Publications by authors named "Cem Gabay"

100Publications

Impact of Acute Inflammation on Cytochromes P450 Activity Assessed by the Geneva Cocktail.

Clin Pharmacol Ther 2020 Dec 20. Epub 2020 Dec 20.

Division of Clinical Pharmacology and Toxicology, Department of Anaesthesiology, Pharmacology, Intensive Care and Emergency Medicine, Geneva University Hospitals, Geneva, Switzerland.

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December 2020

Travel patterns, risk behaviour and health problems of travellers with rheumatic diseases compared to controls: A multi-centre, observational study.

Travel Med Infect Dis 2020 Nov - Dec;38:101818. Epub 2020 Jul 23.

Department of Public Health & Global Health, Division of Infectious Diseases, Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland; Department of Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine & I. Department of Medicine University Medical Center Hamburg-Eppendorf, Hamburg, Germany. Electronic address:

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July 2020

Production of IL-18 Binding Protein by Radiosensitive and Radioresistant Cells in CpG-Induced Macrophage Activation Syndrome.

J Immunol 2020 Aug 10;205(4):1167-1175. Epub 2020 Jul 10.

Department of Pathology and Immunology, School of Medicine, University of Geneva, CH-1211 Geneva 4, Switzerland; and

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August 2020

Randomized clinical trials in ANCA-associated vasculitis: a systematic analysis of the WHO - International Clinical Trials Registry Platform.

Orphanet J Rare Dis 2020 05 29;15(1):130. Epub 2020 May 29.

Division of Rheumatology, Department of Medicine, Geneva University Hospitals, Geneva, Switzerland.

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May 2020

IL-36 signaling in keratinocytes controls early IL-23 production in psoriasis-like dermatitis.

Life Sci Alliance 2020 06 28;3(6). Epub 2020 Apr 28.

Department of Pathology-Immunology, University of Geneva Faculty of Medicine, Geneva, Switzerland

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June 2020

Les progrès en rhumatologie continuent d’être rapides.

Rev Med Suisse 2020 Mar;16(685):475

Médecin-chef de service, Service de rhumatologie, HUG, Genève.

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March 2020

Intracellular IL-1 Receptor Antagonist Isoform 1 Released from Keratinocytes upon Cell Death Acts as an Inhibitor for the Alarmin IL-1α.

J Immunol 2020 02 13;204(4):967-979. Epub 2020 Jan 13.

Department of Pathology and Immunology, School of Medicine, University of Geneva, 1211 Geneva 4, Switzerland; and

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February 2020

IL-18 as therapeutic target in a patient with resistant systemic juvenile idiopathic arthritis and recurrent macrophage activation syndrome.

Rheumatology (Oxford) 2020 Feb;59(2):442-445

Division of Rheumatology, Cincinnati Children's Hospital Medical Center and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH.

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February 2020

Long-term therapy with anakinra in hidradenitis suppurativa in three patients.

Int J Dermatol 2019 Nov 29;58(11):e208-e209. Epub 2019 Jul 29.

Department of Dermatology, University Hospital of Geneva, Geneva, Switzerland.

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November 2019

IL-18 as a biomarker linking systemic juvenile idiopathic arthritis and macrophage activation syndrome.

Rheumatology (Oxford) 2020 02;59(2):361-366

Division of Rheumatology, Cincinnati Children's Hospital Medical Center and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH.

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February 2020

Inadequate reporting of concomitant medications in rheumatology randomized controlled trials of pharmacologic interventions.

Semin Arthritis Rheum 2019 12 16;49(3):453-458. Epub 2019 Mar 16.

Methods of Therapeutic Evaluation Of Chronic Diseases (METHODS) team, INSERM, UMR 1153, Epidemiology and Biostatistics Sorbonne Paris Cité Research Center (CRESS), 1 Place du Parvis Notre Dame, 75004 Paris, France; Assistance Publique des Hôpitaux de Paris, Centre d'Epidémiologie Clinique, Hôpital Hôtel Dieu, Paris, France; Cochrane France, Paris, France; Department of Epidemiology, Columbia University, Mailman School of Public Health, New York, NY, United States.

