David R Corey

David R Corey

UNVERIFIED PROFILE

Are you David R Corey?   Register this Author

Register author
David R Corey

David R Corey

Publications by authors named "David R Corey"

Are you David R Corey?   Register this Author

100Publications

934Reads

35Profile Views

The 10th Oligonucleotide Therapy Approved: Golodirsen for Duchenne Muscular Dystrophy.

Nucleic Acid Ther 2020 Feb 11. Epub 2020 Feb 11.

Department of Pharmacology, UT Southwestern Medical Center, Dallas, Texas.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/nat.2020.0845DOI Listing
February 2020

Expression of TNRC6 (GW182) Proteins Is Not Necessary for Gene Silencing by Fully Complementary RNA Duplexes.

Nucleic Acid Ther 2019 Dec 31;29(6):323-334. Epub 2019 Oct 31.

Departments of Pharmacology and Biochemistry, UT Southwestern Medical Center at Dallas, Dallas, Texas.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/nat.2019.0815DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6885777PMC
December 2019

Limits of using oligonucleotides for allele-selective inhibition at trinucleotide repeat sequences - targeting the CAG repeat within ataxin-1.

Nucleosides Nucleotides Nucleic Acids 2019 Oct 24:1-10. Epub 2019 Oct 24.

Departments of Pharmacology and Biochemistry, UT Southwestern Medical Center at Dallas , Dallas , TX , USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/15257770.2019.1671592DOI Listing
October 2019

Quantitative Studies of Muscleblind Proteins and Their Interaction With TCF4 RNA Foci Support Involvement in the Mechanism of Fuchs' Dystrophy.

Invest Ophthalmol Vis Sci 2019 09;60(12):3980-3991

Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, Texas, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1167/iovs.19-27641DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779288PMC
September 2019

Guidelines for Experiments Using Antisense Oligonucleotides and Double-Stranded RNAs.

Nucleic Acid Ther 2019 Jun 23;29(3):116-122. Epub 2019 Mar 23.

3 Departments of Pharmacology and Biochemistry, UT Southwestern Medical Center at Dallas, Dallas, Texas.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/nat.2018.0772DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555184PMC
June 2019

RNA-Mediated Gene Activation: Identifying a Candidate RNA for Preclinical Development.

Authors:
David R Corey

Adv Exp Med Biol 2017;983:161-171

Departments of Pharmacology & Biochemistry, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, Texas, 75390-9041, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-981-10-4310-9_11DOI Listing
April 2019

Duplex RNAs and ss-siRNAs Block RNA Foci Associated with Fuchs' Endothelial Corneal Dystrophy.

Nucleic Acid Ther 2019 Apr 24;29(2):73-81. Epub 2019 Jan 24.

1 Department of Pharmacology and Biochemistry, UT Southwestern Medical Center at Dallas, Dallas, Texas.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/nat.2018.0764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461152PMC
April 2019

Activating frataxin expression by single-stranded siRNAs targeting the GAA repeat expansion.

Bioorg Med Chem Lett 2018 09 21;28(17):2850-2855. Epub 2018 Jul 21.

Department of Pharmacology, UT Southwestern Medical Center at Dallas, Dallas, TX 75390, United States; Department of Biochemistry, UT Southwestern Medical Center at Dallas, Dallas, TX 75390, United States. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2018.07.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6129981PMC
September 2018

The Requirement for GW182 Scaffolding Protein Depends on Whether Argonaute Is Mediating Translation, Transcription, or Splicing.

Biochemistry 2018 09 21;57(35):5247-5256. Epub 2018 Aug 21.

Departments of Pharmacology and Biochemistry , The University of Texas Southwestern Medical Center , Dallas , Texas 75390 , United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.biochem.8b00602DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124307PMC
September 2018

Chemistry, mechanism and clinical status of antisense oligonucleotides and duplex RNAs.

Nucleic Acids Res 2018 02;46(4):1584-1600

Departments of Pharmacology & Biochemistry, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390-9041, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gkx1239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829639PMC
February 2018

Editorial: Nucleic Acids Research and Nucleic Acid Therapeutics.

