Carsten H. Meyer , MD, FEBO, FMH -  Aarau, Switzerland - Professor of Ophthalmology  Philipps University Marburg, Germany and Paulista Federal University of São Paulo, Brazil

Carsten H. Meyer

MD, FEBO, FMH

Aarau, Switzerland

Professor of Ophthalmology Philipps University Marburg, Germany and Paulista Federal University of São Paulo, Brazil

Aarau , Aargau | Switzerland

Main Specialties: Ophthalmology

Additional Specialties: Ophthalmology, Vitreo-retinal surgery, ocular pharmacokinetics

ORCID logohttps://orcid.org/0000-0002-0530-5298

Carsten H. Meyer , MD, FEBO, FMH -  Aarau, Switzerland - Professor of Ophthalmology  Philipps University Marburg, Germany and Paulista Federal University of São Paulo, Brazil

Carsten H. Meyer

MD, FEBO, FMH

Introduction

Carsten H. Meyer holds an M.D. degree and serves as a specialist in vitreoretinal diseases. He went to medical schools in Freiburg (Germanx), Innsbruck (Austria ), and Oxford (GB) and obtained his medical degree from the University of Munich, Munich, Germany. Dr. Meyer completed his Residency at the University Eye Hospital, Luebeck, Germany, and in 1999 pursued a 2-year vitreoretinal research Fellowship at the Duke Eye Center, Durham, NC, USA. He returned to Germany and became an Assistant Professor in the Department of Ophthalmology, Philipp-University, Marburg, Germany. He was appointed at the Department of Ophthalmology, University of Bonn, Germany, in 2006 and became Professor in 2007. His main research interests include imaging vitreoretinal structures, retinal bear tracks, chromovitrectomy, and novel treatments in age-related macular degeneration. Dr. Meyer is an editorial board member of several ophthalmic journals and serves as a reviewer in more than 55 peer-reviewed journals.
Dr. Meyer has published >40 book chapters, >240 articles in pubmed listed journals with a cumulative impact factor > and counts >6100 citations with a H-Index of 43, i10-Index 133. He received the AAO Achievement Award (2008); holds membership in the Retina Society, Club Jules Gonin, EURETINA, Deutsche Ophthalmologische Gesellschaft (DOG), Marquis Who's Who, ORBIS; and is a dedicated examiner in the panel of the European Board of Ophthalmology (EBO). Until 2018 he served as the Head of the Department of Ophthalmology, Pallas Clinic, Aarau , Switzerland and recieved in 2014 an appointment at the ESASO faculty Switzerland. Recently he became affiliated Professor of Ophthalmology at the Paulista Federal University of Sao Paulo (UNIFESP), Brazil.

Primary Affiliation: Aarau, Switzerland - Aarau , Aargau , Switzerland

Specialties:

Additional Specialties:

Research Interests:

Metrics

Number of Publications

305

Publications

Number of Profile Views

944

Profile Views

Number of Article Reads

2648

Reads

Number of Citations

901

Citations

Education

May 2017
Paulista, Federal University of Sao Paulo (UNIFESP), Brazil
affiliated Professor of Ophthalmology, appointed UNIFESP faculty
Nov 2014
Università della Svizzera italiana, Lugano, European School for Advanced Studies in Ophthalmology (ESASO)
ESASO faculty appointment
Apr 2012
King-Georg University, Lucknow, India (Professor Saxena)
Visiting Professor, Science and editing advisor
Mar 2011
Schweizerische Ophthalmologische Gesellschaft (SOG)
FMH-Facharzt für Ophthalmologie und Opthalmochirurgie
Feb 2011
Pallas Clinics, Aarau
Head of the Department
Apr 2010
University of Sao Paulo, Paulista, Brazil (Professor Farah)
Visiting Professor, DOG-Grant
Jul 2007
Philipps-University, Marburg
ausserplanmässige (apl) Professur
Sep 2006
Rheinische Friedrich-Wilhelms-University, Bonn (Professor Holz)
Deputy chair, Ass Professor
Mar 2004
Venia legendi, Philipps-University, Marburg
Habilitation: Neue Wege in der Diagnostik und operativen Behandlung von makulären Erkrankungen
Aug 2001
Philipps-University, Marburg a.d. Lahn, (Professor Kroll) , Health care management (Professor Lingenfelder)
`Privatdozent`, Faculty Ophthalmochirurgie, hospital management, QM, HR, PR,
Dec 1995 - Dec 1999
University of Lübeck
MD
Apr 1999
Duke University, Durham, NC, USA (Professor Machemer, Toth, Jaffe)
vitreo-retinal Fellowship
Mar 1999
Schleswig-Holstein
`Facharztprüfung` Boards of Ophthalmology
Dec 1995
Albert-Ludwig-University, Freiburg Dr-Thesis, Promotion, summa cum laude
Dr.-Thesis, Promotion, summa cum laude
Dec 1995
med. University of Luebeck (Professor Laqua)
Facharztausbildung `Residency` Ophthalmology
May 1993
Oxford University, UK
Medicine, Spring trimester
Dec 1992
Leopold-Franzens-University, Innsbruck, Austria
Medicine, Winter term
Sep 1992
Ludwig-Maximilians-University, Munich
Medicine, clinical terms
Aug 1989
Dept. Pharmakology, University Hohenheim, (Professor Classen)
experimental studies, Promotion
Oct 1987
Albert-Ludwig-University, Freiburg i. Br.
preclinical terms, Physikum

Experience

Nov 2018
Springer
Best seller (>20.000 downloads) edition of textbook: optical coherence tomography
Jun 2018
J of Oplthalmology
Editorial board member
Mar 2018
Moacyr Álvaro Gold Medal
prestigious recognition in International Ophthalmology, Department of Ophthalmology at the Paulista School of Medicine, Federal University of São Paulo
Jan 2018
world ranking in top 5 peer reviewer on Publons database
cummulative high score (>850) verified reviewer
Dec 2017
Springer’s Top/Best Reviewers 2017 for Graefes Archive Clin Exp Ophthalmol
Best reviewers 2017 due to the quality and amount of 49 reviews
Sep 2017
4 Publons Peer Review Awards 2017
top 1% reviewer in 4 categories: medicine, nation Germany, excellent reviewer, post publication 
Jan 2017
Optical coherence tomography OCT
Springer Textbook editor in chief
Nov 2016
American Journal of Ophthalmology
awarded `Outstanding Reviewer`
Apr 2016
Medical Textbook Award
British Medical Association
Apr 2015
International Journal Viteous Retina
founding Editorial board member
Nov 2014
Graefes Arch Clin Exp Ophthalmol
Editorial board member
Nov 2013
Fellow of the European Board of Ophthalmology (FEBO)
frequent board examiner
Sep 2013
Progress in Chromovitrevtomy
Supplement editor, Ophthalmologica
Apr 2013
Eye
listed in journals 15 best papers in last 25 years
Feb 2013
BioMed Research International
Editorial board member
Dec 2012
Ophthalmic Research
Editorial board member
Nov 2012
Vitreoretinal surgery
Jeybee Textbook editor
Jun 2012
DOC Award
Deutsche Ophthalmochirurgen (DOC) Nürnberg
Jun 2011
DOC Award
Deutsche Ophthalmochirugen (DOC) Nürnberg
Oct 2006 - Mar 2011
Rheinische Friedrich-Wilhelms-Universität Bonn
Lt. Oberarzt Professor of Ophthalmology
Nov 2010
Klin Monatsbl Augenheilkunde
Editorial board member
May 2009
Acta Ophthalmologica
Editorial board member
Feb 2009
International chromovitrectomy collaboration, Lübeck, Bonn, Munich, Sao Paulo
Bundesministerium für Wirtschaft (BMWi) Berlin, research Grant
Nov 2008
AAO Achievement Award
American Academy of Ophthalmology (AAO), Chicago
Jun 2008
Chromovitrectomy: vital dyes in vitreoretinal surgery
Karger Textbook editor
Jan 2007
International Ophthalmology
awarded reviewer
May 2001 - Oct 2006
Philipps-Universität Marburg Fachbereich Medizin
ass Professor, faculty Privatdozent
Nov 2005
VINCE (vitreoretinal internal limiting membrane color enhancer)
DORC Patent https://patents.justia.com/patent/7338477 https://patents.justia.com/patent/20080027396
Sep 2003
Auge und Innere Medizin
Schattauer Textbook editor
Nov 2002
awarded best talk
Rhein-Mainische Augenärzte, Wiesbaden
Nov 1999 - Jun 2002
Duke University Hospital
vitreoretinal fellowship
Mar 1999 - Jun 2001
Duke University
Vitreoretinal Fellow
Jan 2000
Posterior vitreous detachment induced by RDG peptides
US-Patent https://patents.justia.com/patent/20030139342
Nov 1995 - Nov 1999
Luebeck University of Applied Sciences
resident
Apr 1999
Joachin-Ruthlin Award
Barraquer Institudo, Barcelona, Spain
Sep 1998
Chibret Award
International Congress of Ophthalmology, Amsterdam
Apr 1998
Joachin-Ruthlin Award
Barraquer Institudo, Barcelona, Spain
Mar 1993 - Jul 1993
University of Oxford
Mar 1992 - Jun 1992
Innsbruck Medical University
Jan 1989 - Jan 1992
Ludwig-Maximilians-Universitat Munchen
Jan 1987 - Jan 1989
Albert-Ludwigs-Universität Freiburg
Aug 2017
Paulista, Federal University of Sao Paulo (UNIFESP), Brazil
affiliated Professor of Ophthalmology
Nov 2014
Università della Svizzera Italiana
facukty
Nov 2012
University of Lucknow
Visiting Professor

Top co-authors

Sandeep Saxena
Sandeep Saxena

King George's Medical University

23
Eduardo B Rodrigues
Eduardo B Rodrigues

Vision Institute IPEPO

18
Michel Eid Farah
Michel Eid Farah

Federal University of São Paulo

12
Frank G Holz
Frank G Holz

University of Bonn

10
Michel E Farah
Michel E Farah

Federal University of São Paulo

9
Nibha Mishra
Nibha Mishra

Birla Institute of Technology

7
Nicolas Feltgen
Nicolas Feltgen

University of Freiburg

7
Zengping Liu
Zengping Liu

University of Bonn

7
Fernando M Penha
Fernando M Penha

Federal University of São Paulo

6

Publications

305Publications

2648Reads

901PubMed Central Citations

Increased serum level of homocysteine correlates with retinal nerve fiber layer thinning in diabetic retinopathy.

Mol Vis. 2016 Dec 2;22:1352-1360

Mol Vis.

PURPOSE: To study the correlation between serum levels of vitamin B12, folic acid, and homocysteine and the severity of diabetic retinopathy and the correlation with retinal nerve fiber layer (RNFL) thinning on spectral domain optical coherence tomography (SD-OCT). METHODS: In a tertiary care center-based prospective cross-sectional study, 60 consecutive cases and 20 healthy controls in the age group of 40-65 years were included. The eyes of the cases were divided into three groups according to Early Treatment Diabetic Retinopathy Study (ETDRS) classification: diabetes mellitus without retinopathy (n = 20), non-proliferative diabetic retinopathy with macular edema (n = 20), and proliferative diabetic retinopathy with macular edema (n = 20). The serum levels of vitamin B12 and folic acid were measured using a standard protocol. The serum homocysteine assay was performed using an enzyme-linked immunosorbent assay (ELISA) kit. Average RNFL thickness was measured using SD-OCT. Statistical analysis was used to assess the correlations between the study variables. RESULTS: Increased severity of diabetic retinopathy was found to correlate with an increase in the serum levels of homocysteine (F = 53.79; p<0.001). The mean serum levels of vitamin B12 and folic acid were found to be within the normal reference range. A positive correlation was found between retinal nerve fiber layer thinning and serum levels of homocysteine (p<0.001). CONCLUSIONS: This study, for the first time, demonstrated a correlation between increased homocysteine with a decrease in RNFL thickness and increased severity of diabetic retinopathy.

View Article
December 2018
4 Reads

Increased serum level of homocysteine correlates with retinal nerve fiber layer thinning in diabetic retinopathy.

Mol Vis 2016 2;22:1352-1360. Epub 2016 Dec 2.

CSIR - Indian Institute of Toxicology and Research, Lucknow, India.

View Article
January 2018
12 Reads
3 Citations
1.990 Impact Factor

INTRAVITREAL ZIV-AFLIBERCEPT FOR NEOVASCULAR AGE-RELATED MACULAR DEGENERATION: 52-Week Results.

Retina 2017 Dec 11. Epub 2017 Dec 11.

Department of Ophthalmology, Paulista Medical School, Federal University of São Paulo, São Paulo, Brazil.

View Article
December 2017
40 Reads
3.243 Impact Factor

Management of postoperative inflammation after cataract and complex ocular surgeries: a systematic review and Delphi survey.

Br J Ophthalmol 2017 11 3;101(11):1-10. Epub 2017 Aug 3.

Department of Ophthalmology, Joseph Fourier University, Grenoble, France.

View Article
November 2017
29 Reads
2 Citations
2.980 Impact Factor

Subretinal fluid application to close a refractory full thickness macular hole.

Int J Retina Vitreous 2017 27;3:44. Epub 2017 Nov 27.

Pallas Clinics, Bahnhofplatz 2, 5000 Aarau, Switzerland.

View Article
November 2017
6 Reads

[Laser Iridotomy - In Cases of Acute Angle Closure Only?]

Klin Monbl Augenheilkd 2017 Nov 3;234(11):1372-1377. Epub 2017 May 3.

Augenklinik, Universität Bonn.

View Article
November 2017
8 Reads
0.665 Impact Factor

Good News From Switzerland: A History of Retinal Reattachment Surgery Authors: Peter Leaver, Richard Keeler

Authors:
Carsten H Meyer

Graefe's Archive for Clinical and Experimental Ophthalmology 2015; 253 (12), 2345-2345

Graefe's Archive for Clinical and Experimental Ophthalmology

Good News From Switzerland: A History of Retinal Reattachment Surgery Authors: Peter Leaver, Richard Keeler 2013 ISBN: 978-1-85315-993-0 RSM Press CH Meyer Graefe's Archive for Clinical and Experimental Ophthalmology 253 (12), 2345-2345

View Article
November 2017
3 Reads

Management of postoperative inflammation after cataract and complex ocular surgeries: a systematic review and Delphi survey.

Br J Ophthalmol.

