Publications by authors named "Donald J Zack"

100Publications

Human Organoids for the Study of Retinal Development and Disease.

Annu Rev Vis Sci 2020 Sep;6:91-114

Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA; email:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1146/annurev-vision-121219-081855DOI Listing
September 2020

Programmed switch in the mitochondrial degradation pathways during human retinal ganglion cell differentiation from stem cells is critical for RGC survival.

Redox Biol 2020 07 20;34:101465. Epub 2020 Apr 20.

Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA; Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.redox.2020.101465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327961PMC
July 2020

Single-Cell Analysis of Human Retina Identifies Evolutionarily Conserved and Species-Specific Mechanisms Controlling Development.

Dev Cell 2020 May 7;53(4):473-491.e9. Epub 2020 May 7.

John F. Hardesty, MD, Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.devcel.2020.04.009DOI Listing
May 2020

PanoView: An iterative clustering method for single-cell RNA sequencing data.

PLoS Comput Biol 2019 08 30;15(8):e1007040. Epub 2019 Aug 30.

Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pcbi.1007040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6742414PMC
August 2019

Egr2 overexpression in Schwann cells increases myelination frequency .

Heliyon 2018 Nov 29;4(11):e00982. Epub 2018 Nov 29.

Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD 21218, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.heliyon.2018.e00982DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275687PMC
November 2018

Highly efficient scarless knock-in of reporter genes into human and mouse pluripotent stem cells via transient antibiotic selection.

PLoS One 2018 29;13(11):e0201683. Epub 2018 Nov 29.

Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0201683PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264506PMC
April 2019

Inherited Retinal Degenerations: Current Landscape and Knowledge Gaps.

Transl Vis Sci Technol 2018 Jul 18;7(4). Epub 2018 Jul 18.

Institute of Ophthalmology and Visual Science, Rutgers-New Jersey Medical School, Rutgers University, Newark, NJ, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1167/tvst.7.4.6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052953PMC
July 2018

The Role of c-Jun N-Terminal Kinase (JNK) in Retinal Degeneration and Vision Loss.

Adv Exp Med Biol 2018 ;1074:351-357

The Wilmer Eye Institute, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-3-319-75402-4_43DOI Listing
May 2019

Role of SARM1 and DR6 in retinal ganglion cell axonal and somal degeneration following axonal injury.

Exp Eye Res 2018 06 8;171:54-61. Epub 2018 Mar 8.

Shiley Eye Institute, University of California, La Jolla, San Diego, CA 92037, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exer.2018.03.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964014PMC
June 2018

Longitudinal Analysis of Mouse SDOCT Volumes.

Proc SPIE Int Soc Opt Eng 2017 Feb 13;10137. Epub 2017 Mar 13.

Department of Electrical and Computer Engineering, Johns Hopkins University.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1117/12.2257432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5682106PMC
February 2017

Collagen vitrigels with low-fibril density enhance human embryonic stem cell-derived retinal pigment epithelial cell maturation.

J Tissue Eng Regen Med 2018 03 17;12(3):821-829. Epub 2017 Nov 17.

Wilmer Eye Institute, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/term.2598DOI Listing
March 2018

Enhanced Stem Cell Differentiation and Immunopurification of Genome Engineered Human Retinal Ganglion Cells.

Stem Cells Transl Med 2017 11 10;6(11):1972-1986. Epub 2017 Oct 10.

Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/sctm.17-0059
Publisher Site
http://dx.doi.org/10.1002/sctm.17-0059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430043PMC
November 2017

Automated segmentation of mouse OCT volumes (ASiMOV): Validation & clinical study of a light damage model.

PLoS One 2017 17;12(8):e0181059. Epub 2017 Aug 17.

Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore MD 21287 United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0181059PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560565PMC
October 2017

De novo assembly and annotation of the retinal transcriptome for the Nile grass rat (Arvicanthis ansorgei).

PLoS One 2017 31;12(7):e0179061. Epub 2017 Jul 31.

Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0179061PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536302PMC
October 2017

Enhanced Functional Genomic Screening Identifies Novel Mediators of Dual Leucine Zipper Kinase-Dependent Injury Signaling in Neurons.

Neuron 2017 Jun;94(6):1142-1154.e6

Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA; Solomon H. Snyder Department of Neuroscience, Department of Molecular Biology and Genetics, Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuron.2017.06.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5553555PMC
June 2017

A Triple-Fluorophore-Labeled Nucleic Acid pH Nanosensor to Investigate Non-viral Gene Delivery.

Mol Ther 2017 07 4;25(7):1697-1709. Epub 2017 May 4.

Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA; Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA; Institute for Nanobiotechnology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA; Department of Materials Science and Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA; Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA; Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ymthe.2017.04.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5498830PMC
July 2017

Photoreceptor Outer Segment-like Structures in Long-Term 3D Retinas from Human Pluripotent Stem Cells.

Sci Rep 2017 04 10;7(1):766. Epub 2017 Apr 10.

Wilmer Eye Institute, The Johns Hopkins Wilmer Eye Institute 600 N. Wolfe Street, Baltimore, MD, 21287, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-017-00774-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429674PMC
April 2017

Special Commentary: Early Clinical Development of Cell Replacement Therapy: Considerations for the National Eye Institute Audacious Goals Initiative.

Ophthalmology 2017 07 29;124(7):926-934. Epub 2017 Mar 29.

Department of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ophtha.2017.02.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5483186PMC
July 2017

Development of a Modular Automated System for Maintenance and Differentiation of Adherent Human Pluripotent Stem Cells.

SLAS Discov 2017 09 13;22(8):1016-1025. Epub 2017 Mar 13.

1 Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital & Department of Ophthalmology, the University of Melbourne, East Melbourne, Victoria, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2472555217696797DOI Listing
September 2017

Systematic Functional Testing of Rare Variants: Contributions of CFI to Age-Related Macular Degeneration.

Invest Ophthalmol Vis Sci 2017 03;58(3):1570-1576

Center for Human Disease Modeling, Duke University Medical Center, Durham, North Carolina, United States 2Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1167/iovs.16-20867DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6022411PMC
March 2017

Cornea organoids from human induced pluripotent stem cells.

Sci Rep 2017 01 27;7:41286. Epub 2017 Jan 27.

Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/srep41286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5269590PMC
January 2017

Off Target, but Sequence-Specific, shRNA-Associated Trans-Activation of Promoter Reporters in Transient Transfection Assays.

PLoS One 2016 15;11(12):e0167867. Epub 2016 Dec 15.

Department of Ophthalmology, Wilmer Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0167867PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5158200PMC
July 2017

Age at natural menopause genetic risk score in relation to age at natural menopause and primary open-angle glaucoma in a US-based sample.

Menopause 2017 02;24(2):150-156

1Department of Ophthalmology, Massachusetts Eye and Ear Infirmary 2Channing Division of Network Medicine, Brigham and Women's Hospital 3Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard Medical School, Boston, MA 4Department of Epidemiology and Biostatistics 5Institute of Computational Biology, Case Western Reserve University School of Medicine, Cleveland, OH 6Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 7Department of Ophthalmology 8Department of Medicine, Duke University, Duke University Medical Center, Durham, NC 9Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 10Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI 11Center for Human Genetics, Marshfield Clinic Research Foundation, Marshfield, WI 12Department of Ophthalmology, UPMC Eye Center, University of Pittsburgh, Pittsburgh, PA 13Departments of Ophthalmology and Anatomy/Cell Biology, University of Iowa, College of Medicine, Iowa City, IO 14Department of Ophthalmology, University of North Carolina, Chapel Hill, NC 15Department of Ophthalmology, WVU Eye Institute, Morgantown, WV 16Scripps Genome Center, University of California at San Diego, San Diego, CA 17Emmes Corporation, Chevy Chase, MD 18Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL 19Department of Ophthalmology, Stanford University, Palo Alto, CA 20Department of Ophthalmology, Mayo Clinic, Rochester, MN 21Wills Eye Institute, Philadelphia, PA 22Einhorn Clinical Research Center, New York Eye and Ear Infirmary of Mount Sinai, New York, NY 23Department of Ophthalmology, Case Western Reserve University School of Medicine, Cleveland, OH 24Department of Ophthalmology & Visual Sciences, University of Nebraska Medical Center, Omaha, NE 25Department of Genetics; Stanford University, Palo Alto, CA 26Wilmer Eye Institute, Johns Hopkins University Hospital, Baltimore, MD 27Department of Ophthalmology, Hamilton Eye Center; University of California at San Diego, San Diego, CA 28Department of Cellular Biology & Anatomy, Augusta University, Augusta, GA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/GME.0000000000000741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5266624PMC
February 2017

