David A Ostrov

David A Ostrov

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David A Ostrov

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Molecular docking predictions of fragrance binding to human leukocyte antigen molecules.

Contact Dermatitis 2019 Sep 9;81(3):174-183. Epub 2019 Jul 9.

Division of Cosmetics, Office of Cosmetics and Colors, CFSAN, FDA, College Park, Maryland.

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http://dx.doi.org/10.1111/cod.13283DOI Listing
September 2019

Dapsone- and nitroso dapsone-specific activation of T cells from hypersensitive patients expressing the risk allele HLA-B*13:01.

Allergy 2019 Aug 15;74(8):1533-1548. Epub 2019 Apr 15.

MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, The University of Liverpool, Liverpool, UK.

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http://dx.doi.org/10.1111/all.13769DOI Listing
August 2019

HLA-A*32:01 is strongly associated with vancomycin-induced drug reaction with eosinophilia and systemic symptoms.

J Allergy Clin Immunol 2019 Jul 16;144(1):183-192. Epub 2019 Feb 16.

Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tenn; Institute for Immunology and Infectious Diseases, Murdoch University, Murdoch, Australia; Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tenn; Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tenn. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00916749193021
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http://dx.doi.org/10.1016/j.jaci.2019.01.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612297PMC
July 2019

Targeting the site encoded by SERPINA1*E342K for treating alpha-1 antitrypsin deficiency-associated liver diseases.

FEBS Lett 2019 Jul 6;593(14):1849-1862. Epub 2019 Jun 6.

Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL, USA.

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http://dx.doi.org/10.1002/1873-3468.13452DOI Listing
July 2019

Rationally designed small molecules to prevent type 1 diabetes.

Curr Opin Endocrinol Diabetes Obes 2019 Apr;26(2):90-95

Departments of Pediatrics and Medicine, Barbara Davis Center for Diabetes, University of Colorado School of Medicine, Aurora, Colorado, USA.

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http://dx.doi.org/10.1097/MED.0000000000000470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764771PMC
April 2019

Human Leukocyte Antigen Associations in Drug Hypersensitivity Reactions.

Clin Lab Med 2018 12;38(4):669-677

Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, University of Florida, PO Box 103633, Gainesville, FL 32610-3633, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S02722712183118
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http://dx.doi.org/10.1016/j.cll.2018.08.002DOI Listing
December 2018

Structural Elements Recognized by Abacavir-Induced T Cells.

Int J Mol Sci 2017 Jul 7;18(7). Epub 2017 Jul 7.

Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL 32610, USA.

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http://dx.doi.org/10.3390/ijms18071464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535955PMC
July 2017

Association of the HLA-B*53:01 Allele With Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) Syndrome During Treatment of HIV Infection With Raltegravir.

Clin Infect Dis 2017 05;64(9):1198-1203

Department of Pharmacology, Oates Institute for Experimental Therapeutics, Vanderbilt University Medical School, Nashville, Tennessee, USA.

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http://dx.doi.org/10.1093/cid/cix096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399947PMC
May 2017

Sulfatide Preserves Insulin Crystals Not by Being Integrated in the Lattice but by Stabilizing Their Surface.

J Diabetes Res 2016 14;2016:6179635. Epub 2016 Feb 14.

Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, 1600 SW Archer Road, Gainesville, FL 32610, USA.

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http://dx.doi.org/10.1155/2016/6179635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769769PMC
December 2016

Identification of a Small Molecule Inhibitor of RAD52 by Structure-Based Selection.

PLoS One 2016 19;11(1):e0147230. Epub 2016 Jan 19.

Department of Microbiology and Immunology and Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0147230PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718542PMC
August 2016

Abacavir-reactive memory T cells are present in drug naïve individuals.

PLoS One 2015 12;10(2):e0117160. Epub 2015 Feb 12.

Institute for Immunology and Infectious Diseases, Murdoch University, Perth, Australia; Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0117160PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326126PMC
November 2015

Effects of type 1 diabetes-associated IFIH1 polymorphisms on MDA5 function and expression.

Curr Diab Rep 2015 Nov;15(11):96

Department of Pathology, Immunology and Laboratory Medicine, University of Florida, 2033 Mowry Rd., P.O. Box 103633, Gainesville, FL, 32611, USA.

