Eberhard Schleyer

A phase I study of a dual PI3-kinase/mTOR inhibitor BEZ235 in adult patients with relapsed or refractory acute leukemia.

Authors:

Fabian Lang Lydia Wunderle Susanne Badura Eberhard Schleyer Monika Brüggemann Hubert Serve Susanne Schnittger Nicola Gökbuget Heike Pfeifer Sebastian Wagner Kevin Ashelford Gesine Bug Oliver G Ottmann

BMC Pharmacol Toxicol 2020 09 29;21(1):70. Epub 2020 Sep 29.

School of Medicine, Cardiff University, Cardiff, Wales, UK.

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September 2020

Pharmacology and pharmacokinetics of imatinib in pediatric patients.

Authors:

Meinolf Suttorp Martin Bornhäuser Markus Metzler Frédéric Millot Eberhard Schleyer

Expert Rev Clin Pharmacol 2018 Mar 6;11(3):219-231. Epub 2017 Nov 6.

b I. Medical Clinic , University Hospital 'Carl Gustav Carus' , Dresden , Germany.

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March 2018

Efficacy and pharmacologic data of second-generation tyrosine kinase inhibitor nilotinib in BCR-ABL-positive leukemia patients with central nervous system relapse after allogeneic stem cell transplantation.

Authors:

Mark Reinwald Eberhard Schleyer Philipp Kiewe Igor Wolfgang Blau Thomas Burmeister Stefan Pursche Martin Neumann Michael Notter Eckhard Thiel Wolf-Karsten Hofmann Hans-Jochem Kolb Stefan Burdach Hans-Ulrich Bender

Biomed Res Int 2014 15;2014:637059. Epub 2014 Jun 15.

Division of Pediatric Hematology/Oncology, Department of Pediatrics, Technische Universität München, Kölner Platz 1, 80804 München, Germany.

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March 2015

Eltrombopag fails to improve severe thrombocytopenia in late-stage dyskeratosis congenita and diamond-blackfan-anaemia.

Authors:

Karolin Trautmann Christiane Jakob Ulrich von Grünhagen Eberhard Schleyer Tim H Brümmendorf Gabriele Siegert Gerhard Ehninger Uwe Platzbecker

Thromb Haemost 2012 Aug 28;108(2):397-8. Epub 2012 Jun 28.

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August 2012

Survey and analysis of the efficacy and prescription pattern of sorafenib in patients with acute myeloid leukemia.

Authors:

Christoph Röllig Christian Brandts Shabnam Shaid Marcus Hentrich Alwin Krämer Christian Junghanß Eberhard Schleyer Carsten Müller-Tidow Wolfgang E Berdel Barbara Ritter Karl-Heinz Pflüger Michael Kramer Martina Haibach Gerhard Ehninger Hubert Serve Stefan W Krause

Leuk Lymphoma 2012 Jun 7;53(6):1062-7. Epub 2011 Dec 7.

Medizinische Klinik und Poliklinik I, Universitätsklinikum, Dresden, Germany.

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June 2012

Imatinib mesylate for palliative second-line treatment of advanced biliary tract cancer: a bicentric phase II study.

Authors:

Annekathrin Roth Eberhard Schleyer Konrad Schoppmeyer Regine Kluge Christian Wittekind Joachim Mössner Marcus Wiedmann

Onkologie 2011 22;34(8-9):469-70. Epub 2011 Aug 22.

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March 2012

Imatinib in combination with hydroxyurea versus hydroxyurea alone as oral therapy in patients with progressive pretreated glioblastoma resistant to standard dose temozolomide.

J Neurooncol 2010 Feb 18;96(3):393-402. Epub 2009 Aug 18.

Zentrum für Neuro-Onkologie am Arztehaus Velen, Ignatiusstrasse 8, 46342, Velen, Germany.

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February 2010

Imatinib in breast milk.

