Dominic P Kwiatkowski

Dominic P Kwiatkowski

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Dominic P Kwiatkowski

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Triple artemisinin-based combination therapies versus artemisinin-based combination therapies for uncomplicated Plasmodium falciparum malaria: a multicentre, open-label, randomised clinical trial.

Lancet 2020 Mar 11. Epub 2020 Mar 11.

Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK. Electronic address:

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http://dx.doi.org/10.1016/S0140-6736(20)30552-3DOI Listing
March 2020

Origins of the current outbreak of multidrug-resistant malaria in southeast Asia: a retrospective genetic study.

Lancet Infect Dis 2018 03 2;18(3):337-345. Epub 2018 Feb 2.

Wellcome Sanger Institute, Hinxton, UK; MRC Centre for Genomics and Global Health, Big Data Institute, Oxford University, Oxford, UK. Electronic address:

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http://dx.doi.org/10.1016/S1473-3099(18)30068-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835763PMC
March 2018

Population genetic structure and adaptation of malaria parasites on the edge of endemic distribution.

Mol Ecol 2017 Jun 15;26(11):2880-2894. Epub 2017 Mar 15.

Department of Pathogen Molecular Biology, London School of Hygiene & Tropical Medicine, Keppel St, London, WC1E 7HT, UK.

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http://dx.doi.org/10.1111/mec.14066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485074PMC
June 2017

Characterisation of the opposing effects of G6PD deficiency on cerebral malaria and severe malarial anaemia.

Elife 2017 01 9;6. Epub 2017 Jan 9.

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.7554/eLife.15085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5222559PMC
January 2017

Culture adaptation of malaria parasites selects for convergent loss-of-function mutants.

Sci Rep 2017 01 24;7:41303. Epub 2017 Jan 24.

London School of Hygiene and Tropical Medicine, London, UK.

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http://dx.doi.org/10.1038/srep41303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5259787PMC
January 2017

Analysis of anti-malarial resistance markers in pfmdr1 and pfcrt across Southeast Asia in the Tracking Resistance to Artemisinin Collaboration.

Malar J 2016 Nov 8;15(1):541. Epub 2016 Nov 8.

Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

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http://dx.doi.org/10.1186/s12936-016-1598-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101715PMC
November 2016

Genomic Analysis Reveals a Common Breakpoint in Amplifications of the Plasmodium vivax Multidrug Resistance 1 Locus in Thailand.

J Infect Dis 2016 10 24;214(8):1235-42. Epub 2016 Jul 24.

Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University, Australia Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, Oxford University, United Kingdom.

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http://dx.doi.org/10.1093/infdis/jiw323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034950PMC
October 2016

Severe anemia in Malawian children.

Malawi Med J 2016 09;28(3):99-107

Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi; College of Medicine, University of Malawi, Blantyre, Malawi; Emma Children's Hospital, the Global Child Health Group, Academic Medical Center, Amsterdam, The Netherlands; Child and Reproductive Health Group, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5116999PMC
September 2016

Environmental Correlation Analysis for Genes Associated with Protection against Malaria.

Mol Biol Evol 2016 05 6;33(5):1188-204. Epub 2016 Jan 6.

Department of Epidemiology and Demography, KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya Department of Medicine, Imperial College, London, United Kingdom INDEPTH Network, Kanda, Accra, Ghana.

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http://dx.doi.org/10.1093/molbev/msw004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839215PMC
May 2016

The ethics of sustainable genomic research in Africa.

Genome Biol 2016 Mar 8;17:44. Epub 2016 Mar 8.

The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.

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http://dx.doi.org/10.1186/s13059-016-0914-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782358PMC
March 2016

A genome wide association study of Plasmodium falciparum susceptibility to 22 antimalarial drugs in Kenya.

PLoS One 2014 8;9(5):e96486. Epub 2014 May 8.

Medical Research Council (MRC) Centre for Genomics and Global Health, University of Oxford, Oxford, United Kingdom; Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0096486PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014544PMC
October 2015

Glucose-6-phosphate dehydrogenase deficiency and the risk of malaria and other diseases in children in Kenya: a case-control and a cohort study.