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December 2019

[Inflammatory arthritides pathotypes].

Rev Med Suisse 2019 Mar;15(641):522-527

Service de rhumatologie, HUG, 1211 Genève 14.

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March 2019

Polyarthrite rhumatoïde : ce qui a changé et ce qu’il reste encore à faire.

Rev Med Suisse 2019 Mar;15(641):519-520

Service de rhumatologie, CHUV, Lausanne.

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March 2019

in individuals at risk for rheumatoid arthritis.

Ann Rheum Dis 2019 05 13;78(5):590-593. Epub 2019 Feb 13.

Department of Microbial Immune Regulation, Helmholtz Centre for Infection Research, Braunschweig, Germany

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May 2019

Response to: 'When binary and continuous responses disagree' by Dr Ouyang.

Ann Rheum Dis 2020 04 30;79(4):e39. Epub 2019 Jan 30.

Division of Rheumatology, Geneva University Hospitals, Geneva, Switzerland

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April 2020

Role of reproductive and menopausal factors in functional and structural progression of rheumatoid arthritis: results from the SCQM cohort.

Rheumatology (Oxford) 2019 03;58(3):432-440

Department of Internal Medicine Specialties, Division of Rheumatology, University Hospitals of Geneva, Switzerland.

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March 2019

Prolonged treatment with Tadekinig alfa in adult-onset Still's disease.

Ann Rheum Dis 2020 01 23;79(1):e10. Epub 2018 Oct 23.

Division of Rheumatology, Department of Internal Medicine Specialties, University of Geneva, Geneva, Switzerland

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January 2020

Biological agents in the management of adult-onset Still's disease.

Joint Bone Spine 2019 01 6;86(1):5-7. Epub 2018 Apr 6.

Division of Rheumatology, Department of Internal Medicine Specialties, University Hospitals of Geneva, 26 Avenue de Beau-Séjour, 1211 Geneva 14, Switzerland. Electronic address:

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January 2019

[Management of septic arthritis].

Rev Med Suisse 2018 Mar;14(597):516-521

Service des maladies infectieuses, HUG, 1211 Genève 14.

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March 2018

L’homme et les microbes : les deux faces d’une même médaille.

Rev Med Suisse 2018 Mar;14(597):507

Service de rhumatologie, HUG, Genève.

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March 2018

β Cell-Specific Deletion of the IL-1 Receptor Antagonist Impairs β Cell Proliferation and Insulin Secretion.

Cell Rep 2018 02;22(7):1774-1786

Department of Endocrinology, Diabetes, and Metabolism, University Hospital Basel, 4031 Basel, Switzerland; Department of Biomedicine, University of Basel, 4031 Basel, Switzerland.

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February 2018

Nanocrystal-Polymer Particles: Extended Delivery Carriers for Osteoarthritis Treatment.

Small 2018 02 12;14(8). Epub 2018 Jan 12.

School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, CH-1211, Geneva 4, Switzerland.

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February 2018

Unopposed IL-18 signaling leads to severe TLR9-induced macrophage activation syndrome in mice.

Blood 2018 03 2;131(13):1430-1441. Epub 2018 Jan 2.

Division of Rheumatology, Department of Internal Medicine Specialties, University Hospital, Geneva, Switzerland; and Department of Pathology-Immunology, University of Geneva School of Medicine, Geneva, Switzerland.

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March 2018

Regulation and function of interleukin-36 cytokines.

Immunol Rev 2018 01;281(1):169-178

Division of Rheumatology, Department of Internal Medicine Specialties & Department of Pathology-Immunology, University Hospitals of Geneva and University of Geneva, Geneva, Switzerland.

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January 2018

The perioperative use of synthetic and biological disease-modifying antirheumatic drugs in patients with rheumatoid arthritis.

Swiss Med Wkly 2017 11;147:w14563. Epub 2017 Dec 11.

