Dieter Egli

Dieter Egli

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Dieter Egli

Publications by authors named "Dieter Egli"

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NanoMod: a computational tool to detect DNA modifications using Nanopore long-read sequencing data.

BMC Genomics 2019 Feb 4;20(Suppl 1):78. Epub 2019 Feb 4.

Raymond G. Perelman Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1186/s12864-018-5372-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360650PMC
February 2019

Ciliary gene RPGRIP1L is required for hypothalamic arcuate neuron development.

JCI Insight 2019 Feb 7;4(3). Epub 2019 Feb 7.

Naomi Berrie Diabetes Center & Division of Molecular Genetics, Department of Pediatrics, College of Physicians and Surgeons of Columbia University, New York, New York, USA.

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http://dx.doi.org/10.1172/jci.insight.123337DOI Listing
February 2019

ILDR2 has a negligible role in hepatic steatosis.

PLoS One 2018 30;13(5):e0197548. Epub 2018 May 30.

Naomi Berrie Diabetes Center and Division of Molecular Genetics, Department of Pediatrics, Columbia University, New York, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0197548PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976177PMC
December 2018

β Cell Replacement after Gene Editing of a Neonatal Diabetes-Causing Mutation at the Insulin Locus.

Stem Cell Reports 2018 Dec 29;11(6):1407-1415. Epub 2018 Nov 29.

Naomi Berrie Diabetes Center & Department of Pediatrics, College of Physicians and Surgeons, Columbia University Medical Center, New York, NY 10032, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22136711183047
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http://dx.doi.org/10.1016/j.stemcr.2018.11.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294262PMC
December 2018

Pancreatic Beta Cell Differentiation From Human Pluripotent Stem Cells.

Curr Protoc Hum Genet 2018 10 7;99(1):e68. Epub 2018 Sep 7.

Naomi Berrie Diabetes Center & Department of Pediatrics, College of Physicians and Surgeons, Columbia University Medical Center, New York.

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http://doi.wiley.com/10.1002/cphg.68
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http://dx.doi.org/10.1002/cphg.68DOI Listing
October 2018

Inter-homologue repair in fertilized human eggs?

Nature 2018 08 8;560(7717):E5-E7. Epub 2018 Aug 8.

Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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http://www.nature.com/articles/s41586-018-0379-5
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http://dx.doi.org/10.1038/s41586-018-0379-5DOI Listing
August 2018

Derivation and characterization of the NIH registry human stem cell line NYSCF100 line under defined feeder-free conditions.

Stem Cell Res 2018 05 31;29:99-102. Epub 2018 Mar 31.

The New York Stem Cell Foundation Research Institute, New York, NY 10019, United States.

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http://dx.doi.org/10.1016/j.scr.2018.03.017DOI Listing
May 2018

Derivation and characterization of the NIH registry human stem cell line NYSCF101 under defined feeder-free conditions.

Stem Cell Res 2018 05 30;29:197-201. Epub 2018 Apr 30.

The New York Stem Cell Foundation Research Institute, New York, NY 10019, United States.

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http://dx.doi.org/10.1016/j.scr.2018.04.017DOI Listing
May 2018

β-Cell Replacement in Mice Using Human Type 1 Diabetes Nuclear Transfer Embryonic Stem Cells.

Diabetes 2018 01 20;67(1):26-35. Epub 2017 Sep 20.

Naomi Berrie Diabetes Center and Department of Pediatrics, College of Physicians and Surgeons, Columbia University Medical Center, New York, NY

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http://dx.doi.org/10.2337/db17-0120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741143PMC
January 2018

Derivation and characterization of the NYSCFe003-A human embryonic stem cell line.

Stem Cell Res 2017 12 21;25:217-220. Epub 2017 Nov 21.

The New York Stem Cell Foundation Research Institute, NY 10019, New York, United States.

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http://dx.doi.org/10.1016/j.scr.2017.10.017DOI Listing
December 2017

Tying genetic stability to cell identity.

Cell Cycle 2017 Jun;16(12):1139-1140

b Department of Pediatrics, Department of Obstetrics and Gynecology , Columbia University , New York , NY , USA.

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http://dx.doi.org/10.1080/15384101.2017.1324126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499902PMC
June 2017

Genomic instability during reprogramming by nuclear transfer is DNA replication dependent.

Nat Cell Biol 2017 04 6;19(4):282-291. Epub 2017 Mar 6.

Department of Pediatrics, Columbia University, New York 10032, USA.

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http://dx.doi.org/10.1038/ncb3485DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5613662PMC
April 2017

Inconsistency in 'three-parent' IVF study.

