Daniel A Haber

Daniel A Haber

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Daniel A Haber

Daniel A Haber

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Microfluidic concentration and separation of circulating tumor cell clusters from large blood volumes.

Authors:
Jon F Edd Avanish Mishra Taronish D Dubash Stefan Herrera Ridhwan Mohammad E Kendall Williams Xin Hong Baris R Mutlu John R Walsh Fernanda Machado de Carvalho Berent Aldikacti Linda T Nieman Shannon L Stott Ravi Kapur Shyamala Maheswaran Daniel A Haber Mehmet Toner

Lab Chip 2020 Jan 14. Epub 2020 Jan 14.

BioMEMS Resource Center, Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA. and Shriners Hospitals for Children, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1039/c9lc01122fDOI Listing
January 2020

Epithelial to mesenchymal plasticity and differential response to therapies in pancreatic ductal adenocarcinoma.

Authors:
Rebecca L Porter Neelima K C Magnus Vishal Thapar Robert Morris Annamaria Szabolcs Azfar Neyaz Anupriya S Kulkarni Eric Tai Abhijit Chougule Alissandra Hillis Gabriel Golczer Hongshan Guo Teppei Yamada Tomohiro Kurokawa Chittampalli Yashaswini Matteo Ligorio Kevin D Vo Linda Nieman Andrew S Liss Vikram Deshpande Michael S Lawrence Shyamala Maheswaran Carlos Fernandez-Del Castillo Theodore S Hong David P Ryan Peter J O'Dwyer Jeffrey A Drebin Cristina R Ferrone Daniel A Haber David T Ting

Proc Natl Acad Sci U S A 2019 12 16. Epub 2019 Dec 16.

Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02114;

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http://dx.doi.org/10.1073/pnas.1914915116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936349PMC
December 2019

Modeling gamma radiation exposure rates using geologic and remote sensing data to locate radiogenic anomalies.

Authors:
Christopher T Adcock Daniel A Haber Pamela C Burnley Russell L Malchow Elisabeth M Hausrath

J Environ Radioact 2019 Nov 6;208-209:106038. Epub 2019 Sep 6.

University of Nevada Las Vegas, Geoscience Department, 4505 S Maryland Parkway, Las Vegas, NV, 89154, United States.

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http://dx.doi.org/10.1016/j.jenvrad.2019.106038DOI Listing
November 2019

Combination Olaparib and Temozolomide in Relapsed Small-Cell Lung Cancer.

Authors:
Anna F Farago Beow Y Yeap Marcello Stanzione Yin P Hung Rebecca S Heist J Paul Marcoux Jun Zhong Deepa Rangachari David A Barbie Sarah Phat David T Myers Robert Morris Marina Kem Taronish D Dubash Elizabeth A Kennedy Subba R Digumarthy Lecia V Sequist Aaron N Hata Shyamala Maheswaran Daniel A Haber Michael S Lawrence Alice T Shaw Mari Mino-Kenudson Nicholas J Dyson Benjamin J Drapkin

Cancer Discov 2019 Oct 15;9(10):1372-1387. Epub 2019 Aug 15.

Massachusetts General Hospital Cancer Center, Boston, Massachusetts.

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http://dx.doi.org/10.1158/2159-8290.CD-19-0582DOI Listing
October 2019

Quantitative Analysis of Circulating Tumor Cells Using RNA-Based Digital Scoring.

Authors:
Mark Kalinich Tanya T Kwan Mehmet Toner Daniel A Haber Shyamala Maheswaran

Recent Results Cancer Res 2020 ;215:77-88

Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, MA, 02129, USA.

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http://dx.doi.org/10.1007/978-3-030-26439-0_4DOI Listing
October 2019

Blood-based monitoring identifies acquired and targetable driver mutations in endocrine-resistant metastatic breast cancer.

Authors:
Arielle J Medford Taronish D Dubash Dejan Juric Laura Spring Andrzej Niemierko Neelima Vidula Jeffrey Peppercorn Steven Isakoff Brittany A Reeves Joseph A LiCausi Benjamin Wesley Giuliana Malvarosa Megan Yuen Ben S Wittner Michael S Lawrence A John Iafrate Leif Ellisen Beverly Moy Mehmet Toner Shyamala Maheswaran Daniel A Haber Aditya Bardia

NPJ Precis Oncol 2019 16;3:18. Epub 2019 Jul 16.

1Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129 USA.

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http://dx.doi.org/10.1038/s41698-019-0090-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6635494PMC
July 2019

Visualizing Engrafted Human Cancer and Therapy Responses in Immunodeficient Zebrafish.

Authors:
Chuan Yan Dalton C Brunson Qin Tang Daniel Do Nicolae A Iftimia John C Moore Madeline N Hayes Alessandra M Welker Elaine G Garcia Taronish D Dubash Xin Hong Benjamin J Drapkin David T Myers Sarah Phat Angela Volorio Dieuwke L Marvin Matteo Ligorio Lyle Dershowitz Karin M McCarthy Murat N Karabacak Jonathan A Fletcher Dennis C Sgroi John A Iafrate Shyamala Maheswaran Nick J Dyson Daniel A Haber John F Rawls David M Langenau

Cell 2019 Jun 25;177(7):1903-1914.e14. Epub 2019 Apr 25.

Molecular Pathology Unit, Massachusetts General Hospital Research Institute, Charlestown, MA 02129, USA; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Stem Cell Institute, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6570580PMC
June 2019

Stromal Microenvironment Shapes the Intratumoral Architecture of Pancreatic Cancer.

Authors:
Matteo Ligorio Srinjoy Sil Jose Malagon-Lopez Linda T Nieman Sandra Misale Mauro Di Pilato Richard Y Ebright Murat N Karabacak Anupriya S Kulkarni Ann Liu Nicole Vincent Jordan Joseph W Franses Julia Philipp Johannes Kreuzer Niyati Desai Kshitij S Arora Mihir Rajurkar Elad Horwitz Azfar Neyaz Eric Tai Neelima K C Magnus Kevin D Vo Chittampalli N Yashaswini Francesco Marangoni Myriam Boukhali Jackson P Fatherree Leah J Damon Kristina Xega Rushil Desai Melissa Choz Francesca Bersani Adam Langenbucher Vishal Thapar Robert Morris Ulrich F Wellner Oliver Schilling Michael S Lawrence Andrew S Liss Miguel N Rivera Vikram Deshpande Cyril H Benes Shyamala Maheswaran Daniel A Haber Carlos Fernandez-Del-Castillo Cristina R Ferrone Wilhelm Haas Martin J Aryee David T Ting

Cell 2019 Jun 30;178(1):160-175.e27. Epub 2019 May 30.

Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.05.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6697165PMC
June 2019

SETD1A protects from senescence through regulation of the mitotic gene expression program.

Authors:
Ken Tajima Satoru Matsuda Toshifumi Yae Benjamin J Drapkin Robert Morris Myriam Boukhali Kira Niederhoffer Valentine Comaills Taronish Dubash Linda Nieman Hongshan Guo Neelima K C Magnus Nick Dyson Toshihiro Shioda Wilhelm Haas Daniel A Haber Shyamala Maheswaran

Nat Commun 2019 06 28;10(1):2854. Epub 2019 Jun 28.

Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA, 02129, USA.

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http://www.nature.com/articles/s41467-019-10786-w
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http://dx.doi.org/10.1038/s41467-019-10786-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599037PMC
June 2019

Highly Multiplexed Fluorescence in Situ Hybridization for in Situ Genomics.

Authors:
Maristela L Onozato Clarence Yapp Douglas Richardson Tilak Sundaresan Varun Chahal Jesse Lee James P Sullivan Marisa W Madden Hyo S Shim Matthew Liebers Quan Ho Shyamala Maheswaran Daniel A Haber Zongli Zheng Brian Clancy Hunter L Elliott Jochen K Lennerz A John Iafrate

J Mol Diagn 2019 May 9;21(3):390-407. Epub 2019 Mar 9.

Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts; Cancer Center, Massachusetts General Hospital, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.jmoldx.2019.01.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504678PMC
May 2019

COX-2 mediates tumor-stromal prolactin signaling to initiate tumorigenesis.

