Daniel J Tschumperlin

Daniel J Tschumperlin

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Daniel J Tschumperlin

Daniel J Tschumperlin

Publications by authors named "Daniel J Tschumperlin"

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Spinal cord injury results in chronic mechanical stiffening.

J Neurotrauma 2019 Sep 13. Epub 2019 Sep 13.

Northwestern University Feinberg School of Medicine, 12244, Department of Neurology, Chicago, Illinois, United States;

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http://dx.doi.org/10.1089/neu.2019.6540DOI Listing
September 2019

TGFβ-induced fibroblast activation requires persistent and targeted HDAC-mediated gene repression.

J Cell Sci 2019 Sep 16. Epub 2019 Sep 16.

Department of Physiology & Biomedical Engineering, Mayo Clinic, Rochester, MN, USA

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http://dx.doi.org/10.1242/jcs.233486DOI Listing
September 2019

Nascent Lung Organoids Reveal Epithelium- and BMP-Mediated Suppression of Fibroblast Activation.

Am J Respir Cell Mol Biol 2019 May 3. Epub 2019 May 3.

Mayo Clinic, Physiology & Biomedical Engineering, Rochester, Minnesota, United States ;

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http://dx.doi.org/10.1165/rcmb.2018-0390OCDOI Listing
May 2019

Profibrotic effect of IL-17A and elevated IL-17RA in idiopathic pulmonary fibrosis and rheumatoid arthritis-associated lung disease support a direct role for IL-17A/IL-17RA in human fibrotic interstitial lung disease.

Am J Physiol Lung Cell Mol Physiol 2019 Mar 3;316(3):L487-L497. Epub 2019 Jan 3.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic College of Medicine and Science , Rochester, Minnesota.

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http://dx.doi.org/10.1152/ajplung.00301.2018DOI Listing
March 2019

Matrix biomechanics and dynamics in pulmonary fibrosis.

Matrix Biol 2018 11 21;73:64-76. Epub 2017 Dec 21.

Department of Physiology and Biomedical Engineering, Mayo Clinic, 200 First St SW, Rochester, MN 55905, United States. Electronic address:

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http://dx.doi.org/10.1016/j.matbio.2017.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013326PMC
November 2018

Epigenome Editing Enters the Arena. A New Tool to Reveal (and Reverse?) Pathologic Gene Regulation.

Am J Respir Crit Care Med 2018 09;198(5):549-551

1 Department of Physiology & Biomedical Engineering Mayo Clinic College of Medicine and Science Rochester Minnesota.

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http://dx.doi.org/10.1164/rccm.201807-1239EDDOI Listing
September 2018

Mechanobiological Feedback in Pulmonary Vascular Disease.

Front Physiol 2018 25;9:951. Epub 2018 Jul 25.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, United States.

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http://dx.doi.org/10.3389/fphys.2018.00951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068271PMC
July 2018

Aging and anatomical variations in lung tissue stiffness.

Am J Physiol Lung Cell Mol Physiol 2018 06 22;314(6):L946-L955. Epub 2018 Feb 22.

Department of Physiology and Biomedical Engineering, College of Medicine and Science, Mayo Clinic , Rochester, Minnesota.

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http://dx.doi.org/10.1152/ajplung.00415.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032071PMC
June 2018

Regulation of fibroblast Fas expression by soluble and mechanical pro-fibrotic stimuli.

Respir Res 2018 05 10;19(1):91. Epub 2018 May 10.

Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School, 6303 MSRB 3, 1150 W. Medical Center Drive, Ann Arbor, MI, 48109-5642, USA.

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http://dx.doi.org/10.1186/s12931-018-0801-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946418PMC
May 2018

Mechanosensing and fibrosis.

J Clin Invest 2018 01 2;128(1):74-84. Epub 2018 Jan 2.

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.

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http://dx.doi.org/10.1172/JCI93561DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749510PMC
January 2018

Targeting Senescent Cells in Fibrosis: Pathology, Paradox, and Practical Considerations.

Curr Rheumatol Rep 2018 01 26;20(1). Epub 2018 Jan 26.

Robert and Arlene Kogod Center on Aging, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN, 55905, USA.

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http://link.springer.com/10.1007/s11926-018-0712-x
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http://dx.doi.org/10.1007/s11926-018-0712-xDOI Listing
January 2018

Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis.

Sci Transl Med 2017 Dec;9(420)

Fibrosis Research Center and Center for Immunology and Inflammatory Diseases, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1126/scitranslmed.aal3765DOI Listing
December 2017

Lysyl oxidases regulate fibrillar collagen remodelling in idiopathic pulmonary fibrosis.

