Charles W Luetje

Charles W Luetje

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Charles W Luetje

Charles W Luetje

Publications by authors named "Charles W Luetje"

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Trading amino acids at the aphid- symbiotic interface.

Proc Natl Acad Sci U S A 2019 Aug 23;116(32):16003-16011. Epub 2019 Jul 23.

Institute for Cell & Molecular Biosciences, Faculty of Medical Sciences, Newcastle University, NE2 4HH, Newcastle upon Tyne, United Kingdom;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1906223116
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http://dx.doi.org/10.1073/pnas.1906223116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690024PMC
August 2019

Use of machine learning to identify novel, behaviorally active antagonists of the insect odorant receptor co-receptor (Orco) subunit.

Sci Rep 2019 Mar 11;9(1):4055. Epub 2019 Mar 11.

Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, Florida, 33136, USA.

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http://dx.doi.org/10.1038/s41598-019-40640-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411751PMC
March 2019

Mutant cycle analysis identifies a ligand interaction site in an odorant receptor of the malaria vector .

J Biol Chem 2017 11 29;292(46):18916-18923. Epub 2017 Sep 29.

From the Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, Florida 33101

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http://dx.doi.org/10.1074/jbc.M117.810374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5704475PMC
November 2017

Mammalian odorant receptor tuning breadth persists across distinct odorant panels.

PLoS One 2017 25;12(9):e0185329. Epub 2017 Sep 25.

Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, Florida, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0185329PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612731PMC
October 2017

Inhibition of insect olfactory behavior by an airborne antagonist of the insect odorant receptor co-receptor subunit.

PLoS One 2017 31;12(5):e0177454. Epub 2017 May 31.

Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, Florida, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0177454PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5451006PMC
September 2017

Functional and Nonfunctional Forms of CquiOR91, an Odorant Selectivity Subunit of Culex quinquefasciatus.

Chem Senses 2017 05;42(4):333-341

Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, R-189, PO Box 016189, Miami, FL 33101, USA and.

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https://academic.oup.com/chemse/article/42/4/333/3061208
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http://dx.doi.org/10.1093/chemse/bjx011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964367PMC
May 2017

Synthesis, Nicotinic Acetylcholine Receptor Binding, and in Vitro and in Vivo Pharmacological Properties of 2'-Fluoro-(substituted thiophenyl)deschloroepibatidine Analogues.

ACS Chem Neurosci 2017 01 20;8(1):115-127. Epub 2016 Oct 20.

Research Triangle Institute , P.O. Box 12194, Research Triangle Park, North Carolina 27709, United States.

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http://dx.doi.org/10.1021/acschemneuro.6b00252DOI Listing
January 2017

Synthesis, Nicotinic Acetylcholine Binding, and in Vitro and in Vivo Pharmacological Properties of 2'-Fluoro-(carbamoylpyridinyl)deschloroepibatidine Analogues.

ACS Chem Neurosci 2016 07 19;7(7):1004-12. Epub 2016 May 19.

Research Triangle Institute , P.O. Box 12194, Research Triangle Park, North Carolina 27709, United States.

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http://dx.doi.org/10.1021/acschemneuro.6b00107DOI Listing
July 2016

Proton-dependent glutamine uptake by aphid bacteriocyte amino acid transporter ApGLNT1.

Biochim Biophys Acta 2015 Oct 29;1848(10 Pt A):2085-91. Epub 2015 May 29.

Department of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbamem.2015.05.019DOI Listing
October 2015

Synthesis, nicotinic acetylcholine receptor binding, in vitro and in vivo pharmacology properties of 3'-(substituted pyridinyl)-deschloroepibatidine analogs.

Bioorg Med Chem 2015 Sep 17;23(17):5693-701. Epub 2015 Jul 17.

Center for Drug Discovery, Research Triangle Institute, PO Box 12194, Research Triangle Park, NC 27709-2194, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2015.07.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4554999PMC
September 2015

Receptive range analysis of a mouse odorant receptor subfamily.

J Neurochem 2015 Jul 25;134(1):47-55. Epub 2015 Mar 25.