Prevention and management of postoperative ocular inflammation with corticosteroids and non-steroidal anti-inflammatory drugs (NSAIDs) have been evaluated in several randomised controlled trials (RCTs). However, neither consensus regarding the efficacies of different regimens nor established guidelines are currently available. This has resulted in different practice patterns throughout the world. A systematic literature review found that for the management of postcataract inflammation nepafenac produced a positive outcome in three of three RCTs (3/3), as did ketorolac (1/1), bromfenac (7/7), loteprednol (3/3) and difluprednate (6/6), but not flurbiprofen (0/1). A single study found that betamethasone produced inconclusive results after retinal detachment (RD) surgery; ketorolac was effective (1/1) after vitrectomy, but triamcinolone was ineffective (0/1) after trabeculectomy. A two-round Delphi survey asked 28 international experts to rate both the inflammatory potential of different eye surgeries and their agreement with different treatment protocols. They rated trabeculectomy, RD surgery and combined phacovitrectomy as more inflammatory than cataract surgery. Vitrectomies for macular hole or epiretinal membrane were not deemed more inflammatory than cataract surgery. For trabeculectomy, they preferred to treat longer than for cataract surgery (NSAID + corticosteroid three times a day for 2 months vs 1 month). For vitrectomy alone, RD surgery and combined phacovitrectomy, the panel preferred the same treatment as for cataract surgery (NSAID + corticosteroid three times a day for 1 month). The discrepancy between preferred treatment and perception of the eye's inflammatory status by the experts for RD and combined vitreoretinal surgeries highlights the need for RCTs to establish treatment guidelines.

View Article
August 2017
2 Reads

IMPACT OF VITREORETINAL INTERFACE ARCHITECTURE ON SUCCESSFUL VITREOMACULAR TRACTION RESOLUTION IN EYES SCHEDULED FOR INTRAVITREAL OCRIPLASMIN THERAPY.

Retina 2017 Jul;37(7):1252-1260

*Department of Ophthalmology, Philipps-University Marburg, Germany; †Institute of Medical Biometry and Epidemiology, Philipps-University Marburg, Marburg, Germany; ‡Department of Ophthalmology, University of Cologne, Cologne, Germany; §Internationale Innovative Ophthalmochirurgie (IIO), Düsseldorf, Germany; ¶Department of Ophthalmology, Knappschaftskrankenhaus Sulzbach, Sulzbach, Germany; **Department of Ophthalmology, Feldkirch State Hospital, Feldkirch, Austria; ††Department of Ophthalmology, Pallas Clinic, Aarau, Switzerland; ‡‡Department of Ophthalmology, Rheinische Friedrich-Wilhelms-University, Bonn, Germany; §§Department of Ophthalmology, Ruprecht-Karls-University Heidelberg, Heidelberg, Germany; and ¶¶Department of Ophthalmology, University Medical Center Goettingen, Goettingen, Germany.

View Article
July 2017
20 Reads
3.243 Impact Factor

Predictive factors for functional improvement following intravitreal bevacizumab injections after central retinal vein occlusion.

Graefes Arch Clin Exp Ophthalmol 2017 05 21;255(5):1045-1046. Epub 2017 Feb 21.

Eye Clinic Sulzbach, Knappschaftsklinikum Saar, Sulzbach, 66280 , Germany.

View Article
May 2017
9 Reads
1.910 Impact Factor

Predictive factors for functional improvement following intravitreal bevacizumab injections after central retinal vein occlusion.

Graefes Arch Clin Exp Ophthalmol 2017 Mar 8;255(3):457-462. Epub 2016 Sep 8.

Eye Clinic Sulzbach, Knappschaftsklinikum Sulzbach Saar, An der Klinik 10, 66111, Sulzbach/Saar, Germany.

View Article
March 2017
23 Reads
1 Citation
1.910 Impact Factor

INCREASED SERUM LEVELS OF UREA AND CREATININE ARE SURROGATE MARKERS FOR DISRUPTION OF RETINAL PHOTORECEPTOR EXTERNAL LIMITING MEMBRANE AND INNER SEGMENT ELLIPSOID ZONE IN TYPE 2 DIABETES MELLITUS.

Retina 2017 Feb;37(2):344-349

*Retina Service, Department of Ophthalmology, King George's Medical University, Lucknow, India;Departments of †Social and Preventive Medicine, and‡Pathology, King George's Medical University, Lucknow, India;§Department of Ophthalmology, Pallas Klinik, Olten, Switzerland;¶Department of Ophthalmology, University of Adelaide, Adelaide, South Australia, Australia;**Department of Cardiovascular Diseases, International Clinical Research Center, St. Anne's University Hospital and Masaryk University, Brno, Czech Republic; and††Department of Ophthalmology, Saint Louis University Eye Institute, Saint Louis University, St. Louis, Missouri.

View Article
February 2017
16 Reads
3.243 Impact Factor

The potential of spectral domain optical coherence tomography imaging based retinal biomarkers.

Int J Retina Vitreous 2017 9;3. Epub 2017 Jan 9.

Harvard Medical School, Massachusetts Eye and Ear, Boston, MA USA.

View Article
January 2017
8 Reads
1 Citation

INTRAVITREAL INJECTIONS OF ZIV-AFLIBERCEPT FOR DIABETIC MACULAR EDEMA: A Pilot Study.

Retina 2016 Sep;36(9):1640-5

Department of Ophthalmology, Federal University of São Paulo-Paulista Medical School, São Paulo, Brazil.

View Article
September 2016
20 Reads
5 Citations
3.243 Impact Factor

Biocompatibility of the vital dye Acid Violet-17 on retinal pigment epithelial cells.

Clin Ophthalmol 2016 29;10:1435-45. Epub 2016 Jul 29.

Department of Ophthalmology, University of Schleswig-Holstein, Lübeck, Germany.

View Article
August 2016
15 Reads

Superior Rim Stability of the Lens Capsule Following Manual Over Femtosecond Laser Capsulotomy.

Invest Ophthalmol Vis Sci 2016 05;57(6):2839-49

Department of Ophthalmology, University of Basel, Basel, Switzerland 6Winterthur Cantonal Hospital, Winterthur, Switzerland 7Centro Ticinese di Chirurgia Ambulatoriale Avanti, Lugano, Switzerland.

View Article
May 2016
13 Reads
1 Citation
3.404 Impact Factor

Association of serum N(ε)-Carboxy methyl lysine with severity of diabetic retinopathy.

J Diabetes Complications 2016 Apr 11;30(3):511-7. Epub 2015 Dec 11.

Developmental Toxicology Division, CSIR- Indian Institute of Toxicology Research, Lucknow, India.

View Article
April 2016
27 Reads
4 Citations
1.925 Impact Factor

Nitric oxide and oxidative stress is associated with severity of diabetic retinopathy and retinal structural alterations.

Clin Exp Ophthalmol 2015 Jul 26;43(5):429-36. Epub 2015 Jun 26.

Developmental Toxicology Division, Indian Institute of Toxicology and Research, Lucknow, India.

View Article
July 2015
8 Reads
8 Citations
1.953 Impact Factor

Investigation of new dyes for chromovitrectomy: preclinical biocompatibility of trisodium, orangell and methyl violet.

Int J Retina Vitreous 2015 15;1. Epub 2015 Apr 15.

grid.411249.b0000000105147202Department of Ophthalmology, Federal University of São Paulo, 821 Botucatu Street, 1st floor, Sao Paulo, CEP Brazil.

View Article
April 2015
11 Reads

Influence of ocular volume and lens status on pharmacokinetics and duration of action of intravitreal vascular endothelial growth factor inhibitors.

Retina 2015 Jan;35(1):69-74

*Department of Ophthalmology, University of Bonn, Bonn, Germany; †Department of Ophthalmology, University of Cologne, Cologne, Germany; and ‡Department of Ophthalmology, Pallas Clinics, Aarau, Switzerland.

View Article
January 2015
21 Reads
5 Citations
3.243 Impact Factor

Peripapillary astrocytic hamartomas evolve from the optic nerve.

BMJ Case Rep 2015 Jan 23;2015. Epub 2015 Jan 23.

Department of Ophthalmology, Pallas Clinic, Olten, Switzerland.

View Article
January 2015
6 Reads

Testing the effects of the dye acid violet-17 on retinal function for an intraocular application in vitreo-retinal surgery.

Graefes Arch Clin Exp Ophthalmol 2014 Dec 14;252(12):1927-37. Epub 2014 Sep 14.

University Eye Hospital, University of Lübeck, Ratzeburger Allee 160, D-23538, Lübeck, Germany.

View Article
December 2014
31 Reads
2 Citations
1.910 Impact Factor

Geometry, penetration force, and cutting profile of different 23-gauge trocars systems for pars plana vitrectomy.

Retina 2014 Nov;34(11):2290-9

*Department of Ophthalmology, University of Bonn, Bonn, Germany; †Eye Clinic Breyer, Dusseldorf, Germany; ‡Department of Ophthalmology, University of Sao Paulo, Sao Paulo, Brazil; and §Department of Ophthalmology, Southwest Hospital, Key Laboratory of Visual Damage and Repair of Chongqing Third Military Medical University, Chongqing, China.

View Article
November 2014
30 Reads
1 Citation
3.243 Impact Factor

[Smartphone-operated detonation of a firecracker resulting in a macular hole].

Ophthalmologe 2014 Nov;111(11):1070-2

Pallas Klinik AG, Louis Giroud-Str. 20, 4600, Olten, Schweiz.

View Article
November 2014
21 Reads
1 Citation
0.720 Impact Factor

[Possibilities for use of Scheimpflug technology in cataract surgery].

Ophthalmologe 2014 Oct;111(10):927-34

Augenzentrum Osthessen, Marktstr. 8, 36037, Fulda, Deutschland,

View Article
October 2014
9 Reads
0.720 Impact Factor

Three-dimensional spectral domain optical coherence tomography in vitreomacular traction.

BMJ Case Rep 2014 Jun 17;2014. Epub 2014 Jun 17.

Department of Ophthalmology, St Louis University, St Louis, Missouri, USA.

View Article
June 2014
8 Reads
2 Citations

Penetration force, geometry, and cutting profile of the novel and old Ozurdex needle: the MONO study.

J Ocul Pharmacol Ther 2014 Jun 6;30(5):387-91. Epub 2014 May 6.

1 Department of Ophthalmology, Pallas Clinic , Aarau, Switzerland .

View Article
June 2014
31 Reads
2 Citations
1.420 Impact Factor

Three-dimensional spectral domain optical coherence tomography in chronic exposure to welding arc.

BMJ Case Rep 2014 May 15;2014. Epub 2014 May 15.

Department of Ophthalmology, Pallas Klinik, Olten, Switzerland.

View Article
May 2014
4 Reads

Retinal biocompatibility of brilliant blue g with deuterated water for chromovitrectomy.

J Ophthalmic Vis Res 2014 Apr;9(2):204-9

Department of Ophthalmology, Vision Institute (IPEPO), Federal University of São Paulo, São Paulo, Brazil.

View Article
April 2014
15 Reads

Effect of novel vital dyes on outer blood-retina barrier function in cultured human retinal pigment epithelium.

Ophthalmologica 2013 6;230 Suppl 2:33-40. Epub 2013 Sep 6.

Department of Ophthalmology, University of Bonn, Bonn, Germany.

View Article
April 2014
27 Reads
1.870 Impact Factor

Progress in chromovitrectomy: 'staining alive'.

Authors:
Carsten H Meyer

Ophthalmologica 2013 6;230 Suppl 2:1-2. Epub 2013 Sep 6.

View Article
April 2014
2 Reads
1.870 Impact Factor

Biochemical analysis and decomposition products of indocyanine green in relation to solvents, dye concentrations and laser exposure.

Ophthalmologica 2013 6;230 Suppl 2:59-67. Epub 2013 Sep 6.

Vision Institute IPEPO, Department of Ophthalmology, Federal University of São Paulo, São Paulo, Brazil.

View Article
April 2014
57 Reads
2 Citations
1.870 Impact Factor

Indocyanine green concentrations used in chromovitrectomy cause a reversible functional alteration in the outer blood-retinal barrier.

Acta Ophthalmol 2014 Mar 29;92(2):e147-55. Epub 2013 Jul 29.

Department of Ophthalmology, University of Bonn, Bonn, Germany.

View Article
March 2014
32 Reads
2 Citations
2.844 Impact Factor

[Ocular pharmacokinetics: Topical, intravitreal, and systemic drug application].

Ophthalmologe 2014 Feb;111(2):104-6

Klinik Pallas AG, Bahnhofplatz 4, 5000, Aarau, Schweiz,

View Article
February 2014
11 Reads
0.720 Impact Factor

[Pharmacokinetics of intravitreally administered VEGF inhibitors].

Ophthalmologe 2014 Feb;111(2):113-20

Universitäts-Augenklinik Bonn, Ernst-Abbe-Str. 2, 53127, Bonn, Deutschland,

View Article
February 2014
6 Reads
2 Citations
0.720 Impact Factor

[Reliability and safety of intravitreal Ozurdex injections. The ZERO study].

Ophthalmologe 2014 Jan;111(1):44-52

Augenklinik Franziskushospital Münster, Münster, Deutschland.

View Article
January 2014
6 Reads
9 Citations
0.720 Impact Factor

Three-dimensional spectral domain optical coherence tomography in Stargardt disease and fundus flavimaculatus.

J Ocul Biol Dis Infor 2012 7;5(1):13-8. Epub 2012 Dec 7.

Department of Ophthalmology, King George's Medical University, Lucknow, India.

View Article
December 2013
2 Reads
1 Citation

Ischaemia-reperfusion injury in central retinal artery occlusion.

BMJ Case Rep 2013 Oct 21;2013. Epub 2013 Oct 21.

Department of Ophthalmology, King George's Medical University, Lucknow, Uttar Pradesh, India.

View Article
October 2013
2 Reads
3 Citations

Status of serum VEGF and ICAM-1 and its association with external limiting membrane and inner segment-outer segment junction disruption in type 2 diabetes mellitus.

Mol Vis 2013 4;19:1760-8. Epub 2013 Aug 4.

Department of Ophthalmology, King George's Medical University, Lucknow, India.

View Article
September 2013
11 Reads
15 Citations
1.990 Impact Factor

[Long-term visual outcome comparison of bilateral implantation of apodised diffractive versus progressive multizonal refractive multifocal intraocular lenses after cataract extraction].

Klin Monbl Augenheilkd 2013 Aug 19;230(8):791-5. Epub 2013 Aug 19.

Zentrum für Augenheilkunde, Pallas Klinik, Aarau, Switzerland.

