Publications by authors named "Chuanwei Wang"

18 Publications

  • Page 1 of 1

Deployment of a bioabsorbable plate as the rigid buttress for skull base repair after endoscopic pituitary surgery.

Gland Surg 2021 Mar;10(3):1010-1017

Department of Neurosurgery, Qilu Hospital of Shandong University, Jinan, China.

Background: Bioresorbable alloplastic implants have become desirable as a rigid buttress for reconstructing skull base defects. This study aimed to describe the use of a biodegradable plate (PolyMax RAPID) in skull base repair of endoscopic endonasal pituitary surgery and to investigate the clinical outcome and safety of this novel method.

Methods: Between January 2019 and January 2020, 22 patients with pituitary adenomas who underwent endoscopic skull base repair with a Polymax RAPID plate were included. After endonasal transsphenoidal surgery, a trimmed bioresorbable plate was placed in the position between the dura and the bone of the skull base to reconstruct the sellar floor and buttress the pituitary gland and sellar packing. The patient demographics, radiologic imaging, and postoperative outcomes were carefully reviewed. All patients were followed up by a routine nasal endoscopic assessment and radiologic examinations.

Results: The present study comprised 10 (45.5%) males and 12 (54.4%) females with an average age of 51.9 years. There were 7 (31.8%) growth hormone (GH) secreting adenomas, 2 (9.1%) thyroid stimulating hormone (TSH) secreting adenomas, and 13 (59.1%) non-functioning adenomas. Enlarged sellar floor and paranasal sinusitis were seen in 13 (59.1%) and 11 (50.0%) cases shown by preoperative computed tomography (CT) or magnetic resonance imaging (MRI), respectively. There were 6 (27.3%) grade-1 and 16 (72.7%) grade-0 cases by intraoperative cerebrospinal fluid (CSF) leak grading. None of these patients received lumbar drains postoperatively and no postoperative CSF rhinorrhea was detected in our series. The PolyMax RAPID plates which could be clearly identified on postoperative CT or sagittal T1-weighted MRI were shown to provide an ideal rigid buttress for sellar repair.

Conclusions: The Polymax RAPID plate can be an optimal implant to achieve rigid repair of sellar floor defects after endonasal transsphenoidal pituitary surgery.
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http://dx.doi.org/10.21037/gs-20-642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8033064PMC
March 2021

Glioblastoma Therapy Using Codelivery of Cisplatin and Glutathione Peroxidase Targeting siRNA from Iron Oxide Nanoparticles.

ACS Appl Mater Interfaces 2020 Sep 17;12(39):43408-43421. Epub 2020 Sep 17.

Department of Neurosurgery, Qilu Hospital and Institute of Brain and Brain-Inspired Science, Cheeloo College of Medicine, Shandong University, 107 Wenhua Xi Road, Jinan, Shandong 250012, P. R. China.

Glioblastoma (GBM) is the most common and lethal type of malignant brain tumor in adults. Currently, interventions are lacking, the median overall survival of patients with GBM is less than 15 months, and the postoperative recurrence rate is greater than 60%. We proposed an innovative local chemotherapy involving the construction of gene therapy-based iron oxide nanoparticles (IONPs) as a treatment for patients with glioblastoma after surgery that targeted ferroptosis and apoptosis to address these problems. The porous structure of IONPs with attached carboxyl groups was modified for the codelivery of small interfering RNA (siRNA) targeting glutathione peroxidase 4 (si-GPX4) and cisplatin (Pt) with high drug loading efficiencies. The synthesized folate (FA)/Pt-si-GPX4@IONPs exerted substantial effects on glioblastoma in U87MG and P3#GBM cells, but limited effects on normal human astrocytes (NHAs). During intracellular degradation, IONPs significantly increased iron (Fe and Fe) levels, while Pt destroyed nuclear DNA and mitochondrial DNA, leading to apoptosis. Furthermore, IONPs increased HO levels by activating reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX). The Fenton reaction between Fe, Fe, and intracellular HO generated potent reactive oxygen species (ROS) to initiate ferroptosis, while the co-released si-GPX4 inhibited GPX4 expression and synergistically improved the therapeutic efficacy through a mechanism related to ferroptosis. As a result, superior therapeutic effects with low systemic toxicity were achieved both and , indicating that our nanoformulations might represent safe and efficient ferroptosis and apoptosis inducers for use in combinatorial glioblastoma therapy.
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http://dx.doi.org/10.1021/acsami.0c12042DOI Listing
September 2020

