Christoph Maack

Christoph Maack

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Christoph Maack

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CaMKII does not control mitochondrial Ca uptake in cardiac myocytes.

J Physiol 2019 Feb 16. Epub 2019 Feb 16.

Comprehensive Heart Failure Center (CHFC), University Clinic Würzburg, Würzburg, Germany.

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http://dx.doi.org/10.1113/JP276766DOI Listing
February 2019

Myocardial infarction is sufficient to increase GLP-1 secretion, leading to improved left ventricular contractility and mitochondrial respiratory capacity.

Diabetes Obes Metab 2018 12 16;20(12):2911-2918. Epub 2018 Aug 16.

Department of Internal Medicine I, University Hospital Aachen, RWTH Aachen University, Aachen, Germany.

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http://dx.doi.org/10.1111/dom.13472DOI Listing
December 2018

Rebalancing protein phosphorylation in heart failure to prevent arrhythmias.

Eur J Heart Fail 2018 12 17;20(12):1686-1689. Epub 2018 Oct 17.

Comprehensive Heart Failure Center (CHFC), University Clinic Würzburg, Würzburg, Germany.

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http://dx.doi.org/10.1002/ejhf.1315DOI Listing
December 2018

Reply to 'Metabolic remodelling in heart failure revisited'.

Nat Rev Cardiol 2018 Dec;15(12):780-781

Comprehensive Heart Failure Center (CHFC), University Clinic Würzburg, Würzburg, Germany.

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http://dx.doi.org/10.1038/s41569-018-0116-7DOI Listing
December 2018

Mitochondrial transplantation in humans: "magical" cure or cause for concern?

J Clin Invest 2018 Dec 29;128(12):5191-5194. Epub 2018 Oct 29.

Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1172/JCI124944DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264628PMC
December 2018

Hungry Hearts.

Circ Heart Fail 2018 Dec;11(12):e005642

Comprehensive Heart Failure Center (CHFC), University Clinic Würzburg, Germany.

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https://www.ahajournals.org/doi/10.1161/CIRCHEARTFAILURE.118
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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.118.005642DOI Listing
December 2018

Let's face the fats: palmitate restores cellular redox state in the diabetic heart.

J Physiol 2018 Dec 22. Epub 2018 Dec 22.

Comprehensive Heart Failure Center (CHFC), University Clinic Würzburg, Würzburg, Germany.

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http://dx.doi.org/10.1113/JP277473DOI Listing
December 2018

Scientists on the Spot: Christoph Maack on how to measure mitochondrial parameters in cardiomyocytes.

Cardiovasc Res 2018 Sep;114(11):e84-e86

Department of Translational Research, Comprehensive Heart Failure Center (CHFC), University Clinic Würzburg, Am Schwarzenberg 15, Haus A15, Würzburg, Germany.

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http://dx.doi.org/10.1093/cvr/cvy196DOI Listing
September 2018

Metabolic remodelling in heart failure.

Nat Rev Cardiol 2018 Aug;15(8):457-470

Comprehensive Heart Failure Center (CHFC), University Clinic Würzburg, Würzburg, Germany.

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http://dx.doi.org/10.1038/s41569-018-0044-6DOI Listing
August 2018

Linking Heart Failure to Cancer.

Circulation 2018 Aug;138(7):735-742

Cardiovascular Disease Unit, Ospedale Policlinico San Martino IRCCS & Laboratory of Cardiovascular Biology, Department of Internal Medicine, University of Genova, Italy (E.B., M.C., P.A.).

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https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.118.0
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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.033603DOI Listing
August 2018

Calcium Signaling and Reactive Oxygen Species in Mitochondria.

Circ Res 2018 May;122(10):1460-1478

From the Comprehensive Heart Failure Center, University Clinic Würzburg, Germany.

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http://dx.doi.org/10.1161/CIRCRESAHA.118.310082DOI Listing
May 2018

The Comprehensive Heart Failure Centre in Würzburg, Germany.