Characterization of intravitreally delivered capsid mutant AAV2-Cre vector to induce tissue-specific mutations in murine retinal ganglion cells.

Exp Eye Res 2016 10 30;151:61-7. Epub 2016 Jul 30.

Department of Biology, 951 Carrier Drive, MSC 7801, James Madison University, Harrisonburg, VA, 22807, USA; Center for Genome & Metagenome Studies, 951 Carrier Drive, MSC 7801, James Madison University, Harrisonburg, VA, 22807, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exer.2016.07.019DOI Listing
October 2016

Serum molecular signature for proliferative diabetic retinopathy in Saudi patients with type 2 diabetes.

Mol Vis 2016 11;22:636-45. Epub 2016 Jun 11.

Vitreoretina Division, King Khaled Eye Specialist Hospital, Riyadh 11462, Kingdom of Saudi Arabia.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4902182PMC
January 2018

The Potential of Human Stem Cells for the Study and Treatment of Glaucoma.

Invest Ophthalmol Vis Sci 2016 Apr;57(5):ORSFi1-6

Department of Ophthalmology Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States 2Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland, United State.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1167/iovs.15-18590DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5110236PMC
April 2016

Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open-angle glaucoma.

Nat Genet 2016 Feb 11;48(2):189-94. Epub 2016 Jan 11.

Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA.

View Article

Download full-text PDF

Source
http://search.proquest.com/openview/9583d4c1af74c01602d422b2
Web Search
http://www.nature.com/doifinder/10.1038/ng.3482
Publisher Site
http://dx.doi.org/10.1038/ng.3482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731307PMC
February 2016

Resolving complex research data management issues in biomedical laboratories: Qualitative study of an industry-academia collaboration.

Comput Methods Programs Biomed 2016 Apr 12;126:160-70. Epub 2015 Nov 12.

Departments of Pathology, Genetic Medicine, Health Sciences Informatics, Oncology, and Urology, Johns Hopkins University School of Medicine, Baltimore, MD, United States; Wilmer Eye Institute, United States; Institute of Genetic Medicine Johns Hopkins University School of Medicine, Baltimore, MD, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cmpb.2015.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778387PMC
April 2016

Use of a Machine Learning-Based High Content Analysis Approach to Identify Photoreceptor Neurite Promoting Molecules.

Adv Exp Med Biol 2016 ;854:597-603

Ophthalmology, Molecular Biology & Genetics, Neuroscience, and Institute of Genetic Medicine, Wilmer Eye Institute, Johns Hopkins University School of Medicine, 400 N Broadway, Smith 3001, 21231, Baltimore, MD, USA.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/978-3-319-17121-0_79
Publisher Site
http://dx.doi.org/10.1007/978-3-319-17121-0_79DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815518PMC
April 2016

Small-molecule-directed, efficient generation of retinal pigment epithelium from human pluripotent stem cells.

Proc Natl Acad Sci U S A 2015 Sep 12;112(35):10950-5. Epub 2015 Aug 12.

Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287; Department of Molecular Biology and Genetics, Johns Hopkins University, Baltimore, MD 21287; Department of Neuroscience, Johns Hopkins University, Baltimore, MD 21287; Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1422818112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568212PMC
September 2015

Gene regulation: it matters who you hang out with.