Service de Rhumatologie, Département des Spécialités de Médecine, Hôpitaux Universitaires de Genève, Switzerland.

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September 2018

Salt-inducible kinases (SIK) inhibition reduces RANKL-induced osteoclastogenesis.

PLoS One 2017 3;12(10):e0185426. Epub 2017 Oct 3.

Division of Rheumatology, Department of Internal Medicine Specialties, University Hospitals of Geneva, Geneva, Switzerland.

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October 2017

[Adverse events of biologic therapies].

Rev Med Suisse 2017 Mar;13(553):542-548

Service de rhumatologie, Département des spécialités de médecine, HUG, Avenue de Beau-Séjour 26, 1206 Genève.

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March 2017

Complications iatrogènes : ce que tout médecin doit connaître.

Rev Med Suisse 2017 Mar;13(553):539-540

Service de rhumatologie, CHUV, Lausanne.

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March 2017

Rheumatoid arthritis: from basic findings and clinical manifestations to future therapies.

Semin Immunopathol 2017 06 21;39(4):339-341. Epub 2017 Jun 21.

Division of Rheumatology, University Hospital of Geneva, Geneva, Switzerland.

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June 2017

Reply.

J Allergy Clin Immunol 2017 07 29;140(1):316-317. Epub 2017 Apr 29.

Children's Hospital of Philadelphia, Philadelphia, Pa.

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July 2017

Cardiovascular risk in patients with rheumatoid arthritis.

Semin Immunopathol 2017 06 28;39(4):447-459. Epub 2017 Apr 28.

Division of Rheumatology, University Hospitals of Geneva, 26 Avenue Beau-Séjour, 1206, Geneva, Switzerland.

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June 2017

Presence of IL-17 in synovial fluid identifies a potential inflammatory osteoarthritic phenotype.

PLoS One 2017 11;12(4):e0175109. Epub 2017 Apr 11.

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom.

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September 2017

Rituximab Retreatment in Rheumatoid Arthritis in a Real-life Cohort: Data from the CERERRA Collaboration.

J Rheumatol 2017 02 15;44(2):162-169. Epub 2017 Jan 15.

From the Karolinska Institute, Department of Medicine, Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID), Stockholm, Sweden; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; ARBITER, Institute of Rheumatology, Moscow, Russia; DANBIO, Center for Rheumatology and Spine Diseases, Centre of Head and Orthopaedics, Rigshospitalet, Glostrup; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen; Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark; Institute of Rheumatology, Prague, Czech Republic; Swiss Clinical Quality Management (SCQM) Registry, University Hospital of Geneva, Geneva; SCQM Foundation, Zurich, Switzerland; National Register for Biologic Treatment in Finland (ROB-FIN), Helsinki University Central Hospital, Helsinki, Finland; Reuma.pt Registry, Instituto de Medicina Molecular da Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal; BioRx.si University Medical Centre, Ljubljana, Ljubljana, Slovenia; Rheumatology Department, Hospital Clinic of Barcelona, Barcelona; Hospital Clinico Universidad De Santiago, Santiago, Spain; Cantacuzino Hospital, Bucharest, Romania.

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February 2017

The role of female hormonal factors in the development of rheumatoid arthritis.

Rheumatology (Oxford) 2017 08;56(8):1254-1263

3Division of Rheumatology, Department of Internal Medicine Specialties.

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August 2017

Elevated serum levels of free interleukin-18 in adult-onset Still's disease.

Rheumatology (Oxford) 2016 Dec 10;55(12):2237-2247. Epub 2016 Sep 10.

Division of Rheumatology, Department of Internal Medicine Specialties, University Hospitals of Geneva, Geneva, Switzerland,

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December 2016

IL-36-Induced Toxicity in Neonatal Mice Involves TNF-α Production by Liver Myeloid Cells.

J Immunol 2016 09 15;197(6):2239-49. Epub 2016 Aug 15.