Eur Heart J 2018 May;39(20):1757-1760

Professor of Medicine and Cardiology, Comprehensive Heart Failure Centre, Building A15, University & University Hospital Würzburg, Am Schwarzenberg 15, 97078 Würzburg, Tel: ++49-931-201-46502, Fax: ++49-931-201-646502, © SebastianZiegaus.

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http://dx.doi.org/10.1093/eurheartj/ehy202DOI Listing
May 2018

Duration of chronic heart failure affects outcomes with preserved effects of heart rate reduction with ivabradine: findings from SHIFT.

Eur J Heart Fail 2018 02 12;20(2):373-381. Epub 2017 Oct 12.

Department of Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

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http://dx.doi.org/10.1002/ejhf.1021DOI Listing
February 2018

Cardiac effects of SGLT2 inhibitors: the sodium hypothesis.

Cardiovasc Res 2018 01;114(1):12-18

Clinic for Internal Medicine III, University of the Saarland, Homburg 66421, Germany.

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http://dx.doi.org/10.1093/cvr/cvx149DOI Listing
January 2018

Mitochondrial Therapies in Heart Failure.

Handb Exp Pharmacol 2017 ;243:491-514

Klinik für Innere Medizin III, Universitätsklinikum des Saarlandes, 66421, Homburg, Germany.

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http://dx.doi.org/10.1007/164_2016_123DOI Listing
October 2017

Inhibition of MicroRNA-146a and Overexpression of Its Target Dihydrolipoyl Succinyltransferase Protect Against Pressure Overload-Induced Cardiac Hypertrophy and Dysfunction.

Circulation 2017 Aug 13;136(8):747-761. Epub 2017 Jun 13.

From Center for Molecular and Vascular Research, Leuven, Belgium (W.H., A.P., S.D., Pa.C., P.P., A.S.W., S.J., S.H.); Center for Heart Failure Research, Department of Cardiology, CARIM School for Cardiovascular Diseases, Maastricht University, The Netherlands (W.H., A.P., S.D., Pa.C., W.V., R.v.L., B.S., M.v.B., S.H.); Cardiovascular Research Center, OLV Hospital, Aalst, Belgium (W.H.); Laboratory of Angiogenesis and Vascular Metabolism, Vesalius Research Center, Department of Oncology, Leuven, Belgium (A.Q., G.E., S.S., S.V., Pe.C.); Laboratory of Angiogenesis and Vascular Metabolism, Vesalius Research Center, Leuven, Belgium (A.Q., G.E., S.S., S.V., Pe.C.); Amsterdam Medical Center, Amsterdam University, The Netherlands (S.A., I.E., Y.P.); Laboratory for Viral Vector Technology and Gene Therapy, Department of Pharmaceutical and Pharmacological Sciences (R.G., C.V.D.H.), Laboratory for Neurobiology and Gene Therapy, Department of Neurosciences (R.G., C.V.D.H.), Leuven Viral Vector Core, Belgium (R.G., C.V.D.H.); and Klinik für Innere Medezin III, Universitätsklinikum des Saarlandes, Homburg, Germany (A.N., C.M.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.024171DOI Listing
August 2017

Targeting Mitochondrial Calcium Handling and Reactive Oxygen Species in Heart Failure.

Curr Heart Fail Rep 2017 08;14(4):338-349

Klinik für Innere Medizin III, Universitätsklinikum des Saarlandes, 66421, Homburg, Germany.

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http://dx.doi.org/10.1007/s11897-017-0347-7DOI Listing
August 2017

Impact of Oxidative Stress on the Heart and Vasculature: Part 2 of a 3-Part Series.

J Am Coll Cardiol 2017 Jul;70(2):212-229

The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, New York. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2017.05.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663297PMC
July 2017

Mitochondrial energetics and calcium coupling in the heart.

J Physiol 2017 06 10;595(12):3753-3763. Epub 2017 Mar 10.

Klinik für Innere Medizin III, Universitätsklinikum des Saarlandes, Homburg/Saar, Germany.