Dis Model Mech 2017 11;10(11):1301-1312

Respiratory Cellular and Molecular Biology Group, Woolcock Institute of Medical Research, Glebe, New South Wales 2037, Australia

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http://dx.doi.org/10.1242/dmm.030114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719253PMC
November 2017

Measured pulmonary arterial tissue stiffness is highly sensitive to AFM indenter dimensions.

J Mech Behav Biomed Mater 2017 10 31;74:118-127. Epub 2017 May 31.

Department of Physiology & Biomedical Engineering, College of Medicine, Mayo Clinic, 200 1st St SW, Rochester, MN 55906, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jmbbm.2017.05.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5582007PMC
October 2017

Phenylpyrrolidine structural mimics of pirfenidone lacking antifibrotic activity: A new tool for mechanism of action studies.

Eur J Pharmacol 2017 Sep 30;811:87-92. Epub 2017 May 30.

Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ejphar.2017.05.050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5581985PMC
September 2017

Arterial stiffness induces remodeling phenotypes in pulmonary artery smooth muscle cells via YAP/TAZ-mediated repression of cyclooxygenase-2.

Am J Physiol Lung Cell Mol Physiol 2017 Sep 22;313(3):L628-L647. Epub 2017 Jun 22.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts;

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http://dx.doi.org/10.1152/ajplung.00173.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5625262PMC
September 2017

TAZ activation drives fibroblast spheroid growth, expression of profibrotic paracrine signals, and context-dependent ECM gene expression.

Am J Physiol Cell Physiol 2017 Mar 23;312(3):C277-C285. Epub 2016 Nov 23.

Department of Physiology and Biomedical Engineering, College of Medicine, Mayo Clinic, Rochester, Minnesota; and

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http://dx.doi.org/10.1152/ajpcell.00205.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5401948PMC
March 2017

Human airway organoid engineering as a step toward lung regeneration and disease modeling.

Biomaterials 2017 01 28;113:118-132. Epub 2016 Oct 28.

Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2016.10.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121055PMC
January 2017

Use of Shear Wave Ultrasound Vibrometry for Detection of Simulated Esophageal Malignancy in Porcine Esophagi.

Biomed Phys Eng Express 2016 23;2(6). Epub 2016 Nov 23.

Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN 55905.

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http://dx.doi.org/10.1088/2057-1976/2/6/065002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609727PMC
November 2016

Nondestructive measurement of esophageal biaxial mechanical properties utilizing sonometry.

Phys Med Biol 2016 07 8;61(13):4781-95. Epub 2016 Jun 8.

Division of General Thoracic Surgery, Department of Surgery, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA. Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1088/0031-9155/61/13/4781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972185PMC
July 2016

Coming to terms with tissue engineering and regenerative medicine in the lung.

Am J Physiol Lung Cell Mol Physiol 2015 Oct 7;309(7):L625-38. Epub 2015 Aug 7.

Department of Pediatrics, University of Colorado, Aurora, Colorado.

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http://dx.doi.org/10.1152/ajplung.00204.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593835PMC
October 2015

Matrix stiffness-modulated proliferation and secretory function of the airway smooth muscle cells.

Am J Physiol Lung Cell Mol Physiol 2015 Jun 27;308(11):L1125-35. Epub 2015 Feb 27.

Departments of Chemical and Biomolecular Engineering, Pathobiology, and Bioengineering, Institute of Genomic Biology, Univeristy of Illinois at Urbana-Champaign, Urbana, Illinois; and Deptartment of Chemical Engineering, Soongshil University, Seoul, Korea

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http://dx.doi.org/10.1152/ajplung.00154.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451397PMC
June 2015

Matrix, mesenchyme, and mechanotransduction.

Ann Am Thorac Soc 2015 Mar;12 Suppl 1:S24-9

Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota.

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http://dx.doi.org/10.1513/AnnalsATS.201407-320MGDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4430972PMC
March 2015

Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis.

Am J Physiol Lung Cell Mol Physiol 2015 Feb 12;308(4):L344-57. Epub 2014 Dec 12.

Molecular and Integrative Physiological Sciences, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota;

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http://dx.doi.org/10.1152/ajplung.00300.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4329470PMC
February 2015

Soft matrix is a natural stimulator for cellular invasiveness.

Mol Biol Cell 2014 Feb 11;25(4):457-69. Epub 2013 Dec 11.

Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115 Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, TX 77054 Molecular and Integrative Physiological Sciences, Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115 Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905.

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http://dx.doi.org/10.1091/mbc.E13-05-0260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923638PMC
February 2014

Fibroblasts and the ground they walk on.

Physiology (Bethesda) 2013 Nov;28(6):380-90

Department of Environmental Health, Molecular and Integrative Physiological Sciences, Harvard School of Public Health, Boston, Massachusetts.

