Publications by authors named "Christian Haass"

100Publications

Emerging Microglia Biology Defines Novel Therapeutic Approaches for Alzheimer's Disease.

Neuron 2020 Dec 22;108(5):801-821. Epub 2020 Oct 22.

German Center for Neurodegenerative Diseases (DZNE) Munich, 81377 Munich, Germany; Chair of Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-Universität München, 81377 Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany. Electronic address:

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December 2020

Loss of TMEM106B potentiates lysosomal and FTLD-like pathology in progranulin-deficient mice.

EMBO Rep 2020 Oct 14;21(10):e50241. Epub 2020 Sep 14.

Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.

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October 2020

γ-Secretase cleavage of the Alzheimer risk factor TREM2 is determined by its intrinsic structural dynamics.

EMBO J 2020 Oct 24;39(20):e104247. Epub 2020 Aug 24.

Bavarian NMR Center at the Department of Chemistry and Institute for Advanced Study, Technical University of Munich, Garching, Germany.

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October 2020

Longitudinal correlation between neurofilament light chain and UMSARS in Multiple System Atrophy.

Clin Neurol Neurosurg 2020 Aug 16;195:105924. Epub 2020 May 16.

Department of Neurology, Ludwig-Maximilians-Universität, Munich, Germany; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. Electronic address:

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August 2020

Editorial overview: Neurobiology of disease.

Curr Opin Neurobiol 2020 04;61:iii-iv

German Center for Neurodegenerative Diseases (DZNE) - Munich & Biomedical Center (BMC), Ludwig-Maximilians-Universität München, 81377 Munich, Germany. Electronic address:

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April 2020

Identification of a rare presenilin 1 single amino acid deletion mutation (F175del) with unusual amyloid-β processing effects.

Neurobiol Aging 2019 12 20;84:241.e5-241.e11. Epub 2019 Sep 20.

Department of Neurology, Ludwig-Maximilians-Universität München, Munich, Germany; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. Electronic address:

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December 2019

[Quo vadis Alzheimer?]

Nervenarzt 2019 Sep;90(9):881-883

Biomedizinisches Centrum (BMC), Biochemie, Ludwig-Maximilians-Universität München & Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) e. V., Feodor-Lynen Str. 17, 81377, München, Deutschland.

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September 2019

[Did Alzheimer research fail entirely? : Failure of amyloid-based clinical studies].

Nervenarzt 2019 Sep;90(9):884-890

Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) München, München, Deutschland.

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September 2019

Aβ oligomers trigger and accelerate Aβ seeding.

Brain Pathol 2020 01 5;30(1):36-45. Epub 2019 Jun 5.

Department of Neurology, Medical Center - University of Freiburg, Freiburg, Germany.

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January 2020

CSF glial biomarkers YKL40 and sTREM2 are associated with longitudinal volume and diffusivity changes in cognitively unimpaired individuals.

Neuroimage Clin 2019 1;23:101801. Epub 2019 Apr 1.

Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain; Alzheimer's Disease and Other Cognitive Disorders Unit, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, Spain; Neurology Department, Hospital Clínic i Provincial de Barcelona, Barcelona, Spain; Universitat Pompeu Fabra, Spain; CIBER Fragilidad y Envejecimiento Saludable (CIBERFES), Madrid, Spain. Electronic address:

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April 2020

Secreted APP Modulates Synaptic Activity: A Novel Target for Therapeutic Intervention?

Neuron 2019 02;101(4):557-559

Chair of Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-University Munich, 81377 Munich, Germany.

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February 2019

Early lysosomal maturation deficits in microglia triggers enhanced lysosomal activity in other brain cells of progranulin knockout mice.

Mol Neurodegener 2018 09 4;13(1):48. Epub 2018 Sep 4.

Chair of Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-Universität München, 81377, Munich, Germany.

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September 2018

Diffusible, highly bioactive oligomers represent a critical minority of soluble Aβ in Alzheimer's disease brain.

Acta Neuropathol 2018 07 23;136(1):19-40. Epub 2018 Apr 23.

Laboratory for Neurodegenerative Research, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Building for Transformative Medicine, 60 Fenwood Road, Boston, MA, 02115, USA.

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July 2018

The ε4 genotype modulates CSF YKL-40 levels and their structural brain correlates in the continuum of Alzheimer's disease but not those of sTREM2.

Alzheimers Dement (Amst) 2017 22;6:50-59. Epub 2016 Dec 22.

Barcelonaβeta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain; Alzheimer's Disease and Other Cognitive Disorders Unit, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.

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December 2016

Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibition Impairs Synaptic Plasticity via Seizure Protein 6.

Biol Psychiatry 2018 03 26;83(5):428-437. Epub 2016 Dec 26.

German Center for Neurodegenerative Diseases, Munich, Germany; Center for Neuropathology and Prion Research, Munich, Germany; Munich Cluster for Systems Neurology, Munich, Germany. Electronic address:

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March 2018

Young microglia restore amyloid plaque clearance of aged microglia.