Authors:
Yu Zheng Valentine Comaills Risa Burr Gaylor Boulay David T Miyamoto Ben S Wittner Erin Emmons Srinjoy Sil Michael W Koulopoulos Katherine T Broderick Eric Tai Shruthi Rengarajan Anupriya S Kulkarni Toshi Shioda Chin-Lee Wu Sridhar Ramaswamy David T Ting Mehmet Toner Miguel N Rivera Shyamala Maheswaran Daniel A Haber

Proc Natl Acad Sci U S A 2019 03 28;116(12):5223-5232. Epub 2019 Feb 28.

Massachusetts General Hospital Cancer Center,Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129;

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http://dx.doi.org/10.1073/pnas.1819303116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431196PMC
March 2019

Detection and Analysis of Circulating Epithelial Cells in Liquid Biopsies From Patients With Liver Disease.

Authors:
Irun Bhan Kelly Mosesso Lipika Goyal Julia Philipp Mark Kalinich Joseph W Franses Melissa Choz Rahmi Oklu Mehmet Toner Shyamala Maheswaran Daniel A Haber Andrew X Zhu Raymond T Chung Martin Aryee David T Ting

Gastroenterology 2018 12 13;155(6):2016-2018.e11. Epub 2018 Sep 13.

Cancer Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2018.09.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347478PMC
December 2018

A Digital RNA Signature of Circulating Tumor Cells Predicting Early Therapeutic Response in Localized and Metastatic Breast Cancer.

Authors:
Tanya T Kwan Aditya Bardia Laura M Spring Anita Giobbie-Hurder Mark Kalinich Taronish Dubash Tilak Sundaresan Xin Hong Joseph A LiCausi Uyen Ho Erin J Silva Ben S Wittner Lecia V Sequist Ravi Kapur David T Miyamoto Mehmet Toner Daniel A Haber Shyamala Maheswaran

Cancer Discov 2018 10 13;8(10):1286-1299. Epub 2018 Aug 13.

Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts.

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http://dx.doi.org/10.1158/2159-8290.CD-18-0432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170694PMC
October 2018

Improved Detection of Circulating Epithelial Cells in Patients with Intraductal Papillary Mucinous Neoplasms.

Authors:
Joseph W Franses Omer Basar Abdurrahman Kadayifci Osman Yuksel Melissa Choz Anupriya S Kulkarni Eric Tai Kevin D Vo Kshitu S Arora Niyati Desai Joseph A Licausi Mehmet Toner Shyamala Maheswaran Daniel A Haber David P Ryan William R Brugge David T Ting

Oncologist 2018 Oct;23(10):1260

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http://dx.doi.org/10.1634/theoncologist.2017-0234erratumDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263117PMC
October 2018

Genomic and Functional Fidelity of Small Cell Lung Cancer Patient-Derived Xenografts.

Authors:
Benjamin J Drapkin Julie George Camilla L Christensen Mari Mino-Kenudson Ruben Dries Tilak Sundaresan Sarah Phat David T Myers Jun Zhong Peter Igo Mehlika H Hazar-Rethinam Joseph A Licausi Maria Gomez-Caraballo Marina Kem Kandarp N Jani Roxana Azimi Nima Abedpour Roopika Menon Sotirios Lakis Rebecca S Heist Reinhard Büttner Stefan Haas Lecia V Sequist Alice T Shaw Kwok-Kin Wong Aaron N Hata Mehmet Toner Shyamala Maheswaran Daniel A Haber Martin Peifer Nicholas Dyson Roman K Thomas Anna F Farago

Cancer Discov 2018 05 26;8(5):600-615. Epub 2018 Feb 26.

Massachusetts General Hospital Cancer Center, Boston, Massachusetts.

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http://cancerdiscovery.aacrjournals.org/lookup/doi/10.1158/2
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http://dx.doi.org/10.1158/2159-8290.CD-17-0935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369413PMC
May 2018

AR Expression in Breast Cancer CTCs Associates with Bone Metastases.

Authors:
Nicola Aceto Aditya Bardia Ben S Wittner Maria C Donaldson Ryan O'Keefe Amanda Engstrom Francesca Bersani Yu Zheng Valentine Comaills Kira Niederhoffer Huili Zhu Olivia Mackenzie Toshi Shioda Dennis Sgroi Ravi Kapur David T Ting Beverly Moy Sridhar Ramaswamy Mehmet Toner Daniel A Haber Shyamala Maheswaran

Mol Cancer Res 2018 04 16;16(4):720-727. Epub 2018 Feb 16.

Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1541-7786.MCR-17-0480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882540PMC
April 2018

Ultra-fast vitrification of patient-derived circulating tumor cell lines.

Authors:
Rebecca D Sandlin Keith H K Wong Shannon N Tessier Anisa Swei Lauren D Bookstaver Bennett E Ahearn Shyamala Maheswaran Daniel A Haber Shannon L Stott Mehmet Toner

PLoS One 2018 23;13(2):e0192734. Epub 2018 Feb 23.

BioMEMS Resource Center, Center for Engineering in Medicine & Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0192734PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5825040PMC
April 2018

An RNA-Based Digital Circulating Tumor Cell Signature Is Predictive of Drug Response and Early Dissemination in Prostate Cancer.

Authors:
David T Miyamoto Richard J Lee Mark Kalinich Joseph A LiCausi Yu Zheng Tianqi Chen John D Milner Erin Emmons Uyen Ho Katherine Broderick Erin Silva Sarah Javaid Tanya Todorova Kwan Xin Hong Douglas M Dahl Francis J McGovern Jason A Efstathiou Matthew R Smith Lecia V Sequist Ravi Kapur Chin-Lee Wu Shannon L Stott David T Ting Anita Giobbie-Hurder Mehmet Toner Shyamala Maheswaran Daniel A Haber

Cancer Discov 2018 03 4;8(3):288-303. Epub 2018 Jan 4.

Massachusetts General Hospital Cancer Center, Boston, Massachusetts.

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http://dx.doi.org/10.1158/2159-8290.CD-16-1406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342192PMC
March 2018

Molecular signatures of circulating melanoma cells for monitoring early response to immune checkpoint therapy.

Authors:
Xin Hong Ryan J Sullivan Mark Kalinich Tanya Todorova Kwan Anita Giobbie-Hurder Shiwei Pan Joseph A LiCausi John D Milner Linda T Nieman Ben S Wittner Uyen Ho Tianqi Chen Ravi Kapur Donald P Lawrence Keith T Flaherty Lecia V Sequist Sridhar Ramaswamy David T Miyamoto Michael Lawrence Mehmet Toner Kurt J Isselbacher Shyamala Maheswaran Daniel A Haber

Proc Natl Acad Sci U S A 2018 03 16;115(10):2467-2472. Epub 2018 Feb 16.

Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02114;

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http://dx.doi.org/10.1073/pnas.1719264115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877960PMC
March 2018

Single-Cell Analysis of Circulating Tumor Cells as a Window into Tumor Heterogeneity.

Authors:
David T Miyamoto David T Ting Mehmet Toner Shyamala Maheswaran Daniel A Haber

Cold Spring Harb Symp Quant Biol 2016 7;81:269-274. Epub 2017 Apr 7.

Massachusetts General Hospital Cancer Center, Boston, Massachusetts 02114.

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http://dx.doi.org/10.1101/sqb.2016.81.031120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501288PMC
February 2018

Cancer detection: Seeking signals in blood.

Authors:
Mark Kalinich Daniel A Haber

Science 2018 02;359(6378):866-867

Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02467, USA.

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http://dx.doi.org/10.1126/science.aas9102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469388PMC
February 2018

Improved Detection of Circulating Epithelial Cells in Patients with Intraductal Papillary Mucinous Neoplasms.

Authors:
Joseph W Franses Omer Basar Abdurrahman Kadayifci Osman Yuksel Melissa Choz Anupriya S Kulkarni Eric Tai Kevin D Vo Kshitij S Arora Niyati Desai Joseph A Licausi Mehmet Toner Shyamala Maheswaran Daniel A Haber David P Ryan William R Brugge David T Ting

Oncologist 2018 01 31;23(1):121-127. Epub 2017 Aug 31.

Cancer Center, Massachusetts General Hospital, Boston, Massachusetts, USA

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http://dx.doi.org/10.1634/theoncologist.2017-0234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5759811PMC
January 2018

Whole blood stabilization for the microfluidic isolation and molecular characterization of circulating tumor cells.