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http://dx.doi.org/10.1007/s11892-015-0656-8DOI Listing
November 2015

New genetic findings lead the way to a better understanding of fundamental mechanisms of drug hypersensitivity.

J Allergy Clin Immunol 2015 Aug;136(2):236-44

Department of Molecular and Clinical Pharmacology, MRC Centre for Drug Safety Science, University of Liverpool, Liverpool, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2015.06.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534769PMC
August 2015

New approaches for predicting T cell-mediated drug reactions: A role for inducible and potentially preventable autoimmunity.

J Allergy Clin Immunol 2015 Aug;136(2):252-7

Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, Fla. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00916749150087
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http://dx.doi.org/10.1016/j.jaci.2015.06.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529959PMC
August 2015

Development of novel Asf1-H3/H4 inhibitors.

Bioorg Med Chem Lett 2015 Feb 4;25(4):963-8. Epub 2014 Dec 4.

Department of Pharmacology and the Program in Structural Biology and Biochemistry, University of Colorado School of Medicine, Aurora, CO 80045, USA.

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http://dx.doi.org/10.1016/j.bmcl.2014.11.067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437580PMC
February 2015

HLA-DRA variants predict penicillin allergy in genome-wide fine-mapping genotyping.

J Allergy Clin Immunol 2015 Jan 12;135(1):253-9. Epub 2014 Sep 12.

Inserm U-954, Faculté de Médecine, University of Lorraine and University Hospital Center (CHU) of Nancy, Nancy, France; Allergy Service, Carlos Haya Hospital (IBIMA-Hospital Regional Universitario de Malaga), Malaga, Spain.

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http://dx.doi.org/10.1016/j.jaci.2014.07.047DOI Listing
January 2015

Small molecule inhibitor YM155-mediated activation of death receptor 5 is crucial for chemotherapy-induced apoptosis in pancreatic carcinoma.

Mol Cancer Ther 2015 Jan 24;14(1):80-9. Epub 2014 Oct 24.

Department of Pathology, Immunology, and Laboratory Medicine, University of Florida College of Medicine, Gainesville, Florida.

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http://dx.doi.org/10.1158/1535-7163.MCT-14-0229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387779PMC
January 2015

Defective hydrophobic sliding mechanism and active site expansion in HIV-1 protease drug resistant variant Gly48Thr/Leu89Met: mechanisms for the loss of saquinavir binding potency.

Biochemistry 2015 Jan 7;54(2):422-33. Epub 2015 Jan 7.

Department of Biochemistry and Molecular Biology, ‡Department of Chemistry, and §Departments of Pathology, Immunology, and Laboratory Medicine, University of Florida , Gainesville, Florida 32601-0245, United States.

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http://dx.doi.org/10.1021/bi501088eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303317PMC
January 2015

Discovery of structure-based small molecular inhibitor of αB-crystallin against basal-like/triple-negative breast cancer development in vitro and in vivo.

Breast Cancer Res Treat 2014 May 8;145(1):45-59. Epub 2014 Apr 8.

Department of Anatomy and Cell Biology, University of Florida, 1600 SW Archer Road, Gainesville, FL, USA.

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http://dx.doi.org/10.1007/s10549-014-2940-8DOI Listing
May 2014

Gabapentin hybrid peptides and bioconjugates.

Bioorg Med Chem 2014 Feb 12;22(4):1479-86. Epub 2013 Dec 12.

Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA; Chemistry Department, King Abdulaziz University, Jeddah 21589, Saudi Arabia. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2013.12.017DOI Listing
February 2014

Identification of adenine nucleotide translocase 4 inhibitors by molecular docking.

J Mol Graph Model 2013 Sep 4;45:173-9. Epub 2013 Sep 4.

Department of Pathology, University of Florida College of Medicine, Gainesville, FL, USA.

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http://dx.doi.org/10.1016/j.jmgm.2013.08.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3821932PMC
September 2013

Kinetic characterization of newly discovered inhibitors of various constructs of human T-cell leukemia virus-1 (HTLV-1) protease and their effect on HTLV-1-infected cells.

Antivir Ther 2012 21;17(5):883-92. Epub 2012 Mar 21.