EMBO J 2017 03 21;36(5):583-603. Epub 2016 Dec 21.

German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany

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March 2017

Frontotemporal dementia: from molecular mechanisms to therapy.

J Neurochem 2016 08;138 Suppl 1:3-5

Department for Neuropathology, University Hospital of Tübingen, Tübingen, Germany.

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August 2016

Reduced hnRNPA3 increases C9orf72 repeat RNA levels and dipeptide-repeat protein deposition.

EMBO Rep 2016 09 26;17(9):1314-25. Epub 2016 Jul 26.

Biomedical Center (BMC), Ludwig-Maximilians-University Munich, Munich, Germany German Center for Neurodegenerative Diseases (DZNE), Munich, Germany Munich Cluster for System Neurology (SyNergy), Munich, Germany

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September 2016

Cerebrospinal fluid sTREM2 levels are associated with gray matter volume increases and reduced diffusivity in early Alzheimer's disease.

Alzheimers Dement 2016 12 14;12(12):1259-1272. Epub 2016 Jul 14.

Barcelonaβeta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain; Alzheimer's Disease and Other Cognitive Disorders Unit, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain. Electronic address:

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December 2016

TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance.

EMBO Mol Med 2016 09 1;8(9):992-1004. Epub 2016 Sep 1.

Biomedical Center (BMC), Biochemistry, Ludwig-Maximilians-University Munich, Munich, Germany Munich Cluster for Systems Neurology (SyNergy), Munich, Germany German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany

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September 2016

Impaired protein degradation in FTLD and related disorders.

Ageing Res Rev 2016 12 7;32:122-139. Epub 2016 May 7.

Biomedical Center (BMC), Biochemistry, Ludwig-Maximilians-University, Munich, Germany. Electronic address:

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December 2016

Generation and deposition of Aβ43 by the virtually inactive presenilin-1 L435F mutant contradicts the presenilin loss-of-function hypothesis of Alzheimer's disease.

EMBO Mol Med 2016 05 2;8(5):458-65. Epub 2016 May 2.

Biomedical Center, Metabolic Biochemistry, Ludwig-Maximilians-University Munich, Munich, Germany DZNE - German Center for Neurodegenerative Diseases, Munich, Germany

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May 2016

Specific Inhibition of β-Secretase Processing of the Alzheimer Disease Amyloid Precursor Protein.

Cell Rep 2016 Mar 25;14(9):2127-2141. Epub 2016 Feb 25.

Systems and Cell Biology of Neurodegeneration, Institute of Regenerative Medicine, University of Zurich, Wagistrasse 12, 8952 Schlieren, Switzerland; Graduate Program in Neuroscience, Neuroscience Center Zurich, 8057 Zurich, Switzerland; Graduate Program of the Zurich Center for Integrative Human Physiology, University of Zurich, 8057 Zurich, Switzerland. Electronic address:

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March 2016

Small-Animal PET Imaging of Tau Pathology with 18F-THK5117 in 2 Transgenic Mouse Models.

J Nucl Med 2016 05 11;57(5):792-8. Epub 2016 Feb 11.

Department of Nuclear Medicine, Ludwig-Maximilians-University of Munich, Munich, Germany Munich Cluster for Systems Neurology (SyNergy), Munich, Germany

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May 2016

Glial Activation and Glucose Metabolism in a Transgenic Amyloid Mouse Model: A Triple-Tracer PET Study.

J Nucl Med 2016 06 18;57(6):954-60. Epub 2016 Feb 18.

Department of Nuclear Medicine, Ludwig-Maximilians-University of Munich, Munich, Germany SyNergy, Ludwig-Maximilians-University of Munich, Munich, Germany; and

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June 2016

Reduced secretion and altered proteolytic processing caused by missense mutations in progranulin.

Neurobiol Aging 2016 Mar 29;39:220.e17-26. Epub 2015 Dec 29.

Biochemistry, Biomedical Center (BMC), Ludwig-Maximilians University, Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany; German Center for Neurodegenerative Diseases, DZNE, Munich, Germany.

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March 2016

Proteolytic Processing of Neuregulin 1 Type III by Three Intramembrane-cleaving Proteases.

J Biol Chem 2016 Jan 16;291(1):318-33. Epub 2015 Nov 16.

From the Biomedical Center, Biochemistry, Ludwig-Maximilians-University Munich, 81377 Munich, the German Center for Neurodegenerative Diseases (DZNE), Munich, 81377 Munich, the Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, and

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January 2016

An amyloid-like cascade hypothesis for C9orf72 ALS/FTD.

Curr Opin Neurobiol 2016 Feb 8;36:99-106. Epub 2015 Nov 8.

