Cees J Tack

Cees J Tack

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Cees J Tack

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Long-term efficacy and safety of combined insulin and glucagon-like peptide-1 therapy: Evidence from the LEADER trial.

Diabetes Obes Metab 2019 Nov 7;21(11):2450-2458. Epub 2019 Jul 7.

Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1111/dom.13826DOI Listing
November 2019

Sixteen-Week Physical Activity Intervention in Subjects With Increased Cardiometabolic Risk Shifts Innate Immune Function Towards a Less Proinflammatory State.

J Am Heart Assoc 2019 Nov 18;8(21):e013764. Epub 2019 Oct 18.

Department of Internal Medicine Radboud Institute for Molecular Life Sciences (RIMLS) Radboud University Medical Center Nijmegen The Netherlands.

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http://dx.doi.org/10.1161/JAHA.119.013764DOI Listing
November 2019

RT-CGM in adults with type 1 diabetes improves both glycaemic and patient-reported outcomes, but independent of each other.

Diabetes Res Clin Pract 2019 Oct 31:107910. Epub 2019 Oct 31.

Radboud university medical center, Department of Internal Medicine, 463, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.diabres.2019.107910DOI Listing
October 2019

Evaluation of chitotriosidase as a biomarker for adipose tissue inflammation in overweight individuals and type 2 diabetic patients.

Int J Obes (Lond) 2019 Sep 9;43(9):1712-1723. Epub 2018 Oct 9.

Translational Metabolic Laboratory, Department of Laboratory Medicine, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://www.nature.com/articles/s41366-018-0225-8
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http://dx.doi.org/10.1038/s41366-018-0225-8DOI Listing
September 2019

Oral Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes.

N Engl J Med 2019 08 11;381(9):841-851. Epub 2019 Jun 11.

From the Peter Munk Cardiac Centre, University Health Network, Department of Medicine and the Heart and Stroke Richard Lewar Centre, University of Toronto, Toronto General Hospital Research Institute, and the Ted Rogers Centre for Heart Research, Toronto (M.H.), and the C-endo Diabetes and Endocrinology Clinic, Calgary, AB (S.D.P.) - all in Canada; Medical Clinic III, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden, and the Paul Langerhans Institute Dresden of Helmholtz Zentrum München at Technische Universität Dresden, German Center for Diabetes Research, Dresden, Germany (A.L.B.); the Division of Diabetes and Nutritional Sciences, Rayne Institute, King's College London, London (A.L.B.), and the Diabetes Research Unit Cymru, Swansea University Medical School, Swansea (S.C.B.) - both in the United Kingdom; Novo Nordisk, Søborg, Denmark (M.D., O.K.J., M.T.); the Division of Endocrinology, Diabetes, and Metabolism, Ohio State University, Columbus (K.D.); Centro de Pesquisas Clínicas/Diagnosticos da America Clinical Research Center, São Paulo (F.G.E., D.R.F.); the Departments of Internal Medicine and Population and Data Sciences, University of Texas Southwestern Medical Center, Dallas (I.L.); the Diabetes Unit, Division of Internal Medicine, Hadassah Hebrew University Hospital, Jerusalem (O.M.); the Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands (C.J.T); Clinical Metabolic Physiology, Steno Diabetes Center Copenhagen, University of Copenhagen, Gentofte, Denmark (T.V.); and Physicians East, Greenville, NC (M.L.W.).

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http://dx.doi.org/10.1056/NEJMoa1901118DOI Listing
August 2019

RETINAL HYPERREFLECTIVE FOCI IN TYPE 1 DIABETES MELLITUS.

Retina 2019 Jul 25. Epub 2019 Jul 25.

Department of Ophthalmology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands.

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http://dx.doi.org/10.1097/IAE.0000000000002626DOI Listing
July 2019

Renal phospholipidosis and impaired magnesium handling in high-fat-diet-fed mice.

FASEB J 2019 Jun 8;33(6):7192-7201. Epub 2019 Mar 8.

Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1096/fj.201801778RRDOI Listing
June 2019

Effect of the GLP-1 receptor agonist exenatide on impaired awareness of hypoglycemia in type 1 diabetes; a randomized controlled trial.

J Clin Endocrinol Metab 2019 Apr 8. Epub 2019 Apr 8.

Department of Internal Medicine, Radboud university medical center, Nijmegen, the Netherlands.

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http://dx.doi.org/10.1210/jc.2019-00087DOI Listing
April 2019

Validation of a model for the prediction of retinopathy in persons with type 1 diabetes.

Br J Ophthalmol 2019 Mar 1. Epub 2019 Mar 1.

Department of General Practice and Elderly Care Medicine, Amsterdam Public Health Research Institute, VU Medical Centre, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1136/bjophthalmol-2018-313539DOI Listing
March 2019

The future of protein biomarker research in type 2 diabetes mellitus.

Expert Rev Proteomics 2019 02 27;16(2):105-115. Epub 2018 Nov 27.

a Translational Metabolic Laboratory, Department of Laboratory Medicine and Radboud Institute for Molecular Life Sciences , Radboud University Medical Center , Nijmegen , The Netherlands.

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http://dx.doi.org/10.1080/14789450.2018.1551134DOI Listing
February 2019

High-Dose, Diazoxide-Mediated Insulin Suppression Boosts Weight Loss Induced by Lifestyle Intervention.

J Clin Endocrinol Metab 2018 11;103(11):4014-4022

Department of Internal Medicine, Rijnstate Hospital, AD Arnhem, Netherlands.

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http://dx.doi.org/10.1210/jc.2018-01147DOI Listing
November 2018

Hypoglycaemia induces recruitment of non-classical monocytes and cytotoxic lymphocyte subsets in type 1 diabetes.

Diabetologia 2018 09 7;61(9):2069-2071. Epub 2018 Jul 7.

Department of Internal Medicine, Radboud University Medical Center, PO Box 9101, 6500 HB, Nijmegen, the Netherlands.

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http://dx.doi.org/10.1007/s00125-018-4683-2DOI Listing
September 2018

Magnesium deficiency prevents high-fat-diet-induced obesity in mice.

Diabetologia 2018 09 9;61(9):2030-2042. Epub 2018 Jul 9.

Department of Physiology (286), Radboud Institute for Molecular Life Sciences, Radboud university medical center, P. O. Box 9101, 6500 HB, Nijmegen, the Netherlands.

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http://dx.doi.org/10.1007/s00125-018-4680-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096631PMC
September 2018

Risk factors for development and progression of diabetic retinopathy in Dutch patients with type 1 diabetes mellitus.

Acta Ophthalmol 2018 Aug;96(5):459-464

Department of Ophthalmology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1111/aos.13815DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174939PMC
August 2018

Environmental Signals Influencing Myeloid Cell Metabolism and Function in Diabetes.

Trends Endocrinol Metab 2018 07 19;29(7):468-480. Epub 2018 May 19.

Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands; Nutrition, Metabolism and Genomics Group, Division of Human Nutrition and Health, Wageningen University, Wageningen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.tem.2018.04.008DOI Listing
July 2018

Effect of Automated Bolus Calculation on Glucose Variability and Quality of Life in Patients With Type 1 Diabetes on CSII Treatment.

Clin Ther 2018 06 1;40(6):862-871. Epub 2018 Mar 1.

Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.

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http://dx.doi.org/10.1016/j.clinthera.2018.02.004DOI Listing
June 2018

Effects of Diazoxide-Mediated Insulin Suppression on Glucose and Lipid Metabolism in Nondiabetic Obese Men.

J Clin Endocrinol Metab 2018 06;103(6):2346-2353

Department of Internal Medicine, Rijnstate Hospital, Arnhem, The Netherlands.

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http://dx.doi.org/10.1210/jc.2018-00161DOI Listing
June 2018

Is fatigue a disease-specific or generic symptom in chronic medical conditions?

Health Psychol 2018 06;37(6):530-543

Expert Center for Chronic Fatigue, Department of Medical Psychology, Amsterdam Public Health Research Institute, VU University Medical Center.

