Publications by authors named "Chen Wang"

4,292 Publications

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Detailed Investigation of the Contribution of Gas-Phase Air Contaminants to Exposure Risk during Indoor Activities.

Environ Sci Technol 2022 Aug 11. Epub 2022 Aug 11.

Department of Chemistry, Colorado State University, Fort Collins, Colorado 80524, United States.

Analytical capabilities in atmospheric chemistry provide new opportunities to investigate indoor air. HOMEChem was a chemically comprehensive indoor field campaign designed to investigate how common activities, such as cooking and cleaning, impacted indoor air in a test home. We combined gas-phase chemical data of all compounds, excluding those with concentrations <1 ppt, with established databases of health effect thresholds to evaluate potential risks associated with gas-phase air contaminants and indoor activities. The chemical composition of indoor air is distinct from outdoor air, with gaseous compounds present at higher levels and greater diversity─and thus greater predicted hazard quotients─indoors than outdoors. Common household activities like cooking and cleaning induce rapid changes in indoor air composition, raising levels of multiple compounds with high risk quotients. The HOMEChem data highlight how strongly human activities influence the air we breathe in the built environment, increasing the health risk associated with exposure to air contaminants.
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http://dx.doi.org/10.1021/acs.est.2c01381DOI Listing
August 2022

Evaluating the role of biochar in mitigating the inhibition of polyethylene nanoplastics on anaerobic granular sludge.

Water Res 2022 Aug 12;221:118855. Epub 2022 Jul 12.

Centre for Technology in Water and Wastewater, School of Civil and Environmental Engineering, University of Technology Sydney, Sydney, NSW 2007, Australia. Electronic address:

The extensive application of anaerobic granular sludge (AGS) to wastewater treatment for methane recovery has drawn considerable attention to the system performances affected by the presence of emerging contaminants in wastewater such as nanoplastics. However, effective strategies on how to mitigate the inhibition caused by nanoplastics remained unavailable. In this study, a novel strategy using biochar to mitigate the inhibition on the AGS performances caused by polyethylene nanoplastics (PE-NPs) was proposed and the corresponding mitigating mechanisms involved were explored. The PE-NPs solely decreased the level of methane recovery of AGS to 71.3 ± 2.7% of control, which was subsequently increased to 85.6 ± 0.8% of control with the presences of both biochar and PE-NPs, although biochar solely showed no obvious effect on methane production. The addition of biochar also elevated the granule size of AGS, along with AGS integrity based on the morphological observation. Moreover, the distributions of live cells and functional microbes related to acidification and methanation increased with biochar addition compared to sole PE-NPs exposure. More extracellular polymeric substance (EPS) was secreted when biochar was involved in AGS systems, with more protein being detected to maintain the granule structure of AGS. Evaluation of adsorption tests indicated that biochar possessed stronger affinity for PE-NPs than AGS, thus capturing the PE-NPs that would originally contact AGS and posing less toxicity to microorganisms.
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http://dx.doi.org/10.1016/j.watres.2022.118855DOI Listing
August 2022

Vinyl chloride catalytic combustion on Pt/CeO: Tuning Pt chemical state to promote Cl removing.

Chemosphere 2022 Aug 7:135861. Epub 2022 Aug 7.

Key Laboratory for Advanced Materials and Research Institute of Industrial Catalysis, School of Chemistry & Molecular Engineering, East China University of Science and Technology, Shanghai 200237, China.

Supported Pt catalysts usually produce chlorinated byproducts during chlorinated volatile organic compounds (CVOCs) combustion, the removal of formed surface chlorine species is the key to improve the activity, selectivity and stability. In this paper, the Pt chemical state is adjusted by the interaction between Pt and CeO through controlling the morphology of CeO, which further affects the catalytic performance of VC combustion. For Pt/CeO-octahedron, the weak interaction between Pt and CeO results in the formation of PtO, facilities VC adsorption and C-Cl bonds cleavage and becomes a key active site to accommodate the dissociated Cl species. While the strong interaction leads to the formation of PtCeO solid solution on Pt/CeO-rod has relative lower ability in Cl species removal compared with PtO. Density functional theory (DFT) calculations also confirms that the introduced Pt species reduces the concentration of Cl species on the surface as well as the chlorinated-byproducts. Hence, Pt/CeO-octahedron outperformed Pt/CeO-rod and Pt/CeO-cube with 90% VC conversion at 280 °C. Furthermore, under the same VC conversion (90%), the concentration of chlorinated byproducts on Pt/CeO-octahedron was only 4% than that of Pt/CeO-rod.
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http://dx.doi.org/10.1016/j.chemosphere.2022.135861DOI Listing
August 2022

Development of an underwater networking system using bio-inspired electrocommunication.

Bioinspir Biomim 2022 Aug 9. Epub 2022 Aug 9.

College of Engineering, Peking University, Rm.232, Mechanics Buld., No.5 Yiheyuan Rd., Haidian District, Beijing, Beijing, 100871, CHINA.

Current underwater communication typically includes acoustic, optical, radio frequency, and magneto-inductive channels. Wireless sensor networks are usually built on these four channels. However, these underwater networks are vulnerable to complex aquatic environments. In nature, weakly electric fish are able to communicate electrically (called electrocommunication), which is "invisible'' to most other animals, to convey information such as species, courtship, and environmental conditions. Inspired by the electrocommunication of weakly electric fish, an artificial electrocommunication system that uses an electric induction (EI) channel has been developed recently. This paper further develops an underwater networking system using the EI channel, which addresses the solutions to collision avoidance and routing problems during electrocommunication networking. In particular, a CSMA/CA-based electrocommunication mechanism was used to solve the collision problem. Then, a single-hop underwater electrocommunication network (UEN) was established. Furthermore, a complex multi-hop UEN was implemented on the basis of the AODV routing protocol. Theoretical analysis, simulations, and experiments were conducted to demonstrate the effectiveness of the developed UEN. Extensive results show that the UEN holds the potential to serve as a complement to future underwater wireless sensor networks.
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http://dx.doi.org/10.1088/1748-3190/ac8859DOI Listing
August 2022

Humoral responses after inactivated COVID-19 vaccination in individuals with and without prior SARS-CoV-2 infection: A prospective cohort study.