German Center for Neurodegenerative Diseases (DZNE), Munich, Feodor-Lynen-Str. 17, 81377 Munich, Germany; Munich Cluster of Systems Neurology (SyNergy), Feodor-Lynen-Str. 17, 81377 Munich, Germany; Biomedical Center (BMC), Ludwig-Maximilians University Munich, Feodor-Lynen-Str. 17, 81377 Munich, Germany.

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February 2016

Inhibition of amyloid-β plaque formation by α-synuclein.

Nat Med 2015 Jul 22;21(7):802-7. Epub 2015 Jun 22.

1] Adolf Butenandt Institute, Department of Biochemistry, Ludwig-Maximilians University, Munich, Germany. [2] Neurocenter, Department of Neurology, University of Freiburg, Freiburg, Germany.

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July 2015

Secretome analysis identifies novel signal Peptide peptidase-like 3 (Sppl3) substrates and reveals a role of Sppl3 in multiple Golgi glycosylation pathways.

Mol Cell Proteomics 2015 Jun 31;14(6):1584-98. Epub 2015 Mar 31.

From the DZNE - German Center for Neurodegenerative Diseases, Munich, Germany; Institute for Metabolic Biochemistry, Ludwig-Maximilians University Munich, Munich, Germany;

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June 2015

Granulin knock out zebrafish lack frontotemporal lobar degeneration and neuronal ceroid lipofuscinosis pathology.

PLoS One 2015 18;10(3):e0118956. Epub 2015 Mar 18.

Adolf-Butenandt-Institute-Biochemistry, Ludwig-Maximilians University Munich, Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.

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February 2016

Nuclear import factor transportin and arginine methyltransferase 1 modify FUS neurotoxicity in Drosophila.

Neurobiol Dis 2015 Feb 8;74:76-88. Epub 2014 Nov 8.

German Center for Neurodegenerative Diseases (DZNE) Tübingen, Germany; Hertie Institute for Clinical Brain Research, Laboratory of Functional Neurogenetics, Tübingen, Germany. Electronic address:

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February 2015

Shedding of glycan-modifying enzymes by signal peptide peptidase-like 3 (SPPL3) regulates cellular N-glycosylation.

EMBO J 2014 Dec 29;33(24):2890-905. Epub 2014 Oct 29.

Adolf Butenandt Institute for Biochemistry, Ludwig-Maximilians University Munich, Munich, Germany DZNE - German Center for Neurodegenerative Diseases, Munich, Germany

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December 2014

Progranulin transcripts with short and long 5' untranslated regions (UTRs) are differentially expressed via posttranscriptional and translational repression.

J Biol Chem 2014 Sep 23;289(37):25879-89. Epub 2014 Jul 23.

From the Adolf-Butenandt Institute, Biochemistry, Ludwig-Maximilians University Munich, 80336 Munich, Germany, the German Center for Neurodegenerative Diseases (DZNE), 80336 Munich, Germany, and the Munich Cluster for Systems Neurology (SyNergy), 80336 Munich, Germany

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September 2014

Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects.

J Neurochem 2014 Jul 19;130(1):4-28. Epub 2014 Apr 19.

Department of Cell and Molecular Biology, Feinberg University School of Medicine, Northwestern University, Chicago, Illinois, USA.

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July 2014

Efficient CRISPR/Cas9 genome editing with low off-target effects in zebrafish.

Development 2013 Dec 20;140(24):4982-7. Epub 2013 Nov 20.

German Center for Neurodegenerative Diseases (DZNE), Schillerstrasse 44, 80336 Munich, Germany.

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December 2013

Genomic editing opens new avenues for zebrafish as a model for neurodegeneration.

J Neurochem 2013 Nov 21;127(4):461-70. Epub 2013 Oct 21.

German Center for Neurodegenerative Diseases (DZNE), Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.

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November 2013

Dipeptide repeat protein pathology in C9ORF72 mutation cases: clinico-pathological correlations.

Acta Neuropathol 2013 Dec 6;126(6):859-79. Epub 2013 Oct 6.

Department of Pathology, Vancouver General Hospital, University of British Columbia, Vancouver, Canada.

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December 2013

Highly efficient targeted mutagenesis in mice using TALENs.

Genetics 2013 Nov 26;195(3):703-13. Epub 2013 Aug 26.

Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Munich, Germany.

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November 2013

Clustering of plaques contributes to plaque growth in a mouse model of Alzheimer's disease.

Acta Neuropathol 2013 Aug 18;126(2):179-88. Epub 2013 Jun 18.

Adolf Butenandt Institute, Biochemistry, Ludwig-Maximilians-University, Munich, Germany.

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August 2013

Stress granules in neurodegeneration--lessons learnt from TAR DNA binding protein of 43 kDa and fused in sarcoma.

FEBS J 2013 Sep 9;280(18):4348-70. Epub 2013 May 9.

Adolf Butenandt Institute, Department of Biochemistry, Ludwig Maximilians University, Munich, Germany.

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September 2013