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http://dx.doi.org/10.1113/JP273609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471421PMC
June 2017

Endogenous nitric oxide formation in cardiac myocytes does not control respiration during β-adrenergic stimulation.

J Physiol 2017 06 14;595(12):3781-3798. Epub 2017 May 14.

Klinik für Innere Medizin III, Universitätsklinikum des Saarlandes, 66421, Homburg, Germany.

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http://dx.doi.org/10.1113/JP273750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471411PMC
June 2017

Barth syndrome cardiomyopathy.

Cardiovasc Res 2017 02 2. Epub 2017 Feb 2.

Klinik für Innere Medizin III, Universitätsklinikum des Saarlandes, 66421 Homburg/Saar, Germany.

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http://dx.doi.org/10.1093/cvr/cvx014DOI Listing
February 2017

Metabolic cardiomyopathies - fighting the next epidemic.

Cardiovasc Res 2017 Feb 16. Epub 2017 Feb 16.

National Institute of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1093/cvr/cvx022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852643PMC
February 2017

Vena cava compression syndrome in patients with obesity presenting with edema and thrombosis.

Obesity (Silver Spring) 2016 08 17;24(8):1648-52. Epub 2016 Jun 17.

Klinik für Kardiologie, Angiologie und internistische Intensivmedizin, Universität des Saarlandes und Universitätsklinikum des Saarlandes, Homburg, Germany.

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http://dx.doi.org/10.1002/oby.21506DOI Listing
August 2016

The cardiac re-AKT-ion to chronic volume overload.

Authors:
Christoph Maack

Eur J Heart Fail 2016 04;18(4):372-4

Klinik für Innere Medizin III, Universitätsklinikum des Saarlandes, 66421 Homburg/Saar, Germany.

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http://doi.wiley.com/10.1002/ejhf.523
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http://dx.doi.org/10.1002/ejhf.523DOI Listing
April 2016

Arrhythmia causes lipid accumulation and reduced glucose uptake.

Basic Res Cardiol 2015 28;110(4):40. Epub 2015 May 28.

Klinik für Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitätsklinikum des Saarlandes, 66421, Homburg, Germany,

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http://dx.doi.org/10.1007/s00395-015-0497-2DOI Listing
February 2016

[Cardiopulmonary Comorbidities].

Dtsch Med Wochenschr 2016 Feb 17;141(4):275-82; quiz 283-4. Epub 2016 Feb 17.

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http://dx.doi.org/10.1055/s-0041-108687DOI Listing
February 2016

Orphaned mitochondria in heart failure.

Authors:
Christoph Maack

Cardiovasc Res 2016 Jan 29;109(1):6-8. Epub 2015 Nov 29.

Klinik für Innere Medizin III, Universitätsklinikum des Saarlandes, Homburg 66421, Germany

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http://dx.doi.org/10.1093/cvr/cvv262DOI Listing
January 2016

Influence of Cardiovascular and Noncardiovascular Co-morbidities on Outcomes and Treatment Effect of Heart Rate Reduction With Ivabradine in Stable Heart Failure (from the SHIFT Trial).

Am J Cardiol 2015 Dec 9;116(12):1890-7. Epub 2015 Oct 9.

Maria Cecilia Hospital, Gruppo Villa Maria (GVM) Care and Research, Ettore Sansavini Health Science Foundation, Cotignola, Italy.

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http://dx.doi.org/10.1016/j.amjcard.2015.09.029DOI Listing
December 2015

C-kit(+) resident cardiac stem cells improve left ventricular fibrosis in pressure overload.

Stem Cell Res 2015 Nov 28;15(3):700-711. Epub 2015 Oct 28.

Klinik für Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universität des Saarlandes, Kirrberger Straße, Gebäude 40, 66421 Homburg/Saar, Germany.

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http://dx.doi.org/10.1016/j.scr.2015.10.017DOI Listing
November 2015

Pathophysiological role of oxidative stress in systolic and diastolic heart failure and its therapeutic implications.