J Med Virol 2022 Aug 8. Epub 2022 Aug 8.

School of Population Medicine and Public Health, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Background: We evaluated and compared humoral immune responses after inactivated COVID-19 vaccination among naïve individuals, asymptomatically infected individuals, and recovered patients with varying severity.

Methods: In this multicenter, prospective cohort study, blood samples from 666 participants were collected before and after two doses of inactivated COVID-19 vaccination.

Results: Among 392 SARS-CoV-2-naïve individuals, the seroconversion rate increased significantly from 51.8% (median anti-spike protein pan-immunoglobulins [S-Igs] titer:0.8 U/mL) after the first dose to 96% (median S-Igs titer:79.5 U/mL) after the second dose. 32% of naïve individuals had detectable neutralizing antibodies (NAbs) against the original strain, but all of them lost neutralizing activity against the Omicron variant. In 274 individuals with natural infection, humoral immunity was significantly improved after a single vaccine dose, with median S-Igs titers of 757.8U/mL, 1247.0U/mL, 1280.0U/mL, and 2367.0U/mL for asymptomatic infections, mild cases, moderate cases, and severe/critical cases, respectively. NAb titers also improved significantly. However, the second dose did not substantially increase antibody levels.

Conclusions: Although a booster dose is needed for those without infection, our findings indicate that recovered patients should receive only a single dose of the vaccine, regardless of the clinical severity, until there is sufficient evidence to confirm the benefits of a second dose. This article is protected by copyright. All rights reserved.
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http://dx.doi.org/10.1002/jmv.28055DOI Listing
August 2022

A novel risk model based on cuproptosis-related lncRNAs predicted prognosis and indicated immune microenvironment landscape of patients with cutaneous melanoma.

Front Genet 2022 22;13:959456. Epub 2022 Jul 22.

Department of Pharmacy, First People's Hospital of Linping District, Hangzhou, ZG, China.

Cutaneous melanoma (CM) is an aggressive form of malignancy with poor prognostic value. Cuproptosis is a novel type of cell death regulatory mechanism in tumors. However, the role of cuproptosis-related long noncoding RNAs (lncRNAs) in CM remains elusive. The cuproptosis-related lncRNAs were identified using the Pearson correlation algorithm. Through the univariate and multivariate Cox regression analysis, the prognosis of seven lncRNAs associated with cuproptosis was established and a new risk model was constructed. ESTIMATE, CIBERSORT, and single sample gene set enrichment analyses (ssGSEA) were applied to evaluate the immune microenvironment landscape. The Kaplan-Meier survival analysis revealed that the overall survival (OS) of CM patients in the high-risk group was remarkably lower than that of the low-risk group. The result of the validated cohort and the training cohort indicated that the risk model could produce an accurate prediction of the prognosis of CM. The nomogram result demonstrated that the risk score based on the seven prognostic cuproptosis-related lncRNAs was an independent prognostic indicator feature that distinguished it from other clinical features. The result of the immune microenvironment landscape indicated that the low-risk group showed better immunity than high-risk group. The immunophenoscore (IPS) and immune checkpoints results conveyed a better benefit potential for immunotherapy clinical application in the low-risk groups. The enrichment analysis and the gene set variation analysis (GSVA) were adopted to reveal the role of cuproptosis-related lncRNAs mediated by the immune-related signaling pathways in the development of CM. Altogether, the construction of the risk model based on cuproptosis-related lncRNAs can accurately predict the prognosis of CM and indicate the immune microenvironment of CM, providing a new perspective for the future clinical treatment of CM.
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http://dx.doi.org/10.3389/fgene.2022.959456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9354044PMC
July 2022

Quantitative proteomic sequencing of hybrid populations reveals the function of sorbitol in apple resistance to .

Hortic Res 2022 17;9:uhac115. Epub 2022 May 17.

State Key Laboratory of Crop Biology, College of Life Sciences, Shandong Agricultural University, Taian, Shandong 271018, China.

Apple ring rot, which is caused by , is one of the most devastating diseases of apple. However, the lack of a known molecular resistance mechanism limits the development of resistance breeding. Here, the 'Golden Delicious' and 'Fuji Nagafu No. 2' apple cultivars were crossed, and a population of 194 individuals was generated. The hybrids were divided into five categories according to their differences in resistance during three consecutive years. Quantitative proteomic sequencing was performed to analyze the molecular mechanism of the apple response to infection. Hierarchical clustering and weighted gene coexpression network analysis revealed that photosynthesis was significantly correlated with the resistance of apple to . The level of chlorophyll fluorescence in apple functional leaves increased progressively as the level of disease resistance improved. However, the content of soluble sugar decreased with the improvement of disease resistance. Further research revealed that sorbitol, the primary photosynthetic product, played major roles in apple resistance to . Increasing the content of sorbitol by overexpressing dramatically enhanced resistance of apple calli to by activating the expression of salicylic acid signaling pathway-related genes. However, decreasing the content of sorbitol by silencing showed the opposite phenotype. Furthermore, exogenous sorbitol treatment partially restored the resistance of -RNAi lines to . Taken together, these findings reveal that sorbitol is an important metabolite that regulates the resistance of apple to and offer new insights into the mechanism of plant resistance to pathogens.
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http://dx.doi.org/10.1093/hr/uhac115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9346975PMC
May 2022

Machine learning and other information analyses for risk in social networks.

Risk Anal 2022 Aug;42(8):1603-1605

Department of Engineering Systems and Environment, University of Virginia, Charlottesville, Virginia, USA.

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http://dx.doi.org/10.1111/risa.13945DOI Listing
August 2022

Rationale and study design for empirical additional lesions for premature ventricular complex from the outflow tract: a multi-center, prospective randomized trial (EASE-PVC study).

J Interv Card Electrophysiol 2022 Aug 6. Epub 2022 Aug 6.

Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Guangzhou Road 300, Nanjing, 210029, China.

Background: Late recurrence after ablation remains a significant issue in patients with premature ventricular complexes (PVCs) who undergo catheter ablation. In this study, we aimed to test the hypothesis that empirical additional ablation (EAA) would improve the long-term control of PVCs from outflow tracts (OT-PVCs) compared with the approach of limited single point ablation at the assumptive location.