Authors:
Dieter Egli

Reprod Biomed Online 2017 03 16;34(3):280. Epub 2016 Dec 16.

Department of Obstetrics and Gynecology, Columbia University, New York, NY. Electronic address:

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http://dx.doi.org/10.1016/j.rbmo.2016.12.010DOI Listing
March 2017

Genome Transfer Prevents Fragmentation and Restores Developmental Potential of Developmentally Compromised Postovulatory Aged Mouse Oocytes.

Stem Cell Reports 2017 03 24;8(3):576-588. Epub 2017 Feb 24.

The New York Stem Cell Foundation Research Institute, New York, NY 10032, USA; Department of Pediatrics, Naomi Berrie Diabetes Center, Columbia University, New York, NY 10032, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2017.01.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355644PMC
March 2017

PC1/3 Deficiency Impacts Pro-opiomelanocortin Processing in Human Embryonic Stem Cell-Derived Hypothalamic Neurons.

Stem Cell Reports 2017 02 26;8(2):264-277. Epub 2017 Jan 26.

Division of Molecular Genetics, Department of Pediatrics and Naomi Berrie Diabetes Center, College of Physicians and Surgeons, Columbia University, 1150 St. Nicholas Avenue, Room 620A, New York, NY 10032, USA; Department of Medicine and Naomi Berrie Diabetes Center, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2016.12.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312251PMC
February 2017

Identification and propagation of haploid human pluripotent stem cells.

Nat Protoc 2016 Nov 20;11(11):2274-2286. Epub 2016 Oct 20.

The Azrieli Center for Stem Cells and Genetic Research, Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem, Israel.

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http://dx.doi.org/10.1038/nprot.2016.145DOI Listing
November 2016

Induced pluripotent stem cells (iPSC) created from skin fibroblasts of patients with Prader-Willi syndrome (PWS) retain the molecular signature of PWS.

Stem Cell Res 2016 11 16;17(3):526-530. Epub 2016 Aug 16.

Columbia University, Department of Pediatrics, Division of Molecular Genetics, United States; Naomi Berrie Diabetes Center, United States; New York Obesity Research Center, United States. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2016.08.008DOI Listing
November 2016

Efficient Generation of Hypothalamic Neurons from Human Pluripotent Stem Cells.

Curr Protoc Hum Genet 2016 07 1;90:21.5.1-21.5.14. Epub 2016 Jul 1.

Naomi Berrie Diabetes Center, Columbia University College of Physicians and Surgeons, New York, New York.

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http://dx.doi.org/10.1002/cphg.3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963463PMC
July 2016

Analysis of chromosomal aberrations and recombination by allelic bias in RNA-Seq.

Nat Commun 2016 07 7;7:12144. Epub 2016 Jul 7.

The Azrieli Center for Stem Cells and Genetic Research, Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem 91904, Israel.

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http://dx.doi.org/10.1038/ncomms12144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941052PMC
July 2016

Genetic Drift Can Compromise Mitochondrial Replacement by Nuclear Transfer in Human Oocytes.

Cell Stem Cell 2016 06 19;18(6):749-54. Epub 2016 May 19.

The New York Stem Cell Foundation Research Institute, New York, NY 10032, USA; Naomi Berrie Diabetes Center, Columbia University, Department of Pediatrics, New York, NY 10032, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2016.04.001DOI Listing
June 2016

Derivation and differentiation of haploid human embryonic stem cells.

Nature 2016 Apr 16;532(7597):107-11. Epub 2016 Mar 16.

The Azrieli Center for Stem Cells and Genetic Research, Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem 91904, Israel.

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http://dx.doi.org/10.1038/nature17408DOI Listing
April 2016

Human embryos commonly form abnormal nuclei during development: a mechanism of DNA damage, embryonic aneuploidy, and developmental arrest.

Hum Reprod 2016 Feb 29;31(2):312-23. Epub 2015 Nov 29.

Department of Pediatrics, Columbia University of Physicians and Surgeons, 1150 St. Nicholas Avenue, New York, NY 10032, USA The New York Stem Cell Foundation Research Institute, New York, NY 10032, USA

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http://dx.doi.org/10.1093/humrep/dev281DOI Listing
February 2016

GFP-specific CD8 T cells enable targeted cell depletion and visualization of T-cell interactions.

Nat Biotechnol 2015 Dec 2;33(12):1287-1292. Epub 2015 Nov 2.

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

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http://dx.doi.org/10.1038/nbt.3386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675673PMC
December 2015

From cloned frogs to patient matched stem cells: induced pluripotency or somatic cell nuclear transfer?

Curr Opin Genet Dev 2015 Oct 15;34:29-34. Epub 2015 Aug 15.