Data on the evolution of curing characteristics and properties during the room-temperature annealing process in SSBR/BR gums and SSBR/BR/SiO composites.

Data Brief 2019 Dec 16;27:104660. Epub 2019 Oct 16.

Shandong Provincial Key Laboratory of Olefin Catalysis and Polymerization, Key Laboratory of Rubber-Plastics, Ministry of Education/Shandong Provincial Key Laboratory of Rubber-Plastics, School of Polymer Science and Engineering, Qingdao University of Science and Technology, Qingdao 266042, China.

The present article contains the data of tensile stress-strain curves, crosslinking characteristics curves, filler dispersion images and dynamic mechanical properties of SSBR/BR blends and SSBR/BR/SiO composites during room-temperature annealing. The data in this article aims to accurately describe the evolution of the network structures and physical mechanical properties of rubber composites during annealing process. Tensile stress-strain curves of un-vulcanized rubber gums and compounds were obtained by an electrical tensile tester with a speed of 100 mm/min. The crosslinking characteristics of the un-vulcanized rubber blends or composites after different annealing time were measured by a rotor-free vulcameter at 150 °C. The macroscopic filler dispersion of the filled vulcanizates was analyzed on a smooth cross-section of cut rubber. The dynamic mechanical properties of vulcanized SSBR/BR blends and SSBR/BR/SiO composites were investigated by a dynamic mechanical thermal analyser with different temperature ranges and strains. These findings may serve as references for the scientific processing of green tire materials in automotive industry, and this article is related to our research article entitled "Effect of room-temperature annealing on structures and properties of SSBR/BR blends and SSBR/BR/SiO composites" (Xinping Zhang et al., 2019).
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http://dx.doi.org/10.1016/j.dib.2019.104660DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6833471PMC
December 2019

Anterior Cerebral Artery Rupture During Extended Endoscopic Endonasal Transsphenoidal Approach for Severely Calcified Craniopharyngioma.

World Neurosurg 2019 Jun 4;126:537-540. Epub 2019 Mar 4.

Department of Neurosurgery, Qilu Hospital of Shandong University and Institute of Brain and Brain-Inspired Science, Shandong University, Jinan, Shandong Province, China; Shandong Key Laboratory of Brain Function Remodeling, Jinan, Shandong Province, China. Electronic address:

Background: This report discusses the risks and complications of using the extended endoscopic endonasal transsphenoidal approach (EEETA) in a special craniopharyngioma case to caution neurosurgeons.

Case Description: A 38-year-old woman with craniopharyngioma underwent EEETA surgery. Her anterior cerebral artery was punctured intraoperatively and clipped using an aneurysm clip through the nose in an emergency procedure.

Conclusions: The coexistence of severe calcified craniopharyngiomas, especially with sharp calcified spurs, a narrow distance between the anterior communicating artery and the planum sphenoidale, and a narrow distance between the bilateral internal carotid arteries is a significant warning signal during EEETA for craniopharyngiomas. In this circumstance, it may be preferable to use open microsurgical approaches. If the anterior communicating artery or anterior cerebral artery is punctured during EEETA, another method is available to fix the problem using an aneurysm clip through the nose, and not only endovascular embolization.
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http://dx.doi.org/10.1016/j.wneu.2019.02.128DOI Listing
June 2019

The diagnostic value and functional roles of phosphoglycerate mutase 1 in glioma.