Lancet Haematol 2015 Oct 22;2(10):e437-44. Epub 2015 Sep 22.

Department of Epidemiology and Demography, KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya; Department of Medicine, Imperial College, St Mary's Hospital, London, UK. Electronic address:

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http://dx.doi.org/10.1016/S2352-3026(15)00152-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703047PMC
October 2015

Comparison of genomic signatures of selection on Plasmodium falciparum between different regions of a country with high malaria endemicity.

BMC Genomics 2015 Jul 16;16:527. Epub 2015 Jul 16.

West African Centre for Cell Biology of Infectious Pathogens (WACCBIP), Department of Biochemistry, Cell and Molecular Biology, University of Ghana, Box LG 54, Volta Road, Legon, Accra, Ghana.

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http://dx.doi.org/10.1186/s12864-015-1746-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502944PMC
July 2015

G6PD gene variants and its association with malaria in a Sri Lankan population.

Malar J 2015 Feb 22;14:93. Epub 2015 Feb 22.

Department of Parasitology, Faculty of Medicine, University of Colombo, 25, Kynsey Road, Colombo 08, Sri Lanka.

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http://dx.doi.org/10.1186/s12936-015-0603-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4343272PMC
February 2015

Optimized whole-genome amplification strategy for extremely AT-biased template.

DNA Res 2014 Dec 19;21(6):661-71. Epub 2014 Sep 19.

Wellcome Trust Sanger Institute, Hinxton, UK MRC Centre for Genomics and Global Health, University of Oxford, Oxford OX3 7BN, UK Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.

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http://dx.doi.org/10.1093/dnares/dsu028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263299PMC
December 2014

Monitoring parasite diversity for malaria elimination in sub-Saharan Africa.

Science 2014 Sep;345(6202):1297-8

Malaria Research and Training Centre (MRTC), Department of Epidemiology of Parasitic Diseases, Faculty of Pharmacy, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali. Wellcome Trust Sanger Institute, Hinxton, UK.

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http://dx.doi.org/10.1126/science.1259423DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4541720PMC
September 2014

Knowing who to trust: exploring the role of 'ethical metadata' in mediating risk of harm in collaborative genomics research in Africa.

BMC Med Ethics 2014 Aug 13;15:62. Epub 2014 Aug 13.

Department of Medicine, University of Cape Town, Anzio Road Observatory, Cape Town 7925, South Africa.

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http://dx.doi.org/10.1186/1472-6939-15-62DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146449PMC
August 2014

Spread of artemisinin resistance in Plasmodium falciparum malaria.

N Engl J Med 2014 Jul;371(5):411-23

The authors' affiliations are listed in the Appendix.

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http://dx.doi.org/10.1056/NEJMoa1314981DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143591PMC
July 2014

Genome-wide analysis of selection on the malaria parasite Plasmodium falciparum in West African populations of differing infection endemicity.

Mol Biol Evol 2014 Jun 18;31(6):1490-9. Epub 2014 Mar 18.

Pathogen Molecular Biology Department, London School of Hygiene and Tropical Medicine, London, United KingdomMedical Research Council Unit, Fajara, Banjul, The Gambia

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http://dx.doi.org/10.1093/molbev/msu106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032133PMC
June 2014

Natural selection and infectious disease in human populations.

Nat Rev Genet 2014 Jun 29;15(6):379-93. Epub 2014 Apr 29.

1] Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA. [2] Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts 02142, USA. [3] Department of Immunology and Infectious Disease, Harvard School of Public Health, Boston, Massachusetts 02115, USA.

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http://search.proquest.com/openview/f0ddd58e5fa662772806ff56
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http://dx.doi.org/10.1038/nrg3734DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912034PMC
June 2014

A transcriptional switch underlies commitment to sexual development in malaria parasites.

Nature 2014 Mar 23;507(7491):248-52. Epub 2014 Feb 23.

1] Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544, USA [2] Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA [3] Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA (B.F.C.K.); Department of Molecular Biology and Center for Infectious Disease Dynamics, The Pennsylvania State University, State College, Pennsylvania 16802, USA (V.M.C., M.L.).

