Chris Pepper

Chris Pepper

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Chris Pepper

Chris Pepper

Publications by authors named "Chris Pepper"

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82Publications

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Telomere length is a critical determinant for survival in multiple myeloma.

Br J Haematol 2017 07 24;178(1):94-98. Epub 2017 Mar 24.

Division of Cancer & Genetics, School of Medicine, Cardiff University, Cardiff, UK.

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July 2017

Tumor cell migration is inhibited by a novel therapeutic strategy antagonizing the alpha-7 receptor.

Oncotarget 2017 Feb;8(7):11414-11424

Neuro-Bio Ltd, Culham Science Centre, Abingdon, OX14 3DB, UK.

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February 2017

Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia.

Nat Commun 2017 02 6;8:14175. Epub 2017 Feb 6.

Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.

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February 2017

Key Molecular Drivers of Chronic Lymphocytic Leukemia.

Clin Lymphoma Myeloma Leuk 2016 11 10;16(11):593-606. Epub 2016 Aug 10.

Institute of Cancer and Genetics, School of Medicine, Cardiff University, Cardiff, United Kingdom.

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November 2016

Electrocardiogram interpretation and arrhythmia management: a primary and secondary care survey.

Br J Gen Pract 2016 May 29;66(646):e291-6. Epub 2016 Mar 29.

Leeds General Infirmary; and Leeds Institute for Quality Healthcare, Leeds.

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May 2016

Understanding cancer cell survival is key to patient survival.

Lancet Oncol 2015 Feb;16(2):122-4

Cardiff CLL Research Group, School of Medicine, Heath Park, Cardiff, CF14 4XN, UK.

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February 2015

Telomere analysis to predict chronic lymphocytic leukemia outcome: a STELA test to change clinical practice?

Expert Rev Hematol 2014 Dec 11;7(6):701-3. Epub 2014 Oct 11.

Institute of Cancer and Genetics, School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK.

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December 2014

CD8 T-cell recognition of a synthetic epitope formed by t-butyl modification.

Immunology 2014 Oct 5. Epub 2014 Oct 5.

Institute of Cancer and Genetics, Cardiff University, School of Medicine, Cancer and Genetics Building, Heath Park, Cardiff, U.K.

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October 2014

Targeting RNA transcription and translation in ovarian cancer cells with pharmacological inhibitor CDKI-73.

Oncotarget 2014 Sep;5(17):7691-704

Centre for Drug Discovery and Development, Sansom Institute for Health Research and School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, South Australia, Australia. School of Pharmacy and Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham, United Kingdom.

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September 2014

Development and characterization of a physiologically relevant model of lymphocyte migration in chronic lymphocytic leukemia.

Blood 2014 Jun 17;123(23):3607-17. Epub 2014 Mar 17.

Cardiff Chronic Lymphocytic Leukemia Research Group, Institute of Cancer & Genetics, School of Medicine, Cardiff University, Heath Park, Cardiff, United Kingdom;

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June 2014

An unusual defibrillator lead complication identified at explant.

Int J Cardiol 2014 Jun 13;174(2):e66-7. Epub 2014 Apr 13.

Leeds General Infirmary, Great George Street, Leeds, United Kingdom.

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June 2014

CD49d is the strongest flow cytometry-based predictor of overall survival in chronic lymphocytic leukemia.

J Clin Oncol 2014 Mar 10;32(9):897-904. Epub 2014 Feb 10.

Pietro Bulian, Antonella Zucchetto, and Valter Gattei, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Centro di Riferimento Oncologico, Aviano; Lilla Cro and Luca Baldini, Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico and Università degli Studi, Milan; Gianluca Gaidano and Davide Rossi, Amedeo Avogadro University of Eastern Piedmont, Novara; Giovanni Del Poeta, Tor Vergata University, S. Eugenio Hospital, Rome, Italy; Tait D. Shanafelt, Mayo Research Center, Rochester, NY; Chris Fegan and Chris Pepper, Institute of Cancer and Genetics, Cardiff University School of Medicine, Cardiff, United Kingdom; Holger Nückel, University of Duisburg-Essen, Essen, Germany; and Antonina V. Kurtova, Alessandra Ferrajoli, and Jan A. Burger, University of Texas MD Anderson Cancer Center, Houston, TX.