University of Florida College of Medicine Biochemistry and Molecular Biology, Gainesville, FL, USA.

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http://dx.doi.org/10.3851/IMP2090DOI Listing
January 2013

The structural basis of HLA-associated drug hypersensitivity syndromes.

Immunol Rev 2012 Nov;250(1):158-66

Department of Chemistry, University of Florida, Gainesville, USA.

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http://dx.doi.org/10.1111/j.1600-065X.2012.01163.xDOI Listing
November 2012

Immunology. A decorated virus cannot hide.

Science 2012 Nov;338(6108):748-9

Department of Pediatrics University of Florida, Gainesville, FL 32610, USA. rherzog@ufl .edu

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http://dx.doi.org/10.1126/science.1230342DOI Listing
November 2012

Human polymorphisms in the glutathione transferase zeta 1/maleylacetoacetate isomerase gene influence the toxicokinetics of dichloroacetate.

J Clin Pharmacol 2012 Jun 3;52(6):837-49. Epub 2011 Jun 3.

Department of Medicine, Division of Endocrinology and Metabolism, College of Medicine, University of Florida, Gainesville, FL 32610, USA.

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http://dx.doi.org/10.1177/0091270011405664DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3786668PMC
June 2012

Genomic and functional characterization of the diverse immunoglobulin domain-containing protein (DICP) family.

Genomics 2012 May 21;99(5):282-91. Epub 2012 Feb 21.

Department of Pediatrics, University of South Florida College of Medicine, USF/ACH Children's Research Institute, 140 7th Avenue South, St. Petersburg, FL 33701, USA.

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http://dx.doi.org/10.1016/j.ygeno.2012.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3351558PMC
May 2012

Enoxacin directly inhibits osteoclastogenesis without inducing apoptosis.

J Biol Chem 2012 May 2;287(21):17894-904. Epub 2012 Apr 2.

Department of Orthodontics, University of Florida College of Dentistry, Gainesville, Florida 32610, USA.

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http://dx.doi.org/10.1074/jbc.M111.280511DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366803PMC
May 2012

Characterization of the 8-hydroxyquinoline scaffold for inhibitors of West Nile virus serine protease.

Antiviral Res 2012 Apr 11;94(1):18-24. Epub 2012 Feb 11.

Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, DC 20057, USA.

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http://dx.doi.org/10.1016/j.antiviral.2012.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3331929PMC
April 2012

Rational identification of enoxacin as a novel V-ATPase-directed osteoclast inhibitor.

Curr Protein Pept Sci 2012 Mar;13(2):180-91

Department of Orthodontics, University of Florida College of Dentistry, Gainesville, FL 32610, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3409362PMC
March 2012

Structure-based selection of small molecules to alter allele-specific MHC class II antigen presentation.

J Immunol 2011 Dec 31;187(11):5921-30. Epub 2011 Oct 31.

Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA.

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http://dx.doi.org/10.4049/jimmunol.1100746DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3221928PMC
December 2011

Molecular imaging of inflammation and carcinogenesis.

Cancer Prev Res (Phila) 2011 Oct;4(10):1523-6

Department of Pediatrics, University of Florida College of Medicine, Gainesville, USA.

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http://dx.doi.org/10.1158/1940-6207.CAPR-11-0418DOI Listing
October 2011

A novel small molecule inhibitor of FAK and IGF-1R protein interactions decreases growth of human esophageal carcinoma.

Anticancer Agents Med Chem 2011 Sep;11(7):629-37

Department of Surgery, University of Florida College of Medicine, Gainesville, FL 32610, USA.

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September 2011

Prediction of off-target effects on angiotensin-converting enzyme 2.

J Biomol Screen 2011 Sep 22;16(8):878-85. Epub 2011 Aug 22.

Department of Chemistry, University of Florida, Gainesville, FL 32611, USA.

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http://journals.sagepub.com/doi/10.1177/1087057111413919
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http://dx.doi.org/10.1177/1087057111413919DOI Listing
September 2011

Functional expression of human adenine nucleotide translocase 4 in Saccharomyces cerevisiae.

PLoS One 2011 Apr 21;6(4):e19250. Epub 2011 Apr 21.