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http://dx.doi.org/10.1038/nature12920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4040541PMC
March 2014

Detecting and characterizing genomic signatures of positive selection in global populations.

Am J Hum Genet 2013 Jun 23;92(6):866-81. Epub 2013 May 23.

NUS Graduate School for Integrative Science and Engineering, National University of Singapore, Singapore 117456, Singapore; Saw Swee Hock School of Public Health, National University of Singapore, Singapore 117597, Singapore.

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http://dx.doi.org/10.1016/j.ajhg.2013.04.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675259PMC
June 2013

An optimized microarray platform for assaying genomic variation in Plasmodium falciparum field populations.

Genome Biol 2011 8;12(4):R35. Epub 2011 Apr 8.

The Eck Institute for Global Health, University of Notre Dame, 100 Galvin Life Sciences, Notre Dame, IN 46556, USA.

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http://dx.doi.org/10.1186/gb-2011-12-4-r35DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218861PMC
February 2012

Candidate malaria susceptibility/protective SNPs in hospital and population-based studies: the effect of sub-structuring.

Malar J 2010 May 8;9:119. Epub 2010 May 8.

Department of Molecular Biology, Institute of Endemic Diseases, Medical Campus, Qasser Street, University of Khartoum, Khartoum, Sudan.

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http://dx.doi.org/10.1186/1475-2875-9-119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2877684PMC
May 2010

Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls.

Authors:
Nick Craddock Matthew E Hurles Niall Cardin Richard D Pearson Vincent Plagnol Samuel Robson Damjan Vukcevic Chris Barnes Donald F Conrad Eleni Giannoulatou Chris Holmes Jonathan L Marchini Kathy Stirrups Martin D Tobin Louise V Wain Chris Yau Jan Aerts Tariq Ahmad T Daniel Andrews Hazel Arbury Anthony Attwood Adam Auton Stephen G Ball Anthony J Balmforth Jeffrey C Barrett Inês Barroso Anne Barton Amanda J Bennett Sanjeev Bhaskar Katarzyna Blaszczyk John Bowes Oliver J Brand Peter S Braund Francesca Bredin Gerome Breen Morris J Brown Ian N Bruce Jaswinder Bull Oliver S Burren John Burton Jake Byrnes Sian Caesar Chris M Clee Alison J Coffey John M C Connell Jason D Cooper Anna F Dominiczak Kate Downes Hazel E Drummond Darshna Dudakia Andrew Dunham Bernadette Ebbs Diana Eccles Sarah Edkins Cathryn Edwards Anna Elliot Paul Emery David M Evans Gareth Evans Steve Eyre Anne Farmer I Nicol Ferrier Lars Feuk Tomas Fitzgerald Edward Flynn Alistair Forbes Liz Forty Jayne A Franklyn Rachel M Freathy Polly Gibbs Paul Gilbert Omer Gokumen Katherine Gordon-Smith Emma Gray Elaine Green Chris J Groves Detelina Grozeva Rhian Gwilliam Anita Hall Naomi Hammond Matt Hardy Pile Harrison Neelam Hassanali Husam Hebaishi Sarah Hines Anne Hinks Graham A Hitman Lynne Hocking Eleanor Howard Philip Howard Joanna M M Howson Debbie Hughes Sarah Hunt John D Isaacs Mahim Jain Derek P Jewell Toby Johnson Jennifer D Jolley Ian R Jones Lisa A Jones George Kirov Cordelia F Langford Hana Lango-Allen G Mark Lathrop James Lee Kate L Lee Charlie Lees Kevin Lewis Cecilia M Lindgren Meeta Maisuria-Armer Julian Maller John Mansfield Paul Martin Dunecan C O Massey Wendy L McArdle Peter McGuffin Kirsten E McLay Alex Mentzer Michael L Mimmack Ann E Morgan Andrew P Morris Craig Mowat Simon Myers William Newman Elaine R Nimmo Michael C O'Donovan Abiodun Onipinla Ifejinelo Onyiah Nigel R Ovington Michael J Owen Kimmo Palin Kirstie Parnell David Pernet John R B Perry Anne Phillips Dalila Pinto Natalie J Prescott Inga Prokopenko Michael A Quail Suzanne Rafelt Nigel W Rayner Richard Redon David M Reid Renwick Susan M Ring Neil Robertson Ellie Russell David St Clair Jennifer G Sambrook Jeremy D Sanderson Helen Schuilenburg Carol E Scott Richard Scott Sheila Seal Sue Shaw-Hawkins Beverley M Shields Matthew J Simmonds Debbie J Smyth Elilan Somaskantharajah Katarina Spanova Sophia Steer Jonathan Stephens Helen E Stevens Millicent A Stone Zhan Su Deborah P M Symmons John R Thompson Wendy Thomson Mary E Travers Clare Turnbull Armand Valsesia Mark Walker Neil M Walker Chris Wallace Margaret Warren-Perry Nicholas A Watkins John Webster Michael N Weedon Anthony G Wilson Matthew Woodburn B Paul Wordsworth Allan H Young Eleftheria Zeggini Nigel P Carter Timothy M Frayling Charles Lee Gil McVean Patricia B Munroe Aarno Palotie Stephen J Sawcer Stephen W Scherer David P Strachan Chris Tyler-Smith Matthew A Brown Paul R Burton Mark J Caulfield Alastair Compston Martin Farrall Stephen C L Gough Alistair S Hall Andrew T Hattersley Adrian V S Hill Christopher G Mathew Marcus Pembrey Jack Satsangi Michael R Stratton Jane Worthington Panos Deloukas Audrey Duncanson Dominic P Kwiatkowski Mark I McCarthy Willem Ouwehand Miles Parkes Nazneen Rahman John A Todd Nilesh J Samani Peter Donnelly