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http://dx.doi.org/10.1037/hea0000598DOI Listing
June 2018

IL-1 Family Cytokine Pathways Underlying NAFLD: Towards New Treatment Strategies.

Trends Mol Med 2018 05 14;24(5):458-471. Epub 2018 Apr 14.

Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands; R&D Department, Hycult Biotech, Uden, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.molmed.2018.03.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5939989PMC
May 2018

Effect of Exercise-Induced Lactate Elevation on Brain Lactate Levels During Hypoglycemia in Patients With Type 1 Diabetes and Impaired Awareness of Hypoglycemia.

Diabetes 2017 12 21;66(12):3105-3110. Epub 2017 Sep 21.

Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.

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http://dx.doi.org/10.2337/db17-0794DOI Listing
December 2017

Metformin and daclatasvir: absence of a pharmacokinetic-pharmacodynamic drug interaction in healthy volunteers.

Br J Clin Pharmacol 2017 Oct 6;83(10):2225-2234. Epub 2017 Jun 6.

Department of Pharmacy and Radboud Institute for Health Sciences (RIHS), Radboud university medical center, Nijmegen, the Netherlands.

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http://dx.doi.org/10.1111/bcp.13323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595943PMC
October 2017

Pharmacokinetic and Pharmacodynamic Variability of Insulin When Administered by Jet Injection.

J Diabetes Sci Technol 2017 09 17;11(5):947-952. Epub 2017 Mar 17.

1 Department of Internal Medicine, Radboud University Medical Center, Nijmegen, Netherlands.

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http://dx.doi.org/10.1177/1932296817699638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5950987PMC
September 2017

Genetic determinants of impaired awareness of hypoglycemia in type 1 diabetes.

Pharmacogenet Genomics 2017 Sep;27(9):323-328

Departments of aPharmacology and Toxicology bInternal Medicine cHuman Genetics, Radboud University Medical Center, Nijmegen, The Netherlands dGenetics and Genome Biology Program, The Hospital for Sick Children, Peter Gilgan Centre for Research and Learning, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/FPC.0000000000000295DOI Listing
September 2017

Insulin-Associated Weight Gain in Type 2 Diabetes Is Associated With Increases in Sedentary Behavior.

Diabetes Care 2017 09 10;40(9):e120-e121. Epub 2017 Jul 10.

Radboud Institute for Health Sciences, Department of Physiology, Radboud University Medical Center, Nijmegen, the Netherlands

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http://dx.doi.org/10.2337/dc17-0787DOI Listing
September 2017

A Single Bout of High-Intensity Interval Training Reduces Awareness of Subsequent Hypoglycemia in Patients With Type 1 Diabetes.

Diabetes 2017 07 18;66(7):1990-1998. Epub 2017 Apr 18.

Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.

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http://dx.doi.org/10.2337/db16-1535DOI Listing
July 2017

Reactive Rather than Proactive Diabetes Management in the Perioperative Period.

Horm Metab Res 2017 Jul 24;49(7):527-533. Epub 2017 Apr 24.

Department of General Internal Medicine, Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1055/s-0043-105501DOI Listing
July 2017

Web-based cognitive behavioural therapy blended with face-to-face sessions for chronic fatigue in type 1 diabetes: a multicentre randomised controlled trial.

Lancet Diabetes Endocrinol 2017 06 24;5(6):448-456. Epub 2017 Apr 24.

Expert Centre for Chronic Fatigue, Department of Medical Psychology, Amsterdam Public Health Research Institute, VU University Medical Center, Amsterdam, Netherlands; Academic Medical Center, University of Amsterdam, Department of Medical Psychology, Amsterdam Public Health Research Institute, Amsterdam, Netherlands. Electronic address:

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http://dx.doi.org/10.1016/S2213-8587(17)30098-0DOI Listing
June 2017

Proinflammatory Effects of Hypoglycemia in Humans With or Without Diabetes.

Diabetes 2017 04 23;66(4):1052-1061. Epub 2017 Jan 23.

Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.

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http://dx.doi.org/10.2337/db16-1091DOI Listing
April 2017

Corrigendum to "Severe fatigue in type 1 diabetes: Exploring its course, predictors and relationship with HbA in a prospective study" [Diabetes Res. Clin. Pract. 121 (2016) 127-134].

Diabetes Res Clin Pract 2017 04 27;126:325. Epub 2017 Feb 27.

Expert Center for Chronic Fatigue, Radboud University Medical Center, Nijmegen, The Netherlands; Department of Medical Psychology, Academic Medical Centre (AMC), University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.diabres.2017.02.018DOI Listing
April 2017

Prevalence and correlates of pain in fatigued patients with type 1 diabetes.

J Psychosom Res 2017 04 21;95:68-73. Epub 2017 Feb 21.

Expert Center for Chronic Fatigue, Department of Medical Psychology, Amsterdam Public Health Research Institute, VU University Medical Center, P.O. Box 22660, 1100 DD, Amsterdam, The Netherlands; Academic Medical Center (AMC), University of Amsterdam, Department of Medical Psychology, Amsterdam Public Health Research Institute, P.O. Box 22660, 1100 DD, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.jpsychores.2017.02.010DOI Listing
April 2017

Determinants of hypomagnesemia in patients with type 2 diabetes mellitus.

Eur J Endocrinol 2017 Jan 5;176(1):11-19. Epub 2016 Oct 5.

Departments of Physiology

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http://dx.doi.org/10.1530/EJE-16-0517DOI Listing
January 2017

Diabetes propels the risk for cardiovascular disease: sweet monocytes becoming aggressive?

Cell Mol Life Sci 2016 12 28;73(24):4675-4684. Epub 2016 Jul 28.

Department of Internal Medicine, Radboud Institute for Molecular Life Sciences, Radboud University Nijmegen Medical Center, Radboudumc, (463), P. O. Box 9101, 6500 HB, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1007/s00018-016-2316-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5097107PMC
December 2016

Severe fatigue in type 1 diabetes: Exploring its course, predictors and relationship with HbA in a prospective study.

Diabetes Res Clin Pract 2016 11 21;121:127-134. Epub 2016 Sep 21.

Expert Center for Chronic Fatigue, Radboud University Medical Center, Nijmegen, The Netherlands; Department of Medical Psychology, Academic Medical Centre (AMC), University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.diabres.2016.09.011DOI Listing
November 2016

Major gaps between recommended perioperative diabetes care and current practice.

Eur J Intern Med 2016 Oct 21;34:e11-e13. Epub 2016 Jun 21.

Scientific Institute for Quality of Healthcare, Radboud Institute for Health Sciences, Radboud University Medical Center, PO Box 9101, Post 114, 6500 HB, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.ejim.2016.06.008DOI Listing
October 2016

Enterovirus Exposure Uniquely Discriminates Type 1 Diabetes Patients with a Homozygous from a Heterozygous Melanoma Differentiation-Associated Protein 5/Interferon Induced with Helicase C Domain 1 A946T Genotype.

Viral Immunol 2016 09 2;29(7):389-97. Epub 2016 Aug 2.

1 Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center , Nijmegen, the Netherlands .

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http://dx.doi.org/10.1089/vim.2015.0140DOI Listing
September 2016

Perioperative diabetes care: development and validation of quality indicators throughout the entire hospital care pathway.

BMJ Qual Saf 2016 07 17;25(7):525-34. Epub 2015 Sep 17.

Radboud University Medical Center, Radboud Institute for Health Sciences, Scientific Institute for Quality of Healthcare, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1136/bmjqs-2015-004112DOI Listing
July 2016

The placebo response of injectable GLP-1 receptor agonists vs. oral DPP-4 inhibitors and SGLT-2 inhibitors: a systematic review and meta-analysis.

Br J Clin Pharmacol 2016 07 22;82(1):301-14. Epub 2016 Apr 22.

Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.