Oncol Rep 2016 Oct 25;36(4):2236-44. Epub 2016 Aug 25.

Department of Neurosurgery, Qilu Hospital of Shandong University, Brain Science Research Institute of Shandong University, Jinan, Shandong 250012, P.R. China.

Previous studies indicated that phosphoglycerate mutase 1 (PGAM1) is involved in many cancer types and promotes breast cancer progression. However, the role of PGAM1 in glioma remains unclear. The present study aimed to investigate the association of PGAM1 expression with glioma grade and the role of PGAM1 in proliferation, apoptosis, migration and invasion of glioma cells. The mRNA and protein expression of PGAM1 was analysed in glioma tissues and normal brain tissues. The expression of PGAM1 was examined further by immunohistochemical analysis. In addition, we inhibited the expression of PGAM1 in glioma cell line by siRNA to evaluate its role in glioma proliferation, apoptosis, migration and invasion. The mRNA and protein expression of PGAM1 was significantly greater in glioma than normal brain tissues. PGAM1 expression was associated with the WHO grade of glioma. siRNA knockdown of PGAM1 significantly inhibited glioma cell proliferation, promoted glioma cell apoptosis, induced S phase cell cycle arrest and inhibited glioma cell migration and invasion in vitro. PGAM1 may be associated with the grade of glioma and be involved in the biological behavior of glioma cells. PGAM1 might be a novel therapeutic target in glioma.
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http://dx.doi.org/10.3892/or.2016.5046DOI Listing
October 2016

Clinical Features and Surgical Treatment of Aggressive Meningiomas.

Turk Neurosurg 2015 ;25(5):690-4

Qilu Hospital of Shandong University, Brain Science Research Institute of Shandong University, Department of Neurosurgery, Jinan, PR China.

Aim: To explore the clinical features and surgical treatment of aggressive meningiomas (AMs).

Material And Methods: Samples from 55 patients with AMs were analyzed, and their clinical characteristics, molecular biological mechanism, and surgical treatment were studied in combination with the literature.

Results: The main clinical and imaging features of AMs included manifestations of local structures invaded by tumors, frequently irregular or flat tumors in shape, more obvious cerebral edema surrounding the tumors, seldom calcification of tumor, more frequent and typical dural tail sign, often absent white or black ring sign, partial or complete occlusion of venous sinus and hyperplasia and destruction of local skull. Simpson I resection was achieved in 31 cases, II in 13, III-IV in 11. No severe complications and death occurred after operation.

Conclusion: AMs have prominent clinical features. Appropriate surgery can provide a good therapeutic effect.
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http://dx.doi.org/10.5137/1019-5149.JTN.10714-14.1DOI Listing
May 2016

Primary extradural meningiomas in head: a report of 19 cases and review of literature.

Int J Clin Exp Pathol 2015 1;8(5):5624-32. Epub 2015 May 1.

Department of Neurosurgery, Qilu Hospital of Shandong University, Brain Science Research Institute of Shandong University Jinan, Shandong Province, PR China.

Primary extradural meningiomas (PEMs) in head were rare tumors. Here we analyzed 231 cases of PEMs in head (including our 19 cases) reported in the literature during the CT era. We found that PEMs in head accounted for 0.8%-1.8% of all meningiomas. The constituent ratio of male PEMs in head increases markedly. PEMs in head have bimodal distribution of ages. The most common presenting symptom was a mass in the region of the lesion. The average duration of symptom was 2.38 years. The skull convexities, paranasal sinuse and nasal cavity, and middle ear ranked as the top three of all sites of tumors. The most common type was Type II (calvarial or diploic). Among 231 cases, total, subtotal and partial removals of tumors were achieved in 89%, 5.5% and 3.1% respectively, and no death occurred perioperatively in all patients. 90% were benign, 5.6% atypical and 3.9% malignant in the 231 cases. The most common histopathological subtype was meningothelial meningioma. The recurrence and tumor-related death rates were 22.4% and 8.2% respectively during a mean 3.03-year follow-up. Our results demonstrate that PEMs in head have some marked clinical characteristics compared with primary intradural meningiomas. Total tumor removal together with a wide excision of all involved tissues followed by the reconstruction of tissue defects is the best surgical project. The prognoses are good in the benign cases after complete surgical resections.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4503145PMC
April 2016

Clinical features and surgical treatment of asymptomatic meningiomas.