View Article
August 2013
14 Reads
1 Citation
0.665 Impact Factor

[New options for digital photo documentation during routine examination for ophthalmologists].

Klin Monbl Augenheilkd 2013 Jun 14;230(6):604-10. Epub 2013 May 14.

Augenklinik, Pallas Klinik, Olten, Switzerland.

View Article
June 2013
12 Reads
1 Citation
0.665 Impact Factor

Investigation of the retinal biocompatibility of acid violet for chromovitrectomy.

Graefes Arch Clin Exp Ophthalmol 2013 Apr 18;251(4):1115-21. Epub 2013 Jan 18.

Department of Ophthalmology, Vision Institute (IPEPO), Federal University of São Paulo, São Paulo, Brazil.

View Article
April 2013
15 Reads
3 Citations
1.910 Impact Factor

Three-dimensional spectral domain optical coherence tomography in X linked foveal retinoschisis.

BMJ Case Rep 2013 Apr 5;2013. Epub 2013 Apr 5.

Department of Ophthalmology, KG's Medical University, Lucknow, Uttar Pradesh, India.

View Article
April 2013
3 Reads
3 Citations

[Nintendo 3DS: technology, physiology and possible risks for children's eyes].

Ophthalmologe 2013 Mar;110(3):263-6

Augenklinik, Kantonsspital St.Gallen, Rorschacherstr. 95, Haus 04, 9007, St. Gallen, Schweiz.

View Article
March 2013
6 Reads
1 Citation
0.720 Impact Factor

Vitreous traction after Ozurdex injection.

J Ocul Pharmacol Ther 2013 Feb 25;29(1):3-4. Epub 2012 Oct 25.

View Article
February 2013
3 Reads
3 Citations
1.420 Impact Factor

3D spectral domain OCT in spontaneous retinal pigment epithelial tear.

J Ocul Biol Dis Infor 2012 Dec 25;5(3-4):70-6. Epub 2013 Apr 25.

Department of Ophthalmology, Pallas Klinik, Olten, Switzerland.

View Article
December 2012
1 Read

Intraocular pharmacokinetics of ranibizumab following a single intravitreal injection in humans.

Am J Ophthalmol 2012 Oct 19;154(4):682-686.e2. Epub 2012 Jul 19.

University of Bonn, Department of Ophthalmology, Germany.

View Article
October 2012
6 Reads
26 Citations
3.871 Impact Factor

Three-dimensional spectral domain optical coherence tomography of retina in choroidal metastasis due to uterine endometrial carcinoma.

BMJ Case Rep 2012 Sep 11;2012. Epub 2012 Sep 11.

Department of Ophthalmology, CSM Medical University, Lucknow, Uttar Pradesh, India.

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September 2012
1 Read
3 Citations

Simultaneous confocal scanning laser ophthalmoscopy combined with high-resolution spectral-domain optical coherence tomography: a review.

J Ophthalmol 2011 1;2011:743670. Epub 2011 Nov 1.

Retina Service, Department of Ophthalmology, Federal University of São Paulo, 04021-001 São Paulo, SP, Brazil.

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August 2012
5 Reads
1 Citation
1.940 Impact Factor

Topographic assessment of retinal pigment epithelium detachment in central serous chorioretinopathy by three-dimensional optical coherence tomography single-layer retinal pigment epithelium map.

J Ocul Biol Dis Infor 2012 Jun 31;5(2):44-7. Epub 2013 Jan 31.

Retina Service, Department of Ophthalmology, King George's Medical University, Lucknow, India.

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June 2012
6 Reads

Concentrations of unbound bevacizumab in the aqueous of untreated fellow eyes after a single intravitreal injection in humans.

Acta Ophthalmol 2012 Feb 16;90(1):68-70. Epub 2010 Feb 16.

Department of Ophthalmology, University of Bonn, Bonn, Germany.

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February 2012
2 Reads
4 Citations
2.844 Impact Factor

[Smartphones in ophthalmology : Relief or toys for physicians?].

Ophthalmologe 2012 Jan;109(1):8-20

Universitäts-Augenklinik Bonn, Ernst-Abbe-Str. 2, 53127, Bonn, Deutschland.

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January 2012
12 Reads
3 Citations
0.720 Impact Factor

[Smart ophthalmologists : Smartphones for nothing and the Apps for free?].

Authors:
C H Meyer

Ophthalmologe 2012 Jan;109(1):6-7

Klinik Pallas, Louis Giroud-Str. 20, 4600, Olten, Schweiz.

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January 2012
2 Reads
1 Citation
0.720 Impact Factor

Elevated tumor necrosis factor in serum is associated with increased retinal ischemia in proliferative eales' disease.

Pathobiology 2011 17;78(5):261-5. Epub 2011 Aug 17.

Department of Ophthalmology, CSM Medical University, Lucknow, India. sandeepsaxena2020@ yahoo.com

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January 2012
3 Reads
2 Citations
2.320 Impact Factor

Intraocular pharmacokinetics after a single intravitreal injection of 1.5 mg versus 3.0 mg of bevacizumab in humans.

Retina 2011 Oct;31(9):1877-84

Department of Ophthalmology, University of Bonn, Germany.

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October 2011
5 Reads
28 Citations
3.243 Impact Factor

Incidence and regression of Charles Bonnet syndrome in vascular age-related macular degeneration.

Br J Ophthalmol 2011 Aug 7;95(8):1173-4; author reply 1174. Epub 2011 May 7.

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August 2011
3 Reads
2 Citations
2.980 Impact Factor

Acute keratoconus-like hydrops after laser in situ keratomileusis.

J Ophthalmol 2009 8;2009:363482. Epub 2010 Mar 8.

Department of Ophthalmology, University of Bonn, Ernst-Abbe Street 2, 53127 Bonn, Germany.

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July 2011
1 Read
1.940 Impact Factor

Preclinical aspects of anti-VEGF agents for the treatment of wet AMD: ranibizumab and bevacizumab.

Authors:
C H Meyer F G Holz

Eye (Lond) 2011 Jun 1;25(6):661-72. Epub 2011 Apr 1.

Department of Ophthalmology, University of Bonn, Bonn, Germany.

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June 2011
11 Reads
23 Citations
1.900 Impact Factor

[Sudden unilateral loss of vision under high-dosage corticosteroid therapy for pansinusitis].

Authors:
F Alten C H Meyer

HNO 2011 May;59(5):511-3

Universitäts-Augenklinik Bonn, Ernst-Abbe-Strasse 2, 53127, Bonn, Deutschland.

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May 2011
7 Reads
1 Citation
0.540 Impact Factor

[The role of the vitreous in the pathogenesis of age-related macular degeneration].

Klin Monbl Augenheilkd 2011 May 8;228(5):460-4. Epub 2010 Jul 8.

Klinik für Augenheilkunde, Philipps-Universität Marburg.

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May 2011
15 Reads
2 Citations
0.665 Impact Factor

Effect of needle type and injection technique on pain level and vitreal reflux in intravitreal injection.

J Ocul Pharmacol Ther 2011 Apr 12;27(2):197-203. Epub 2011 Feb 12.

Vision Institute-IPEPO, Department of Ophthalmology, Federal University of São Paulo, São Paulo, Brazil.

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April 2011
49 Reads
16 Citations
1.420 Impact Factor

Novel vitreous modulators for pharmacologic vitreolysis in the treatment of diabetic retinopathy.

Curr Pharm Biotechnol 2011 Mar;12(3):410-22

Department of Ophthalmology, Federal University of São Paulo, Vision Institute, IPEPO, Brazil.

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March 2011
10 Reads
2.511 Impact Factor

Incidence of rhegmatogenous retinal detachments after intravitreal antivascular endothelial factor injections.

Acta Ophthalmol 2011 Feb 22;89(1):70-5. Epub 2010 Dec 22.

Department of Ophthalmology, University of Bonn, Germany.

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February 2011
16 Reads
17 Citations
2.844 Impact Factor

Predictive factors for functional improvement after intravitreal bevacizumab therapy for macular edema due to branch retinal vein occlusion.

Graefes Arch Clin Exp Ophthalmol 2011 Feb 18;249(2):183-92. Epub 2010 Aug 18.

University Eye Clinic Tuebingen, Centre for Ophthalmology, Tuebingen, Germany.

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February 2011
17 Reads
14 Citations
1.910 Impact Factor

Incidence of damage to the crystalline lens during intravitreal injections.

J Ocul Pharmacol Ther 2010 Oct;26(5):491-5

Department of Ophthalmology, University of Bonn , Bonn, Germany.

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October 2010
8 Reads
4 Citations
1.420 Impact Factor

Spectral-domain optical coherence tomography in healed ocular toxoplasmosis.

J Ocul Biol Dis Infor 2010 Sep 10;3(3):109-11. Epub 2011 Aug 10.

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September 2010
6 Reads
1 Citation

Combined intravitreal anti-vascular endothelial growth factor (Avastin) and photodynamic therapy to treat retinal juxtapapillary capillary haemangioma.

Acta Ophthalmol 2010 Aug 12;88(5):610-3. Epub 2009 Feb 12.

Department of Ophthalmology, Philipps-University Marburg, Germany.

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August 2010
4 Reads
8 Citations
2.840 Impact Factor

Time between symptom onset and assessment in age-related macular degeneration with subfoveal choroidal neovascularization.

Ophthalmologica 2010 17;224(3):176-82. Epub 2009 Sep 17.

Department of Ophthalmology, Goethe University Frankfurt am Main, Main, Germany.

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July 2010
17 Reads
3 Citations
1.870 Impact Factor

Choroidal detachment after an uneventful intravitreal injection.

J Ocul Pharmacol Ther 2010 Jun;26(3):305-7

Department of Ophthalmology, University of Bonn, Bonn, Germany.

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June 2010
10 Reads
1 Citation
1.420 Impact Factor

Macular hole formation in the presence of a pigment epithelial detachment after three consecutive intravitreal antivascular endothelial growth factor injections.

J Ocul Pharmacol Ther 2010 Jun;26(3):297-9

Department of Ophthalmology, University of Bonn, Bonn, Germany.

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June 2010
4 Reads
5 Citations
1.420 Impact Factor

Non-mydriatic imaging of a giant retinal tear with the Optos Optomap Panoramic 200MA.

Clin Exp Ophthalmol 2010 May;38(4):427

View Article
May 2010
1 Read
1 Citation
1.953 Impact Factor

[Vital dyes in chromovitrectomy].

Arq Bras Oftalmol 2009 Nov-Dec;72(6):845-50

Setor de Retina e Vítreod, Departamento de Oftalmologia, Universidade Federal de São Paulo, São Paulo, SP,

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May 2010
9 Reads
1 Citation
0.440 Impact Factor

[Current treatment indications and treatment options for retinal astrocytic hamartoma].

Ophthalmologe 2010 Apr;107(4):377-8; author reply 378

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April 2010
3 Reads
0.720 Impact Factor

[Glued eyelids by cyanoacrylate glue (superglue)].

Klin Monbl Augenheilkd 2010 Feb 12;227(2):149-50. Epub 2010 Feb 12.

Augenklinik, Universität Bonn.

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February 2010
1 Read
1 Citation
0.665 Impact Factor

Documentation of congenital hypertrophy of the retinal pigment epithelium with wide-field funduscopy.

Semin Ophthalmol 2009 Nov-Dec;24(6):251-3

Department of Ophthalmology, University of Bonn, Germany.

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February 2010
10 Reads
1.200 Impact Factor

Ability of new vital dyes to stain intraocular membranes and tissues in ocular surgery.

Am J Ophthalmol 2010 Feb 6;149(2):265-77. Epub 2009 Nov 6.

Vision Institute, Department of Ophthalmology, Federal University of São Paulo, São Paulo, Brazil.

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February 2010
14 Reads
10 Citations
3.871 Impact Factor

Enhanced visualisation of the vitreous during bimanual vitreous shaving by trans-scleral illumination.

Br J Ophthalmol 2010 Jan;94(1):140; author reply 140-1

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January 2010
16 Reads
2.980 Impact Factor

Images in clinical medicine. Blurred vision after cardiac catheterization.

N Engl J Med 2009 Dec;361(24):2366

University of Bonn, Bonn, Germany.

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December 2009
13 Reads
2 Citations
55.873 Impact Factor

VEGF inhibitors and vitrectomy for diabetic vitreoretinopathy.

Dev Ophthalmol 2009 3;44:69-81. Epub 2009 Jun 3.

Vision Institute, Department of Ophthalmology, Federal University of Sao Paulo, Sao Paulo, Brazil.

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December 2009
16 Reads
2 Citations

The use of vital dyes in ocular surgery.

Surv Ophthalmol 2009 Sep-Oct;54(5):576-617

Vision Institute IPEPO, Department of Ophthalmology, Federal University of São Paulo, Brazil.

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October 2009
5 Reads
14 Citations
3.850 Impact Factor

Radial optic neurotomy for central retinal vein occlusion: long-term retinal perfusion outcome.

Ophthalmologica 2009 7;223(5):313-9. Epub 2009 May 7.

Department of Ophthalmology, Philipps University Marburg, Marburg, Germany.

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October 2009
17 Reads
3 Citations
1.870 Impact Factor

[Visual self-assessment with the ACTO test during follow-up of AMD patients after intravitreal injections].

Ophthalmologe 2009 Sep;106(9):775-82

Augenklinik Köln, Merheim & ACTO e.V, Ostmerheimer Strasse 200, 51109 Köln.

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September 2009
8 Reads
0.720 Impact Factor

[Different indications of photodynamic therapy in ophthalmology].

Klin Monbl Augenheilkd 2009 Sep 14;226(9):725-39. Epub 2009 Jul 14.

Augenklinik, Universitätsklinikum Ulm.

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September 2009
2 Reads
1 Citation
0.665 Impact Factor

[Modular semiquantitative quality assessment of ophthalmic health information on the internet--reproducibility and correlation between different assessment categories].

Klin Monbl Augenheilkd 2009 Aug 22;226(8):664-71. Epub 2009 Jun 22.

Klinik für Augenheilkunde, Klinikum der Goethe-Universität, Frankfurt/M.

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August 2009
3 Reads
0.665 Impact Factor

Computer-based visual evaluation as a screening tool after intravitreal injections of vascular endothelial growth factor inhibitors.

Ophthalmologica 2008 12;222(6):364-8. Epub 2008 Aug 12.

Department of Ophthalmology, Philipps-University, Marburg, Germany.

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April 2009
18 Reads
1.870 Impact Factor

Transconjunctival 20-gauge vitrectomy: a pilot study.

