Publications by authors named "Emma Bolderson"

33Publications

SASH1 is a prognostic indicator and potential therapeutic target in non-small cell lung cancer.

Sci Rep 2020 10 29;10(1):18605. Epub 2020 Oct 29.

Cancer and Ageing Research Program, Centre for Genomics and Personalised Health at the Translational Research Institute (TRI), Queensland University of Technology, 37 Kent Street Woolloongabba, Brisbane, 4102, Australia.

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http://dx.doi.org/10.1038/s41598-020-75625-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7596716PMC
October 2020

PARP Inhibitors: Clinical Relevance, Mechanisms of Action and Tumor Resistance.

Front Cell Dev Biol 2020 9;8:564601. Epub 2020 Sep 9.

Cancer & Ageing Research Program, School of Biomedical Sciences, Institute of Health and Biomedical Innovation, Translational Research Institute, Queensland University of Technology, Brisbane, QLD, Australia.

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http://dx.doi.org/10.3389/fcell.2020.564601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7509090PMC
September 2020

The Therapeutic Potential of DNA Damage Repair Pathways and Genomic Stability in Lung Cancer.

Front Oncol 2020 28;10:1256. Epub 2020 Jul 28.

Cancer & Ageing Research Program, School of Biomedical Sciences, Institute of Health and Biomedical Innovation at the Translational Research Institute (TRI), Queensland University of Technology (QUT), Brisbane, QLD, Australia.

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http://dx.doi.org/10.3389/fonc.2020.01256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7399071PMC
July 2020

Barrier-to-autointegration factor 1 (Banf1) regulates poly [ADP-ribose] polymerase 1 (PARP1) activity following oxidative DNA damage.

Nat Commun 2019 12 3;10(1):5501. Epub 2019 Dec 3.

Cancer & Ageing Research Program, Institute of Health and Biomedical Innovation at the Translational Research Institute (TRI), Queensland University of Technology (QUT), Brisbane, Queensland, Australia.

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http://dx.doi.org/10.1038/s41467-019-13167-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6890647PMC
December 2019

Human single-stranded DNA binding protein 1 (hSSB1, OBFC2B), a critical component of the DNA damage response.

Semin Cell Dev Biol 2019 02 28;86:121-128. Epub 2018 Mar 28.

Genome Stability Laboratory, Cancer and Ageing Research Program, Institute of Health and Biomedical Innovation, Translational Research Institute, Queensland University of Technology, Woolloongabba, Queensland 4102, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.semcdb.2018.03.014DOI Listing
February 2019

hSSB1 associates with and promotes stability of the BLM helicase.

BMC Mol Biol 2017 05 15;18(1):13. Epub 2017 May 15.

School of Biomedical Research, Institute of Health and Biomedical Innovation at the Translational Research Institute, Queensland University of Technology, 37 Kent Street, Woolloongabba, QLD, 4102, Australia.

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http://dx.doi.org/10.1186/s12867-017-0090-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433028PMC
May 2017

hSSB1 phosphorylation is dynamically regulated by DNA-PK and PPP-family protein phosphatases.

DNA Repair (Amst) 2017 06 6;54:30-39. Epub 2017 Apr 6.

School of Biomedical Research, Institute of Health and Biomedical Innovation at the Translational Research Institute, Queensland University of Technology, 37 Kent Street, Woolloongabba 4102, QLD, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2017.03.006DOI Listing
June 2017

Activation and cleavage of SASH1 by caspase-3 mediates an apoptotic response.

Cell Death Dis 2016 11 10;7(11):e2469. Epub 2016 Nov 10.

Cancer and Ageing Program, Institute of Health and Biomedical Innovation at the Translational Research Institute (TRI), Queensland University of Technology (QUT) and Princess Alexandra Hospital, Level 6, Translational Research Institute, Brisbane, QLD, Australia.

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http://dx.doi.org/10.1038/cddis.2016.364DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5260870PMC
November 2016

SASH1 mediates sensitivity of breast cancer cells to chloropyramine and is associated with prognosis in breast cancer.

Oncotarget 2016 11;7(45):72807-72818

Cancer and Ageing Research Program, Institute of Health and Biomedical Innovation at the Translational Research Institute (TRI), Queensland University of Technology, Brisbane, Australia.

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http://dx.doi.org/10.18632/oncotarget.12020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341945PMC
November 2016

Nucleophosmin: from structure and function to disease development.

BMC Mol Biol 2016 08 24;17(1):19. Epub 2016 Aug 24.

School of Biomedical Research, Institute of Health and Biomedical Innovation at the Translational Research Institute, Queensland University of Technology, Brisbane, QLD, Australia.

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http://dx.doi.org/10.1186/s12867-016-0073-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995807PMC
August 2016

hSSB1 (NABP2/OBFC2B) is regulated by oxidative stress.

Sci Rep 2016 06 8;6:27446. Epub 2016 Jun 8.

School of Biomedical Research, Institute of Health and Biomedical Innovation at the Translational Research Institute, Queensland University of Technology, Woolloongabba, QLD4 102, Australia.

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http://dx.doi.org/10.1038/srep27446DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4897654PMC
June 2016

hSSB1 (NABP2/ OBFC2B) is required for the repair of 8-oxo-guanine by the hOGG1-mediated base excision repair pathway.

Nucleic Acids Res 2015 Oct 10;43(18):8817-29. Epub 2015 Aug 10.

School of Biomedical Research, Institute of Health and Biomedical Innovation at the Translational Research Institute, Queensland University of Technology, Woolloongabba, QLD 4102, Australia

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http://dx.doi.org/10.1093/nar/gkv790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605301PMC
October 2015

Néstor-Guillermo Progeria Syndrome: a biochemical insight into Barrier-to-Autointegration Factor 1, alanine 12 threonine mutation.