Eur Heart J 2015 Oct 4;36(38):2555-64. Epub 2015 Jul 4.

2nd Medical Clinic, Department of Cardiology, Medical Center of the Johannes Gutenberg University, Langenbeckstrasse 1, Mainz 55131, Germany.

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http://dx.doi.org/10.1093/eurheartj/ehv305DOI Listing
October 2015

Pericardial effusion associated with hypothyroidism in an adult female with down syndrome.

Am J Med Genet A 2015 Jul 6;167(7):1674-5. Epub 2015 Apr 6.

Klinik für Innere Medizin III, Universitätsklinikum des Saarlandes, Homburg, Germany.

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http://doi.wiley.com/10.1002/ajmg.a.37032
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http://dx.doi.org/10.1002/ajmg.a.37032DOI Listing
July 2015

Exercise attenuates inflammation and limits scar thinning after myocardial infarction in mice.

Am J Physiol Heart Circ Physiol 2015 Jul 22;309(2):H345-59. Epub 2015 May 22.

Klinik für Innere Medizin III, Universitätsklinikum des Saarlandes, Homburg/Saar, Germany; and.

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http://dx.doi.org/10.1152/ajpheart.00683.2014DOI Listing
July 2015

Cardiac CaM Kinase II genes δ and γ contribute to adverse remodeling but redundantly inhibit calcineurin-induced myocardial hypertrophy.

Circulation 2014 Oct 14;130(15):1262-73. Epub 2014 Aug 14.

From the Research Unit Cardiac Epigenetics, Department of Cardiology, University of Heidelberg, and DZHK (German Centre for Cardiovascular Research), partner site Heidelberg/Mannheim, Germany (M.M.K., L.H.L., S.K., M.-O.H., U.O., J.B.); Department of Cardiology, Saarland University, Homburg, Germany (M.K., J.-C.R., C.M.); Department of Internal Medicine II, University of Regensburg, Germany (K.N., L.S.M.); British Heart Foundation Centre of Research Excellence, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, United Kingdom (M.D.S.); Department of Internal Medicine, University of Southwestern Texas Medical Center, Dallas (J.A.H.); Institute of Pharmacology, University of Duisburg-Essen, Germany (D.D.); Department of Molecular Pathology, German Cancer Research Center, Heidelberg, Germany (H.-J.G.); Department of Cardiology, University of Heidelberg, and DZHK (German Centre for Cardiovascular Research), partner site Heidelberg/Mannheim, Germany (H.A.K.); and the Department of Molecular Biology, University of Southwestern Texas Medical Center, Dallas (E.N.O.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.114.006185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316667PMC
October 2014

Mitochondrial reactive oxygen species production and elimination.

J Mol Cell Cardiol 2014 Aug 20;73:26-33. Epub 2014 Mar 20.

Klinik für Innere Medizin III, Universitätsklinikum des Saarlandes, 66421 Homburg, Saar, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2014.03.011DOI Listing
August 2014

Pharmacological Treatment of Patients with Chronic Systolic Heart Failure.

Eur Cardiol 2014 Jul;9(1):43-48

Klinik für Innere Medizin III, Universitätsklinikum des Saarlandes, Homburg, Germany.

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https://www.ecrjournal.com/articles/pharmacological-treatmen
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http://dx.doi.org/10.15420/ecr.2014.9.1.43DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6159447PMC
July 2014

Effect of renal denervation on neurohumoral activation triggering atrial fibrillation in obstructive sleep apnea.

Hypertension 2013 Oct 19;62(4):767-74. Epub 2013 Aug 19.

Klinik für Innere Medizin III, Universitätsklinikum des Saarlandes, 66421 Homburg, Saar, Germany.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.113.01728DOI Listing
October 2013

Intracellular Na⁺ and cardiac metabolism.

J Mol Cell Cardiol 2013 Aug 28;61:20-7. Epub 2013 May 28.