Nucleic Acids Res 2018 02;46(4):1563-1564

Centre for Biological Sciences, University of Southampton, Life Sciences Building 85, Southampton SO17 1BJ, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gky059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829634PMC
February 2018

Human GW182 Paralogs Are the Central Organizers for RNA-Mediated Control of Transcription.

Cell Rep 2017 08;20(7):1543-1552

Departments of Pharmacology and Biochemistry, UT Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390-9041, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2017.07.058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5588873PMC
August 2017

Recognition of c9orf72 Mutant RNA by Single-Stranded Silencing RNAs.

Nucleic Acid Ther 2017 04 22;27(2):87-94. Epub 2016 Dec 22.

1 Department of Pharmacology, UT Southwestern Medical Center at Dallas , Dallas, Texas.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/nat.2016.0655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372765PMC
April 2017

Nusinersen, an antisense oligonucleotide drug for spinal muscular atrophy.

Authors:
David R Corey

Nat Neurosci 2017 04 13;20(4):497-499. Epub 2017 Feb 13.

Departments of Pharmacology and Biochemistry, UT Southwestern, Dallas, Texas, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nn.4508DOI Listing
April 2017

Non-coding RNAs as drug targets.

Nat Rev Drug Discov 2017 Mar 22;16(3):167-179. Epub 2016 Jul 22.

Departments of Pharmacology and Biochemistry, UT Southwestern, Dallas, Texas 75390-9041, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrd.2016.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831170PMC
March 2017

c9orf72 Disease-Related Foci Are Each Composed of One Mutant Expanded Repeat RNA.

Cell Chem Biol 2017 Feb 26;24(2):141-148. Epub 2017 Jan 26.

Departments of Pharmacology and Biochemistry, UT Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chembiol.2016.12.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316317PMC
February 2017

Doubts About Therapy for Neurological Diseases With Antisense Oligonucleotides-Reply.

Authors:
David R Corey

JAMA Neurol 2016 12;73(12):1502-1503

Departments of Pharmacology and Biochemistry, University of Texas Southwestern, Dallas.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamaneurol.2016.4335DOI Listing
December 2016

Synthetic Nucleic Acids and Treatment of Neurological Diseases.

Authors:
David R Corey

JAMA Neurol 2016 Oct;73(10):1238-1242

Department of Pharmacology, University of Texas Southwestern, Dallas2Department of Biochemistry, University of Texas Southwestern, Dallas.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamaneurol.2016.2089DOI Listing
October 2016

HP1BP3, a Chromatin Retention Factor for Co-transcriptional MicroRNA Processing.

Mol Cell 2016 08 14;63(3):420-32. Epub 2016 Jul 14.

Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; International Institute for Integrated Sleep Medicine, University of Tsukuba, Tsukuba 305-8575, Japan; Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molcel.2016.06.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975613PMC
August 2016

Stable association of RNAi machinery is conserved between the cytoplasm and nucleus of human cells.

RNA 2016 07 19;22(7):1085-98. Epub 2016 May 19.

Department of Pharmacology, Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1261/rna.056499.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911916PMC
July 2016

Argonaute 2-dependent Regulation of Gene Expression by Single-stranded miRNA Mimics.

Mol Ther 2016 05 23;24(5):946-55. Epub 2016 Feb 23.

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/mt.2016.39DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881773PMC
May 2016

Pathogenic C9ORF72 Antisense Repeat RNA Forms a Double Helix with Tandem C:C Mismatches.

Biochemistry 2016 Mar 22;55(9):1283-6. Epub 2016 Feb 22.

Department of Pharmacology, ‡Department of Biophysics, and §Department of Biochemistry, University of Texas Southwestern Medical Center , Dallas, Texas 75390, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.biochem.6b00136DOI Listing
March 2016

Activating frataxin expression by repeat-targeted nucleic acids.

