Cuiying Xiao

Cuiying Xiao

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Cuiying Xiao

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Physiology and effects of nucleosides in mice lacking all four adenosine receptors.

PLoS Biol 2019 03 1;17(3):e3000161. Epub 2019 Mar 1.

Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, United States of America.

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http://dx.doi.org/10.1371/journal.pbio.3000161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415873PMC
March 2019

Brs3 neurons in the mouse dorsomedial hypothalamus regulate body temperature, energy expenditure, and heart rate, but not food intake.

Nat Neurosci 2018 11 22;21(11):1530-1540. Epub 2018 Oct 22.

Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.

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http://www.nature.com/articles/s41593-018-0249-3
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http://dx.doi.org/10.1038/s41593-018-0249-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203600PMC
November 2018

Activation of adenosine A or A receptors causes hypothermia in mice.

Neuropharmacology 2018 09 13;139:268-278. Epub 2018 Mar 13.

Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2018.02.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6067974PMC
September 2018

Melanotan II causes hypothermia in mice by activation of mast cells and stimulation of histamine 1 receptors.

Am J Physiol Endocrinol Metab 2018 09 29;315(3):E357-E366. Epub 2018 May 29.

Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland.

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http://dx.doi.org/10.1152/ajpendo.00024.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171009PMC
September 2018

Bombesin-like receptor 3 (Brs3) expression in glutamatergic, but not GABAergic, neurons is required for regulation of energy metabolism.

Mol Metab 2017 11 15;6(11):1540-1550. Epub 2017 Sep 15.

Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22128778173057
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http://dx.doi.org/10.1016/j.molmet.2017.08.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681273PMC
November 2017

Hypothermia in mouse is caused by adenosine A and A receptor agonists and AMP via three distinct mechanisms.

Neuropharmacology 2017 03 30;114:101-113. Epub 2016 Nov 30.

Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2016.11.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5183552PMC
March 2017

SIRT6 Is Essential for Adipocyte Differentiation by Regulating Mitotic Clonal Expansion.

Cell Rep 2017 03;18(13):3155-3166

Faculty of Health Sciences, University of Macau, Macau SAR, China, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892, USA; Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.03.006DOI Listing
March 2017

Bombesin-Like Receptor 3: Physiology of a Functional Orphan.

Trends Endocrinol Metab 2016 09 4;27(9):603-605. Epub 2016 Apr 4.

Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tem.2016.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992652PMC
September 2016

Search for an Endogenous Bombesin-Like Receptor 3 (BRS-3) Ligand Using Parabiotic Mice.

PLoS One 2015 12;10(11):e0142637. Epub 2015 Nov 12.

Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, 20892, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0142637PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643013PMC
June 2016

Bombesin-like receptor 3 regulates blood pressure and heart rate via a central sympathetic mechanism.

Am J Physiol Heart Circ Physiol 2016 Apr 22;310(7):H891-8. Epub 2016 Jan 22.

Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland;

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http://dx.doi.org/10.1152/ajpheart.00963.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865066PMC
April 2016

Peripheral Adenosine A3 Receptor Activation Causes Regulated Hypothermia in Mice That Is Dependent on Central Histamine H1 Receptors.

J Pharmacol Exp Ther 2016 Feb 25;356(2):474-82. Epub 2015 Nov 25.

Diabetes, Endocrinology, and Obesity Branch (J.L.C., C.X., R.A.P., M.L.R.), Molecular Recognition Section, Laboratory of Bioorganic Chemistry (D.K.T., K.A.J.), and Mouse Metabolism Core (O.G.), National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland; and Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St. Louis, Missouri (Z.C., D.S.)

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http://dx.doi.org/10.1124/jpet.115.229872DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746492PMC
February 2016

Anti-obesity and metabolic efficacy of the β3-adrenergic agonist, CL316243, in mice at thermoneutrality compared to 22°C.

Obesity (Silver Spring) 2015 Jul 5;23(7):1450-9. Epub 2015 Jun 5.

Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, USA.

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http://doi.wiley.com/10.1002/oby.21124
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http://dx.doi.org/10.1002/oby.21124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482793PMC
July 2015

Integration of body temperature into the analysis of energy expenditure in the mouse.

Mol Metab 2015 Jun 10;4(6):461-70. Epub 2015 Mar 10.

Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S22128778150005
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http://dx.doi.org/10.1016/j.molmet.2015.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443293PMC
June 2015

Effect of intermittent cold exposure on brown fat activation, obesity, and energy homeostasis in mice.

PLoS One 2014 17;9(1):e85876. Epub 2014 Jan 17.

Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0085876PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895006PMC
September 2014

Biphasic effect of melanocortin agonists on metabolic rate and body temperature.

Cell Metab 2014 Aug 26;20(2):333-45. Epub 2014 Jun 26.

Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2014.05.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126889PMC
August 2014

Partitioning circadian transcription by SIRT6 leads to segregated control of cellular metabolism.

Cell 2014 Jul;158(3):659-72

Center for Epigenetics and Metabolism, University of California, Irvine, Irvine, CA 92697, USA; Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA; Institute for Genomics and Bioinformatics, University of California, Irvine, Irvine, CA 92697, USA; INSERM U904, Sprague Hall, University of California, Irvine, Irvine, CA 92697, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674140088
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http://dx.doi.org/10.1016/j.cell.2014.06.050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472354PMC
July 2014

Regulation of body temperature and brown adipose tissue thermogenesis by bombesin receptor subtype-3.

Am J Physiol Endocrinol Metab 2014 Mar 22;306(6):E681-7. Epub 2014 Jan 22.

Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland; and.

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http://dx.doi.org/10.1152/ajpendo.00615.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948979PMC
March 2014

Progression of chronic liver inflammation and fibrosis driven by activation of c-JUN signaling in Sirt6 mutant mice.

J Biol Chem 2012 Dec 16;287(50):41903-13. Epub 2012 Oct 16.

Genetics of Development and Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M112.415182
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http://dx.doi.org/10.1074/jbc.M112.415182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516737PMC
December 2012

Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance.

J Clin Invest 2011 Nov 3;121(11):4477-90. Epub 2011 Oct 3.

Genetics of Development and Disease Branch, NIH, 10/9N105, 10 Center Drive, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1172/JCI46243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204833PMC
November 2011

Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity.

Proc Natl Acad Sci U S A 2010 Dec 22;107(50):21790-4. Epub 2010 Nov 22.

Department of Genetics, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.1016306107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003110PMC
December 2010

BRCA1 affects global DNA methylation through regulation of DNMT1.

Cell Res 2010 Nov 7;20(11):1201-15. Epub 2010 Sep 7.

Genetics of Development and Disease Branch, 10/9N105, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1038/cr.2010.128DOI Listing
November 2010

SIRT6 deficiency results in severe hypoglycemia by enhancing both basal and insulin-stimulated glucose uptake in mice.

J Biol Chem 2010 Nov 16;285(47):36776-84. Epub 2010 Sep 16.

Genetics of Development and Diseases Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M110.168039
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http://dx.doi.org/10.1074/jbc.M110.168039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2978606PMC
November 2010

Hepatic-specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis.

Cell Metab 2010 Sep;12(3):224-36

Genetics of Development and Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.cmet.2010.06.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2935915PMC
September 2010

Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice.

Cancer Cell 2008 Oct;14(4):312-23

Genetics of Development and Disease Branch, 10/9N105, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.ccr.2008.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2643030PMC
October 2008

Interplay among BRCA1, SIRT1, and Survivin during BRCA1-associated tumorigenesis.

Mol Cell 2008 Oct;32(1):11-20

Genetics of Development and Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S109727650800656
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http://dx.doi.org/10.1016/j.molcel.2008.09.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2577018PMC
October 2008

Adiponectin gene variation -4522C/T is associated with type 2 diabetic obesity and insulin resistance in Chinese.

J Genet Genomics 2007 Oct;34(10):877-84

Department of Medical Genetics, West China Hospital, Sichuan University, and Division of Human Morbid Genomics, State Key Laboratory of Biotherapy of Human Diseases, Chengdu 610041, China.

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http://linkinghub.elsevier.com/retrieve/pii/S167385270760099
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http://dx.doi.org/10.1016/S1673-8527(07)60099-XDOI Listing
October 2007

PKHD1 gene silencing may cause cell abnormal proliferation through modulation of intracellular calcium in autosomal recessive polycystic kidney disease.

J Biochem Mol Biol 2007 Jul;40(4):467-74

Department of Medical Genetics, West China Hospital, Sichuan University, Guoxue Xiang No. 37, Chengdu 610041, PR China.

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http://dx.doi.org/10.5483/bmbrep.2007.40.4.467DOI Listing
July 2007

The XIST noncoding RNA functions independently of BRCA1 in X inactivation.

Cell 2007 Mar;128(5):977-89

Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, 10/9N105, National Institutes of Health, Bethesda, MD 20892, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S009286740700179
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http://dx.doi.org/10.1016/j.cell.2007.01.034DOI Listing
March 2007

Mutation screening of the FKBP6 gene and its association study with spermatogenic impairment in idiopathic infertile men.

Reproduction 2007 Feb;133(2):511-6

Divison of Human Morbid Genomics, State Key Laboratory of Biotherapy, Department of Medical Genetics, West China Hospital, Sichuan University, Renmin Nanlu, Section 3 #17, Chengdu 610041, People's Republic of China.

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http://dx.doi.org/10.1530/REP-06-0125DOI Listing
February 2007

Absence of the full-length breast cancer-associated gene-1 leads to increased expression of insulin-like growth factor signaling axis members.