The New York Stem Cell Foundation Research Institute, New York, NY 10032, USA; Naomi Berrie Diabetes Center, Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.gde.2015.06.007DOI Listing
October 2015

Toward beta cell replacement for diabetes.

EMBO J 2015 Apr 1;34(7):841-55. Epub 2015 Mar 1.

The New York Stem Cell Foundation Research Institute, New York, NY, USA Naomi Berrie Diabetes Center & Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, NY, USA

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http://emboj.embopress.org/cgi/doi/10.15252/embj.201490685
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http://dx.doi.org/10.15252/embj.201490685DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388595PMC
April 2015

Stem Cell-Derived Beta Cells for Treatment of Type 1 Diabetes?

EBioMedicine 2014 Dec 29;1(2-3):93-4. Epub 2014 Oct 29.

Naomi Berrie Diabetes Center, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA ; Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA ; The New York Stem Cell Foundation Research Institute (NYSCF), New York, NY 10032, USA.

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http://dx.doi.org/10.1016/j.ebiom.2014.10.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457409PMC
December 2014

Comparable frequencies of coding mutations and loss of imprinting in human pluripotent cells derived by nuclear transfer and defined factors.

Cell Stem Cell 2014 Nov 6;15(5):634-42. Epub 2014 Nov 6.

The New York Stem Cell Foundation Research Institute, New York, NY 10032, USA; Naomi Berrie Diabetes Center & Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2014.10.002DOI Listing
November 2014

Gene therapy in patient-specific stem cell lines and a preclinical model of retinitis pigmentosa with membrane frizzled-related protein defects.

Mol Ther 2014 Sep 4;22(9):1688-97. Epub 2014 Jun 4.

1] New York-Presbyterian Hospital/Columbia University Medical Center, New York, New York, USA [2] Department of Pathology and Cell Biology, Columbia University, New York, New York, USA.

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http://dx.doi.org/10.1038/mt.2014.100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4435479PMC
September 2014

Validation of genome-wide association study (GWAS)-identified disease risk alleles with patient-specific stem cell lines.

Hum Mol Genet 2014 Jul 4;23(13):3445-55. Epub 2014 Feb 4.

Barbara and Donald Jonas Laboratory of Stem Cells and Regenerative Medicine, Department of Ophthalmology, Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA, Edward S. Harkness Eye Institute, Columbia University, New York, NY 10032, USA, New York-Presbyterian Hospital, Columbia University Medical Center, New York, NY 10032, USA

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http://dx.doi.org/10.1093/hmg/ddu053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049304PMC
July 2014

FOXO1 inhibition yields functional insulin-producing cells in human gut organoid cultures.

Nat Commun 2014 Jun 30;5:4242. Epub 2014 Jun 30.

Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA.

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http://dx.doi.org/10.1038/ncomms5242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4083475PMC
June 2014

Hypomorphism for RPGRIP1L, a ciliary gene vicinal to the FTO locus, causes increased adiposity in mice.

Cell Metab 2014 May;19(5):767-79

Naomi Berrie Diabetes Center and Division of Molecular Genetics, Department of Pediatrics, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2014.04.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131684PMC
May 2014

Harnessing the stem cell potential: the path to prevent mitochondrial disease.

Nat Med 2013 Dec;19(12):1578-9

Department of Genetics, Yale University, New Haven, Connecticut, USA.

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http://dx.doi.org/10.1038/nm.3422DOI Listing
December 2013

Mouse BAZ1A (ACF1) is dispensable for double-strand break repair but is essential for averting improper gene expression during spermatogenesis.

PLoS Genet 2013 Nov 7;9(11):e1003945. Epub 2013 Nov 7.

Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, New York, New York, United States of America ; Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America ; Howard Hughes Medical Institute, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1003945DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820798PMC
November 2013

Connecting the cell cycle with cellular identity.

Cell Reprogram 2013 Oct;15(5):356-66

1 Department of Pediatrics, Naomi Berric Diabetes Center, Columbia University , New York, NY 10032.

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http://www.liebertpub.com/doi/10.1089/cell.2013.0041
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http://dx.doi.org/10.1089/cell.2013.0041DOI Listing
October 2013

Tying replication to cell identity.

Nat Rev Mol Cell Biol 2013 Jun;14(6):326

The New York Stem Cell Foundation, New York, USA.

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http://dx.doi.org/10.1038/nrm3593DOI Listing
June 2013

Mouse ooplasm confers context-specific reprogramming capacity.

Nat Genet 2012 Sep 19;44(9):978-80. Epub 2012 Aug 19.

Broad Institute of MIT, Cambridge, Massachusetts, USA.