Klinik für Innere Medizin III, Universitätsklinikum des Saarlandes, Homburg, Germany.

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http://dx.doi.org/10.1016/j.yjmcc.2013.05.010DOI Listing
August 2013

Myocardial energetics in heart failure.

Basic Res Cardiol 2013 Jul 6;108(4):358. Epub 2013 Jun 6.

Klinik für Innere Medizin III, Universitätsklinikum des Saarlandes, 66421, Homburg, Germany.

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http://link.springer.com/10.1007/s00395-013-0358-9
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http://dx.doi.org/10.1007/s00395-013-0358-9DOI Listing
July 2013

Calcium release microdomains and mitochondria.

Cardiovasc Res 2013 May 14;98(2):259-68. Epub 2013 Feb 14.

Klinik für Innere Medizin III, Universitätsklinikum des Saarlandes, Homburg 66421, Germany.

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http://dx.doi.org/10.1093/cvr/cvt032DOI Listing
May 2013

HDAC4 controls histone methylation in response to elevated cardiac load.

J Clin Invest 2013 Mar 22;123(3):1359-70. Epub 2013 Feb 22.

Klinik für Innere Medizin III, Universitätsklinikum des Saarlandes, Homburg, Germany.

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http://dx.doi.org/10.1172/JCI61084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582114PMC
March 2013

SR and mitochondria: calcium cross-talk between kissing cousins.

J Mol Cell Cardiol 2013 Feb 2;55:42-9. Epub 2012 Aug 2.

Center for Pharmacogenomics, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.yjmcc.2012.07.015DOI Listing
February 2013

Heart-rate reduction by If-channel inhibition with ivabradine restores collateral artery growth in hypercholesterolemic atherosclerosis.

Eur Heart J 2012 May 6;33(10):1223-31. Epub 2011 Aug 6.

Klinik für Innere Medizin III (Kardiologie, Angiologie und Internistische Intensivmedizin), Universitätsklinikum des Saarlandes, Kirrberger Straße, Homburg/Saar, Germany.

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http://eurheartj.oxfordjournals.org/content/ehj/33/10/1223.f
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http://eurheartj.oxfordjournals.org/cgi/doi/10.1093/eurheart
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http://dx.doi.org/10.1093/eurheartj/ehr255DOI Listing
May 2012

Dissecting the role of g-protein-coupled receptor kinase 2 for excitation-contraction coupling.

Authors:
Christoph Maack

Circulation 2012 May 10;125(17):2054-6. Epub 2012 Apr 10.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.112.109389DOI Listing
May 2012

Targeting mitochondrial oxidative stress in heart failure throttling the afterburner.

J Am Coll Cardiol 2011 Jun 27;58(1):83-6. Epub 2011 May 27.

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http://dx.doi.org/10.1016/j.jacc.2011.01.032DOI Listing
June 2011

Interplay of defective excitation-contraction coupling, energy starvation, and oxidative stress in heart failure.

Trends Cardiovasc Med 2011 Apr;21(3):69-73

Medizinische Klinik und Poliklinik, Innere Medizin III, Universitätsklinikum des Saarlandes, 66421 Homburg/Saar, Germany.

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http://dx.doi.org/10.1016/j.tcm.2012.03.002DOI Listing
April 2011

Functional effects of β₁-adrenoceptor polymorphisms on the hemodynamic response to dobutamine with and without β-blocker administration.

Clin Res Cardiol 2011 Feb 6;100(2):129-37. Epub 2010 Sep 6.

Klinik für Innere Medizin III (Kardiologie, Angiologie, Internistische Intensivmedizin), Universitätsklinikum des Saarlandes, Kirrberger Strasse, 66421, Homburg/Saar, Germany.

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http://dx.doi.org/10.1007/s00392-010-0221-zDOI Listing
February 2011

Adverse bioenergetic consequences of Na+-Ca2+ exchanger-mediated Ca2+ influx in cardiac myocytes.