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http://dx.doi.org/10.1152/physiol.00024.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858213PMC
November 2013

Human neutrophil elastase-mediated goblet cell metaplasia is attenuated in TACE-deficient mice.

Am J Physiol Lung Cell Mol Physiol 2013 May 5;304(10):L701-7. Epub 2013 Apr 5.

Molecular and Integrative Physiological Sciences Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA.

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http://ajplung.physiology.org/content/ajplung/304/10/L701.fu
Web Search
http://ajplung.physiology.org/cgi/doi/10.1152/ajplung.00259.
Publisher Site
http://dx.doi.org/10.1152/ajplung.00259.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652059PMC
May 2013

Matrices of physiologic stiffness potently inactivate idiopathic pulmonary fibrosis fibroblasts.

Am J Respir Cell Mol Biol 2013 Apr;48(4):422-30

Division of Molecular and Integrative Physiological Sciences, Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA.

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http://dx.doi.org/10.1165/rcmb.2012-0335OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3653602PMC
April 2013

Matrix stiffness corresponding to strictured bowel induces a fibrogenic response in human colonic fibroblasts.

Inflamm Bowel Dis 2013 Apr;19(5):891-903

Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109-5682, USA.

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http://dx.doi.org/10.1097/MIB.0b013e3182813297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766259PMC
April 2013

Biomechanical regulation of mesenchymal cell function.

Curr Opin Rheumatol 2013 Jan;25(1):92-100

Molecular and Integrative Physiological Sciences, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115-6021, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056746PMC
http://dx.doi.org/10.1097/BOR.0b013e32835b13cdDOI Listing
January 2013

Tissue factor-bearing exosome secretion from human mechanically stimulated bronchial epithelial cells in vitro and in vivo.

J Allergy Clin Immunol 2012 Dec 22;130(6):1375-83. Epub 2012 Jul 22.

Molecular and Integrative Physiological Sciences Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.jaci.2012.05.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511625PMC
December 2012

Matrix stiffness reverses the effect of actomyosin tension on cell proliferation.

J Cell Sci 2012 Dec 24;125(Pt 24):5974-83. Epub 2012 Oct 24.

Molecular and Integrative Physiological Sciences, Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA.

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http://dx.doi.org/10.1242/jcs.108886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585515PMC
December 2012

Improved throughput traction microscopy reveals pivotal role for matrix stiffness in fibroblast contractility and TGF-β responsiveness.

Am J Physiol Lung Cell Mol Physiol 2012 Aug 1;303(3):L169-80. Epub 2012 Jun 1.

Molecular and Integrative Physiological Sciences, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1152/ajplung.00108.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423859PMC
August 2012

A multiwell platform for studying stiffness-dependent cell biology.

PLoS One 2011 27;6(5):e19929. Epub 2011 May 27.

Molecular and Integrative Physiological Sciences, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0019929PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3103526PMC
September 2011

TNF-α-converting enzyme/a disintegrin and metalloprotease-17 mediates mechanotransduction in murine tracheal epithelial cells.

Am J Respir Cell Mol Biol 2011 Aug 19;45(2):376-85. Epub 2010 Nov 19.

Molecular and Integrative Physiological Sciences Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA.

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http://dx.doi.org/10.1165/rcmb.2010-0234OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3175563PMC
August 2011

Micro-mechanical characterization of lung tissue using atomic force microscopy.

J Vis Exp 2011 Aug 28(54). Epub 2011 Aug 28.

Molecular and Integrative Physiological Sciences, Department of Environmental Health, Harvard School of Public Health, USA.

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http://dx.doi.org/10.3791/2911DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3217627PMC
August 2011

Lysophosphatidic acid stimulates epidermal growth factor-family ectodomain shedding and paracrine signaling from human lung fibroblasts.

Wound Repair Regen 2011 Mar-Apr;19(2):229-40

Molecular and Integrative Physiological Sciences Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1111/j.1524-475X.2010.00655.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3076689PMC
June 2011

Physical forces and airway remodeling in asthma.

N Engl J Med 2011 May;364(21):2058-9

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http://dx.doi.org/10.1056/NEJMe1103121DOI Listing
May 2011

Mechanotransduction.

Compr Physiol 2011 Apr;1(2):1057-73

Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA.

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http://dx.doi.org/10.1002/cphy.c100016DOI Listing
April 2011

A 3-D model of ligand transport in a deforming extracellular space.

Biophys J 2010 Dec;99(11):3517-25

Harvard-MIT Division of Health Sciences and Technology, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1016/j.bpj.2010.09.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2998622PMC
December 2010

The chitinase-like protein YKL-40 is secreted by airway epithelial cells at base line and in response to compressive mechanical stress.

J Biol Chem 2010 Sep 22;285(39):29817-25. Epub 2010 Jul 22.

Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1074/jbc.M110.103416DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943267PMC
September 2010

Matrix rigidity regulates cancer cell growth and cellular phenotype.

PLoS One 2010 Sep 23;5(9):e12905. Epub 2010 Sep 23.

Department of Microbiology and Cancer Center, School of Medicine, University of Virginia, Charlottesville, Virginia, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0012905PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2944843PMC
September 2010

Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression.

J Cell Biol 2010 Aug;190(4):693-706

Molecular and Integrative Physiological Sciences, Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115.

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http://dx.doi.org/10.1083/jcb.201004082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928007PMC
August 2010

Stretch-induced mitogen-activated protein kinase activation in lung fibroblasts is independent of receptor tyrosine kinases.

Am J Respir Cell Mol Biol 2010 Jul 14;43(1):64-73. Epub 2009 Aug 14.

Department of Environmental Health, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA.

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http://dx.doi.org/10.1165/rcmb.2009-0092OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911572PMC
July 2010

An EGFR autocrine loop encodes a slow-reacting but dominant mode of mechanotransduction in a polarized epithelium.

FASEB J 2010 May 7;24(5):1604-15. Epub 2010 Jan 7.

Division of Health Sciences and Technology, Harvard-Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1096/fj.09-145367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2879944PMC
May 2010

Recent advances and new opportunities in lung mechanobiology.

J Biomech 2010 Jan 4;43(1):99-107. Epub 2009 Oct 4.

Molecular and Integrative Physiological Sciences, Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.jbiomech.2009.09.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2813412PMC
January 2010

Chronic intermittent mechanical stress increases MUC5AC protein expression.

Am J Respir Cell Mol Biol 2009 Oct 23;41(4):459-66. Epub 2009 Jan 23.

Molecular and Integrative Physiological Sciences Program, Harvard School of Public Health, 665 Huntington Ave., SPH1-309, Boston, MA 02115, USA.

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http://dx.doi.org/10.1165/rcmb.2008-0195OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2746990PMC
October 2009

Induction of the plasminogen activator system by mechanical stimulation of human bronchial epithelial cells.

Am J Respir Cell Mol Biol 2006 Dec 22;35(6):628-38. Epub 2006 Jun 22.

Brigham and Women's Hospital, Department of Pulmonary and Critical Care Medicine, Harvard School of Public Health, Physiology Program and Children's Hospital Informatics Program, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1165/rcmb.2006-0040OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2643292PMC
December 2006

Chronic effects of mechanical force on airways.

Annu Rev Physiol 2006 ;68:563-83

Physiology Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1146/annurev.physiol.68.072304.113102DOI Listing
June 2006

Computational modeling of extracellular mechanotransduction.

Biophys J 2006 Jun 13;90(11):4261-70. Epub 2006 Mar 13.

Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA, USA.

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http://dx.doi.org/10.1529/biophysj.105.078345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1459528PMC
June 2006

Bronchial epithelial compression regulates epidermal growth factor receptor family ligand expression in an autocrine manner.

Am J Respir Cell Mol Biol 2005 May 10;32(5):373-80. Epub 2005 Feb 10.

Department of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA.

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http://dx.doi.org/10.1165/rcmb.2004-0266OCDOI Listing
May 2005

EGFR autocrine signaling in a compliant interstitial space: mechanotransduction from the outside in.

Cell Cycle 2004 Aug 25;3(8):996-7. Epub 2004 Aug 25.

Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA.

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http://dx.doi.org/10.4161/cc.3.8.1062DOI Listing
August 2004

Differentiation-dependent responsiveness of bronchial epithelial cells to IL-4/13 stimulation.

Am J Physiol Lung Cell Mol Physiol 2004 Jul 12;287(1):L119-26. Epub 2004 Mar 12.

Pulmonary and Critical Care Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1152/ajplung.00365.2003DOI Listing
July 2004

Mechanotransduction through growth-factor shedding into the extracellular space.

Nature 2004 May 21;429(6987):83-6. Epub 2004 Apr 21.

Physiology Program, Department of Environmental Health, Harvard School of Public Health, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nature02543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5539413PMC
May 2004

Mechanical stress triggers selective release of fibrotic mediators from bronchial epithelium.

Am J Respir Cell Mol Biol 2003 Feb;28(2):142-9

Pulmonary and Critical Care Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1165/rcmb.2002-0121OCDOI Listing
February 2003

Bronchial epithelial compression regulates MAP kinase signaling and HB-EGF-like growth factor expression.

Am J Physiol Lung Cell Mol Physiol 2002 May;282(5):L904-11

Physiology Program, Department of Environmental Health, Harvard School of Public Health, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1152/ajplung.00270.2001DOI Listing
May 2002