Methods: EASE-PVC study (ChiCTR2200055340) is a prospective multi-center, randomized, and controlled trial designed to assess the effectiveness and safety of empirical additional ablation in patients with OT-PVCs. After successful elimination of OT-PVCs, the patients will be randomized into two groups. In patients randomized to the EAA group, additional lesion applications at sites surrounding the successful ablation site will be delivered empirically. For patients randomized to the control group, no additional empiric ablation will be performed around the successful ablation site. The primary endpoint will be freedom from PVC recurrence at 3 months following ablation, without antiarrhythmic drug therapy.

Conclusions: The EASE-PVC study is designed to compare the effectiveness and safety of two different strategies for ablation in patients with OT-PVCs, namely empirical additional ablation strategy versus conventional single point ablation strategy. This prospective, multi-center, and randomized controlled trial, with comparative data evaluating procedural and long-term follow-up results, aims to elucidate the superiority of empirical additional ablation for the long-term control of OT-PVCs compared with the traditional single point ablation strategy.

Clinical Trial Registration: Chinese Clinical Trials Registry Identifier: ChiCTR2200055340.
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http://dx.doi.org/10.1007/s10840-022-01322-wDOI Listing
August 2022

Into the future: A pilot study combining imaging with molecular profiling to predict resectability in ovarian cancer.

Gynecol Oncol 2022 Aug 2. Epub 2022 Aug 2.

Department of Quantitative Health Sciences, Division of Epidemiology, Mayo Clinic, Rochester, MN, United States.

Objective: We sought to determine the predictive value of combining tumor molecular subtype and computerized tomography (CT) imaging for surgical outcomes after primary cytoreductive surgery in advanced stage high-grade serous ovarian cancer (HGSOC) patients.

Methods: We identified 129 HGSOC patients who underwent pre-operative CT imaging and post-operative tumor mRNA profiling. A continuous CT-score indicative of overall disease burden was defined based on six imaging measurements of anatomic involvement. Molecular subtypes were derived from mRNA profiling of chemo-naïve tumors and classified as mesenchymal (MES) subtype (36%) or non-MES subtype (64%). Fischer exact tests and multivariate logistic regression examined residual disease and surgical complexity.

Results: Women with higher CT-scores were more likely to have MES subtype tumors (p = 0.014). MES subtypes and a high CT-score were independently predictive of macroscopic disease and high surgical complexity. In multivariate models adjusting for age, stage and American Society of Anesthesiologists (ASA) score, patients with a MES subtype and high CT-score had significantly elevated risk of macroscopic disease (OR = 26.7, 95% CI = [6.42, 187]) and were more likely to undergo high complexity surgery (OR = 9.53, 95% CI = [2.76, 40.6], compared to patients with non-MES tumor and low CT-score.

Conclusion: Preoperative CT imaging combined with tumor molecular subtyping can identify a subset of women unlikely to have resectable disease and likely to require high complexity surgery. Along with other clinical factors, these may refine predictive scores for resection and assist treatment planning. Investigating methods for pre-surgical molecular subtyping is an important next step.
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http://dx.doi.org/10.1016/j.ygyno.2022.07.020DOI Listing
August 2022

An action recognition method for manual acupuncture techniques using a tactile array finger cot.

Comput Biol Med 2022 Jul 12;148:105827. Epub 2022 Jul 12.

School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, 100029, China. Electronic address:

The current measurement systems for the physical parameters (rotation frequency, and amplitude) of Traditional Chinese Medicine (TCM) manual acupuncture tend to cause disturbance and inconvenience in clinical application and do not accurately capture the tactile signals from the physician's finger during manual acupuncture operations. In addition, the literature rarely discusses classification of the four basic manual acupuncture techniques (reinforcing by twirling and rotating (RFTR), reducing by twirling and rotating (RDTR), reinforcing by lifting and thrusting (RFLT), and reducing by lifting and thrusting (RDLT)). To address this problem, we developed a multi-PVDF film-based tactile array finger cot to collect piezoelectric signals from the acupuncturist's finger-needle contact during manual acupuncture operations. In order to recognize the four typical TCM manual acupuncture techniques, we developed a method to capture piezoelectric signals in related "windows" and subsequently extract features to model acupuncture techniques. Next, we created an ensemble learning-based action classifier for manual acupuncture technique recognition. Finally, the proposed classifier was employed to recognize the four types of manual acupuncture techniques performed by 15 TCM physicians based on the piezoelectric signals collected using the tactile array finger cot. Among all the approaches, our proposed feature-based CatBoost ensemble learning model achieved the highest validation accuracy of 99.63% and the highest test accuracy of 92.45%. Moreover, we provide the efficiency and limitations of using this action recognition method.
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http://dx.doi.org/10.1016/j.compbiomed.2022.105827DOI Listing
July 2022

CircJag1 promotes apoptosis of ethylene thiourea-exposed anorectal malformations through sponging miR-137-3p by regulating Sox9 and suppressing Wnt/β-catenin pathway during the hindgut development of rat embryos.

Cell Biol Toxicol 2022 Aug 5. Epub 2022 Aug 5.

Department of Pediatric Surgery, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Heping District, Shenyang, 110004, Liaoning, China.

Anorectal malformations (ARMs) are common birth defects involving congenital structural anomalies of the gastrointestinal tract. As an important component of non-coding RNAs, circular RNAs (circRNAs) widely participate in the digestive system development; however, the specific molecular mechanism of their involvement in ARM occurrence remains obscure. Herein, we generated rat models of ARMs induced by ethylene thiourea. A novel circRNA (circJag1) was screened and identified by RNA-Seq, which is remarkably upregulated in hindgut tissues of ARM rat embryos. In vivo experiments, colocation analysis via fluorescence in situ hybridization, and immunofluorescence further demonstrated that the disordered circJag1/miR-137-3p/Sox9 expression caused a spatiotemporal imbalance in the urorectal septum (URS) of ARMs. In vitro, functional assays confirmed that circJag1 upregulation resulted in the degradation of nuclear β-catenin, C-myc, and Cyclin D1 in rat intestinal epithelial cells, as well as the promotion of apoptosis and suppression of cell proliferation. Mechanistically, dual-luciferase reporter assay and RNA immunoprecipitation assay indicated that circJag1 acted as a miR-137-3p sponge, thereby inhibiting its repressive effect on its target Sox9. Further experiments showed that a loss of Sox9 abolished the circJag1-mediated increase in apoptosis. In conclusion, aberrantly high circJag1 expression promotes epithelial apoptosis by suppressing the canonical Wnt/β-catenin pathway via the miR-137-3p/Sox9 axis, which leads to fusion failure of the URS and cloacal membrane, and eventually contributed to ARMs. Our achievements might boost the comprehension of ARM pathogenesis and could provide a novel candidate target for the development of therapies for ARMs to complement surgical treatment.
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http://dx.doi.org/10.1007/s10565-022-09750-0DOI Listing
August 2022

Efficacy of low-dose corticosteroids in patients with acute respiratory distress syndrome: a prospective observational study.

