Chris Pepper

Chris Pepper

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Chris Pepper

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Effects of Systematic Shortening of Noncovalent C8 Side Chain on the Cytotoxicity and NF-κB Inhibitory Capacity of Pyrrolobenzodiazepines (PBDs).

J Med Chem 2019 Feb 13. Epub 2019 Feb 13.

Institute of Pharmaceutical Science, School of Cancer and Pharmaceutical Sciences , King's College London , London SE1 9NH , U.K.

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http://dx.doi.org/10.1021/acs.jmedchem.8b01849DOI Listing
February 2019

Telomere length predicts for outcome to FCR chemotherapy in CLL.

Leukemia 2019 Jan 30. Epub 2019 Jan 30.

Division of Cancer & Genetics, Cardiff University, School of Medicine, Heath Park, Cardiff, UK.

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http://www.nature.com/articles/s41375-019-0389-9
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http://dx.doi.org/10.1038/s41375-019-0389-9DOI Listing
January 2019

PARP inhibition prevents escape from a telomere-driven crisis and inhibits cell immortalisation.

Oncotarget 2018 Dec 25;9(101):37549-37563. Epub 2018 Dec 25.

Division of Cancer and Genetics, School of Medicine, Cardiff University, Heath Park, Cardiff, UK.

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http://dx.doi.org/10.18632/oncotarget.26499DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331021PMC
December 2018

Telomere length is a critical determinant for survival in multiple myeloma.

Br J Haematol 2017 07 24;178(1):94-98. Epub 2017 Mar 24.

Division of Cancer & Genetics, School of Medicine, Cardiff University, Cardiff, UK.

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http://dx.doi.org/10.1111/bjh.14643DOI Listing
July 2017

Telomere length is an independent prognostic marker in MDS but not in de novo AML.

Br J Haematol 2017 07 9;178(2):240-249. Epub 2017 May 9.

Division of Cancer and Genetics, School of Medicine, Cardiff University, Cardiff, UK.

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http://dx.doi.org/10.1111/bjh.14666DOI Listing
July 2017

Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia.

Nat Commun 2017 02 6;8:14175. Epub 2017 Feb 6.

Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.

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http://dx.doi.org/10.1038/ncomms14175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5303820PMC
February 2017

Key Molecular Drivers of Chronic Lymphocytic Leukemia.

Clin Lymphoma Myeloma Leuk 2016 11 10;16(11):593-606. Epub 2016 Aug 10.

Institute of Cancer and Genetics, School of Medicine, Cardiff University, Cardiff, United Kingdom.

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http://dx.doi.org/10.1016/j.clml.2016.08.008DOI Listing
November 2016

Phenotype and immune function of lymph node and peripheral blood CLL cells are linked to transendothelial migration.

Blood 2016 07 1;128(4):563-73. Epub 2016 Jun 1.

Department of Haemato-Oncology, Division of Cancer Studies, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom;

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http://dx.doi.org/10.1182/blood-2016-01-683128DOI Listing
July 2016

Electrocardiogram interpretation and arrhythmia management: a primary and secondary care survey.

Br J Gen Pract 2016 May 29;66(646):e291-6. Epub 2016 Mar 29.

Leeds General Infirmary; and Leeds Institute for Quality Healthcare, Leeds.

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http://dx.doi.org/10.3399/bjgp16X684781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838440PMC
May 2016

Understanding cancer cell survival is key to patient survival.

Lancet Oncol 2015 Feb;16(2):122-4

Cardiff CLL Research Group, School of Medicine, Heath Park, Cardiff, CF14 4XN, UK.

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http://dx.doi.org/10.1016/S1470-2045(15)70003-3DOI Listing
February 2015

Telomere analysis to predict chronic lymphocytic leukemia outcome: a STELA test to change clinical practice?

Expert Rev Hematol 2014 Dec 11;7(6):701-3. Epub 2014 Oct 11.

Institute of Cancer and Genetics, School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK.

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http://dx.doi.org/10.1586/17474086.2014.969705DOI Listing
December 2014

CD8 T-cell recognition of a synthetic epitope formed by t-butyl modification.

Immunology 2014 Oct 5. Epub 2014 Oct 5.

Institute of Cancer and Genetics, Cardiff University, School of Medicine, Cancer and Genetics Building, Heath Park, Cardiff, U.K.