Cancer Res 2006 Jul;66(14):7151-7

Genetics of Development and Disease Branch and Diabetes Branch, National Institute of Diabetes, Digestive and Kidney Diseases, NIH, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-4570DOI Listing
July 2006

ATM-Chk2-p53 activation prevents tumorigenesis at an expense of organ homeostasis upon Brca1 deficiency.

EMBO J 2006 May 4;25(10):2167-77. Epub 2006 May 4.

Genetics of Development and Diseases Branch, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://emboj.embopress.org/cgi/doi/10.1038/sj.emboj.7601115
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http://dx.doi.org/10.1038/sj.emboj.7601115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1462967PMC
May 2006

Preliminary study of the relationship between DAZ gene copy deletions and spermatogenic impairment in Chinese men.

Fertil Steril 2006 Apr;85(4):1061-3

Department of Medical Genetics, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.

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http://dx.doi.org/10.1016/j.fertnstert.2005.09.025DOI Listing
April 2006

A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression.

Cell Metab 2005 Dec;2(6):399-409

Genetics of Development and Disease Branch, 10/9N105, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1016/j.cmet.2005.10.010DOI Listing
December 2005

Distinct transcriptional regulation and function of the human BACE2 and BACE1 genes.

FASEB J 2005 May;19(7):739-49

Department of Psychiatry, Brain Research Center, The University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1096/fj.04-3426comDOI Listing
May 2005

Association between DNA variant sites in the apolipoprotein A5 gene and coronary heart disease in Chinese.

Metabolism 2005 May;54(5):568-72

State Key Laboratory of Biotherapy, Division of Human Morbid Genomics, Department of Medical Genetics, West China Hospital, Sichuan University, Chengdu 610041, China.

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http://dx.doi.org/10.1016/j.metabol.2004.11.009DOI Listing
May 2005

[Idiopathic male infertility and partial copy deletion of DAZ gene family].

Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2004 Oct;21(5):444-7

Department of Medical Genetics, West China Hospital, Sichuan University, Chengdu,Sichuan, 610041 P.R.China.

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October 2004

Novel P143L polymorphism of the LCAT gene is associated with dyslipidemia in Chinese patients who have coronary atherosclerotic heart disease.

Biochem Biophys Res Commun 2004 May;318(1):4-10

Department of Medical Genetics, West China Hospital, Sichuan University, Chengdu 610041, China.

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http://dx.doi.org/10.1016/j.bbrc.2004.03.177DOI Listing
May 2004

Runx3 and Runx1 are required for CD8 T cell development during thymopoiesis.

Proc Natl Acad Sci U S A 2003 Jun 9;100(13):7731-6. Epub 2003 Jun 9.

Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot 76100, Israel.

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http://dx.doi.org/10.1073/pnas.1232420100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC164656PMC
June 2003

Molecular cloning and characterization of a mouse spermatogenesis-related ring finger gene znf230.

Biochem Biophys Res Commun 2003 Jun;306(2):347-53

Department of Medical Genetics, West China Hospital, Sichuan University, Renminnanlu No. 17, Section 3, 610041, Chengdu, PR China.

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http://dx.doi.org/10.1016/s0006-291x(03)00970-7DOI Listing
June 2003

A single nucleotide deletion of 293delT in SEDL gene causing spondyloepiphyseal dysplasia tarda in a four-generation Chinese family.

Mutat Res 2003 Apr;525(1-2):61-5

Department of Medical Genetics, West China Hospital, Sichuan University and Key Laboratory of Morbid Genomics and Forensic Medicine of Sichuan Province, Chengdu 610041, PR China.

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http://dx.doi.org/10.1016/s0027-5107(02)00315-9DOI Listing
April 2003

Clustering of variations and haplotype analysis in the highly variable region of exon 11 of BRCA1 in Chinese women with sporadic breast cancer.

Hum Mutat 2002 Nov;20(5):404-5

Department of Medical Genetics, West China Hospital, Sichuan University, China.

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http://dx.doi.org/10.1002/humu.9071DOI Listing
November 2002

Relationship between a novel polymorphism of lipoprotein lipase gene and coronary heart disease.

Chin Med J (Engl) 2002 May;115(5):677-80

Department of Medical Genetics, West China Hospital, West China Medical Center, Sichuan University, Chengdu 610041, China.

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May 2002

Novel mutations of PKD1 gene in Chinese patients with autosomal dominant polycystic kidney disease.

Nephrol Dial Transplant 2002 Jan;17(1):75-80

Department of Medical Genetics, West China Medical Center, Sichuan University, Sichuan Province, Chengdu 610041, People's Republic of China.

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http://dx.doi.org/10.1093/ndt/17.1.75DOI Listing
January 2002