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March 2014

Apoptosis deregulation in CLL.

Adv Exp Med Biol 2013 ;792:151-71

CLL Research Group, Institute of Cancer and Genetics, Cardiff University, Heath Park, Cardiff, Wales, CF14 4XN, UK,

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February 2014

A novel Cdk9 inhibitor preferentially targets tumor cells and synergizes with fludarabine.

Oncotarget 2014 Jan;5(2):375-85

Cardiff CLL Research Group, Institute of Cancer and Genetics, School of Medicine, Cardiff University, Heath Park, Cardiff, UK.

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January 2014

Reducing inappropriate ENT referrals.

Br J Gen Pract 2013 Aug;63(613):404-5

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August 2013

Dabigatran for the prevention of stroke and systemic embolism in atrial fibrillation: A NICE single technology appraisal.

Pharmacoeconomics 2013 Jul;31(7):551-62

Centre for Health Economics, Alcuin 'A' Block, University of York, Heslington, York, YO10 5DD, UK.

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July 2013

The HSP90 inhibitor NVP-AUY922-AG inhibits the PI3K and IKK signalling pathways and synergizes with cytarabine in acute myeloid leukaemia cells.

Br J Haematol 2013 Apr 29;161(1):57-67. Epub 2013 Jan 29.

Cardiff Experimental Cancer Medicine Centre, Institute of Cancer and Genetics, Institute of Cancer and Genetics, School of Medicine, Cardiff University, Cardiff, UK.

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April 2013

The Hsp90 inhibitor NVP-AUY922-AG inhibits NF-κB signaling, overcomes microenvironmental cytoprotection and is highly synergistic with fludarabine in primary CLL cells.

Oncotarget 2012 May;3(5):525-34

Department of Haematology, Institute of Cancer and Genetics, Cardiff University, School of Medicine, Heath Park, Cardiff, UK.

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May 2012

CDKI-71, a novel CDK9 inhibitor, is preferentially cytotoxic to cancer cells compared to flavopiridol.

Int J Cancer 2012 Mar 21;130(5):1216-26. Epub 2011 Jun 21.

School of Pharmacy and Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham, United Kingdom.

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March 2012

Telomere dysfunction and its role in haematological cancer.

Br J Haematol 2012 Mar 11;156(5):573-87. Epub 2012 Jan 11.

Department of Haematology,School of Medicine, Cardiff University, Cardiff, UK.

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March 2012

A novel tumor antigen derived from enhanced degradation of bax protein in human cancers.

Cancer Res 2011 Aug 22;71(16):5435-44. Epub 2011 Jun 22.

Departments of Infection, Immunity and Biochemistry, School of Medicine, Cardiff University, Cardiff, Wales, United Kingdom.

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August 2011

Aminopeptidase inhibition by the novel agent CHR-2797 (tosedostat) for the therapy of acute myeloid leukemia.

Leuk Res 2011 May 9;35(5):677-81. Epub 2010 Dec 9.

Department of Haematology, School of Medicine, Cardiff University, Cardiff, UK.

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May 2011

CLL: a supplementary question?

Blood 2011 Feb;117(5):1439-40

Cardiff University.

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February 2011

Shortened telomeres: a driving force behind leukemia?

Future Oncol 2010 Nov;6(11):1681-6

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November 2010

Telomere dysfunction and fusion during the progression of chronic lymphocytic leukemia: evidence for a telomere crisis.

Blood 2010 Sep 10;116(11):1899-907. Epub 2010 Jun 10.

Department of Pathology, School of Medicine, Cardiff University, Heath Park, Cardiff, United Kingdom.

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September 2010

The role of Bcl-2 family proteins in chronic lymphocytic leukaemia.

Leuk Res 2010 Jul 31;34(7):837-42. Epub 2010 Mar 31.

Department of Haematological Medicine, King's College London, London, UK.

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July 2010

Targeting the "partners in crime".

Authors:
Chris Pepper

Blood 2010 Jul;116(1):3-4

Cardiff University.

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July 2010

The NF-kappaB inhibitor LC-1 has single agent activity in multiple myeloma cells and synergizes with bortezomib.

Mol Cancer Ther 2010 Jun 1;9(6):1574-82. Epub 2010 Jun 1.