Department of Pathology, College of Medicine, University of Florida, Gainesville, Florida, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0019250PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080916PMC
April 2011

Crystallization and preliminary X-ray analysis of the human long myosin light-chain kinase 1-specific domain IgCAM3.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2011 Feb 22;67(Pt 2):221-3. Epub 2011 Jan 22.

Department of Pathology, University of Chicago, Chicago, IL 60637, USA.

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http://scripts.iucr.org/cgi-bin/paper?S1744309110050323
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http://dx.doi.org/10.1107/S1744309110050323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3034612PMC
February 2011

DNA polymerase β as a novel target for chemotherapeutic intervention of colorectal cancer.

PLoS One 2011 Feb 2;6(2):e16691. Epub 2011 Feb 2.

Department of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, Florida, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0016691PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3032781PMC
February 2011

Recognition of additional roles for immunoglobulin domains in immune function.

Semin Immunol 2010 Feb 8;22(1):17-24. Epub 2009 Dec 8.

University of South Florida, Department of Pediatrics, USF/ACH Children's Research Institute, 140 Seventh Avenue South, St. Petersburg, FL 33701, USA.

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http://dx.doi.org/10.1016/j.smim.2009.11.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823954PMC
February 2010

A novel inhibitor of DNA polymerase beta enhances the ability of temozolomide to impair the growth of colon cancer cells.

Mol Cancer Res 2009 Dec 8;7(12):1973-83. Epub 2009 Dec 8.

Department of Anatomy and Cell Biology and University of Florida Shands Cancer Center, University of Florida, Gainesville, FL 32610, USA.

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http://dx.doi.org/10.1158/1541-7786.MCR-09-0309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2796282PMC
December 2009

Identification of tyrosine 972 as a novel site of Jak2 tyrosine kinase phosphorylation and its role in Jak2 activation.

Biochemistry 2008 Aug 18;47(32):8326-34. Epub 2008 Jul 18.

Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville, Florida 32610, USA.

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http://dx.doi.org/10.1021/bi800867dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636534PMC
August 2008

A bony fish immunological receptor of the NITR multigene family mediates allogeneic recognition.

Immunity 2008 Aug 31;29(2):228-37. Epub 2008 Jul 31.

Department of Pediatrics, University of South Florida College of Medicine, St. Petersburg, FL 33701, USA.

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http://dx.doi.org/10.1016/j.immuni.2008.05.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2603606PMC
August 2008

Z3, a novel Jak2 tyrosine kinase small-molecule inhibitor that suppresses Jak2-mediated pathologic cell growth.

Mol Cancer Ther 2008 Aug;7(8):2308-18

Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville, FL 32610, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-08-0279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2579271PMC
August 2008

A high-throughput screening method for small-molecule pharmacologic chaperones of misfolded rhodopsin.

Invest Ophthalmol Vis Sci 2008 Jul 31;49(7):3224-30. Epub 2008 Mar 31.

Department of Ophthalmology, the Charlie Mack Overstreet Laboratories for Retinal Diseases, University of Florida, Gainesville, Florida 32610, USA.

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http://dx.doi.org/10.1167/iovs.07-1539DOI Listing
July 2008

Molecular modeling optimization of anticoagulant pyridine derivatives.

J Mol Graph Model 2008 Jun 7;26(8):1365-9. Epub 2008 Feb 7.

University of Florida, Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, Gainesville, FL, USA.

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http://dx.doi.org/10.1016/j.jmgm.2008.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3752647PMC
June 2008

Crystallization of the focal adhesion kinase targeting (FAT) domain in a primitive orthorhombic space group.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2008 Jun 30;64(Pt 6):564-6. Epub 2008 May 30.

Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, 1600 SW Archer Road, Gainesville, FL 32610, USA.

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http://dx.doi.org/10.1107/S1744309108011421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2496861PMC
June 2008

Cardiovascular protection by angiotensin-converting enzyme 2: a new paradigm.

Future Cardiol 2008 Mar;4(2):175-82

University of Florida, Department of Physiology and Functional Genomics, College of Medicine, PO Box 100274, Gainesville, FL 32610, USA.

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http://dx.doi.org/10.2217/14796678.4.2.175DOI Listing
March 2008

Immunoglobulin variable regions in molecules exhibiting characteristics of innate and adaptive immune receptors.