Nat Commun 2016 Feb 4;7:10606. Epub 2016 Feb 4.

Departments of Pharmacology and Biochemistry, UT Southwestern Medical Center at Dallas, 6001 Forest Park Road, Dallas, Texas 75390-9041, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncomms10606DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742999PMC
February 2016

Regulation of mammalian transcription and splicing by Nuclear RNAi.

Nucleic Acids Res 2016 Jan 26;44(2):524-37. Epub 2015 Nov 26.

Departments of Pharmacology & Biochemistry, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390-9041, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gkv1305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737150PMC
January 2016

Stepping toward therapeutic CRISPR.

Proc Natl Acad Sci U S A 2015 Dec 7;112(51):15536-7. Epub 2015 Dec 7.

Departments of Pharmacology and Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390-9041

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1521670112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4697397PMC
December 2015

Engineering Duplex RNAs for Challenging Targets: Recognition of GGGGCC/CCCCGG Repeats at the ALS/FTD C9orf72 Locus.

Chem Biol 2015 Nov 12;22(11):1505-1511. Epub 2015 Nov 12.

Departments of Pharmacology and Biochemistry, UT Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390-9041, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chembiol.2015.09.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4659491PMC
November 2015

Reduced Expression of Argonaute 1, Argonaute 2, and TRBP Changes Levels and Intracellular Distribution of RNAi Factors.

Sci Rep 2015 Aug 5;5:12855. Epub 2015 Aug 5.

Departments of Pharmacology and Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas, 75390-9041.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/srep12855DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4525381PMC
August 2015

Identification and validation of miRNA target sites within nontraditional miRNA targets.

Methods Mol Biol 2015 ;1206:53-67

Departments of Pharmacology and Biochemistry, UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX, 75390-9041, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-1369-5_5DOI Listing
June 2015

Modulation of Splicing by Single-Stranded Silencing RNAs.

Nucleic Acid Ther 2015 Jun 10;25(3):113-20. Epub 2015 Mar 10.

1Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/nat.2014.0527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4440996PMC
June 2015

Intramolecular circularization increases efficiency of RNA sequencing and enables CLIP-Seq of nuclear RNA from human cells.

Nucleic Acids Res 2015 Jun 26;43(11):e75. Epub 2015 Mar 26.

Departments of Pharmacology and Biochemistry, 6001 Forest Park Road, Dallas, TX 75390-9041, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gkv213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477644PMC
June 2015

Design and bioinformatics analysis of genome-wide CLIP experiments.

Nucleic Acids Res 2015 Jun 9;43(11):5263-74. Epub 2015 May 9.

Quantitative Biomedical Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gkv439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477666PMC
June 2015

Analysis of nuclear RNA interference in human cells by subcellular fractionation and Argonaute loading.

Nat Protoc 2014 Sep 31;9(9):2045-60. Epub 2014 Jul 31.

1] Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA. [2] Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nprot.2014.135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4251768PMC
September 2014

Allele-selective inhibition of mutant atrophin-1 expression by duplex and single-stranded RNAs.

Biochemistry 2014 Jul 11;53(28):4510-8. Epub 2014 Jul 11.

Departments of Pharmacology and Biochemistry, University of Texas Southwestern Medical Center , 6001 Forest Park Road, Dallas, Texas 75390-9041, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/bi500610rDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108179PMC
July 2014

RNAi factors are present and active in human cell nuclei.

Cell Rep 2014 Jan 2;6(1):211-21. Epub 2014 Jan 2.

Departments of Pharmacology and Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390-9041, USA. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S22111247130075
Publisher Site
http://dx.doi.org/10.1016/j.celrep.2013.12.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916906PMC
January 2014

Promoter RNA links transcriptional regulation of inflammatory pathway genes.

Nucleic Acids Res 2013 Dec 2;41(22):10086-109. Epub 2013 Sep 2.

Department of Pharmacology and Biochemistry, UT Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390-9041, USA and Alnylam Pharmaceuticals, Cambridge, MA 02142, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gkt777DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905862PMC
December 2013

Allele-selective inhibition of expression of huntingtin and ataxin-3 by RNA duplexes containing unlocked nucleic acid substitutions.