Neuron 2015 Apr;86(1):7-9

Wilmer Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuron.2015.03.057DOI Listing
April 2015

Characterization of tissue-specific differential DNA methylation suggests distinct modes of positive and negative gene expression regulation.

BMC Genomics 2015 Feb 5;16:49. Epub 2015 Feb 5.

Department of Ophthalmology, Wilmer Institute, Johns Hopkins University School of Medicine, Baltimore, MA, USA.

View Article

Download full-text PDF

Source
http://www.biomedcentral.com/1471-2164/16/49
Publisher Site
http://dx.doi.org/10.1186/s12864-015-1271-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4331481PMC
February 2015

The transcription factor GTF2IRD1 regulates the topology and function of photoreceptors by modulating photoreceptor gene expression across the retina.

J Neurosci 2014 Nov;34(46):15356-68

Department of Ophthalmology, Wilmer Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, Departments of Molecular Biology and Genetics, Neuroscience, Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, and Institut de la Vision, University Pierre and Marie Curie, Paris 75012, France

View Article

Download full-text PDF

Source
http://www.jneurosci.org/cgi/doi/10.1523/JNEUROSCI.2089-14.2
Publisher Site
http://dx.doi.org/10.1523/JNEUROSCI.2089-14.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4228138PMC
November 2014

Expansion of the CRISPR-Cas9 genome targeting space through the use of H1 promoter-expressed guide RNAs.

Nat Commun 2014 Aug 8;5:4516. Epub 2014 Aug 8.

1] Department of Ophthalmology, Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA [2] Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA [3] Solomon H. Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA [4] Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA [5] Department of Genetics, Institut de la Vision, 17 rue Moreau, 75012 Paris, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncomms5516DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133144PMC
August 2014

Stem cells, retinal ganglion cells and glaucoma.

Dev Ophthalmol 2014 10;53:111-21. Epub 2014 Apr 10.

Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Md., USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000358409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547935PMC
January 2015

A high content screening approach to identify molecules neuroprotective for photoreceptor cells.

Adv Exp Med Biol 2014 ;801:773-81

Wilmer Eye Institute, Johns Hopkins University School of Medicine, 400 N Broadway, 21231, Baltimore, MD, USA,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4614-3209-8_97DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155743PMC
July 2014

Modeling retinal dystrophies using patient-derived induced pluripotent stem cells.

Adv Exp Med Biol 2014 ;801:157-64

Department of Ophthalmology, The Johns Hopkins University School of Medicine, Smith Building Rm 3029, 400 N Broadway, Baltimore, MD, USA,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4614-3209-8_20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117190PMC
July 2014

The Pex1-G844D mouse: a model for mild human Zellweger spectrum disorder.

Mol Genet Metab 2014 Apr 23;111(4):522-532. Epub 2014 Jan 23.

Department of Neurogenetics, Hugo W. Moser Research Institute at Kennedy Krieger, 707 N. Broadway, Baltimore, MD, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ymgme.2014.01.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4901203PMC
April 2014

Evaluating the potential of poly(beta-amino ester) nanoparticles for reprogramming human fibroblasts to become induced pluripotent stem cells.

Int J Nanomedicine 2013 4;8:4641-58. Epub 2013 Dec 4.

Department of Biomedical Engineering, Translational Tissue Engineering Center, and Institute for Nanobiotechnology, Baltimore, MD, USA ; Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/IJN.S53830DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857166PMC
June 2014

Epigenetics and cell death: DNA hypermethylation in programmed retinal cell death.

PLoS One 2013 11;8(11):e79140. Epub 2013 Nov 11.

Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0079140PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823652PMC
August 2014

Integrative analysis of tissue-specific methylation and alternative splicing identifies conserved transcription factor binding motifs.

Nucleic Acids Res 2013 Oct 24;41(18):8503-14. Epub 2013 Jul 24.