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http://dx.doi.org/10.1111/imm.12398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4557686PMC
October 2014

Targeting RNA transcription and translation in ovarian cancer cells with pharmacological inhibitor CDKI-73.

Oncotarget 2014 Sep;5(17):7691-704

Centre for Drug Discovery and Development, Sansom Institute for Health Research and School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, South Australia, Australia. School of Pharmacy and Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham, United Kingdom.

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http://www.oncotarget.com/fulltext/2296
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202154PMC
http://dx.doi.org/10.18632/oncotarget.2296DOI Listing
September 2014

Development and characterization of a physiologically relevant model of lymphocyte migration in chronic lymphocytic leukemia.

Blood 2014 Jun 17;123(23):3607-17. Epub 2014 Mar 17.

Cardiff Chronic Lymphocytic Leukemia Research Group, Institute of Cancer & Genetics, School of Medicine, Cardiff University, Heath Park, Cardiff, United Kingdom;

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http://dx.doi.org/10.1182/blood-2013-12-544569DOI Listing
June 2014

An unusual defibrillator lead complication identified at explant.

Int J Cardiol 2014 Jun 13;174(2):e66-7. Epub 2014 Apr 13.

Leeds General Infirmary, Great George Street, Leeds, United Kingdom.

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http://dx.doi.org/10.1016/j.ijcard.2014.04.077DOI Listing
June 2014

CD49d is the strongest flow cytometry-based predictor of overall survival in chronic lymphocytic leukemia.

J Clin Oncol 2014 Mar 10;32(9):897-904. Epub 2014 Feb 10.

Pietro Bulian, Antonella Zucchetto, and Valter Gattei, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Centro di Riferimento Oncologico, Aviano; Lilla Cro and Luca Baldini, Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico and Università degli Studi, Milan; Gianluca Gaidano and Davide Rossi, Amedeo Avogadro University of Eastern Piedmont, Novara; Giovanni Del Poeta, Tor Vergata University, S. Eugenio Hospital, Rome, Italy; Tait D. Shanafelt, Mayo Research Center, Rochester, NY; Chris Fegan and Chris Pepper, Institute of Cancer and Genetics, Cardiff University School of Medicine, Cardiff, United Kingdom; Holger Nückel, University of Duisburg-Essen, Essen, Germany; and Antonina V. Kurtova, Alessandra Ferrajoli, and Jan A. Burger, University of Texas MD Anderson Cancer Center, Houston, TX.

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http://dx.doi.org/10.1200/JCO.2013.50.8515DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876311PMC
March 2014

Apoptosis deregulation in CLL.

Adv Exp Med Biol 2013 ;792:151-71

CLL Research Group, Institute of Cancer and Genetics, Cardiff University, Heath Park, Cardiff, Wales, CF14 4XN, UK,

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http://link.springer.com/10.1007/978-1-4614-8051-8_7
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http://dx.doi.org/10.1007/978-1-4614-8051-8_7DOI Listing
February 2014

A novel Cdk9 inhibitor preferentially targets tumor cells and synergizes with fludarabine.

Oncotarget 2014 Jan;5(2):375-85

Cardiff CLL Research Group, Institute of Cancer and Genetics, School of Medicine, Cardiff University, Heath Park, Cardiff, UK.

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http://www.oncotarget.com/fulltext/1568
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964214PMC
http://dx.doi.org/10.18632/oncotarget.1568DOI Listing
January 2014

Dabigatran for the prevention of stroke and systemic embolism in atrial fibrillation: A NICE single technology appraisal.

Pharmacoeconomics 2013 Jul;31(7):551-62

Centre for Health Economics, Alcuin 'A' Block, University of York, Heslington, York, YO10 5DD, UK.

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http://dx.doi.org/10.1007/s40273-013-0051-8DOI Listing
July 2013

The HSP90 inhibitor NVP-AUY922-AG inhibits the PI3K and IKK signalling pathways and synergizes with cytarabine in acute myeloid leukaemia cells.

Br J Haematol 2013 Apr 29;161(1):57-67. Epub 2013 Jan 29.

Cardiff Experimental Cancer Medicine Centre, Institute of Cancer and Genetics, Institute of Cancer and Genetics, School of Medicine, Cardiff University, Cardiff, UK.

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http://dx.doi.org/10.1111/bjh.12215DOI Listing
April 2013

GC-targeted C8-linked pyrrolobenzodiazepine-biaryl conjugates with femtomolar in vitro cytotoxicity and in vivo antitumor activity in mouse models.