Ophthalmologica 2009 13;223(1):12-6. Epub 2008 Oct 13.

Retina Department, Hospital Regional Sao Jose, CEPON, Florianopolis, Brazil.

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April 2009
14 Reads
2 Citations
1.870 Impact Factor

[Choriodermie in an asymptomatic heterozygotic female conductor].

Klin Monbl Augenheilkd 2009 Mar 17;226(3):195-7. Epub 2009 Mar 17.

Augenklinik, Universität Bonn, Bonn.

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March 2009
26 Reads
0.665 Impact Factor

Clinical use and research applications of Heidelberg retinal angiography and spectral-domain optical coherence tomography - a review.

Clin Exp Ophthalmol 2009 Jan;37(1):130-43

University Eye Hospital, Hamburg, Germany.

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January 2009
12 Reads
18 Citations
1.950 Impact Factor

Confocal scanning laser ophthalmoscopy findings in chronic solar retinopathy.

Ophthalmic Surg Lasers Imaging 2008 Nov-Dec;39(6):497-9

Department of Ophthalmology, University of Bonn, Ernst-Abbe-Strasse 2, 53127 Bonn, Germany.

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January 2009
1 Read
3 Citations
1.320 Impact Factor

[Dedicated to Professor Peter Knoll on his retirement--a pragmatic innovator].

Klin Monbl Augenheilkd 2008 Dec 15;225(12):1001-2. Epub 2008 Dec 15.

View Article
December 2008
12 Reads
0.665 Impact Factor

[Accessibility of information on eye diseases on the internet for the visually impaired user].

Klin Monbl Augenheilkd 2008 Dec 15;225(12):1075-83. Epub 2008 Dec 15.

Klinik für Augenheilkunde, Klinikum der Johann-Wolfgang-Goethe-Universität, Frankfurt/Main.

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December 2008
4 Reads
0.665 Impact Factor

Lines of Blaschko.

Ophthalmology 2008 Oct;115(10):1855

View Article
October 2008
1 Read
6.130 Impact Factor

Intraocular pharmacokinetics of bevacizumab after a single intravitreal injection in humans.

Am J Ophthalmol 2008 Oct 17;146(4):508-12. Epub 2008 Jul 17.

Department of Ophthalmology, University of Bonn, Bonn, Germany.

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October 2008
4 Reads
61 Citations
3.870 Impact Factor

Trityl dyes patent blue V and brilliant blue G - clinical relevance and in vitro analysis of the function of the outer blood-retinal barrier.

Dev Ophthalmol 2008 ;42:101-14

Department of Ophthalmology, Philipps-University Marburg, Marburg, Germany.

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September 2008
11 Reads
4 Citations

Current concepts of trypan blue in chromovitrectomy.

Dev Ophthalmol 2008 ;42:91-100

Vision Institute, Department of Ophthalmology, Federal University of Sao Paulo, Sao Paulo, Brazil.

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September 2008
15 Reads
3 Citations

Three simple approaches to visualize the transparent vitreous cortex during vitreoretinal surgery.

Dev Ophthalmol 2008 ;42:35-42

Department of Ophthalmology, Philipps-University, Marburg, Germany.

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September 2008
4 Reads
3 Citations

Historical aspects and evolution of the application of vital dyes in vitreoretinal surgery and chromovitrectomy.

Dev Ophthalmol 2008 ;42:29-34

Department of Ophthalmology, Federal University of Sao Paulo, Sao Paulo, Brazil.

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September 2008
11 Reads

A vitrectomy is done, when the vitreous is gone!

Authors:
Carsten H Meyer

Dev Ophthalmol 2008 ;42:1-4

Department of Ophthalmology, University of Bonn, Bonn, Germany.

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September 2008
5 Reads

Combined treatment of acute subretinal haemorrhages with intravitreal recombined tissue plasminogen activator, expansile gas and bevacizumab: a retrospective pilot study.

Acta Ophthalmol 2008 Aug 24;86(5):490-4. Epub 2008 Jan 24.

Department of Ophthalmology, University of Bonn, Germany.

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August 2008
1 Read
13 Citations
2.840 Impact Factor

Secondary pigmented macular pucker on optical coherence tomography.

Acta Ophthalmol 2008 Aug 5;86(5):579-81. Epub 2007 Oct 5.

Department of Ophthalmology, Philipps University, Marburg, Germany.

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August 2008
12 Reads
2.840 Impact Factor

[Bonner record form: documentation of relevant parameters during intravitreal drug application].

Authors:
C H Meyer F G Holz

Klin Monbl Augenheilkd 2008 Jul;225(7):629-31

Augenklinik, Universität Bonn.

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July 2008
3 Reads
0.665 Impact Factor

Posterior vitreomacular adhesion: a potential risk factor for exudative age-related macular degeneration.

Am J Ophthalmol 2008 Jun;145(6):1107; author reply 1107-8

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June 2008
6 Reads
1 Citation
3.870 Impact Factor

[Anatomical and functional results after macular hole surgery].

Klin Monbl Augenheilkd 2008 Mar;225(3):220-6

Augenklinik, Universität Bonn.

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March 2008
2 Reads
2 Citations
0.665 Impact Factor

Meta-analysis of chromovitrectomy with indocyanine green in macular hole surgery.

Ophthalmologica 2008 22;222(2):123-9. Epub 2008 Feb 22.

Department of Ophthalmology, Philipps University Marburg, Marburg, Germany.

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March 2008
2 Reads
5 Citations
1.870 Impact Factor

[Monitoring of AMD patients on anti-vascular endothelial growth factor (VEGF) treatment. Practical notes on functional and anatomical examination parameters from drug approval studies, specialist information and case series].

Ophthalmologe 2008 Feb;105(2):125-38, 140-2

Augenklinik, Universitätsklinikum Bonn, Ernst-Abbe-Strasse 2, 53127, Bonn, Germany.

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February 2008
3 Reads
0.720 Impact Factor

[Intravitreal injection. Monitoring to avoid postoperative complications].

Ophthalmologe 2008 Feb;105(2):143-55, 157

Augenklinik, Universitätsklinikum Bonn, Ernst-Abbe-Strasse 2, 53127, Bonn, Germany.

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February 2008
2 Reads
1 Citation
0.720 Impact Factor

'Ab interno' intravitreal suturing of a large traumatic scleral perforation at the posterior pole.

Br J Ophthalmol 2007 Dec;91(12):1721-2

Dept. of Ophthalmology, University of Bonn, Ernst-Abbe-Strasse 2, 53127 Bonn, Germany.

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December 2007
63 Reads
2.980 Impact Factor

Metrorrhagia after intravitreal injection of bevacizumab.

Acta Ophthalmol Scand 2007 Dec 23;85(8):915-6. Epub 2007 Jul 23.

View Article
December 2007
4 Reads

Emerging pharmacotherapies for diabetic macular edema.

Expert Opin Emerg Drugs 2007 Nov;12(4):591-603

Federal University of Sao Paulo, Vision Institute, Department of Ophthalmology, Sao Paulo, Brazil.

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November 2007
5 Reads
1 Citation
3.060 Impact Factor

Ocular photodynamic therapy--standard applications and new indications. Part 2. Review of the literature and personal experience.

Ophthalmologica 2007 ;221(5):282-91

Department of Ophthalmology, Philipps University, Marburg, Germany.

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November 2007
2 Reads
1 Citation
1.870 Impact Factor

Functional and anatomical investigations in racemose haemangioma.

Acta Ophthalmol Scand 2007 Nov 17;85(7):764-71. Epub 2007 Aug 17.

Department of Ophthalmology, Philipps University, Marburg, Germany.

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November 2007
11 Reads
1 Citation

[Unclear sterile corneal ulcer in a psychologically disturbed patient].

Ophthalmologe 2007 Oct;104(10):892-5

Zentrum für Augenheilkunde, Philipps-Universität Marburg, 35037, Marburg.

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October 2007
5 Reads
0.720 Impact Factor

Mechanisms of intravitreal toxicity of indocyanine green dye: implications for chromovitrectomy.

Retina 2007 Sep;27(7):958-70

Retina Department, Hospital Regional Sao Jose, Instituto de Olhos Florianopolis, Centro Oftalmologico, Florianopolis, Brazil.

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September 2007
31 Reads
8 Citations
3.240 Impact Factor

[Glaucoma drainage system according to Molteno for therapy-resistant glaucoma--a two-stage surgical technique to avoid postoperative hypertension].

Klin Monbl Augenheilkd 2007 Aug;224(8):641-6

Klinik für Augenheilkunde, Philipps-Universität Marburg.

View Article
August 2007
4 Reads
0.665 Impact Factor

Ocular photodynamic therapy--standard applications and new indications (part 1). Review of the literature and personal experience.

Ophthalmologica 2007 ;221(4):216-26

Department of Ophthalmology, Philipps University Marburg, Robert-Koch-Strasse 4, DE-35037 Marburg, Germany.

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July 2007
3 Reads
4 Citations
1.870 Impact Factor

[Pannus-like corneal opacification and multiple mesenchymal anomalies in a 6-year-old boy].

Ophthalmologe 2007 Jul;104(7):601-2

Philipps-Universität Marburg, Robert-Koch-Strasse 4, 35037 Marburg, Deutschland.

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July 2007
8 Reads
0.720 Impact Factor

Tunneled scleral incision to prevent vitreal reflux after intravitreal injection.

Am J Ophthalmol 2007 Jun;143(6):1035-7

Retina Department, Hospital Regional São Jose, Centro Oftalmológico, Florianópolis, Brazil.

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June 2007
12 Reads
6 Citations
3.870 Impact Factor

[Treatment of neovascular age-related macular degeneration with antiangiogenic drugs].

Arq Bras Oftalmol 2006 Sep-Oct;69(5):756-65

Departamento de Retina, Serviço de Oftalmologia, Hospital Regional São José, Instituto de Olhos Florianópolis - Centro Oftalmológico - Florianópolis (SC) - Brasil.

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June 2007
4 Reads
0.440 Impact Factor

Retinal pigment epithelial tears after intravitreal bevacizumab injection for neovascular age-related macular degeneration.

Retina 2007 Jun;27(5):541-51

Southern California Desert Retina Consultants, Palm Springs, CA 92263, USA.

View Article
June 2007
22 Reads
20 Citations
3.240 Impact Factor

Vital dyes for chromovitrectomy.

Curr Opin Ophthalmol 2007 May;18(3):179-87

Vision Institute IPEPO, Department of Ophthalmology, Federal University of São Paulo, São Paulo, Brazil.

View Article
May 2007
5 Reads
10 Citations
2.500 Impact Factor

Current treatment approaches in diabetic macular edema.

Authors:
Carsten H Meyer

Ophthalmologica 2007 ;221(2):118-31

Department of Ophthalmology, Philipps University, Marburg, Germany.

View Article
May 2007
2 Reads
11 Citations
1.870 Impact Factor

Effects of subretinal injection of patent blue and trypan blue in rabbits.

Curr Eye Res 2007 Apr;32(4):309-17

Ophthalmology Department, Paulista School of Medicine, Vision Institute, Federal University of Sao Paulo, Brazil.

View Article
April 2007
16 Reads
5 Citations
1.663 Impact Factor

Complete resorption of retinal hemorrhages in idiopathic thrombocytopenic purpura.

Eur J Ophthalmol 2007 Jan-Feb;17(1):128-9

Department of Ophthalmology, University of Bonn, Bonn, Germany.

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April 2007
3 Reads
1 Citation
1.060 Impact Factor

Current treatment modalities for exudative retinal hamartomas secondary to tuberous sclerosis: review of the literature.

Acta Ophthalmol Scand 2007 Mar;85(2):127-32

Department of Ophthalmology, Philipps-University Marburg, Marburg, Germany.

View Article
March 2007
21 Reads
10 Citations

[Pars-plana vitrectomy with anterior chamber infusion via a paracentesis in pseudophakic eyes].

Ophthalmologe 2007 Mar;104(3):222-5

Klinik für Augenheilkunde, Philipps-Universität Marburg, Robert-Koch-Strasse 4, 35037 Marburg.

View Article
March 2007
1 Read
0.720 Impact Factor

Visual hallucinations after intravitreal injection of bevacizumab in vascular age-related macular degeneration.

Am J Ophthalmol 2007 Jan 7;143(1):169-70. Epub 2006 Sep 7.

Department of Ophthalmology, Philipps University, Robert-Koch-Strasse 4, 35037 Marburg, Germany.

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January 2007
6 Reads
5 Citations
3.871 Impact Factor

High incidence of vitreomacular traction in recurrent choroidal neovascularisation after repeated photodynamic therapy.

Br J Ophthalmol 2006 Nov 19;90(11):1361-2. Epub 2006 Jul 19.

Department of Ophthalmology, Philipps-University Marburg, Robert-Koch-Strasse 4, 35037 Marburg, Germany.

View Article
November 2006
1 Read
4 Citations
2.980 Impact Factor

Functional and anatomical findings in acute Purtscher's retinopathy.

Ophthalmologica 2006 ;220(5):343-6

Department of Ophthalmology, Philipps University Marburg, Marburg, Germany.

View Article
October 2006
7 Reads
3 Citations
1.870 Impact Factor

Vitreomacular traction, macular hole formation, and subfoveal choroidal neovascularization in a patient with age-related macular degeneration.

Authors:
C H Meyer S Mennel

Eye (Lond) 2006 Sep 7;20(9):1090-2. Epub 2005 Oct 7.

View Article
September 2006
2 Reads
1 Citation
1.900 Impact Factor

Adverse effects of cyclooxygenase-2 inhibitors on ocular vision.

Arch Ophthalmol 2006 Sep;124(9):1368; author reply 1368

View Article
September 2006
7 Reads
4.400 Impact Factor

Occult vitreo-macular traction may cause traumatic RPE tears.

Acta Ophthalmol Scand 2006 Aug;84(4):560; author reply 561

View Article
August 2006
4 Reads

Effect of photodynamic therapy on the function of the outer blood-retinal barrier in an in vitro model.

Graefes Arch Clin Exp Ophthalmol 2006 Aug 19;244(8):1015-21. Epub 2006 Jan 19.

Department of Ophthalmology, Philipps-University Marburg, Robert-Koch-Str. 4, 35037, Marburg, Germany.

View Article
August 2006
28 Reads
4 Citations
1.910 Impact Factor

[Influence of vital dyes on the function of the outer blood-retinal barrier in vitro].

Klin Monbl Augenheilkd 2006 Jul;223(7):568-76

Zentrum für Augenheilkunde, Philipps-Universität Marburg, Robert-Koch-Strasse 4, 35037 Marburg.