Turk Neurosurg 2015 ;25(1):121-5

Qilu Hospital of Shandong University, Brain Science Research Institute of Shandong University, Department of Neurosurgery, Jinan, PR China.

Aim: To explore clinical features and surgical treatment of asymptomatic meningiomas (AMs).

Material And Methods: Clinical materials of 122 patients with AMs treated surgically were analyzed retrospectively and the associated literatures were reviewed.

Results: There were 39 males and 83 females whose ages ranged from 38 to 72 years with a mean of 58.6 years in this series. The cerebral convexity (32.8%), parasagittal region (31.1%), and parafalcine (29.5%) ranked in the top three of all locations of AMs. The average size of the tumors was 2.8 cm in diameter, with a tumoral calcification rate of 33.6%. Among the 82 cases of AMs monitored with serial computerized tomography (CT) or magnetic resonance imaging (MRI) scannings, 44 had no obvious growth during a period of 3 to 18 months (mean 10.5 months) whereas 38 increased in diameter from 0.2 to 1.8 cm (mean 0.4 cm) every year during a period of 6 to 38 months (mean 26 months). Total resection was achieved in all cases. No death or permanent neurological deficits occurred.

Conclusion: AMs have some marked clinical characteristics compared with the symptomatic meningiomas. Their definitive treatment project rests with patients'age, results of follow-up, surgical risk-effect ratio, size, calcification of the tumor as well as patient preference.
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http://dx.doi.org/10.5137/1019-5149.JTN.11788-14.0DOI Listing
November 2015

Chronic subdural haematoma evolving from traumatic subdural hydroma.

Brain Inj 2015 23;29(4):462-5. Epub 2014 Dec 23.

Department of Neurosurgery, Qilu Hospital of Shandong University , Jinan , PR China .

Objective: This study aimed to investigate the incidence and clinical characteristics of chronic subdural haematoma (CSDH) evolving from traumatic subdual hydroma (TSH).

Methods: The clinical characteristics of 44 patients with CSDH evolving from TSH were analysed retrospectively and the relevant literature was reviewed.

Results: In 22.6% of patients, TSH evolved into CSDH. The time required for this evolution was 14-100 days after injury. All patients were cured with haematoma drainage.

Conclusions: TSH is one possible origin of CSDH. The clinical characteristics of TSH evolving into CSDH include polarization of patient age and chronic small effusion. The injuries usually occur during deceleration and are accompanied by mild cerebral damage.
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http://dx.doi.org/10.3109/02699052.2014.990513DOI Listing
March 2016

A peptide-mediated targeting gene delivery system for malignant glioma cells.

Int J Nanomedicine 2013 24;8:3631-40. Epub 2013 Sep 24.

Department of Neurosurgery, Qilu Hospital of Shandong University, Jinan, People's Republic of China ; Brain Science Research Institute of Shandong University, Jinan, People's Republic of China.

Glioblastoma multiforme (GBM) is the most common and malignant glioma. Although there has been considerable progress in treatment strategies, the prognosis of many patients with GBM remains poor. In this work, polyethylenimine (PEI) and the VTWTPQAWFQWV (VTW) peptide were modified and synthesized into GBM-targeting nanoparticles. The transfection efficiency of U-87 (human glioblastoma) cells was evaluated using fluorescence microscopy and flow cytometry. Cell internalization was investigated to verify the nanoparticle delivery into the cytoplasm. Results showed that the methods of polymer conjugation and the amount of VTW peptide were important factors to polymer synthesis and transfection. The PEI-VTW20 nanoparticles increased the transfection efficiency significantly. This report describes the use of VTW peptide-based PEI nanoparticles for intracellular gene delivery in a GBM cell-specific manner.
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http://dx.doi.org/10.2147/IJN.S44990DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790891PMC
April 2014

Role of colchicine-induced microtubule depolymerization in hyperalgesia via TRPV4 in rats with chronic compression of the dorsal root ganglion.