J Med Chem 2013 Apr 21;56(7):2911-35. Epub 2013 Mar 21.

Department of Pharmacy, Institute of Pharmaceutical Sciences, King's College London, 150 Stamford Street, London SE1 9NH, United Kingdom.

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http://dx.doi.org/10.1021/jm301882aDOI Listing
April 2013

CDKI-71, a novel CDK9 inhibitor, is preferentially cytotoxic to cancer cells compared to flavopiridol.

Int J Cancer 2012 Mar 21;130(5):1216-26. Epub 2011 Jun 21.

School of Pharmacy and Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham, United Kingdom.

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http://dx.doi.org/10.1002/ijc.26127DOI Listing
March 2012

Telomere dysfunction and its role in haematological cancer.

Br J Haematol 2012 Mar 11;156(5):573-87. Epub 2012 Jan 11.

Department of Haematology,School of Medicine, Cardiff University, Cardiff, UK.

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http://dx.doi.org/10.1111/j.1365-2141.2011.09022.xDOI Listing
March 2012

Dronedarone for the treatment of atrial fibrillation: a NICE single technology appraisal.

Pharmacoeconomics 2012 Jan;30(1):35-46

Centre for Health Economics, University of York, York, UK.

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http://dx.doi.org/10.2165/11594280-000000000-00000DOI Listing
January 2012

A novel tumor antigen derived from enhanced degradation of bax protein in human cancers.

Cancer Res 2011 Aug 22;71(16):5435-44. Epub 2011 Jun 22.

Departments of Infection, Immunity and Biochemistry, School of Medicine, Cardiff University, Cardiff, Wales, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-11-0393DOI Listing
August 2011

CLL: a supplementary question?

Blood 2011 Feb;117(5):1439-40

Cardiff University.

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http://dx.doi.org/10.1182/blood-2010-11-318451DOI Listing
February 2011

A practical, single-view alternative to Stenver's for plain radiographic unilateral and bilateral post-cochlear implant position check.

Cochlear Implants Int 2011 Feb;12(1):53-6

Department of Otolaryngology, St George's Hospital, London, UK.

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http://dx.doi.org/10.1179/146701010X486408DOI Listing
February 2011

Shortened telomeres: a driving force behind leukemia?

Future Oncol 2010 Nov;6(11):1681-6

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http://dx.doi.org/10.2217/fon.10.135DOI Listing
November 2010

Telomere dysfunction and fusion during the progression of chronic lymphocytic leukemia: evidence for a telomere crisis.

Blood 2010 Sep 10;116(11):1899-907. Epub 2010 Jun 10.

Department of Pathology, School of Medicine, Cardiff University, Heath Park, Cardiff, United Kingdom.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2010-02-27
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http://dx.doi.org/10.1182/blood-2010-02-272104DOI Listing
September 2010

The role of Bcl-2 family proteins in chronic lymphocytic leukaemia.

Leuk Res 2010 Jul 31;34(7):837-42. Epub 2010 Mar 31.

Department of Haematological Medicine, King's College London, London, UK.

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http://dx.doi.org/10.1016/j.leukres.2010.03.011DOI Listing
July 2010

Targeting the "partners in crime".

Authors:
Chris Pepper

Blood 2010 Jul;116(1):3-4

Cardiff University.

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http://dx.doi.org/10.1182/blood-2010-04-278499DOI Listing
July 2010

The NF-kappaB inhibitor LC-1 has single agent activity in multiple myeloma cells and synergizes with bortezomib.

Mol Cancer Ther 2010 Jun 1;9(6):1574-82. Epub 2010 Jun 1.

Department of Haematology, School of Medicine, Cardiff University, Cardiff, United Kingdom.

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http://dx.doi.org/10.1158/1535-7163.MCT-10-0104DOI Listing
June 2010

APRIL showers put a spring in the step of CLL cells.

Authors:
Chris Pepper

Leuk Res 2009 Oct 22;33(10):1306-7. Epub 2009 May 22.

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http://dx.doi.org/10.1016/j.leukres.2009.04.031DOI Listing
October 2009

NF-kappaB as a prognostic marker and therapeutic target in chronic lymphocytic leukemia.

Future Oncol 2009 Sep;5(7):1027-37

School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK.

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http://dx.doi.org/10.2217/fon.09.72DOI Listing
September 2009

T-cells in CLL: victims or villains?