BMC Mol Biol 2014 Dec 12;15:27. Epub 2014 Dec 12.

School of Biomedical Science, Institute of Health and Biomedical Innovation at the Translational Research Institute, Queensland University of Technology, Brisbane, QLD, Australia.

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http://dx.doi.org/10.1186/s12867-014-0027-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266902PMC
December 2014

Rad51 supports triple negative breast cancer metastasis.

Oncotarget 2014 May;5(10):3261-72

QIMR Berghofer Medical Research Institute, Signal Transduction Laboratory, Herston Rd, Herston QLD 4006, Australia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102808PMC
http://dx.doi.org/10.18632/oncotarget.1923DOI Listing
May 2014

Chemotherapeutic compounds targeting the DNA double-strand break repair pathways: the good, the bad, and the promising.

Front Oncol 2014 22;4:86. Epub 2014 Apr 22.

Cancer and Ageing Research Program, Institute of Health and Biomedical Innovation, Queensland University of Technology , Brisbane, QLD , Australia.

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http://dx.doi.org/10.3389/fonc.2014.00086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001069PMC
June 2014

Human single-stranded DNA binding protein 1 (hSSB1/NABP2) is required for the stability and repair of stalled replication forks.

Nucleic Acids Res 2014 Jun 20;42(10):6326-36. Epub 2014 Apr 20.

Genome Stability Laboratory, Cancer and Ageing Research Program, Institute of Health and Biomedical Innovation, Translational Research Institute, Queensland University of Technology, Woolloongabba, Queensland, 4102, Australia

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http://dx.doi.org/10.1093/nar/gku276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041449PMC
June 2014

Human single-stranded DNA binding proteins are essential for maintaining genomic stability.

BMC Mol Biol 2013 Apr 1;14. Epub 2013 Apr 1.

Genome Stability Laboratory, Cancer and Ageing Research Program, Institute of Health and Biomedical Innovation, Translational Research Institute, Queensland University of Technology, Woolloongabba, Queensland, 4102, Australia.

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http://dx.doi.org/10.1186/1471-2199-14-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3626794PMC
April 2013

Exo1 plays a major role in DNA end resection in humans and influences double-strand break repair and damage signaling decisions.

DNA Repair (Amst) 2012 Apr 11;11(4):441-8. Epub 2012 Feb 11.

Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, USA.

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http://dx.doi.org/10.1016/j.dnarep.2012.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319278PMC
April 2012

Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks.

Nucleic Acids Res 2010 Apr 17;38(6):1821-31. Epub 2009 Dec 17.

Signal Transduction Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia.

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http://dx.doi.org/10.1093/nar/gkp1164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2847229PMC
April 2010

Recent advances in cancer therapy targeting proteins involved in DNA double-strand break repair.

Clin Cancer Res 2009 Oct 6;15(20):6314-20. Epub 2009 Oct 6.

Signal Transduction Laboratory, Queensland Institute of Medical Research, 300 Herston Road, Herston, Brisbane, QLD 4006, Australia.

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http://dx.doi.org/10.1158/1078-0432.CCR-09-0096DOI Listing
October 2009

SECIS-binding protein 2 promotes cell survival by protecting against oxidative stress.

Antioxid Redox Signal 2010 Apr;12(7):797-808

Signal Transduction Laboratory, Queensland Institute of Medical Research, Herston, Queensland, Australia.

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http://dx.doi.org/10.1089/ars.2009.2913DOI Listing
April 2010

INTS3 controls the hSSB1-mediated DNA damage response.

J Cell Biol 2009 Oct 28;187(1):25-32. Epub 2009 Sep 28.

Howard Hughes Medical Institute, New York University Cancer Institute, New York University School of Medicine, New York, NY 10016, USA.

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http://dx.doi.org/10.1083/jcb.200907026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2762097PMC
October 2009

HSSB1 and hSSB2 form similar multiprotein complexes that participate in DNA damage response.

J Biol Chem 2009 Aug 14;284(35):23525-31. Epub 2009 Jul 14.

Laboratory of Genetics, NIA, National Institutes of Health, NIH Biomedical Research Center, Baltimore, Maryland 21224, USA.

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http://dx.doi.org/10.1074/jbc.C109.039586DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2749126PMC
August 2009

Multiple human single-stranded DNA binding proteins function in genome maintenance: structural, biochemical and functional analysis.

Crit Rev Biochem Mol Biol 2009 Jun;44(2-3):98-116

Cancer and Cell Biology Division, The Queensland Institute of Medical Research, 300 Herston Road, Herston, QLD 4006, Australia.

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http://dx.doi.org/10.1080/10409230902849180DOI Listing
June 2009

Involvement of Exo1b in DNA damage-induced apoptosis.

Nucleic Acids Res 2009 Jun 1;37(10):3452-63. Epub 2009 Apr 1.

Signal Transduction Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland 4006, Australia.

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http://dx.doi.org/10.1093/nar/gkp194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2691832PMC
June 2009

ATM is required for the cellular response to thymidine induced replication fork stress.

Hum Mol Genet 2004 Dec 30;13(23):2937-45. Epub 2004 Sep 30.

Institute for Cancer Studies, School of Medicine, University of Sheffield, UK.

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http://dx.doi.org/10.1093/hmg/ddh316DOI Listing
December 2004

A tumour-derived mutant allele of XRCC2 preferentially suppresses homologous recombination at DNA replication forks.

Hum Mol Genet 2004 Jan 25;13(2):203-12. Epub 2003 Nov 25.

Institute for Cancer Studies, University of Sheffield, School of Medicine, Sheffield, UK.

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http://dx.doi.org/10.1093/hmg/ddh022DOI Listing
January 2004