Publications by authors named "Dumitru A Iacobas"

44Publications

Cellular Environment Remodels the Genomic Fabrics of Functional Pathways in Astrocytes.

Genes (Basel) 2020 May 7;11(5). Epub 2020 May 7.

DP Purpura Department of Neuroscience, Albert Einstein College of Medicine, New York, NY 10461, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/genes11050520DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290327PMC
May 2020

Pulmonary Hypertension Remodels the Genomic Fabrics of Major Functional Pathways.

Genes (Basel) 2020 01 23;11(2). Epub 2020 Jan 23.

Personalized Genomics Laboratory, Center for Computational Systems Biology, Roy G Perry College of Engineering, Prairie View A&M University, Prairie View, TX 77446, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/genes11020126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7074533PMC
January 2020

Coordinated Activity of Transcriptional Networks Responding to the Pattern of Action Potential Firing in Neurons.

Genes (Basel) 2019 09 26;10(10). Epub 2019 Sep 26.

Section on Nervous System Development and Plasticity, the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), NIH, Bethesda, MD 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/genes10100754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826514PMC
September 2019

The Gene Master Regulators (GMR) Approach Provides Legitimate Targets for Personalized, Time-Sensitive Cancer Gene Therapy.

Genes (Basel) 2019 07 25;10(8). Epub 2019 Jul 25.

Personalized Genomics Laboratory, Center for Computational Systems Biology, Roy G. Perry College of Engineering, Prairie View A&M University, Prairie View, TX 77446, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/genes10080560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723146PMC
July 2019

Regeneration of neurotransmission transcriptome in a model of epileptic encephalopathy after antiinflammatory treatment.

Neural Regen Res 2018 Oct;13(10):1715-1718

Department of Cell Biology & Anatomy, New York Medical College; Department of Neurology, New York Medical College; Department of Pediatrics, New York Medical College, Valhalla, NY, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/1673-5374.238607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128045PMC
October 2018

Estrogen Protects Neurotransmission Transcriptome During Status Epilepticus.

Front Neurosci 2018 20;12:332. Epub 2018 Jun 20.

Department of Cell Biology & Anatomy, New York Medical College, Valhalla, NY, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fnins.2018.00332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6019481PMC
June 2018

ACTH and PMX53 recover synaptic transcriptome alterations in a rat model of infantile spasms.

Sci Rep 2018 04 10;8(1):5722. Epub 2018 Apr 10.

New York Medical College School of Medicine, Department of Cell Biology and Anatomy, Valhalla, NY, 10595, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-018-24013-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5893534PMC
April 2018

Gene master regulators of papillary and anaplastic thyroid cancers.

Oncotarget 2018 Jan 19;9(2):2410-2424. Epub 2017 Dec 19.

Department of Microbiology & Immunology, New York Medical College, Valhalla, NY, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/oncotarget.23417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788649PMC
January 2018

Functional genomic fabrics are remodeled in a mouse model of Chagasic cardiomyopathy and restored following cell therapy.

Microbes Infect 2018 03 20;20(3):185-195. Epub 2017 Nov 20.

Center for Computational Systems Biology at Prairie View A&M University, TX 77446, USA; Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx NY, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.micinf.2017.11.003DOI Listing
March 2018

Gene networks activated by specific patterns of action potentials in dorsal root ganglia neurons.

Sci Rep 2017 03 3;7:43765. Epub 2017 Mar 3.

Nervous System Development and Plasticity Section, the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), NIH, Bethesda, MD, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/srep43765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5335607PMC
March 2017

Synaptonuclear messenger PRR7 inhibits c-Jun ubiquitination and regulates NMDA-mediated excitotoxicity.

EMBO J 2016 09 25;35(17):1923-34. Epub 2016 Jul 25.

Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY, USA Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, NY, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15252/embj.201593070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007554PMC
September 2016

Postnatal glucocorticoid-induced hypomyelination, gliosis, and neurologic deficits are dose-dependent, preparation-specific, and reversible.

Exp Neurol 2015 Jan 28;263:200-13. Epub 2014 Sep 28.

Department of Pediatrics, Regional Neonatal Center, Maria Fareri Children's Hospital at Westchester Medical Center-New York Medical College, Valhalla, NY, USA; Department of Cell Biology and Anatomy, Regional Neonatal Center, Maria Fareri Children's Hospital at Westchester Medical Center-New York Medical College, Valhalla, NY, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.expneurol.2014.09.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4262645PMC
January 2015

Plasticity of the myelination genomic fabric.

Mol Genet Genomics 2012 Mar 13;287(3):237-46. Epub 2012 Jan 13.

D.P. Purpura Department of Neuroscience, Kennedy Center, Albert Einstein College of Medicine of Yeshiva University, Room 713, 1300 Morris Park Avenue, Bronx-New York, NY, 10461, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00438-012-0673-0DOI Listing
March 2012

Astrocyte proximity modulates the myelination gene fabric of oligodendrocytes.

Neuron Glia Biol 2010 Aug 5;6(3):157-69. Epub 2011 Jan 5.

Neuroscience, Albert Einstein College of Medicine, New York, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/S1740925X10000220DOI Listing
August 2010

Alterations in the Brain Transcriptome in ANKA Infected Mice.

J Neuroparasitology 2010 Oct;1

Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA ; Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3587055PMC
October 2010

Heart rhythm genomic fabric in hypoxia.

Biochem Biophys Res Commun 2010 Jan 31;391(4):1769-74. Epub 2009 Dec 31.