Authors:
Chris J Pepper

Leuk Res 2009 Jun 13;33(6):752. Epub 2008 Dec 13.

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http://dx.doi.org/10.1016/j.leukres.2008.11.003DOI Listing
June 2009

Acute renal failure as the presenting feature of leukaemic infiltration in chronic lymphocytic leukaemia.

Clin Exp Nephrol 2009 Apr 3;13(2):179-181. Epub 2009 Mar 3.

Department of Haematology, University Hospital of Wales, Heath Park, Cardiff, CF14 4XW, UK.

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http://link.springer.com/10.1007/s10157-009-0129-y
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http://dx.doi.org/10.1007/s10157-009-0129-yDOI Listing
April 2009

A mechanistic investigation into how long-term resynchronization therapy confers ongoing cardiac functional benefits and improved exercise capacity.

Am J Cardiol 2009 Mar 15;103(5):701-8. Epub 2009 Jan 15.

Academic Unit of Molecular Cardiovascular Medicine, University of Leeds, Leeds, United Kingdom.

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http://dx.doi.org/10.1016/j.amjcard.2008.10.041DOI Listing
March 2009

Rel a is an independent biomarker of clinical outcome in chronic lymphocytic leukemia.

J Clin Oncol 2009 Feb 5;27(5):763-9. Epub 2009 Jan 5.

Department of Haematology, School of Medicine, Cardiff University, Heath Park, Cardiff, United Kingdom.

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http://dx.doi.org/10.1200/JCO.2008.19.1114DOI Listing
February 2009

IgM multiple myeloma: a diagnostic challenge in a patient with coexisting chronic lymphocytic leukaemia.

Int J Hematol 2008 Nov 11;88(4):424-427. Epub 2008 Oct 11.

Department of Haematology, School of Medicine, Cardiff University, Heath Park, CF14 4XN, Cardiff, UK.

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http://link.springer.com/10.1007/s12185-008-0179-z
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http://dx.doi.org/10.1007/s12185-008-0179-zDOI Listing
November 2008

Suppressing the tumor suppressor in CLL?

Authors:
Chris Pepper

Blood 2008 Nov;112(9):3537-8

Cardiff University.

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http://dx.doi.org/10.1182/blood-2008-08-175042DOI Listing
November 2008

Effects of the aurora kinase inhibitors AZD1152-HQPA and ZM447439 on growth arrest and polyploidy in acute myeloid leukemia cell lines and primary blasts.

Haematologica 2008 May 26;93(5):662-9. Epub 2008 Mar 26.

Dept. of Haematology, School of Medicine, Cardiff University, Heath Park, Cardiff, South Glamorgan, CF14 4XN, Wales, UK.

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http://dx.doi.org/10.3324/haematol.12148DOI Listing
May 2008

Two germ line polymorphisms of the tumour suppressor gene p53 may influence the biology of chronic lymphocytic leukaemia.

Leuk Res 2006 Sep 3;30(9):1113-8. Epub 2006 Feb 3.

Department of Haematology, Heart of England NHS Trust, Bordesley Green East, Birmingham, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S014521260600010
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http://dx.doi.org/10.1016/j.leukres.2005.12.014DOI Listing
September 2006

X-ray dose reduction in fluoroscopically guided electrophysiology procedures.

Pacing Clin Electrophysiol 2006 Mar;29(3):262-71

Academic Unit of Medical Physics, University of Leeds, Leeds, UK.

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http://dx.doi.org/10.1111/j.1540-8159.2006.00332.xDOI Listing
March 2006

Using chorioallantoic membranes for non-lethal assessment of persistent organic pollutant exposure and effect in oviparous wildlife.

Ecotoxicology 2003 Feb-Aug;12(1-4):31-45

The Institute of Environmental and Human Health, Texas Tech University, Lubbock, TX 79416, USA.

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June 2003

Flavopiridol induces apoptosis in B-cell chronic lymphocytic leukaemia cells through a p38 and ERK MAP kinase-dependent mechanism.

Leuk Lymphoma 2003 Feb;44(2):337-42

Department of Haematology, Llandough Hospital, Penlan Road, Penarth, Vale of Glamorgan, CF64 2XX, UK.

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http://www.tandfonline.com/doi/full/10.1080/1042819021000029
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http://dx.doi.org/10.1080/1042819021000029984DOI Listing
February 2003