Division of Rheumatology, Department of Internal Medicine Specialties, University Hospitals of Geneva, 1211 Geneva 4, Switzerland; Department of Pathology-Immunology, University of Geneva, School of Medicine, 1211 Geneva 4, Switzerland;

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September 2016

Interleukin-36 potently stimulates human M2 macrophages, Langerhans cells and keratinocytes to produce pro-inflammatory cytokines.

Cytokine 2016 08 31;84:88-98. Epub 2016 May 31.

Department of Pathology and Immunology, University of Geneva, School of Medicine, Geneva, Switzerland; Division of Rheumatology, University Hospital Geneva, Switzerland. Electronic address:

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August 2016

[Spondylarthropathies in 2015].

Rev Med Suisse 2016 Mar;12(509):483

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March 2016

Effect of particle size on the biodistribution of nano- and microparticles following intra-articular injection in mice.

Int J Pharm 2016 Feb 10;498(1-2):119-29. Epub 2015 Dec 10.

School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Geneva, Switzerland. Electronic address:

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February 2016

SIK inhibition in human myeloid cells modulates TLR and IL-1R signaling and induces an anti-inflammatory phenotype.

J Leukoc Biol 2016 05 20;99(5):711-21. Epub 2015 Nov 20.

Division of Rheumatology, Department of Internal Medicine Specialties, University Hospitals of Geneva, and Department of Pathology and Immunology, University of Geneva School of Medicine, Geneva, Switzerland

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May 2016

Atherosclerosis severity is not affected by a deficiency in IL-33/ST2 signaling.

Immun Inflamm Dis 2015 Sep 10;3(3):239-46. Epub 2015 May 10.

Division of Rheumatology, University Hospital of Geneva Geneva, Switzerland ; Department of Pathology and Immunology School of Medicine, University of Geneva Geneva, Switzerland.

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September 2015

Inflammatory Articular Disease in Patients with Inflammatory Bowel Disease: Result of the Swiss IBD Cohort Study.

Inflamm Bowel Dis 2015 Nov;21(11):2598-604

*Clinique La Colline and Division of Gastroenterology and Hepatology, University Hospital of Geneva, Geneva, Switzerland; †Institute of Social and Preventive Medicine (IUMSP), Lausanne University Hospital, Lausanne, Switzerland; ‡Division of Gastroenterology, Clinic for Visceral Surgery and Medicine, Bern University Hospital, Bern, Switzerland; §Gastroenterology La Source-Beaulieu and Division of Gastroenterology and Hepatology, CHUV, Lausanne, Switzerland; and ‖Division of Rheumatology, University Hospital of Geneva, Geneva, Switzerland.

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November 2015

The interleukin (IL)-1 cytokine family--Balance between agonists and antagonists in inflammatory diseases.

Cytokine 2015 Nov 13;76(1):25-37. Epub 2015 Jul 13.

Division of Rheumatology, Departments of Internal Medicine Specialties and of Pathology-Immunology, University of Geneva School of Medicine, Switzerland. Electronic address:

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November 2015

Pneumococcal polysaccharide vaccination in adults undergoing immunosuppressive treatment for inflammatory diseases--a longitudinal study.

Arthritis Res Ther 2015 Jun 6;17:151. Epub 2015 Jun 6.

Division of Clinical Immunology and Allergy, Department of Medical Specialties, University Hospital and Faculty of Medicine, Geneva, Switzerland.

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June 2015

Limited Contribution of IL-36 versus IL-1 and TNF Pathways in Host Response to Mycobacterial Infection.

PLoS One 2015 7;10(5):e0126058. Epub 2015 May 7.

Division of Rheumatology, Department of Internal Medicine Specialties, University Hospitals of Geneva, Geneva, Switzerland; Department of Pathology and Immunology, University of Geneva Medical School, Geneva, Switzerland.

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April 2016

Effectiveness of biologic DMARDs in monotherapy versus in combination with synthetic DMARDs in rheumatoid arthritis: data from the Swiss Clinical Quality Management Registry.

Rheumatology (Oxford) 2015 Sep 27;54(9):1664-72. Epub 2015 Apr 27.