Nature 2010 Apr;464(7289):713-20

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http://dx.doi.org/10.1038/nature08979DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892339PMC
April 2010

Methodological challenges of genome-wide association analysis in Africa.

Nat Rev Genet 2010 Feb;11(2):149-60

Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK.

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http://www.nature.com/articles/nrg2731
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http://dx.doi.org/10.1038/nrg2731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3769612PMC
February 2010

LookSeq: a browser-based viewer for deep sequencing data.

Genome Res 2009 Nov 13;19(11):2125-32. Epub 2009 Aug 13.

Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom.

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http://dx.doi.org/10.1101/gr.093443.109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2775587PMC
November 2009

Ethical data release in genome-wide association studies in developing countries.

PLoS Med 2009 Nov 24;6(11):e1000143. Epub 2009 Nov 24.

Ethox Centre, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1371/journal.pmed.1000143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771895PMC
November 2009

Genome-wide comparisons of variation in linkage disequilibrium.

Genome Res 2009 Oct 18;19(10):1849-60. Epub 2009 Jun 18.

Wellcome Trust Centre for Human Genetics, University of Oxford, United Kingdom.

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http://genome.cshlp.org/cgi/doi/10.1101/gr.092189.109
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http://dx.doi.org/10.1101/gr.092189.109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765270PMC
October 2009

SnoopCGH: software for visualizing comparative genomic hybridization data.

Bioinformatics 2009 Oct 16;25(20):2732-3. Epub 2009 Aug 16.

Wellcome Trust Sanger Institute, Hinxton, The Weatherall Institute of Molecular Medicine and Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.

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https://academic.oup.com/bioinformatics/article-lookup/doi/1
Publisher Site
http://dx.doi.org/10.1093/bioinformatics/btp488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2759554PMC
October 2009

SNP-o-matic.

Bioinformatics 2009 Sep 2;25(18):2434-5. Epub 2009 Jul 2.

Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.

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http://dx.doi.org/10.1093/bioinformatics/btp403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735664PMC
September 2009

Genome-wide and fine-resolution association analysis of malaria in West Africa.

Nat Genet 2009 Jun 24;41(6):657-65. Epub 2009 May 24.

MRC Laboratories, Fajara, Banjul, Gambia.

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http://dx.doi.org/10.1038/ng.388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2889040PMC
June 2009