View Article
July 2006
10 Reads
1 Citation
0.665 Impact Factor

Visual recovery after scleral buckling surgery in macula-off rhegmatogenous retinal detachment.

Ophthalmologica 2006 ;220(3):174-80

Department of Ophthalmology, Philipps University Marburg, Marburg, Germany.

View Article
June 2006
34 Reads
11 Citations
1.870 Impact Factor

Patent blue: a novel vital dye in vitreoretinal surgery.

Ophthalmologica 2006 ;220(3):190-3

Department of Ophthalmology, Philipps University Marburg, Marburg, Germany.

View Article
June 2006
17 Reads
4 Citations
1.870 Impact Factor

[Asymptomatic concentric visual field deficits and optic nerve atrophy].

Ophthalmologe 2006 Jun;103(6):530-2

Klinik für Augenheilkunde, Philipps-Universität, Robert-Koch-Strasse 4, 35037 Marburg.

View Article
June 2006
23 Reads
0.720 Impact Factor

Photodynamic therapy for exudative hamartoma in tuberous sclerosis.

Arch Ophthalmol 2006 Apr;124(4):597-9

Department of Ophthalmology, Philipps University, Marburg, Germany.

View Article
April 2006
10 Reads
6 Citations
4.400 Impact Factor

Which treatment is best for which AMD patient?

Authors:
P Kroll C H Meyer

Br J Ophthalmol 2006 Feb;90(2):128-30

View Article
February 2006
13 Reads
6 Citations
2.980 Impact Factor

Persistent premacular cavity after membranotomy in valsalva retinopathy evident by optical coherence tomography.

Retina 2006 Jan;26(1):116-8

Department of Ophthalmology, Philipps-University, Marburg, Germany.

View Article
January 2006
5 Reads
11 Citations
3.243 Impact Factor

Is the location of valsalva hemorrhages submembranous or subhyaloidal?

Am J Ophthalmol 2006 Jan;141(1):231; author reply 231-2

View Article
January 2006
1 Read
7 Citations
3.871 Impact Factor

Autofluorescence and angiographic findings of retinal astrocytic hamartomas in tuberous sclerosis.

Ophthalmologica 2005 Nov-Dec;219(6):350-6

Department of Ophthalmology, Philipps University Marburg, Germany.

View Article
January 2006
14 Reads
5 Citations
1.870 Impact Factor

Distal arthrogryposis type 2A may be associated with juvenile glaucoma.

Am J Med Genet A 2005 Dec;139A(2):167-8

View Article
December 2005
11 Reads
2.160 Impact Factor

Benefits and side effects of bandage soft contact lens application after LASIK: a prospective randomized study.

Ophthalmology 2005 Dec 12;112(12):2180-3. Epub 2005 Oct 12.

Department of Ophthalmology, Philipps University, Marburg, Germany.

View Article
December 2005
53 Reads
1 Citation
6.135 Impact Factor

[Toxic endophthalmitis].

Ophthalmologe 2005 Nov;102(11):1099-101

Klinik für Augenheilkunde, Philipps-Universität Marburg.

View Article
November 2005
1 Read
0.720 Impact Factor

[Unilateral facial swelling and vision impairment].

Ophthalmologe 2005 Nov;102(11):1102-4

Zentrum für Augenheilkunde, Philipps-Universität, Marburg.

View Article
November 2005
3 Reads
0.720 Impact Factor

Transient serous retinal detachment in classic and occult choroidal neovascularization after photodynamic therapy.

Am J Ophthalmol 2005 Oct;140(4):758-60

Department of Ophthalmology, Philipps-University, Marburg, Germany.

View Article
October 2005
16 Reads
7 Citations
3.871 Impact Factor

Anterior chamber width measurement.

Ophthalmology 2005 Sep;112(9):1638-9

View Article
September 2005
5 Reads
1 Citation
6.135 Impact Factor

Intravitreal staining of the internal limiting membrane using indocyanine green in the treatment of macular holes.

Ophthalmologica 2005 Sep-Oct;219(5):251-62

Department of Ophthalmology, Philipps University Marburg, Germany.

View Article
September 2005
4 Reads
5 Citations
1.870 Impact Factor

Risk of retinal vein occlusions in patients treated with rofecoxib (vioxx).

Ophthalmologica 2005 Jul-Aug;219(4):243-7

Department of Ophthalmology, Philipps University, Marburg, Germany.

View Article
September 2005
26 Reads
2 Citations
1.870 Impact Factor

[Subjective decrease of visual acuity after photodynamic therapy: documentation by optical coherence tomography and its correlation with visual acuity].

Arch Soc Esp Oftalmol 2005 Jul;80(7):413-6

Augenklinik der Philipps Universität Marburg, Germany.

View Article
July 2005
10 Reads

Optical coherence tomography in photodynamic therapy.

Br J Ophthalmol 2005 Jul;89(7):928-9

View Article
July 2005
2.980 Impact Factor

Long-term results after bare sclera pterygium resection with excimer smoothing and local application of mitomycin C.

Cornea 2005 May;24(4):378-81

Department of Ophthalmology, Centro Klinik, Oberhausen, Germany.

View Article
May 2005
9 Reads
4 Citations
2.360 Impact Factor

A novel applicator for the selective painting of pre-retinal structures during vitreoretinal surgery.

Graefes Arch Clin Exp Ophthalmol 2005 May 10;243(5):487-9. Epub 2004 Dec 10.

Department of Ophthalmology, Philipps University, Robert Koch Strasse 4, 35033 Marburg, Germany.

View Article
May 2005
11 Reads
1 Citation
1.910 Impact Factor

[Does insulin glargin (lantus) lead to a progression in diabetic retinopathy?].

Klin Monbl Augenheilkd 2005 Apr;222(4):353-4

View Article
April 2005
0.665 Impact Factor

Transient visual disturbance after photodynamic therapy.

Am J Ophthalmol 2005 Apr;139(4):748-9; author reply 749

View Article
April 2005
9 Reads
3.871 Impact Factor

Chromovitrectomy: a new field in vitreoretinal surgery.

Graefes Arch Clin Exp Ophthalmol 2005 Apr 10;243(4):291-3. Epub 2004 Dec 10.

View Article
April 2005
14 Reads
11 Citations
1.910 Impact Factor

Sheathotomy to decompress BRVO.

Ophthalmology 2005 Mar;112(3):528-9

View Article
March 2005
5 Reads
6.135 Impact Factor

Dynamic mechanical properties of human lenses.

Exp Eye Res 2005 Mar;80(3):425-34

Applied Research, AMO Groningen b.v., P.O. Box 901, 9700 NX, Groningen, The Netherlands.

View Article
March 2005
21 Reads
39 Citations
2.710 Impact Factor

Nutritional supplementation to prevent cataract formation.

Dev Ophthalmol 2005 ;38:103-19

Department of Ophthalmology, Philipps University of Marburg, Marburg, Germany.

View Article
February 2005
16 Reads
8 Citations

Retinal striae after surgical and spontaneous ILM-peeling.

Am J Ophthalmol 2005 Feb;139(2):396; author reply 396-7

View Article
February 2005
10 Reads
3.871 Impact Factor

Anterior segment anomaly on optical coherence tomography.

Acta Ophthalmol Scand 2005 Feb;83(1):118-9

View Article
February 2005
10 Reads
1 Citation

Functional changes after photodynamic therapy with verteporfin.

Am J Ophthalmol 2005 Jan;139(1):214-5

Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina 27710-3802, USA.

View Article
January 2005
4 Reads
1 Citation
3.871 Impact Factor

[Vision impairment by COX-2 inhibitor and the sequelae of voluntary Vioxx recall].

Authors:
C H Meyer

Klin Monbl Augenheilkd 2005 Jan;222(1):62-3

View Article
January 2005
10 Reads
0.665 Impact Factor

[Juvenile glaucoma, cataract and tooth abnormalities in a young patient].

Ophthalmologe 2005 Jan;102(1):82-5

Zentrum für Augenheilkunde, Philipps-Universität, Marburg.

View Article
January 2005
9 Reads
0.720 Impact Factor

Photodynamic therapy and indocyanine green guided feeder vessel photocoagulation of choroidal neovascularization secondary to choroid rupture after blunt trauma.

Graefes Arch Clin Exp Ophthalmol 2005 Jan 4;243(1):68-71. Epub 2004 Aug 4.

Department of Ophthalmology, Philipps-University Marburg, Robert-Koch-Str. 4, 35037 Marburg, Germany.

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January 2005
2 Reads
2 Citations
1.910 Impact Factor

A simple technique to fixate the bullet pipe and perform bimanual vitreous surgery.

Indian J Ophthalmol 2004 Dec;52(4):337-8

View Article
December 2004
13 Reads
1 Citation
0.930 Impact Factor

Spontaneous separation of epiretinal membrane in young subjects: personal observations and review of the literature.

Graefes Arch Clin Exp Ophthalmol 2004 Dec 9;242(12):977-85. Epub 2004 Jun 9.

Department of Ophthalmology, Philipps University Marburg, Robert-Koch-Strasse 4, 35037 Marburg, Germany.

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December 2004
4 Reads
9 Citations
1.910 Impact Factor

Optical coherence tomography in a case of Bietti's crystalline dystrophy.

Acta Ophthalmol Scand 2004 Oct;82(5):609-12

Department of Ophthalmology, Philipps University Marburg, Marburg, Germany.

View Article
October 2004
1 Read
3 Citations

Dislocation of the lenses.

N Engl J Med 2004 Oct;351(18):1913-4

View Article
October 2004
2 Reads
55.873 Impact Factor

Unsealed sclerotomy after intravitreal injection with a 30-gauge needle.

Retina 2004 Oct;24(5):810-2

Department of Ophthalmology, Philipps-University, Marburg, Germany.

View Article
October 2004
14 Reads
3.243 Impact Factor

A modified technique to stain the internal limiting membrane with indocyanine green.

Ophthalmologica 2004 May-Jun;218(3):176-9

Department of Ophthalmology, Philipps University, Marburg, Germany.

View Article
June 2004
9 Reads
1 Citation
1.870 Impact Factor

[Massive subretinal hemorrhages. A challenge for vitreous body surgeons].

Ophthalmologe 2004 Jun;101(6):584-8

Klinik für Augenheilkunde, Philipps-Universität, Marburg.

View Article
June 2004
12 Reads
2 Citations
0.720 Impact Factor

[Chorioretinitis of uncertain origin in a young man].

Ophthalmologe 2004 May;101(5):518-20

Augenklinik, Philipps-Universität, Marburg.

View Article
May 2004
3 Reads
1 Citation
0.720 Impact Factor

Radial optic neurotomy needs evaluation in a controlled prospective trial.

Ophthalmologica 2004 Mar-Apr;218(2):144; author reply 145-6

View Article
April 2004
3 Reads
1.870 Impact Factor

Unilateral linear hyperpigmentation of the skin with ipsilateral sectorial hyperpigmentation of the retina.

Am J Med Genet A 2004 Apr;126A(1):89-92

Department of Ophthalmology, Philipp University of Marburg, Marburg, Germany.

View Article
April 2004
7 Reads
2.160 Impact Factor

Evaluation of granular corneal dystrophy with optical coherent tomography.

Cornea 2004 Apr;23(3):270-1

Department of Ophthalmology, Philipps-University, Marburg, Germany.

View Article
April 2004
1 Read
4 Citations
2.360 Impact Factor

Toxic effects of intravitreal indocyanine green on neuroretinal cells.

Arch Ophthalmol 2004 Apr;122(4):663; author reply 664

View Article
April 2004
14 Reads
4.400 Impact Factor

Optic disc pit maculopathy after blunt ocular trauma.

Eur J Ophthalmol 2004 Jan-Feb;14(1):71-3

The Department of Ophthalmology, Philipps-University Marburg, Marburg, Germany.

View Article
April 2004
3 Reads
1 Citation
1.060 Impact Factor

Acute commotio retinae determined by cross-sectional optical coherence tomography.

Eur J Ophthalmol 2003 Nov-Dec;13(9-10):816-8

Department of Ophthalmology, Philipps-University Marburg, Germany.

View Article
March 2004
8 Reads
6 Citations
1.060 Impact Factor

Reduced concentration and incubation of intravitreal indocyanine green can improve the functional outcome in macular hole surgery.

Am J Ophthalmol 2004 Feb;137(2):386; author reply 386-7

View Article
February 2004
14 Reads
1 Citation
3.871 Impact Factor

Is membrane extraction in cases of exudative age-related macular degeneration still up-to-date? A 4-year résumé.

Ophthalmologica 2003 Nov-Dec;217(6):401-7

Zentrum für Augenheilkunde, Philipps-Universität Marburg, Marburg, Deutschland.

View Article
January 2004
1 Citation
1.870 Impact Factor

Trypan blue has a high affinity to cellular structures such as epiretinal membrane.

Am J Ophthalmol 2004 Jan;137(1):207-8; author reply 208

View Article
January 2004
5 Reads
3 Citations
3.871 Impact Factor

Primary vitrectomy in complicated rhegmatogenous retinal detachment--a survey of 205 eyes.

Ophthalmologica 2003 Nov-Dec;217(6):387-92

Department of Ophthalmology, Philipps University, Marburg, Germany.

View Article
January 2004
11 Reads
9 Citations
1.870 Impact Factor

Sutureless vitrectomy surgery.

Ophthalmology 2003 Dec;110(12):2427-8; author reply 2428

View Article
December 2003
2 Reads
3 Citations
6.135 Impact Factor

Trypan blue stains the epiretinal membrane but not the internal limiting membrane.

Br J Ophthalmol 2003 Nov;87(11):1431-2

View Article
November 2003
6 Reads
3 Citations
2.980 Impact Factor

Therapeutic strategies in choroidal neovascularizations secondary to angioid streaks.

Am J Ophthalmol 2003 Sep;136(3):580-2; author reply 582-3

View Article
September 2003
2 Reads
2 Citations
3.871 Impact Factor

Foveal hypoplasia demonstrated in vivo with optical coherence tomography.

Am J Ophthalmol 2003 Aug;136(2):397; author reply 397-8

View Article
August 2003
1 Read
1 Citation
3.871 Impact Factor

Rosai-Dorfman disease with bilateral serous retinal detachment.

Arch Ophthalmol 2003 May;121(5):733-5

Department of Ophthalmology, Philipps University-Marburg, Germany.

View Article
May 2003
14 Reads
2 Citations
4.400 Impact Factor

Staining of internal limiting membrane in vitreomacular surgery: a simplified technique.

