Daniel Spinks

Daniel Spinks

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Daniel Spinks

Daniel Spinks

Publications by authors named "Daniel Spinks"

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2,4-Diamino-6-methylpyrimidines for the potential treatment of Chagas' disease.

Bioorg Med Chem Lett 2018 10 3;28(18):3025-3030. Epub 2018 Aug 3.

Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2018.08.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6970618PMC
October 2018

Screening a protein kinase inhibitor library against Plasmodium falciparum.

Malar J 2017 11 7;16(1):446. Epub 2017 Nov 7.

Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK.

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http://dx.doi.org/10.1186/s12936-017-2085-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678585PMC
November 2017

Design, synthesis and biological evaluation of Trypanosoma brucei trypanothione synthetase inhibitors.

ChemMedChem 2012 Jan 8;7(1):95-106. Epub 2011 Dec 8.

Drug Discovery Unit, Division of Biological Chemistry & Drug Discovery, College of Life Sciences, University of Dundee, Dundee, UK.

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http://dx.doi.org/10.1002/cmdc.201100420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320663PMC
January 2012

Optimisation of the anti-Trypanosoma brucei activity of the opioid agonist U50488.

ChemMedChem 2011 Oct 10;6(10):1832-40. Epub 2011 Aug 10.

Drug Discovery Unit, College of Life Sciences, James Black Centre, University of Dundee, Dundee, DD1 5EH, Scotland, UK.

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http://dx.doi.org/10.1002/cmdc.201100278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229842PMC
October 2011

Design, synthesis and biological evaluation of novel inhibitors of Trypanosoma brucei pteridine reductase 1.

ChemMedChem 2011 Feb 29;6(2):302-8. Epub 2010 Dec 29.

Drug Discovery Unit, Division of Biological Chemistry & Drug Discovery, College of Life Sciences, University of Dundee, Sir James Black Centre, Dundee, Scotland, DD1 5EH, UK.

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http://dx.doi.org/10.1002/cmdc.201000450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3047710PMC
February 2011

Chemical validation of trypanothione synthetase: a potential drug target for human trypanosomiasis.

J Biol Chem 2009 Dec 14;284(52):36137-45. Epub 2009 Oct 14.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M109.045336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2794729PMC
December 2009

Investigation of trypanothione reductase as a drug target in Trypanosoma brucei.

ChemMedChem 2009 Dec;4(12):2060-9

Drug Discovery Unit, College of Life Sciences, University of Dundee, Sir James Black Centre, Dundee, DD1 5EH, UK.

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http://dx.doi.org/10.1002/cmdc.200900262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855869PMC
December 2009

Dissecting the essentiality of the bifunctional trypanothione synthetase-amidase in Trypanosoma brucei using chemical and genetic methods.

Mol Microbiol 2009 Nov 24;74(3):529-40. Epub 2009 Jun 24.

Division of Biological Chemistry and Drug Discovery, Wellcome Trust Biocentre, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, Scotland, UK.

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http://doi.wiley.com/10.1111/j.1365-2958.2009.06761.x
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http://dx.doi.org/10.1111/j.1365-2958.2009.06761.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2784880PMC
November 2009

2-Aryl-3,3,3-trifluoro-2-hydroxypropionic acids: a new class of protein tyrosine phosphatase 1B inhibitors.

Bioorg Med Chem Lett 2007 Dec 25;17(23):6579-83. Epub 2007 Sep 25.

Department of Chemistry, School of Engineering & Physical Sciences, Heriot-Watt University, Edinburgh EH14 4AS, UK.

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http://dx.doi.org/10.1016/j.bmcl.2007.09.069DOI Listing
December 2007