Department of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami, Miami, Florida, USA.

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http://doi.wiley.com/10.1111/jnc.13095
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http://dx.doi.org/10.1111/jnc.13095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4472571PMC
July 2015

Discovery of novel ligands for mouse olfactory receptor MOR42-3 using an in silico screening approach and in vitro validation.

PLoS One 2014 17;9(3):e92064. Epub 2014 Mar 17.

Department of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami, Miami, Florida, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0092064PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956865PMC
November 2014

A determinant of odorant specificity is located at the extracellular loop 2-transmembrane domain 4 interface of an Anopheles gambiae odorant receptor subunit.

Chem Senses 2014 Nov 30;39(9):761-9. Epub 2014 Sep 30.

Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL 33101, USA and

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http://dx.doi.org/10.1093/chemse/bju048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201304PMC
November 2014

Phenylthiophenecarboxamide antagonists of the olfactory receptor co-receptor subunit from a mosquito.

PLoS One 2013 17;8(12):e84575. Epub 2013 Dec 17.

Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, Florida, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0084575PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3866151PMC
September 2014

Trace amines inhibit insect odorant receptor function through antagonism of the co-receptor subunit.

F1000Res 2014 3;3:84. Epub 2014 Apr 3.

Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL, 33101, USA.

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http://dx.doi.org/10.12688/f1000research.3825.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4097363PMC
July 2014

Synthesis, nicotinic acetylcholine receptor binding, and antinociceptive properties of 2'-fluoro-3'-(substituted pyridinyl)-7-deschloroepibatidine analogues.

J Med Chem 2014 Feb 28;57(3):836-48. Epub 2014 Jan 28.

Center for Organic and Medicinal Chemistry, Research Triangle Institute , P.O. Box 12194, Research Triangle Park, North Carolina 27709, United States.

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http://dx.doi.org/10.1021/jm401602pDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983394PMC
February 2014

Aphid amino acid transporter regulates glutamine supply to intracellular bacterial symbionts.

Proc Natl Acad Sci U S A 2014 Jan 23;111(1):320-5. Epub 2013 Dec 23.

Department of Biology, University of Miami, Coral Gables, FL 33146.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1306068111
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http://dx.doi.org/10.1073/pnas.1306068111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3890774PMC
January 2014

Functional assay of mammalian and insect olfactory receptors using Xenopus oocytes.

Methods Mol Biol 2013 ;1003:187-202

Department of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami, Miami, FL, USA.

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http://dx.doi.org/10.1007/978-1-62703-377-0_14DOI Listing
September 2013

Silent, generic and plant kairomone sensitive odorant receptors from the Southern house mosquito.

J Insect Physiol 2013 Sep 19;59(9):961-6. Epub 2013 Jul 19.

Department of Molecular and Cellular Biology, University of California, Davis, CA 95616, USA.

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http://dx.doi.org/10.1016/j.jinsphys.2013.07.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3800014PMC
September 2013

Receptors: Chemical courtship in mice.

Authors:
Charles W Luetje

Nat Chem Biol 2013 Mar;9(3):140-1

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http://dx.doi.org/10.1038/nchembio.1180DOI Listing
March 2013

Identification of new agonists and antagonists of the insect odorant receptor co-receptor subunit.

PLoS One 2012 8;7(5):e36784. Epub 2012 May 8.

Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, Florida, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0036784PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3348135PMC
September 2012

Sequencing and characterizing odorant receptors of the cerambycid beetle Megacyllene caryae.

Insect Biochem Mol Biol 2012 Jul 5;42(7):499-505. Epub 2012 Apr 5.

Department of Entomology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

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http://dx.doi.org/10.1016/j.ibmb.2012.03.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361640PMC
July 2012

A broadly tuned mouse odorant receptor that detects nitrotoluenes.

J Neurochem 2012 Jun 19;121(6):881-90. Epub 2012 Apr 19.

Department of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami, Miami, Florida 33101, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2012.07740.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371092PMC
June 2012

RegIIA: an α4/7-conotoxin from the venom of Conus regius that potently blocks α3β4 nAChRs.