Authors:
Keith H K Wong Shannon N Tessier David T Miyamoto Kathleen L Miller Lauren D Bookstaver Thomas R Carey Cleo J Stannard Vishal Thapar Eric C Tai Kevin D Vo Erin S Emmons Haley M Pleskow Rebecca D Sandlin Lecia V Sequist David T Ting Daniel A Haber Shyamala Maheswaran Shannon L Stott Mehmet Toner

Nat Commun 2017 11 23;8(1):1733. Epub 2017 Nov 23.

BioMEMS Resource Center, Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.

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http://dx.doi.org/10.1038/s41467-017-01705-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700979PMC
November 2017

A mutational signature reveals alterations underlying deficient homologous recombination repair in breast cancer.

Authors:
Paz Polak Jaegil Kim Lior Z Braunstein Rosa Karlic Nicholas J Haradhavala Grace Tiao Daniel Rosebrock Dimitri Livitz Kirsten Kübler Kent W Mouw Atanas Kamburov Yosef E Maruvka Ignaty Leshchiner Eric S Lander Todd R Golub Aviad Zick Alexandre Orthwein Michael S Lawrence Rajbir N Batra Carlos Caldas Daniel A Haber Peter W Laird Hui Shen Leif W Ellisen Alan D D'Andrea Stephen J Chanock William D Foulkes Gad Getz

Nat Genet 2017 Oct 21;49(10):1476-1486. Epub 2017 Aug 21.

Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.3934DOI Listing
October 2017

Microfluidic isolation of platelet-covered circulating tumor cells.

Authors:
Xiaocheng Jiang Keith H K Wong Aimal H Khankhel Mahnaz Zeinali Eduardo Reategui Matthew J Phillips Xi Luo Nicola Aceto Fabio Fachin Anh N Hoang Wooseok Kim Annie E Jensen Lecia V Sequist Shyamala Maheswaran Daniel A Haber Shannon L Stott Mehmet Toner

Lab Chip 2017 10;17(20):3498-3503

Center for Engineering in Medicine, Massachusetts General Hospital & Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1039/c7lc00654cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5690580PMC
October 2017

Monolithic Chip for High-throughput Blood Cell Depletion to Sort Rare Circulating Tumor Cells.

Authors:
Fabio Fachin Philipp Spuhler Joseph M Martel-Foley Jon F Edd Thomas A Barber John Walsh Murat Karabacak Vincent Pai Melissa Yu Kyle Smith Henry Hwang Jennifer Yang Sahil Shah Ruby Yarmush Lecia V Sequist Shannon L Stott Shyamala Maheswaran Daniel A Haber Ravi Kapur Mehmet Toner

Sci Rep 2017 09 7;7(1):10936. Epub 2017 Sep 7.

BioMEMS Resource Center, Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, 02114, USA.

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http://dx.doi.org/10.1038/s41598-017-11119-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589885PMC
September 2017

A conduit to metastasis: circulating tumor cell biology.

Authors:
Douglas S Micalizzi Shyamala Maheswaran Daniel A Haber

Genes Dev 2017 09;31(18):1827-1840

Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts, 02129, USA.

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http://dx.doi.org/10.1101/gad.305805.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5695084PMC
September 2017

Clusters of Circulating Tumor Cells: a Biophysical and Technological Perspective.

Authors:
Sam H Au Jon Edd Daniel A Haber Shyamala Maheswaran Shannon L Stott Mehmet Toner

Curr Opin Biomed Eng 2017 Sep 10;3:13-19. Epub 2017 Aug 10.

Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.

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http://dx.doi.org/10.1016/j.cobme.2017.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720146PMC
September 2017

Cancer metastasis through the prism of epithelial-to-mesenchymal transition in circulating tumor cells.

Authors:
Douglas S Micalizzi Daniel A Haber Shyamala Maheswaran

Mol Oncol 2017 07 9;11(7):770-780. Epub 2017 Jun 9.

Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA, USA.

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http://dx.doi.org/10.1002/1878-0261.12081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496489PMC
July 2017

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway.

Authors:
Vasanthi S Viswanathan Matthew J Ryan Harshil D Dhruv Shubhroz Gill Ossia M Eichhoff Brinton Seashore-Ludlow Samuel D Kaffenberger John K Eaton Kenichi Shimada Andrew J Aguirre Srinivas R Viswanathan Shrikanta Chattopadhyay Pablo Tamayo Wan Seok Yang Matthew G Rees Sixun Chen Zarko V Boskovic Sarah Javaid Cherrie Huang Xiaoyun Wu Yuen-Yi Tseng Elisabeth M Roider Dong Gao James M Cleary Brian M Wolpin Jill P Mesirov Daniel A Haber Jeffrey A Engelman Jesse S Boehm Joanne D Kotz Cindy S Hon Yu Chen William C Hahn Mitchell P Levesque John G Doench Michael E Berens Alykhan F Shamji Paul A Clemons Brent R Stockwell Stuart L Schreiber

Nature 2017 07 5;547(7664):453-457. Epub 2017 Jul 5.

Broad Institute, 415 Main Street, Cambridge, Massachusetts 02142, USA.

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http://www.nature.com/doifinder/10.1038/nature23007
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http://dx.doi.org/10.1038/nature23007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5667900PMC
July 2017

Preservative solution that stabilizes erythrocyte morphology and leukocyte viability under ambient conditions.

Authors:
Rebecca D Sandlin Keith H K Wong Leo Boneschansker Thomas R Carey Kathleen L Miller Gregory Rose Daniel A Haber Shyamala Maheswaran Daniel Irimia Shannon L Stott Mehmet Toner

Sci Rep 2017 07 18;7(1):5658. Epub 2017 Jul 18.

BioMEMS Resource Center, Center for Engineering in Medicine, & Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.

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http://dx.doi.org/10.1038/s41598-017-05978-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5515929PMC
July 2017

Modeling background radiation in Southern Nevada.

Authors:
Daniel A Haber Pamela C Burnley Christopher T Adcock Russell L Malchow Kara E Marsac Elisabeth M Hausrath

J Environ Radioact 2017 May 6;171:41-64. Epub 2017 Feb 6.

University of Nevada Las Vegas, Geoscience Department, 4505 S Maryland Parkway, Las Vegas, NV, 89154, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jenvrad.2017.01.020DOI Listing
May 2017

Microfluidic Isolation of Circulating Tumor Cell Clusters by Size and Asymmetry.

Authors:
Sam H Au Jon Edd Amy E Stoddard Keith H K Wong Fabio Fachin Shyamala Maheswaran Daniel A Haber Shannon L Stott Ravi Kapur Mehmet Toner

Sci Rep 2017 05 26;7(1):2433. Epub 2017 May 26.

Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.

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http://dx.doi.org/10.1038/s41598-017-01150-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446400PMC
May 2017

Monte Carlo simulations of the gamma-ray exposure rates of common rocks.

Authors:
Daniel A Haber Russell L Malchow Pamela C Burnley

J Environ Radioact 2017 Feb 24;167:20-25. Epub 2016 Nov 24.

University of Nevada Las Vegas, Geoscience Department, 4505 S Maryland Parkway, Las Vegas, NV 89154, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jenvrad.2016.11.013DOI Listing
February 2017

Expression of β-globin by cancer cells promotes cell survival during blood-borne dissemination.

Authors:
Yu Zheng David T Miyamoto Ben S Wittner James P Sullivan Nicola Aceto Nicole Vincent Jordan Min Yu Nezihi Murat Karabacak Valentine Comaills Robert Morris Rushil Desai Niyati Desai Erin Emmons John D Milner Richard J Lee Chin-Lee Wu Lecia V Sequist Wilhelm Haas David T Ting Mehmet Toner Sridhar Ramaswamy Shyamala Maheswaran Daniel A Haber

Nat Commun 2017 02 9;8:14344. Epub 2017 Feb 9.

Massachusetts General Cancer Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1038/ncomms14344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321792PMC
February 2017

ATR inhibition disrupts rewired homologous recombination and fork protection pathways in PARP inhibitor-resistant BRCA-deficient cancer cells.

Authors:
Stephanie A Yazinski Valentine Comaills Rémi Buisson Marie-Michelle Genois Hai Dang Nguyen Chu Kwen Ho Tanya Todorova Kwan Robert Morris Sam Lauffer André Nussenzweig Sridhar Ramaswamy Cyril H Benes Daniel A Haber Shyamala Maheswaran Michael J Birrer Lee Zou

Genes Dev 2017 02 27;31(3):318-332. Epub 2017 Feb 27.

Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1101/gad.290957.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358727PMC
February 2017

An RNA-based signature enables high specificity detection of circulating tumor cells in hepatocellular carcinoma.

Authors:
Mark Kalinich Irun Bhan Tanya T Kwan David T Miyamoto Sarah Javaid Joseph A LiCausi John D Milner Xin Hong Lipika Goyal Srinjoy Sil Melissa Choz Uyen Ho Ravi Kapur Alona Muzikansky Huidan Zhang David A Weitz Lecia V Sequist David P Ryan Raymond T Chung Andrew X Zhu Kurt J Isselbacher David T Ting Mehmet Toner Shyamala Maheswaran Daniel A Haber

Proc Natl Acad Sci U S A 2017 01 17;114(5):1123-1128. Epub 2017 Jan 17.

Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129;

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http://dx.doi.org/10.1073/pnas.1617032114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5293050PMC
January 2017

Modeling background radiation using geochemical data: A case study in and around Cameron, Arizona.

Authors:
Kara E Marsac Pamela C Burnley Christopher T Adcock Daniel A Haber Russell L Malchow Elisabeth M Hausrath

J Environ Radioact 2016 Dec 16;165:68-85. Epub 2016 Sep 16.

University of Nevada Las Vegas, Geoscience Department, 4505 S Maryland Parkway, Las Vegas, NV 89154, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jenvrad.2016.07.012DOI Listing
December 2016

Genomic Instability Is Induced by Persistent Proliferation of Cells Undergoing Epithelial-to-Mesenchymal Transition.

Authors:
Valentine Comaills Lilian Kabeche Robert Morris Rémi Buisson Min Yu Marissa Wells Madden Joseph A LiCausi Myriam Boukhali Ken Tajima Shiwei Pan Nicola Aceto Srinjoy Sil Yu Zheng Tilak Sundaresan Toshifumi Yae Nicole Vincent Jordan David T Miyamoto David T Ting Sridhar Ramaswamy Wilhelm Haas Lee Zou Daniel A Haber Shyamala Maheswaran

Cell Rep 2016 12;17(10):2632-2647

Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA; Department of Surgery, Harvard Medical School, Charlestown, MA 02129, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.11.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5320932PMC
December 2016

HER2 expression identifies dynamic functional states within circulating breast cancer cells.

Authors:
Nicole Vincent Jordan Aditya Bardia Ben S Wittner Cyril Benes Matteo Ligorio Yu Zheng Min Yu Tilak K Sundaresan Joseph A Licausi Rushil Desai Ryan M O'Keefe Richard Y Ebright Myriam Boukhali Srinjoy Sil Maristela L Onozato Anthony J Iafrate Ravi Kapur Dennis Sgroi David T Ting Mehmet Toner Sridhar Ramaswamy Wilhelm Haas Shyamala Maheswaran Daniel A Haber

Nature 2016 09 24;537(7618):102-106. Epub 2016 Aug 24.

Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1038/nature19328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5161614PMC
September 2016

A tunable delivery platform to provide local chemotherapy for pancreatic ductal adenocarcinoma.

Authors:
Laura Indolfi Matteo Ligorio David T Ting Kristina Xega Abraham R Tzafriri Francesca Bersani Nicola Aceto Vishal Thapar Bryan C Fuchs Vikram Deshpande Aaron B Baker Cristina R Ferrone Daniel A Haber Robert Langer Jeffrey W Clark Elazer R Edelman

Biomaterials 2016 07 31;93:71-82. Epub 2016 Mar 31.

Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA; Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.biomaterials.2016.03.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849535PMC
July 2016

A Landscape of Pharmacogenomic Interactions in Cancer.

Authors:
Francesco Iorio Theo A Knijnenburg Daniel J Vis Graham R Bignell Michael P Menden Michael Schubert Nanne Aben Emanuel Gonçalves Syd Barthorpe Howard Lightfoot Thomas Cokelaer Patricia Greninger Ewald van Dyk Han Chang Heshani de Silva Holger Heyn Xianming Deng Regina K Egan Qingsong Liu Tatiana Mironenko Xeni Mitropoulos Laura Richardson Jinhua Wang Tinghu Zhang Sebastian Moran Sergi Sayols Maryam Soleimani David Tamborero Nuria Lopez-Bigas Petra Ross-Macdonald Manel Esteller Nathanael S Gray Daniel A Haber Michael R Stratton Cyril H Benes Lodewyk F A Wessels Julio Saez-Rodriguez Ultan McDermott Mathew J Garnett

Cell 2016 Jul 7;166(3):740-754. Epub 2016 Jul 7.

Wellcome Trust Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.06.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967469PMC
July 2016

Landscape of Targeted Anti-Cancer Drug Synergies in Melanoma Identifies a Novel BRAF-VEGFR/PDGFR Combination Treatment.

Authors:
Adam A Friedman Arnaud Amzallag Iulian Pruteanu-Malinici Subash Baniya Zachary A Cooper Adriano Piris Leeza Hargreaves Vivien Igras Dennie T Frederick Donald P Lawrence Daniel A Haber Keith T Flaherty Jennifer A Wargo Sridhar Ramaswamy Cyril H Benes David E Fisher

PLoS One 2015 13;10(10):e0140310. Epub 2015 Oct 13.

Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts, United States of America; Dermatology and Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604168PMC
June 2016

Clusters of circulating tumor cells traverse capillary-sized vessels.

Authors:
Sam H Au Brian D Storey John C Moore Qin Tang Yeng-Long Chen Sarah Javaid A Fatih Sarioglu Ryan Sullivan Marissa W Madden Ryan O'Keefe Daniel A Haber Shyamala Maheswaran David M Langenau Shannon L Stott Mehmet Toner

Proc Natl Acad Sci U S A 2016 May 18;113(18):4947-52. Epub 2016 Apr 18.

Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114; Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114; Shriners Hospital for Children, Boston, MA 02114

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http://dx.doi.org/10.1073/pnas.1524448113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4983862PMC
May 2016

Genome Sequencing of Multiple Primary Tumors Reveals a Novel PALB2 Variant.

Authors:
Kasmintan A Schrader Kelly L Stratton Rajmohan Murali Yael Laitman Luca Cavallone Lily Offit Yong Hannah Wen Tinu Thomas Sohela Shah Rohini Rau-Murthy Christopher Manschreck Erin Salo-Mullen Ebun Otegbeye Marina Corines Liying Zhang Larry Norton Clifford Hudis Robert J Klein Noah D Kauff Mark Robson Zsofia K Stadler Daniel A Haber Steven M Lipkin Eitan Friedman William D Foulkes David Altshuler Joseph Vijai Kenneth Offit

J Clin Oncol 2016 Mar 30;34(8):e61-7. Epub 2014 Jun 30.

Memorial Sloan Kettering Cancer Center, New York, NY

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http://dx.doi.org/10.1200/JCO.2013.50.0272DOI Listing
March 2016

Detection of T790M, the Acquired Resistance EGFR Mutation, by Tumor Biopsy versus Noninvasive Blood-Based Analyses.

Authors:
Tilak K Sundaresan Lecia V Sequist John V Heymach Gregory J Riely Pasi A Jänne Walter H Koch James P Sullivan Douglas B Fox Robert Maher Alona Muzikansky Andrew Webb Hai T Tran Uma Giri Martin Fleisher Helena A Yu Wen Wei Bruce E Johnson Thomas A Barber John R Walsh Jeffrey A Engelman Shannon L Stott Ravi Kapur Shyamala Maheswaran Mehmet Toner Daniel A Haber

Clin Cancer Res 2016 Mar 7;22(5):1103-10. Epub 2015 Oct 7.

Massachusetts General Hospital Cancer Center, Boston, Massachusetts. Department of Medicine, Harvard Medical School, Boston, Massachusetts. Howard Hughes Medical Institute, Chevy Chase, Maryland.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-1031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4775471PMC
March 2016

Correlating chemical sensitivity and basal gene expression reveals mechanism of action.