Circulation 2010 Nov 15;122(22):2273-80. Epub 2010 Nov 15.

Universitätsklinikum des Saarlandes, Klinik für Innere Medizin III, 66421 Homburg, Germany.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.110.968057DOI Listing
November 2010

Cardiac Rac1 overexpression in mice creates a substrate for atrial arrhythmias characterized by structural remodelling.

Cardiovasc Res 2010 Aug 7;87(3):485-93. Epub 2010 Mar 7.

Klinik für Innere Medizin III (Kardiologie, Angiologie, Internistische Intensivmedizin), Universitätsklinikum des Saarlandes, Kirrberger Strasse, Homburg/Saar D 66421, Germany.

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http://dx.doi.org/10.1093/cvr/cvq079DOI Listing
August 2010

Elevated cytosolic Na+ increases mitochondrial formation of reactive oxygen species in failing cardiac myocytes.

Circulation 2010 Apr 29;121(14):1606-13. Epub 2010 Mar 29.

Universitätsklinikum des Saarlandes, Klinik für Innere Medizin III, 66421 Homburg, Germany.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.109.914911DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946079PMC
April 2010

Endogenous activation of mitochondrial KATP channels protects human failing myocardium from hydroxyl radical-induced stunning.

Circ Res 2009 Oct 3;105(8):811-7. Epub 2009 Sep 3.

Medizinische Klinik und Poliklinik, Innere Medizin III (Kardiologie/Angiologie), Universitätskliniken des Saarlandes, Homburg/Saar, Germany.

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http://dx.doi.org/10.1161/CIRCRESAHA.109.206359DOI Listing
October 2009

Excitation-contraction coupling and mitochondrial energetics.

Basic Res Cardiol 2007 Sep 27;102(5):369-92. Epub 2007 Jul 27.

Klinik für Innere Medizin III, Universitätsklinikum des Saarlandes, 66421, Homburg/Saar, Germany.

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http://link.springer.com/10.1007/s00395-007-0666-z
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http://dx.doi.org/10.1007/s00395-007-0666-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2785083PMC
September 2007

Sequential opening of mitochondrial ion channels as a function of glutathione redox thiol status.

J Biol Chem 2007 Jul 31;282(30):21889-900. Epub 2007 May 31.

Institute of Molecular Cardiobiology, Department of Medicine, The Johns Hopkins University, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1074/jbc.M702841200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2292488PMC
July 2007

Hotline update of clinical trials and registries presented at the German Cardiac Society Meeting 2007: 2L-Registry, Kardio-Pro, EVER, AFFECT, VTACH, ARTS II, OPTAMI, PEPCAD I, PEPCAD II, GERSHWIN, SPICE, FIX-CHF and CREDIT.

Clin Res Cardiol 2007 Jul 11;96(7):457-68. Epub 2007 Jun 11.

Universität zu Köln, Klinik für Innere Medizin III, Joseph-Stelzmann-Str 9, 50924 Köln, Germany.

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http://dx.doi.org/10.1007/s00392-007-0548-2DOI Listing
July 2007

The role of Na dysregulation in cardiac disease and how it impacts electrophysiology.

Drug Discov Today Dis Models 2007 ;4(4):207-217

The Johns Hopkins University, Institute of Molecular Cardiobiology, Division of Cardiology, Baltimore, MD, USA.

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http://dx.doi.org/10.1016/j.ddmod.2007.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2440714PMC
January 2007

Elevated cytosolic Na+ decreases mitochondrial Ca2+ uptake during excitation-contraction coupling and impairs energetic adaptation in cardiac myocytes.

Circ Res 2006 Jul 15;99(2):172-82. Epub 2006 Jun 15.

Johns Hopkins University, Institute of Molecular Cardiobiology, Division of Cardiology, 720 Rutland Ave, 1059 Ross Bldg, Baltimore, MD 21205-2195, USA.