Authors:

Roland Kronenberger Eberhard Schleyer Martin Bornhäuser Gerhard Ehninger Norbert Gattermann Sabine Blum

Ann Hematol 2009 Dec 22;88(12):1265-6. Epub 2009 May 22.

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December 2009

Influence of enzyme-inducing antiepileptic drugs on trough level of imatinib in glioblastoma patients.

Authors:

Stefan Pursche Eberhard Schleyer Malte von Bonin Gerhard Ehninger Samir Mustafa Said Roland Prondzinsky Thomas Illmer Yanfeng Wang Christian Hosius Zariana Nikolova Martin Bornhäuser Gregor Dresemann

Curr Clin Pharmacol 2008 Sep;3(3):198-203

Carl Gustav Carus University, Internal Medicine I, Division of Hematology and Oncology, Dresden, Germany.

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September 2008

Pharmacokinetic comparison of oral and intravenous etoposide in patients treated with the CHOEP-regimen for malignant lymphomas.

Authors:

Frank P Kroschinsky Kai Friedrichsen Juliane Mueller Stefan Pursche Mathias Haenel Roland Prondzinsky Gerhard Ehninger Eberhard Schleyer

Cancer Chemother Pharmacol 2008 Apr 20;61(5):785-90. Epub 2007 Jun 20.

Medical Department I, Dresden University Hospital, Fetscherstrasse 74, 01307 Dresden, Germany.

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April 2008

A highly sensitive method for the detection of PKC412 (CGP41251) and its metabolites by high-performance liquid chromatography.

Authors:

Thomas Illmer Hans-M Thiede Christian Thiede Martin Bornhäuser Markus Schaich Eberhard Schleyer Gerhard Ehninger

J Pharmacol Toxicol Methods 2007 Jul-Aug;56(1):23-7. Epub 2007 Feb 23.

Medical Clinic and Policlinic I, Technical University Dresden, Germany.

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August 2007

Imatinib mesylate for targeting the platelet-derived growth factor beta receptor in combination with fluorouracil and leucovorin in patients with refractory pancreatic, bile duct, colorectal, or gastric cancer--a dose-escalation Phase I trial.

Authors:

Salah-Eddin Al-Batran Akin Atmaca Eberhard Schleyer Claudia Pauligk Christian Hosius Gerhard Ehninger Elke Jäger

Cancer 2007 May;109(9):1897-904

Department of Hematology and Oncology, Krankenhaus Nordwest, Frankfurt am Main, Germany.

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May 2007

Elimination of imatinib mesylate and its metabolite N-desmethyl-imatinib.

Authors:

Martin Bornhäuser Stefan Pursche Malte Bonin Jens Freiberg-Richter Andreas Jenke Thomas Illmer Gerhard Ehninger Eberhard Schleyer

J Clin Oncol 2005 Jun;23(16):3855-6; author reply 3857-8

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June 2005

Improved assay for determination of busulfan by liquid chromatography using postcolumn photolysis.

Authors:

Andreas Jenke Ulf Renner Ulrich S Schuler Sylvia Wauer Traugott Leopold Eberhard Schleyer Gerhard Ehninger

J Chromatogr B Analyt Technol Biomed Life Sci 2004 Jun;805(1):147-53

Department of Internal Medicine I, Technical University of Dresden, Fetscherstrasse 74, 01307 Dresden, Germany.

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June 2004

CNS blast crisis of chronic myelogenous leukemia in a patient with a major cytogenetic response in bone marrow associated with low levels of imatinib mesylate and its N-desmethylated metabolite in cerebral spinal fluid.

Authors:

Martin Bornhauser Andreas Jenke Jens Freiberg-Richter Jörgen Radke Ulrich S Schuler Brigitte Mohr Gerhard Ehninger Eberhard Schleyer

Ann Hematol 2004 Jun 12;83(6):401-2. Epub 2003 Dec 12.

Med. Klinik und Poliklinik I, Universitätsklinikum Carl Gustav Carus, Fetscherstrasse 74, 01307 Dresden, Germany.