Authors:
Matthew G Rees Brinton Seashore-Ludlow Jaime H Cheah Drew J Adams Edmund V Price Shubhroz Gill Sarah Javaid Matthew E Coletti Victor L Jones Nicole E Bodycombe Christian K Soule Benjamin Alexander Ava Li Philip Montgomery Joanne D Kotz C Suk-Yee Hon Benito Munoz Ted Liefeld Vlado Dančík Daniel A Haber Clary B Clish Joshua A Bittker Michelle Palmer Bridget K Wagner Paul A Clemons Alykhan F Shamji Stuart L Schreiber

Nat Chem Biol 2016 Feb 14;12(2):109-16. Epub 2015 Dec 14.

Broad Institute, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/nchembio.1986DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718762PMC
February 2016

The Role of Physical Stabilization in Whole Blood Preservation.

Authors:
Keith H K Wong Rebecca D Sandlin Thomas R Carey Kathleen L Miller Aaron T Shank Rahmi Oklu Shyamala Maheswaran Daniel A Haber Daniel Irimia Shannon L Stott Mehmet Toner

Sci Rep 2016 Feb 15;6:21023. Epub 2016 Feb 15.

BioMEMS Resource Center, Center for Engineering in Medicine, &Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1038/srep21023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4753451PMC
February 2016

Pericentromeric satellite repeat expansions through RNA-derived DNA intermediates in cancer.

Authors:
Francesca Bersani Eunjung Lee Peter V Kharchenko Andrew W Xu Mingzhu Liu Kristina Xega Olivia C MacKenzie Brian W Brannigan Ben S Wittner Hyunchul Jung Sridhar Ramaswamy Peter J Park Shyamala Maheswaran David T Ting Daniel A Haber

Proc Natl Acad Sci U S A 2015 Dec 2;112(49):15148-53. Epub 2015 Nov 2.

Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129; Howard Hughes Medical Institute, Chevy Chase, MD 20815; Department of Medicine, Massachusetts General Hospital, Boston, MA 02114;

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http://dx.doi.org/10.1073/pnas.1518008112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4679016PMC
December 2015

Fantastic voyage: the future of cancer diagnostics.

Authors:
Tilak K Sundaresan Daniel A Haber

Lancet Oncol 2015 Dec;16(16):1596-8

Massachusetts General Hospital Cancer Center, Harvard Medical School and Howard Hughes Medical Institute, Boston, MA 02129, USA. Electronic address:

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http://dx.doi.org/10.1016/S1470-2045(15)00469-6DOI Listing
December 2015

Cell fate: Transition loses its invasive edge.

Authors:
Shyamala Maheswaran Daniel A Haber

Nature 2015 Nov 11;527(7579):452-3. Epub 2015 Nov 11.

Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1038/nature16313DOI Listing
November 2015

Biodegradable nano-films for capture and non-invasive release of circulating tumor cells.

Authors:
Wei Li Eduardo Reátegui Myoung-Hwan Park Steven Castleberry Jason Z Deng Bryan Hsu Sarah Mayner Anne E Jensen Lecia V Sequist Shyamala Maheswaran Daniel A Haber Mehmet Toner Shannon L Stott Paula T Hammond

Biomaterials 2015 Oct 20;65:93-102. Epub 2015 Jun 20.

Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.

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http://dx.doi.org/10.1016/j.biomaterials.2015.06.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827098PMC
October 2015

En Route to Metastasis: Circulating Tumor Cell Clusters and Epithelial-to-Mesenchymal Transition.

Authors:
Nicola Aceto Mehmet Toner Shyamala Maheswaran Daniel A Haber

Trends Cancer 2015 Sep 28;1(1):44-52. Epub 2015 Sep 28.

Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02129, USA; Department of Medicine, Harvard Medical School, Boston, MA 02129, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA. Electronic address:

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http://dx.doi.org/10.1016/j.trecan.2015.07.006DOI Listing
September 2015

RNA-Seq of single prostate CTCs implicates noncanonical Wnt signaling in antiandrogen resistance.

Authors:
David T Miyamoto Yu Zheng Ben S Wittner Richard J Lee Huili Zhu Katherine T Broderick Rushil Desai Douglas B Fox Brian W Brannigan Julie Trautwein Kshitij S Arora Niyati Desai Douglas M Dahl Lecia V Sequist Matthew R Smith Ravi Kapur Chin-Lee Wu Toshi Shioda Sridhar Ramaswamy David T Ting Mehmet Toner Shyamala Maheswaran Daniel A Haber

Science 2015 Sep;349(6254):1351-6

Massachusetts General Cancer Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA. Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA. Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1126/science.aab0917DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872391PMC
September 2015

SETD1A modulates cell cycle progression through a miRNA network that regulates p53 target genes.

Authors:
Ken Tajima Toshifumi Yae Sarah Javaid Oliver Tam Valentine Comaills Robert Morris Ben S Wittner Mingzhu Liu Amanda Engstrom Fumiyuki Takahashi Joshua C Black Sridhar Ramaswamy Toshihiro Shioda Molly Hammell Daniel A Haber Johnathan R Whetstine Shyamala Maheswaran

Nat Commun 2015 Sep 23;6:8257. Epub 2015 Sep 23.

Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts 02129, USA.

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http://www.nature.com/articles/ncomms9257
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http://dx.doi.org/10.1038/ncomms9257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4667427PMC
September 2015

A computational study of circulating large tumor cells traversing microvessels.

Authors:
Nikola Kojić Miljan Milošević Dejan Petrović Velibor Isailović A Fatih Sarioglu Daniel A Haber Miloš Kojić Mehmet Toner

Comput Biol Med 2015 Aug 10;63:187-95. Epub 2015 Jun 10.

Department of Surgery and Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, and Shriners Hospitals for Children, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.compbiomed.2015.05.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819961PMC
August 2015

Does molecular monitoring matter in early-stage breast cancer?

Authors:
Tilak K Sundaresan Daniel A Haber

Sci Transl Med 2015 Aug;7(302):302fs35

Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02129, USA. Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.

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http://stm.sciencemag.org/content/scitransmed/7/302/302fs35.
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http://dx.doi.org/10.1126/scitranslmed.aac9445DOI Listing
August 2015

A microfluidic device for label-free, physical capture of circulating tumor cell clusters.

Authors:
A Fatih Sarioglu Nicola Aceto Nikola Kojic Maria C Donaldson Mahnaz Zeinali Bashar Hamza Amanda Engstrom Huili Zhu Tilak K Sundaresan David T Miyamoto Xi Luo Aditya Bardia Ben S Wittner Sridhar Ramaswamy Toshi Shioda David T Ting Shannon L Stott Ravi Kapur Shyamala Maheswaran Daniel A Haber Mehmet Toner

Nat Methods 2015 Jul 18;12(7):685-91. Epub 2015 May 18.

1] Center for Engineering in Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA. [2] Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nmeth.3404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490017PMC
July 2015

The WTX Tumor Suppressor Interacts with the Transcriptional Corepressor TRIM28.

Authors:
Woo Jae Kim Ben S Wittner Arnaud Amzallag Brian W Brannigan David T Ting Sridhar Ramaswamy Shyamala Maheswaran Daniel A Haber

J Biol Chem 2015 Jun 16;290(23):14381-90. Epub 2015 Apr 16.

Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, Massachusetts 02129 and From the Departments of Medicine and Howard Hughes Medical Institute, Chevy Chase, Maryland 20815

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http://dx.doi.org/10.1074/jbc.M114.631945DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505506PMC
June 2015

Ex Vivo Culture of CTCs: An Emerging Resource to Guide Cancer Therapy.

Authors:
Shyamala Maheswaran Daniel A Haber

Cancer Res 2015 Jun 21;75(12):2411-5. Epub 2015 May 21.

Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, Massachusetts. Howard Hughes Medical Institute, Chevy Chase, Maryland.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-0145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4470788PMC
June 2015

Continuous Flow Microfluidic Bioparticle Concentrator.

Authors:
Joseph M Martel Kyle C Smith Mcolisi Dlamini Kendall Pletcher Jennifer Yang Murat Karabacak Daniel A Haber Ravi Kapur Mehmet Toner

Sci Rep 2015 Jun 10;5:11300. Epub 2015 Jun 10.

1] BioMEMS Resource Center, Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, 02114, USA [2] Shriners Hospital for Children, Boston, Massachusetts, 02114, USA.

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http://dx.doi.org/10.1038/srep11300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4462155PMC
June 2015

MAPK7 Regulates EMT Features and Modulates the Generation of CTCs.