Retina 2003 Apr;23(2):263-4; author reply 264

View Article
April 2003
13 Reads
2 Citations
3.243 Impact Factor

RGD peptide-assisted vitrectomy to facilitate induction of a posterior vitreous detachment: a new principle in pharmacological vitreolysis.

Curr Eye Res 2002 Dec;25(6):333-40

Department of Ophthalmology, Duke University Medical Center, NC 27710, USA.

View Article
December 2002
4 Reads
2 Citations
1.663 Impact Factor

Effect of INS37217, a P2Y(2) receptor agonist, on experimental retinal detachment and electroretinogram in adult rabbits.

Invest Ophthalmol Vis Sci 2002 Nov;43(11):3567-74

Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina 27710, USA.

View Article
November 2002
22 Reads
10 Citations
3.404 Impact Factor

Visual outcomes following macular translocation with 360-degree peripheral retinectomy.

Arch Ophthalmol 2002 Oct;120(10):1317-24

Department of Ophthalmology, VitreoretinalService, Duke University Medical Center, Durham, NC 27710, USA.

View Article
October 2002
11 Reads
13 Citations
4.400 Impact Factor

Central retinal vein occlusion in a patient with rheumatoid arthritis taking rofecoxib.

Lancet 2002 Oct;360(9339):1100

View Article
October 2002
16 Reads
45.220 Impact Factor

[When is congenital hypertrophy of the retinal pigment epithelium (CHRPE) associated with the Gardner's syndrome? An overview with clinical examples].

Klin Monbl Augenheilkd 2002 Sep;219(9):644-8

Zentrum für Augenheilkunde, Philipps-Universität Marburg, Marburg, Germany.

View Article
September 2002
47 Reads
0.665 Impact Factor

[Increased lens opacity, retinal pigment epithelium degeneration and spontaneous retinal detachment in a family. Wagner syndrome].

Authors:
C H Meyer

Ophthalmologe 2002 Aug;99(8):654-5

Zentrum für Augenheilkunde, Philipps-Universität Marburg.

View Article
August 2002
1 Read
0.720 Impact Factor

Decreased visual acuity associated with cystoid macular edema in neovascular age-related macular degeneration.

Arch Ophthalmol 2002 Jun;120(6):731-7

Department of Ophthalmology, Duke University Medical Center, Box 3802, Erwin Road, Durham, NC 27710, USA.

View Article
June 2002
10 Reads
15 Citations
4.400 Impact Factor

Foveal hypoplasia in oculocutaneous albinism demonstrated by optical coherence tomography.

Am J Ophthalmol 2002 Mar;133(3):409-10

Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina 27710, USA.

View Article
March 2002
13 Reads
9 Citations
3.871 Impact Factor

Age-related changes in vitreous mobility as measured by video B scan ultrasound.

Exp Eye Res 2002 Feb;74(2):173-80

Department of Ophthalmology, Duke University Medical Center, Erwin Road, Durham, NC 27710, U.S.A.

View Article
February 2002
1 Read
9 Citations
2.710 Impact Factor

Successful macular translocation with temporary scleral infolding using absorbable sture.

Retina 2001 ;21(4):304-11

Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina, USA.

View Article
December 2001
12 Reads
1 Citation
3.243 Impact Factor

Macular translocation with radial scleral ouffolding: experimental studies and initial human results.

Graefes Arch Clin Exp Ophthalmol 2001 Nov;239(11):815-23

Delmarva Vitreoretinal Center, Salisbury, Maryland, USA.

View Article
November 2001
10 Reads
1 Citation
1.910 Impact Factor

Induced corneal astigmatism after macular translocation surgery with scleral infolding.

Ophthalmology 2001 Jul;108(7):1203-8

Cornea Service, Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina 27710-3802, USA.

View Article
July 2001
12 Reads
6.135 Impact Factor

Retinal pigment epithelial tear with vitreomacular attachment: a novel pathogenic feature.

Authors:
C H Meyer C A Toth

Graefes Arch Clin Exp Ophthalmol 2001 Jun;239(5):325-33

Duke University Medical Center, Department of Ophthalmology, Durham, NC 27710, USA.

View Article
June 2001
6 Reads
6 Citations
1.910 Impact Factor

Spectral analysis of viscoelasticity of the human lens.

J Refract Surg 1999 Nov-Dec;15(6):714-6

Institute for Dynamic Materials Testing and Department of Applied Physics, University of Ulm, Germany.

View Article
February 2000
10 Reads
7 Citations
3.470 Impact Factor

Experimental animal myopia models are applicable to human juvenile-onset myopia.

Surv Ophthalmol 1999 Oct;44 Suppl 1:S93-102

Department of Ophthalmology, Medical University, Lübeck, Germany.

View Article
October 1999
12 Reads
7 Citations
3.850 Impact Factor

Max Linde, MD, a Luebeck ophthalmologist and patron of Edvard Munch.

Authors:
C Meyer

Surv Ophthalmol 1999 May-Jun;43(6):525-34

Medical University of Luebeck, Germany.

View Article
September 1999
8 Reads
1 Citation
3.850 Impact Factor

[Lipid metabolism in retinal pigment epithelium. Possible significance of lipoprotein receptors].

Ophthalmologe 1998 Dec;95(12):814-9

Augenklinik, Medizinische Universität zu Lübeck.

View Article
December 1998
8 Reads
4 Citations
0.720 Impact Factor

[Prognosis of keratoplasty in keratitis scrophulosa peracta].

Authors:
C Meyer H J Meyer

Klin Monbl Augenheilkd 1998 Dec;213(6):315-9

Klinik für Augenheilkunde der Universität Lübeck.

View Article
December 1998
14 Reads
0.665 Impact Factor

Effects on tropical fish of soil sediments from Kafue river, Zambia.

Bull Environ Contam Toxicol 1998 Jul;61(1):96-101

University of Zambia, School of Veterinary Medicine, Department of Paraclinical Studies, Lusaka, Zambia.

View Article
July 1998
1 Citation
1.255 Impact Factor

[Transplantation of autologous submandibular glands in very severe keratoconjunctivitis sicca. 2 year outcome].

Ophthalmologe 1998 Apr;95(4):257-65

Klinik für Augenheilkunde, Medizinische Universität Lübeck.

View Article
April 1998
3 Reads
2 Citations
0.720 Impact Factor

[How well do sunglasses protect from damaging UV rays?].

Authors:
M Clausen C Meyer

Klin Monbl Augenheilkd 1998 Feb;212(2):aA9-13

Klinik für Augenheilkunde, Medizinische Universität Lubeck.

View Article
February 1998
4 Reads
0.665 Impact Factor

Patient expectations and recollection of information about photorefractive keratectomy.

J Cataract Refract Surg 1997 Nov;23(9):1311-6

Department of Ophthalmology, Medical University of Lübeck, Germany.

View Article
November 1997
2.722 Impact Factor

[Keratoplasty of pseudophakic eyes with posterior chamber lenses in Fuchs' dystrophy and secondary bullous keratopathy. Long-term outcome].

Ophthalmologe 1997 Apr;94(4):282-4

Augenklinik Marienhospital, Osnabrück.

View Article
April 1997
10 Reads
0.720 Impact Factor

[Form deprivation myopia caused by keratitis scrophulosa].

Authors:
C Meyer M Müller

Ophthalmologe 1996 Aug;93(4):361-6

Klinik für Augenheilkunde der medizinischen Universität, Lübeck.

View Article
August 1996
9 Reads
0.720 Impact Factor

Corticotropin-releasing hormone receptors on human pituitary cells: autoradiography at the light microscopical level, quantification and immunocytochemistry.

Prog Histochem Cytochem 1992 ;26(1-4):107-9

Department of Experimental Pathology, Vrije Universiteit Brussel, Belgium.

View Article
February 1993
6 Reads
3.640 Impact Factor

Anterior segment anomaly on optical coherence tomography.

Acta Ophthalmol Scand. 2005 Feb;83(1):118-9.

Anterior segment anomaly on optical coherence tomography. Meyer CH, Rodrigues EB, Mennel S. Acta Ophthalmol Scand. 2005 Feb;83(1):118-9.

View Article
1 Read

Chromovitrectomy: a new field in vitreoretinal surgery.

Graefes Arch Clin Exp Ophthalmol. 2005 Apr;243(4):291-3.

Chromovitrectomy: a new field in vitreoretinal surgery. Rodrigues EB, Meyer CH, Kroll P. Graefes Arch Clin Exp Ophthalmol. 2005 Apr;243(4):291-3.

View Article
1 Read

Nutritional supplementation to prevent cataract formation.

Dev Ophthalmol. 2005;38:103-19.

Nutritional supplementation to prevent cataract formation. Meyer CH, Sekundo W. Dev Ophthalmol. 2005;38:103-19. Review. PMID: 15604620

View Article
1 Read

Functional changes after photodynamic therapy with verteporfin.

Am J Ophthalmol. 2005 Jan;139(1):214-5.

Functional changes after photodynamic therapy with verteporfin. Meyer CH, Lapolice DJ, Fekrat S. Am J Ophthalmol. 2005 Jan;139(1):214-5. PMID: 15652863

View Article
3 Reads

Evaluation of granular corneal dystrophy with optical coherent tomography.

Cornea. 2004 Apr;23(3):270-1.

Evaluation of granular corneal dystrophy with optical coherent tomography. Meyer CH, Sekundo W. Cornea. 2004 Apr;23(3):270-1. PMID: 15084860

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1 Read

Visual recovery after scleral buckling surgery in macula-off rhegmatogenous retinal detachment.

Ophthalmologica. 2006;220(3):174-80.

Visual recovery after scleral buckling surgery in macula-off rhegmatogenous retinal detachment. Liu F, Meyer CH, Mennel S, Hoerle S, Kroll P. Ophthalmologica. 2006;220(3):174-80. PMID: 16679792

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1 Read

Patent blue: a novel vital dye in vitreoretinal surgery.

Ophthalmologica. 2006;220(3):190-3.

Patent blue: a novel vital dye in vitreoretinal surgery. Mennel S, Meyer CH, Tietjen A, Rodrigues EB, Schmidt JC. Ophthalmologica. 2006;220(3):190-3. PMID: 16679795

View Article
2 Reads

Subretinal fluid application to close a refractory full thickness macular hole.

Int J Retina Vitreous. 2017 Nov 27;3:44.

Int J Retina Vitreous

Background: To close a refractory full thickness macular hole (FTMH) by adjacent subretinal fluid application to release the elastic retina from the retinal pigment epithelium (RPE). Case presentation: A 83 years old patient presented an old FTMH with a diameter of 1444 μm. After confirming intraoperatively the complete release of the epiretinal membrane around the FTMH, we installed 3 small subretinal blebs around the hole, to release the adjacent retina from the RPE. The mobilized retina was gently moved towards the macular center. A silicone oil tamponade was installed to secure a proper healing and observation of the FTMH. The closure of the 1444 μm FTMH was seen on indirect ophthalmoscopy and confirmed by OCT 5 days after surgery by restoring the retinal architecture. A late reopening was not apparent at the postoperative observations. Visual acuity improved from hand motion to 20/200 at 4 weeks postoperative. Conclusion: Although FTMH develop by epiretinal tangential traction, large FTMH may persist even after complete release of its epiretinal traction. Subretinal fluid application may release the flexible retina from the RPE to achieve a relocation at the central fovea facilitating an anatomical closure of the macular hole. PMID: 29209516 PMCID: PMC5702967 DOI: 10.1186/s40942-017-0094-7 Free PMC Article

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2 Reads

Functional and anatomical findings in acute Purtscher's retinopathy.

Ophthalmologica. 2006;220(5):343-6.

Functional and anatomical findings in acute Purtscher's retinopathy. Meyer CH, Callizo J, Schmidt JC, Mennel S. Ophthalmologica. 2006;220(5):343-6. PMID: 16954714

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1 Read

Ocular photodynamic therapy--standard applications and new indications (part 1). Review of the literature and personal experience

Ophthalmologica. 2007;221(4):216-26.

Ocular photodynamic therapy--standard applications and new indications (part 1). Review of the literature and personal experience. Mennel S, Barbazetto I, Meyer CH, Peter S, Stur M. Ophthalmologica. 2007;221(4):216-26. Review. PMID: 17579286

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1 Read

Ocular photodynamic therapy--standard applications and new indications. Part 2. Review of the literature and personal experience.

Ophthalmologica. 2007;221(5):282-91.

Ocular photodynamic therapy--standard applications and new indications. Part 2. Review of the literature and personal experience. Mennel S, Barbazetto I, Meyer CH, Peter S, Stur M. Ophthalmologica. 2007;221(5):282-91. PMID: 17728549

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1 Read

Mechanisms of intravitreal toxicity of indocyanine green dye: implications for chromovitrectomy.

Retina. 2007 Sep;27(7):958-70

Mechanisms of intravitreal toxicity of indocyanine green dye: implications for chromovitrectomy. Rodrigues EB, Meyer CH, Mennel S, Farah ME. Retina. 2007 Sep;27(7):958-70

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1 Read

Secondary pigmented macular pucker on optical coherence tomography.

Acta Ophthalmol. 2008 Aug;86(5):579-81.

Secondary pigmented macular pucker on optical coherence tomography. Meyer CH, Mennel S, Schmidt JC, Kroll P. Acta Ophthalmol. 2008 Aug;86(5):579-81. Epub 2007 Oct 5. PMID: 17935607

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1 Read

A vitrectomy is done, when the vitreous is gone!

Authors:
Meyer CH.

Dev Ophthalmol. 2008;42:1-4.

A vitrectomy is done, when the vitreous is gone! Meyer CH. Dev Ophthalmol. 2008;42:1-4. doi: 10.1159/000138715. No abstract available. PMID: 18535376

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1 Read

Historical aspects and evolution of the application of vital dyes in vitreoretinal surgery and chromovitrectomy.

Dev Ophthalmol. 2008;42:29-34.

Historical aspects and evolution of the application of vital dyes in vitreoretinal surgery and chromovitrectomy. Rodrigues EB, Penha FM, Furlani B, Meyer CH, Maia M, Farah ME. Dev Ophthalmol. 2008;42:29-34. doi: 10.1159/000138911. PMID: 18535378

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2 Reads

Three simple approaches to visualize the transparent vitreous cortex during vitreoretinal surgery.

Dev Ophthalmol. 2008;42:35-42.