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June 2004

Pharmacokinetics and cellular uptake of imatinib and its main metabolite CGP74588.

Authors:

Philipp le Coutre Karl-Anton Kreuzer Stefan Pursche Malte v Bonin Traugott Leopold Gökben Baskaynak Bernd Dörken Gerhard Ehninger Oliver Ottmann Andreas Jenke Martin Bornhäuser Eberhard Schleyer

Cancer Chemother Pharmacol 2004 Apr 5;53(4):313-23. Epub 2003 Dec 5.

Medizinische Klinik für Hämatologie und Onkologie, Campus Virchow, Charité, Humboldt Universität Berlin, Germany.

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April 2004

Risk and prognosis of central nervous system leukemia in patients with Philadelphia chromosome-positive acute leukemias treated with imatinib mesylate.

Authors:

Heike Pfeifer Barbara Wassmann Wolf-Karsten Hofmann Martina Komor Urban Scheuring Patrick Brück Anja Binckebanck Eberhard Schleyer Nicola Gökbuget Thomas Wolff Michael Lübbert Lothar Leimer Harald Gschaidmeier Dieter Hoelzer Oliver G Ottmann

Clin Cancer Res 2003 Oct;9(13):4674-81

Department of Hematology, Johann Wolfgang Goethe-Universität, 60590 Frankfurt, Germany.

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October 2003

Increased myelotoxicity of idarubicin: is there a pharmacological basis? Results of a pharmacokinetic and an in vitro cytotoxicity study.

Authors:

Frank Kroschinsky Eberhard Schleyer Ulf Renner Claudia Schimming Christoph Schimmelpfennig Martin Bornhäuser Thomas Illmer Lorenz Trümper Gerhard Ehninger Markus Schaich

Cancer Chemother Pharmacol 2004 Jan 3;53(1):61-7. Epub 2003 Sep 3.

1st Medical Department, Carl Gustav Carus University Hospital, Fetscherstrasse 74, 01307, Dresden, Germany.

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January 2004

Conditioning with fludarabine and targeted busulfan for transplantation of allogeneic hematopoietic stem cells.

Authors:

Martin Bornhauser Barry Storer John T Slattery Frederick R Appelbaum H Joachim Deeg John Hansen Paul J Martin George B McDonald W Garrett Nichols Jerald Radich Ann Woolfrey Andreas Jenke Eberhard Schleyer Christian Thiede Gerhard Ehninger Claudio Anasetti

Blood 2003 Aug 3;102(3):820-6. Epub 2003 Apr 3.

Medizinische Klinik und Poliklinik I, Universitätsklinikum Carl Gustav Carus, Fetscherstrasse 74, 01307 Dresden, Germany.

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August 2003

Pharmacokinetics of gemcitabine in a patient with end-stage renal disease: effective clearance of its main metabolite by standard hemodialysis treatment.

Authors:

Alexander Kiani Claus-Henning Köhne Thorsten Franz Jens Passauer Thorsten Haufe Peter Gross Gerhard Ehninger Eberhard Schleyer

Cancer Chemother Pharmacol 2003 Mar 4;51(3):266-70. Epub 2003 Mar 4.

Department of Medicine I, University Hospital Carl Gustav Carus at the Technical University Dresden, Fetscherstr 48, 01307, Dresden, Germany.

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March 2003

Application of cisplatin as intraoperative hyperthermic peritoneal lavage (IHPL) in patients with locally advanced gastric cancer: analysis of pharmacokinetics and of nephrotoxicity.

Authors:

Wolfgang Kern Jan Braess Marion Kotschofsky Stefan Samel Heinz Becker Wolfgang Hiddemann Eberhard Schleyer

Anticancer Res 2002 Sep-Oct;22(5):3099-102

University Hospital Grosshadern, Department of Internal Medicine III, Ludwig-Maximilians-University, 81366 München, Germany.

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February 2003

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