Biochem Pharmacol 2012 Feb 16;83(3):419-26. Epub 2011 Nov 16.

Department of Chemistry & Biochemistry, Florida Atlantic University, 777 Glades Rd., Boca Raton, FL 33431, USA.

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http://dx.doi.org/10.1016/j.bcp.2011.11.006DOI Listing
February 2012

Subunit contributions to insect olfactory receptor function: channel block and odorant recognition.

Chem Senses 2011 Nov 15;36(9):781-90. Epub 2011 Jun 15.

Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, FL 33101, USA.

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http://dx.doi.org/10.1093/chemse/bjr053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195787PMC
November 2011

Odorant receptor from the southern house mosquito narrowly tuned to the oviposition attractant skatole.

J Chem Ecol 2010 Aug 11;36(8):797-800. Epub 2010 Jul 11.

Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL, USA.

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http://dx.doi.org/10.1007/s10886-010-9828-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2908433PMC
August 2010

Transmembrane segment 3 of Drosophila melanogaster odorant receptor subunit 85b contributes to ligand-receptor interactions.

J Biol Chem 2010 Apr 10;285(16):11854-62. Epub 2010 Feb 10.

Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, Florida 33101, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M109.058321
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http://dx.doi.org/10.1074/jbc.M109.058321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852922PMC
April 2010

An odorant receptor from the southern house mosquito Culex pipiens quinquefasciatus sensitive to oviposition attractants.

PLoS One 2010 Apr 8;5(4):e10090. Epub 2010 Apr 8.

Department of Entomology, University of California Davis, Davis, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0010090PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851645PMC
April 2010

Molecular receptive range variation among mouse odorant receptors for aliphatic carboxylic acids.

J Neurochem 2009 Apr 23;109(1):193-202. Epub 2009 Feb 23.

Department of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami, Miami, Florida 33101, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2009.05925.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670241PMC
April 2009

Zinc potentiates neuronal nicotinic receptors by increasing burst duration.

J Neurophysiol 2008 Feb 19;99(2):999-1007. Epub 2007 Dec 19.

Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL 33101, USA.

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http://dx.doi.org/10.1152/jn.01040.2007DOI Listing
February 2008

Genetic elucidation of human hyperosmia to isovaleric acid.

PLoS Biol 2007 Oct;5(11):e284

Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.

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http://dx.doi.org/10.1371/journal.pbio.0050284DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2043052PMC
October 2007

A honey bee odorant receptor for the queen substance 9-oxo-2-decenoic acid.

Proc Natl Acad Sci U S A 2007 Sep 30;104(36):14383-8. Epub 2007 Aug 30.

Department of Entomology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

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http://dx.doi.org/10.1073/pnas.0705459104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1964862PMC
September 2007

The molecular basis for ligand specificity in a mouse olfactory receptor: a network of functionally important residues.

J Biol Chem 2007 Jan 17;282(2):1216-24. Epub 2006 Nov 17.

Department of Molecular and Cellular Pharmacology, University of Miami, Miami, Florida 33101, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M609355200
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http://dx.doi.org/10.1074/jbc.M609355200DOI Listing
January 2007

Varenicline is a partial agonist at alpha4beta2 and a full agonist at alpha7 neuronal nicotinic receptors.

Mol Pharmacol 2006 Sep 9;70(3):801-5. Epub 2006 Jun 9.

Department of Molecular and Cellular Pharmacology (R-189), University of Miami Miller School of Medicine, PO Box 016189, Miami, FL 33101, USA.

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http://dx.doi.org/10.1124/mol.106.025130DOI Listing
September 2006

Determinants of alpha-conotoxin BuIA selectivity on the nicotinic acetylcholine receptor beta subunit.

Biochemistry 2006 Sep;45(37):11200-7

Department of Biology, University of Utah, Salt Lake City 84112-0840, USA.

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http://dx.doi.org/10.1021/bi0611715DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824546PMC
September 2006

Functional analysis of a mammalian odorant receptor subfamily.

