Edward Wojcik

Edward Wojcik

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Edward Wojcik

Edward Wojcik

Publications by authors named "Edward Wojcik"

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15Publications

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Small molecule allosteric uncoupling of microtubule depolymerase activity from motility in human Kinesin-5 during mitotic spindle assembly.

Sci Rep 2019 12 27;9(1):19900. Epub 2019 Dec 27.

Department of Biochemistry and Molecular Biology, LSU School of Medicine & Health Sciences Center, 1901 Perdido Street, New Orleans, LA, 70112, USA.

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http://dx.doi.org/10.1038/s41598-019-56173-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934681PMC
December 2019

Disruption of the Putative Ribosome-Binding Motif of a Scaffold Protein Impairs Cytochrome Oxidase Subunit Expression in .

mSphere 2019 03 6;4(2). Epub 2019 Mar 6.

Department of Microbiology, Immunology and Parasitology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA

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http://dx.doi.org/10.1128/mSphere.00644-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403457PMC
March 2019

Characterization of kinesin switch I mutations that cause hereditary spastic paraplegia.

PLoS One 2017 5;12(7):e0180353. Epub 2017 Jul 5.

Department of Biology, Xavier University of Louisiana, New Orleans, Louisiana, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0180353PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5498027PMC
October 2017

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.

Authors:
Wesley C Van Voorhis John H Adams Roberto Adelfio Vida Ahyong Myles H Akabas Pietro Alano Aintzane Alday Yesmalie Alemán Resto Aishah Alsibaee Ainhoa Alzualde Katherine T Andrews Simon V Avery Vicky M Avery Lawrence Ayong Mark Baker Stephen Baker Choukri Ben Mamoun Sangeeta Bhatia Quentin Bickle Lotfi Bounaadja Tana Bowling Jürgen Bosch Lauren E Boucher Fabrice F Boyom Jose Brea Marian Brennan Audrey Burton Conor R Caffrey Grazia Camarda Manuela Carrasquilla Dee Carter Maria Belen Cassera Ken Chih-Chien Cheng Worathad Chindaudomsate Anthony Chubb Beatrice L Colon Daisy D Colón-López Yolanda Corbett Gregory J Crowther Noemi Cowan Sarah D'Alessandro Na Le Dang Michael Delves Joseph L DeRisi Alan Y Du Sandra Duffy Shimaa Abd El-Salam El-Sayed Michael T Ferdig José A Fernández Robledo David A Fidock Isabelle Florent Patrick V T Fokou Ani Galstian Francisco Javier Gamo Suzanne Gokool Ben Gold Todd Golub Gregory M Goldgof Rajarshi Guha W Armand Guiguemde Nil Gural R Kiplin Guy Michael A E Hansen Kirsten K Hanson Andrew Hemphill Rob Hooft van Huijsduijnen Takaaki Horii Paul Horrocks Tyler B Hughes Christopher Huston Ikuo Igarashi Katrin Ingram-Sieber Maurice A Itoe Ajit Jadhav Amornrat Naranuntarat Jensen Laran T Jensen Rays H Y Jiang Annette Kaiser Jennifer Keiser Thomas Ketas Sebastien Kicka Sunyoung Kim Kiaran Kirk Vidya P Kumar Dennis E Kyle Maria Jose Lafuente Scott Landfear Nathan Lee Sukjun Lee Adele M Lehane Fengwu Li David Little Liqiong Liu Manuel Llinás Maria I Loza Aristea Lubar Leonardo Lucantoni Isabelle Lucet Louis Maes Dalu Mancama Nuha R Mansour Sandra March Sheena McGowan Iset Medina Vera Stephan Meister Luke Mercer Jordi Mestres Alvine N Mfopa Raj N Misra Seunghyun Moon John P Moore Francielly Morais Rodrigues da Costa Joachim Müller Arantza Muriana Stephen Nakazawa Hewitt Bakela Nare Carl Nathan Nathalie Narraidoo Sujeevi Nawaratna Kayode K Ojo Diana Ortiz Gordana Panic George Papadatos Silvia Parapini Kailash Patra Ngoc Pham Sarah Prats David M Plouffe Sally-Ann Poulsen Anupam Pradhan Celia Quevedo Ronald J Quinn Christopher A Rice Mohamed Abdo Rizk Andrea Ruecker Robert St Onge Rafaela Salgado Ferreira Jasmeet Samra Natalie G Robinett Ulrich Schlecht Marjorie Schmitt Filipe Silva Villela Francesco Silvestrini Robert Sinden Dennis A Smith Thierry Soldati Andreas Spitzmüller Serge Maximilian Stamm David J Sullivan William Sullivan Sundari Suresh Brian M Suzuki Yo Suzuki S Joshua Swamidass Donatella Taramelli Lauve R Y Tchokouaha Anjo Theron David Thomas Kathryn F Tonissen Simon Townson Abhai K Tripathi Valentin Trofimov Kenneth O Udenze Imran Ullah Cindy Vallieres Edgar Vigil Joseph M Vinetz Phat Voong Vinh Hoan Vu Nao-Aki Watanabe Kate Weatherby Pamela M White Andrew F Wilks Elizabeth A Winzeler Edward Wojcik Melanie Wree Wesley Wu Naoaki Yokoyama Paul H A Zollo Nada Abla Benjamin Blasco Jeremy Burrows Benoît Laleu Didier Leroy Thomas Spangenberg Timothy Wells Paul A Willis