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http://dx.doi.org/10.1111/bcp.12925DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917794PMC
July 2016

Brain Lactate Concentration Falls in Response to Hypoglycemia in Patients With Type 1 Diabetes and Impaired Awareness of Hypoglycemia.

Diabetes 2016 06 18;65(6):1601-5. Epub 2016 Mar 18.

Department of Radiology and Nuclear Medicine, Radboud university medical center, Nijmegen, the Netherlands Department of Pediatrics, Radboud university medical center, Nijmegen, the Netherlands.

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http://dx.doi.org/10.2337/db16-0068DOI Listing
June 2016

Salvia Miltiorrhiza Root Water-Extract (Danshen) Has No Beneficial Effect on Cardiovascular Risk Factors. A Randomized Double-Blind Cross-Over Trial.

PLoS One 2015 20;10(7):e0128695. Epub 2015 Jul 20.

Department of Internal Medicine, Radboud university medical center, Nijmegen, The Netherlands; Department of Pharmacology and Toxicology, Radboud university medical center, Nijmegen, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0128695PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508048PMC
April 2016

TLR-3 is present in human adipocytes, but its signalling is not required for obesity-induced inflammation in adipose tissue in vivo.

PLoS One 2015 13;10(4):e0123152. Epub 2015 Apr 13.

Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands; Department of Human Nutrition, Wageningen University and Research Centre, Wageningen, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0123152PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4395029PMC
March 2016

Genetic and pharmacological inhibition of vanin-1 activity in animal models of type 2 diabetes.

Sci Rep 2016 Mar 2;6:21906. Epub 2016 Mar 2.

Department of Internal Medicine, Radboud University Nijmegen Medical Centre, 6525 GA Nijmegen, The Netherlands.

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http://dx.doi.org/10.1038/srep21906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773925PMC
March 2016

Brain glucose metabolism during hypoglycemia in type 1 diabetes: insights from functional and metabolic neuroimaging studies.

Cell Mol Life Sci 2016 Feb 31;73(4):705-22. Epub 2015 Oct 31.

Department of Internal Medicine 463, Radboud University Medical Center, PO Box 9101, 6500 HB, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1007/s00018-015-2079-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735263PMC
February 2016

One week treatment with the IL-1 receptor antagonist anakinra leads to a sustained improvement in insulin sensitivity in insulin resistant patients with type 1 diabetes mellitus.

Clin Immunol 2015 Oct 11;160(2):155-62. Epub 2015 Jun 11.

Department of Internal Medicine, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.clim.2015.06.003DOI Listing
October 2015

IL-1 family members in the pathogenesis and treatment of metabolic disease: Focus on adipose tissue inflammation and insulin resistance.

Cytokine 2015 Oct 17;75(2):280-90. Epub 2015 Jul 17.

Department of Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.cyto.2015.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4553099PMC
October 2015

[Sulphonylurea derivatives or insulin with metformin?].

Ned Tijdschr Geneeskd 2014 ;158:A8239

Radboudumc, Nijmegen.

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April 2015

MAP3K8 (TPL2/COT) affects obesity-induced adipose tissue inflammation without systemic effects in humans and in mice.

PLoS One 2014 24;9(2):e89615. Epub 2014 Feb 24.

Department of Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands ; Institute for Genomic and Metabolic Disease, Radboud University Medical Centre, Nijmegen, The Netherlands ; Department of Human Nutrition, Wageningen University and Research Centre, Wageningen, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0089615PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3933658PMC
March 2015

Diabetes-related distress, insulin dose, and age contribute to insulin-associated weight gain in patients with type 2 diabetes: results of a prospective study.

Diabetes Care 2014 Oct 10;37(10):2710-7. Epub 2014 Jul 10.

Department of Internal Medicine, Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands.

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http://dx.doi.org/10.2337/dc13-1205DOI Listing
October 2014

Liraglutide reverses pronounced insulin-associated weight gain, improves glycaemic control and decreases insulin dose in patients with type 2 diabetes: a 26 week, randomised clinical trial (ELEGANT).

Diabetologia 2014 Sep 20;57(9):1812-9. Epub 2014 Jun 20.