J Thorac Dis 2022 Jul;14(7):2511-2521

China-Japan Friendship Hospital, Capital Medical University, Beijing, China.

Background: There is still no agreement on whether corticosteroids can reduce mortality in patients with acute respiratory distress syndrome (ARDS). The aim of this study was to investigate the efficacy of low-dose corticosteroid administration in patients with ARDS.

Methods: A prospective observational study of patients with ARDS in 17 hospitals in China was performed between March 2016 and February 2018. Propensity score matching was performed to adjust for differences in baseline characteristics between different groups. The effects of corticosteroids were assessed by using the Kaplan-Meier method and a multivariate Cox regression.

Results: A total of 527 ARDS patients were enrolled in the study. Sixty-five patients (12.3%) were administered low-dose (methylprednisolone ≤1 mg·kg·d) corticosteroids. The median dose was equivalent to 0.67 (0.57-0.81) mg/kg methylprednisolone for a median duration of 10 days. The control group included 224 patients (42.5%) who had never receive corticosteroids. In the matched sample, the hospital mortality rates in the low-dose (n=40) and control groups (n=80) were 27.5% and 42.5% (P=0.110), respectively. The length of hospital stay was significantly longer in the low-dose corticosteroid group than in the control group (24.0 17.0, P=0.002), and the multivariate Cox regression analysis suggested that the low-dose group had a significantly lower risk of death than the control group (HR: 0.48; 95% CI: 0.24-0.97; P=0.040).

Conclusions: The administration of low-dose corticosteroids may reduce mortality in patients with ARDS.
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http://dx.doi.org/10.21037/jtd-21-890DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9344422PMC
July 2022

Effectiveness of motivational interviewing among patients with COPD: A systematic review with meta-analysis and trial sequential analysis of randomized controlled trials.

Patient Educ Couns 2022 Jul 28. Epub 2022 Jul 28.

Department of Respiratory Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China. Electronic address:

Objective: To evaluate the effectiveness of motivational interviewing (MI) for COPD in behavioral changes and health outcomes, and also verify the reliability of results in conjunction with trial sequential analysis and the Grading of Recommendations Assessment, Development, and Evaluation tool.

Methods: Studies that implemented MI interventions for COPD patients were systematically searched by eight databases from inception to December 2021. Study screening, quality assessment, data extraction, and meta-analysis were conducted according to Cochrane standards.

Results: Twenty-one studies involving 2344 patients were included. The results of meta-analyses indicated that MI made significant improvement in self-efficacy, lung function, quality of life, emotion, and COPD-related admission, but not in self-management and exercise capacity. Subgroup analyses found that the intervention duration was inversely associated with effect size for both self-efficacy and negative emotion severity. The trial sequential analysis showed MI improved patients' lung function and reduced COPD-related hospitalization with certainty, but the findings for exercise capacity need to be confirmed by further research.

Conclusions: This systematic review suggested the positive effects of MI on self-efficacy, lung function, quality of life, emotion and COPD-related hospitalization. To make a firm conclusion, more well-designed clinical trials with bigger sample sizes required.

Practice Implications: Clinical and community nurses can use MI for COPD to increase healthy behaviors.

Trial Registration: CRD42021278674.
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http://dx.doi.org/10.1016/j.pec.2022.07.019DOI Listing
July 2022

Nonenzymatic Multiamplified Electrochemical Detection of Medulloblastoma-Relevant MicroRNAs from Cerebrospinal Fluid.

ACS Sens 2022 Aug 4. Epub 2022 Aug 4.

Shanghai Institute of Pediatric Research, Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.

The sensitive analysis of microRNAs (miRNAs) in cerebrospinal fluid (CSF) holds promise for the minimally invasive early diagnosis of brain cancers such as pediatric medulloblastoma but remains challenging due partially to a lack of facile yet sensitive sensing methods. Herein, an enzyme-free triple-signal amplification electrochemical assay for miRNA was developed by integrating the target-triggered cyclic strand-displacement reaction (TCSDR), hybridization chain reaction (HCR), and methylene blue (MB) intercalation. In this assay, the presence of target miRNA (miR-9) initiated the TCSDR and produced primers that triggered the subsequent HCR amplification to generate copious double-stranded DNAs (dsDNAs) on the electrode surface. Intercalation of a large number of MB reporters into the long nicked double helixes of dsDNAs yielded a more enhanced signal of differential pulse voltammetry. The enzyme-free multiple-amplification approach allowed for highly sensitive (detection limit: 6.5 fM) and sequence-specific (single-base mismatch resolution) detection of miR-9 from tumor cells and human CSF with minimal sample consumption (10 μL). Moreover, the clinical utilization of this method was documented by accurate discrimination of five medulloblastoma patients from the nontumoral controls. In light of its sensitivity, specificity, and convenience of use, this electrochemical method was expected to facilitate the early detection of malignant brain tumors.
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http://dx.doi.org/10.1021/acssensors.2c00956DOI Listing
August 2022

Insight into high-performance of La-Ce-MnOx oxides with different calcination temperature for diesel soot combustion.

Environ Technol 2022 Aug 4:1-23. Epub 2022 Aug 4.

Hunan Provincial Key Laboratory of Xiangnan Rare-Precious Metals Compounds Research and Application, Chenzhou 423043, Hunan, China.