DP Purupura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2009.12.151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2849310PMC
January 2010

Alteration of transcriptomic networks in adoptive-transfer experimental autoimmune encephalomyelitis.

Front Integr Neurosci 2007 30;1:10. Epub 2007 Dec 30.

Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/neuro.07.010.2007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2526015PMC
December 2009

Effect of microgravity on gene expression in mouse brain.

Exp Brain Res 2008 Nov 14;191(3):289-300. Epub 2008 Aug 14.

Department of General and Environmental Physiology, Centre of Excellence in Comparative Genomics (CEGBA), University of Bari, via Amendola 165/A, 70126 Bari, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00221-008-1523-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651838PMC
November 2008

Similar transcriptomic alterations in Cx43 knockdown and knockout astrocytes.

Cell Commun Adhes 2008 May;15(1):195-206

Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/15419060802014222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2583241PMC
May 2008

Integrated transcriptomic response to cardiac chronic hypoxia: translation regulators and response to stress in cell survival.

Funct Integr Genomics 2008 Aug 1;8(3):265-75. Epub 2008 May 1.

DP Purpura Department of Neuroscience, Kennedy Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10142-008-0082-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856931PMC
August 2008

Gap junction and purinergic P2 receptor proteins as a functional unit: insights from transcriptomics.

J Membr Biol 2007 Jun 31;217(1-3):83-91. Epub 2007 Jul 31.

Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00232-007-9039-7DOI Listing
June 2007

Organizational principles of the connexin-related brain transcriptome.

J Membr Biol 2007 Aug 27;218(1-3):39-47. Epub 2007 Jul 27.

Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, NY 10461, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00232-007-9049-5DOI Listing
August 2007

Fluid shear stress upregulates vascular endothelial growth factor gene expression in osteoblasts.

Ann N Y Acad Sci 2007 Nov 23;1117:73-81. Epub 2007 Jul 23.

Department of Neuroscience, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York, New York 10461, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1196/annals.1402.020DOI Listing
November 2007

Connexin-dependent transcellular transcriptomic networks in mouse brain.

Prog Biophys Mol Biol 2007 May-Jun;94(1-2):169-85. Epub 2007 Apr 3.

Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, New York, NY, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pbiomolbio.2007.03.015DOI Listing
August 2007

The role of connexins in controlling cell growth and gene expression.

Prog Biophys Mol Biol 2007 May-Jun;94(1-2):245-64. Epub 2007 Mar 16.

Institute of Cardiovascular Sciences, University of Manitoba and St Boniface Research Centre, Winnipeg, MAN, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pbiomolbio.2007.03.009DOI Listing
August 2007

Connexin43 and the brain transcriptome of newborn mice.

Genomics 2007 Jan 24;89(1):113-23. Epub 2006 Oct 24.

Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ygeno.2006.09.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651831PMC
January 2007

Transcriptomic changes in developing kidney exposed to chronic hypoxia.

Biochem Biophys Res Commun 2006 Oct 18;349(1):329-38. Epub 2006 Aug 18.

Department of Neuroscience, Kennedy Center, Room #915C, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, New York, NY 10461, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2006.08.056DOI Listing
October 2006

A stochastic two-dimensional model of intercellular Ca2+ wave spread in glia.

Biophys J 2006 Jan 7;90(1):24-41. Epub 2005 Oct 7.

Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1529/biophysj.105.064378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1367023PMC
January 2006

Sensitivity of the brain transcriptome to connexin ablation.

Biochim Biophys Acta 2005 Jun 22;1711(2):183-96. Epub 2004 Dec 22.

Department of Neuroscience, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Kennedy Center, Room 915C, New York, NY 10461, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbamem.2004.12.002DOI Listing
June 2005

Gene expression and phenotypic characterization of mouse heart after chronic constant or intermittent hypoxia.

Physiol Genomics 2005 Aug 31;22(3):292-307. Epub 2005 May 31.

Departments of Pediatrics, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/physiolgenomics.00217.2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856928PMC
August 2005

Genes controlling multiple functional pathways are transcriptionally regulated in connexin43 null mouse heart.

Physiol Genomics 2005 Feb 7;20(3):211-23. Epub 2004 Dec 7.

Department of Neuroscience Albert Einstein College of Medicine, Bronx, New York 10461, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/physiolgenomics.00229.2003DOI Listing
February 2005

Gene expression alterations in connexin null mice extend beyond the gap junction.

Neurochem Int 2004 Jul-Aug;45(2-3):243-50

Department of Neuroscience, Albert Einstein College of Medicine, Kennedy Center, Room 915C, 1300 Morris Park Ave, Bronx, NY 10461, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuint.2003.12.008DOI Listing
July 2004

Array analysis of gene expression in connexin-43 null astrocytes.

Physiol Genomics 2003 Nov 11;15(3):177-90. Epub 2003 Nov 11.

Department of Neuroscience, Albert Einstein College of Medicine, New York 10461, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/physiolgenomics.00062.2003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651830PMC
November 2003

Microarray analysis of changes in gene expression in a murine model of chronic chagasic cardiomyopathy.

Parasitol Res 2003 Oct 9;91(3):187-96. Epub 2003 Aug 9.

Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00436-003-0937-zDOI Listing
October 2003

Hits and misses from gene expression ratio measurements in cDNA microarray studies.

J Biomol Tech 2002 Sep;13(3):143-57

Department of Neuroscience, Molecular Biology Core, Kennedy Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2279857PMC
September 2002