Department of Internal Medicine 463, Section Diabetes, Radboud University Medical Centre, PO Box 9101, 6500 HB, Nijmegen, the Netherlands,

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http://dx.doi.org/10.1007/s00125-014-3302-0DOI Listing
September 2014

IL-37 protects against obesity-induced inflammation and insulin resistance.

Nat Commun 2014 Sep 3;5:4711. Epub 2014 Sep 3.

1] Department of Medicine, Radboud University Medical Centre, Geert Grooteplein 8, P.O. Box 9101, Nijmegen 6500 HB, The Netherlands [2] Department of Human Nutrition, Wageningen University, Wageningen 6703 HD, The Netherlands.

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http://link.springer.com/content/pdf/10.1007%2Fs12467-012-01
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http://www.nature.com/doifinder/10.1038/ncomms5711
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http://dx.doi.org/10.1038/ncomms5711DOI Listing
September 2014

PPAR-alpha dependent regulation of vanin-1 mediates hepatic lipid metabolism.

J Hepatol 2014 Aug 18;61(2):366-72. Epub 2014 Apr 18.

Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands; Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands.

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http://dx.doi.org/10.1016/j.jhep.2014.04.013DOI Listing
August 2014

Physical activity at altitude: challenges for people with diabetes: a review.

Diabetes Care 2014 Aug;37(8):2404-13

Department of Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands.

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http://dx.doi.org/10.2337/dc13-2302DOI Listing
August 2014

Dietary lipids do not contribute to the higher hepatic triglyceride levels of fructose- compared to glucose-fed mice.

FASEB J 2014 May 5;28(5):1988-97. Epub 2014 Feb 5.

1Department of Physiology and Metabolism, National Institute for Medical Research, the Ridgeway, Mill Hill, NW7 1AA, London, UK.

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http://www.fasebj.org/doi/10.1096/fj.13-241208
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http://dx.doi.org/10.1096/fj.13-241208DOI Listing
May 2014

Life-long physical activity restores metabolic and cardiovascular function in type 2 diabetes.

Eur J Appl Physiol 2014 Mar 20;114(3):619-27. Epub 2013 Dec 20.

Department of Physiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands,

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http://dx.doi.org/10.1007/s00421-013-2794-5DOI Listing
March 2014

Liver fat content is linked to inflammatory changes in subcutaneous adipose tissue in type 2 diabetes patients.

Clin Endocrinol (Oxf) 2013 Nov 19;79(5):661-6. Epub 2013 Apr 19.

Department of Internal Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.

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http://doi.wiley.com/10.1111/cen.12105
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http://dx.doi.org/10.1111/cen.12105DOI Listing
November 2013

Upregulation of skeletal muscle inflammatory genes links inflammation with insulin resistance in women with the metabolic syndrome.

Exp Physiol 2013 Oct 14;98(10):1485-94. Epub 2013 Jun 14.

M. T. E. Hopman: Radboud University Nijmegen Medical Centre, Department of Physiology (392), PO Box 9101, 6500 HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.1113/expphysiol.2013.072710DOI Listing
October 2013

A novel insulin combination of insulin degludec and insulin aspart achieves a more stable overnight glucose profile than insulin glargine: results from continuous glucose monitoring in a proof-of-concept trial.

J Diabetes Sci Technol 2013 Sep 1;7(5):1328-36. Epub 2013 Sep 1.

Department for Internal Medicine, Center for Diabetes and Metabolism, Fachklinik Bad Heilbrunn, Woernerweg 30, D-83670 Bad Heilbrunn, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876378PMC
http://dx.doi.org/10.1177/193229681300700524DOI Listing
September 2013

Combined B- and T-cell deficiency does not protect against obesity-induced glucose intolerance and inflammation.

Cytokine 2013 Apr 9;62(1):96-103. Epub 2013 Mar 9.

Department of General Internal Medicine, Radboud University Medical Centre, Nijmegen Institute of Inflammation Immunity and Infection (N4i), Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.cyto.2013.02.009DOI Listing
April 2013

Patients with type 1 diabetes exhibit altered cerebral metabolism during hypoglycemia.