Biochemistry 2013 Dec 27;52(51):9329-38. Epub 2013 Nov 27.

Departments of Pharmacology and Biochemistry, University of Texas Southwestern Medical Center , 6001 Forest Park Road, Dallas, Texas 75390-9041, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/bi4014209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893079PMC
December 2013

ss-siRNAs allele selectively inhibit ataxin-3 expression: multiple mechanisms for an alternative gene silencing strategy.

Nucleic Acids Res 2013 Nov 9;41(20):9570-83. Epub 2013 Aug 9.

Departments of Pharmacology and Biochemistry, UT Southwestern Medical Center at Dallas, Dallas, TX 75390, USA and Department of Medicinal Chemistry and Core Antisense Research, ISIS Pharmaceuticals, Carlsbad, CA 92010, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gkt693DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814390PMC
November 2013

RNA duplexes with abasic substitutions are potent and allele-selective inhibitors of huntingtin and ataxin-3 expression.

Nucleic Acids Res 2013 Oct 24;41(18):8788-801. Epub 2013 Jul 24.

Departments of Pharmacology and Biochemistry, UT Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390-9041, USA, Department of Chemistry and Institute for Life Sciences, University of Southampton, Highfield, Southampton, SO17 1BJ, UK and Alnylam Pharmaceuticals, 300 Third St., Cambridge, MA 02142, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gkt594DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3794577PMC
October 2013

Digital quantitation of potential therapeutic target RNAs.

Nucleic Acid Ther 2013 Jun 8;23(3):188-94. Epub 2013 May 8.

Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/nat.2013.0427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660070PMC
June 2013

Mechanism of allele-selective inhibition of huntingtin expression by duplex RNAs that target CAG repeats: function through the RNAi pathway.

Nucleic Acids Res 2012 Dec 4;40(22):11270-80. Epub 2012 Oct 4.

Departments of Pharmacology and Biochemistry, UT Southwestern Medical Center at Dallas, Dallas, TX 75390-9041, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gks907DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526262PMC
December 2012

RNA sequencing: platform selection, experimental design, and data interpretation.

Nucleic Acid Ther 2012 Aug 25;22(4):271-4. Epub 2012 Jul 25.

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/nat.2012.0367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3426205PMC
August 2012

Single-stranded RNAs use RNAi to potently and allele-selectively inhibit mutant huntingtin expression.

Cell 2012 Aug;150(5):895-908

Departments of Pharmacology and Biochemistry, UT Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390-9041, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cell.2012.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3444165PMC
August 2012

Transcriptional silencing by hairpin RNAs complementary to a gene promoter.

Nucleic Acid Ther 2012 Jun;22(3):147-51

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

View Article

Download full-text PDF

Source
http://www.liebertpub.com/doi/10.1089/nat.2012.0360
Publisher Site
http://dx.doi.org/10.1089/nat.2012.0360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871491PMC
June 2012

Allele-selective inhibition of trinucleotide repeat genes.

Drug Discov Today 2012 May 18;17(9-10):443-50. Epub 2012 Jan 18.

Departments of Pharmacology and Biochemistry, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390-9041, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.drudis.2012.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3468950PMC
May 2012

Expanding the action of duplex RNAs into the nucleus: redirecting alternative splicing.

Nucleic Acids Res 2012 Feb 23;40(3):1240-50. Epub 2011 Sep 23.

Department of Pharmacology, UT Southwestern Medical Center at Dallas, Dallas, TX 75390-9041, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gkr780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3273794PMC
February 2012

Argonaute and the nuclear RNAs: new pathways for RNA-mediated control of gene expression.

Nucleic Acid Ther 2012 Feb 27;22(1):3-16. Epub 2012 Jan 27.

Departments of Pharmacology and Biochemistry, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/nat.2011.0330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3318256PMC
February 2012

Silencing disease genes in the laboratory and the clinic.