Neurol Res 2014 Jan 6;36(1):70-8. Epub 2013 Dec 6.

The aim of this study is to investigate the effect of microtubule depolymerization by colchicine on hyperalgesia mediated by transient receptor potential vanilloid 4 (TRPV4) in a neuropathic pain model of chronic compression of the dorsal root ganglion (DRG) (hereafter termed CCD) in rat. Intrathecal administration of microtubule-depolymerizing agent, colchicine, attenuated the activated effect of 4alpha-phorbol 12, 13-didecanoate (4alpha-PDD, TRPV4 specific agonist) on mechanical and thermal hyperalgesia in CCD rats. This observation is in agreement with our in vitro experiments with DRG cells that showed a significant attenuation of 4alpha-PDD-activated Ca(2+)-influx and substance P (SP) release with the colchicine treatment. We conclude that microtubule depolymerization by colchicine can regulate pain sensitivity by depressing the hyperalgesia mediated by TRPV4.
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http://dx.doi.org/10.1179/1743132813Y.0000000261DOI Listing
January 2014

Clinical characteristics and treatment of angiomatous meningiomas: a report of 27 cases.

Int J Clin Exp Pathol 2013 15;6(4):695-702. Epub 2013 Mar 15.

Department of Neurosurgery, Qilu Hospital of Shandong University, Brain Science Research Institute of Shandong University, Jinan, Shandong Province, PR China.

Angiomatous meningioma (AM) is a rare histological variant of meningioma. Twenty seven patients (14 male and 13 female) with angiomatous meningioma were treated in our institution. Their clinical presentation, neuroimaging studies, treatment and follow-up were investigated. The age of patients ranged from 24 to 72 years with a mean of 51.8 years. The clinical presentation was non-specific and depended on the location of the tumor and was mainly due to the mass effect. On computed tomography (CT) scanning, AMs showed slightly hyperintensity. On magnetic resonance imaging (MRI), AMs demonstrated hypointensity on T1-weighted images (T1WI), hyperintensity on T2-weighted images (T2WI), slight hypointensity on diffusion-weighted images (DWI), enhancement on postcontrast T1WI, peritumoral edema, and rich signal voids of vessels in the tumor. On histology, all tumors exhibited abundant blood vessels with at least focal classic meningothelial differentiation. Thirteen, eight, and six cases were achieved Simpson grade I, II and III-IV resection respectively. Nineteen cases were followed for 8 to 125 months with a mean of 47.9 months. Four patients with residual tumor were treated with postoperative radiation therapy and all of them had stable disease. One patient with Simpson grade II resection was not treated with radiation therapy and developed recurrent tumor in 5 years. In conclusion, angiomatous meningiomas have relative high male to female ratio, more frequent peritumoral edema, and rich blood vessels. Gross total resection is still the treatment of choice. These patients with residual tumor after surgery can benefit from radiation therapy. Overall, the prognosis of AMs are as good as other benign meningiomas.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3606859PMC
October 2013

Modulation of human visual evoked potentials in 3-dimensional perception after stimuli produced with an integral imaging method.

Clin EEG Neurosci 2012 Oct;43(4):303-11

Department of Ophthalmology and Visual Science, Yokohama City University, Graduate School of Medical Sciences, Fukuura, Kanazawa-ku, Yokohama, Japan.