Three simple approaches to visualize the transparent vitreous cortex during vitreoretinal surgery. Schmidt JC, Chofflet J, Hörle S, Mennel S, Meyer CH. Dev Ophthalmol. 2008;42:35-42. doi: 10.1159/000138923. Review. PMID: 18535379

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1 Read

Current concepts of trypan blue in chromovitrectomy.

Dev Ophthalmol. 2008;42:91-100.

Current concepts of trypan blue in chromovitrectomy. Farah ME, Maia M, Furlani B, Bottós J, Meyer CH, Lima V, Penha FM, Costa EF, Rodrigues EB. Dev Ophthalmol. 2008;42:91-100. doi: 10.1159/000138980. Review. PMID: 18535383

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1 Read

Trityl dyes patent blue V and brilliant blue G - clinical relevance and in vitro analysis of the function of the outer blood-retinal barrier.

Dev Ophthalmol. 2008;42:101-14.

Trityl dyes patent blue V and brilliant blue G - clinical relevance and in vitro analysis of the function of the outer blood-retinal barrier. Mennel S, Meyer CH, Schmidt JC, Kaempf S, Thumann G. Dev Ophthalmol. 2008;42:101-14. doi: 10.1159/000138988. PMID: 18535384

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1 Read

Vital dyes in vitreoretinal surgery chromovitrectomy. Preface.

Authors:
Meyer CH.

Dev Ophthalmol. 2008;42:xi-xii.

Vital dyes in vitreoretinal surgery chromovitrectomy. Preface. Meyer CH. Dev Ophthalmol. 2008;42:xi-xii. 18683362

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1 Read

Transconjunctival 20-gauge vitrectomy: a pilot study.

Ophthalmologica. 2009;223(1):12-6.

Transconjunctival 20-gauge vitrectomy: a pilot study. Aguni JS, Meyer CH, Rodrigues EB. Ophthalmologica. 2009;223(1):12-6. doi: 10.1159/000161877. Epub 2008 Oct 13. PMID: 18849631

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1 Read

Acute keratoconus-like hydrops after laser in situ keratomileusis.

J Ophthalmol. 2009;2009:363482.

Acute keratoconus-like hydrops after laser in situ keratomileusis. Meyer CH, Mennel S, Schmidt JC. J Ophthalmol. 2009;2009:363482. doi: 10.1155/2009/363482. Epub 2010 Mar 8. PMID: 20339447

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2 Reads

Combined intravitreal anti-vascular endothelial growth factor (Avastin) and photodynamic therapy to treat retinal juxtapapillary capillary haemangioma.

Acta Ophthalmol. 2010 Aug;88(5):610-3.

Combined intravitreal anti-vascular endothelial growth factor (Avastin) and photodynamic therapy to treat retinal juxtapapillary capillary haemangioma. Mennel S, Meyer CH, Callizo J. Acta Ophthalmol. 2010 Aug;88(5):610-3. doi: 10.1111/j.1755-3768.2008.01449.x. Epub 2009 Feb 12. PMID: 19222401

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1 Read

Radial optic neurotomy for central retinal vein occlusion: long-term retinal perfusion outcome.

Ophthalmologica. 2009;223(5):313-9.

Radial optic neurotomy for central retinal vein occlusion: long-term retinal perfusion outcome. Callizo J, Kroll P, Mennel S, Schmidt JC, Meyer CH. Ophthalmologica. 2009;223(5):313-9. doi: 10.1159/000217730. Epub 2009 May 7. PMID: 19420979

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Time between symptom onset and assessment in age-related macular degeneration with subfoveal choroidal neovascularization.

Ophthalmologica. 2010;224(3):176-82.

Time between symptom onset and assessment in age-related macular degeneration with subfoveal choroidal neovascularization. Schalnus R, Meyer CH, Kuhli-Hattenbach C, Lüchtenberg M. Ophthalmologica. 2010;224(3):176-82. doi: 10.1159/000239236. Epub 2009 Sep 17. PMID: 19776657

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Ability of new vital dyes to stain intraocular membranes and tissues in ocular surgery.

Am J Ophthalmol. 2010 Feb;149(2):265-77.

Ability of new vital dyes to stain intraocular membranes and tissues in ocular surgery. Rodrigues EB, Penha FM, de Paula Fiod Costa E, Maia M, Dib E, Moraes M Jr, Meyer CH, Magalhaes O Jr, Melo GB, Stefano V, Dias AB, Farah ME. Am J Ophthalmol. 2010 Feb;149(2):265-77. doi: 10.1016/j.ajo.2009.08.020. Epub 2009 Nov 6. PMID: 19896637

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Optical coherence tomography-measured pigment epithelial detachment height as a predictor for retinal pigment epithelial tears associated with intravitreal bevacizumab injections.

Retina. 2010 Feb;30(2):203-11

Optical coherence tomography-measured pigment epithelial detachment height as a predictor for retinal pigment epithelial tears associated with intravitreal bevacizumab injections. Chan CK, Abraham P, Meyer CH, Kokame GT, Kaiser PK, Rauser ME, Gross JG, Nuthi AS, Lin SG, Daher NS. Retina. 2010 Feb;30(2):203-11. doi: 10.1097/IAE.0b013e3181babda5. PMID: 19952998

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Tumor necrosis factor-α-mediated severity of idiopathic retinal periphlebitis in young adults (Eales' disease): implication for anti-TNF-α therapy.

J Ocul Biol Dis Infor. 2010 Jul 16;3(1):35-8.

Tumor necrosis factor-α-mediated severity of idiopathic retinal periphlebitis in young adults (Eales' disease): implication for anti-TNF-α therapy. Saxena S, Pant AB, Khanna VK, Singh K, Shukla RK, Meyer CH, Singh VK. J Ocul Biol Dis Infor. 2010 Jul 16;3(1):35-8. doi: 10.1007/s12177-010-9053-3. PMID: 21139707

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Predictive factors for functional improvement after intravitreal bevacizumab therapy for macular edema due to branch retinal vein occlusion.

Graefes Arch Clin Exp Ophthalmol. 2011 Feb;249(2):183-92.

Predictive factors for functional improvement after intravitreal bevacizumab therapy for macular edema due to branch retinal vein occlusion. Jaissle GB, Szurman P, Feltgen N, Spitzer B, Pielen A, Rehak M, Spital G, Heimann H, Meyer CH; Retinal Vein Occlusion Study Group. Graefes Arch Clin Exp Ophthalmol. 2011 Feb;249(2):183-92. doi: 10.1007/s00417-010-1470-2. Epub 2010 Aug 18. PMID: 21337042

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Elevated tumor necrosis factor in serum is associated with increased retinal ischemia in proliferative eales' disease.

Pathobiology. 2011;78(5):261-5.

Elevated tumor necrosis factor in serum is associated with increased retinal ischemia in proliferative eales' disease. Saxena S, Khanna VK, Pant AB, Meyer CH, Singh VK. Pathobiology. 2011;78(5):261-5. doi: 10.1159/000329589. Epub 2011 Aug 17. PMID: 21849807

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Simultaneous confocal scanning laser ophthalmoscopy combined with high-resolution spectral-domain optical coherence tomography: a review.

J Ophthalmol. 2011;2011:743670

Simultaneous confocal scanning laser ophthalmoscopy combined with high-resolution spectral-domain optical coherence tomography: a review. Castro Lima V, Rodrigues EB, Nunes RP, Sallum JF, Farah ME, Meyer CH. J Ophthalmol. 2011;2011:743670. doi: 10.1155/2011/743670. Epub 2011 Nov 1. PMID: 22132313

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Three-dimensional spectral domain optical coherence tomography in Stargardt disease and fundus flavimaculatus.

J Ocul Biol Dis Infor. 2012 Dec 7;5(1):13-8

Three-dimensional spectral domain optical coherence tomography in Stargardt disease and fundus flavimaculatus. Saxena S, Mishra N, Meyer CH. J Ocul Biol Dis Infor. 2012 Dec 7;5(1):13-8. doi: 10.1007/s12177-012-9093-y. eCollection 2012. No abstract available. PMID: 24319520

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Status of serum VEGF and ICAM-1 and its association with external limiting membrane and inner segment-outer segment junction disruption in type 2 diabetes mellitus.

Mol Vis. 2013 Aug 4;19:1760-8.

Status of serum VEGF and ICAM-1 and its association with external limiting membrane and inner segment-outer segment junction disruption in type 2 diabetes mellitus. Jain A, Saxena S, Khanna VK, Shukla RK, Meyer CH. Mol Vis. 2013 Aug 4;19:1760-8. Print 2013. PMID: 23922493

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Progress in chromovitrectomy: 'staining alive'.

Authors:
Meyer CH.

Ophthalmologica. 2013;230 Suppl 2:1-2.

Progress in chromovitrectomy: 'staining alive'. Meyer CH. Ophthalmologica. 2013;230 Suppl 2:1-2. doi: 10.1159/000354053. Epub 2013 Sep 6. No abstract available. PMID: 24022712

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Effect of novel vital dyes on outer blood-retina barrier function in cultured human retinal pigment epithelium.

Ophthalmologica. 2013;230 Suppl 2:33-40. doi: 10.1159/000353869.

Effect of novel vital dyes on outer blood-retina barrier function in cultured human retinal pigment epithelium. Liu Z, Meyer CH, Stanzel BV; International Chromovitrectomy Collaboration. Ophthalmologica. 2013;230 Suppl 2:33-40. doi: 10.1159/000353869. Epub 2013 Sep 6. PMID: 24022717

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Biochemical analysis and decomposition products of indocyanine green in relation to solvents, dye concentrations and laser exposure.

Ophthalmologica. 2013;230 Suppl 2:59-67

Biochemical analysis and decomposition products of indocyanine green in relation to solvents, dye concentrations and laser exposure. Penha FM, Rodrigues EB, Maia M, Meyer CH, Costa Ede P, Dib E, Bechara E, Lourenço A, Lima Filho AA, Freymüller EH, Farah ME; International Chromovitrectomy Collaboration. Ophthalmologica. 2013;230 Suppl 2:59-67 doi: 10.1159/000353871. Epub 2013 Sep 6. PMID: 24022720

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A trichrome RGB endoillumination prototype system: a novel application for chromovitrectomy.

Ophthalmologica. 2013;230 Suppl 2:73-6.

INTRODUCTION: LED cold light sources are utilized nowadays for endoillumination in vitreoretinal surgery. We investigated the effects of an individual mixing of red, green and blue (RGB) light from an LED illumination prototype for chromovitrectomy. METHODS AND TECHNIQUE: A novel RGB LED cold light illumination system (Dieter Mann GmbH, Mainaschaff, Germany) contains 3 RGB light sources, allowing for an individual mixing of light, so that the surgeon can adjust and control the color quality and intensity of the applied light during chromovitrectomy. RESULTS: Adding or subtracting the amount of any RGB light will consecutively change the resulting color of the light in the eye. The visualization of the retina or semitransparent naïve structures like the vitreous depends on the illumination. The visualization of epiretinal membranes stained with vital dyes can be enhanced by an individual adjustment of the applied light. CONCLUSION: Selective subtraction of one RGB light unit may increase the visibility of delicate structures during pars plana vitrectomy. © 2013 S. Karger AG, Basel. PMID: 24022722 DOI: 10.1159/000354168

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Peripapillary astrocytic hamartomas evolve from the optic nerve.

BMJ Case Rep. 2015 Jan 23;2015.

Astrocytic hamartomas are rare benign tumours. Spectral domain optical coherence tomography (SD-OCT) with advanced visualisation (optic disc cube 200×200) was performed on a 27-year-old man with peripapillary astrocytic hamartomas in the right eye. En face (OCT scan) view (CT scan) of the optic nerve at the level of retinal pigment epithelium revealed optic nerve fibres along with three associated areas showing optical shadowing corresponding with astrocytic hamartomas in continuum. An area of optical shadowing was also observed superiorly in the retinal tissue corresponding with another astrocytic hamartoma. Astrocytes in diffusely vascularised rat retina have been reported to be immigrants from the optic nerve. En face SD-OCT-based in vivo histology for the first time provides strong evidence that peripapillary astrocytic hamartomas are derived from optic nerve astrocytes. PMID: 25618878 PMCID: PMC4307038 DOI: 10.1136/bcr-2014-207275

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IInfluence of ocular volume and lens status on pharmacokinetics and duration of action of intravitreal vascular endothelial growth factor inhibitors.

Retina. 2015 Jan;35(1):69-74.

PURPOSE: To assess the effects of ocular axial length, refraction, and lens status on pharmacokinetics and duration of action of the vascular endothelial growth factor (VEGF) inhibitors ranibizumab and bevacizumab after intravitreal injection in humans. METHODS: In 119 eyes of 119 patients, aqueous humor was sampled at different time points after intravitreal injection of ranibizumab or bevacizumab, and either drug or VEGF concentrations were measured by enzyme-linked immunosorbent assays and Luminex multiplex bead technology, respectively. Relative deviation of the measured drug concentrations from the time-corrected mean values was calculated (n = 41). Repetitive VEGF measurements were preformed to identify the duration of complete suppression of ocular VEGF activity for individual eyes (n = 78). In addition, axial length, spherical equivalent refraction, and lens status were determined. RESULTS: For neither ranibizumab nor bevacizumab, a correlation between ocular pharmacokinetics (as measured by relative deviation of drug concentration from the mean) and axial length was detected in phakic eyes (Spearman's correlation coefficient, r = 0.084; P = 0.600). Similarly, the duration of action of intravitreal ranibizumab (as measured by VEGF suppression time) did not correlate with spherical equivalent refraction in phakic eyes (Spearman's correlation coefficient, r = 0.164; P = 0.301) and was not different between phakic and pseudophakic eyes (P = 0.694; Mann-Whitney U test). CONCLUSION: The results indicate that ocular volume and lens status have no relevant impact on ocular pharmacokinetics and duration of action of VEGF-inhibitory drugs and may, thus, be excluded as factors accounting for the high interindividual variability in morphologic and functional responses to intravitreal anti-VEGF therapy. PMID: 25077535 DOI: 10.1097/IAE.0000000000000265

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Routes for Drug Delivery to the Eye and Retina: Intravitreal Injections.

Dev Ophthalmol. 2016;55:63-70.