J Pathol 2012 Jan 9;226(2):365-79. Epub 2011 Nov 9.

Departments of Pharmacology and Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390-9041, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/path.2993DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916955PMC
January 2012

Practical considerations for analyzing antigene RNAs (agRNAs): RNA immunoprecipitation of argonaute protein.

Methods Mol Biol 2011 ;764:301-15

Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-61779-188-8_20DOI Listing
October 2011

Clonal Rett Syndrome cell lines to test compounds for activation of wild-type MeCP2 expression.

Bioorg Med Chem Lett 2011 Sep 23;21(18):5202-5. Epub 2011 Jul 23.

Department of Pharmacology, UT Southwestern Medical Center at Dallas, Dallas, 6001 Forest Park Road, TX 75390, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2011.07.053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159815PMC
September 2011

Transcriptional regulation by miRNA mimics that target sequences downstream of gene termini.

Mol Biosyst 2011 Aug 18;7(8):2383-8. Epub 2011 May 18.

Departments of Pharmacology and Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390-9041, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/c1mb05090gDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4668949PMC
August 2011

Transcriptional gene silencing in mammalian cells by miRNA mimics that target gene promoters.

Nucleic Acids Res 2011 Jul 22;39(13):5682-91. Epub 2011 Mar 22.

Department of Pharmacology and Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390-9041, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gkr155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141263PMC
July 2011

Regulation of TFEB and V-ATPases by mTORC1.

EMBO J 2011 Jul 29;30(16):3242-58. Epub 2011 Jul 29.

Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.

View Article

Download full-text PDF

Source
http://emboj.embopress.org/cgi/doi/10.1038/emboj.2011.257
Publisher Site
http://dx.doi.org/10.1038/emboj.2011.257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160667PMC
July 2011

Antisense and antigene inhibition of gene expression by cell-permeable oligonucleotide-oligospermine conjugates.

J Am Chem Soc 2011 Jun 12;133(22):8404-7. Epub 2011 May 12.

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/ja200312yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3106116PMC
June 2011

Allele-selective inhibition of ataxin-3 (ATX3) expression by antisense oligomers and duplex RNAs.

Biol Chem 2011 Apr 7;392(4):315-25. Epub 2011 Feb 7.

Departments of Pharmacology and Biochemistry, UT Southwestern Medical Center, Dallas, TX 75390-9041, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1515/BC.2011.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3908450PMC
April 2011

Minireview: Switching on progesterone receptor expression with duplex RNA.

Mol Endocrinol 2010 Dec 30;24(12):2243-52. Epub 2010 Jun 30.

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75205, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/me.2010-0067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2999478PMC
December 2010

Activation of LDL receptor expression by small RNAs complementary to a noncoding transcript that overlaps the LDLR promoter.

Chem Biol 2010 Dec;17(12):1344-55

Departments of Pharmacology and Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390-9041, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chembiol.2010.10.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3071588PMC
December 2010

Involvement of argonaute proteins in gene silencing and activation by RNAs complementary to a non-coding transcript at the progesterone receptor promoter.

Nucleic Acids Res 2010 Nov 30;38(21):7736-48. Epub 2010 Jul 30.

Department of Pharmacology and Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390-9041, USA.

View Article

Download full-text PDF

Source
https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/
Publisher Site
http://dx.doi.org/10.1093/nar/gkq648DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995069PMC
November 2010

Allele-selective inhibition of huntingtin expression by switching to an miRNA-like RNAi mechanism.

Chem Biol 2010 Nov;17(11):1183-8

The Departments of Pharmacology and Biochemistry, UT Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390-9041, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chembiol.2010.10.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021381PMC
November 2010

Transcriptional regulation by small RNAs at sequences downstream from 3' gene termini.

Nat Chem Biol 2010 Aug 27;6(8):621-9. Epub 2010 Jun 27.

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nchembio.400DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909968PMC
August 2010

Clinical status of duplex RNA.

