Publications by authors named "Daniel K Afosah"

11Publications

Studies on fragment-based design of allosteric inhibitors of human factor XIa.

Bioorg Med Chem 2020 Sep 13;28(23):115762. Epub 2020 Sep 13.

Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298, United States; Institute for Structural Biology, Drug Discovery and Development, Virginia Commonwealth University, Richmond, VA 23219, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2020.115762DOI Listing
September 2020

On the Process of Discovering Leads That Target the Heparin-Binding Site of Neutrophil Elastase in the Sputum of Cystic Fibrosis Patients.

J Med Chem 2019 06 28;62(11):5501-5511. Epub 2019 May 28.

Department of Medicinal Chemistry , Virginia Commonwealth University , Richmond , Virginia 23298 , United States.

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http://dx.doi.org/10.1021/acs.jmedchem.9b00379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6818412PMC
June 2019

Sulfated Non-Saccharide Glycosaminoglycan Mimetics as Novel Drug Discovery Platform for Various Pathologies.

Curr Med Chem 2020 ;27(21):3412-3447

Division of Basic Pharmaceutical Sciences, College of Pharmacy, Xavier University of Louisiana, New Orleans, Louisiana 70125, United States.

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http://dx.doi.org/10.2174/0929867325666181120101147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6551317PMC
August 2020

Inhibition of Herpes Simplex Virus-1 Entry into Human Cells by Nonsaccharide Glycosaminoglycan Mimetics.

ACS Med Chem Lett 2018 Aug 16;9(8):797-802. Epub 2018 Jul 16.

Institute for Structural Biology, Drug Discovery and Development, Virginia Commonwealth University, Richmond, Virginia 23219, United States.

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http://dx.doi.org/10.1021/acsmedchemlett.7b00364DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6088358PMC
August 2018

Recent advances in the discovery and development of factor XI/XIa inhibitors.

Med Res Rev 2018 09 4;38(6):1974-2023. Epub 2018 May 4.

Department of Medicinal Chemistry, and Institute for Structural Biology, Drug Discovery and Development, Virginia Commonwealth University, Richmond, VA, USA.

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http://dx.doi.org/10.1002/med.21503DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173998PMC
September 2018

A small group of sulfated benzofurans induces steady-state submaximal inhibition of thrombin.

Bioorg Med Chem Lett 2018 04 3;28(6):1101-1105. Epub 2018 Feb 3.

Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, VA, USA; Institute for Structural Biology, Drug Discovery and Development, Virginia Commonwealth University, Richmond, VA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2018.01.069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5851871PMC
April 2018

Potent, Selective, Allosteric Inhibition of Human Plasmin by Sulfated Non-Saccharide Glycosaminoglycan Mimetics.

J Med Chem 2017 01 5;60(2):641-657. Epub 2017 Jan 5.

Department of Medicinal Chemistry, and Institute for Structural Biology, Drug Discovery and Development, Virginia Commonwealth University , Richmond, Virginia 23219, United States.

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http://dx.doi.org/10.1021/acs.jmedchem.6b01474DOI Listing
January 2017

Allosteric Inhibition of Factor XIIIa. Non-Saccharide Glycosaminoglycan Mimetics, but Not Glycosaminoglycans, Exhibit Promising Inhibition Profile.

PLoS One 2016 28;11(7):e0160189. Epub 2016 Jul 28.

Department of Medicinal Chemistry & Institute for Structural Biology, Drug Discovery and Development, Virginia Commonwealth University, Richmond, Virginia, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0160189PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965010PMC
August 2017