The advantage of intravitreal injections is an immediate and increased therapeutic effect in the intended retinal tissue. The accuracy, precision and reproducibility of the delivered volume depend on the size of the syringe and the physician's manual experience. The eyelids and eyelashes are usually disinfected using a povidone-iodine solution (10%); a sterile speculum is placed and drops of povidone-iodine (5%) are applied. The use of adequate anesthetic topical lidocaine 2% is required. The injection site should be located 3.5-4 mm posterior to the limbus. The angle of the incision through the sclera may be directed in an oblique fashion of 30°. The diameter of the needle should be smaller than 25 G, and the injected volume should be limited to 0.15 ml without a routine paracentesis. The incidence of lens injury is 0.006% (2/32,318) and 0.013% (5/35,942) for rhegmatogenous retinal detachments. The rate of suspected endophthalmitis is 0.018% after bevacizumab and 0.027% after ranibizumab injections. Sterile inflammations have been observed after Avastin injections. The concentrations of vascular endothelial growth factor inhibitors decline in a monoexponential fashion. The half-life of unbound bevacizumab is 9.82 days and that of ranibizumab 7.19 days. PMID: 26501462 DOI: 10.1159/000431143

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Injection scheme for intravitreal bevacizumab therapy for macular oedema due to central retinal vein occlusion: results of a multicentre study.

Acta Ophthalmol. 2017 May;95(3):e245-e246.

Injection scheme for intravitreal bevacizumab therapy for macular oedema due to central retinal vein occlusion: results of a multicentre study. Szurman GB, Januschowski K, Szurman P, Feltgen N, Spitzer B, Pielen A, Rehak M, Spital G, Dimopoulos S; Bevacizumab Study Group Venous Occlusion, Meyer CH. Acta Ophthalmol. 2017 May;95(3):e245-e246. PMID: 26833721 DOI: 10.1111/aos.12976

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Investigation of new dyes for chromovitrectomy: preclinical biocompatibility of trisodium, orangell and methyl violet.

Int J Retina Vitreous. 2015 Apr 15;1:1.

PURPOSE: To investigate the retinal toxicity by electroretinography (ERG), clinical examination and histology after intravitreal injection of biological stains in two concentrations: Trisodium (0.50 g/L and 1.00 g/L), Orangell (0.25 g/L and 1.00 g/L) and Methyl Violet (0.50 g/L and 1.00 g/L). METHODS: Eighteen New-Zealand albinos rabbits were assigned in six groups (n = 3 in each group). The animals in group 1 received Trisodium in the dose of 0.50 g/L and group 2 received 1.00 g/L; Group 3 received Orangell in the dose of 0.25 g/L and group 4 received 1.00 g/L; Group 5 received Methyl Violet in the dose of 1.00 g/L and group 6 received 0.50 g/L. A volume of 0.05 mL of dye was injected in the right eyes, whereas the left eyes received the same volume of balanced salt solution (BSS) as control. ERG recordings and clinical examination were performed at baseline and seven days after intravitreal injection. The ERG responses at one week after injection were compared with baseline levels. A decrease in the post-injection amplitude of more than 50% was considered remarkable. After the 7-day follow-up, rabbits were euthanized and eye enucleated for light microscopy (LM) histological evaluation. RESULTS: At clinical examination by indirect ophthalmoscopy seven days after dye injection, all eyes were negative for cataract, hemorrhage, retinal detachment, and intraocular opacities. Amplitude analysis of maximum scotopic b-wave showed no significant reduction in either dye injected or control eyes. Neither dye nor BSS caused significant retinal alteration on LM at doses tested. CONCLUSIONS: Trisodium, Orangell and Methyl Violet can be applied in future studies in order to prove the capacity to stain preretinal tissues and vitreous without toxicity. The three dyes did not induce significant ERG amplitude reduction or LM alterations in this preliminary experimental research. Trisodium, Orangell and Methyl Violet may be potentially useful vital dyes for ocular surgery, and deserve further investigation. KEYWORDS: Chromovitrectomy; ERG; Eletroretinography; Methyl violet; Orangell; Retina; Toxicity; Trisodium; Vitretomy.

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Biocompatibility of the vital dye Acid Violet-17 on retinal pigment epithelial cells.

Clin Ophthalmol. 2016 Jul 29;10:1435-45

PURPOSE: To examine the viability and differentiation of retinal pigment epithelial (RPE) cells after exposure to the vital dye Acid Violet-17 (AV-17). METHODS: Bovine RPE cells were incubated with AV-17 (0.0625-0.5 mg/mL) for 30 seconds or 5 minutes. Viability was determined by live/dead staining, cleaved CASP3 immunostainings, and MTT test. Actin cytoskeleton was visualized by Alexa 488-phalloidin. Immunocytochemistry was performed to determine the levels of ZO-1, CTNNB1, and KRT19. RESULTS: Exposure to AV-17 at the concentrations of 0.25-0.5 mg/mL resulted in a dose-dependent decrease in viability, the loss of ZO-1 from tight junctions, translocation of CTNNB1 into the cytoplasm and nucleus, disarrangement of the actin cytoskeleton, and a slight increase in KRT19. CONCLUSION: AV-17 at a concentration <0.125 mg/mL is likely to be well tolerated by the RPE cells, whereas the concentrations from 0.25 mg/mL onward can reduce viability and induce dedifferentiation particularly after long-term exposure. KEYWORDS: Acid Violet-17; biocompatibility; differentiation; retinal pigment epithelial cells; viability

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Superior Rim Stability of the Lens Capsule Following Manual Over Femtosecond Laser Capsulotomy.

Invest Ophthalmol Vis Sci. 2016 May 1;57(6):2839-49.

PURPOSE: Cataract surgery requires the removal of a circular segment of the anterior lens capsule (LC) by manual or femtosecond laser (FL) capsulotomy. Tears in the remaining anterior LC may compromise surgical outcome. We investigated whether biophysical differences in the rim properties of the LC remaining in the patient after manual or FL capsulotomy (FLC) lead to different risks with regard to anterior tear formation. METHODS: Lens capsule samples obtained by either continuous curvilinear capsulorhexis (CCC) or FLC were investigated by light microscopy, laser scanning confocal microscopy, and scanning electron microscopy; atomic force microscopy (AFM) was used to test the biomechanical properties of the LC. The mechanical stability of the LC following either of the two capsulotomy techniques was simulated by using finite-element modeling. RESULTS: Continuous curvilinear capsulorhexis produced wedge-shaped, uniform rims, while FLC resulted in nearly perpendicular, frayed rims with numerous notches. The LC is composed of two sublayers: a stiff epithelial layer that is abundant with laminin and a softer anterior chamber layer that is predominantly made from collagen IV. Computer models show that stress is uniformly distributed over the entire rim after CCC, while focal high stress concentrations are observed in the frayed profiles of LC after FLC, making the latter procedure more prone to anterior tear formation. CONCLUSIONS: Finite-element modeling based on three-dimensional AFM maps indica

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INTRAVITREAL INJECTIONS OF ZIV-AFLIBERCEPT FOR DIABETIC MACULAR EDEMA: A Pilot Study.

Retina. 2016 Sep;36(9):1640-5.

PURPOSE: Diabetic macular edema is the leading cause of blindness in young adults in developed countries. Beyond metabolic control, several therapies have been studied such as laser treatment and intravitreal injections of corticosteroids or anti-vascular endothelial growth factor drugs. In terms of public health the long-term treatment with the current available drugs is very expensive and new therapies with the same or better effect should be investigated. This study sought to evaluate the efficacy and safety of intravitreal injections of ziv-aflibercept for the treatment of diabetic macular edema. METHODS: Seven consecutive patients with diabetic macular edema were enrolled. A complete examination, including full-field electroretinography, visual acuity, central retinal thickness, and evaluation of systemic and ocular complications, was performed before and at 24 weeks after intravitreal injections of ziv-aflibercept. The seven patients were submitted to six consecutive intravitreal injections of ziv-aflibercept with a 4-week interval. RESULTS: No significant differences were found in the amplitude or implicit time of any electroretinography component after intravitreal injections of ziv-aflibercept, and no systemic or ocular complication was observed. The improvement of visual acuity was significant at 24 weeks (P < 0.05). The central retinal thickness significantly decreased during the course of 24 weeks. CONCLUSION: Intravitreal injections of ziv-aflibercept seem to be a safe and effective treatment option for diabetic macular edema.

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The potential of spectral domain optical coherence tomography imaging based retinal biomarkers.

Int J Retina Vitreous. 2017 Jan 9;3:1.

Int J Retina Vitreous.

BACKGROUND: Biomarker", a merged word of "biological marker", refers to a broad subcategory of medical signs that objectively indicate the state of health, and well-being of an individual. Biomarkers hold great promise for personalized medicine as information gained from diagnostic or progression markers can be used to tailor treatment to the individual for highly effective intervention in the disease process. Optical coherence tomography (OCT) has proved useful in identifying various biomarkers in ocular and systemic diseases. MAIN BODY: Spectral domain optical coherence tomography imaging-based biomarkers provide a valuable tool for detecting the earlier stages of the disease, tracking progression, and monitoring treatment response. The aim of this review article is to analyze various OCT based imaging biomarkers and their potential to be considered as surrogate endpoints for diabetic retinopathy, age related macular degeneration, retinitis pigmentosa and vitreomacular interface disorder. These OCT based surrogate markers have been classified as retinal structural alterations (macular central subfield thickness and cube average thickness); retinal ultrastructural alterations (disruption of external limiting membrane and ellipsoid zone, thinning of retinal nerve fiber layer and ganglion cell layer); intraretinal microangiopathic changes; choroidal surrogate endpoints; and vitreoretinal interface endpoints. CONCLUSION: OCT technology is changing very quickly and throughout this review there are some of the multiple possibilities that OCT based imaging biomarkers will be more useful in the near future for diagnosis, prognosticating disease progression and as endpoint in clinical trials.

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Resistive index of ophthalmic artery correlates with retinal pigment epithelial alterations on spectral domain optical coherence tomography in diabetic retinopathy

Int J Retina Vitreous. 2018 Apr 9;4:12.

Int J Retina Vitreous

Background: Retinal pigment epithelium (RPE) plays a significant role in maintenance of integrity of retinal photoreceptors and choriocapillaries. RPE derives its blood supply through ophthalmic artery (OA) via choriocapillaries. RPE topographic alterations have been observed to be associated with severity of retinopathy. The present study was undertaken to assess the correlation between resistive index (RI) of the OA with RPE topographic alterations on Spectral-Domain optical coherence tomography (SD-OCT), to our knowledge, it is for the first time. Methods: A tertiary care center based cross-sectional study was undertaken after informed consent. Sample size was calculated using 95% confidence interval. Seventy five consecutive cases of type 2 diabetes mellitus between the ages of 40 and 70 years were included. The cases were divided into three groups according to Early Treatment Diabetic Retinopathy Study classification: diabetes mellitus with no retinopathy (No DR) (n = 24); non-proliferative diabetic retinopathy (n = 27); and proliferative diabetic retinopathy (n = 24). Healthy control subjects of similar age group were included (n = 24). RI in OA was studied using Color Doppler imaging. Grades of RPE topographic alterations and retinal photoreceptor ellipsoid zone (EZ) disruption were studied using SD-OCT. Data was analysed using Chi square (χ2) test, analysis of variance (ANOVA), Pearson correlation analysis and Neuman-Keuls test. Results: LogMAR best corrected visual acuity was found to increase significantly with the severity of DR (F = 105.74, p < 0.001). ANOVA revealed a sBackground: Retinal pigment epithelium (RPE) plays a significant role in maintenance of integrity of retinal photoreceptors and choriocapillaries. RPE derives its blood supply through ophthalmic artery (OA) via choriocapillaries. RPE topographic alterations have been observed to be associated with severity of retinopathy. The present study was undertaken to assess the correlation between resistive index (RI) of the OA with RPE topographic alterations on Spectral-Domain optical coherence tomography (SD-OCT), to our knowledge, it is for the first time. Methods: A tertiary care center based cross-sectional study was undertaken after informed consent. Sample size was calculated using 95% confidence interval. Seventy five consecutive cases of type 2 diabetes mellitus between the ages of 40 and 70 years were included. The cases were divided into three groups according to Early Treatment Diabetic Retinopathy Study classification: diabetes mellitus with no retinopathy (No DR) (n = 24); non-proliferative diabetic retinopathy (n = 27); and proliferative diabetic retinopathy (n = 24). Healthy control subjects of similar age group were included (n = 24). RI in OA was studied using Color Doppler imaging. Grades of RPE topographic alterations and retinal photoreceptor ellipsoid zone (EZ) disruption were studied using SD-OCT. Data was analysed using Chi square (χ2) test, analysis of variance (ANOVA), Pearson correlation analysis and Neuman-Keuls test. Results: LogMAR best corrected visual acuity was found to increase significantly with the severity of DR (F = 105.74, p < 0.001). ANOVA revealed a significant increase in RI of OA (F = 14.23, p < 0.001) with severity of diabetic retinopathy. χ2 test revealed significant increase in grades of RPE alterations (χ2 = 71.83, p < 0.001) and EZ disruption (χ2 = 60.59, p < 0.001) with the severity of diabetic retinopathy. Pearson correlation analyses revealed a significant positive correlation between RI of OA with grades of RPE alterations (r = 0.48, p < 0.001) and also between grades of RPE alterations and EZ disruption (r = 0.82, p < 0.001). Conclusions: Decrease in ocular blood flow resulting from an increase in RI of OA correlates with severity of DR and grades of topographic alterations in RPE. Integrity of EZ was observed to be dependent on RPE.ignificant increase in RI of OA (F = 14.23, p < 0.001) with severity of diabetic retinopathy. χ2 test revealed significant increase in grades of RPE alterations (χ2 = 71.83, p < 0.001) and EZ disruption (χ2 = 60.59, p < 0.001) with the severity of diabetic retinopathy. Pearson correlation analyses revealed a significant positive correlation between RI of OA with grades of RPE alterations (r = 0.48, p < 0.001) and also between grades of RPE alterations and EZ disruption (r = 0.82, p < 0.001). Conclusions: Decrease in ocular blood flow resulting from an increase in RI of OA correlates with severity of DR and grades of topographic alterations in RPE. Integrity of EZ was observed to be dependent on RPE.

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Top co-authors

Sandeep Saxena
Sandeep Saxena

King George's Medical University

23
Eduardo B Rodrigues
Eduardo B Rodrigues

Vision Institute IPEPO

18
Michel Eid Farah
Michel Eid Farah

Federal University of São Paulo

12
Frank G Holz
Frank G Holz

University of Bonn

10
Michel E Farah
Michel E Farah

Federal University of São Paulo

9
Nibha Mishra
Nibha Mishra

Birla Institute of Technology

7
Nicolas Feltgen
Nicolas Feltgen

University of Freiburg

7
Zengping Liu
Zengping Liu

University of Bonn

7
Fernando M Penha
Fernando M Penha

Federal University of São Paulo

6