We investigated the neurophysiological correlates of stereoscopic 3-dimensional (3-D) depth perception by studying human visual evoked potentials (VEPs) with an integral imaging method characterized by horizontal but not vertical disparity. The VEPs were recorded in 10 healthy men under 4 conditions. In condition I, stimuli A (flat, 2-dimensional [2-D] image) and B (concave 3-D image) were presented at random. In condition II, stimuli A and C (convex 3-D image) were presented at random. In condition III, stimuli B and C were presented at random. In condition IV, stimuli A, B, and C were presented at random. The data for flat VEPs to stimulus A were combined in conditions I and II. The data for concave VEPs to stimulus B were combined in conditions I and III. The data for convex VEPs to stimulus C were combined in conditions II and III. When 2-way analysis of variance (ANOVA) for 2 factors, stimulus conditions (flat VEPs, concave VEPs, and convex VEPs) and electrode positions, was applied for VEP data, the N1 and N2 peak amplitudes differed significantly among the 3 stimulus conditions. In condition IV, the N1 peak amplitudes differed significantly among the 3 stimuli. Multiple comparisons followed by Bonferroni adjustment did not detect differences in the N1 peak amplitude between stimuli A and B, between stimuli A and C, or between stimuli B and C. We concluded that VEPs to concave or convex 3-D stimuli were significantly different from VEPs to flat 2-D stimuli. This is the first report showing modulation of human VEPs in 3-D perception with an integral imaging method.
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http://dx.doi.org/10.1177/1550059412445608DOI Listing
October 2012

Functional interaction of TRPV4 channel protein with annexin A2 in DRG.

Neurol Res 2012 Sep 2;34(7):685-93. Epub 2012 Jul 2.

Department of Physical Medicine and Rehabilitation, Qilu Hospital, Shandong University, Jinan, China.

Background: Transient receptor potential vanilloid 4 (TRPV4) is a Ca(2+)-permeable, non-selective cation channel that is involved in the transmission of pain signals mediated by dorsal root ganglion (DRG). Annexin A2 belongs to a class of membrane-binding proteins that plays an important role in the regulation of ion channels. Nevertheless, little is known about the interaction between them in DRG. In this paper, we evaluated the functional interaction of TRPV4 with annexin A2 in DRG.

Methods: We have used immunocytochemistry and co-immunoprecipitation assays to investigate the interaction between annexin A2 and TRPV4 in DRG. The role of annexin A2 in the regulation of TRPV4 activity in DRG was further verified by measurement of intracellular free calcium concentrations ([Ca(2+)](i)) and substance P (SP) release.

Results: First, annexin A2 was showed partial co-localization with TRPV4 in DRG neurons. Then, annexin A2 and TRPV4 were co-precipitated with each other in DRG lysates. Furthermore, the downregulation of annexin A2 using specific small interfering RNA significantly inhibited Ca(2+) influx and SP mediated by TRPV4.

Conclusion: Our results provide evidence that annexin A2 is associated with TRPV4 and regulates TRPV4-mediated Ca(2+) influx and SP release in DRG neurons. The objective of this work is to determine the influence of annexin A2 on TRPV4 in DRG neurons, which may be the basis for treatment of pain relief.
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http://dx.doi.org/10.1179/1743132812Y.0000000065DOI Listing
September 2012

Biodegradable microfibers deliver the antitumor drug temozolomide to glioma C6 cells in vitro.

Pharmazie 2010 Nov;65(11):830-4

Department of Neurosurgery, QiLu Hospital, Shandong University, Jinan, PR China.