Division of Rheumatology, Department of Medical Specialties, University Hospitals of Geneva.

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September 2015

Intra-articular bioactivity of a p38 MAPK inhibitor and development of an extended-release system.

Eur J Pharm Biopharm 2015 Jun 30;93:110-7. Epub 2015 Mar 30.

School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Geneva, Switzerland. Electronic address:

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June 2015

Regulation and function of interleukin-36 cytokines in homeostasis and pathological conditions.

J Leukoc Biol 2015 Apr 11;97(4):645-52. Epub 2015 Feb 11.

*Division of Rheumatology, Departments of Internal Medicine Specialties and Pathology-Immunology, University Hospitals of Geneva and University of Geneva, Switzerland; and Department of Inflammation Research, Amgen, Seattle, Washington, USA

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April 2015

Severe neutrophil-dominated inflammation and enhanced myelopoiesis in IL-33-overexpressing CMV/IL33 mice.

J Immunol 2015 Jan 10;194(2):750-60. Epub 2014 Dec 10.

Division of Rheumatology, Department of Internal Medicine Specialties, University Hospital, 1211 Geneva 4, Switzerland; Department of Pathology-Immunology, University of Geneva School of Medicine, 1211 Geneva 4, Switzerland;

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January 2015

Inflammation: IL-36 has proinflammatory effects in skin but not in joints.

Nat Rev Rheumatol 2014 Nov 9;10(11):639-40. Epub 2014 Sep 9.

Division of Rheumatology, University Hospitals of Geneva, 26 Avenue de Beau-Séjour, 1211 Geneva 14, Switzerland.

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November 2014

Joint damage progression in patients with rheumatoid arthritis in clinical remission: do biologics perform better than synthetic antirheumatic drugs?

J Rheumatol 2014 Aug 15;41(8):1576-82. Epub 2014 Jul 15.

From the Division of Rheumatology, University Hospital Sacré Coeur de Montréal, Montréal, Canada; Division of Rheumatology, University Hospital of Geneva; and Division of Clinical Epidemiology, University Hospital of Geneva, Geneva, Switzerland.E. Ciubotariu, MD, MSc, Division of Rheumatology, University Hospital Sacré Coeur of Montréal; C. Gabay, MD, PhD, Professor, Division of Rheumatology, University Hospital of Geneva; A. Finckh, MD, PhD, Adjoint Professor Division of Rheumatology; Division of Clinical Epidemiology, University Hospital of Geneva.

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August 2014

Immune-mediated experimental arthritis in IL-33 deficient mice.

Cytokine 2014 Sep 11;69(1):68-74. Epub 2014 Jun 11.

Division of Rheumatology, Department of Internal Medicine, University Hospital, Geneva, Switzerland; Department of Pathology and Immunology, University of Geneva School of Medicine, Geneva, Switzerland. Electronic address:

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September 2014

Adipokines correlate with pain in lower limb osteoarthritis: different associations in hip and knee.

Int Orthop 2014 Dec 9;38(12):2577-83. Epub 2014 Jul 9.

Division of Rheumatology, Geneva University Hospitals and University of Geneva, Geneva, Switzerland.

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December 2014

The advent of biosimilars: challenges and risks.

Swiss Med Wkly 2014 1;144:w13980. Epub 2014 Jul 1.

Kantonsspital Aarau, Aarau, Switzerland.

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February 2015

In Black Africans with rheumatoid arthritis, ACPA recognize citrullinated fibrinogen and the derived peptides α36-50Cit38,42 and β60-74Cit60,72,74, like in Caucasians.

Clin Immunol 2014 May-Jun;152(1-2):58-64. Epub 2014 Mar 1.

"Epidermis Differentiation and Rheumatoid Autoimmunity" Laboratory, UMR CNRS 5165, INSERM U1056, Toulouse III University, Toulouse, France; Laboratory of Cell Biology and Cytology, Toulouse University Hospital, Toulouse, France.

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July 2014