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http://www.nature.com/articles/ng.2382
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http://dx.doi.org/10.1038/ng.2382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432711PMC
September 2012

Recipient cell nuclear factors are required for reprogramming by nuclear transfer.

Development 2010 Jun 12;137(12):1953-63. Epub 2010 May 12.

The Howard Hughes Medical Institute, Stowers Medical Institute, Harvard Stem Cell Institute and Department of Stem Cell and Regenerative Biology, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA.

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http://dev.biologists.org/cgi/doi/10.1242/dev.046151
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http://dx.doi.org/10.1242/dev.046151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2875839PMC
June 2010

Breaking ground on translational stem cell research.

Ann N Y Acad Sci 2010 Mar;1189 Suppl 1:E1-15

The New York Stem Cell Foundation, 163 Amsterdam Avenue, New York, NY 10023, USA.

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http://dx.doi.org/10.1111/j.1749-6632.2010.05495.xDOI Listing
March 2010

Digital RNA allelotyping reveals tissue-specific and allele-specific gene expression in human.

Nat Methods 2009 Aug 20;6(8):613-8. Epub 2009 Jul 20.

Department of Bioengineering, University of California at San Diego, La Jolla, California, USA.

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http://dx.doi.org/10.1038/nmeth.1357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742772PMC
August 2009

Reprogramming after chromosome transfer into mouse blastomeres.

Curr Biol 2009 Aug 13;19(16):1403-9. Epub 2009 Aug 13.

Stowers Medical Institute, Harvard Stem Cell Institute, Department of Stem Cell and Regenerative Biology, Harvard University, 7 Divinity Avenue, Cambridge, MA 02140, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S096098220901403
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http://dx.doi.org/10.1016/j.cub.2009.06.065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335243PMC
August 2009

Mediators of reprogramming: transcription factors and transitions through mitosis.

Nat Rev Mol Cell Biol 2008 Jul;9(7):505-16

The Stowers Medical Institute, Harvard Stem Cell Institute and the Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, USA.

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http://www.nature.com/articles/nrm2439
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http://dx.doi.org/10.1038/nrm2439DOI Listing
July 2008

CAF-1 is essential for Drosophila development and involved in the maintenance of epigenetic memory.

Dev Biol 2007 Nov 29;311(1):213-22. Epub 2007 Aug 29.

National Laboratory of Biomacromolecules and State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, The Chinese Academy of Sciences, Datun Road 15, Chaoyang District, Beijing 100101, China.

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http://dx.doi.org/10.1016/j.ydbio.2007.08.039DOI Listing
November 2007

Developmental reprogramming after chromosome transfer into mitotic mouse zygotes.

Nature 2007 Jun;447(7145):679-85

The Stowers Medical Institute, Harvard Stem Cell Institute and Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA.

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http://dx.doi.org/10.1038/nature05879DOI Listing
June 2007

In vivo construction of transgenes in Drosophila.

Genetics 2007 Apr 18;175(4):2019-28. Epub 2006 Dec 18.

Institute of Molecular Biology, University of Zurich, Zurich CH-8057, Switzerland.

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http://www.genetics.org/cgi/doi/10.1534/genetics.106.065920
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http://dx.doi.org/10.1534/genetics.106.065920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1855104PMC
April 2007

Nuclear transfer into mouse oocytes.

J Vis Exp 2006 Nov 30(1):116. Epub 2006 Nov 30.

Dept of Molecular and Cellular Biology, Harvard University, USA.

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http://dx.doi.org/10.3791/116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2504452PMC
November 2006

An efficient method to generate chromosomal rearrangements by targeted DNA double-strand breaks in Drosophila melanogaster.

Genome Res 2004 Jul 14;14(7):1382-93. Epub 2004 Jun 14.

Institut für Molekularbiologie, CH-8057 Zürich, Switzerland.

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http://dx.doi.org/10.1101/gr.2279804DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC442155PMC
July 2004

Metal-responsive transcription factor (MTF-1) and heavy metal stress response in Drosophila and mammalian cells: a functional comparison.

Biol Chem 2004 Jul;385(7):597-603

Institute of Molecular Biology, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland.

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http://www.degruyter.com/view/j/bchm.2004.385.issue-7/bc.200
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http://dx.doi.org/10.1515/BC.2004.074DOI Listing
July 2004

Knockout of 'metal-responsive transcription factor' MTF-1 in Drosophila by homologous recombination reveals its central role in heavy metal homeostasis.

EMBO J 2003 Jan;22(1):100-8

Institut für Molekularbiologie and Zoologisches Institut der Universität Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland.

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http://dx.doi.org/10.1093/emboj/cdg012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC140060PMC
January 2003