A series of La-Ce-MnOx catalysts derived from the precipitation of acetate salt and ammonium carbonate were calcined at different temperatures and applied for the catalytic oxidation of soot from diesel exhausts. The structure states of the as-prepared catalysts and catalytic behavior for soot oxidation were studied by many characterization techniques such as XRD, XANES, N adsorption-desorption, TPR, O-TPD, XPS and TGA. XANES results display most of Mn species are Mn when the samples are calcined at 500 ℃ and 600 ℃. However, for MCLa-700 and MCLa-800 catalysts, the predominance valence is 3 + ions. The MCLa-500 and MCLa-600 catalysts possess higher concentration of surface active oxygen evidenced by H-TPR and soot-TPR. Therefore, the combustion rate of soot over MCLa-600 catalyst is remarkably increased with the T, T and T of 315 ℃, 360 ℃ and 388 ℃.
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http://dx.doi.org/10.1080/09593330.2022.2109994DOI Listing
August 2022

Molecular Surveillance of Antimicrobial Resistance of from Leprosy Patients in Zhejiang Province, China.

Infect Drug Resist 2022 27;15:4029-4036. Epub 2022 Jul 27.

Department of Leprosy Control, Zhejiang Provincial Institute of Dermatology, Huzhou, People's Republic of China.

Purpose: Reports on antimicrobial resistance (AMR) of Mycobacterium () in Zhejiang Province are limited. Thus, this study aimed to investigate the drug resistance of new leprosy cases within several years and analyse the emergence of AMR mutations from Zhejiang Province.

Methods: This study enrolled 34 leprosy cases in Zhejiang Province, China, from 2018 to 2021. Gene mutation of WHO-recommended DRDRs (P1, B and A) and genes of compensatory AMR-associated DRDRs, including nth, A, C, B and 23S rRNA, were detected by amplification. Clinical data analysis was performed to investigate the epidemiological association of leprosy.

Results: Of the 34 samples, 2 (5.9%) strains showed drug resistance, which were mutated to dapsone and ofloxacin, separately. Two single mutations in B were detected in different strains (5.9%), whereas one of the C mutation was also detected in one strain each (2.9%), which were proved to be polymorphs. No correlation of drug resistance proportion was identified in male vs female, nerve vs no nerve involvement, deformity vs no deformity and reaction vs non-reaction cases.

Conclusion: Results showed well control of leprosy patients in Zhejiang Province. Gene mutations of WHO-recommended DRDRs P1 and A confirmed the resistance to dapsone and ofloxacin. Compensatory AMR-associated mutations confirmed to be polymorphs still require further study to determine their phenotypic outcomes in . The results demonstrated that drug-resistant strains are not epidemic in this area. Given the few cases of leprosy, analysing the AMR of in Zhejiang Province more comprehensively is difficult. However, regular MDT treatment and population management in the early stage may contribute to the low prevalence of leprosy.
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http://dx.doi.org/10.2147/IDR.S368682DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9342246PMC
July 2022

Contribution analysis of different electron transfer pathways to methane production in anaerobic digestion coupled with bioelectrochemical system.

Sci Total Environ 2022 Jul 31;849:157745. Epub 2022 Jul 31.

College of Environmental Science and Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, China.

The contribution analysis of different electron transfer pathways to CH production was investigated in bioelectrochemical anaerobic digestion (BEAD). It demonstrates that the indirect interspecies electron transfer (IIET) pathway and the direct interspecies electron transfer (DIET) pathways contributed to 41.7 % and 58.3 % of the CH production in the BEAD reactor, respectively. The DIET pathway was further divided into DIET via electrode (eDIET) and biological DIET (bDIET) in the bulk solution, and contributed 11.1 % and 47.2 % of CH production, respectively. This indicates that the dominant electron transfer pathway for CH production is from the bulk solution, rather than on the polarized electrode. The electroactive microorganisms were well enriched in the bulk solution by the electric field generated between anode and cathode. The enriched electroactive microorganisms significantly improved the CH production in the bulk solution through the bDIET pathway.
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http://dx.doi.org/10.1016/j.scitotenv.2022.157745DOI Listing
July 2022

Three-dimensional ultrashort echo time magnetic resonance imaging in assessment of idiopathic pulmonary fibrosis, in comparison with high-resolution computed tomography.

Quant Imaging Med Surg 2022 Aug;12(8):4176-4189

Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, Capital Medical University, Beijing, China.

Background: We aimed to evaluate the image quality, feasibility, and diagnostic performance of three-dimensional ultrashort echo time magnetic resonance imaging (3D UTE-MRI) to assess idiopathic pulmonary fibrosis (IPF) compared with high-resolution computed tomography (HRCT) and half-Fourier single-shot turbo spin-echo (HASTE) MRI.

Methods: A total of 36 patients with IPF (34 men; mean age: 62±8 years, age range: 43 to 78 years) were prospectively included and underwent HRCT and chest MRI on the same day. Chest MRI was performed with a free-breathing 3D spiral UTE pulse sequence and HASTE sequence on a 1.5 T MRI. Two radiologists independently evaluated the image quality of the HRCT, HASTE, and 3D UTE-MRI. They assessed the representative imaging features of IPF, including honeycombing, reticulation, traction bronchiectasis, and ground-glass opacities. Image quality of the 3D UTE-MRI, HASTE, and HRCT were assessed using a 5-point visual scoring method. Kappa and weighted kappa analysis were used to measure intra- and inter-observer and inter-method agreements. Sensitivity (SE), specificity (SP), and accuracy (AC) were used to assess the performance of 3D UTE-MRI for detecting image features of IPF and monitoring the extent of pulmonary fibrosis. Linear regressions and Bland-Altman plots were generated to assess the correlation and agreement between the assessment of the extent of pulmonary fibrosis made by the 2 observers.