Immunol Res 2007 ;38(1-3):294-304

Department of Pediatrics, University of South Florida College of Medicine, USF/ACH Children's Research Institute, 830 First Street South, St. Petersburg, FL 33701, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3690489PMC
January 2008

Crystallization and X-ray diffraction analysis of a novel immune-type receptor from Ictalurus punctatus and phasing by selenium anomalous dispersion methods.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2007 Dec 21;63(Pt 12):1035-7. Epub 2007 Nov 21.

Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, 1600 SW Archer Road, Gainesville, FL 32610, USA.

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http://dx.doi.org/10.1107/S1744309107054231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2344108PMC
December 2007

Discovery of novel DNA gyrase inhibitors by high-throughput virtual screening.

Antimicrob Agents Chemother 2007 Oct 6;51(10):3688-98. Epub 2007 Aug 6.

Department of Pathology, Immunology and Laboratory Medicine, University of Florida, College of Medicine, Gainesville, FL 32610, USA.

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http://dx.doi.org/10.1128/AAC.00392-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2043263PMC
October 2007

The N-terminal SH2 domain of the tyrosine phosphatase, SHP-2, is essential for Jak2-dependent signaling via the angiotensin II type AT1 receptor.

Cell Signal 2007 Mar 1;19(3):600-9. Epub 2006 Sep 1.

Department of Physiology and Functional Genomics, University of Florida College of Medicine Gainesville, FL 32610, United States.

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http://dx.doi.org/10.1016/j.cellsig.2006.08.010DOI Listing
March 2007

Ancient evolutionary origin of diversified variable regions demonstrated by crystal structures of an immune-type receptor in amphioxus.

Nat Immunol 2006 Aug 25;7(8):875-82. Epub 2006 Jun 25.

Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, Florida 32610, USA.

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http://dx.doi.org/10.1038/ni1359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3707131PMC
August 2006

Identification of 1,2,3,4,5,6-hexabromocyclohexane as a small molecule inhibitor of jak2 tyrosine kinase autophosphorylation [correction of autophophorylation].

J Med Chem 2005 Apr;48(7):2526-33

Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville, Florida 32610, USA.

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http://dx.doi.org/10.1021/jm049470kDOI Listing
April 2005

Structure-based discovery of a novel angiotensin-converting enzyme 2 inhibitor.

Hypertension 2004 Dec 18;44(6):903-6. Epub 2004 Oct 18.

Department of Physiology and Functional Genomics, College of Medicine, University of Florida, Gainesville, Fla 32610, USA.

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http://dx.doi.org/10.1161/01.HYP.0000146120.29648.36DOI Listing
December 2004

Resolution of the novel immune-type receptor gene cluster in zebrafish.

Proc Natl Acad Sci U S A 2004 Nov 20;101(44):15706-11. Epub 2004 Oct 20.

Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA.

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http://dx.doi.org/10.1073/pnas.0405242101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC524843PMC
November 2004

Crystallization and preliminary X-ray analysis of VCBP3 from Branchiostoma floridae.

Acta Crystallogr D Biol Crystallogr 2004 Nov 20;60(Pt 11):2022-4. Epub 2004 Oct 20.

Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, 1600 SW Archer Road, Gainesville, FL 32610, USA.

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http://dx.doi.org/10.1107/S0907444904020827DOI Listing
November 2004

Jak2 tyrosine kinase residues glutamic acid 1024 and arginine 1113 form a hydrogen bond interaction that is essential for Jak-STAT signal transduction.

Mol Cell Biochem 2004 Oct;265(1-2):161-9

Department of Physiology and Functional Genomics, University of Florida College of Medicine, PO Box 100274, Gainesville, FL 32610, USA.

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http://dx.doi.org/10.1023/b:mcbi.0000044393.67980.99DOI Listing
October 2004

Mechanisms of antigen receptor evolution.

Semin Immunol 2004 Aug;16(4):215-26

Department of Pediatrics, Children's Research Institute, University of South Florida College of Medicine, 830 First Street South, St. Petersburg, FL 33701, USA.

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http://dx.doi.org/10.1016/j.smim.2004.08.001DOI Listing
August 2004