J Clin Invest 2013 Feb 9;123(2):623-9. Epub 2013 Jan 9.

Department of Radiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1172/JCI62742DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561817PMC
February 2013

Metabolic effects of high altitude trekking in patients with type 2 diabetes.

Diabetes Care 2012 Oct 24;35(10):2018-20. Epub 2012 Jul 24.

Department of Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.2337/dc12-0204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447827PMC
October 2012

Inflammation links excess fat to insulin resistance: the role of the interleukin-1 family.

Immunol Rev 2012 Sep;249(1):239-52

Department of Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://doi.wiley.com/10.1111/j.1600-065X.2012.01145.x
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http://dx.doi.org/10.1111/j.1600-065X.2012.01145.xDOI Listing
September 2012

Steady-state brain glucose concentrations during hypoglycemia in healthy humans and patients with type 1 diabetes.

Diabetes 2012 Aug 11;61(8):1974-7. Epub 2012 Jun 11.

Department of Radiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.2337/db11-1778DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402320PMC
August 2012

The inflammasome puts obesity in the danger zone.

Cell Metab 2012 Jan;15(1):10-8

Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen 6525 GA, The Netherlands.

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http://dx.doi.org/10.1016/j.cmet.2011.10.011DOI Listing
January 2012

The inflammasome and caspase-1 activation: a new mechanism underlying increased inflammatory activity in human visceral adipose tissue.

Endocrinology 2011 Oct 23;152(10):3769-78. Epub 2011 Aug 23.

Department of General Internal Medicine, Radboud University Nijmegen Medical Centre, Internal Postal Code 463, Geert Grooteplein 8, 6500 HB Nijmegen, The Netherlands.

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https://academic.oup.com/endo/article-lookup/doi/10.1210/en.
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http://dx.doi.org/10.1210/en.2010-1480DOI Listing
October 2011

Vildagliptin improves endothelium-dependent vasodilatation in type 2 diabetes.

Diabetes Care 2011 Sep 25;34(9):2072-7. Epub 2011 Jul 25.

Department of Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands.

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http://dx.doi.org/10.2337/dc10-2421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3161271PMC
September 2011

Inflammasome is a central player in the induction of obesity and insulin resistance.

Proc Natl Acad Sci U S A 2011 Sep 29;108(37):15324-9. Epub 2011 Aug 29.

Department of Medicine, Radboud University Nijmegen Medical Centre, and Nijmegen Institute for Infection, Inflammation and Immunity, 6525 GA Nijmegen, The Netherlands.

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http://dx.doi.org/10.1073/pnas.1100255108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174591PMC
September 2011

Improved pharmacokinetic and pharmacodynamic profile of rapid-acting insulin using needle-free jet injection technology.

Diabetes Care 2011 Aug 29;34(8):1804-8. Epub 2011 Jun 29.

Department of Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands.

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http://dx.doi.org/10.2337/dc11-0182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142054PMC
August 2011

Treatment with Anakinra improves disposition index but not insulin sensitivity in nondiabetic subjects with the metabolic syndrome: a randomized, double-blind, placebo-controlled study.

J Clin Endocrinol Metab 2011 Jul 20;96(7):2119-26. Epub 2011 Apr 20.

Department of Internal Medicine, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.1210/jc.2010-2992DOI Listing
July 2011

Increased insulin requirements during exercise at very high altitude in type 1 diabetes.

Diabetes Care 2011 Mar 27;34(3):591-5. Epub 2011 Jan 27.

Department of Internal Medicine, Canisius Wilhelmina Hospital, Nijmegen, the Netherlands.

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http://care.diabetesjournals.org/cgi/doi/10.2337/dc10-2015
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http://dx.doi.org/10.2337/dc10-2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3041186PMC
March 2011

Treating diabetes by improving cardiac output.

Eur J Heart Fail 2011 Feb;13(2):133-4

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http://dx.doi.org/10.1093/eurjhf/hfq235DOI Listing
February 2011