Bioorg Med Chem Lett 2010 Jun 2;20(11):3203-7. Epub 2010 Apr 2.

Departments of Pharmacology and Biochemistry, UT Southwestern Medical Center at Dallas, 6001 Forest Park Road, Dallas, TX 75390, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2010.03.109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874620PMC
June 2010

Telomeres and telomerase: from discovery to clinical trials.

Authors:
David R Corey

Chem Biol 2009 Dec;16(12):1219-23

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9041, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chembiol.2009.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2810624PMC
December 2009

Cellular localization and allele-selective inhibition of mutant huntingtin protein by peptide nucleic acid oligomers containing the fluorescent nucleobase [bis-o-(aminoethoxy)phenyl]pyrrolocytosine.

Bioorg Med Chem Lett 2009 Nov 6;19(21):6181-4. Epub 2009 Sep 6.

Department of Pharmacology, UT Southwestern Medical Center at Dallas, Dallas, 6001 Forest Park Road, TX 75390, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2009.09.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2770837PMC
November 2009

Allele-selective inhibition of mutant huntingtin by peptide nucleic acid-peptide conjugates, locked nucleic acid, and small interfering RNA.

Ann N Y Acad Sci 2009 Sep;1175:24-31

Department of Pharmacology and Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-9041, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1749-6632.2009.04975.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3908448PMC
September 2009

Predicting potential miRNA target sites within gene promoters.

Bioorg Med Chem Lett 2009 Jul 18;19(14):3791-4. Epub 2009 Apr 18.

Departments of Pharmacology and Biochemistry, UT Southwestern Medical Center at Dallas, Dallas, TX 75390, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2009.04.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2709707PMC
July 2009

The puzzle of RNAs that target gene promoters.

Chembiochem 2009 May;10(7):1135-9

Department of Pharmacology, UT Southwestern Medical Center, Dallas, TX 75390-9041, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbic.200900015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2759896PMC
May 2009

Allele-specific silencing of mutant huntingtin and ataxin-3 genes by targeting expanded CAG repeats in mRNAs.

Nat Biotechnol 2009 May 3;27(5):478-84. Epub 2009 May 3.

Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nbt.1539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765218PMC
May 2009

Recognition of chromosomal DNA inside cells by locked nucleic acids.

Biochemistry 2008 Dec;47(50):13147-9

Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, 6001 Forest Park Road, Dallas, Texas 75390-9041, USA.

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/abs/10.1021/bi801930p
Publisher Site
http://dx.doi.org/10.1021/bi801930pDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2627484PMC
December 2008

Antisense transcripts are targets for activating small RNAs.

Nat Struct Mol Biol 2008 Aug 6;15(8):842-8. Epub 2008 Jul 6.

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9041, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nsmb.1444DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2574822PMC
August 2008

Chemical modification: the key to clinical application of RNA interference?

Authors:
David R Corey

J Clin Invest 2007 Dec;117(12):3615-22

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9041, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1172/JCI33483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2096450PMC
December 2007

Inhibiting transcription of chromosomal DNA using antigene RNAs.

Nucleic Acids Symp Ser (Oxf) 2005 (49):367-8

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9041, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nass/49.1.367DOI Listing
June 2007

Silencing gene expression by targeting chromosomal DNA with antigene peptide nucleic acids and duplex RNAs.

Nat Protoc 2006 ;1(1):436-43

Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-9041, USA.

View Article

Download full-text PDF

Source
http://www.nature.com/doifinder/10.1038/nprot.2006.64
Publisher Site
http://dx.doi.org/10.1038/nprot.2006.64DOI Listing
June 2007

Inhibiting gene expression with locked nucleic acids (LNAs) that target chromosomal DNA.

Biochemistry 2007 Jun 31;46(25):7572-80. Epub 2007 May 31.

Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, 6001 Forest Park Road, Dallas, Texas 75390-9041, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/bi700227gDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2527755PMC
June 2007

Inhibiting gene expression with peptide nucleic acid (PNA)--peptide conjugates that target chromosomal DNA.