Authors:
Sarah Javaid Jianmin Zhang Gromoslaw A Smolen Min Yu Ben S Wittner Anurag Singh Kshitij S Arora Marissa W Madden Rushil Desai Matthew J Zubrowski Benjamin J Schott David T Ting Shannon L Stott Mehmet Toner Shyamala Maheswaran Toshi Shioda Sridhar Ramaswamy Daniel A Haber

Mol Cancer Res 2015 May 12;13(5):934-43. Epub 2015 Feb 12.

Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, Massachusetts. Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts. Howard Hughes Medical Institute, Chevy Chase, Maryland.

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http://dx.doi.org/10.1158/1541-7786.MCR-14-0604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433453PMC
May 2015

Tunable nanostructured coating for the capture and selective release of viable circulating tumor cells.

Authors:
Eduardo Reátegui Nicola Aceto Eugene J Lim James P Sullivan Anne E Jensen Mahnaz Zeinali Joseph M Martel Alexander J Aranyosi Wei Li Steven Castleberry Aditya Bardia Lecia V Sequist Daniel A Haber Shyamala Maheswaran Paula T Hammond Mehmet Toner Shannon L Stott

Adv Mater 2015 Mar 15;27(9):1593-9. Epub 2015 Jan 15.

Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, Building 114, 16th Street, Charlestown, MA, 02129, USA; Shriners Hospital for Children, Harvard Medical School, 51 Blossom Street, Boston, MA, 02114, USA; Department of Surgery, Massachusetts General Hospital, Harvard Medical School 55, 55 Fruit Street, Boston, MA, 02114, USA.

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http://dx.doi.org/10.1002/adma.201404677DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492283PMC
March 2015

Inhibition of mutant EGFR in lung cancer cells triggers SOX2-FOXO6-dependent survival pathways.

Authors:
S Michael Rothenberg Kyle Concannon Sarah Cullen Gaylor Boulay Alexa B Turke Anthony C Faber Elizabeth L Lockerman Miguel N Rivera Jeffrey A Engelman Shyamala Maheswaran Daniel A Haber

Elife 2015 Feb 16;4. Epub 2015 Feb 16.

Cancer Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, United States.

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http://publishing-cdn.elifesciences.org/06132/elife-06132-v2
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http://elifesciences.org/lookup/doi/10.7554/eLife.06132
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http://dx.doi.org/10.7554/eLife.06132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4384750PMC
February 2015

Alternative lengthening of telomeres renders cancer cells hypersensitive to ATR inhibitors.

Authors:
Rachel Litman Flynn Kelli E Cox Maya Jeitany Hiroaki Wakimoto Alysia R Bryll Neil J Ganem Francesca Bersani Jose R Pineda Mario L Suvà Cyril H Benes Daniel A Haber Francois D Boussin Lee Zou

Science 2015 Jan;347(6219):273-7

Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA. Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1126/science.1257216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4358324PMC
January 2015

Bioengineered implantable scaffolds as a tool to study stromal-derived factors in metastatic cancer models.

Authors:
Francesca Bersani Jungwoo Lee Min Yu Robert Morris Rushil Desai Sridhar Ramaswamy Mehmet Toner Daniel A Haber Biju Parekkadan

Cancer Res 2014 Dec 22;74(24):7229-38. Epub 2014 Oct 22.

Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School and the Shriners Hospitals for Children, Boston, Massachusetts. Harvard Stem Cell Institute, Boston, Massachusetts.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-1809DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267901PMC
December 2014

Visnagin protects against doxorubicin-induced cardiomyopathy through modulation of mitochondrial malate dehydrogenase.

Authors:
Yan Liu Aarti Asnani Lin Zou Victoria L Bentley Min Yu You Wang Graham Dellaire Kumar S Sarkar Matthew Dai Howard H Chen David E Sosnovik Jordan T Shin Daniel A Haber Jason N Berman Wei Chao Randall T Peterson

Sci Transl Med 2014 Dec;6(266):266ra170

Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA. Broad Institute, Cambridge, MA 02142, USA.

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http://stm.sciencemag.org/cgi/doi/10.1126/scitranslmed.30101
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http://dx.doi.org/10.1126/scitranslmed.3010189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4360984PMC
December 2014

Solidifying liquid biopsies: can circulating tumor cell monitoring guide treatment selection in breast cancer?

Authors:
Aditya Bardia Daniel A Haber

J Clin Oncol 2014 Nov 14;32(31):3470-1. Epub 2014 Jul 14.

Massachusetts General Hospital Cancer Center; Harvard Medical School, Boston, MA

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http://dx.doi.org/10.1200/JCO.2014.57.1505DOI Listing
November 2014

Collective and individual migration following the epithelial-mesenchymal transition.

Authors:
Ian Y Wong Sarah Javaid Elisabeth A Wong Sinem Perk Daniel A Haber Mehmet Toner Daniel Irimia

Nat Mater 2014 Nov 17;13(11):1063-71. Epub 2014 Aug 17.

BioMEMS Resource Center, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1038/nmat4062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209198PMC
November 2014

Brain tumor cells in circulation are enriched for mesenchymal gene expression.

Authors:
James P Sullivan Brian V Nahed Marissa W Madden Samantha M Oliveira Simeon Springer Deepak Bhere Andrew S Chi Hiroaki Wakimoto S Michael Rothenberg Lecia V Sequist Ravi Kapur Khalid Shah A John Iafrate William T Curry Jay S Loeffler Tracy T Batchelor David N Louis Mehmet Toner Shyamala Maheswaran Daniel A Haber

Cancer Discov 2014 Nov 19;4(11):1299-309. Epub 2014 Aug 19.

Massachusetts General Hospital Cancer Center, Boston, Massachusetts. Department of Medicine, Harvard Medical School, Boston, Massachusetts. Howard Hughes Medical Institute, Chevy Chase, Maryland.

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http://dx.doi.org/10.1158/2159-8290.CD-14-0471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4221467PMC
November 2014

Phase II study of olaparib in patients with refractory Ewing sarcoma following failure of standard chemotherapy.

Authors:
Edwin Choy James E Butrynski David C Harmon Jeffrey A Morgan Suzanne George Andrew J Wagner David D'Adamo Gregory M Cote Yael Flamand Cyril H Benes Daniel A Haber Jose M Baselga George D Demetri

BMC Cancer 2014 Nov 5;14:813. Epub 2014 Nov 5.

Division of Hematology Oncology, Massachusetts General Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1186/1471-2407-14-813DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230717PMC
November 2014

Single-cell RNA sequencing identifies extracellular matrix gene expression by pancreatic circulating tumor cells.

Authors:
David T Ting Ben S Wittner Matteo Ligorio Nicole Vincent Jordan Ajay M Shah David T Miyamoto Nicola Aceto Francesca Bersani Brian W Brannigan Kristina Xega Jordan C Ciciliano Huili Zhu Olivia C MacKenzie Julie Trautwein Kshitij S Arora Mohammad Shahid Haley L Ellis Na Qu Nabeel Bardeesy Miguel N Rivera Vikram Deshpande Cristina R Ferrone Ravi Kapur Sridhar Ramaswamy Toshi Shioda Mehmet Toner Shyamala Maheswaran Daniel A Haber

Cell Rep 2014 Sep 18;8(6):1905-1918. Epub 2014 Sep 18.

Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02114, USA; Department of Medicine, Harvard Medical School, Boston, MA 02114, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA. Electronic address:

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http://www.cell.com/cms/attachment/2020605915/2040322195/mmc
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http://linkinghub.elsevier.com/retrieve/pii/S221112471400705
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http://dx.doi.org/10.1016/j.celrep.2014.08.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230325PMC
September 2014

Circulating tumor cell clusters are oligoclonal precursors of breast cancer metastasis.

Authors:
Nicola Aceto Aditya Bardia David T Miyamoto Maria C Donaldson Ben S Wittner Joel A Spencer Min Yu Adam Pely Amanda Engstrom Huili Zhu Brian W Brannigan Ravi Kapur Shannon L Stott Toshi Shioda Sridhar Ramaswamy David T Ting Charles P Lin Mehmet Toner Daniel A Haber Shyamala Maheswaran

Cell 2014 Aug;158(5):1110-1122

Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02129, USA; Department of Surgery, Harvard Medical School, Boston, MA 02129, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.07.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4149753PMC
August 2014

A zebrafish model of chordoma initiated by notochord-driven expression of HRASV12.