Department of Haematology, School of Medicine, Cardiff University, Cardiff, United Kingdom.

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June 2010

APRIL showers put a spring in the step of CLL cells.

Authors:
Chris Pepper

Leuk Res 2009 Oct 22;33(10):1306-7. Epub 2009 May 22.

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October 2009

NF-kappaB as a prognostic marker and therapeutic target in chronic lymphocytic leukemia.

Future Oncol 2009 Sep;5(7):1027-37

School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK.

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September 2009

T-cells in CLL: victims or villains?

Authors:
Chris J Pepper

Leuk Res 2009 Jun 13;33(6):752. Epub 2008 Dec 13.

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June 2009

Acute renal failure as the presenting feature of leukaemic infiltration in chronic lymphocytic leukaemia.

Clin Exp Nephrol 2009 Apr 3;13(2):179-181. Epub 2009 Mar 3.

Department of Haematology, University Hospital of Wales, Heath Park, Cardiff, CF14 4XW, UK.

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April 2009

A mechanistic investigation into how long-term resynchronization therapy confers ongoing cardiac functional benefits and improved exercise capacity.

Am J Cardiol 2009 Mar 15;103(5):701-8. Epub 2009 Jan 15.

Academic Unit of Molecular Cardiovascular Medicine, University of Leeds, Leeds, United Kingdom.

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March 2009

Rel a is an independent biomarker of clinical outcome in chronic lymphocytic leukemia.

J Clin Oncol 2009 Feb 5;27(5):763-9. Epub 2009 Jan 5.

Department of Haematology, School of Medicine, Cardiff University, Heath Park, Cardiff, United Kingdom.

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February 2009

IgM multiple myeloma: a diagnostic challenge in a patient with coexisting chronic lymphocytic leukaemia.

Int J Hematol 2008 Nov 11;88(4):424-427. Epub 2008 Oct 11.

Department of Haematology, School of Medicine, Cardiff University, Heath Park, CF14 4XN, Cardiff, UK.

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November 2008

Suppressing the tumor suppressor in CLL?

Authors:
Chris Pepper

Blood 2008 Nov;112(9):3537-8

Cardiff University.

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November 2008

Effects of the aurora kinase inhibitors AZD1152-HQPA and ZM447439 on growth arrest and polyploidy in acute myeloid leukemia cell lines and primary blasts.

Haematologica 2008 May 26;93(5):662-9. Epub 2008 Mar 26.

Dept. of Haematology, School of Medicine, Cardiff University, Heath Park, Cardiff, South Glamorgan, CF14 4XN, Wales, UK.

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May 2008

Two germ line polymorphisms of the tumour suppressor gene p53 may influence the biology of chronic lymphocytic leukaemia.

Leuk Res 2006 Sep 3;30(9):1113-8. Epub 2006 Feb 3.

Department of Haematology, Heart of England NHS Trust, Bordesley Green East, Birmingham, UK.

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September 2006

X-ray dose reduction in fluoroscopically guided electrophysiology procedures.

Pacing Clin Electrophysiol 2006 Mar;29(3):262-71

Academic Unit of Medical Physics, University of Leeds, Leeds, UK.

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March 2006

Using chorioallantoic membranes for non-lethal assessment of persistent organic pollutant exposure and effect in oviparous wildlife.

Ecotoxicology 2003 Feb-Aug;12(1-4):31-45

The Institute of Environmental and Human Health, Texas Tech University, Lubbock, TX 79416, USA.

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June 2003

Flavopiridol induces apoptosis in B-cell chronic lymphocytic leukaemia cells through a p38 and ERK MAP kinase-dependent mechanism.

Leuk Lymphoma 2003 Feb;44(2):337-42

Department of Haematology, Llandough Hospital, Penlan Road, Penarth, Vale of Glamorgan, CF64 2XX, UK.

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February 2003

Antisense oligonucleotides complementary to Bax transcripts reduce the susceptibility of B-cell chronic lymphocytic leukaemia cells to apoptosis in a bcl-2 independent manner.

Leuk Lymphoma 2002 Oct;43(10):2003-9

Department of Haematology, Llandough Hospital, Penlan Road, Penarth, Vale of Glamorgan, CF64 2XX, UK.

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October 2002