piazzale Aldo Moro 5, 00185 Rome, Italy.

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http://dx.doi.org/10.1016/j.bbamcr.2006.07.014DOI Listing
October 2006

Hyperthermia enhances cytotoxicity of amine oxidase and spermine on drug-resistant LoVo colon adenocarcinoma cells.

Int J Oncol 2006 Jun;28(6):1543-53

Department of Biochemical Sciences 'A. Rossi Fanelli', University of Rome 'La Sapienza', I-00185 Rome, Italy.

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June 2006

Interaction of bovine serum amine oxidase with the polyamine oxidase inactivator MDL 72527.

Biochem Biophys Res Commun 2006 Feb 20;340(3):840-4. Epub 2005 Dec 20.

Department of Biochemical Sciences A. Rossi Fanelli, University of Rome La Sapienza and CNR, Biology Institute, Rome, Italy.

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http://dx.doi.org/10.1016/j.bbrc.2005.12.066DOI Listing
February 2006

Design, synthesis, and biological activities of pyrrolylethanoneamine derivatives, a novel class of monoamine oxidases inhibitors.

J Med Chem 2005 Jun;48(13):4220-3

Istituto Pasteur-Fondazione Cenci Bolognetti, Dipartimento di Studi Farmaceutici (Dip. 63), Università di Roma La Sapienza, Piazzale A. Moro 5, I-00185 Roma, Italy.

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http://dx.doi.org/10.1021/jm050172cDOI Listing
June 2005

Anti-tumoral effect of native and immobilized bovine serum amine oxidase in a mouse melanoma model.

Biochem Pharmacol 2005 Jun;69(12):1693-704

Département de chimie et biochimie, TOXEN, Université du Québec à Montréal, Case Postale 8888, Succursale Centre Ville, Montréal, Que., Canada H3C 3P8.

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http://dx.doi.org/10.1016/j.bcp.2005.02.025DOI Listing
June 2005

Simple, potent, and selective pyrrole inhibitors of monoamine oxidase types A and B.

J Med Chem 2003 Mar;46(6):917-20

Dipartimento di Studi Farmaceutici, Università degli Studi di Roma La Sapienza, P.le Aldo Moro, 5, I-00185 Roma, Italy.

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http://dx.doi.org/10.1021/jm0256124DOI Listing
March 2003

Noradrenergic and cholinergic innervation of the bone marrow.

Int J Mol Med 2002 Jul;10(1):77-80

Department of Pharmacology of Natural Molecules and General Physiology, University of Rome La Sapienza, Italy.

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July 2002