Authors:
Alexa Burger Aleksandr Vasilyev Ritu Tomar Martin K Selig G Petur Nielsen Randall T Peterson Iain A Drummond Daniel A Haber

Dis Model Mech 2014 Jul 5;7(7):907-13. Epub 2013 Dec 5.

Cancer Center, Massachusetts General Hospital, Charlestown, MA 02129, USA. Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.

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http://dx.doi.org/10.1242/dmm.013128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073279PMC
July 2014

Cancer therapy. Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility.

Authors:
Min Yu Aditya Bardia Nicola Aceto Francesca Bersani Marissa W Madden Maria C Donaldson Rushil Desai Huili Zhu Valentine Comaills Zongli Zheng Ben S Wittner Petar Stojanov Elena Brachtel Dennis Sgroi Ravi Kapur Toshihiro Shioda David T Ting Sridhar Ramaswamy Gad Getz A John Iafrate Cyril Benes Mehmet Toner Shyamala Maheswaran Daniel A Haber

Science 2014 Jul;345(6193):216-20

Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA. Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA. Department of Medicine, Harvard Medical School, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1126/science.1253533DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4358808PMC
July 2014

Blood-based analyses of cancer: circulating tumor cells and circulating tumor DNA.

Authors:
Daniel A Haber Victor E Velculescu

Cancer Discov 2014 Jun 6;4(6):650-61. Epub 2014 May 6.

Authors' Affiliations:Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts; Howard Hughes Medical Institute, Chevy Chase; and Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland

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http://dx.doi.org/10.1158/2159-8290.CD-13-1014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433544PMC
June 2014

Isolation and molecular characterization of circulating melanoma cells.

Authors:
Xi Luo Devarati Mitra Ryan J Sullivan Ben S Wittner Anya M Kimura Shiwei Pan Mai P Hoang Brian W Brannigan Donald P Lawrence Keith T Flaherty Lecia V Sequist Martin McMahon Marcus W Bosenberg Shannon L Stott David T Ting Sridhar Ramaswamy Mehmet Toner David E Fisher Shyamala Maheswaran Daniel A Haber

Cell Rep 2014 May 18;7(3):645-53. Epub 2014 Apr 18.

Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA; Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Howard Hughes Medical Institute, Bethesda, MD 20815, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.03.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4079008PMC
May 2014

Microfluidic, marker-free isolation of circulating tumor cells from blood samples.

Authors:
Nezihi Murat Karabacak Philipp S Spuhler Fabio Fachin Eugene J Lim Vincent Pai Emre Ozkumur Joseph M Martel Nikola Kojic Kyle Smith Pin-i Chen Jennifer Yang Henry Hwang Bailey Morgan Julie Trautwein Thomas A Barber Shannon L Stott Shyamala Maheswaran Ravi Kapur Daniel A Haber Mehmet Toner

Nat Protoc 2014 Mar 27;9(3):694-710. Epub 2014 Feb 27.

Department of Surgery and Center for Engineering in Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nprot.2014.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4179254PMC
March 2014

Inactivation of the tumor suppressor WTX in a subset of pediatric tumors.

Authors:
Sara Akhavanfard Sara O Vargas Moonjoo Han Mai Nitta Clarice B Chang Long P Le Ladan Fazlollahi Quan Nguyen Yunqing Ma Arjola Cosper Dora Dias-Santagata Jae Y Han Kristin Bergethon Darrell R Borger Leif W Ellisen Scott L Pomeroy Daniel A Haber A John Iafrate Miguel N Rivera

Genes Chromosomes Cancer 2014 Jan 5;53(1):67-77. Epub 2013 Nov 5.

Department of Pathology, Massachusetts General Hospital, Boston, MA; Cancer Center, Massachusetts General Hospital, Boston, MA; Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1002/gcc.22118DOI Listing
January 2014

The IGF2 intronic miR-483 selectively enhances transcription from IGF2 fetal promoters and enhances tumorigenesis.

Authors:
Mingzhu Liu Anna Roth Min Yu Robert Morris Francesca Bersani Miguel N Rivera Jun Lu Toshihiro Shioda Shobha Vasudevan Sridhar Ramaswamy Shyamala Maheswaran Sven Diederichs Daniel A Haber

Genes Dev 2013 Dec;27(23):2543-8

Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts 02129, USA;

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http://dx.doi.org/10.1101/gad.224170.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861668PMC
December 2013

Dynamic chromatin modification sustains epithelial-mesenchymal transition following inducible expression of Snail-1.

Authors:
Sarah Javaid Jianmin Zhang Endre Anderssen Josh C Black Ben S Wittner Ken Tajima David T Ting Gromoslaw A Smolen Matthew Zubrowski Rushil Desai Shyamala Maheswaran Sridhar Ramaswamy Johnathan R Whetstine Daniel A Haber

Cell Rep 2013 Dec 19;5(6):1679-89. Epub 2013 Dec 19.

Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, MA 02129, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2013.11.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034764PMC
December 2013

Developing standards for breakthrough therapy designation in oncology.

Authors:
Sandra J Horning Daniel A Haber Wendy K D Selig S Percy Ivy Samantha A Roberts Jeff D Allen Ellen V Sigal Charles L Sawyers

Clin Cancer Res 2013 Aug 29;19(16):4297-304. Epub 2013 May 29.

Genentech, San Francisco, California, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-0523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3745545PMC
August 2013

TORC1 suppression predicts responsiveness to RAF and MEK inhibition in BRAF-mutant melanoma.

Authors:
Ryan B Corcoran Stephen Michael Rothenberg Aaron N Hata Anthony C Faber Adriano Piris Rosalynn M Nazarian Ronald D Brown Jason T Godfrey Daniel Winokur John Walsh Mari Mino-Kenudson Shyamala Maheswaran Jeffrey Settleman Jennifer A Wargo Keith T Flaherty Daniel A Haber Jeffrey A Engelman

Sci Transl Med 2013 Jul;5(196):196ra98

Massachusetts General Hospital Cancer Center, Boston, MA 02129, USA.

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http://dx.doi.org/10.1126/scitranslmed.3005753DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867020PMC
July 2013

A dose-ranging study of cabozantinib in men with castration-resistant prostate cancer and bone metastases.

Authors:
Richard J Lee Philip J Saylor M Dror Michaelson S Michael Rothenberg Malgorzata E Smas David T Miyamoto Carol A Gurski Wanling Xie Shyamala Maheswaran Daniel A Haber Jonathan G Goldin Matthew R Smith

Clin Cancer Res 2013 Jun 3;19(11):3088-94. Epub 2013 Apr 3.

Massachusetts General Hospital Cancer Center, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-0319DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3684567PMC
June 2013

Inertial focusing for tumor antigen-dependent and -independent sorting of rare circulating tumor cells.

Authors:
Emre Ozkumur Ajay M Shah Jordan C Ciciliano Benjamin L Emmink David T Miyamoto Elena Brachtel Min Yu Pin-i Chen Bailey Morgan Julie Trautwein Anya Kimura Sudarshana Sengupta Shannon L Stott Nezihi Murat Karabacak Thomas A Barber John R Walsh Kyle Smith Philipp S Spuhler James P Sullivan Richard J Lee David T Ting Xi Luo Alice T Shaw Aditya Bardia Lecia V Sequist David N Louis Shyamala Maheswaran Ravi Kapur Daniel A Haber Mehmet Toner

Sci Transl Med 2013 Apr;5(179):179ra47

Massachusetts General Hospital Center for Engineering in Medicine, Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1126/scitranslmed.3005616DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760275PMC
April 2013

Circulating breast tumor cells exhibit dynamic changes in epithelial and mesenchymal composition.

Authors:
Min Yu Aditya Bardia Ben S Wittner Shannon L Stott Malgorzata E Smas David T Ting Steven J Isakoff Jordan C Ciciliano Marissa N Wells Ajay M Shah Kyle F Concannon Maria C Donaldson Lecia V Sequist Elena Brachtel Dennis Sgroi Jose Baselga Sridhar Ramaswamy Mehmet Toner Daniel A Haber Shyamala Maheswaran

Science 2013 Feb;339(6119):580-4

Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1126/science.1228522DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760262PMC
February 2013

Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells.