Department of Ophthalmology, Wilmer Institute, Johns Hopkins University School of Medicine, 600 North Wolfe Street, 21287 Baltimore, MD, USA, Department of Pharmacology and Molecular Science, Johns Hopkins University School of Medicine, 600 North Wolfe Street, 21287 Baltimore, MD, USA, Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, 600 North Wolfe Street, 21287 Baltimore, MD, USA, Department of Neuroscience, Johns Hopkins University School of Medicine, 600 North Wolfe Street, 21287 Baltimore, MD, USA, Institute of Genetic Medicine, Johns Hopkins University School of Medicine, 600 North Wolfe Street, 21287 Baltimore, MD, USA and Institut de la Vision, 17 rue Moreau, 75012 Paris, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gkt652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3794605PMC
October 2013

A novel methyl-binding domain protein enrichment method for identifying genome-wide tissue-specific DNA methylation from nanogram DNA samples.

Epigenetics Chromatin 2013 Jun 7;6(1):17. Epub 2013 Jun 7.

Department of Ophthalmology, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1756-8935-6-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680319PMC
June 2013

Seven new loci associated with age-related macular degeneration.

Authors:
Lars G Fritsche Wei Chen Matthew Schu Brian L Yaspan Yi Yu Gudmar Thorleifsson Donald J Zack Satoshi Arakawa Valentina Cipriani Stephan Ripke Robert P Igo Gabriëlle H S Buitendijk Xueling Sim Daniel E Weeks Robyn H Guymer Joanna E Merriam Peter J Francis Gregory Hannum Anita Agarwal Ana Maria Armbrecht Isabelle Audo Tin Aung Gaetano R Barile Mustapha Benchaboune Alan C Bird Paul N Bishop Kari E Branham Matthew Brooks Alexander J Brucker William H Cade Melinda S Cain Peter A Campochiaro Chi-Chao Chan Ching-Yu Cheng Emily Y Chew Kimberly A Chin Itay Chowers David G Clayton Radu Cojocaru Yvette P Conley Belinda K Cornes Mark J Daly Baljean Dhillon Albert O Edwards Evangelos Evangelou Jesen Fagerness Henry A Ferreyra James S Friedman Asbjorg Geirsdottir Ronnie J George Christian Gieger Neel Gupta Stephanie A Hagstrom Simon P Harding Christos Haritoglou John R Heckenlively Frank G Holz Guy Hughes John P A Ioannidis Tatsuro Ishibashi Peronne Joseph Gyungah Jun Yoichiro Kamatani Nicholas Katsanis Claudia N Keilhauer Jane C Khan Ivana K Kim Yutaka Kiyohara Barbara E K Klein Ronald Klein Jaclyn L Kovach Igor Kozak Clara J Lee Kristine E Lee Peter Lichtner Andrew J Lotery Thomas Meitinger Paul Mitchell Saddek Mohand-Saïd Anthony T Moore Denise J Morgan Margaux A Morrison Chelsea E Myers Adam C Naj Yusuke Nakamura Yukinori Okada Anton Orlin M Carolina Ortube Mohammad I Othman Chris Pappas Kyu Hyung Park Gayle J T Pauer Neal S Peachey Olivier Poch Rinki Ratna Priya Robyn Reynolds Andrea J Richardson Raymond Ripp Guenther Rudolph Euijung Ryu José-Alain Sahel Debra A Schaumberg Hendrik P N Scholl Stephen G Schwartz William K Scott Humma Shahid Haraldur Sigurdsson Giuliana Silvestri Theru A Sivakumaran R Theodore Smith Lucia Sobrin Eric H Souied Dwight E Stambolian Hreinn Stefansson Gwen M Sturgill-Short Atsushi Takahashi Nirubol Tosakulwong Barbara J Truitt Evangelia E Tsironi André G Uitterlinden Cornelia M van Duijn Lingam Vijaya Johannes R Vingerling Eranga N Vithana Andrew R Webster H-Erich Wichmann Thomas W Winkler Tien Y Wong Alan F Wright Diana Zelenika Ming Zhang Ling Zhao Kang Zhang Michael L Klein Gregory S Hageman G Mark Lathrop Kari Stefansson Rando Allikmets Paul N Baird Michael B Gorin Jie Jin Wang Caroline C W Klaver Johanna M Seddon Margaret A Pericak-Vance Sudha K Iyengar John R W Yates Anand Swaroop Bernhard H F Weber Michiaki Kubo Margaret M Deangelis Thierry Léveillard Unnur Thorsteinsdottir Jonathan L Haines Lindsay A Farrer Iris M Heid Gonçalo R Abecasis

Nat Genet 2013 Apr 3;45(4):433-9, 439e1-2. Epub 2013 Mar 3.