Results: The image quality of HRCT was higher than that of HASTE and UTE-MRI (HRCT UTE-MRI HASTE: 4.9±0.3 4.1±0.7 3.0±0.3; P<0.001). Interobserver agreement of HRCT, HASTE, and 3D UTE-MRI when assessing pulmonary fibrosis was substantial and excellent (HRCT: 0.727≤ κ ≤1, P<0.001; HASTE: 0.654≤ κ ≤1, P<0.001; 3D UTE-MRI: 0.719≤ κ ≤0.824, P<0.001). In addition, reticulation (SE: 97.1%; SP: 100%; AC: 97.2%; κ =0.654), honeycombing (SE: 83.3%; SP: 100%; AC: 86.1%; κ =0.625) patterns, and traction bronchiectasis (SE: 94.1%; SP: 100%; AC: 94.4%, κ =0.640) were also well-visualized on 3D UTE-MRI, which was significantly superior to HASTE. Compared with HRCT, the sensitivity of 3D UTE-MRI to detect signs of pulmonary fibrosis (n=35) was 97.2%. The interobserver agreement in elevation of the extent of pulmonary fibrosis with HRCT and 3D UTE-MRI was R=0.84 (P<0.001) and R=0.84 (P<0.001), respectively. The extent of pulmonary fibrosis assessed with 3D UTE-MRI [median =9, interquartile range (IQR): 6.25 to 10.00] was lower than that from HRCT (median =12, IQR: 9.25 to 13.00; U=320.00, P<0.001); however, they had a positive correlation (R=0.72, P<0.001).

Conclusions: As a radiation-free non-contrast enhanced imaging method, although the image quality of 3D UTE-MRI is inferior to that of HRCT, it has high reproducibility to identify the imaging features of IPF and evaluate the extent of pulmonary fibrosis.
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http://dx.doi.org/10.21037/qims-21-1133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9338383PMC
August 2022

Chemometrics and genome mining reveal an unprecedented family of sugar acid-containing fungal nonribosomal cyclodepsipeptides.

Proc Natl Acad Sci U S A 2022 Aug 1;119(32):e2123379119. Epub 2022 Aug 1.

Biotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, P.R. China.

Xylomyrocins, a unique group of nonribosomal peptide secondary metabolites, were discovered in and spp. fungi by employing a combination of high-resolution tandem mass spectrometry (HRMS/MS)-based chemometrics, comparative genome mining, gene disruption, stable isotope feeding, and chemical complementation techniques. These polyol cyclodepsipeptides all feature an unprecedented d-xylonic acid moiety as part of their macrocyclic scaffold. This biosynthon is derived from d-xylose supplied by xylooligosaccharide catabolic enzymes encoded in the xylomyrocin biosynthetic gene cluster, revealing a novel link between carbohydrate catabolism and nonribosomal peptide biosynthesis. Xylomyrocins from different fungal isolates differ in the number and nature of their amino acid building blocks that are nevertheless incorporated by orthologous nonribosomal peptide synthetase (NRPS) enzymes. Another source of structural diversity is the variable choice of the nucleophile for intramolecular macrocyclic ester formation during xylomyrocin chain termination. This nucleophile is selected from the multiple available alcohol functionalities of the polyol moiety, revealing a surprising polyspecificity for the NRPS terminal condensation domain. Some xylomyrocin congeners also feature methylated amino acid residues in positions where the corresponding NRPS modules lack methyltransferase (M) domains, providing a rare example of promiscuous methylation in the context of an NRPS with an otherwise canonical, collinear biosynthetic program.
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http://dx.doi.org/10.1073/pnas.2123379119DOI Listing
August 2022

Wireless transmission of a 200-m PS-64QAM THz-wave signal using a likelihood-based selection radius-directed equalizer.

Opt Lett 2022 Aug;47(15):3904-3907

Based on a photonics-aided scheme, we achieve an experimental demonstration of a, to the best of our knowledge, record-breaking 200-m terahertz (THz)-wave wireless delivery at 335 GHz with the aid of a pair of high-gain polytetrafluoroethylene (PTFE) lenses. By using a 10-GBaud probabilistically shaped 64-ary quadrature amplitude modulation (PS-64QAM) signal and advanced digital signal processing (DSP) including a likelihood-based selection radius-directed equalizer (LBS-RDE), the single-carrier net bit rate of the wireless delivery reaches 44 Gbit/s. High-speed THz-wave communication with up to 200-m wireless distance is successfully realized based on a photonics-aided scheme for the first time.
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http://dx.doi.org/10.1364/OL.465696DOI Listing
August 2022

Diagnosis and ECMO Treatment of a Critically Ill Patient With Disseminated : A Case Report.

Front Public Health 2022 14;10:938913. Epub 2022 Jul 14.

The Third Department of Critical Care Medicine, Fujian Provincial Center for Critical Care Medicine, Fujian Provincial Key Laboratory of Critical Care Medicine, Fujian Provincial Hospital, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, China.

Background: infection remains a public health concern worldwide. The diagnosis and treatment of disseminated is very difficult, so we shared our experiences and lessons learned in this case report.

Case Presentation: A 36-year-old female with a history of epilepsy presented to our hospital with fever, upper abdominal pain, muscle soreness in limbs for 7 days, and shortness of breath for 4 days. On admission, she presented with acute respiratory distress syndrome (ARDS) and liver dysfunction. Due to the critical nature of her clinical presentation, the patient was admitted directly to the Intensive Care Unit (ICU), received mechanical ventilation in prone position and VV-ECMO treatment. Her condition improved gradually, and the ECMO was removed after 7 days and she was weaned off the ventilator after 8 days. However, her fever recurred and she underwent PET-CT examination, liver contrast ultrasound, acid-fast staining and second-generation sequencing of cerebrospinal fluid, which confirmed infection.

Conclusion: This case report briefly described the treatment and diagnosis of a critically ill patient with intra and extra-pulmonary tuberculosis infection. Timely and appropriate treatment is crucial to save lives, but the timing of ECMO treatment needs to be carefully considered for patients with ARDS caused by tuberculosis.
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http://dx.doi.org/10.3389/fpubh.2022.938913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9330379PMC
August 2022

An Inducible Nitric Oxide Synthase Dimerization Inhibitor Prevents the Progression of Osteoarthritis.

Front Pharmacol 2022 15;13:861183. Epub 2022 Jul 15.

Department of Orthopedic, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.