PLoS Pathog 2016 07 28;12(7):e1005763. Epub 2016 Jul 28.

Medicines for Malaria Venture, Geneva, Switzerland.

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http://dx.doi.org/10.1371/journal.ppat.1005763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965013PMC
July 2016

Small molecule screen for candidate antimalarials targeting Plasmodium Kinesin-5.

J Biol Chem 2014 Jun 15;289(23):16601-14. Epub 2014 Apr 15.

From the Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112

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http://dx.doi.org/10.1074/jbc.M114.551408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047425PMC
June 2014

Kinesin-5: cross-bridging mechanism to targeted clinical therapy.

Gene 2013 Dec 14;531(2):133-49. Epub 2013 Aug 14.

Department of Biochemistry and Molecular Biology, LSU School of Medicine & Health Sciences Center, New Orleans, LA 70112, USA. Electronic address:

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http://dx.doi.org/10.1016/j.gene.2013.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3801170PMC
December 2013

Loop 5-directed compounds inhibit chimeric kinesin-5 motors: implications for conserved allosteric mechanisms.

J Biol Chem 2011 Feb 2;286(8):6201-10. Epub 2010 Dec 2.

Department of Biochemistry and Molecular Biology, LSU Health Sciences Center, New Orleans, Louisiana 70112, USA.

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http://dx.doi.org/10.1074/jbc.M110.154989DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057856PMC
February 2011

Allosteric drug discrimination is coupled to mechanochemical changes in the kinesin-5 motor core.

J Biol Chem 2010 Jun 18;285(24):18650-61. Epub 2010 Mar 18.

Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA.

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http://dx.doi.org/10.1074/jbc.M109.092072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2881790PMC
June 2010

ATP hydrolysis in Eg5 kinesin involves a catalytic two-water mechanism.

J Biol Chem 2010 Feb 15;285(8):5859-67. Epub 2009 Dec 15.

Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA.

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http://dx.doi.org/10.1074/jbc.M109.071233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2820811PMC
February 2010

NSC 622124 inhibits human Eg5 and other kinesins via interaction with the conserved microtubule-binding site.

Biochemistry 2009 Mar;48(8):1754-62

Department of Biological Sciences, 2119 Derring Hall, Virginia Tech, Blacksburg, Virginia 24061-0406, USA.

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http://dx.doi.org/10.1021/bi801291qDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3244877PMC
March 2009

The Drosophila modigliani (moi) gene encodes a HOAP-interacting protein required for telomere protection.

Proc Natl Acad Sci U S A 2009 Feb 30;106(7):2271-6. Epub 2009 Jan 30.

Istituto di Biologia e Patologia Molecolari del CNR and Dipartimento di Genetica e Biologia Molecolare, Sapienza, Università di Roma, 00185 Rome, Italy.

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http://dx.doi.org/10.1073/pnas.0812702106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2650146PMC
February 2009

A mitotic role for GSK-3beta kinase in Drosophila.

Authors:
Edward J Wojcik

Cell Cycle 2008 Dec 13;7(23):3699-708. Epub 2008 Dec 13.

Department of Biochemistry and Molecular Biology, LSU School of Medicine, New Orleans, Louisiana 70112, USA.

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http://dx.doi.org/10.4161/cc.7.23.7179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713227PMC
December 2008

Disparity in allosteric interactions of monastrol with Eg5 in the presence of ADP and ATP: a difference FT-IR investigation.

Biochemistry 2004 Aug;43(31):9939-49

Department of Biology, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA.

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http://dx.doi.org/10.1021/bi048982yDOI Listing
August 2004

In vivo dynamics of the rough deal checkpoint protein during Drosophila mitosis.

Curr Biol 2004 Jan;14(1):56-61

Centre de National de Récherche Scientifique, Centre de Génétique Moléculaire, Avenue de la Terasse, 91198, Gif-sur-Yvette, France.

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http://dx.doi.org/10.1016/j.cub.2003.12.025DOI Listing
January 2004