Institute of Human Genetics, University of Regensburg, Regensburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ng.2578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3739472PMC
April 2013

Dynamics of regulatory networks in the developing mouse retina.

PLoS One 2012 3;7(10):e46521. Epub 2012 Oct 3.

Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0046521PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463606PMC
June 2013

Retinal ganglion cell morphology after optic nerve crush and experimental glaucoma.

Invest Ophthalmol Vis Sci 2012 Jun 22;53(7):3847-57. Epub 2012 Jun 22.

Department of Ophthalmology, Institute of Clinical Medicine, School of Medicine, University of Eastern Finland, Kuopio, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1167/iovs.12-9712DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3630905PMC
June 2012

Cell-specific DNA methylation patterns of retina-specific genes.

PLoS One 2012 5;7(3):e32602. Epub 2012 Mar 5.

Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0032602PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293830PMC
July 2012

Hydrocortisone stimulates neurite outgrowth from mouse retinal explants by modulating macroglial activity.

Invest Ophthalmol Vis Sci 2012 Apr 24;53(4):2046-61. Epub 2012 Apr 24.

Department of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA.

View Article

Download full-text PDF

Source
http://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.1
Publisher Site
http://dx.doi.org/10.1167/iovs.11-8646DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3704200PMC
April 2012

Semi-automated, quantitative analysis of retinal ganglion cell morphology in mice selectively expressing yellow fluorescent protein.

Exp Eye Res 2012 Mar 22;96(1):107-15. Epub 2011 Dec 22.

Glaucoma Center of Excellence, Wilmer Ophthalmological Institute, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287-9205, USA.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S001448351100410
Publisher Site
http://dx.doi.org/10.1016/j.exer.2011.12.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419383PMC
March 2012

Dynamic usage of alternative splicing exons during mouse retina development.

Nucleic Acids Res 2011 Oct 30;39(18):7920-30. Epub 2011 Jun 30.

Wilmer Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gkr545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185435PMC
October 2011

Lack of neuroprotection against experimental glaucoma in c-Jun N-terminal kinase 3 knockout mice.

Exp Eye Res 2011 Apr 25;92(4):299-305. Epub 2011 Jan 25.

Glaucoma Research Laboratory, Wilmer Eye Institute, 600 North Wolfe Street, Johns Hopkins University School of Medicine, Baltimore, MD 21287-9205, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exer.2011.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060951PMC
April 2011

Generation of Cre transgenic mice with postnatal RPE-specific ocular expression.

Invest Ophthalmol Vis Sci 2011 Mar 14;52(3):1378-83. Epub 2011 Mar 14.

F. M. Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1167/iovs.10-6347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101664PMC
March 2011

Alternative splicing of neuroligin and its protein distribution in the outer plexiform layer of the chicken retina.

J Comp Neurol 2010 Dec;518(24):4938-62

Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/cne.22499
Publisher Site
http://dx.doi.org/10.1002/cne.22499DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4065168PMC
December 2010

What has gene expression profiling taught us about glaucoma?

Exp Eye Res 2011 Aug 12;93(2):191-5. Epub 2010 Oct 12.

Department of Ophthalmology, Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exer.2010.10.001DOI Listing
August 2011

Computational analysis of tissue-specific gene networks: application to murine retinal functional studies.

Bioinformatics 2010 Sep 8;26(18):2289-97. Epub 2010 Jul 8.

Wilmer Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

View Article

Download full-text PDF

Source
https://academic.oup.com/bioinformatics/article-lookup/doi/1
Publisher Site
http://dx.doi.org/10.1093/bioinformatics/btq408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2935398PMC
September 2010