Osteoarthritis (OA) is a degenerative joint disease. Excessive nitric oxide (NO) mediates the chondrocyte inflammatory response, apoptosis, and extracellular matrix (ECM) degradation during the occurrence and development of OA. NO in chondrocytes is mainly produced by inducible nitric oxide synthase (iNOS). The aim of this study was to design and synthesize an iNOS dimerization inhibitor and evaluate its effects on chondrocyte inflammation and articular cartilage injury in OA via and experiments. The title compound 22o was designed, synthesized, and screened based on a previous study. The effects of different concentrations (5, 10, and 20 μM) of compound 22o on chondrocyte inflammatory response and ECM anabolism or catabolism were evaluated by Western blot and real-time quantitative reverse transcription-polymerase chain reaction using the rat chondrocyte model of IL-1β-induced OA. Furthermore, different doses (40 and 80 mg/kg) of compound 22o were administered by gavage to a rat OA model induced by anterior cruciate ligament transection (ACLT), and their protective effects on the articular cartilage were evaluated by histopathology and immunohistochemistry. Compound 22o showed effective iNOS inhibitory activity by inhibiting the dimerization of iNOS. It inhibited the IL-1β-induced expression of cyclooxygenase-2 (COX-2) and matrix metalloproteinase 3 (MMP3) in the chondrocytes, decreased NO production, and significantly increased the expression levels of the ECM anabolic markers, aggrecan (ACAN), and collagen type II (COL2A1). Gavage with compound 22o was found to be effective in the rat OA model induced by ACLT, wherein it regulated the anabolism and catabolism and exerted a protective effect on the articular cartilage. Compound 22o inhibited the inflammatory response and catabolism of the chondrocytes and reduced articular cartilage injury in the rat OA model, indicating its potential as a disease-modifying OA drug.
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http://dx.doi.org/10.3389/fphar.2022.861183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9334866PMC
July 2022

Multiple microplastics induced stress on anaerobic granular sludge and an effectively overcoming strategy using hydrochar.

Water Res 2022 Jul 25;222:118895. Epub 2022 Jul 25.

Centre for Technology in Water and Wastewater, School of Civil and Environmental Engineering, University of Technology Sydney, Sydney, NSW 2007, Australia. Electronic address:

Previous studies mostly focused on the responses of anaerobic granular sludge (AGS) to one kind of microplastics during wastewater treatment. However, a wide variety of microplastics has been detected in wastewater. The multiple microplastics induced stress on AGS and the effectively mitigating strategy still remain unavailable. Herein, this work comprehensively excavated the influences of multiple microplastics (i.e., polyethylene terephthalate (PET), polystyrene (PS), polyethylene (PE) and polypropylene (PP)) coexisting in the wastewater on AGS system from macroscopic to microcosmic aspects. Experimental results illustrated that microplastics decreased AGS granule size, increased cell inactivation and caused deteriorative methane recovery from wastewater. As such, this study then put great emphasis on proposing a mitigating strategy using hydrochar and disclosing the role of hydrochar in overcoming the stress induced by coexisting microplastics to AGS system. Physiological characterization and microbial community analysis demonstrated that hydrochar effectively mitigated the reductions in methane production by 50.6% and cell viability by 68.8% of microplastics-bearing AGS and reduced the toxicity of microplastics to microbial community in the AGS. Mechanisms investigation by fluorescence tagging and excitation emission matrix fluorescence spectroscopy with fluorescence regional integration (EEM-FRI) analysis revealed that hydrochar adsorbed/accumulated microplastics and enhanced microplastics-bearing AGS to secrete extracellular polymeric substance (EPS) with more humic acid generation, thus reducing the direct contact between microplastics and AGS. In addition, hydrochar weakened the AGS intracellular oxidative stress induced by microplastics, thereby completely eliminating the inhibition of microplastics on acidification efficiency of AGS, and partially mitigating the suppression on methanation.
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http://dx.doi.org/10.1016/j.watres.2022.118895DOI Listing
July 2022

PO2RDF: representation of real-world data for precision oncology using resource description framework.

BMC Med Genomics 2022 07 30;15(1):167. Epub 2022 Jul 30.

Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.

Background: Next-generation sequencing provides comprehensive information about individuals' genetic makeup and is commonplace in precision oncology practice. Due to the heterogeneity of individual patient's disease conditions and treatment journeys, not all targeted therapies were initiated despite actionable mutations. To better understand and support the clinical decision-making process in precision oncology, there is a need to examine real-world associations between patients' genetic information and treatment choices.

Methods: To fill the gap of insufficient use of real-world data (RWD) in electronic health records (EHRs), we generated a single Resource Description Framework (RDF) resource, called PO2RDF (precision oncology to RDF), by integrating information regarding genes, variants, diseases, and drugs from genetic reports and EHRs.

Results: There are a total 2,309,014 triples contained in the PO2RDF. Among them, 32,815 triples are related to Gene, 34,695 triples are related to Variant, 8,787 triples are related to Disease, 26,154 triples are related to Drug. We performed two use case analyses to demonstrate the usability of the PO2RDF: (1) we examined real-world associations between EGFR mutations and targeted therapies to confirm existing knowledge and detect off-label use. (2) We examined differences in prognosis for lung cancer patients with/without TP53 mutations.

Conclusions: In conclusion, our work proposed to use RDF to organize and distribute clinical RWD that is otherwise inaccessible externally. Our work serves as a pilot study that will lead to new clinical applications and could ultimately stimulate progress in the field of precision oncology.
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http://dx.doi.org/10.1186/s12920-022-01314-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9338627PMC
July 2022

Lineage-specific rearrangement of chromatin loops and epigenomic features during adipocytes and osteoblasts commitment.

Cell Death Differ 2022 Jul 29. Epub 2022 Jul 29.

Biomedical Informatics & Genomics Center, Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, Shaanxi, 710049, P. R. China.