To develop effective implants for delivery of 3,4-dihydro-3-methyl-4-oxoimidazo[5,1-d]-as-tetrazine-8-carboxamide (temozolomide; TM) with low initial burst and less neurotoxicity, TM-loaded poly-propylene carbonate (PPC) fiber was fabricated by electrospinning. Some of the fiber sheets were then covered with alginate (ALG). Influences of several preparation parameters on drug delivery behavior were investigated. The micro-morphology of these fibers was studied using scanning electron microscopy and differential scanning calorimetry. In vitro release properties of two forms of samples were observed and their cytotoxicity against C6 glioma cells was assessed. Using strict preparation parameters, smooth and uniform fiber could only be obtained when the PPC concentration was 8 % by weight, at 20cm and a voltage of 15 kV between the nozzle and the collection instrument. Fiber diameter was about 3 microm. The initial burst of drug-fiber sheets was reduced after the fiber sheets were covered with ALG. Cytotoxicity test results suggested that both forms of drug fibers inhibit the C6 glioma cells continuously; the pure drug-fiber sheets were strongly cytotoxic. We conclude that (a) electrospinning is a reliable fabrication method for M-loaded PPC fibers; and (b) an ALG coating reduces the initial burst of the fiber sheets.
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November 2010

Clinical characteristics and treatment of ectopic meningiomas.

J Neurooncol 2011 Mar 6;102(1):81-7. Epub 2010 Jul 6.

Department of Neurosurgery, Qilu Hospital of Shandong University, Jinan 250012, People's Republic of China.

We have examined the clinical characteristics and treatment of ectopic meningiomas (EMs). Samples from 17 patients with EMs were analyzed, and their clinical characteristics, mechanism, and treatment were studied in combination with the literature. The main clinical manifestations of EMs included increased intracranial pressure, epilepsy, local mass, and local occupying effects, but diagnosis of EMs depended on the pathology. Surgical removal can achieve the double objectives of confirmed diagnosis and treatment of tumors. The clinical characteristics of EMs vary with the sites of tumors. Operation is the treatment of first choice. Prognosis is better than that of typical meningiomas.
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http://dx.doi.org/10.1007/s11060-010-0288-4DOI Listing
March 2011

P1 and P2 components of human visual evoked potentials are modulated by depth perception of 3-dimensional images.

Clin Neurophysiol 2010 Mar 13;121(3):386-91. Epub 2010 Jan 13.

Department of Ophthalmology, Yokohama City University, Graduate School of Medical Sciences, Kanazawa-ku, Yokohama, Japan.

Objective: To determine the cerebral activity correlated with depth perception of 3-dimensional (3D) images, by recording of human visual evoked potentials (VEPs).

Methods: Two figures consisting of smaller and larger squares were presented alternately. VEPs were recorded in two conditions. In condition I, we used two figures which yielded flat 2-dimensional images. In condition II, we used two figures which yielded 3D images, which were concave and convex, respectively.

Results: P1, P2, and N1/P2 amplitude were significantly greater in condition II than in condition I. The P1/N1 amplitude tended to be greater in condition II than in condition I. P1 and N1 were predominantly distributed over the right temporo-parieto-occipital regions. P2 and N2 were distributed over bilateral parieto-occipital regions.

Conclusions: The difference in P1 amplitude between two conditions can be explained by the difference between conditions, one of which yielded depth perception while the other did not, since previous studies showed that P1 and N1 are modulated by perception of images in depth. The role of P2 and the mechanism responsible for the increase in P2 amplitude during condition II remain unknown.

Significance: We recorded VEPs and identified electrophysiological correlates of depth perception with 3D images produced by concave/convex figures.
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http://dx.doi.org/10.1016/j.clinph.2009.12.005DOI Listing
March 2010

The effect of attended color on the P1/N1 component of visual event-related potentials.

Neurosci Lett 2007 Dec 11;429(1):22-7. Epub 2007 Oct 11.

Department of Ophthalmology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Yokohama 236-0004, Japan.

Ten subjects were asked to pay attention to green or to red, when each visual stimulus was presented as two small squares, one green and the other red. They were instructed to push a button with the right hand, when the attended color was on the right side, and to push a button with the left hand, when the attended color was on the left side. The P1/N1 peak-to-peak amplitudes of visual event-related potentials were significantly higher when subjects focused attention on green rather than on red. We assume that the attended color had the effect of modulating the P1/N1 components.
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http://dx.doi.org/10.1016/j.neulet.2007.09.075DOI Listing
December 2007