Biochemistry 2007 Jun 31;46(25):7581-9. Epub 2007 May 31.

Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, 6001 Forest Park Road, Dallas, Texas 75390-9041, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/bi700230aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2564818PMC
June 2007

Activating gene expression in mammalian cells with promoter-targeted duplex RNAs.

Nat Chem Biol 2007 Mar 28;3(3):166-73. Epub 2007 Jan 28.

Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/nchembio860
Publisher Site
http://dx.doi.org/10.1038/nchembio860DOI Listing
March 2007

RNA learns from antisense.

Authors:
David R Corey

Nat Chem Biol 2007 Jan;3(1):8-11

Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd., Dallas, Texas 75390-9041, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nchembio0107-8DOI Listing
January 2007

Progesterone receptor plays a major antiinflammatory role in human myometrial cells by antagonism of nuclear factor-kappaB activation of cyclooxygenase 2 expression.

Mol Endocrinol 2006 Nov 13;20(11):2724-33. Epub 2006 Jun 13.

Department of Biochemistry, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9038, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/me.2006-0112DOI Listing
November 2006

Involvement of AGO1 and AGO2 in mammalian transcriptional silencing.

Nat Struct Mol Biol 2006 Sep 27;13(9):787-92. Epub 2006 Aug 27.

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9041, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nsmb1140DOI Listing
September 2006

EuroTIDES 2005--Sixth Annual IBC Conference. Oligonucleotide, RNAi and peptides for the drug development and manufacturing industry.

Authors:
David R Corey

IDrugs 2006 Feb;9(2):105-6

University of Texas Southwestern Medical Center, Department of Pharmacology and Biochemistry, 5323 Harry Hines Boulevard, TX 75390, USA.

View Article

Download full-text PDF

Source
February 2006

Regulating mammalian transcription with RNA.

Authors:
David R Corey

Trends Biochem Sci 2005 Dec 13;30(12):655-8. Epub 2005 Oct 13.

Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-9041, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tibs.2005.09.007DOI Listing
December 2005

Recognition of chromosomal DNA in human cells by peptide nucleic acids and small duplex RNAs.

Authors:
David R Corey

Ann N Y Acad Sci 2005 Nov;1058:16-25

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9041, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1196/annals.1359.003DOI Listing
November 2005

Inhibiting transcription of chromosomal DNA with antigene peptide nucleic acids.

Nat Chem Biol 2005 Sep 31;1(4):210-5. Epub 2005 Jul 31.

Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nchembio724DOI Listing
September 2005

Inhibiting gene expression at transcription start sites in chromosomal DNA with antigene RNAs.

Nat Chem Biol 2005 Sep 31;1(4):216-22. Epub 2005 Jul 31.

Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nchembio725DOI Listing
September 2005

Calcium liberates PNAs from endosomes.

Authors:
David R Corey

Chem Biol 2005 Aug;12(8):864-5

Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chembiol.2005.08.003DOI Listing
August 2005

Telomerase reverse transcriptase (hTERT) mRNA and telomerase RNA (hTR) as targets for downregulation of telomerase activity.

Oligonucleotides 2004 ;14(4):263-73

Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-9041, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/oli.2004.14.263DOI Listing
May 2005

Major vault protein does not play a role in chemoresistance or drug localization in a non-small cell lung cancer cell line.

Biochemistry 2005 Feb;44(7):2253-61

Department of Pharmacology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9041, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/bi047948gDOI Listing
February 2005

Synthesis and purification of peptide nucleic acids.

Curr Protoc Nucleic Acid Chem 2002 Aug;Chapter 4:Unit 4.11

University of Texas Southwestern Medical Center at Dallas, Dallas, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/0471142700.nc0411s09DOI Listing
August 2002

Cellular delivery of locked nucleic acids (LNAs).

Curr Protoc Nucleic Acid Chem 2002 Aug;Chapter 4:Unit 4.13

University of Texas Southwestern Medical Center at Dallas, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/0471142700.nc0413s09DOI Listing
August 2002