Human mesenchymal stem cells (hMSCs) can be differentiated into adipocytes and osteoblasts. The processes are driven by the rewiring of chromatin architectures and transcriptomic/epigenomic changes. Here, we induced hMSCs to adipogenic and osteogenic differentiation, and performed 2 kb resolution Hi-C experiments for chromatin loops detection. We also generated matched RNA-seq, ChIP-seq and ATAC-seq data for integrative analysis. After comprehensively comparing adipogenesis and osteogenesis, we quantitatively identified lineage-specific loops and screened out lineage-specific enhancers and open chromatin. We reveal that lineage-specific loops can activate gene expression and facilitate cell commitment through combining enhancers and accessible chromatin in a lineage-specific manner. We finally proposed loop-mediated regulatory networks and identified the controlling factors for adipocytes and osteoblasts determination. Functional experiments validated the lineage-specific regulation networks towards IRS2 and RUNX2 that are associated with adipogenesis and osteogenesis, respectively. These results are expected to help better understand the chromatin conformation determinants of hMSCs fate commitment.
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http://dx.doi.org/10.1038/s41418-022-01035-7DOI Listing
July 2022

Disturbances of Vaginal Microbiome Composition in Human Papillomavirus Infection and Cervical Carcinogenesis: A Qualitative Systematic Review.

Front Oncol 2022 12;12:941741. Epub 2022 Jul 12.

Department of Gynecology and Obstetrics, Tianjin Medical University General Hospital, Tianjin, China.

Background: Emerging evidence has demonstrated a close association between perturbations in vaginal microbiota composition in women and human papillomavirus (HPV) infection, cervical lesions, and cervical cancer (Ca); however, these findings are highly heterogeneous and inconclusive.

Aim: To perform a comprehensive systematic review of the global disturbance in the vaginal microbiota, specifically in women with HPV-associated cervical diseases, and to further conduct within- and across-disease comparisons.

Method: Twenty-two records were identified in a systematic literature search of PubMed, Web of Science, and Embase up to February 28, 2022. We extracted microbial changes at the community (alpha and beta diversity) and taxonomic (relative abundance) levels. Within- and across-disease findings on the relative abundance of taxonomic assignments were qualitatively synthesized.

Results: Generally, significantly higher alpha diversity was observed for HPV infection, cervical lesions, and/or cancer patients than in controls, and significant differences within beta diversity were observed for the overall microbial composition across samples. In within-disease comparisons, the genera , , , , and showed the greatest abundances with HPV infection; and showed inconsistent abundance with HPV infection, and was observed in Ca. Across diseases, we find increased levels of and varying levels of were shared across HPV infections, high-grade squamous intraepithelial lesions, and Ca, whereas varied depending on the HPV-related disease subtype.

Conclusions: This systematic review reports that vaginal microbiome disturbances are correlated to the depletion of , enrichment of anaerobes, and increased abundance of aerobic bacteria in HPV infection and related cervical diseases. Moreover, may exert either protective or pathogenic effects on different HPV-related diseases.
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http://dx.doi.org/10.3389/fonc.2022.941741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9316588PMC
July 2022

Stress distribution patterns during the gait cycle in patients with anterior femoral notching following total knee replacement.

BMC Musculoskelet Disord 2022 Jul 28;23(1):718. Epub 2022 Jul 28.

Department of Orthopedic Surgery, Affiliated Hospital of Xuzhou Medical University, 99 Huaihai Road, 221002, Xuzhou, Jiangsu, China.

Background: Anterior femoral notching (AFN) is a severe complication of total knee replacement (TKR), which in a percentage of patients may lead to fractures after surgery. The purpose of this study was to investigate the stress distribution in patients with AFN and the safety depth of AFN during the gait cycle.

Methods: We performed a finite element (FE) analysis to analyse the mechanics around the femur during the gait cycle in patients with AFN. An adult volunteer was selected as the basis of the model. The TKR models were established in the 3D reconstruction software to simulate the AFN model during the TKR process, and the 1 mm, 2 mm, 3 mm, 4 mm, and 5 mm AFN models were established, after which the prosthesis was assembled. Three key points of the gait cycle (0°, 22°, and 48°) were selected for the analysis.

Results: The stress on each osteotomy surface was stable in the 0° phase. In the 22° phase, the maximum equivalent stress at 3 mm was observed. In the 48° phase, with the increase in notch depth, each osteotomy surface showed an overall increasing trend, the stress range was more extended, and the stress was more concentrated. Moreover, the maximum equivalent force value (158.3 MPa) exceeded the yield strength (115.1 MPa) of the femur when the depth of the notch was ≥ 3 mm.

Conclusions: During the gait cycle, if there is an anterior femoral cortical notch ≥ 3 mm, the stress will be significantly increased, especially at 22° and 48°. The maximum equivalent stress exceeded the femoral yield strength and may increase the risk of periprosthetic fractures.
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http://dx.doi.org/10.1186/s12891-022-05643-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9330681PMC
July 2022

Fast peroxydisulfate oxidation of the antibiotic norfloxacin catalyzed by cyanobacterial biochar.

J Hazard Mater 2022 Jul 21;439:129655. Epub 2022 Jul 21.

Department of Plant and Environmental Sciences, University of Copenhagen, Thorvaldsensvej 40, DK-1871 Frederiksberg C, Denmark.

Peroxydisulfate (PDS) is a common oxidant for organic contaminant remediation. PDS is typically activated by metal catalysts to generate reactive radicals. Unfortunately, as radicals are non-selective and metal catalysts may cause secondary contamination, alternative selective non-radical pathways and non-metal catalysts need attention. Here we investigated PDS oxidation of commonly detected antibiotic Norfloxacin (NOR) using cyanobacterial nitrogen rich biochars (CBs) as catalysts. NOR was fully degraded by CB pyrolysed at 950 °C (CB950) within 120 min. CB950 caused threefold faster degradation than low pyrolysis temperature (PT) CBs and achieved a maximum surface area normalized rate constant of 4.38 × 10 min m L compared to widely used metal catalysts. CB950 maintained full reactivity after four repeated uses. High defluorination (82%) and mineralization (>82%) were observed for CB950/PDS. CBs were active over a broad pH range (3-10), but with twice as high rates under alkaline compared with neutral conditions. NOR is degraded by organic, OH and SO radicals in low PT CBs/PDS systems, where the presence of Mn promotes radical generation. Electron transfer reactions with radicals supplemented dominate high PT CBs/PDS systems. This study demonstrates high PT biochars from algal bloom biomass may find use as catalysts for organic contaminant oxidation.
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http://dx.doi.org/10.1016/j.jhazmat.2022.129655DOI Listing
July 2022
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