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http://dx.doi.org/10.1161/01.RES.0000232546.92777.05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2711867PMC
July 2006

Reverse engineering the L-type Ca2+ channel alpha1c subunit in adult cardiac myocytes using novel adenoviral vectors.

Biochem Biophys Res Commun 2005 Apr;329(2):749-54

Institute of Molecular Cardiobiology, Department of Medicine, The Johns Hopkins University, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1016/j.bbrc.2005.02.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2751644PMC
April 2005

Cardiac sodium-calcium exchanger is regulated by allosteric calcium and exchanger inhibitory peptide at distinct sites.

Circ Res 2005 Jan 18;96(1):91-9. Epub 2004 Nov 18.

Johns Hopkins University, Institute of Molecular Cardiobiology, Division of Cardiology, Baltimore, Md 21205-2195, USA.

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http://dx.doi.org/10.1161/01.RES.0000151334.48676.68DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2679901PMC
January 2005

Partial inhibition of sodium/calcium exchange restores cellular calcium handling in canine heart failure.

Circ Res 2004 Aug 24;95(3):292-9. Epub 2004 Jun 24.

Johns Hopkins University Institute of Molecular Cardiobiology, Department of Medicine, Baltimore, Md 21205-2195, USA.

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http://circres.ahajournals.org/content/95/3/292.full.pdf
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http://circres.ahajournals.org/cgi/doi/10.1161/01.RES.000013
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http://dx.doi.org/10.1161/01.RES.0000136817.28691.2dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2703731PMC
August 2004

Carvedilol but not metoprolol reduces beta-adrenergic responsiveness after complete elimination from plasma in vivo.

Circulation 2004 Jun 7;109(25):3182-90. Epub 2004 Jun 7.

Klinik für Innere Medizin III, Universitätsklinikum des Saarlandes, Homburg/Saar, Germany.

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http://dx.doi.org/10.1161/01.CIR.0000130849.08704.24DOI Listing
June 2004

Beta-blocker treatment of chronic heart failure: comparison of carvedilol and metoprolol.

Congest Heart Fail 2003 Sep-Oct;9(5):263-70

Division of Cardiology, The Johns Hopkins University, Baltimore, MD 21205-2195, USA.

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January 2004

Oxygen free radical release in human failing myocardium is associated with increased activity of rac1-GTPase and represents a target for statin treatment.

Circulation 2003 Sep 8;108(13):1567-74. Epub 2003 Sep 8.

Klinik und Poliklinik für Innere Medizin III, Universität des Saarlandes, Homburg/Saar, Germany.

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http://dx.doi.org/10.1161/01.CIR.0000091084.46500.BBDOI Listing
September 2003

Partial agonist activity of bucindolol is dependent on the activation state of the human beta1-adrenergic receptor.

Circulation 2003 Jul 7;108(3):348-53. Epub 2003 Jul 7.

Klinik und Poliklinik für Innere Medizin III, Universität des Saarlandes, Homburg/Saar, Germany.

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http://dx.doi.org/10.1161/01.CIR.0000080325.94345.8BDOI Listing
July 2003

Effects of sildenafil (viagra) on human myocardial contractility, in vitro arrhythmias, and tension of internal mammaria arteries and saphenous veins.

J Cardiovasc Pharmacol 2003 May;41(5):734-43

Medizinische Klinik und Poliklinik, Innere Medizin III, Chirurgische Klinik und Poliklinik, Abteilung Thorax-und Herz-, Homburg, Germany,

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May 2003

Catecholamine release in human heart by bupropion.

Eur J Pharmacol 2003 Apr;467(1-3):169-71

Medizinische Klinik und Poliklinik, Innere Medizin III, Universitätskliniken des Saarlandes, 66421 Homburg, Germany.

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April 2003

Modulation of myocardial contractility by lysophosphatidic acid (LPA).

J Mol Cell Cardiol 2003 Jan;35(1):71-80

Medizinische Klinik und Poliklinik, Innere Medizin III,Universitätskliniken des Saarlandes, 66421, Homburg, Germany.

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January 2003