Authors:
Wanjuan Yang Jorge Soares Patricia Greninger Elena J Edelman Howard Lightfoot Simon Forbes Nidhi Bindal Dave Beare James A Smith I Richard Thompson Sridhar Ramaswamy P Andrew Futreal Daniel A Haber Michael R Stratton Cyril Benes Ultan McDermott Mathew J Garnett

Nucleic Acids Res 2013 Jan 23;41(Database issue):D955-61. Epub 2012 Nov 23.

Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK.

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http://dx.doi.org/10.1093/nar/gks1111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531057PMC
January 2013

Androgen receptor signaling in circulating tumor cells as a marker of hormonally responsive prostate cancer.

Authors:
David T Miyamoto Richard J Lee Shannon L Stott David T Ting Ben S Wittner Matthew Ulman Malgorzata E Smas Jenna B Lord Brian W Brannigan Julie Trautwein Neil H Bander Chin-Lee Wu Lecia V Sequist Matthew R Smith Sridhar Ramaswamy Mehmet Toner Shyamala Maheswaran Daniel A Haber

Cancer Discov 2012 Nov 23;2(11):995-1003. Epub 2012 Oct 23.

Massachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1158/2159-8290.CD-12-0222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3508523PMC
November 2012

An ultraviolet-radiation-independent pathway to melanoma carcinogenesis in the red hair/fair skin background.

Authors:
Devarati Mitra Xi Luo Ann Morgan Jin Wang Mai P Hoang Jennifer Lo Candace R Guerrero Jochen K Lennerz Martin C Mihm Jennifer A Wargo Kathleen C Robinson Suprabha P Devi Jillian C Vanover John A D'Orazio Martin McMahon Marcus W Bosenberg Kevin M Haigis Daniel A Haber Yinsheng Wang David E Fisher

Nature 2012 Nov 31;491(7424):449-53. Epub 2012 Oct 31.

Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1038/nature11624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521494PMC
November 2012

RNA sequencing of pancreatic circulating tumour cells implicates WNT signalling in metastasis.

Authors:
Min Yu David T Ting Shannon L Stott Ben S Wittner Fatih Ozsolak Suchismita Paul Jordan C Ciciliano Malgorzata E Smas Daniel Winokur Anna J Gilman Matthew J Ulman Kristina Xega Gianmarco Contino Brinda Alagesan Brian W Brannigan Patrice M Milos David P Ryan Lecia V Sequist Nabeel Bardeesy Sridhar Ramaswamy Mehmet Toner Shyamala Maheswaran Daniel A Haber

Nature 2012 Jul;487(7408):510-3

Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1038/nature11217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408856PMC
July 2012

Biopolymer system for cell recovery from microfluidic cell capture devices.

Authors:
Ajay M Shah Min Yu Zev Nakamura Jordan Ciciliano Matthew Ulman Kenneth Kotz Shannon L Stott Shyamala Maheswaran Daniel A Haber Mehmet Toner

Anal Chem 2012 Apr 3;84(8):3682-8. Epub 2012 Apr 3.

Harvard-MIT Division of Health Sciences and Technology, Massachussets Institute of Technology, Cambridge, Massachusetts 02139, United States.

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http://dx.doi.org/10.1021/ac300190jDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328665PMC
April 2012

The WTX tumor suppressor enhances p53 acetylation by CBP/p300.

Authors:
Woo Jae Kim Miguel N Rivera Erik J Coffman Daniel A Haber

Mol Cell 2012 Mar 26;45(5):587-97. Epub 2012 Jan 26.

Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1016/j.molcel.2011.12.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310179PMC
March 2012

Systematic identification of genomic markers of drug sensitivity in cancer cells.

Authors:
Mathew J Garnett Elena J Edelman Sonja J Heidorn Chris D Greenman Anahita Dastur King Wai Lau Patricia Greninger I Richard Thompson Xi Luo Jorge Soares Qingsong Liu Francesco Iorio Didier Surdez Li Chen Randy J Milano Graham R Bignell Ah T Tam Helen Davies Jesse A Stevenson Syd Barthorpe Stephen R Lutz Fiona Kogera Karl Lawrence Anne McLaren-Douglas Xeni Mitropoulos Tatiana Mironenko Helen Thi Laura Richardson Wenjun Zhou Frances Jewitt Tinghu Zhang Patrick O'Brien Jessica L Boisvert Stacey Price Wooyoung Hur Wanjuan Yang Xianming Deng Adam Butler Hwan Geun Choi Jae Won Chang Jose Baselga Ivan Stamenkovic Jeffrey A Engelman Sreenath V Sharma Olivier Delattre Julio Saez-Rodriguez Nathanael S Gray Jeffrey Settleman P Andrew Futreal Daniel A Haber Michael R Stratton Sridhar Ramaswamy Ultan McDermott Cyril H Benes

Nature 2012 Mar 28;483(7391):570-5. Epub 2012 Mar 28.

Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK.

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http://dx.doi.org/10.1038/nature11005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3349233PMC
March 2012

Homeobox B9 induces epithelial-to-mesenchymal transition-associated radioresistance by accelerating DNA damage responses.

Authors:
Naokazu Chiba Valentine Comaills Bunsyo Shiotani Fumiyuki Takahashi Toshiyuki Shimada Ken Tajima Daniel Winokur Tetsu Hayashida Henning Willers Elena Brachtel Maria D M Vivanco Daniel A Haber Lee Zou Shyamala Maheswaran

Proc Natl Acad Sci U S A 2012 Feb 19;109(8):2760-5. Epub 2011 Sep 19.

Department of Surgery, Pathology and Cancer Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1073/pnas.1018867108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3286905PMC
February 2012

TAK1 inhibition promotes apoptosis in KRAS-dependent colon cancers.

Authors:
Anurag Singh Michael F Sweeney Min Yu Alexa Burger Patricia Greninger Cyril Benes Daniel A Haber Jeff Settleman

Cell 2012 Feb;148(4):639-50

Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1016/j.cell.2011.12.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291475PMC
February 2012

MET amplification identifies a small and aggressive subgroup of esophagogastric adenocarcinoma with evidence of responsiveness to crizotinib.

Authors:
Jochen K Lennerz Eunice L Kwak Allison Ackerman Michael Michael Stephen B Fox Kristin Bergethon Gregory Y Lauwers James G Christensen Keith D Wilner Daniel A Haber Ravi Salgia Yung-Jue Bang Jeffrey W Clark Benjamin J Solomon A John Iafrate

J Clin Oncol 2011 Dec 31;29(36):4803-10. Epub 2011 Oct 31.

Massachusetts General Hospital/Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1200/JCO.2011.35.4928DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3255989PMC
December 2011

The WTX tumor suppressor regulates mesenchymal progenitor cell fate specification.

Authors:
Annie Moisan Miguel N Rivera Sutada Lotinun Sara Akhavanfard Erik J Coffman Edward B Cook Svetlana Stoykova Siddhartha Mukherjee Jesse A Schoonmaker Alexa Burger Woo Jae Kim Henry M Kronenberg Roland Baron Daniel A Haber Nabeel Bardeesy

Dev Cell 2011 May;20(5):583-596

Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1016/j.devcel.2011.03.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052985PMC
May 2011

The evolving war on cancer.

Authors:
Daniel A Haber Nathanael S Gray Jose Baselga

Cell 2011 Apr;145(1):19-24

Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1016/j.cell.2011.03.026DOI Listing
April 2011

Aberrant overexpression of satellite repeats in pancreatic and other epithelial cancers.

Authors:
David T Ting Doron Lipson Suchismita Paul Brian W Brannigan Sara Akhavanfard Erik J Coffman Gianmarco Contino Vikram Deshpande A John Iafrate Stan Letovsky Miguel N Rivera Nabeel Bardeesy Shyamala Maheswaran Daniel A Haber

Science 2011 Feb 13;331(6017):593-6. Epub 2011 Jan 13.

Massachusetts General Hospital Cancer Center and Department of Medicine, Harvard Medical School, Boston, MA 02114, USA.

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http://www.sciencemag.org/cgi/doi/10.1126/science.1200801
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http://dx.doi.org/10.1126/science.1200801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701432PMC
February 2011

Circulating tumor cells: approaches to isolation and characterization.

Authors:
Min Yu Shannon Stott Mehmet Toner Shyamala Maheswaran Daniel A Haber

J Cell Biol 2011 Feb;192(3):373-82

Howard Hughes Medical Institute, Harvard Medical School, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1083/jcb.201010021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101098PMC
February 2011