J Neurochem 2006 Jun 5;97(5):1506-18. Epub 2006 Apr 5.

Department of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami, Miami, Florida 33101, USA.

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http://doi.wiley.com/10.1111/j.1471-4159.2006.03859.x
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http://dx.doi.org/10.1111/j.1471-4159.2006.03859.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096696PMC
June 2006

Determinants of zinc potentiation on the alpha4 subunit of neuronal nicotinic receptors.

Mol Pharmacol 2006 Jan 27;69(1):27-36. Epub 2005 Sep 27.

Department of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami, Miami, FL 33101, USA.

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http://dx.doi.org/10.1124/mol.105.015164DOI Listing
January 2006

Getting past the asterisk: the subunit composition of presynaptic nicotinic receptors that modulate striatal dopamine release.

Authors:
Charles W Luetje

Mol Pharmacol 2004 Jun;65(6):1333-5

Department of Molecular and Cellular Pharmacology, University of Miami School of Medicine, Miami, Florida 33101, USA.

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http://dx.doi.org/10.1124/mol.65.6.1333DOI Listing
June 2004

Hormone resistance: it's SMRT to fight repression.

Endocrinology 2004 Apr;145(4):1525-6

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http://dx.doi.org/10.1210/en.2004-0003DOI Listing
April 2004

GABAA receptor subunit mRNA expression in cultured embryonic and adult human dorsal root ganglion neurons.

Brain Res Dev Brain Res 2004 Apr;149(2):143-51

Department of Molecular and Cellular Pharmacology, R-189, Miami Project to Cure Paralysis, University of Miami School of Medicine, Miami, FL 33101, USA.

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http://dx.doi.org/10.1016/j.devbrainres.2004.01.001DOI Listing
April 2004

Determinants of potency on alpha-conotoxin MII, a peptide antagonist of neuronal nicotinic receptors.

Biochemistry 2004 Mar;43(10):2732-7

Department of Molecular and Cellular Pharmacology, University of Miami School of Medicine, P.O. Box 016189, Miami, Florida 33101, USA.

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http://dx.doi.org/10.1021/bi036180hDOI Listing
March 2004

Tyrosine phosphorylation of rod cyclic nucleotide-gated channels switches off Ca2+/calmodulin inhibition.

J Neurosci 2003 Nov;23(31):10100-6

Deparment of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6740857PMC
November 2003

Subunit contributions to phosphorylation-dependent modulation of bovine rod cyclic nucleotide-gated channels.

J Physiol 2003 Oct;552(Pt 2):345-56

Deparment of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.

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http://dx.doi.org/10.1113/jphysiol.2003.047167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2343370PMC
October 2003

Identification of residues that confer alpha-conotoxin-PnIA sensitivity on the alpha 3 subunit of neuronal nicotinic acetylcholine receptors.

J Pharmacol Exp Ther 2003 Aug 6;306(2):664-70. Epub 2003 May 6.

Department of Molecular and Cellular Pharmacology, University of Miami School of Medicine, Miami, Florida 33101, USA.

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http://dx.doi.org/10.1124/jpet.103.051656DOI Listing
August 2003

Effects of pyridine ring substitutions on affinity, efficacy, and subtype selectivity of neuronal nicotinic receptor agonist epibatidine.

J Pharmacol Exp Ther 2002 Sep;302(3):1246-52

Department of Molecular and Cellular Pharmacology, University of Miami School of Medicine, Miami, FL 33101, USA.

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http://dx.doi.org/10.1124/jpet.102.035899DOI Listing
September 2002

Modulation of neuronal nicotinic acetylcholine receptors by mercury.

J Pharmacol Exp Ther 2002 Aug;302(2):560-7

Department of Molecular and Cellular Pharmacology, University of Miami School of Medicine, PO Box 016189, Miami, FL 33101, USA.

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http://jpet.aspetjournals.org/cgi/doi/10.1124/jpet.102.03515
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http://dx.doi.org/10.1124/jpet.102.035154DOI Listing
August 2002